He was a quadruplet and he wanted to be a veterinarian.
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It was Nick Wade's idea to write about being a quadruplet.
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Quadruplet mother only seems to have three babies chilling in her uterus.
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Quadruplet brothers from Ohio have been accepted by Harvard and Yale, among other top schools.
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"I said, 'Yes, that's good, but you can't just leave it at, "Oh, gee, I'm a quadruplet.
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Since being born at the site on June 15 the quadruplet cubs -- two males and two females -- have been secluded indoors in their litter box.
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Fantastic four Lots of decisions have to be made in the Wade household, now that the family's quadruplet brothers have all been accepted to Harvard, Yale and Duke.
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The outburst was intended for 10-year-old fraternal quadruplet brothers, who have achieved notoriety for posting music to their ZN8tion Instagram account, which boasts over 143,000 followers.
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Because your sign is the sign of abundance, you're more likely a part of a triplet or quadruplet situation, but anyway: Who are you sharing your time with, and how is it working for you, Sag?
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Gestalt looks like a set of quadruplet siblings: one set of identical twins who go by Teddy and Alex (both played Jon Fletcher), and one set of fraternal twins who go by Eliza (Catherine Steadman) and Robert (Ronan Raftery).
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After losing their second child, Shanna, to a congenital heart defect three months after she was born, Jason and Clarissa Osborn of Spanish Fork, Utah, were overjoyed six months later to learn that they were expecting quadruplet daughters with the help of infertility treatments.
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VIDEO: Quadruplet Dad Carlos Morales Reveals Emotional Moment When One of His Kids Spoke Their First Word Miller delivered the little ones by caesarean section — Turner told Today that the births went "amazingly well" — and the babies will remain in the hospital's Neonatal Intensive Care Unit until they grow stronger.
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Quadruplet brothers choose to attend YaleBest dressed from the Met GalaLongest-living human ever - maybe - dead at 146 And he told Bloomberg news that he would be willing to meet with North Korea's Kim Jong Un — which, if it happens, would be the first time a U.S. president has met with a leader of the hermit nation since the Korean war.
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In June 2019 Peter Kaiser announced a 1,534 digit quadruplet with 19299420002127 × 25050 \+ 17233. In October 2019 Gerd Lamprecht and Norman Luhn announced a 3,025 digit quadruplet with 121152729080 × 7019#/1729 + 1.
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Sexy prime quadruplets (, +6, +12, +18) can only begin with primes ending in a 1 in their decimal representation (except for the quadruplet with 5). The sexy prime quadruplets below 1000 are (, , , ): :(5,11,17,23), (11,17,23,29), (41,47,53,59), (61,67,73,79), (251,257,263,269), (601,607,613,619), (641,647,653,659). In November 2005 the largest-known sexy prime quadruplet, found by Jens Kruse Andersen had 1,002 digits: : 411784973 · 2347# + 3301. In September 2010 Ken Davis announced a 1,004 digit quadruplet with 23333 \+ 1582534968299. In May 2019 Marek Hubal announced a 1,138 digit quadruplet with 1567237911 × 2677# + 3301.
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Leon Bankoff has constructed other Archimedean circles called Bankoff's triplet circle and Bankoff's quadruplet circle.
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The prime quadruplet {11, 13, 17, 19} is alleged to appear on the Ishango bone although this is disputed. Excluding the first prime quadruplet, the shortest possible distance between two quadruplets {p, p+2, p+6, p+8} and {q, q+2, q+6, q+8} is q - p = 30. The first occurrences of this are for p = 1006301, 2594951, 3919211, 9600551, 10531061, ... (). The Skewes number for prime quadruplets {p, p+2, p+6, p+8} is 1172531 ().
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In 2010 the group of Jason W. Chin presented a further optimized version of the orthogonal ribosome. The Ribo-Q is a 16S rRNA optimized to recognize tRNAs, which have quadruplet anti-codons to recognize quadruplet codons, instead of the natural triplet codons. With this approach the number of possible codons rises from 64 to 256. Even accounting for a variety of stop codons, more than 200 different amino acids could potentially be encoded this way.
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For example, the four-pillar quadruplets for 1984-3-18 and 2044-3-3 are exactly the same (i.e. 甲子-丁卯-辛亥-xx) and they are spaced only by 60 years. But the next iso-quadruplet will reappear only after 360 years (on 2404-4-5). Furthermore, a periodicity of 1800 years is needed to order to match both sexagenary cycle and the Gregorian cycle. For example, 4-3-18, 1980-3-18, and 3964-3-18 share the same four-pillar quadruplet.
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It received mixed reviews from the critics and was appreciated for its comic content. This is the second Indian movie after the 1990 Tamil movie Michael Madana Kama Rajan in which the lead role played a quadruplet.
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Quadruplets are much rarer than twins or triplets. As of 2007, there were approximately 3500 sets recorded worldwide. Quadruplet births are becoming increasingly common due to fertility treatments. There are around 70 sets of all-identical quadruplets worldwide.
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The solution to the iso-Gregorian quadruplet is a Diophantine problem. Suppose that the gap, g, between two successive four-pillar quadruplet is irregular and it is given by g = 60(365\lambda_1 + \lambda_2) and suppose that f and f + g' are two successive rata die numbers with identical Gregorian month and day, then it can be shown that the interval g' is given byg' = 365\lambda_3 + 366\lambda_4.For g and g' to coincide, we need solve 60(365\lambda_1 + \lambda_2) = 365\lambda_3 + 366\lambda_4, to which one of the solution is (\lambda_1, \lambda_2, \lambda_3, \lambda_4) = (33, 8, 1575, 402).
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Larry Lemmingberg, Louie Lemmingberg, Leonard Lemmingberg, and Liniment Lemmingberg are quadruplet brothers that are teal- colored and black-eyed lemmings. A Cartoon Network press kit gives the brothers the names Larry, Louie, Leonard, and Liniment. All four of their voices are done by Steve Little.
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A prime quadruplet (sometimes called prime quadruple) is a set of four primes of the form {p, p+2, p+6, p+8}. Retrieved on 2007-06-15. This represents the closest possible grouping of four primes larger than 3, and is the only prime constellation of length 4.
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An arbelos is formed from three collinear points A, B, and C, by the three semicircles with diameters AB, AC, and BC. Let the two smaller circles have radii r1 and r2, from which it follows that the larger semicircle has radius r = r1+r2. Let the points D and E be the center and midpoint, respectively, of the semicircle with the radius r1. Let H be the midpoint of line AC. Then two of the four quadruplet circles are tangent to line HE at the point E, and are also tangent to the outer semicircle. The other two quadruplet circles are formed in a symmetric way from the semicircle with radius r2.
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The first eight prime quadruplets are: {5, 7, 11, 13}, {11, 13, 17, 19}, {101, 103, 107, 109}, {191, 193, 197, 199}, {821, 823, 827, 829}, {1481, 1483, 1487, 1489}, {1871, 1873, 1877, 1879}, {2081, 2083, 2087, 2089} All prime quadruplets except {5, 7, 11, 13} are of the form {30n + 11, 30n + 13, 30n + 17, 30n + 19} for some integer n. (This structure is necessary to ensure that none of the four primes is divisible by 2, 3 or 5). A prime quadruplet of this form is also called a prime decade. A prime quadruplet contains two pairs of twin primes or can be described as having two overlapping prime triplets.
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Antonia Abraham (born 7 July 1997) is a Chilean rower. Together with quadruplet sister Melita, they have won several medals at age-group championships, including gold in the coxless pair at the 2017 World U23 Championships. She is also a 2015 Pan American Games silver medallist in the coxless pair.
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Less frequent are litters of quadruplet, quintuplet, and even sextuplet kids. Birthing, known as kidding, generally occurs uneventfully. Just before kidding, the doe will have a sunken area around the tail and hip, as well as heavy breathing. She may have a worried look, become restless and display great affection for her keeper.
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110 is a sphenic number and a pronic number. Following the prime quadruplet (101, 103, 107, 109), at 110, the Mertens function reaches a low of −5. 110 is the sum of three consecutive squares, 110 = 5^2 + 6^2 + 7^2. RSA-110 is one of the RSA numbers, large semiprimes that are part of the RSA Factoring Challenge.
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The twins were reunited at age twenty-eight. The book also includes research on twins reared apart and information on several other switched at birth twin cases. Segal is also the author of Indivisible by Two: Lives of Extraordinary Twins (Harvard University Press). This collection of essays on twelve twin, triplet and quadruplet sets brings together humanity and science in a unique way.
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Shearmur was born a quadruplet to Martin and Rhoda Brecker, and grew up in a traditional Jewish household. She married film composer Edward Shearmur, with whom she had two children. In 2014, the Shearmurs had a house featured in House Beautiful. Allison Shearmur died of lung cancer on January 19, 2018 at Ronald Reagan UCLA Medical Center in Los Angeles.
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In the brain, the corpora quadrigemina (Latin for "quadruplet bodies") are the four colliculi—two inferior, two superior—located on the tectum of the dorsal aspect of the midbrain. They are respectively named the inferior and superior colliculus. The corpora quadrigemina are reflex centers involving vision and hearing. It consists of groups of nerve cells-grey matter scattered in white matter.
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Melita Abraham (born 7 July 1997) is a Chilean rower. Together with quadruplet sister Antonia, they have won several medals at age-group championships, including gold in the coxless pair at the 2017 World U23 Championships. She is also a 2015 Pan American Games silver medallist in the coxless pair and has competed in the lightweight double sculls event at the 2016 Summer Olympics.
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Some triplets (called clone triplets) are the same image repeated with slight alterations (for example toned to different colors, or mixed color and monochromatic photos) or, more rarely, seemingly identical images with minor, detailed changes. Triplets are usually framed together or, in galleries, mounted near each other on the wall. Triplets are very often used on postcards. When four photos or paints are together, it is called photography quadruplet.
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Alternative terms found occasionally are "artificial division" , "abnormal divisions" , "irregular rhythm" , and "irregular rhythmic groupings" . The term "polyrhythm" (or "polymeter"), sometimes incorrectly used of "tuplets", actually refers to the simultaneous use of opposing time signatures . Besides "triplet", the terms "duplet", "quadruplet", "quintuplet", "sextuplet", "septuplet", and "octuplet" are used frequently. The terms "nonuplet", "decuplet", "undecuplet", "dodecuplet", and "tredecuplet" had been suggested but up until 1925 had not caught on (, ).
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The two superior colliculi sit below the thalamus and surround the pineal gland in the mammalian midbrain. It comprises the dorsal aspect of the midbrain, posterior to the periaqueductal gray and immediately superior to the inferior colliculus. The inferior and superior colliculi are known collectively as the corpora quadrigemina (Latin, quadruplet bodies). The superior colliculi are larger than the inferior colliculi, though the inferior colliculi are more prominent.
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Subjective logic is an example of computational trust where uncertainty is inherently embedded in the calculation process and is visible at the output. It is not the only one, it is e.g. possible to use a similar quadruplet (trust, distrust, unknown, ignorance) to express the value of confidence,Ding, L., Zhou, L., and Finin, T. (2003) Trust Based Knowledge Outsourcing for Semantic Web Agents. 2003 IEEE / WIC Int. Conf.
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At the same time Nandini, now aware Nagavalli is Munna, narrates him the story. Dawoor's sister wanted to divide the property and kept the rich property with her and her husband and poor property for her husband's brother and his wife. But the poor couple found gold in a deceased Shiva temple. On hearing this, Dawoor's sister had blackmailed them to reveal the place of gold but they managed to escape with their quadruplet children.
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Four of a kind, also known as quads, is a hand that contains four cards of one rank and one card of another rank (the kicker), such as ("four of a kind, nines"). It ranks below a straight flush and above a full house. Each four of a kind is ranked first by the rank of its quadruplet, and then by the rank of its kicker. For example, ranks higher than , which ranks higher than .
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The Genain quadruplets (born in 1930) are a set of identical quadruplet sisters. All four developed schizophrenia, suggesting a large genetic component to the cause of the disease. The pseudonym Genain, used to protect the identity of the family, comes from the Greek, meaning dire (αἶνος) birth (γεν-). The sisters were given the pseudonyms Nora, Iris, Myra and Hester, to represent each of the four letters in NIMH, the acronym for the United States National Institute of Mental Health.
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If {p, p+2, p+6, p+8} is a prime quadruplet and p−4 or p+12 is also prime, then the five primes form a prime quintuplet which is the closest admissible constellation of five primes. The first few prime quintuplets with p+12 are: {5, 7, 11, 13, 17}, {11, 13, 17, 19, 23}, {101, 103, 107, 109, 113}, {1481, 1483, 1487, 1489, 1493}, {16061, 16063, 16067, 16069, 16073}, {19421, 19423, 19427, 19429, 19433}, {21011, 21013, 21017, 21019, 21023}, {22271, 22273, 22277, 22279, 22283}, {43781, 43783, 43787, 43789, 43793}, {55331, 55333, 55337, 55339, 55343} ... . The first prime quintuplets with p−4 are: {7, 11, 13, 17, 19}, {97, 101, 103, 107, 109}, {1867, 1871, 1873, 1877, 1879}, {3457, 3461, 3463, 3467, 3469}, {5647, 5651, 5653, 5657, 5659}, {15727, 15731, 15733, 15737, 15739}, {16057, 16061, 16063, 16067, 16069}, {19417, 19421, 19423, 19427, 19429}, {43777, 43781, 43783, 43787, 43789}, {79687, 79691, 79693, 79697, 79699}, {88807, 88811, 88813, 88817, 88819} ... . A prime quintuplet contains two close pairs of twin primes, a prime quadruplet, and three overlapping prime triplets.
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A vanity plate issued in Chiang Mai Province Since 2003, certain serial numbers in each series are made available for auction. These include single-digit numbers (1); twin (11), triplet (111) and quadruplet (1111) numbers, round thousands (1000); straight three-digit (123) and four-digit (1234) numbers; and pairs of two like numbers (1122, 1212, 1221). Such IDs are accompanied by vanity plates with a special background image customized for each province. The auction plates, also called Super Number (, , lit.
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The problem of periodicity of four pillars is a problem in calendrical arithmetics but most of fortune tellers are unable to handle the mathematics correctly. Hee for example, proposed that it takes 240 years for a given four-pillar quadruplet to repeat itself. In p. 22, Hee wrote, > . . . because of the numerous possible combinations, it takes 60 years for > the same set of year pillars to repeat itself (by comparison, as set of > month pillars repeats itself after just five years).
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Similarly to orthogonal tRNAs and aminoacyl tRNA synthetases (aaRSs), orthogonal ribosomes have been engineered to work in parallel to the natural ribosomes. Orthogonal ribosomes ideally use different mRNA transcripts than their natural counterparts and ultimately should draw on a separate pool of tRNA as well. This should alleviate some of the loss of fitness which currently still arises from techniques such as Amber codon suppression. Additionally, orthogonal ribosomes can be mutated and optimized for particular tasks, like the recognition of quadruplet codons.
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The delivery of the children was accomplished by Dr. Fred Klenner and a black nurse named Margaret Ware. The basement was considered the blacks only wing at the time. The hospital didn't have incubator so the babies were wrapped in cotton gauze blankets and were placed close by each other to gain warmth. Mary Louise, Mary Ann, Mary Alice, and Mary Catherine were the names of the quadruplet sisters, with Mary Catherine being the last one born and the most unexpected at birth.
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It is not known if there are infinitely many prime quadruplets. A proof that there are infinitely many would imply the twin prime conjecture, but it is consistent with current knowledge that there may be infinitely many pairs of twin primes and only finitely many prime quadruplets. The number of prime quadruplets with n digits in base 10 for n = 2, 3, 4, ... is 1, 3, 7, 27, 128, 733, 3869, 23620, 152141, 1028789, 7188960, 51672312, 381226246, 2873279651 . the largest known prime quadruplet has 10132 digits.
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The 20 mm weapons had always had weak development perspectives, often being reconfigured or redesigned just enough to allow the weapons to find use. Indeed, it came as a surprise when Rheinmetall introduced the 2 cm Flakvierling 38, which improved the weapon just enough to make it competitive once again. The term Vierling literally translates to "quadruplet" and refers to the four 20 mm autocannon constituting the design. The Flakvierling weapon consisted of quad-mounted 2 cm Flak 38 AA guns with collapsing seats, folding handles, and ammunition racks.
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Aled, Carys, Llio and Bryn Winter-Brown are the quadruplet children of Chesney Brown (Sam Aston) and Gemma Winter (Dolly-Rose Campbell). The concept of the characters was announced in May 2019. A show spokesperson told Inside Soap that the quadruplets' introduction would spark the exposure of "a more vulnerable side to Gemma", adding, "Typically, Gemma and Chesney have very different ideas on parenting, so how will the pair cope with the new four arrivals?" The following month, it was confirmed that eight babies would be cast to portray the quadruplets.
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In compound meter, even-numbered tuplets can indicate that a note value is changed in relation to the dotted version of the next higher note value. Thus, two duplet eighth notes (most often used in meter) take the time normally totaled by three eighth notes, equal to a dotted quarter note. Four quadruplet (or quartole) eighth notes would also equal a dotted quarter note. The duplet eighth note is thus exactly the same duration as a dotted eighth note, but the duplet notation is far more common in compound meters .
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Meanwhile, Geralt does his best to track Rience and his mysterious employer. With the help of Dandelion, the novice priestess Shani, and the sorceress Philippa Eilhart, he forces a confrontation with Rience (the latter aided by the famous Michelet brothers, quadruplet assassins for hire), during which both are injured. Rience's master intervenes again, opening a portal for him, and Geralt is prevented from pursuing the mage by Eilhart, who also kills the last surviving Michelet brother so as to keep Geralt from learning the mysterious mage's identity. Geralt is left gravely wounded.
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In the United States in 1996 embryologist Jacques Cohen and others at the Institute for Reproductive Medicine and Science, Saint Barnabas Medical Center in Livingston, New Jersey first used cytoplasmic transfer in a human assisted reproduction procedure.Kim Tingley for the New York Times. June 27, 2014 The Brave New World of Three-Parent I.V.F. In 1997 the first baby was born using this procedure (Emma Ott). In 2001, Cohen and others reported that 10 single babies, twins, and a quadruplet at his New Jersey clinic and a further six children in Israel had been born using his technique.
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The show was produced by the legendary studios of Hanna- Barbera, which tried to retain the style of the original Thimble Theatre comic strip while complying with the prevailing content restrictions on violence. Featured characters, aside from the popular main stars of Popeye, Bluto, Olive Oyl and Wimpy, were Swee'Pea, Poopdeck Pappy, Eugene the Jeep and Popeye's quadruplet nephews. Popeye's outfit reverted to his sailor's uniform, except for his cap, which was retained as the white Navy hat. Bluto's name was restored, as it had erroneously been changed to "Brutus" for the early 1960s Popeye cartoons.
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It has received a triple-platinum certification by the Recording Industry Association of America (RIAA), which denotes track-equivalent sales of three million units based on sales and streams. In the United Kingdom, the single peaked at number 72 on the UK Singles Chart, and has received a platinum certification from the British Phonographic Industry (BPI), which denotes track-equivalent sales of 600,000 units. It was also successful in Australia, peaking at number 58 on the ARIA Charts. It has also received the highest certification in Australia, being awarded a quadruplet certification by the Australian Recording Industry Association (ARIA).
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Throughout the 1800s demographics registers were becoming more common in Europe, which generated data sets in different administrative regions. There was interest in twin research, and many demographers began studying patterns in birth rates. Analysis by Veit in 1855 of a Prussian data set covering 1826 to 1849 showed the numbers of twin, triplet, and quadruplet maternities were respectively one for every 89, 7910, and 371126 single maternities. Paul Strassmann analyzed the same data in 1889 and noted the rates of twin and triplet maternities were approximately one per 89 and 892, and in 1895 Hellin gave the law a general form.
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The Lund University Male Voice Choir, wearing white student caps, singing on the stairs of the Lund University main building on the first of May 2005. Students of Chalmers University of Technology in Gothenburg, Sweden, riding a penny-farthing and a quadruplet bicycle with student caps, during the Chalmers Cortège of 2006. The Swedish student cap (studentmössa), used since the mid-19th century by high school (Gymnasium) graduates, normally has a white crown, a black (or dark blue) band, and a black peak. At the front of the band is a cockade of blue and yellow, the colours of the Swedish flag.
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Ysbyty Cynfyn is a hamlet in the community of Blaenrheidol, Ceredigion, Wales, which is 69.1 miles (111.3 km) from Cardiff and 169.3 miles (272.4 km) from London. Ysbyty Cynfyn is represented in the National Assembly for Wales by Elin Jones (Plaid Cymru) and the Member of Parliament is Ben Lake (Plaid Cymru)National Assembly for Wales Website; recalled 24 February 2014parliament.uk Website; recalled 24 February 2014 The Parish Church of St John the Baptist was built in the early 19th century, replacing a previous one. The oldest gravestone dates from 1793 and first recorded quadruplet babies were buried in the churchyard in 1856.
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Students of Chalmers University of Technology in Gothenburg, Sweden, riding a penny- farthing and a quadruplet bicycle (in the background) with student caps, during the Chalmers Cortège of 2006. Before the first Cortège was arranged, students at Chalmers walked the streets with one foot on the pavement and one foot in the gutter each year on 30 April, the day when Chalmers students traditionally exchange their black student caps for white caps. In 1909, the students decided to gather all the horse carriages in the city to travel the distance they usually walked. The next year, the Chalmers Students' Union decided to organize a parade of student culture jokes.
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At the same time, Eilish broke the record for the most simultaneous Hot 100 entries for a female artist. "Lovely" received a double-platinum certification by the Recording Industry Association of America (RIAA), which denotes track- equivalent sales of two million units based on sales and streams. In the United Kingdom, the single peaked at number 47 on the UK Singles Chart—Eilish's first song to chart in the UK.. It received a platinum certification from the British Phonographic Industry (BPI), which denotes track-equivalent sales of 600,000 units. "Lovely" peaked at number 46 on the Canadian Hot 100 and received quadruplet platinum certification by Music Canada (MC).
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A triplex target DNA site (TTS), a stretch of DNA that is composed of polypurines, is able to form a triple-helix (triplex) structure in genomic DNA. Integrative WEB tools for identification and analysis of the triplex formation target DNA sequences, including PPRH sequences, associated with genes and regulatory elements (e.g., transcription factor binding sites, repeats, G-quadruplet motifs, SNPs, and non-protein coding regulatory DNA elements) in the human genome are publicly available (see External links). These tools could be used to search biologically meaningful genome polypurine stretches, help to understand biological roles of the natural paired polypurine domains like PPRH and to optimize experimental design of anti-gene treatment.
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Therefore, the β-keto thioester is formed out of the alcohol by a quadruplet of reactions with respectively N,N′-dicyclohexylcarbodiimide (DCC), N-chlorosuccinimide (NCS), sodium chlorite and 1,1'-carbonyldiimidazole (CDI). With 2,3-dichloro-5,6-dicyano-1,4-benzoquinone (DDQ) treatment, this β-keto thioester can be converted into an unstable diol, which is the acyclic precursor of the end product. In order to introduce the ring system that characterizes debromoaplysiotoxin in this molecule, hemiketal formation must be achieved between the C.7 ketone and the C.11 hydroxygroup, after which lactone formation can seal the deal. This can be achieved by a method called macrolactonization.
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It is conjectured that such examples exist for all primes k. , the largest prime for which this is confirmed is k = 19, for this AP-19 found by Wojciech Iżykowski in 2013: :19 + 4244193265542951705·17#·n, for n = 0 to 18. It follows from widely believed conjectures, such as Dickson's conjecture and some variants of the prime k-tuple conjecture, that if p > 2 is the smallest prime not dividing a, then there are infinitely many AP-(p−1) with common difference a. For example, 5 is the smallest prime not dividing 6, so there is expected to be infinitely many AP-4 with common difference 6, which is called a sexy prime quadruplet.
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St Helens won this epic 12–6, and the kit has since become synonymous with the club. Mick Sullivan joined Saints for £11,000, then a record transfer fee. They won the Lancashire Cup in the 1961–62 season, with a 25–9 success over Swinton (at Central Park, Wigan) seeing yet more silverware come St Helens' way under the management of Prescott. After his departure in 1962, Stan McCormick led the club to retaining the Lancashire Cup in his first year, again beating Swinton; and St Helens made it a quadruplet of Lancashire Cup successes with wins against Leigh in 1964, and once more Swinton in 1965, the latter success under coach Joe Coan.
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When the dimer binds to this region, the replicases cleave the loop region of the stem-loop and remain covalently bound to the H1 and H2 regions of the DNA, which becomes the 5' end of the DNA. The newly formed 3'OH end forms a primer using host RNA polymerase, which is then used by the host's DNA polymerase to begin transcription of the viral DNA via rolling circle replication. After the complementary DNA strand has been created, the stem region of the stem-loop forms a loose, non-hydrogen bonded, quadruplet DNA structure. This loosely associated structure can form short lived DNA-trimers which forms two templates for replication, as well as maintaining the nucleic integrity of the stem region of the stem-loop.
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In 2013, however, Farren Isaacs and George Church at Harvard University reported the replacement of all 321 TAG stop codons present in the genome of E. coli with synonymous TAA codons, thereby demonstrating that massive substitutions can be combined into higher-order strains without lethal effects. Following the success of this genome wide codon replacement, the authors continued and achieved the reprogramming of 13 codons throughout the genome, directly affecting 42 essential genes. An even more radical change in the genetic code is the change of a triplet codon to a quadruplet and even pentaplet codon pioneered by Sisido in cell-free systems and by Schultz in bacteria. Finally, non-natural base pairs can be used to introduce novel amino acid in proteins.
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105 is a triangular number, a dodecagonal number and the first Zeisel number. It is a sphenic number, and is the product of three consecutive prime numbers. 105 is the double factorial of 7. It is also the sum of the first five square pyramidal numbers. 105 comes in the middle of the prime quadruplet (101, 103, 107, 109). The only other such odd numbers less than a thousand are 9, 15, 195 and 825. 105 is also a pseudoprime to the prime bases 13, 29, 41, 43, 71, 83 and 97. The distinct prime factors of 105 add up to 15, and so do those of 104, hence the two numbers form a Ruth-Aaron pair under the first definition.
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In some of the aminoacyl tRNA synthetases, the cavity that holds the amino acid can be mutated and modified to carry unnatural amino acids synthesized in the lab, and to attach them to specific tRNAs. This expands the genetic code, beyond the twenty canonical amino acids found in nature, to include an unnatural amino acid as well. The unnatural amino acid is coded by a nonsense (TAG, TGA, TAA) triplet, a quadruplet codon, or in some cases a redundant rare codon. The organism that expresses the mutant synthetase can then be genetically programmed to incorporate the unnatural amino acid into any desired position in any protein of interest, allowing biochemists or structural biologists to probe or change the protein's function.
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Judging by the differing reactions of the various Juizes, the AIs appear to be independent entities, but initialized from the same generative code base. In episode 10, a woman appears at ATO headquarters with the same voice and manner of speech as Juiz; this serves to cast doubt on whether she is actually Juiz or whether her voice and personality (if not her memories) simply were used as the model for developing Juiz. In the Paradise Lost movie, the woman is revealed to be one of Mr. Outside's four quadruplet granddaughters: women who facilitate the requests that are given to the Juiz units. Seleção No. 7 is never seen in the series or films, but Seleção No. 8, a middle-aged man, makes a cameo at the conclusion of the second film during Mr. Outside's closing statement.
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If both p−4 and p+12 are prime then it becomes a prime sextuplet. The first few: {7, 11, 13, 17, 19, 23}, {97, 101, 103, 107, 109, 113}, {16057, 16061, 16063, 16067, 16069, 16073}, {19417, 19421, 19423, 19427, 19429, 19433}, {43777, 43781, 43783, 43787, 43789, 43793} Some sources also call {5, 7, 11, 13, 17, 19} a prime sextuplet. Our definition, all cases of primes {p-4, p, p+2, p+6, p+8, p+12}, follows from defining a prime sextuplet as the closest admissible constellation of six primes. A prime sextuplet contains two close pairs of twin primes, a prime quadruplet, four overlapping prime triplets, and two overlapping prime quintuplets. All prime sextuplets except {7, 11, 13, 17, 19, 23} are of the form {210n + 97, 210n + 101, 210n + 103, 210n + 107, 210n + 109, 210n + 113} for some integer n.
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Trace of modeled oxytocin-sensitive neuron showing bursts Bursting, or burst firing, is an extremely diverse general phenomenon of the activation patterns of neurons in the central nervous system and spinal cord where periods of rapid action potential spiking are followed by quiescent periods much longer than typical inter-spike intervals. Bursting is thought to be important in the operation of robust central pattern generators, the transmission of neural codes, and some neuropathologies such as epilepsy. The study of bursting both directly and in how it takes part in other neural phenomena has been very popular since the beginnings of cellular neuroscience and is closely tied to the fields of neural synchronization, neural coding, plasticity, and attention. Observed bursts are named by the number of discrete action potentials they are composed of: a doublet is a two-spike burst, a triplet three and a quadruplet four.
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