But it certainly desensitizes and in some cases encourages violence in society.
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"The nature of volatility is that it desensitizes over time," he said.
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"It slowly desensitizes the child over time," Kevin Trapp, DBV's chief commercial officer, told CNBC.
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This kind of broad-brush race-baiting desensitizes us to the real racists out there.
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But the repetitive, easy banality of the story is precisely the point: It desensitizes us.
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Research does show that exposure to frequent use of hate speech desensitizes people and can increase prejudice.
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His take is that the approach doesn't heal the person but rather dulls and desensitizes them from the experience.
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It has long been speculated that enacting violence in a virtual world desensitizes people to violence in the real one.
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The controller stereotype is probably the most limiting, because it desensitizes us to the influence of our surroundings over us.
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"I mean, you're going so hard during the campaign that it sort of desensitizes you to virtually any emotion, if that makes any sense," Trump Jr. added.
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Perhaps living in such a landscape desensitizes one to pleasure; you could speculate as to whether he's depicting this process or whether it's actually happened to him.
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The standard treatment for PTSD, a form of fear conditioning, is repeated exposure to the stimulus, which desensitizes people to the trigger, teaching them it is now safe.
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When this miniseries is all said and done, we may look back on it and realize that it was about all of the ways television desensitizes us to the world all along.
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"Habit weakens all things," Proust wrote, describing the ways in which time loosens our connection to what we felt in the past and desensitizes us to the world that takes its place.
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"We want to move reactions to incidents of police brutality away from sensationalized viral footage which has a transitory impact and desensitizes people to the problem," said Guilherme Pimentel, the project's coordinator.
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This was the finding of a study published in Nature Neuroscience, which showed that telling small lies desensitizes our brains to the associated negative emotions, which may encourage us to tell bigger lies in the future.
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But I think they did a video about how this type of language, and how it circulates around the nation desensitizes people, and things we would once consider absurd for politicians to say are now just normal.
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During a Colorado vaping focus group for teens, many young vapers said they had experienced vape tongue, a condition where vape juice desensitizes a person's tongue so they can't taste flavors, according to The Wall Street Journal.
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And the lack of public discussion about the lives affected not only dangerously desensitizes us to the cost of war, but it allows politicians to avoid their duty to debate and authorize the commander in chief's decision to wage it.
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As for the sensitivity issues, those are gradually lessened thanks to the inclusion of natural potassium nitrate, which desensitizes teeth by filling in those tiny tubules that expose dentin and connect the underlying nerves to the hot, cold, or pressure causing pain.
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Louie Swisher: And so now, you know, Trump promoting hate speech and promoting all these other things that he does that are not good, I guess, in the simplest terms, I guess are, it desensitizes us as a nation, and makes us gradually become okay with the things he says.
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Leptin desensitizes the brain to hunger signals and inhibits NPY-secreting neurons.
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The statistical distribution of the final levels is decided by a weighted average over a region of the range of the ADC. This in turn desensitizes it to the width of any specific level.
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Customers using websites with seals have higher rates of satisfaction and intention to purchase again. Privacy seals also desensitizes customers' perceptions of service performance. Kimery et. al found in their study that privacy seals only had a slightly positive impact on trust where unfamiliar e-commerce retailers were concerned.
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One characteristic of some Viola is the elusive scent of their flowers; along with terpenes, a major component of the scent is a ketone compound called ionone, which temporarily desensitizes the receptors of the nose, thus preventing any further scent being detected from the flower until the nerves recover.
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Another suggested explanation for the phenomenon is possible narcissistic feelings. Incest is extremely rare between people raised together in early childhood due to a reverse sexual imprinting known as the Westermarck effect, which desensitizes them to later close sexual attraction. It is hypothesized that this effect evolved to prevent inbreeding.
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It is possible that IFNL4 interferes with the antiviral activity of other interferons. There is evidence that IFNL4 desensitizes the response to IFN-α treatment in chronic hepatitis C through long-term induction of negative regulators of the interferon response and that IFNL4 acts faster than other type III IFNs in inducing such genes.
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It desensitizes to a small conductance in continuous light. Recovery from desensitization is accelerated by extracellular H+ and a negative membrane potential. It may be a photoreceptor for dark adapted cells. A transient increase in hydration of transmembrane α-helices with a t(1/2) = 60 μs tallies with the onset of cation permeation.
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Such rape myths include the belief that women really want to be raped and that they mean yes when they say no. Additionally, according to MacKinnon, pornography desensitizes viewers to violence against women, and this leads to a progressive need to see more violence in order to become sexually aroused, an effect she claims is well documented.
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In addition, it exhibits a finite input impedance and a non-zero output impedance. Although practical op-amps are not ideal, the model of an ideal op-amp often suffices to understand circuit operation at low enough frequencies. As discussed in the previous section, the feedback circuit stabilizes the closed-loop gain and desensitizes the output to fluctuations generated inside the amplifier itself.
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Zucapsaicin excites and desensitizes C-fibers via agonist at TRPV1 on nociceptive neurons. It binds to intracellular sites and initially stimulates the channels, causing burning sensation. The mechanism of pharmacological action of zucapsaicin has not been fully understood yet. It is suggested that this compound, similarly to its trans isomer, is an agonist of the vanilloid receptor VR1 (TRPV1) and a neuronal calcium channel blocker.
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Obesity has been contributing to increased insulin resistance due to the population's daily caloric intake rising. Insulin resistance increases hyperglycemia because the body becomes over saturated by glucose. Insulin resistance desensitizes insulin receptors, preventing insulin from lowering blood sugar levels. The leading cause of hyperglycemia in type 2 diabetes is the failure of insulin to suppress glucose production by glycolysis and gluconeogenesis due to insulin resistance.
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SIC can also be employed to reduce or eliminate adjacent channel interference. This allows a device containing two radios (such as a Wi-Fi access Point with two 5 GHz radios) to use any pair of channels regardless of separation. Adjacent channel interference consists of two main components. The signal on the transmit frequency, known as the blocker, may be so strong that it desensitizes a receiver listening on an adjacent channel.
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Martin Bristol, a young boy with congenital analgesia, is kidnapped by psychotic serial killer Graham Sutter. At an abandoned slaughterhouse once operated by his family, Graham cuts Martin's cheek before butchering a captive young woman in front of him. Martin attempts to escape, but Graham catches him and returns him to the slaughterhouse, where he continues to hold the boy and future female victims captive. Over the next five years, Graham brutally butchers several young women, forcing Martin to watch as the trauma slowly desensitizes him.
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Since the repeater is usually located at an elevation higher than the other radios using it, their range is greatly extended. 200px Because the transmitter and receiver are on at the same time, isolation must exist to keep the repeater's own transmitter from degrading the repeater receiver. If the repeater transmitter and receiver are not isolated well, the repeater's own transmitter desensitizes the repeater receiver. The problem is similar to being at a rock concert and not being able to hear the weak signal of a conversation over the much stronger signal of the band.
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Following depolarization, the acetylcholine molecules are then removed from the end plate region and enzymatically hydrolysed by acetylcholinesterase. Normal end plate function can be blocked by two mechanisms. Nondepolarizing agents, such as tubocurarine, block the agonist, acetylcholine, from binding to nicotinic receptors and activating them, thereby preventing depolarization. Alternatively, depolarizing agents, such as succinylcholine, are nicotinic receptor agonists which mimic Ach, block muscle contraction by depolarizing to such an extent that it desensitizes the receptor and it can no longer initiate an action potential and cause muscle contraction.
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Nitroglycerin can be added to nitrocellulose to form "double-base propellants". Nitrocellulose desensitizes nitroglycerin to prevent detonation in propellant-sized grains, (see dynamite), and the nitroglycerin gelatinises the nitrocellulose and increases the energy. Double-base powders burn faster than single-base powders of the same shape, though not as cleanly, and burn rate increases with nitroglycerin content. In artillery, Ballistite or Cordite has been used in the form of rods, tubes, slotted-tube, perforated-cylinder or multi-tubular; the geometry being chosen to provide the required burning characteristics.
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Similarly to nicotine, cotinine binds to, activates, and desensitizes neuronal nicotinic acetylcholine receptors, though at much lower potency in comparison. It has demonstrated nootropic and antipsychotic-like effects in animal models. Cotinine treatment has also been shown to reduce depression, anxiety, and fear-related behavior as well as memory impairment in animal models of depression, PTSD, and Alzheimer's disease. Nonetheless, treatment with cotinine in humans was reported to have no significant physiologic, subjective, or performance effects in one study, though others suggest that this may not be the case.
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After olfactory neurons depolarize in response to an odorant, the G-protein mediated second messenger response activates adenylyl cyclase, increasing cyclic AMP (cAMP) concentration inside a cell, which then opens a cyclic nucleotide gated cation channel. The influx of Ca2+ ions through this channel triggers olfactory adaptation immediately because Ca2+/calmodulin- dependent protein kinase II or CaMK activation directly represses the opening of cation channels, inactivates adenylyl cyclase, and activates the phosphodiesterase that cleaves cAMP. These series of actions by CaMK, desensitizes olfactory receptors to prolonged odorant exposure. An ORN or an Olfactory Receptor Neuron alert goes off to detect the smell.
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More vigorous studies are needed for all these suggestions, as well as common PTSD therapies that have not yet been thoroughly explored with the distinction of perpetration versus victimization in mind. Other proposed treatments have been proven to be ineffective. The “flooding” technique, technically called Prolonged Exposure, which desensitizes the sufferer of trauma by repeated exposure to reminders of it in controlled settings, appears to be a bad idea, counter-indicated when the trauma involved being active in inflicting harm.Pitman, R. K., Altman, B., Greenwald, E., Longpre, R. E., Macklin, M. L., Poire, R. E., & Steketee, G. S. (1991).
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Some research suggests that this chronic desensitization is due to the over activation of a kinase, G protein-coupled receptor kinase 2 (GRK2), which phosphorylates and deactivates certain G protein coupled receptors . When the G protein coupled receptor is activated, the Gβγ subunit recruits GRK2 which then phosphorylates and desensitizes GPCRs like the βAR. Preventing the interaction of the βγ subunit with GRK2 has therefore been studied as a potential target for increasing heart contractile function. The developed molecule GRK2ct is a protein inhibitor which inhibits the signalling properties of Gβγ subunit but does not interfere with alpha subunit signalling.
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MacKinnon argued that pornography leads to an increase in sexual violence against women through fostering rape myths. Such rape myths include the belief that women really want to be raped and that they mean yes when they say no. She held that "rape myths perpetuate sexual violence indirectly by creating distorted beliefs and attitudes about sexual assault and shift elements of blame onto the victims". Additionally, according to MacKinnon, pornography desensitizes viewers to violence against women, and this leads to a progressive need to see more violence in order to become sexually aroused, an effect she claims is well documented.
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The warm-glow model accounts for such inefficiency because impure altruists may be insensitive to the actual cause, and more sensitive to the act of giving or size of the gift. Thus, warm-glow may generate philanthropic inefficiencies to the extent that it desensitizes potential donors to the marginal impact of a given charity. In response to this concern, William MacAskill and colleagues have advanced a process of philanthropic allocation called "effective altruism". This methodology seeks to leverage logic and responsibility to identify effective charitable opportunities, thus minimizing the effect of warm-glow in the decision-making process.
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Candy cigarettes are a candy introduced in the late 19th century made out of chalky sugar, bubblegum or chocolate, wrapped in paper and packaged and branded so as to resemble cigarettes. Some products contain powdered sugar hidden in the wrapper, allowing the user to blow into the cigarette and produce a cloud of sugar that imitates smoke, which comes out of the other end. Candy cigarettes' place on the market has long been controversial because many critics believe the candy desensitizes children, leading them to become smokers later in life. Candy cigarettes can also serve as a way to market cigarettes to children, as many candy cigarettes have branding nearly identical to cigarette brands.
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A derivative of the end-around has the quarterback hand off to a running back, then pretend he still has the ball, and is giving it to the wide receiver circling behind the action. This causes the defenders who should be covering the end around to 'stay at home' and not participate in pursuing the actual ball carrier, and desensitizes the defense to the threat of the actual end-around play when it is run. The player executing the fake may be called the "ghost". Another variation has the quarterback fake the end- around handoff, then either run with the ball himself in the other direction, or pass to a receiver, including the one to whom the fake was made.
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When initially bound to PGE2 or other stimulating ligand, EP1 mobilizes G proteins containing the Gq alpha subunit (Gαq/11)-G beta-gamma complex. These two subunits in turn stimulate the Phosphoinositide 3-kinase pathway that raises cellular cytosolic Ca2+ levels thereby regulating Ca2+-sensitive cell signal pathways which include, among several others, those that promote the activation of certain protein kinase C isoforms. Since, this rise in cytosolic Ca2+ can also contract muscle cells, EP1 has been classified as a contractile type of prostanoid receptor. The activation of protein kinases C feeds back to phosphorylate and thereby desensitizes the activated EP1 receptor (see homologous desensitization but may also desensitize other types of prostanoid and non-prostanoid receptors (see heterologous desensitization).
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In men, LH levels increase by up to 800%, while testosterone levels increase to about 140 to 200% of baseline. Gradually however, the GnRH receptor desensitizes; testosterone levels peak after about 2 to 4 days, return to baseline after about 7 to 8 days, and are reduced to castrate levels within 2 to 4 weeks. Antigonadotropins such as estrogens and cyproterone acetate as well as nonsteroidal antiandrogens such as flutamide and bicalutamide can be used beforehand and concomitantly to reduce or prevent the effects of the testosterone flare caused by GnRH agonists. In contrast to GnRH agonists, GnRH antagonists, such as degarelix (Firmagon) and elagolix (Orilissa), work by binding to the GnRH receptor without activating it, thereby displacing GnRH from the receptor and preventing its activation.
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