But when food is scarce, our system uncouples from the light-dark cycle to allow for more time to find food, helping you adjust more quickly to your new time zone.
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It uncouples the drone's positioning from the camera controls, so that you can set the Solo to follow someone, and use the controller to manipulate the camera and perfect the framing.
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The internet uncouples dating from other social activities which might comfort a shy or spurned heart in the offline world; love's vicissitudes can be harder when taken away from the context of a club or church hall.
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Amid their business-as-usual shenanigans, Ilana buckles down to apply to grad school programs for psychology and consciously uncouples with Lincoln (teardrop), while Abbi dates an older female doctor and makes the tough choice to leave her city adventures behind for art school in Boulder, Colorado.
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It also uncouples oxidative phosphorylation, the process cells use to synthesize Adenosine triphosphate which they use for energy. In addition, A23187 inhibits mitochondrial ATPase activity. A23187 also induces apoptosis in some cells (e.g. mouse lymphoma cell line, or S49, and Jurkat cells) and prevents it in others (e.g.
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Instead, he set about killing them all. Turbé uncouples the dining car, leaving it to be destroyed by a following train. The gang try to escape from the front of the car, but the door is locked; they are killed. Harwood and Fenton survive by escaping from the back.
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Devereau's men had also disabled the emergency brakes. With the help of a steward (Scatman Crothers), George uncouples the passenger cars from the engine. The runaway engine roars at full speed into Chicago's Union Station, destroying everything in its path. The uncoupled passenger cars glide safely into the station.
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The FSHR become desensitized when exposed to FSH for some time. A key reaction of this downregulation is the phosphorylation of the intracellular (or cytoplasmic) receptor domain by protein kinases. This process uncouples Gs protein from the FSHR. Another way to desensitize is to uncouple the regulatory and catalytic units of the cAMP system.
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The LHCGRs become desensitized when exposed to LH for some time. A key reaction of this downregulation is the phosphorylation of the intracellular (or cytoplasmic) receptor domain by protein kinases. This process uncouples Gs protein from the LHCGR. Another way to desensitize is to uncouple the regulatory and catalytic units of the cAMP system.
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Winslow took her away because Randolph would never have married so far beneath him socially. McQueen, however, is undeterred. The day of the robbery, a suspicious McQueen talks to Wallace's wife and discovers he has betrayed the gang for the reward money. Forewarned, McQueen uncouples the passenger cars in which the sheriff and his men are waiting in ambush, leaving them behind.
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Toad confesses the truth and begs the driver to help him evade his captors. If only to protect his train, the driver agrees to help. He tosses coal at the police, but gets caught in a mail catcher. Toad takes control of the train, Mole accidentally uncouples the coaches and Rat and Mole were left far behind, Toad eventually derails the engine.
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It is not practical on larger ploughs. When an obstruction is encountered, the spring release mechanism in the hitch permits the plough to uncouple from the tractor. When a hydraulic lift is used on the plough, the hydraulic hoses will also usually uncouple automatically when the plough uncouples. Most plough makers offer an automatic reset system for tough conditions or rocky soils.
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The phosphorylation of PAR1's cytoplasmic tail and subsequent binding to arrestin uncouples the protein from G protein signaling. These phosphorylated PAR1s are transported back into the cell via endosomes where they are sent to Golgi bodies. The cleaved PAR1s are then sorted and transported to lysosomes where they are degraded. This internalization and degradation process is necessary for the termination of receptor signaling.
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Joker's hired thugs, Donner and Blitzen, blow up one of Gotham's bridges, just as the 11:30 train is about to cross. Gleeson reveals that her mother is on the train, prompting a taunt from Joker. Batman and Robin hurry to intercept the train. Robin uncouples the passenger cars, while Batman rescues the engineer just in time for the train to careen off the blown-up tracks and into the valley below.
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By competing with phosphate, arsenate uncouples oxidative phosphorylation, thus inhibiting energy-linked reduction of NAD+, mitochondrial respiration and ATP synthesis. Hydrogen peroxide production is also increased, which, it is speculated, has potential to form reactive oxygen species and oxidative stress. These metabolic interferences lead to death from multi-system organ failure. The organ failure is presumed to be from necrotic cell death, not apoptosis, since energy reserves have been too depleted for apoptosis to occur.
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As the crew prepares to return, Mother III suddenly uncouples from the Demeter, leaving them stranded with no means of communication. Later, cargo specialist 187 (Coolio) and deckhand Humvee (Tiny Lister) discover a cargo bay full of coffins. 187 speculates that the coffins could contain smuggled goods and opens one, only to find sand. Humvee heads back to the bridge while 187 stays to open the other coffins; he is soon mysteriously attacked.
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ROS increases uncoupling proteins (UCPs) and potentiate proton leakage through the adenine nucleotide translocator (ANT), the combination of which uncouples the mitochondria. Uncoupling then increases oxygen consumption by the mitochondria, compounding the increase in fatty acid oxidation. This creates a vicious cycle of uncoupling; furthermore, even though oxygen consumption increases, ATP synthesis does not increase proportionally because the mitochondria are uncoupled. Less ATP availability ultimately results in an energy deficit presenting as reduced cardiac efficiency and contractile dysfunction.
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In this way, the short form of Homer uncouples mGluR signaling and also shrinks dendritic spine structure. Therefore, the short form of Homer is considered to be a part of a mechanism of homeostatic plasticity that dampens the neuronal responsiveness when input activity is too high. The long form Homer1c plays a role in synaptic plasticity and the stabilization of synaptic changes during long-term potentiation. The coiled-coil domain is reported to interact with syntaxin13 and activated Cdc42.
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Harry throws Leon from the cab, at which the hitman vows to get them even if it takes another 30 years. Archie then takes Richie back to the coaches and uncouples the train, advising Richie to tell the police that he was kidnapped. Harry and Archie drive 4449 at full throttle through a fusillade of bullets from U.S. border police. They crash through, burying the engine partially in the soil of Mexico a few feet across the border.
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Tissue culture studies have shown that arsenic compounds block both IKr and Iks channels and, at the same time, activate IK- ATP channels. Arsenic compounds also disrupt ATP production through several mechanisms. At the level of the citric acid cycle, arsenic inhibits pyruvate dehydrogenase and by competing with phosphate it uncouples oxidative phosphorylation, thus inhibiting energy-linked reduction of NAD+, mitochondrial respiration, and ATP synthesis. Hydrogen peroxide production is also increased, which might form reactive oxygen species and oxidative stress.
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However, during the adaptation to reproductively inhibitory photoperiods, the levels of T3 decrease due to peri-hypothalamic DIO3 expression that catabolizes T4 and T3 into receptor inactive amines . Deiodinase 2 also plays a significant role in thermogenesis in brown adipose tissue (BAT). In response to sympathetic stimulation, dropping temperature, or overfeeding BAT, D2 increases oxidation of fatty acids and uncouples oxidative phosphorylation via uncoupling protein, causing mitochondrial heat production. D2 increases during cold stress in BAT and increases intracellular T3 levels.
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Aspirin has been shown to have at least three additional modes of action. It uncouples oxidative phosphorylation in cartilaginous (and hepatic) mitochondria, by diffusing from the inner membrane space as a proton carrier back into the mitochondrial matrix, where it ionizes once again to release protons. Aspirin buffers and transports the protons. When high doses are given, it may actually cause fever, owing to the heat released from the electron transport chain, as opposed to the antipyretic action of aspirin seen with lower doses.
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Rottlerin also uncouples mitochondria at high doses and results in depolarization of the mitochondrial membrane potential. It was found to reduce ATP levels, activate 5'-AMP- activated protein kinase and affect mitochondrial production of reactive oxygen species (ROS). It is difficult to say that rottlerin is a selective inhibitor of PKCδ since there are biological and biochemical processes that are PKCδ –independent that may affect outcomes. A proposed mechanism of why rottlerin was found to inhibit PKCδ is that it decreased ATP levels and can block PKCδ tyrosine phosphorylation and activation.
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Aspirin has been shown to have three additional modes of action. It uncouples oxidative phosphorylation in cartilaginous (and hepatic) mitochondria, by diffusing from the intermembrane space as a proton carrier back into the mitochondrial matrix, where it ionizes once again to release protons. In short, aspirin buffers and transports the protons, acting as a competitor to ATP synthase. When high doses of aspirin are given, aspirin may actually cause hyperthermia due to the heat released from the electron transport chain, as opposed to the antipyretic action of aspirin seen with lower doses.
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Chlorfenapyr works by disrupting the production of adenosine triphosphate, specifically, "Oxidative removal of the N-ethoxymethyl group of chlorfenapyr by mixed function oxidases forms the compound CL 303268. CL 303268 uncouples oxidative phosphorylation at the mitochondria, resulting in disruption of production of ATP, cellular death, and ultimately organism mortality." Chlorfenapyr is also used as a wool insect-proofing agent, and was introduced as an alternative to synthetic pyrethroids due to a lower toxicity to mammalian and aquatic life. In April 2016, in Pakistan, 31 people died when their food was spiked with chlorfenapyr.
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UCP1-mediated heat generation in brown fat uncouples the respiratory chain, allowing for fast substrate oxidation with a low rate of ATP production. UCP1 is related to other mitochondrial metabolite transporters such as the adenine nucleotide translocator, a proton channel in the mitochondrial inner membrane that permits the translocation of protons from the mitochondrial intermembrane space to the mitochondrial matrix. UCP1 is restricted to brown adipose tissue, where it provides a mechanism for the enormous heat-generating capacity of the tissue. UCP1 is activated in the brown fat cell by fatty acids and inhibited by nucleotides.
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While the utilisation of the trains in the Thale-Quedlinburg area rose by 5 to 15 percent between 1998 and 2005, it remained about the same on the Quedlinburg–Halberstadt section.Determination of the public transport plan of Saxony-Anhalt in 2005 for the period until 2015 The Harz-Berlin-Express (Berlin Ostbahnhof – Potsdam – Magdeburg – Thale) has offered a continuous connection for visitors from the Berlin area at the weekend since December 2005. Trains from Berlin Ostbahnhof via Halberstadt (where the train uncouples from the train towards Ilsenburg and Vienenburg) to Thale Hbf depart on Saturday and Sunday morning and Sunday evenings.
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Label-free quantification may be based on precursor signal intensity or on spectral counting. The first method is useful when applied to high precision mass spectra, such as those obtained using the new generation of time-of-flight (ToF), fourier transform ion cyclotron resonance (FTICR), or Orbitrap mass analyzers. The high-resolution power facilitates the extraction of peptide signals on the MS1 level and thus uncouples the quantification from the identification process. In contrast, spectral counting simply counts the number of spectra identified for a given peptide in different biological samples and then integrates the results for all measured peptides of the protein(s) that are quantified.
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Unlike the importance of phosphate in glycolysis, the presence of arsenate restricts the generation of ATP by forming an unstable anhydride product, through the reaction with D-glyceraldehyde-3-phosphate. The anhydride 1-arsenato-3-phospho-D-glycerate generated readily hydrolyzes due to the longer bond length of As-O compared to P-O. At the mitochondrial level, arsenate uncouples the synthesis of ATP by binding to ADP in the presence of succinate, thus forming an unstable compound that ultimately results in a decrease of ATP net gain. Arsenite (III) metabolites, on the other hand, have limited effect on ATP production in red blood cells.
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A girl who auditioned for a part on LilyMu but lost out to Mitsuki, whom she has never forgiven. She began to plot revenge against her in Mitsuki Vanishes. She stole Mitsuki's train ticket out of Mikey's pocket so Mitsuki couldn't leave with the others, kidnapped Mitsuki, tied her up and smuggled her aboard the train, only to have Mikey discover Mitsuki tied up and realize something was wrong and convince the others of what he saw. After Mikey and the others grill other suspects, Reiko fesses up, then uncouples the gang's train coach from the rest of the train so she can complete her revenge on Mitsuki.
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Frank observes that 777's rear car has an open coupler and proposes that they travel in reverse and catch up to the 777 in an attempt to couple their engine to the runaway and then use their own brakes to slow down 777 before it reaches the Stanton curve. Will uncouples 1206 from their own cars, while Frank reports his plan to Connie and Galvin, warning that Galvin's derailing idea will not work given 777's momentum. Galvin threatens to fire Frank, who informs Galvin that AWVR has already given Frank a forced, half-benefits, early-retirement notice. Galvin threatens to fire Will as well, but both Frank and Will ignore him and pursue 777.
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The functions of TADs are not fully understood and still is a matter of debate. Most of the studies indicate TADs regulate gene expression by limiting the enhancer-promoter interaction to each TAD, however, a recent study uncouples TAD organization and gene expression. Disruption of TAD boundaries are found to be associated with wide range of diseases such as cancer, variety of limb malformations such as synpolydactyly, Cooks syndrome, and F-syndrome, and number of brain disorders like Hypoplastic corpus callosum and Adult-onset demyelinating leukodystrophy. The mechanisms underlying TAD formation are also complex and not yet fully elucidated, though a number of protein complexes and DNA elements are associated with TAD boundaries.
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One inhibitor, dicholoroacetate (DCA), binds at the center of the R domain. Within the active site, there are three amino acid residues, R250, T302, and Y320, that make the kinase resistant to the inhibitor dichloroacetate, which uncouples the active site from the allosteric site. This supports the theory that R250, T302, and Y320 stabilize the "open" and "closed" conformations of the built-in lid that controls the access of a nucleotide into the nucleotide-binding cavity. This strongly suggests that the mobility of ATP lid is central to the allosteric regulation of PDHK2 activity serving as a conformational switch required for communication between the active site and allosteric sites in the kinase molecule.
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Smokey uses his hairpin to repair the throttle as the train drifts across the ice to realign with the tracks moments before the ice breaks. The boy returns the girl's ticket for the conductor to punch, and as the three return to the passenger car, the Hobo uses a Scrooge puppet, taunting the boy and calling him a doubter. The train arrives at the North Pole, where the conductor announces that one of the passengers will be chosen to receive the first gift of Christmas from Santa himself. Discovering Billy still alone in the observation car, the girl and boy persuade him to come along, but the boy accidentally uncouples the car, sending it back along the line to a railway turntable in Santa's workshop.
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A train (or an individual car) can be pushed halfway across the gauge- changer, uncoupled, and then (once far enough across) coupled to the new locomotive and pulled the rest of the way. A long length of wire-rope with hooks on the end means that the process can be asynchronous, with the rope used to bridge across the length of the gauge changer (to temporarily couple the arriving cars and receiving locomotive, although without braking control from the locomotive to the train vehicles). On long-distance trains in Spain and night trains crossing from Spain into France, the arriving locomotive stops just short of the gauge changer, uncouples and moves into a short siding out of the way. Gravity then moves the train through the gauge changer at a controlled low speed.
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YopT targets Rho GTPase, commonly named "RhoA", and uncouples it from the membrane, leaving it in an inactive RhoA-GDI (guanine nucleotide dissociation inhibitor)-bound state whereas YopE and YpkA convert Rho proteins to their inactive GDP-bound states by expressing GTPase activity. YpkA also catalyses serine autophosporylation, so it may have regulatory functions in Yersinia or undermine host cell immune response signal cascades since YpkA is targeted to the cytoplasmic side of the host cell membrane. YopH acts on host focal adhesion sites by dephosphorylating several phosphotyrosine residues on focal adhesion kinase (FAK) and the focal adhesion proteins paxillin and p130. Since FAK phosphorylation is involved in uptake of yersiniae as well as T cell and B cell responses to antigen-binding, YopH elicits antiphagocytic and other anti-immune effects.
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The enhancement of glycogenolysis can further be supported by the interference of sanguinarine in the uptake of glucose through blocking of sodium pump via Na+-K+-ATPase and thereby inhibiting the active transport of glucose across intestinal barrier. It is well established that increased pyruvate concentration in blood uncouples oxidative phosphorylation, and this may be responsible for thickening of interalveolar septa and disorganized alveolar spaces in lungs of argemone oil-fed rats and the breathlessness as has been observed in human victims. Cardiac Failure:The inhibition of Na+-K+-ATPase activity of heart by sanguinarine is due to interaction with the cardiac glycoside receptor site of the enzyme, which may be responsible for producing degenerative changes in cardiac muscle fibers in the auricular wall of rats fed argemone oil and could be related to tachycardia and cardiac failure in Epidemic Dropsy patients. Delayed clearance:Destruction of hepatic cytochrome P450 significantly affects the metabolic clearance by liver,.
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Mice with conditional knock-outs in MACF1 in hair follicle stem cells have defects in cell migration. The focal adhesions in cells lacking MACF1 associate with cables of F-actin, causing cell migration to stall. Wild-type cells with MACF1 present have coordinated cytoskeletal dynamics, which allow for proper cell migration. MACF1 plays an important role in microtubule organization, and without MACF1, microtubules in migrating cells are bending and curly, instead of straight and radial. When wounded, conditional knock-outs for MACF1 have around a 40% delay in migration over 4 to 6 days after injury compared to the wild-type controls, showing that MACF1 plays an important role in cell migration. There are suggestions that imply that MACF1 may play a role in golgi polarization. The major known regulator of MACF1 is GSK3β, which when uninhibited phosphorylates MACF1 among its many other substrates and uncouples MACF1 from microtubules. The phosphorylation of MACF1 occurs in the GSR domain, which is involved in microtubule binding, and has 32% of the amino acid residues are serines or threonines. MACF1 has 6 serines, which are possible GSK3β phosphorylation sites.
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