But Pakistani officials went to pains to say the toll was unselective, with Muslims and Christians among the dead and bereaved.
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Brosens and Quenby's research has found that in women with recurrent miscarriage, the womb lining is often super-receptive but unselective, meaning that it allows genetically doomed embryos to implant and grow.
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The unselective collecting policy has created a lasting bond between museum and community.
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Scolecida is an infraclass of polychaete worms. Scolecids are mostly unselective deposit feeders on marine detritus.
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Under EDDS deficiency, initial unselective extraction of heavy metals was observed, followed by heavy metal exchange and re-adsorption of heavy metals that have lower stability constant with EDDS.
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In the converse reaction, carbanionic reagents react with elemental sulfur to afford mixtures of the thioether, disulfide, and higher polysulfides. These reactions are often unselective but can be optimized for specific applications.
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In May 2018, the school announced plans to create a primary school, linked to the secondary school being built on the current Podsmead site. The new primary school would, unlike main school, be unselective and would be a free school.
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Purple pitchers have been investigated as a biocontrol for the Asian Hornet Vespa velutina in Europe \- they are natural bottle traps and were already found catching a few. However Sarracenia purpurea has been judged too unselective to use after closer study.
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For laboratory use, the N-alkylation reaction is often unselective. A variety of alternative methods have been developed, such as the Delépine reaction, which uses hexamine. The Gabriel synthesis, involving the use of an equivalent to NH2−, only applies to primary alkyl halides.
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Unselective in action, it kills potato beetles, cucumber beetles, flea beetles, cabbage worms, raspberry beetles, and asparagus beetles, as well as most other arthropods. It biodegrades rapidly in soil, with 90% degraded after 1–3 months at and three times faster at .
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Orbiniidae is a family of polychaete worms. Orbiniids are mostly unselective deposit feeders on marine detritus. They can be found from the neritic zone to abyssal depths.Orbiniidae polychaetes (Polychaeta: Scolecida) from Coiba Island, eastern Pacific of Panama, with description of a new species The family was revised in 1957 by Hartman Hartman, O. 1957.
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Biocontrol of Vespa velutina has been attempted using Sarracenia purpurea - the purple pitcher plant. Pitcher plants are natural bottle traps. Both of these are invasives in France and pitchers were found to be naturally catching hornets, and so were investigated as a biocontrol. However Sarracenia purpurea has been judged too unselective to use after closer study.
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Smooth newts, including the larvae, are unselective carnivores, feeding mainly on diverse invertebrates such as earthworms, snails or insects, or smaller plankton. Cannibalism also occurs, mainly by preying on eggs of its own species. Various predators eat smooth newts, including waterbirds, snakes and frogs, but also larger newts such as the northern crested newt (Triturus cristatus).
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The hydroxylation process involves conversion of a CH group into a COH group. Hydroxylation is an oxidative process. The oxygen that is inserted into the C-H bond is usually derived from atmospheric oxygen (O2). Since O2 itself is a slow and unselective hydroxylating agent, catalysts are required to accelerate the pace of the process and to introduce selectivity.
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AM-2232 (1-(4-cyanobutyl)-3-(naphthalen-1-oyl)indole) is a drug that acts as a potent but unselective agonist for the cannabinoid receptors, with a Ki of 0.28 nM at CB1 and 1.48 nM at CB2. In the United States, all CB1 receptor agonists of the 3-(1-naphthoyl)indole class such as AM-2232 are Schedule I Controlled Substances.
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Streit, B. (1977): Morphometric relationships and feeding habits of two species of Chaetogaster, Ch. limnaei and Ch. diastrophus (Oligochaeta). Arch. Hydrobiol./Supp. 48: 424-437. In principle, all species are therefore omnivores, the bigger species taking in mainly animal food and the smaller ones rather plant particles. The unselective nature of their feeding is clearly shown by the fact that sand grains and other indigestible particles (e.g.
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Monoamines are connected to the pathophysiology of depression. Symptoms may occur because concentrations of neurotransmitters, such as norepinephrine and serotonin, are insufficient, leading to downstream changes. Medications for depression affect the transmission of serotonin, norepinephrine, and dopamine. Older and more unselective antidepressants like TCAs and MAOIs inhibit the reuptake or metabolism of norepinephrine and serotonin in the brain, which results in higher concentrations of neurotransmitters.
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"Lincoln, an ordinary, unselective New York City high school, is proud of a galaxy of prominent alumni, who include the playwright Arthur Miller, Representative Elizabeth Holtzman, the authors Joseph Heller and Ken Auletta, the producer Mel Brooks, the singer Neil Diamond and the songwriter Neil Sedaka." and was a member of the fencing team.Wild, David. "Neil Diamond Interview", Rolling Stone, March 24, 1988, pp. 102–09.
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As a result, quazepam has little or no muscle relaxant properties. Most other benzodiazepines are unselective and bind to type1 GABAA receptors and type2 GABAA receptors. Type1 GABAA receptors include the α1 subunit containing GABAA receptors which are responsible for hypnotic properties of the drug. Type 2 receptors include the α2, α3 and α5 subunits which are responsible for anxiolytic action, amnesia and muscle relaxant properties.
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Fossilized dung associated with late Cretaceous titanosaurids has revealed phytoliths, silicified plant fragments, that offer clues to a broad, unselective plant diet. Besides the plant remains that might have been expected, such as cycads and conifers, discoveries published in 2005 revealed an unexpectedly wide range of monocotyledons, including palms and grasses (Poaceae), including ancestors of rice and bamboo, which has given rise to speculation that herbivorous dinosaurs and grasses co-evolved.
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Accessed September 20, 2009. "Lincoln, an ordinary, unselective New York City high school, is proud of a galaxy of prominent alumni, who include the playwright Arthur Miller, Representative Elizabeth Holtzman, the authors Joseph Heller and Ken Auletta, the producer Mel Brooks, the singer Neil Diamond and the songwriter Neil Sedaka." Holtzman graduated from Radcliffe College of Harvard University (magna cum laude, Phi Beta Kappa, 1962), and Harvard Law School (1965).
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In the presence of acid catalysts, ethylene oxide dimerizes to afford dioxane: : Synthesis of dioxane The reaction mechanism is as follows: : Mechanism of dimerization The dimerization reaction is unselective. By-products include acetaldehyde (due to isomerization). The selectivity and speed of dimerization can be increased by adding a catalyst, such as platinum, platinum-palladium, or iodine with sulfolane. 2-methyl-1,3-dioxolane is formed as a side product in the last case.
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The Court concluded that the Fourteenth Amendment's guarantee of intimate association does not apply to the Jaycees because they are not a sufficiently intimate group.468 U.S. at 620. The Court held that this guarantee - which protects, among other things, the right to marriage, childbirth, and cohabitation with one's relatives - does not extend to the Jaycees because local chapters of the Jaycees are "large and basically unselective groups."468 U.S. at 620-21.
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He said of the creation of Beamish Museum: "It is essential that collecting be carried out quickly and on as big a scale as possible. It is now almost too late." To this end, Atkinson initiated a policy of "unselective collecting", saying: "you offer it to us and we will collect it". This method of building up the collection proved highly successful and in addition forged links between the institution and the surrounding community.
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By-catching is an inevitable aspect of fishing where unwanted fish or other marine organisms including turtles, dolphins and juveniles are caught. This is a by-product of the unselective nature of modern fishing gear, such as bottom trawling which captures everything in the path of the net. Consumer-grade gear such as fishing rods and nets are used by pirate fishers to undertake illegal, unreported and unregulated fishing which adds to the number of marine species taken from their ecosystems.
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Following literary theorists, who examined the role of telling and showing in narration, Roy Schafer makes a distinction between telling and showing in the psychoanalytical situation. Telling happens when the analysand tells in words about events; about the past. Showing happens when the analysand conveys ideas, feelings, fantasies or reactions, verbal or non- verbal and freely associates these in an unselective way and without rehearsal. The analysand seems to be operating in the present; even when talking about the past.
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Bondfield, p. 10 The book had an indifferent reception; in The Observer, Harold Nicolson described it as "ill composed and badly proportioned", with too much space devoted to inconsequential meetings while truly important events were hurried over. Nevertheless, he thought the book provided "a fine example of resolute and in the end triumphant energy". The Manchester Guardians reviewer also criticised the work's confused structure and unselective detail, but found it "a useful, direct and honest" account of Labour's early years.
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It contains enough of the toxic rotenoids rotenone and deguelin to be used as an insecticide and piscicide. As these are naturally occurring compounds, they were formerly used in organic farming. Since it is highly unselective and kills useful, as well as pest, animals, it is considered harmful to the environment today. Also, chronic exposure to rotenone and deguelin seems to increase the risk of Parkinson's disease even in mammals, for which these compounds are less acutely toxic than for fish and insects.
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Chaperone-assisted selective autophagy is a cellular process for the selective, ubiquitin-dependent degradation of chaperone-bound proteins in lysosomes. Autophagy (Greek: ‘self-eating’) was initially identified as a catabolic process for the unselective degradation of cellular content in lysosomes under starvation conditions. However, autophagy also comprises selective degradation pathways, which depend on ubiquitin conjugation to initiate sorting to lysosomes. In the case of chaperone-assisted selective autophagy, dysfunctional, nonnative proteins are recognized by molecular chaperones and become ubiquitinated by chaperone-associated ubiquitin ligases.
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Some exhibit hyperactivity and attention problems as well as difficulties in peer relationships. In the only longitudinal study that has followed children with indiscriminate behavior into adolescence, these children were significantly more likely to exhibit poor peer relationships. Studies of children who were reared in institutions have suggested that they are inattentive and overactive, no matter what quality of care they received. In one investigation, some institution-reared boys were reported to be inattentive, overactive, and markedly unselective in their social relationships, while girls, foster-reared children, and some institution-reared children were not.
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Sedaka attended Abraham Lincoln High School in Brooklyn, from which he graduated in 1956.Hechinger, Fred M. "ABOUT EDUCATION; Personal Touch Helps", The New York Times, January 1, 1980; accessed September 20, 2009. "Lincoln, an ordinary, unselective New York City high school, is proud of a galaxy of prominent alumni, who include the playwright Arthur Miller, Representative Elizabeth Holtzman, the authors Joseph Heller and Ken Auletta, the producer Mel Brooks, the singer Neil Diamond and the songwriter Neil Sedaka." He and his wife Leba (née Strassberg) have been married since 1962.
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Curran is known for his pioneering work on organic radicals and radical cyclizations, especially directed towards organic synthesis. Prior to the 1980s, radicals were neglected because they were thought to be too reactive and too unselective for use in organic synthesis. Curran parlayed cascade reactions of radicals (also called tandem reactions or domino reactions) into powerful tools to make natural products. His 1985 total synthesis of hirsutene,Curran, D. P.; Rakiewicz, D. M., “Tandem radical approach to linear condensed cyclopentanoids. Total synthesis of hirsutene” J. Am. Chem. Soc.
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The therapeutic pharmacological properties of zopiclone include hypnotic, anxiolytic, anticonvulsant, and myorelaxant properties. Zopiclone and benzodiazepines bind to the same sites on GABAA-containing receptors, causing an enhancement of the actions of GABA to produce the therapeutic and adverse effects of zopiclone. The metabolite of zopiclone called desmethylzopiclone is also pharmacologically active, although it has predominately anxiolytic properties. One study found some slight selectivity for zopiclone on α1 and α5 subunits, although it is regarded as being unselective in its binding to α1, α2, α3, and α5 GABAA benzodiazepine receptor complexes.
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Rinconsaurus, like all sauropods, was an herbivore. Fossilized dung associated with late Cretaceous titanosaurids has revealed phytoliths, silicified plant fragments, that offer clues to a broad, unselective plant diet. Besides the plant remains that might have been expected, such as cycads and conifers, discoveries published in 2005 revealed an unexpectedly wide range of monocotyledons, including palms and grasses (Poaceae), including ancestors of rice and bamboo, which has given rise to speculation that herbivorous dinosaurs and grasses co-evolved. Titanosaurid teeth are usually spatulate (spoon-shaped) or shaped like pegs.
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Like other alkanes, pentanes are largely unreactive at standard room temperature and conditions - however, with sufficient activation energy (e.g., an open flame), they readily oxidize to form carbon dioxide and water: :C5H12 \+ 8 O2 → 5 CO2 \+ 6 H2O + heat/energy Like other alkanes, pentanes undergo free radical chlorination: :C5H12 \+ Cl2 → C5H11Cl + HCl Such reactions are unselective; with n-pentane, the result is a mixture of the 1-, 2-, and 3-chloropentanes, as well as more highly chlorinated derivatives. Other radical halogenations can also occur. Pentane is a component of exhaled breath for some individuals.
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" Writing for The New York Times, critic Vincent Canby called the film "unbearably long", and concluded of the three characters that "when it's all over, they are tired, but not much wiser—which is pretty much the sum and substance of Husbands." Tony Mastroianni of the Cleveland Press wrote that the "[film's] dialog consists of fragments, of exclamations, of three actors trying to upstage each other. What has been done is undisciplined and what has been given us is unselective. The camera runs and simply photographs everything that passes before it.
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Reduction on palladium, promoted by ethanolamine, followed by acidic workup yielded the deprotected 1,2-aminoalcohol. The aminoalcohol was converted directly to the corresponding allyl-diamine in an interesting cascade sequence that commences with the unselective imination of benzaldehyde with azeotropic water removal in methyl tert-butyl ether. Mesylation, followed by removal of the solid byproduct triethylamine hydrochloride, results in an intermediate that was poised to undergo aziridination upon transimination with another equivalent of allylamine. With the librated methanesulfonic acid, the aziridine opens cleanly to yield a diamine that immediately undergoes a second transimination.
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Reviewing the literature on China's pre-Han history in his article Legends and Cults in Ancient China, he pointed out that "a common feature to most of these treatises is a curious lack of critical method in the handling of the material". In particular, Karlgren criticised the unselective use of documents from different ages when reconstructing China's ancient history. "In this way very full and detailed accounts have been arrived at—but accounts that are indeed caricatures of scientifically established ones." In 1950, Karlgren was inducted into the Royal Netherlands Academy of Arts and Sciences.
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Found to feed off the top millimeter of sediment by using a boring motion with the tip of its siphon into the sediment or by using a rotating motion similar to Scrobicularia plana. New sediment is found by moving the siphon into virgin sediment but the clams have also been observed to consume their pseudofeces and feces. It is assumed that the siphon tip is unselective in the particles it intakes. Non-specific nematodes have been found in the stomach in all stages of digestion from live to empty cuticles.
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The white-eared honeyeater's preferred habitat is in forests, woodlands, heathlands, mallee and dry inland scrublands. A eucalyptus canopy, rough bark and a shrub layer are the most important requirements for white-eared honeyeaters. The canopy can provide nectar in spring, the bark can provide insects year round, and the shrub layer is used for nesting and shelter. The white-eared honeyeater prefers mature vegetation with a dense understory.. They are relatively unselective regarding habitat, both floristically and structurally, as they can be found in many different forest and woodland types, and either edge or interior habitats.
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RTI-126 (RTI-4229-126 or (–)-2β-(1,2,4-oxadiazol-5-methyl)-3β-phenyltropane) is a phenyltropane derivative which acts as a potent monoamine reuptake inhibitor and stimulant drug, and has been sold as a designer drug. It is around 5 times more potent than cocaine at inhibiting monoamine reuptake in vitro, but is relatively unselective. It binds to all three monoamine transporters, although still with some selectivity for the dopamine transporter. RTI-126 has a fast onset of effects and short duration of action, and its pharmacological profile in animals is among the closest to cocaine itself out of all the drugs in the RTI series.
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In addition to reversibility, MAOIs differ by their selectivity of the MAO enzyme subtype. Some MAOIs inhibit both MAO-A and MAO-B equally, other MAOIs have been developed to target one over the other. MAO-A inhibition reduces the breakdown of primarily serotonin, norepinephrine, and dopamine; selective inhibition of MAO-A allows for tyramine to be metabolised via MAO-B. Agents that act on serotonin if taken with another serotonin-enhancing agent may result in a potentially fatal interaction called serotonin syndrome or with irreversible and unselective inhibitors (such as older MAOIs), of MAO a hypertensive crisis as a result of tyramine food interactions is particularly problematic with older MAOIs.
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Although trawling is a highly unselective fishing method, offshore fishing grounds are not generally very biodiverse (i.e. they are only inhabited by a few species) and the discard rate for this fishery is estimated to be 10% of the total catch. However, this fishing method is likely to have significant impacts on bottom habitats and concerns are expressed around the number of seabird mortalities caused during trawling (estimated at 8000 per year). The hake component of the offshore demersal trawl fishery has been certified by the Marine Stewardship Council since 2004, and the current management system for this fishery employs a number of ecosystem-based management measures which address issues such as bycatch, closed areas and benthic habitat impacts.
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An experiment by Biro and Post (2008) shows that despite being mechanically unselective of gill nets, behavioural variation in certain fish species can indeed affect the likelihood of them being caught and therefore be a function for selectivity. Using a ‘selection experiment in the field’ model, two genotypes of rainbow trouts (Oncorhynchus mykiss) were transplanted into identical artificial lake habitats and subjected to matching gill net fishing pressures. The net in question were designed to capture all size variability within the simulated populations. Trouts exhibiting the genotypes for faster growth rates and therefore a more active lifestyle were found to have a 60% increase chance to be caught in comparison to those characterised by the more sedentary genotype.
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The primary difference between the Fischer-Tropsch process and methanol to gasoline processes such as STG+ are the catalysts used, product types and economics. Generally, the Fischer-Tropsch process favors unselective cobalt and iron catalysts, while methanol to gasoline technologies favor molecular size- and shape-selective zeolites.Eduardo Falabella Sousa-Aguiar, Fabio Bellot Noronha, and Arnaldo Faro, Jr. "The Main Catalytic Challenges in GTL (Gas-to-Liquids) Processes" in Catalysis Science & Technology, 2011, RSC. In terms of product types, Fischer-Tropsch production has been limited to linear paraffins, such as synthetic crude oil, whereas methanol to gasoline processes can produce aromatics, such as xylene and toluene, and naphthenes and iso- paraffins, such as drop-in gasoline and jet fuel.
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A number of TRPV4 agonists and antagonists have been identified since its discovery. The discovery of unselective modulators (e.g. antagonist Ruthenium red) was followed by the apparition of more potent (agonist 4aPDD) or selective (antagonist RN-1734) compounds, including some with bioavailability suitable for in vivo pharmacology studies such as agonist GSK1016790A (with ~10 fold selectivity vs TRPV1), and antagonists HC-067047 (with ~5 fold selectivity vs hERG and ~10 fold selectivity vs TRPM8) and RN-9893 (with ~50 fold selectivity vs TRPM8 and ~10 fold selectivity vs M1). Resolvin D1 (RvD1), a metabolite of the omega 3 fatty acid, docosahexaenoic acid, is a member of the specialized proresolving mediators (SPMs) class of metabolites that function to resolve diverse inflammatory reactions and diseases in animal models and, it is proposed, humans.
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He stated the new museum should "attempt to make the history of the region live" and illustrate the way of life of ordinary people. He hoped the museum would be run by, be about and exist for the local populace, desiring them to see the museum as theirs, featuring items collected from them.p. 116-119, The Essential Guide to Beamish, 2014, Beamish Museum Fearing it was now almost too late, Atkinson adopted a policy of "unselective collecting" -- "you offer it to us and we will collect it." Donations ranged in size from small items to locomotives and shops, and Atkinson initially took advantage of a surplus of space available in the 19th- century French chateau-style building housing the Bowes Museum to store items donated for the open air museum.
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Most of the older antipsychotic drugs such as chlorpromazine and haloperidol are antagonists for the dopamine D2 receptor, but are, in general, very unselective, at best selective only for the "D2-like family" receptors and so binding to D2, D3 and D4, and often also to many other receptors such as those for serotonin and histamine, resulting in a range of side-effects and making them poor agents for scientific research. In similar manner, older dopamine agonists used for Parkinson's disease such as bromocriptine and cabergoline are poorly selective for one dopamine receptor over another, and, although most of these agents do act as D2 agonists, they affect other subtypes as well. Several selective D2 ligands are, however, now available, and this number is likely to increase as further research progresses.
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Another key function of the glymphatic system was documented by Thrane et al., who, in 2013, demonstrated that the brain's system of paravascular pathways plays an important role in transporting small lipophilic molecules. Led by M. Nedergaard, Thrane and colleagues also showed that the paravascular transport of lipids through the glymphatic pathway activated glial calcium signalling and that the depressurization of the cranial cavity, and thus impairment of the glymphatic circulation, led to unselective lipid diffusion, intracellular lipid accumulation, and pathological signalling among astrocytes. Although further experiments are needed to parse out the physiological significance of the connection between the glymphatic circulation, calcium signalling, and paravascular lipid transport in the brain, the findings point to the adoption of a function in the CNS similar to the capacity of the intestinal lymph vessels (lacteals) to carry lipids to the liver.
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"Lincoln, an ordinary, unselective New York City high school, is proud of a galaxy of prominent alumni, who include the playwright Arthur Miller, Representative Elizabeth Holtzman, the authors Joseph Heller and Ken Auletta, the producer Mel Brooks, the singer Neil Diamond and the songwriter Neil Sedaka." After graduation (circa 1936), he began to work as a psychiatric aide and also a copywriter before accepting faculty posts at New York University and University of New Hampshire. On May 1, 1935, Miller joined the League of American Writers (1935–1943), whose members included Alexander Trachtenberg of International Publishers, Franklin Folsom, Louis Untermeyer, I. F. Stone, Myra Page, Millen Brand, Lillian Hellman, and Dashiell Hammett. (Members were largely either Communist Party members or fellow travelers.) At the University of Michigan, Miller first majored in journalism and worked for the student newspaper, The Michigan Daily, as well as the satirical Gargoyle Humor Magazine.
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S-40503 is an investigational selective androgen receptor modulator (SARM) developed by the Japanese company Kaken Pharmaceuticals, which was developed for the treatment of osteoporosis. SARMs are a new class of drugs which produce tissue-specific anabolic effects in some tissues such as muscle and bone, but without stimulating androgen receptors in other tissues such as in the prostate gland, thus avoiding side effects such as benign prostatic hypertrophy which can occur following treatment with unselective androgens like testosterone or anabolic steroids. S-40503 is a SARM that shows good functional selectivity for bone tissue, and has relatively little effect on muscle mass and no observable effect on the prostate gland. In animal studies it was shown to increase both bone mineral density and biomechanical strength of femoral cortical bone, and at low doses showed anabolic effects only on bone tissue, while at higher doses both bone and muscle growth were affected, yet prostate gland enlargement was not seen at any dose tested.
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