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"tangles" Synonyms
problems holes jams cruxes knots mires pitfalls quagmires spots toughies misadventures mishaps straits deep water matters muddles cases corners facers fixes mass mats mazes snarls webs meshes messes clusters coils jumbles jungle entanglement thatch twists labyrinths rummages scrambles skeins snags confusion disorder disorderedness havoc chaos disarrangement disarrays disorderliness disorganisations(UK) disorganization(US) madhouses shambles bedlams botches dishevelment hashes imbroglios bewilderments bafflement befuddlement bemusements puzzlement perplexity mystification bamboozlement bewilderedness discombobulations confusedness distraction fog whirls head-scratchings dazes stupors snares traps nets nooses catch morasses quicksand tanglement dangers hazard peril entrapment embranglement involvement ensnarement scraps fights brawls fracases clashes scuffles tussles frays melees affrays skirmishes battles scrimmages ruckuses broils rumpuses riots ructions shindies wrangles assortments mishmashes medleys miscellanies hodgepodge variety patchwork potpourris hotchpotches collages pastiches farragos montages ragbags clutter motleys agglomerations tiffs argument disputes quarrels disagreements squabbles rows altercation spats contretemps misunderstandings donnybrooks controversies bickers hassles kink crimps curls loops twirls frizz ringlets warps wrinkles corkscrews crinkles distortion irregularities gnarls contortions predicaments difficulty dilemmas jam quandaries pickles scrapes binds mix-ups trouble impasses huddles groups bunches batches collections arrays sets lots groupings blocks assemblage clutches bands constellations suites clumps batteries banks parcels ties links bonds joints hitches interlacement intertwinements joins splices connection splicings bows ligature seaweed gulfweed rockweeds sea girdles seaware shocks head manes mops bush cascades clouds crops foam fuzz halos quiffs backlashes counteractions retaliation responses comebacks recoils resistance reactions repercussions backfires counterattacks fallout reprisal backwash retroactions resentment boomerangs counterblasts criticism kickback thickets copses coppices coverts brakes brushwood boscage woodland undergrowth wood chaparrals brushes groves shrubberies boskages underbrush bosks spinneys hursts bosques hindrances impediments obstacles issues hiccups complication obstructions drawbacks barriers setbacks checks glitches entangles intertwists enmeshes intertwines interweaves ravels entwines interlaces immeshes interlocks kinks catches ensnares entraps ensnarls entoils catches up hooks captures bags lands grabs embroils implicates involves associates concerns exposes incriminates affects connects mixes up ties up drags into makes a party to inculpates stitches up draws argues contends faces confronts opposes messes with comes into conflict crosses swords has a dispute locks horns becomes involved comes up against squares up disturbs discomposes perturbs worries afflicts bothers confounds confuses deranges discomfits disconcerts distracts distresses flusters irks troubles unsettles upsets vexes agitates disorders disarranges disorganizes disrupts dishevels musses tousles shuffles rumples dislocates disjoints intermixes blends combines mixes merges fuses amalgamates integrates mingles melds incorporates commingles intermingles homogenises(UK) homogenizes(US) interfuses unites commixes coalesces compounds perplexes puzzles baffles bewilders mystifies befuddles flummoxes bemuses dumbfounds nonplusses stumps addles bamboozles discombobulates foxes fuddles gets sticks wedges clings becomes lodged becomes stuck becomes trapped becomes wedged becomes fixed competes vies wrestles challenges rivals encounters jousts spars wages war clashes with competes against complicates embarrasses complexes complexifies sophisticates makes difficult snarls up bedevils clogs convolutes copes manages survives deals endures grapples hacks handles fares lives subsists weathers struggles suffers dispatches disagrees differs altercates falls out argufies brabbles controverts More

423 Sentences With "tangles"

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It also has a safety feature that protects against tangles.
If the yarn tangles easily, it means she's feeling troubled.
The parachute deployed successfully, and without major rips or tangles.
Tangles of colorful ethernet cords spewed from stacks of servers.
The 49ers' hiring of Chip Kelly tangles the web further.
Tangles of them lie in huge meshes on the floor.
He also studied tangles of proteins associated with Alzheimer's disease.
They allow plaques and tangles to accrete in the brain.
These detailed images allow scientists to parse apart the molecular structure of the tangles, which could help them understand why the tangles happen, how they spread, and possibly even develop drugs to treat them.
At the edge, tangles of roots reach down into the shallows.
Trump's own tangles with corruption are pretty familiar at this point.
It's also possible that these tangles of DNA aren't significant at all.
Tangles of power lines weigh down the utility poles they're strung from.
A small amount transforms knots and tangles into smooth-as-silk hair.
While her text drifts and tangles, the woman as narrator remains steadfast.
In someone with full-blown Alzheimer's, abnormal clumps of both proteins, called plaques and tangles, respectively, form and litter the brain (plaques are mostly found in the space between nerve cells, while tangles mostly form inside nerve cells).
A drug recently trialled to bust these tangles was LMTM, by TauRx pharmaceuticals.
Their medium-length coat requires weekly brushing to keep it free of tangles.
The Frenchman will have to make sure there are no tangles with Ricciardo.
Tangles of old film and manila rope haunt the area beneath he stage.
She tangles with Sophia, who gets her opinions from the right-wing tabloids.
Vic tangles with Manx, who seems to be feeding on the children he steals.
By stopping things like knots, frizz, dents, tangles, and flat hair before they start.
Amyloid forms plaques outside of brain cells, while tau forms tangles within the cells.
Prevent tangles by brushing your hair before you get it wet in the shower.
These deposits of amyloid plaque and tau tangles are considered "biomarkers" of Alzheimer's disease.
It connects via USB with a quality fabric cord too, which prevents some tangles.
Closer up you see that they're marked with faint, wavelike tangles of colored lines.
So far this process has merely replaced the algae with tangles of water plants.
An illustration of plaques, seen in brown, and tangles, seen in blue, in the brain.
These tangles are associated with the decline in mental abilities caused by diseases like Alzheimer's.
Ever the hair obsessive, Villanelle strokes Eve's face and tangles her hand in her hair.
By the time these mice reached six months old, the tangles were almost entirely absent.
Bombardments turned familiar childhood streets into lopsided hills of rubble and spaghetti tangles of rebar.
Cummings was last seen leaving her job at Tangles in Fernandina Beach at 5 p.m.
The Senate debate this week on the Sasse bill highlighted some glaring tangles of logic.
For all the tangles of its plot, things fall apart rather quickly on The Affair.
Their ugly tangles with politicians, police, and mobsters are a crucial part of Hollywood history.
Granted, some poems are thorny, difficult tangles requiring significant work from the reader to comprehend.
Patients with the mutation appeared to develop only plaques and tangles, and no other pathologies.
Throughout the 2019 debates, Ms. Warren avoided directly confronting Mr. Biden about their past tangles.
Its circular design keeps your cables and devices away from each other, so nothing tangles.
There's pad thai, too, tangles of wok-charred noodles laced with tamarind and palm sugar.
In place of trees, strange tuxedoed servants have tangles of branches sprouting from their necks.
These plaques subsequently set another process in motion, whereby tau forms tangles that destabilize brain cells.
Together, the neuronal disruptions caused by these plaques and tangles result in the onset of dementia.
Slow down: It still isn't clear if tau tangles, amyloid plaques or something else cause Alzheimer's.
She will take 4,000 baht ($110) for it, she says, while brushing tangles from its hair.
They often get in tangles with the law, having to bribe their way out of jail.
Packed into a dense knot of prose-formatted lines, the poem tangles seemingly unrelated, fragmented thoughts.
The courtyard garden is profuse and untamed, with tangles of ivy and roses, foxgloves and lupines.
But their tangles are an extension of the fight Sanders and Clinton were having in 20183.
Cerebrospinal fluid analysis revealed tell-tale amyloid plaques and neurofibrillary tangles, the fingerprints of Alzheimer's disease.
Some vignettes are anecdotal; others are tangles of passive aggression, racial hostility or repellent one-upmanship.
Pruitt declined to comment on the earthquakes or his tangles with the EPA before his confirmation hearing.
The twisted tangles are thought to block the transport of nutrients in cells, causing them to die.
When starting with dry hair, remove any tangles with the Cricket Co. Copper Clean Paddle Brush. 2.
The community was littered with fallen trees, strewn debris and tangles of downed wires and utility poles.
The tangles of tau can overtake parts of the brain that control for memory, mood and aggression.
The way the candidate tangles up the truth, confounding and soft-soaping his interviewers, requires constant vigilance.
When it becomes abnormal, it aggregates into tangles that kill neurons and can spread through the brain.
Though it was late in the season, there were still tangles of bull kelp in the water.
All night I pluck endless burrs from the tangles as though I were plucking souls from Purgatory.
Mr. Bavouzet tore through the piece with abandon, dispatching tangles of lines and chords with flinty power.
On autopsy, he found peculiar plaques and twisted, spaghetti-like proteins known as tangles in her brain.
Her attempt to disentangle good American patriotism from bad American nationalism, however, tangles American history in knots.
Inner details came through vividly, especially intricate tangles of counterpoint during teeming episodes of the first movement.
Years of tangles with competition regulators in Europe followed, along with a string of private antitrust lawsuits.
Sooner or later, Glenn got into tangles with all of them, especially with Peter, and was replaced.
Amyloid betas are the trigger, and twisted protein fibers, called tangles, are the actual bullets that kill.
Butler looks to continue its impressive nonconference home winning streak when it tangles with Youngstown State on Saturday.
You've fed them the best deep conditioners, removed all knots and tangles, and scrunched them to the gods.
Kessler worked with Cummings at Tangles Hair Salon and was allegedly the last person to see her alive.
"When the tongue glides over fur, the hooks are able to lock onto tangles and snags," Noel explained.
Another person responded to explain that "no tears" meant no tears in your hair, as in, no tangles.
Don't be discouraged — successful detangling is simply a matter of finding the right product for your unique tangles.
It's easy to imagine perfect curls — big, healthy ringlets and coils with zero tangles and plenty of bounce.
Razer's earbuds include an in-line remote and mic along a flat cable that should help reduce tangles.
A close-up illustration of abnormal tau tangles, in blue, which play a debated role in Alzheimer's disease.
Plaques and tangles, in this theory, are essentially just the "dead," inactive remains of amyloid and tau prions.
It twists and turns into beautiful, doughy tangles, stenciled with flour to create striking pictures on its crust.
Keep in mind this recipe includes a dollop of homemade almond ricotta cheese and tangles of coconut bacon.
Oklahoma tangles with Oregon State while the Gophers continue their ambitious non-conference schedule by playing at Butler.
Color starts fading, strands feel dry and brittle, and don't even get us started on salt-water tangles.
But Mr. Pollini sensitively drew out the plaintive melodic lines that penetrate the tangles of passagework and counterpoint.
But we also came across numerous bolted pieces of metal with anti-corrosion paint and tangles of cabling.
The researchers found plaques of a protein called beta amyloid, along with the tangles of another protein called tau.
Pylons and tangles of bramble high as houses tower over a lonely oil drum and a collapsed metal fence.
There, Ms. Watts is kidnapped by King Kong and tangles with dinosaurs as the crew tries to rescue her.
She has millions of followers on Twitter, where she frequently promotes her liberal policy positions and tangles with critics.
The telltale sign of the disease is tangles of the protein tau, which takes over parts of the brain.
And don't worry about tangles with nylon pins and tufted bristles that gently grab and smooth out your hair.
Should Mr. Trump lose tonight, his tangles with Wisconsin's conservative talk radio hosts may be seen as a factor.
The series tells the story of John Constantine, a chain-smoking, wisecracking magician who frequently tangles with the Devil.
His textured aesthetic makes the contours of his figures look like intertwined tendrils of hair or tangles of fur.
"Drugs to hit amyloid early on, drugs to hit tangles early on, drugs to hit inflammation," Dr. Tanzi said.
L's provocative performances in particular mix issues of art, the body, language and race into thorny, mind-bending tangles.
To confound matters, even the assumption that plaques and tangles cause the symptoms of Alzheimer's is now being questioned.
I also spied the tau tangles that look like hair clogging a drain and are characteristic of Alzheimer's pathology.
"Tau is the right target ... (but) that's a terrible drug," he said, questioning the approach of bursting the tangles apart.
The logic of landscape painting (a slight misnomer considering the tangles of painterly interpretation) is where Hatton's efforts are concentrated.
Kessler, a co-worker at Tangles Hair Salon with Cummings, is charged with grand theft auto, First Coast News reports.
But sometimes, those proteins become tangled, and the tangles can build up and warp the neuron's shape, rendering them useless.
Now you say you're not a political person, but you've gotten in some tangles with the Trumps still this year.
Amyloid plaques and Tau tangles—the pathological hallmarks of the disease—can be observed 20 years before actual symptoms appear.
The sprawling tangles of brown seaweed, above, provide a vital habitat and food source for a wide range of species.
Mr. Passantino is a lawyer who has represented former House Speakers Dennis Hastert and Newt Gingrich in their ethical tangles.
They analyzed their spinal fluid for the presence of indicators of the plaques and tangles that are characteristic of Alzheimer's.
Credico is also central to one of the more significant tangles between prosecutors and the defense team before the trial.
The Democratic nominee who tangles with Trump next fall shouldn't waste his or her time reaching out for Republican votes.
Mr. Trifonov dispatched the score's tangles of passagework and breathless flights in a performance that balanced fearless command and wildness.
Jake's father (Greg Kinnear) tangles with Leonor (Paulina Garcia), the seamstress who has rented the first-floor shop for years.
Mr Berlusconi's rise to power disrupted Italian politics, with his various legal tangles and a campaign that was vulgar in tone.
The presence of these plaques sets another process in motion, whereby another protein, called tau, forms tangles that destabilize brain cells.
Why it matters: Tau tangles have been implicated in a number of neuro-degenerative diseases, including Alzheimer's, Huntington's and Parkinson's Disease.
Then, as tangles of tau kill nerve cells, the brain becomes inflamed, resulting in the killing of many more nerve cells.
Surrounded by embossed walls, columns, and arches, squads of testosterone-fueled dudes wearing coifed wigs plunge into orgiastic tangles of women.
One of Midge's most striking riffs tangles with a different taboo: maybe, she suggests, she wasn't meant to be a mother.
Despite his many tangles with the law, Mr. Brown's career has repeatedly bounced back, mostly because of his ardent fan base.
When these abnormal tau proteins clump they form "tangles" -- a key sign of Alzheimer's, frontal lobe dementia and Lewy body disease.
Foreign leaders often find themselves standing uncomfortably while their host tangles with reporters about health care policy or other domestic issues.
Zheng Xianqiao, the father of the student who committed suicide, is still reeling from his son's tangles with the loan companies.
Xchange may be key to Uber's continued expansion as it tangles with Lyft in the U.S. and a bevy of competitors abroad.
Another suspect thought to play a key role is a protein known as tau, which forms tangles inside cells in the brain.
By noon Saturday, the group of alt-right white nationalists grew to include tangles of neo-Nazis and the Ku Klux Klan.
Institutional Shareholder Services (ISS), an influential proxy-advisory firm, recently noted that the board had presided over bureaucratic tangles and botched acquisitions.
She suffers from an arteriovenous malformation, or AVM, abnormal tangles of blood vessels that disrupt the connection between the arteries and veins.
And we already know there are other neurological disorders, such as frontotemporal dementia, that are almost certainly driven by tau tangles alone.
The problem with a brain that is constantly inventing scenarios, vignettes, and characters is that the imagined tangles constantly with the real.
The condition is believed to be caused by a buildup of beta amyloid plaques and neurofibrillary tangles called tau in the brain.
Now she deflects questions about the emails and foundation ethical tangles by summoning up the specter of the Vast Alt-Right Conspiracy.
The rest of the menu is rounded out by gentle curries and tangles of stir-fried noodles, crowd-pleasing if not revelatory.
In the foreground, in a place of honor, sit several glass-bejeweled metal tangles by Claire Falkenstein, who died in Venice, Calif.
The disease is thought to be caused by a buildup in the brain of beta amyloid plaques and neurofibrillary tangles called tau.
In the pair's collaborative canvases, their signatures form large, semi-legible tangles — variously fragmented, magnified and reversed, in snappy black on white.
Amyloid's a match, the tangles are a brush fire being spread as they kill neurons, and the virus is lighting the match.
I have thick type-3A curls and deal with tangles every single wash, so the detangling spray stood out to me immediately.
That, and the way it tangles with the equally fluent playing of Julian Lage, a wunderkind guitarist one generation Mr. Cline's junior.
The disease is thought to be caused by a buildup in the brain of beta amyloid plaques and protein tangles called tau.
Most of the visual tricks she employs get blurred, as when she uses masking tape to produce seemingly impossible tangles of lines.
A week later, the court told America that procedural tangles prevented it from doing anything to curb partisan gerrymandering—at least for now.
They feed tangles of materials into the printers and scoop parts from the robotic haulers that wheel along pathways between the big machines.
It's incredibly lightweight, smells like a Hawaiian beach cove, and allows me to run my fingers through my strands without catching on tangles.
Achieving that kind of adjustability has led to chairs with tangles of unsightly levers and buttons that even expert ergonomists have trouble navigating.
Keep tangles at bay: "We all want to look like mermaids, but if you're swimming, you must put your hair up," says Capri.
By six months old, they were accumulating in the cerebral cortex as well—as were the tangles that are associated with neurological degeneration.
Weier awkwardly tangles herself into a ball shape as she tells the story of how she came to meet, fear, and respect Slenderman.
The buds themselves are milled from aluminum, but more importantly, OnePlus ensured you can magnetically snap them to each other to avoid tangles.
Researchers suspect the unusual plaques and tangles may be causing the disease or at the very least contributing to the death of cells.
The wires for the earbuds can retract to avoid tangles and the battery can last up to 16 hours on a single charge.
Wired headphones normally come with the hassle of tangles, but the Y-type flat cord of the Sony Extra Bass earbuds reduces tangling.
The GoPets Dematting Comb gently works through mats and tangles while also removing loose hair to reduce shedding in cats with all coats.Pros:
Inside the brain, Alzheimer's is associated with abnormal clumps known as amyloid plaques and tangled bundles of fibers, often called tau or tangles.
For the uninitiated, Merlan's book is a riveting tour through the tangles of some of the most prominent conspiracy theories in circulation today.
It would take another 80 years for scientists to identify what those deposits were: plaques and tangles of proteins called amyloid and tau.
Alternate route: The wireless streaming optionIf you don't want adapters and the tangles of a wired connection, streaming sticks are a reasonable option.
How languidly and grossly they intertwine with one another — how clumsily, lewdly, indiscriminately — like lascivious cephalopods merged in seething tangles of prehensile carnality.
We can remove a few of those tangles, but the cost to the U.S. economy of removing them all would be unacceptably high.
The poor, the elderly, the disabled and the jobless are increasingly prone to Kafka-esque tangles with the bureaucracy to keep public support.
And "Outlander" is clearly ready to put its tangles with race and colonialism behind for a while and settle into its settlers' lives.
We're used to the idea of sharks as predators in the open ocean, not creatures that stalk seals through tangles of sea grass.
The crisscrossing streams of vivid pigment on the canvas resemble the tangles of colorful wires that Cruz uses to connect his modular synthesizers.
In that time, there were hard personal choices and legal tangles with some of the most senior officials in Prime Minister David Cameron's government.
Beta-amyloid and tau are naturally occurring proteins in the brain that clump together in people living with Alzheimer's, forming plaques and tangles respectively.
"Tangles actually spread across the brain," said Skovronsky, whose colleagues at Eli Lilly have developed imaging technologies to identify their presence inside the brain.
During the presidential campaign, Trump promised to hire the "best people," but his international deals show his partners often had tangles with the law.
Many people with frontotemporal dementia also have inherited genetic mutations involving the production of tau, which greatly raise the risk of tangles showing up.
But the timing of the arrest tangles the issues as it came just as Presidents Trump and Xi reached a temporary trade war truce.
Irreversible after it begins, it's thought to be caused by a buildup in the brain of beta amyloid plaques and neurofibrillary tangles called tau.
A necropsy revealed her gut was also full of sharp shards of white, blue and pink plastic and tangles of blue and gray string.
Instead I'll talk about the two great sex-and-politics tangles of my adolescence, the Bill Clinton and the Clarence Thomas-Anita Hill scandals.
Companies like Qualcomm, Hewlett Packard Enterprise and Microsoft have also struck up Chinese partnerships in recent years to avoid political pressure or regulatory tangles.
The harnesses, tangles of thick straps and metal clasps that let tourists lean out over the skyline without worry, quickly became underwater death traps.
One candidate might be the astrocytes, cells that support the neurons and synapses, keeping them healthy even in the presence of plaques and tangles.
Alzheimer's disease, which is believed to be caused by a buildup of plaques and tangles in the brain, is the most common type of dementia.
Raghanti said it's not clear if the plaques and tangles found in chimps are producing the same level of cognitive decline as seen in humans.
There are plenty of hydrating salon-quality treatments (at all price points) that reverse the signs of stress — like dryness and tangles — on your hair.
Centrifugal forces suck up dirt and debris into separate (and easy to clean) chambers, while the combo brush collects stubborn pet hair with less tangles.
Hair of all colors, textures, and shapes line the space's second-floor gallery, including a nest of braids, buns, and other tangles salvaged from hairbrushes.
Without the source painting across the room, you might not make out the traceries of its composition through the tangles of linear and color notations.
Dimachki says hair that is highlighted, tangles easily after shampooing, or is prone to greasiness is also a prime candidate for a pre-shampoo conditioner.
Studies have shown that as these conditions progress, these proteins tend to form clumps (known as amyloid plaques and tau protein tangles) in the brain.
I apply just enough to marinate my split ends and glide through the tangles, only opting for extra when I plan to use hot tools.
Look long enough and you'll find the owl, which is much less distinct than certain oddly emphatic patches of tree bark and tangles of branches.
After spraying a generous amount through our mid-lengths and ends, we can still run our fingers through our hair without catching on tangles. Magic!
Our top pick is the Wet Brush Detangle Shower Brush because it's super affordable and it can get rid of tangles without hurting your scalp.
Some have focused on tau, a protein that, in Alzheimer's, forms threads that stick together in tangles inside neurons, sandbagging their communications with one another.
The underwater forests — huge, sprawling tangles of brown seaweed — are in many ways just as important to the oceans as trees are to the land.
That section still comes across like the fugue to end all fugues, with outbursts of sputtering rhythms, obsessively hammered attacks and tangles of wayward counterpoint.
In their variety of chroma and brushwork, they vigorously explore different tensions between the flanking planes of color and the tangles of line between them.
Making It In recent years, once-tidy bouquets have become boundless, their diverse tangles of blooms, branches and weeds looking ever more like art installations.
The accumulation of amyloid also stimulates an immune response, which causes another set of proteins (the tau proteins) to form tangles inside the nerve cells.
Upon entering the Halsey's galleries, one steps into the enveloping tangles of an oversized black garden, employing Ma's signature honeycomb paper structures and cultivated chaos.
Tearing apart the tangles Although they may be talked about more often, plaques are not the only theory among scientists to explain how Alzheimer's disease occurs.
The braided wire, like the rest of their construction, feels wonderfully strong and of a very high quality, but it tangles easily and is permanently attached.
Joleen Cummings, 133, was reported missing on May 13 by her mother and was last seen leaving Tangles Hair Salon in Fernandina Beach around 5 p.m.
No matter what course U.S. president-elect Donald Trump takes with China, he starts out with at least one loss in his tangles with Beijing authorities.
The commissioner, Victoria McKee, said using the embryos could violate the right not to be forced to procreate and create complex emotional tangles for the children.
When not in use, the earbuds magnetically attach to each other to help minimize tangles—the magnetic click also conveniently auto-pauses whatever you're listening to.
The deformation shears some axons directly, releasing their protein contents, including tau, which with time can form abnormal tangles similar to those found in Alzheimer's disease.
Stepping through the door, he saw every surface covered with junk: file folders, tangles of cords, external drives, SD cards, a voice recorder, and a Fitbit.
A week of disrupted sleep increased the amount of tau, another protein responsible for the tangles associated with Alzheimer's, frontal lobe dementia and Lewy body disease.
A week of disrupted sleep upped the amount of tau, another protein responsible for the tangles associated with Alzheimer's, frontal lobe dementia and Lewy body disease.
Northwestern looks to win back-to-back Big Ten road games for the first time in over a year when it tangles with Rutgers on Thursday.
ANGST OVER petrol prices, confusion over Britain's relationship with the EU, bemusement at the American president's legal tangles: it feels like the 1970s in Europe again.
Irreversible once it begins, the disease is thought to be caused by a buildup in the brain of beta amyloid plaques and neurofibrillary tangles called tau.
I mastered the staircases that connect old and new wings and the tangles of corridors that extend through the four-block-long, two-block-deep building.
Brain pathologies include the protein plaques and tangles seen in Alzheimer's disease, as well as the infarcts (small areas of dead tissue) seen in cerebrovascular diseases.
Behind parallel display cases, his cluttered workbench bears gold plating, tangles of wires, gun grips, rifles, and the weighted chisels and hammers El Gorupo made himself.
I, too, thought my story reflected an "idiosyncratic flaw" in me until I found news articles about other immigrants who landed themselves in similar legal tangles.
They worked to replicate the pathological evolution of the tau proteins that cause these tangles, giving neuroscientists and researchers a more thorough framework to develop treatments.
For readers who haven't been keeping up with the advice column in Styles — for 520 weeks and counting — that adds up to about 2,100 social tangles.
All are utterly starved for relief from the scattering tangles of PTSD, which can include symptoms of extreme paranoia, flashbacks, suicidal tendencies, dissociation, and night terrors.
He shows us deep under the hood, where he wrestles with the motors, high-powered batteries and tangles of electronics and cables that make Teslas tick.
Researchers have long speculated that plaques, and to a lesser extent tangles, are primarily responsible for the damage Alzheimer's causes, but not everyone agrees with that explanation.
The oil company has been locked in tangles with opponents of fossil fuels for months in fights that have spilled over into U.S. Congress and shareholder meetings.
Some may be experiencing the subtle signs of cognitive loss; others are still blind to growth of the devastating plaques and tangles destined to steal their memories.
She reportedly was last seen alive by coworker Kimberly Kessler, otherwise known as her apparent alias, Jennifer Sybert, who had been working at Tangles for a month.
The wooden slats of a shed flank the remains of the home on one side, and tufts of grass grow in tangles in front of the plot.
In human hairs, the cells end up winding around one another in complex tangles, which makes it difficult to draw conclusions about how they contribute to curl.
In composing this moralistic fable, Mr. Capra and his writers have tossed in a great abundance of colloquial incidents and emotional tangles of a mistful, humorous sort.
Blood clots, gelatinous tangles that can travel through the body and block blood flow, kill more people every year than breast cancer, AIDS and car crashes combined.
At one point, on "The Dick Cavett Show," Baldwin tangles with Paul Weiss, a Yale philosophy professor who scolds him for dwelling so much on racial issues.
These tangles of machinespeak are, to borrow a phrase from the eco-ontologist Timothy Morton, a kind of hyperobject—huge, diffuse entities that can't be pinned down.
Working with a team of colleagues, Dr Baker obtained a population of mice that had been genetically engineered to quickly develop fibrous tangles of protein in their brains.
ONE OF ELIZABETH WARREN'S formative political tangles, which prompted her move from law professor at Harvard to senator from Massachusetts, occurred in 2005 over a bankruptcy reform bill.
LMTX attacks the tangles of protein (tau) found in dying and dead nerve cells in patients' brains, a different approach from other Alzheimer's drugs currently on the market.
When scientists look at tissue from an Alzheimer's patient's postmortem brain, they see not only the unusual plaques and tangles but also surprisingly few brain cells and synapses.
In healthy brains tau protein normally helps brain cells to function but in the brains of people with Alzheimer's disease tau clumps up in tangles inside the cells.
It trades mostly outside the EU, but Mr Sarkar is opening a new company in Dublin to keep his European business free from any post-Brexit regulatory tangles.
What's next: The researchers hope that by imaging tau proteins in other diseases, they'll be able to see if they form similarly or differently than Alzheimer's tau tangles.
Beautiful, even; there is a quiet joy held within its tangles of notes, in the rise and fall of its drawn-out melodies and forays into technical ecstasy.
The most widely endorsed theory of the disorder is that beta amyloid is the principle bad guy, in part since plaques seem to show up before tau tangles.
Add to that a hard line on immigration, as well as potentially isolationist trade policies and a myriad of tangles over tech-favored social issues like gay rights.
There's even growing evidence that poor sleep early in life can lead to the development of the plaques and tangles that cause Alzheimer's and other kinds of dementia.
PowerLine cables are reinforced (Anker claims they last five or six times longer than other cables), and the PowerLine+ brand is encased in braided nylon to prevent tangles.
Researchers find signs of Alzheimer's in dolphin brains Later research identified the proteins that made up the plaques as amyloid and those that form the tangles as tau.
Those causes are brain infarcts (also called brain lesions) and the signature biomarkers of Alzheimer's disease: the plaques and tangles, both made of different proteins, in the brain.
Here and elsewhere, gaps in the figures' skin reveal bits of Abstract Expressionist brushwork or Pollock-like tangles of line, which may categorically be the show's worst idea.
Video of the collapse was widely shared on social media and the fire department posted photos of the aftermath showing crumpled floors and tangles of broken construction materials.
Being targeted by Trump is a new position for Cruz, who has taken the lead in some polls of Iowa Republican voters in part by avoiding tangles with Trump.
One possible explanation is that its earlier tangles with F1 in the late 1990s were scarring, evolving into the sort of bruising encounter it may be loth to repeat.
He'll lend a claw to Mario's cause when it suits him, but he's still an obsessive kidnapper of ladies who tangles with the mustachioed plumber on an annual basis.
Unlike Alzheimer's, the tau protein tangles of CTE appear in the brains of younger people and take over specific parts of the brain, regions typically not affected by Alzheimer's.
I mean, that's kind of the interesting thing about some of this stuff is that it... Copyright is weird because it tangles up what's sometimes personal with what's commercial.
ONE OF Elizabeth Warren's most formative political tangles, which prompted her transition from law professor at Harvard to senator from Massachusetts, occurred in 1003 over a bankruptcy-reform bill.
Solving endemic violence turns out to be rather more complicated than Luke had anticipated, and he quickly finds himself caught up in the political tangles of 21st-century America.
The FBI is looking for clues in the disappearance of Joleen Cummings, 34, who hasn't been seen since leaving her job at Tangles Hair Salon in Fernandina Beach, Fla.
So maybe, Condello said, those who survived longer had genetics that made their brains better at shoving the toxic prions into plaques and tangles than those who died young.
As it approaches its sixth birthday, Uber is finding itself in the news as much for its size and growth as for its tangles with unions and city politicians.
Alzheimer identified two kinds of protein aggregates that are not found in younger brains: plaques that are found between brain cells and tangles that are found inside brain cells.
And those fearsome black holes would be dense tangles of strings and branes crumpled together into a ball, like a wad of paper that is tossed into a wastebasket.
They crowded him in the back-court and collapsed on him when he got in the paint, forcing him to make his way through tangles of arms and bodies.
For strings of lights and garlands, use zip ties to avoid tangles and put them in plastic bags labeled according to use (tree lights, porch lights, balcony, bushes, etc.).
To minimize the weight of its payload, NASA has experimented with inflatable materials that can balloon into habitats, and tangles of lightweight rods that can shift shape on different terrains.
Acosta, who regularly tangles with Trump, has built a reputation for casting aside manners and protocol in order to get his often-rhetorical questions on tape for the evening newscasts.
With her tie undone, socks nearly down to her ankles, bow almost to the back of her head and her hair in tangles, it looked like Lucie hadn't held back.
Complex tangles of taxation and regulation contribute to what is known as the "Brazil cost": the added expense of doing business in Brazil over and above what it costs elsewhere.
To put it simply, people with Alzheimer's disease have brains that are filled with rigid, clumped-together deposits of the proteins amyloid beta and tau, called plaques and tangles, respectively.
It took 22013 years, one lawsuit, repeated tangles over Medicaid rules — and a chance meeting on a church van — before he could extract himself from a nursing home outside Baltimore.
But the woman had few other neurological signs of the disease — not much of a protein called tau, which forms tangles in Alzheimer's brains, and little neurodegeneration or brain atrophy.
Vital Theater Company is now reviving Sammy Buck and Daniel S. Acquisto's musical adaptation, which centers on a wad of gum in the hair and a lot of other tangles.
The side tunnel, though, is pitch black save for the helmet lamps, and the trek to the valve is a slosh through muck and over tangles of mangled electrical cabling.
It reduces beta amyloid (the signature plaque deposits seen in the brains of deceased Alzheimer's patients) and hyperphosphorylated tau (the signature protein tangles also seen in patients' brains), he said.
DAWSON'S FALL By Roxana Robinson Roxana Robinson's deeply reasoned sixth novel tangles with the nature of truth and conviction in a society split by racial violence and a runaway media.
But in last year's playoffs, the Raptors successfully walled off the paint, making Antetokounmpo navigate through tangles of arms and bodies any time he ventured inside the three-point arc. 
She also found that a week of disrupted sleep increased the amount of tau, another protein responsible for the tangles associated with Alzheimer's, frontal lobe dementia and Lewy body disease.
Both have an eye for the swerves and accidents — the kinks of fate and the tangles of desire — that so often determine the destinies and undermine the intentions of individuals.
No visitor to a place where they are common, like Vietnam, India or Pakistan, is more likely to be appalled — and intrigued — by these Gordian tangles than a traveling engineer.
To play the Israeli adventurer Yossi Ghinsberg, Mr. Radcliffe dives into water and quicksand, slathers himself in fire ants, tangles with a snake and excavates a parasite from his forehead.
A new study published this week in Alzheimer's & Dementia is now the first to find two key markers of the disease—protein plaques and tangles—in a wild animal, namely dolphins.
Bladders empty too often, bowels not often enough, and toxic proteins build up in the brain to form the plaque and the spaghetti-like tangles that are associated with Alzheimer's disease.
Rio's fly lines are extra slick, which lends them to fewer tangles, and with loops at both ends, they'll save you a lot of time when it comes to tying knots.
The drug, called LMTX, is the first one with its mode of action — trying to undo so-called tau tangles in the brain — to reach the final stage of clinical trials.
The only way to definitively diagnose Alzheimer's is still after someone has died and their brain can be examined under the microscope, looking for the telltale amyloid plaques and tau tangles.
Critic score: 80%Audience score: 54%Netflix description: " In 1905, a drifter on a dangerous mission to rescue his kidnapped sister tangles with a sinister religious cult on an isolated island."
This also happens with the plaques and tangles of Alzheimer's disease: some people's brains are found to be riddled with them, even though they showed no evidence of dementia while alive.
Steven Spielberg himself will direct, with Harrison Ford reprising the titular role of archaeology professor-turned-adventurer who tangles Nazis, Commies, and ghosts to preserve history that belongs in a museum.
A routine five-year renewal of his security clearance in 2012 should have covered all his legal tangles and the breakup of his two marriages, in the late 1990s and 2010.
Calligraphy serves instead as the genesis of Mr. Marden's abstractions, which deform and reform in rhythmic, liquid tangles, often overlaid with white gouache that acts as erasure and emendation at once.
"They have greater accumulations of plaques and tangles in the brain, the biomarkers of Alzheimer's disease, and a reduced size of the hippocampus," the part of the brain associated with memory.
Aziz Ansari and Alan Yang's Master of None is about all the weird tangles that come with being on the cusp of 30 with only a tenuous idea of what's ahead.
Dig Deeper ProPublica — The Pulitzer prize-winning nonprofit is known for its in-depth investigative journalism, invaluable explainers and informative databases that demonstrate the tangles of interests at play in everyday institutions.
Since their hair is so similar to human hair, it tangles in the same way and requires daily brushing, but on the plus side, they only shed as much as humans do.
I'm usually wary of any machine that is meant to vacuum up my hair (hello, tangles are a real concern), but this left me with loose curls that were red carpet worthy.
The findings are the first from a large-scale trial of a drug that targets the Alzheimer's-related protein tau, which forms toxic tangles of nerve fibers associated with the fatal disease.
While several officials say Trump is generally pleased with Sanders' performance, particularly how she tangles with reporters in the briefing room, the President believes he is the best voice of his administration.
Air-dried hair, unless you're very lucky, is normally associated with frizz or flatness, tangles or flyaways — and certainly not the bouncy curls, smooth waves, and shiny strands many of us prefer.
This is hell on car-company executives, but Trump and the administration's tangles with the automakers play well, particularly if California — a renegade kingdom of blue — can be brought into the fight.
There is no simple way to tell the story, and Ms. Portman's film, closely based on a memoir by the Israeli novelist Amos Oz, is full of mixed emotions and chronological tangles.
Kaplan's interests run wide: the ethnic tangles of Central Asia; the political thought of Samuel Huntington; the unsung heroism of Medal of Honor winners; the prospect of war on the Korean Peninsula.
Sometimes wide, with two-lane traffic, the drive splits into tangles of smaller streets of the same name, some of which are as narrow as country lanes, as at West 97th Street.
But Dunkel's team hopes the findings will play a role in designing new ways to tie, loop, twist and otherwise form tangles from rope, adding a new predictive dimension to knot theory.
Tangles of tree branches blocking passage and the tricky climb notwithstanding, the unspoiled remoteness, the wild, the silence, all illustrated to me that we were happily far, far from the beaten path.
Adding to the tangles, some senior Republicans left Mr Comey's testimony unchallenged and instead argued that Mr Trump did not know how to talk to FBI bosses, because he is new to politics.
Beta-amyloid is believed to be more directly linked to the early progression of Alzheimer's, but by the time the disease is fully recognizable in someone, both tangles and plaques litter the brain.
From there, Tanzi's work has shown, the plaques trigger the production of tangles—clumps of another brain protein called tau seen in the later stages of Alzheimer's—which together then trigger chronic inflammation.
She tangles with Bruce Wayne as he investigates someone known as the White Portuguese, giving the moody billionaire some much needed levity; then shows up in a huge way for the big battle.
McCabe's tenure under Trump was marked by frequent tangles with the president, particularly after McCabe rose to acting FBI director in May 2017 following the firing of James Comey, Trump's first FBI chief.
But unlike the flimsy combs of drugstore dryers, the bristles on the firm brush attachment were super strong and could easily take on my Afro hair, sliding through any tangles and snags seamlessly.
Also part of the Monuments installations, a piece by Parker Ito, at the fair with Château Shatto, dangles numerous punctured bodies of an old-timey mascot from tangles of chains and wire lights.
Judicial rulings regularly halt energy and mining operations in countries including Colombia, sparking worries that legal tangles would spook foreign investors as many Latin American countries battle high inflation and slowing economic growth.
If you're waiting for Apple to update AirPods so you can finally buy them and put cable tangles behind you once and for all, you might be holding out until later this year.
When a lost baby seahorse winds up in his care after a series of mishaps, Bojack discovers an innate paternal instinct as he tries to navigate the child through rainbow tangles of kelp.
I quickly lost track of where we were as we drove through canyons of high-rises and tangles of highways, occasionally glancing a prominent throw-up or a tag on a roadside structure.
In the Prokofiev, she dispatched the tangles of passagework, pummeling chords and arm-blurring bursts of octaves with excitingly effortless virtuosity, while also highlighting the music's moments of lyrical richness and poetic musing.
To end, the intrepid players (Mason Yu and Erica Tursi, violins; Jinsun Hong, viola; Alex Cox, cello) tore through the contrapuntal tangles of Beethoven's Grosse Fuge, a fearless rendering of this astonishing piece.
Dr. Lee and her team developed the tau hypothesis, which posited that the cellular tangles found in the brains of Alzheimer's patients might themselves be the cause of the neurons not firing properly.
At the Fridman booth in the Presents section, the painterly lines of Wura-Natasha Ogunji's sewn and inky multi-panel work "Unfinished" (2020), beckoned me closer to its enchanting tangles of indigo thread.
These SENSO Wireless Sports Earphones are specifically designed to stay put by wrapping around your ear with a secure and waterproof fit, free of tangles and the need for mid-run wire adjustments.
Vital Theater Company has revived Sammy Buck and Daniel S. Acquisto's musical adaptation, which closes on Saturday and centers on a wad of gum in the hair and a lot of other tangles.
" A susceptibility to neuroinflammation is key, Tanzi says, "because at the end of the day, plaques and tangles may set the stage, but it's neuroinflammation that kills enough neurons to get to dementia.
Rays of sunlight shine through many of her underwater photos, creating romantic spotlights with striking contrast to the murkiness of the water and the dark tangles of seaweed and shellfish surrounding her subjects.
It suggests that the other worlds to explore—that "infinite truth"—were right there inside her all along, waiting to be shaken loose from the twists and tangles of her own vocal chords.
The first of these new matchups will take place in the light heavyweight division, as The Ultimate Fighter 17 veteran Clint Hester (2197-215) tangles with Brazil's Marcos Rogerio de Lima (23-26-21).
Think of this detangler as a pre-emptive strike — the product is meant to be used before you shampoo, so single-strand knots don't turn into irreversible tangles as you massage your scalp clean.
It was on New Year's Day of this year that 7-year-old Gianessa Wride's hair first started falling out in quarter-sized clumps as her mom brushed through her tangles in the morning.
He doesn't know if he has CTE, but he has shown me an experimental scan of his brain, and there are bright red tau tangles in all of the areas consistent with the disease.
As we have seen with the current Zika funding battle and previous tangles over Ebola, passing legislation to fund Centers for Disease Control and Prevention coordination and response can take weeks, if not months.
In other instances, the combination indicated a loss of interest, as with Lucian Freud's great "Self-Portrait Reflection, Fragment," in which tangles of drawn lines form a scaffolding around the artist's seemingly finished face.
For a very different but no less stellar display of clay, visit Geary Contemporary's booth, where the powerful and prickly totems and tangles of glazed ceramics by Heidi Lau are a delight to behold.
I spent the better part of a year wrangling tangles and bends, trying and failing to make even coils after use, and soon enough, wrapping plumber's tape around numerous dripping punctures, cracks, and tears.
In a handful of cases, picking through the tangles of information, true and otherwise, that shaped the election, it was possible to isolate a single strand that could be traced to Russian news sources.
You cannot predict how the plaques and tangles in an Alzheimer's patient's brain will change him or her: A taciturn mother becomes chatty, a father forgets his daughter, a prim grandmother takes up obscenities.
Headlines for state attorneys general (AGs) have been dominated by tangles with the Trump administration — from the travel ban case going to the U.S. Supreme Court to challenges to legacy regulations at federal agencies.
Johnson's No More Tangles spray is specially formulated to untangle the hair of toddlers, who begin losing their fine baby fluff at age 2 or 3 and grow thicker, knot-prone locks in its place.
But those who said they ate seafood one or more times a week also had less Alzheimer's-related brain pathology, such as plaques or neurofibrillary tangles, compared to those who ate little or no seafood.
Byzantine tangles of water pipes and gas lines and electrical cords that would have mystified a contractor somehow managed to pump the atrium with warm air and fresh water, insulating it from the Detroit winter.
Sure, there are still a number of contractual tangles to overcome for McGregor to actually fight anyone inside a boxing ring, but a move to make that prospect any more possible is a bold one.
They also looked at clinical assessments of the patient taken before they died to see the trajectory of their cognitive decline and pathology assessments after they died to check the severity of plaques and tangles.
From LGBTQ people sharing their stories to individuals using letters to work through the tangles of their thoughts, a thread now connects a 1980s theory to thousands of people addressing their mental health with letters.
These methods allowed him to create surprisingly expressive images whose stringy tangles of acidic blues, greens, reds, yellows, and black resemble everything from jelly-fish and reptile skins to swirling galaxies and mutant, otherworldly plants.
Then again, there were complex tangles, like his late opera "La Mère Coupable" ("The Guilty Mother," 1965), a work chock-full of musical busyness, with the instruments often going one way and the singers another.
Research from last year showed that older people with higher-than-average blood pressure was linked to more tangles in the brain tissue, a common sign of Alzheimer's disease -- the most common form of dementia.
For decades, most researchers have agreed that these plaques and tangles are the key malefactors of dementia, and that if you could clear them from the brains of patients, you would halt or reverse illness.
In someone with the disease, both types of proteins constantly accumulate, break apart, spread to different parts of the brain, where they accumulate again, eventually forming hard-to-remove clumps known as tangles and plaques, respectively.
During a background briefing on Monday, an administration official said that the time lapse was due in part to the legal tangles prompted by federal judges who were "substituting" their judgment for that of the executive.
FIber-like clumps of tau called tangles, seen above, are abundantly found in the brain of someone with Alzheimer's diseaseImage: Patho (Wikimedia Commons)It's often true that broad groups of people can experience a disease differently.
Kessler, who worked with Cummings at Tangles Hair Salon in Yulee and was allegedly the last person to see her alive, has been in custody since June for grand theft auto for allegedly stealing Cummings' car.
Shiny black ceramic sculptures, resembling pelicans covered in oil, nestle in areas of live bright green grass along with rocky forms, which, like the birds, apparently were cast in clay from compressed tangles of thick rope.
Her sculptures, which often feature tangles of eyeballs and teeth, look as if the innards of some strange creature have been turned inside out and are now looking to consume whatever lies in their general proximity.
The R1001AE also has the most powerful suction of all the Shark R-model devices, a self-cleaning brush roll (no more hair tangles), and total home mapping that basically memorizes the layout of your space.
Some of the other connections made in "Lifestyle Wars" feel trite: in particular, the ant farm as nature's equivalent of the data-processing center, a connection reinforced by stacks of server cases and tangles of Ethernet cables.
I hiked around and found mattress frames, tangles of rusty wire, an old oven, a sink, water tanks, an old stovetop range, a collapsed corral, metal drums, a couple of concrete pads and a large mining contraption.
Images from there showed swaths of shattered debris where houses once stood and structures inundated up to their rooftops; the streets of Panama City, farther west, were blocked by downed tree limbs and impossible tangles of power lines.
In addition to plaques and tangles, other potential villains found in the brains of people with a diagnosis of Alzheimer's include silent strokes and other blood vessel diseases, as well as a poorly understood condition called hippocampal sclerosis.
And as he and Alma navigate the tangles of their shared life, it captures the stark nihilism we sometimes face, especially at the end of the year when we suddenly take stock of all our blessings and curses.
Knitting needles, tangles of golden chord, blue and white trinkets and plinths, allude to a kind of silent music sheet, the reading of which relies on an internal dynamic system that extends far beyond the formalism of sculpture.
Germany's biggest lender, struggling to extract itself from regulatory and legal tangles that have already cost it billions of dollars, announced late on Thursday the resignation Georg Thoma, a top financial lawyer who headed the supervisory board's Integrity Committee.
During the process of interpreting the tangles of stinkweed, crumpled chain link fences, and haphazard façades reaching for sneaker-festooned power lines, Brown began to see Marie Antoinette's piled hair — and from that bewildering epiphany the aforementioned shift followed.
That means it can be repurposed for use in individuals who get diseases related to tangles," Kosik said "Once you're doing human trials, they should be done with people with very mild disease or even before they show symptoms.
Just for a moment, though, put aside Musk's aborted plans to take the company private; his ill-advised tangles with the SEC; out-of-left-field cave rescue missives and insults; bizarre interviews; pot smoking; and on and on.
From the trailhead, we passed stands of giant bamboo and vast tangles of chayote squash, which grows wild throughout the wet, eastern side of the island, and followed switchbacks carved into a cliff face up to the Bélouve Forest.
Amyloid plaques are starch-like deposits found outside nerve cells, and neurofibrillary tangles are hair-like clumps found inside nerve cells, and the traditional thinking was that these deposits led to nerve cell death and ultimately, symptoms of Alzheimer's.
Alzheimer's disease can be definitively diagnosed after a patient dies by looking at sections of the brain under a microscope which can reveal the presence of amyloid plaques and neurofibrillary tangles, structures in the brain unique to this disease.
It would be beyond stupid and incredibly short-sighted for Apple to do this and, if it was actually true, would likely lead to tangles of a governmental and legal nature that no company like Apple would ever want to happen.
Many of the transactions recorded on that distributed ledger are crimes: Billions of dollars in stolen funds, contraband deals, and paid ransoms sitting in plain sight, yet obscured by unidentifiable Bitcoin addresses and, in many cases, tangles of money laundering.
"When the tongue glides over fur, the hooks are able to lock onto tangles and snags," lead author Alexis Noel, a PhD candidate in mechanical engineering who presented her research at a physics conference this month, explained to the Washington Post.
The accumulation of another protein called tau—known as tangles—might damage the brain and cause the symptoms of Alzheimer's too, but the flooding of amyloid beta is thought to show up first and drive the progression of the disease.
Germany's biggest bank, struggling to extract itself from regulatory and legal tangles that have already cost it billions of dollars, announced late on Thursday the resignation Georg Thoma, a top financial lawyer who headed the supervisory board's Integrity Committee [nL5N17W22O].
While her past efforts have included her voice as a piece of the cybernetic collagework, this record is the first on which she's chosen to foreground her unique gift for pulling unexpected sounds out of the tangles of her vocal cords.
The hire, of course, comes at a propitious time for Apple, as it tangles with the FBI over a court order that could force the company to break the security of an iPhone used by one of the San Bernardino shooters.
While Washington tangles with Beijing, it is also trying to resolve the renegotiation of the North American Free Trade Agreement as well as resist overtures to join the Trans-Pacific Partnership that includes countries such as Japan and New Zealand.
Arvanitakis and her colleagues also discovered that higher systolic blood pressure was associated with a higher number of tangles in the brain tissue, a common sign of Alzheimer's disease -- but not amyloid plaques, another common feature of the neurodegenerative disease.
He was also sidelined from urban planning and saw both Phnom Penh and the resort town of Siem Reap, which he had helped to lay out, become tangles of streets lined with hastily erected concrete buildings and blocky condominium towers.
Such a reconciliation, if accomplished, would require the church to explicitly cede a share of its authority to appoint bishops to the Politburo — a concession familiar from medieval church-state tangles, but something the modern church has tried to leave behind.
From a distance, to the unaccustomed eye, heaps of seaweed on a white sand beach can look like burst garbage bags, while the slippery tangles adhering to rocks seem nothing more than a potential hazard to the casual shore-stroller.
Stella's vision has plunged irretrievably into the Baroque, and his tangles of pattern, line, color, and shape can be as mind-bending as they are exhausting, like an exegesis from a brilliant speaker who doesn't know when to shut up.
Walker, Google SVP and general counsel, has already been a public voice in the company's recent privacy tangles, but will move into a formal role as senior vice president of global affairs, overseeing Google's policy, trust and safety, corporate philanthropy and legal teams.
We follow Johnson as he signs on with Marsh's expedition, goes West, is recruited by Cope for his expedition, tangles with native tribes, outlaws, and miners, all as the scientists make some incredible discoveries in the rocky slopes of the Montana Badlands.
But given this (gen-1) VR experience requires wearing a weighty headset over your eyes while walking in a small space tethered to a cable that easily tangles with your feet it's hardly surprising to come away feeling more fettered than liberated.
The number of concept and venue changes that plagued the artist in the development of this work probably caused more than a few blood pressure spikes among audience members, many of whom were artists that have had their own share of bureaucratic tangles.
They consist of Ebony Maw (the character who fights Doctor Strange), Proxima Midnight (the spear-throwing character who tangles with Black Widow and Okoye), Corvus (the villain who stabs Vision), and the Black Dwarf (the hammer-chain-wielding muscle of the group).
Most problematic, and accounting for half of the plastic mass in the gyre, are what sailors call ghost nets: great tangles of mile-long discarded fishing nets weighing as much as two tons, which can ensnare animals such as seals and sea turtles.
In the past, the Trump Organization has hit back at legal tangles, including a lawsuit lodged last year by Diane Gross and Khalid Pitts, the owners of the Cork Wine Bar, who claimed that the hotel was taking business away from them.
Claire Falkenstein (1908-1997), who, outside her native California, has never had a full-scale retrospective in this country, is generally known for her exquisitely excessive sculptures dating from the mid-1950s — welded metal tangles embedded with bright pieces of Venetian glass.
The kaleidoscopic volume inspires genuine awe, both at the intricacies of our biology — Gordian tangles of lymphatic vessels, the roller coaster topography of the tongue — and at the technical finesse, empathy and humor artists have brought to the complex task of depicting them.
Nowadays, since most of us live in more sterile environments, this army in our brain is no longer busy fighting pathogens, and so it responds instead — often far too vigorously — to the amyloid plaques and tangles that are a part of normal aging.
Star Wars Propel Drone: Collector's Edition — $21080 with code NEWYEAR224.29 See Details Made with ultra-durable braiding to prevent tears and tangles, the high-speed Triton cable is outfitted with USB to Lightning, USB Type-C, and micro USB connections for convenient, uncluttered charging.
So when I heard that Kérastase was launching a "sugar spray" that had all the benefits of salt spray (added volume, loose texture, a piece-y finish) with none of the downsides (crispy lengths, tangles, flat ends), I decided to give it a whirl.
After controlling for age, sex, education and other factors, the researchers found that compared with those who ate less seafood, ApoE4 carriers who had one seafood meal or more a week had lower densities of the amyloid plaques and neurofibrillary tangles typical of Alzheimer's disease.
After shooting just 26.1 percent in the setback, South Carolina will look to take advantage of a much-needed three-day rest as it tangles with a Mississippi State team that has dropped five of seven - most recently a 98-92 setback against host Auburn.
Cryan, a Briton who took the helm of Germany's flagship lender in July, has been working to restructure the business and end a raft of regulatory and legal tangles that helped push it to a record 7 billion euro ($8 billion) loss last year.
But even as Puerto Ricans struggled without electricity to clean up and dig out from tangles of rubble, uprooted trees and fallen power lines, another potential disaster was unfolding in northwestern corner of the island, where a dam was on the verge of collapse.
The rush of the now in Uzbekistan is as strong as anywhere else, even as it tangles with history: Tashkent is a modern, strikingly clean and green capital with a metro system that doubles as an art gallery, each station more beautiful than the last.
Questions surrounding Ukraine It's unclear if and how the Kilimnik-Manafort peace plan episode might relate to Trump's more recent tangles with Ukraine, which involved his Mueller-investigation personal attorney Rudy Giuliani's dealings there and led to his impeachment by the House of Representatives.
The new mandate is likely to make Mr. Erdogan an even more difficult NATO ally, one who cozies up to Russia, buys Russian missile defense systems and a Russian nuclear reactor, and tangles with the United States over the Kurds in Syria and Iraq.
But whereas Giacometti is looking at his subject when he draws, not at the paper, you have the feeling that Leaf's is tuning in to her mind's eye, and that the figures that emerge from the tangles of lines came from her imagination or memory.
I'm not particularly crazy about aesthetics—my bedroom floor is currently covered with a nice, healthy layer of clothing and detritus—but when it comes to the charging cables of the various gadgets I own, I inevitably find myself deeply irritated by their rubbery, Medusa-esque tangles.
The formation of plaques is believed to occur much earlier than the formation of tangles, so many scientists have been trying to develop drugs to clear the brain of plaques, explained Dr. Ganesh Babulal, a researcher in the department of neurology at Washington University in St. Louis.
While tau tangles do show up later in the disorder's development, some research has shown that the spread of abnormal tau correlates better to the visible progression of the disease than amyloid (by contrast, plaques can be found in the brains of people with no visible dementia).
Verdant hillsides that had provided estates with a sense of seclusion were largely denuded by last month's historic wildfires, making them vulnerable to the massive mud and debris slides that sent boulders crashing into homes, turned highways into raging rivers and shredded cars into tangles of metal.
This whole song and dance of self-promotion, the thing where you go talk to the New York media, is new to Z-Ro, whose career, despite tangles with labels and all manner of interpersonal drama, has mostly just happened—and happened to mostly work out.
Ardent believers in Mr Mueller, a craggy faced former FBI boss under Republican and Democratic presidents, hope for a day when the super-prosecutor sweeps aside the tangles of partisan claims and counter-claims and lays criminal charges against those guilty of aiding and abetting Russia.
In an interview, Mr. Giuliani said that he had spoken at length with Mr. Trump, but that the president had wanted to move on from legal tangles to other topics — including the golf game that Mr. Giuliani was playing at a course in Scotland on Wednesday.
Jo faces an internal struggle between following her dreams to be a big-city writer and the societal pressure to be a wife and mother, Meg tangles in jealousy and hurt, and Amy delivers a clear-eyed analysis of what is most important in a marriage.
In a recent study of over 5,000 American adults between age 60 and 89 years published in JAMA Neurology, there were significantly more people with biologically defined Alzheimer's, with plaques and tangles visualized on brain-tracer scans, than there were people with clinical Alzheimer's disease, exhibiting symptoms.
For example, we don't know what exactly regulates the toxic build-up of amyloid-β plaques and tau tangles in the brain that are found in Alzheimer's patients, which specific types of these are toxic, or why the disease progresses at different rates in different people.
What is known: More women (22401/23) than men get the disease, there are genetic risk factors, and there are 2520 hallmarks — brains show increased beta-amyloid proteins leading to "plaques," there are large numbers of tau protein creating "tangles," and neurons are lost accompanied by brain-size shrinkage.
While I don't recommend braid to every angler (especially a novice prone to tangles), if you do plan to fish with braided line, it may be worth considering stepping up to something along the lines of Tsunami's Airwave Elite series, but again, I haven't had any trouble at all.
It covers beautiful and rugged terrain, including achingly steep inclines (and those are after the roughly 700 stairs near the start), chaotic trap-door drops into Muir Woods, and tangles of single-track trails over rocks and roots and through thickets of poison oak, among other nasty elements.
A 67-year-old retired teacher with Alzheimer's disease pathology, overweight, sedentary, with emphysema from smoking, strokes and heart disease will progress very differently from my tennis-playing, 67-year-old attorney patient without any heart problems -- even if they had the same amount of plaques and tangles.
"The kaleidoscopic volume inspires genuine awe," Zoë Lescaze writes in her review, "both at the intricacies of our biology — Gordian tangles of lymphatic vessels, the roller coaster topography of the tongue — and at the technical finesse, empathy and humor artists have brought to the complex task of depicting them."
The company faces a long list of legal tangles, including the lawsuit from Waymo that alleges trade-secrets theft; a class-action lawsuit from drivers; and a number of federal investigations that span possible bribery of foreign officials in Asian countries and the use of software to evade regulators.
After a political career built on youthful charisma and the access and privilege that comes from being part of a political dynasty — Trudeau's father Pierre was Canada's prime minister during 2350 years in the 2000s, 2300s and 2000s — Trudeau's tangles with Trump ensured that his political honeymoon was over.
The perspective from Scarborough, a former GOP congressman who frequently tangles with Trump, comes after the crowd booed and chanted "lock him up" when the president appeared on the scoreboard at Nationals Park Sunday night in Game 5 of the World Series between the Houston Astros and the Washington Nationals.
Deutsche Bank, struggling to cut through the slew of legal tangles and adapt its business to a more highly regulated, low interest rate banking environment, needed to put in place a new strategy and then find the right leaders to execute it, rather than the other way around, Achleitner said.
But despite her efforts to resolve key conundrums of Brexit among fellow political captains, it is below decks in the office cubicles of the Commission's Berlaymont building and in similar mundane engine rooms in London and other EU capitals that the legal tangles of this most complex of divorces will be unwound.
In the New York case, the House Financial Services and Intelligence committees requested a large swath of Trump family and business records from Deutsche Bank and Capital One bank in April, saying they need the records to consider banking policy revisions and to investigate the President's financial tangles with foreign powers, such as Russia.
The titular problem itself is barbarically convoluted; It tangles together pieces of the past — the Holmes' siblings childhood, Eurus and Moriarty, an old murder case — with current events at Sherrinford and the little girl trapped in an unmanned airplane, sipping her free juice box like it isn't probably the last thing she'll ever drink.
Spare and simple objects, such as leaves, vases, tubes, rocks, and dirt, agglutinate in her still life photographs into more complex, interrelated wholes; in the box sculptures, found industrial objects — for example, a mining axe; a car engine heating coil — are covered in tangles of rope that resemble a game of cat's cradle gone awry.
Sundays were my most hated day of the week as a child, because that was the day my Puerto Rican mother took me, her half-Black daughter, into the bathroom and spent a good hour on her knees wrestling the tangles out of my crazy-thick, waist-length curls as I sniffled and tried to control my sobs.
What they did: The scientists, working at the Medical Research Council Laboratory of Molecular Biology in Cambridge, UK, and the Indiana University School of Medicine in Indianapolis used a technique called cryo-electron microcopy or cryo-EM to image tau tangles from the brain of a 86-year-old woman who died while ill with Alzheimer's.
Whether it's a hair dryer that delivers a sleek blowout in minutes, a curling iron that elevates our tresses to Hollywood bombshell status, a flat iron that straightens without frizzing, or a good old fashioned hairbrush that cuts through tangles like nobody's business, we've scoured the lands (and the Internet) to bring you a roundup of the best hair tools on the market.
That's a signal that its partnership strategy appears to have been the better option for the older payments service as it tangles with Apple, which has the advantage of owning the hardware, the OS, and has a big stash of customers' credit card information, thanks to its App Store and growing line of subscription services, like Apple Music and iCloud.
Throwing its protagonists into the maelstrom of 1950s Cuba, her debut was split between sugarcane plantations in Oriente Province and political agitation in Havana: A French man sells weapons to the highest bidder and tangles with a mysterious zazou dancer named Rachel K., while across the country, two children grow up in the colonial world of the virgin banana daiquiri and Xavier Cugat at the Cabaret Tokio.
In some of the spiral-bound sketchbooks, large and small, that Miyawaki showed me at his Kyoto gallery, every page contained a strange drawing — of heads with numerous, oddly placed eyes and mouths, from which pointy tongues dangled; fragmented human figures and stingrays caught in tangles of thick, linguine-like lines; guitar players; a woman (the artist's mother) positioned near or seated on a toilet; and lounging cats.
Boston University researchers haven't just diagnosed CTE in the brains of deceased former NFL and college football players; they've seen the disease's telltale tangles of a neuron-killing protein called p-tau in six athletes whose gridiron careers ended in high school, including Nathan Stiles, a 803-year-old who died from a football-induced brain bleed, and Paul Bright, who died from injuries sustained in a motorcycle accident at age 24.
The Museum of Sex brought on Maggie Mustard, a specialist in Japanese photography, to co-organize this show (with Mark Snyder, the museum's director of exhibitions), and "The Incomplete Araki" tangles with the photographer's debts to Japanese literary modernism, the line between art and vulgarity, the West's fetishization of Asian women, and the power relationships between photographer and model — which, to use a word Mr. Araki will appreciate, can get very knotty.
Click here to view original GIFThe team's model of how the build-up of tau happens in the brain of someone with Alzheimer'sGIF: Ellen Kuhl (Physical Review Letetrs)There are still many questions concerning why these first seeds of misfolded proteins show up, how they convert more proteins to go rogue, and how they actually destroy the brain (more recent research has suggested it's the earlier stages of amyloid and tau buildup, not plaques and tangles, that are the most toxic to brain cells).
Two of the league's most impressive point guards will take center stage when fifth-seeded Oklahoma State tangles with No. 623 seed Iowa State on Thursday in the quarterfinals of the Big 12 tournament in Kansas City, Mo. The Cowboys' Jawun Evans leads the conference in assists (6.3), ranks second in scoring (18.7) and fourth in steals (1.9), while the Cyclones' Monte Morris joined Evans on the All-Big 12 first team, averaging 16.2 points while sporting a NCAA-best 6.2 assist-to-turnover ratio.
In addition to the oversize, Alice in Wonderlandesque paper blooms Rittson-Thomas makes for the shop, the studio's offerings have expanded from what her garden can provide seasonally — fruit blossoms in the winter, cow parsley, hyacinths and hellebore in the spring, dahlias and cosmos in the fall and tangles of sweet peas in the summer — to the flowers she finds at the Covent Garden flower market and from select purveyors including the English rose specialist Tempest, who provides stock to a very small circle of clients including 5 Hertford Street, a London social club known for its spectacular arrangements.
Bella Cankurtaran from Wilmington, N.C., closely read the image as inspiration for a poem: Spinning through the black abyss Bursts of light dot the universe outside my window My heart longs for your light I steer ahead into the route of the unknown The thoughts of you cloud my head Like the clouds I see below me My heart wants to be home A web of dread tangles my thoughts Wraps up my happiness Consumes it in one bite My heart wants to be free I am left with my own bitter sorrow For someone planets away For someone all alone My heart wants to be with you After reading the article, I found that Jakub, the astronaut, was having marriage issues with his wife, Lenka, down on Earth.

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