Ms. Humphries is best known for shimmering, burbling abstract paintings that agglutinate stenciled marks, typographical stutters, and deceptive spills and splashes that in fact result from careful composition.
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Spare and simple objects, such as leaves, vases, tubes, rocks, and dirt, agglutinate in her still life photographs into more complex, interrelated wholes; in the box sculptures, found industrial objects — for example, a mining axe; a car engine heating coil — are covered in tangles of rope that resemble a game of cat's cradle gone awry.
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Sand grains agglutinate to the teleoconch in the type genus Scaliola.
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It consists of irregular volcanic blocks and rare bipolar fusiform bombs interlayered with vesicular agglutinate. A breach on the southeast side of the cone drained a central lava lake. The lava flowed southwest into the Spanish Creek valley, carrying rafts of agglutinate from the wall of the cone. Renewed volcanism on the southwestern flank of the volcano created a parasitic cone composed of loosely consolidated vesicular volcanic blocks interlayered with agglutinate.
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The name "hemagglutinin" comes from the protein's ability to cause red blood cells (erythrocytes) to clump together ("agglutinate") in vitro.
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The fungus produces the Laetiporus sulphureus lectin (LSL) which exhibits haemolytic and haemagglutination activities. Haemolytic lectins are sugar-binding proteins that lyse and agglutinate cells. These biochemical activities are promoted when bound to carbohydrates.
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In addition to identifying the ABO antigens, which is termed forward grouping, routine ABO blood typing also includes identification of the ABO antibodies in the person's plasma. This is called reverse grouping, and it is done to confirm the ABO blood type. In reverse grouping, the person's plasma is added to type A1 and type B red blood cells. The plasma should agglutinate the cells that express antigens that the person lacks, while failing to agglutinate cells that express the same antigens as the patient.
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Previous research on blood group antibodies had documented the presence of so-called "blocking" or "incomplete" antibodies: antibodies that occupied antigen sites, preventing other antibodies from binding, but did not cause red blood cells to agglutinate. Coombs and his colleagues devised a method to easily demonstrate the presence of these antibodies. They injected human immunoglobulins into rabbits, which caused them to produce an anti-human globulin antibody. The anti-human globulin could bind to antibodies already attached to red blood cells and cause them to agglutinate.
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Originally considered part of stage III, it was more recently attributed to stage IV given the considerable (6,000 years) temporal gap between the Tumbres eruption and stage III volcanism, and the geochemistry of the rocks. The Manquez agglutinate above the Tumbres deposits was formed either by the Tumbres eruption or by a subsequent stage; a pyroclastic cone in the western crater may be associated with this agglutinate. Activity subsequently shifted to the eastern edifice. Around 5150 ± 1250 BCE, as obtained by surface exposure dating, the Tumbres-Talabre lava flow was erupted from the eastern crater.
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Blood types were first discovered by an Austrian physician, Karl Landsteiner, working at the Pathological-Anatomical Institute of the University of Vienna (now Medical University of Vienna). In 1900, he found that blood sera from different persons would clump together (agglutinate) when mixed in test tubes, and not only that, some human blood also agglutinated with animal blood. He wrote a two-sentence footnote: This was the first evidence that blood variation exists in humans. The next year, in 1901, he made a definitive observation that blood serum of an individual would agglutinate with only those of certain individuals.
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Lectins occur ubiquitously in nature. They may bind to a soluble carbohydrate or to a carbohydrate moiety that is a part of a glycoprotein or glycolipid. They typically agglutinate certain animal cells and/or precipitate glycoconjugates. Most lectins do not possess enzymatic activity.
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The 'bedside card' method of blood typing, in this case using a Serafol card. The result is blood group A positive. Hemagglutination is the process by which red blood cells agglutinate, meaning clump or clog. The agglutin involved in hemagglutination is called hemagglutinin.
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Some viruses attach to molecules present on the surface of red blood cells, for example, influenza virus. A consequence of this is that – at certain concentrations – a viral suspension may bind together (agglutinate) the red blood cells thus preventing them from settling out of suspension.
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Difflugia are testate amoebae with an agglutinate shell. The test can be composed of various different mineral particles depending on the varying environment. These mineral particles are collectively called xenosomes. All species of the genus Difflugia acquire their xenosomes, from the environment in which they inhabit.
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The Anton blood group antigen is a cell surface receptor found on some human red blood cells. It has been observed to play a role in Haemophilus influenzae infections. Studies showed that bacterium can adhere to this receptor and cause human red blood cells to agglutinate.
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Several lines of evidence suggest that intelectins recognize microbes and may function as an innate immune defense protein. Tunicate intelectin is an opsonin for phagocytosis by hemocyte. Amphioxus intelectin has been shown to agglutinate bacteria. In zebrafish and rainbow trout, intelectin expression is stimulated upon microbial exposure.
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Aside from its more distinctive features, Urirana also follows a polysynthetic agglutinate word morphology in relating to verbs similar to other Amazonian languages. Many of Urarina's unique grammatical features are gradually disappearing as younger generations speak a Urarina that is being influenced by a growing bilingualism in Spanish.
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The RBCs are washed three or four times with isotonic saline solution and then incubated with antihuman globulin. If antibodies have bound to RBC surface antigens in the first stage, RBCs will agglutinate when incubated with the antihuman globulin (also known Coombs reagent) in this stage, and the indirect Coombs test will be positive.
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Lectins are considered a major family of protein antinutrients, which are specific sugar- binding proteins exhibiting reversible carbohydrate-binding activities. Lectins are similar to antibodies in their ability to agglutinate red blood cells. Many legume seeds have been proven to contain high lectin activity, termed hemagglutination. Soybean is the most important grain legume crop in this category.
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Phytohaemagglutinin (PHA, or phytohemagglutinin) is a lectin found in plants, especially certain legumes. PHA actually consists of two closely related proteins, called leucoagglutinin (PHA-L) and PHA-E. The letters E and L indicate these proteins agglutinate erythrocytes (red blood cells) and leukocytes (white blood cells) respectively. Phytohaemagglutinin has carbohydrate-binding specificity for a complex oligosaccharide containing galactose, N-acetylglucosamine, and mannose.
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Red blood cells expressing these antigens are then added to the saliva-reagent mixtures. If the person is a secretor, the antibodies will bind to the antigens in their saliva rather than the red blood cells, and will not cause red blood cells to agglutinate. Secretor status testing was historically used in forensic science, but this has been made obsolete by advances in DNA testing.
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IgM has 10 antigen binding regions per molecule, allowing cross-linking of cells. An antiserum specific for HLA-A3 will then agglutinate HLA-A3 bearing red blood cells if the concentration of IgM in the antiserum is sufficiently high. Alternatively, a second antibody to the invariable (Fc) region of the IgG can be used to cross-link antibodies on different cells, causing agglutination. Complement fixation assay.
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One species of mollusc, the scaly-foot gastropod, even makes use of the iron sulfides greigite and pyrite. Some organisms, such as some foraminifera, agglutinate exoskeletons by sticking grains of sand and shell to their exterior. Contrary to a common misconception, echinoderms do not possess an exoskeleton, as their test is always contained within a layer of living tissue. Exoskeletons have evolved independently many times; 18 lineages evolved calcified exoskeletons alone.
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Illustration showing influenza virus attaching to cell membrane via the surface protein hemagglutinin In molecular biology, hemagglutinin or haemagglutinin (British English; both ) are glycoproteins which cause red blood cells (RBCs) to agglutinate or clump together. (Note that agglutination is one of three steps in the more complex process of coagulation.) The process of the RBC's agglutinating is called hemagglutination or haemagglutination. Antibodies and lectins are commonly known hemagglutinins.
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The patient's RBCs are washed (removing the patient's own serum) and then centrifuged with antihuman globulin (also known as Coombs reagent). If immunoglobulin or complement factors have been fixed on to the RBC surface in-vitro, the antihuman globulin will agglutinate the RBCs and the direct Coombs test will be positive. (A visual representation of a positive direct Coombs test is shown in the upper half of the schematic).
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They measure 2 to 3 μm in diameter. The flesh, again, is primarily made up of skeletal hyphae with some generative hyphae. The thick-walled skeletal hyphae are a yellow-brown to rust brown, and are slightly less agglutinate. The hyphae in the flesh are a little smaller; the skeletal hyphae measure 1.8 to 3.4 μm in diameter, while the generative hyphae measure 1.5 to 2.6 μm in diameter.
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Concanavalin A interacts with diverse receptors containing mannose carbohydrates, notably rhodopsin, blood group markers, insulin-receptor the Immunoglobulins and the carcino-embryonary antigen (CEA). It also interacts with lipoproteins. ConA strongly agglutinates erythrocytes irrespective of blood-group, and various cancerous cells. It was demonstrated that transformed cells and trypsin-treated normal cells do not agglutinate at 4 °C, thereby suggesting that there is a temperature-sensitive step involved in ConA-mediated agglutination.
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Blood typing can be performed using test tubes, microplates, or blood typing slides. The tube method involves mixing a suspension of red blood cells with antisera (or plasma, for reverse grouping) in a test tube. The mixture is centrifuged to separate the cells from the reagent, and then resuspended by gently agitating the tube. If the antigen of interest is present, the red blood cells agglutinate, forming a solid clump in the tube.
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It employs latex beads covered with antigens that will visibly agglutinate around GAS antibodies if these are present. Second, a lateral flow test, which is currently the most widely used RST. The sample is applied to a strip of nitrocellulose film and, if GAS antigens are present, these will migrate along the film to form a visible line of antigen bound to labeled antibodies. Third, optical immunoassay is the newest and more expensive test.
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In cross-matching, donor red blood cells and the recipient's serum or plasma are incubated together. If agglutination occurs, this indicates that the donor and recipient blood types are incompatible. When a person produces antibodies against their own red blood cells, as in cold agglutinin disease and other autoimmune conditions, the cells may agglutinate spontaneously. This is called autoagglutination and it can interfere with laboratory tests such as blood typing and the complete blood count.
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Agglutination-PCR (ADAP) is an ultrasensitive solution-phase method for detecting antibodies. Antibodies bind to and agglutinate synthetic antigen–DNA conjugates, enabling ligation of the DNA strands and subsequent quantification by qPCR. Like other Immuno-PCR (IPCR) detection methods ADAP combines the specificity of antibody-antigen recognition and the sensitivity of PCR. ADAP detects zepto- to attomoles of antibodies in 2 μL of sample with a dynamic range spanning 5–6 orders of magnitude.
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Aside from the common morphology shared by radiolarians such as the axopodia, nucleus and metabolic organelles in internal endoplasm and the separation of external and internal endoplasm by the central capsule, most species of Collodaria form colonies in nature. Anderson et al. (1999) observed that the colony shapes are not species-specific. Colonial Collodarian cells can agglutinate in a gelatinous matrix that can be as small as a few mm to as large as 3 m in length.
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Some of these antibodies can bind to incompatible red blood cells and cause them to be destroyed, resulting in transfusion reactions and other complications. Serologic methods for blood typing make use of these antibody- antigen reactions. Reagents containing blood group antibodies, called antisera, are added to suspensions of blood cells. If the relevant antigen is present, the antibodies in the reagent will cause the red blood cells to agglutinate (clump together), which can be identified visually.
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Situated east of Spanish Lake is the northerly Spanish Lake Centre with an elevation of . It consists of an older major cone and two younger parasitic cones. The older edifice is breached in the southwest by two lava flows and contains an inner younger cone that is breached on its north side by a lava flow from a flank eruption. Both cones comprise unconsolidated irregular volcanic blocks with little agglutinate, with the inner cone incorporating weathered bipolar fusiform bombs.
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The older of the two parasitic cones is situated on the eastern rim of the major cone while the younger cone lies on the eastern flank of the older parasitic cone. Both cones contain a higher proportion of agglutinate material than the major cone. The younger parasitic cone has a deep crater, which formed during the final phase of activity of the Spanish Lake Centre. Lava flows from two flank eruptions travelled westward into the Spanish Creek valley.
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Several well-preserved spherical and breadcrust bombs as well as poorly preserved bipolar fusiform varieties occur with the irregular volcanic blocks. A breach on the south side of the cone permitted drainage of a lava lake in the crater. The most recently formed part of the Flourmill Centre is a well-preserved composite cone on the northwest flank. It partially overlies deposits from the southwestern vent and consists of loosely consolidated volcanic bombs pervasively interlayered with agglutinate.
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Todd Lake volcano, which erupted porphyritic andesite (andesite with distinct differences among its crystal size) with a pale gray color, sits at Broken Top's southern foot. Its lava flows have been exposed and are covered with red scoria and agglutinate from a separate volcanic vent. It began to erupt as Broken Top stopped eruptive activity, since the two have overlapping layers of lava. As Pleistocene glaciers retreated, basaltic cinder cone volcanoes formed south of Todd Lake right as Cayuse Crater was forming.
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Rats that have been administered a high dose of volkensin died between 7 and 12 hours. For 1-2 hours after poisoning rats behaved normally and then became sedated until death with short-lasting seizures. Rats that have been administered lower doses died within several days and showed wax-like peritoneal fat, which indicated the formation of a pancreatic lesion. In addition, volkensin has been also found to agglutinate red blood cells without any specificity for a particular blood group.
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When the antibodies bind to red blood cells that express the corresponding antigen, they cause red blood cells to clump together (agglutinate), which can be identified visually. The person's blood group antibodies can also be identified by adding plasma to cells that express the corresponding antigen and observing the agglutination reactions. Other serologic methods used in transfusion medicine include crossmatching and the direct and indirect antiglobulin tests. Crossmatching is performed before a blood transfusion to ensure that the donor blood is compatible.
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In 1941, Hirst discovered that adding influenza virus particles to red blood cells caused them to agglutinate or stick together forming a lattice, a phenomenon called hemagglutination. Hemagglutination provided a convenient method of diagnosing influenza in the laboratory, which had previously been performed by cultivating the virus in ferrets. Hirst developed this reaction into the hemagglutination assay, which allows the amount of virus in the sample to be measured. This technique is rapid, accurate and convenient, and later proved to be applicable to many other viruses.
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PDB entry 2dvd Peanut agglutinin (PNA) is plant lectin protein derived from the fruits of Arachis hypogaea. Peanut agglutinin may also be referred to as Arachis hypogaea lectin. Lectins recognise and bind particular sugar sequences in carbohydrates; peanut agglutinin binds the carbohydrate sequence Gal-β(1-3)-GalNAc. The name "peanut agglutinin" originates from its ability to stick together (agglutinate) cells, such as neuraminidase-treated erythrocytes, which have glycoproteins or glycolipids on their surface which include the Gal-β(1-3)-GalNAc carbohydrate sequence.
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There is a crescent-shaped, agglutinate ridge consisting of volcanic bombs surrounding the crater, which reaches heights of above the lake surface and above surrounding topographic features. Some of the volcanic bombs on the outer slopes of Blue Lake Crater reach lengths of ; many of the inner slopes lead to cliffs. The northern wall of the crater appears to have collapsed during an eruption, while the southern wall is intact and made of cinder and a matrix of bedrock and volcanic bombs. Overall, Blue Lake Crater has a modest volcanic cone.
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To combat pathogens that replicate outside cells, antibodies bind to pathogens to link them together, causing them to agglutinate. Since an antibody has at least two paratopes, it can bind more than one antigen by binding identical epitopes carried on the surfaces of these antigens. By coating the pathogen, antibodies stimulate effector functions against the pathogen in cells that recognize their Fc region. Those cells that recognize coated pathogens have Fc receptors, which, as the name suggests, interact with the Fc region of IgA, IgG, and IgE antibodies.
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Isoantibodies are seen in people with different blood groups. The anti-A or anti-B isoantibodies or both (also called isohaemagglutinins) are produced by an individual against the antigens (A or B) on the RBCs of other blood groups. In a person with A blood group, the plasma will contain isoantibodies against B antigens, so immediately after transfusion of blood from B group the anti-B isohemagglutinins agglutinate the foreign red blood cells. Anti-A and anti-B antibodies (called isohaemagglutinins), which are not present in human babies, appear in the first years of life.
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Illustration of the effects of excess antigen and blocking antibodies on immunoassays. In an agglutination test, a person's serum (which contains antibodies) is added to a test tube, which contains a particular antigen. If the antibodies agglutinate with the antigen to form immune complexes, then the test is interpreted as positive. However, if too many antibodies are present that can bind to the antigen, then the antigenic sites are coated by antibodies, and few or no antibodies directed toward the pathogen are able to bind more than one antigenic particle.
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S P Crater is an high cinder cone of basaltic andesite. The cone is capped by an agglutinate rim that helps to protect its structure. A lava flow extends to the north of the cone for about and originated from the same vent. Some scientists consider the lava flow to have slightly predated the cinder cone because of geochemical data that suggests the flow is more silica rich than the cinders and based on the observation that the cone overlaps the lava flow and shows no sign of deformation.
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This increased binding causes vWD because the high-molecular weight multimers are removed from circulation in plasma since they remain attached to the patient's platelets. Thus, if the patient's platelet-poor plasma is used, the ristocetin cofactor assay will not agglutinate standardized platelets (i.e., pooled platelets from normal donors that are fixed in formalin), similar to the other types of vWD. In all forms of the ristocetin assay, the platelets are fixed in formalin prior to the assay to prevent von Willebrand's factor stored in platelet granules from being released and participating in platelet aggregation.
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It is possible to construct artificially extreme examples of agglutination, which have no real use, but illustrate the theoretical capability of the grammar to agglutinate. This is not a question of "long words", because some languages permit limitless combinations with compound words, negative clitics or such, which can be (and are) expressed with an analytic structure in actual usage. English is capable of agglutinating morphemes of solely Germanic origin, as un-whole-some-ness, but generally speaking the longest words are assembled from forms of Latin or Ancient Greek origin. The classic example is antidisestablishmentarianism.
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In 2009, Governor of Oregon Ted Kulongoski signed a bill designating the Metolius River basin as an area of critical concern, preventing large-scale development on the land and protecting its wildlife. Despite having erupted at some point within the past 4,000 years, Blue Lake Crater is considered one of the least-known Holocene volcanoes in the Cascade volcanic arc. It forms a modest volcanic cone, its lake surrounded by a crescent-shaped, agglutinate ridge consisting of volcanic bombs. The northern side of Blue Lake Crater's rim collapsed during eruptive activity, while the southern wall remains intact.
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Cold agglutinins (CA) are autoantibodies that agglutinate RBCs with a temperature optimum of 3-4 °C but may also act in a warmer environment, depending on the thermal amplitude of the CA. If the thermal amplitude exceeds 28–30 °C, the CA will be pathogenic. Low-affinity CA also occurs in many healthy individuals; these nonpathogenic CA are polyclonal, have low thermal amplitude, and are present in low titers, not higher than 256 and usually lower than 64. More than 90% of pathogenic CA are of the IgM class and these IgM macromolecules can be pentameric or hexameric.
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Psammoactinia antarctica was an encrusting, colonial cnidarian in the family Hydractiniidae that lived in the Cretaceous Antarctic. Within its family, P. antarctica had the unusual ability to agglutinate sand and silt grants, incorporating them into the basal layer and pillars making up the wall of the chambers of its laminae. It encrusted gastropod shells inhabited by hermit crabs of the genus Paguristes. The Psammoactinia colony began with a larva landing on a small gastropod shell. The colony then grew past the aperture of the shell and formed a tube that conformed to the hermit crab’s shape and growing pattern.
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The sticky surface of these long egg strings allows them to coil and agglutinate, mixing with the surrounding sand to form compact egg masses, the shape of which is defined by the anterior portion of the outer lip of the female's shell while they are layered. Each one of the egg masses may have been fertilized by multiple males. The number of eggs per egg mass varies greatly depending on environmental conditions such as food availability and temperature. Commonly, females produce 8–9 egg masses per season, each containing 180,000–460,000 eggs, but numbers can be as high as 750,000 eggs.
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Many viruses attach to molecules present on the surface of RBCs. A consequence of this is that at certain concentrations, a viral suspension may bind together (agglutinate) the RBCs, thus preventing them from settling out of suspension. Since agglutination is not linked to infectivity, attenuated viruses can therefore be used in assays while an additional assay such as a plaque assay must be used to determine infectivity.By serially diluting a virus suspension into an assay tray (a series of wells of uniform volume) and adding a standard amount of blood cells, an estimation of the number of virus particles can be made.
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Like most other studied perivitellins from Pomacea snails, PV2s are highly stable in a wide range of pH values and withstand gastrointestinal digestion, characteristics associated with an antinutritive defense system that deters predation by lowering the nutritional value of the eggs. PV2s have both lectin and perforin activities, which are related to the two different subunits found in their particular structures. As a lectin, PV2s can agglutinate rabbit red blood cells and bind to the plasma membrane of intestinal cells both in vitro and in vivo. As a perforin, PV2s are able to disrupt intestinal cells altering the plasma membrane conductance and to form large pores in artificial lipid bilayers.
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To perform the test, a blood sample is taken and the red blood cells are washed (removing the patient's own plasma and unbound antibodies from the red blood cells) and then incubated with anti- human globulin ("Coombs reagent"). If the red cells then agglutinate, the direct Coombs test is positive, a visual indication that antibodies or complement proteins are bound to the surface of red blood cells and may be causing destruction of those cells. The indirect Coombs test is used in prenatal testing of pregnant women and in testing prior to a blood transfusion. The test detects antibodies against foreign red blood cells.
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In the Ore Mountains (Erzgebirge) which form the border between Czechia and Germany, western Bohemia and the Vogtland region have been known since the 16th century as frequently prone to earthquake swarms which typically last a few weeks to a few months. Austrian geologist Josef Knett, while studying in 1899 a swarm of about a hundred events felt in western Bohemia/Vogtland in January-February 1824, coined the noun Schwarmbeben, i.e. "swarm [earth]quake". The term "swarm" is explained by hypocentres giving the impression to agglutinate like a bee swarm when plotted onto a map, a cross-section, or still better onto a 3D model.
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Therefore, blood typing using IgG antisera requires incubation at and use of the indirect antiglobulin test to demonstrate IgG bound to red blood cells. To type antigens by the indirect antiglobulin test, antisera against the relevant antigen is added to a suspension of red blood cells, then incubated at , the ideal temperature for reactivity of IgG antibodies. After incubation, the red blood cells are washed with saline to remove unbound antibodies, and anti- human globulin reagent is added. If the IgG antibodies in the reagent have bound to the antigen on the cell surface, anti-human globulin will bind to those antibodies, causing the red blood cells to agglutinate after centrifugation.
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Successively, 24 isolates of L. garvieae from different fish species and geographic origin were studied by slide cohesion tests. These tests were conducted using rabbit antisera against representative strains with diverse origins and by Dot blot assays. These results endorsed the establishment of two different groups of isolates, but a correlation between serological group and geographic origin or host source could not be determined. Barnes and Ellis serologically compared 17 geographically distinct strains of L. garvieae isolated from diseased rainbow trout, finding that sera raised against capsule deficient isolates did not agglutinate capsulated isolates, whereas all antisera against capsulated strains cross reacted with non-capsulated isolates.
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This occurs in biology in two main examples: # The clumping of cells such as bacteria or red blood cells in the presence of an antibody or complement. The antibody or other molecule binds multiple particles and joins them, creating a large complex. This increases the efficacy of microbial elimination by phagocytosis as large clumps of bacteria can be eliminated in one pass, versus the elimination of single microbial antigens. # When people are given blood transfusions of the wrong blood group, the antibodies react with the incorrectly transfused blood group and as a result, the erythrocytes clump up and stick together causing them to agglutinate.
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Dane's determination to improve the accuracy of detecting the hepatitis B surface antigen protein, HBsAg, and his keen interest in blood transfusion led him to accept an honorary consultancy at NLBTC which he continued to hold after his retirement in 1982, until his death. Through this association with the blood services Dane went on both to improve current assays and to develop more sensitive screening methods. A close collaboration with Ian Cayzer in Wellcome Diagnostics produced the haemagglutination assay for HBsAg, "Hepatest". Turkey red blood cells, coated with antibody to HBsAg agglutinate (clump together) in the presence of HBsAg, a sensitive test which was widely used diagnostically.
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The sculptured decoration of the dome was also beautifully crafted by hitherto unknown craftsmen. It is dated between 380 and 370 BC. High reliefs ascribed the figures of the metopes, which contributed to being easily detached from the plates and be reused as building material and tomb covers in the early Christian years after they were smoothed over again. Following strenuous and time-consuming efforts of specialists who attempted to agglutinate the fragments around the monument, we can today have at least an incomplete picture of its original form and the stylistic and decorative elements of its relief representations. In the major metopes of the outer side there are scene representations from Amazon and Centaur battles, already known from mythology and very dear to Greek sculpture.
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Some of the red blood cells are agglutinated, while others are not, making it difficult to interpret the result. This is called a mixed field reaction, and it can occur if someone has recently received a blood transfusion with a different blood type (as in a type A patient receiving type O blood), if they have received a bone marrow or stem cell transplant from someone with a different blood type, or in patients with certain ABO subgroups, such as A3. Investigation of the person's medical history can clarify the cause of the mixed field reaction. People with cold agglutinin disease produce antibodies against their own red blood cells that cause them to spontaneously agglutinate at room temperature, leading to false positive reactions in forward grouping.
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In damp weather, a Polysphondylium pallidum myxamoeba can move around at a speed of about per hour, leaving a chemical trail behind it. When it finds the trail left by another myxamoeba, it follows it, superimposing its own trace signal, and more and more individuals collect together in this way. Under favourable conditions, the myxamoebae agglutinate and stick together to form a "pseudoplasmodium" in which they remain separate individuals but behave as if the whole mass was a single organism. The pseudoplasmodium can move around and in due course develops into a fruiting body called a sporangium, about a third of the cells forming a stalk and the remaining cells forming a ball at the top where they develop into spores.
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Cold agglutinin disease (CAD) is a rare autoimmune disease characterized by the presence of high concentrations of circulating cold sensitive antibodies, usually IgM and autoantibodies that are also active at temperatures below , directed against red blood cells, causing them to agglutinate and undergo lysis. It is a form of autoimmune hemolytic anemia, specifically one in which antibodies bind red blood cells only at low body temperatures, typically 28–31 °C. When affected people's blood is exposed to cold temperatures ( to ), certain proteins that normally attack bacteria (IgM antibodies) attach themselves to red blood cells and bind them together into clumps (agglutination). This eventually causes red blood cells to be prematurely destroyed (hemolysis) leading to anemia and other associated signs and symptoms.
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The outer surface of the peridium has hyphae that agglutinate so as to form a texture with visible filaments, a condition known as fibrillose; this outer layers of hairs typically wears off with age to leave a relatively smooth surface. Cross section of C. laeve fruiting bodies in various stages of developmentYoung specimens have a thin layer of tissue called an epiphragm that covers the top of the peridium; it wears off at maturity to expose the peridioles within. There are usually 4–6 peridioles (up to 15 have been noted for C. laeve) that are disc-shaped, whitish in color, and attached to the endoperidium by a strand called a funicular cord. Made of mycelia, The funicular cord tends to wither away and disappear as the fruiting body ages.
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Karl Landsteiner circa 1930 In 1901, Karl Landsteiner published the results of an experiment in which he mixed the serum and red blood cells of five different human donors. He observed that a person's serum never agglutinated their own red blood cells, but it could agglutinate others', and based on the agglutination reactions the red cells could be sorted into three groups: group A, group B, and group C. Group C, which consisted of red blood cells that did not react with any person's plasma, would later be known as group O. A fourth group, now known as AB, was described by Landsteiner's colleagues in 1902. This experiment was the first example of blood typing. In 1945, Robin Coombs, A.E. Mourant and R.R. Race published a description of the antiglobulin test (also known as the Coombs test).
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Some German researchers had also discovered the diphtheria toxin and were trying to immunize some guinea pigs through the use of a vaccine: one of them, Von Behring, Robert Koch's student, stated that he was able to weaken small doses of the toxin. Nonetheless Roux was not convinced by this result, since no-one knew the collateral effects of the procedure, and preferred to use serotherapy since more than one lab study – like the one accomplished by Charles Richet – demonstrated that the serum of an animal vaccinated against the disease included the antibodies needed to defeat it. The anti-diphtheria serum which was able to agglutinate the bacteria and neutralize the toxin was supplied by a horse inoculated with the viral germs, and it was separated from the blood drawn from the horses’ jugular vein. Like it happened for his teacher with the anti-rabies vaccine, Roux needed to test the effectiveness of the product he elaborated, and endured all the stress and ethical dilemmas that the first use of such a risky but also groundbreaking procedure implied.
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