This is often to offset the sedating effects of weed.
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Klonopin is a strongly sedating drug with a long half-life.
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With non-sedating antihistamines, however, none of the symptoms seemed to improve.
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Sedating antihistamines such as Benadryl and Advil PM are also bad for balance.
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Throughout the seven-hour drive, he injected her with sedating drugs on the hour.
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Sobriety and spending are questionable near Sunday as the sun squares off with sedating Neptune.
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Diphenhydramine is an active, sedating ingredient in over-the-counter antihistamines, the police news release states.
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The team stopped all potentially sedating medications to see if they were contributing to the problem.
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It also has sedating effects and is often used as an anti-anxiety and sleep aid.
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"And alcohol or any sedating medications [can cause snoring] because they contribute to muscle relaxation," Dr. Suurna explains.
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Popularized by none other than Elvis Presley, the Sleeping Beauty Diet involves heavily sedating oneself for several days.
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At low doses, it's stimulating, like a strong cup of coffee; at higher doses, it's sedating and kills pain.
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"Those two antihistamines seem to help the skin nicely, and are less sedating than say, a Benadryl is," he says.
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The girl's mother, Betty Squier, said the dental office had told her that sedating young patients was common and safe.
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Depressants include alcohol, benzodiazepines like Xanax and Klonopin, Z drugs for sleep and other drugs that have a sedating effect.
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In actuality, my aunt was sedating my mother, which she later claimed she did to ease my mother's mental afflictions.
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KidsTown works with children with developmental disorders and helps them feel comfortable at the dentist's office without restraining or sedating them.
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Gill has set up special tanks dedicated to "sedating" lobsters before their prepared for her customers, but only upon their request.
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In a whir of motion and fatigue green, they stoop over Dafna, soothing and sedating her, then tucking her in bed.
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After the authorities found the person sleeping, they handcuffed the person, requested the injection and laughed as paramedics were sedating the individual.
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In January, it is alleged he sexually abused a female patient being treated for shoulder pain after sedating her with additional medication.
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Both visitors and animal advocates have accused Tiger Temple of sedating its tigers so that visitors may approach them without being attacked.
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While the men wrestle with their impulses, Dr. Dibs performs her own rape, sedating Monte and "extracting" his sperm while he sleeps.
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It's almost like using drugs for the opposite effect—if you're agitated you might take something more sedating to calm the anxiety.
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During the time it used Foundation Care's drug to execute 17 people, Missouri had a practice of heavily sedating inmates before witnesses were escorted in.
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Todd Sauvageau says that decisions on sedating suspects are to be made by Hennepin County paramedics, not city police officers, the Minneapolis Star-Tribune reported .
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Alongside a photo of the reunion, they explained that after sedating the cats they check to see if any of the felines have a microchip.
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This was the Crete, Miller wrote, that can "hush the mind, still the bubble of thought, " though the blistering heat had a sedating effect, too.
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Rangers caught the 4.7 meter (15.4 feet) male crocodile 60 km (37 miles) downstream from the town of Katherine, on Monday after sedating it, media reported.
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But then the doctor saw that in addition to taking an antidepressant — a recommended treatment for anxiety — the patient was on a sedating medication called clonazepam.
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Federal health officials recently issued a strong warning to consumers about the risks of combining sedating drugs, like Xanax or Valium, with pain medications like opiates.
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The elders dismissed their complaints until it was discovered that men from the community had been creeping through windows at night, sedating and raping the women.
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Harris, a physician specializing in anesthesia, was responsible for sedating the boys before they were brought out one-by-one on a rescue stretcher through flooded tunnels.
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It took a few tries, but after safely corralling and sedating Bonnie, they were able to move her onto a truck that took her to Farm Sanctuary.
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The alternative would've been to give the patients sedating medications, which can interfere with their ability to participate in awake surgery and help with the brain mapping.
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In their BBC interviews, the medical workers said that they had taken immediate measures to protect the Skripals from brain damage, sedating them heavily to slow their metabolism.
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The couple runs a koala hospital in their home and treat the injured animals by sedating them when possible, cleaning their scorched fur and applying cream to burns.
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In one review, which covered four randomized controlled trials with a total of 1,466 adult participants, sedating antihistamines helped with runny nose and sneezing symptoms but not nasal congestion.
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He said that possible scenarios for removing the livestock from the park might include sedating them to ferry them back to Cedar Island, or transporting them with a trailer.
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Today the drug is listed on the World Health Organization's list of essential medicines needed in a health system because of its utility in sedating patients before medical procedures.
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But avoid sedating antihistamines — an ingredient in multi-symptom relief products — because it can have side effects including dry mouth, urinary retention, and in some cases, possible memory impairment.
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It's not clear from the study how much alcohol, if any, is safe to consume when taking drugs known to be sedating when mixed with alcohol, Cousins said by email.
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ELSEWHERE > Maine: A businesswoman who makes her livelihood selling lobsters for dining purposes is experimenting with sedating the crustaceans using marijuana to ease their pain during cooking (Mount Desert Islander).
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The beer contains pinene and myrcene—a terpene shared by both hops and indica strains of marijuana that give the plants their "dankness" characteristics and has sedating effects, according to Meadows.
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While we were on the phone, Crownover told me Moore had been delirious, and without sedating him into a coma-like trance, the doctors there were worried about what might happen.
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The suit, which was filed Monday, claims the Anchorage dentist committed a wild range of charges—most egregiously, defrauding Medicaid of $1.8 million by sedating patients using IV anesthetic for simple procedures.
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Science, he says, could even settle the perennial debate over whether there are, in fact, two types of cannabis: sativa, said to provide uplifting, cerebral sensations, and indica, considered to be sedating.
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If talking the patient down by the nurse or doctor was unsuccessful, they could rush the violent person and get them immobilized for long enough to get a shot of something sedating in.
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O'Nolan quickly discovered that Robbie was a pharmacy resident in emergency medicine at a Tampa hospital, and he had recently published a study about sedating adults with a combination of two powerful tranquilizers.
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One limitation of the study is that researchers lacked data on participants' use of a wide variety of nonprescription medicines that are also thought to have a sedating effect made worse by alcohol.
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The man claimed to be regularly taking carfentanil—a drug 10,503 times stronger than morphine and 100 times more potent than fentanyl—which is only approved for use in sedating large animals, like elephants.
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Chief Petty Officer Edward Gallagher and other Navy SEALs gave the young captive medical aid that day in Iraq in 2017, sedating him and cutting an airway in his throat to help him breathe.
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Also, while opioids tend to be sedating, kratom initially has a stimulating effect— users compare it to a serious caffeine buzz, and indeed, the plant is a member of the same species as coffee.
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But I found Valium to be way more sedating, which meant I had to struggle through several months when my brain felt like it was wrapped in cotton and I could barely keep my eyes open.
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After sedating the man, a team of physicians at the Institute of Liver and Biliary Sciences Hospital in New Delhi was able to extract the worm by pulling it through his mouth with a pair of forceps.
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Oxycodone is a painkiller, Hydrocodone is also known as Vicodin, Diazepam is commonly called Valium, Temazepam treats anxiety or sleeplessness, Alprazolam is known as Xanax, and Doxylamine is a sedating antihistamine often used as a sleep aid.
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"If you're a starfish, and you're just going to lay in the bed, you don't need indicas," she said about the strain that's known for its physically sedating effects, pausing as the room erupts in cackling laughter.
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If the gum could deliver me from standard-issue horrors like those without any of the disorienting, sedating side-effects of Dramamine, could it also soothe the more existential varieties of unrest that come with everyday life?
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But court filings and depositions show that by the time of the W.H.O.'s decision, American corrections officials were more than a year into their consideration of midazolam for a new purpose: sedating condemned prisoners for execution.
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But Dr. Simon says that taking an extra Ativan or two would not cause slurring or serious impairment, especially for people who have been on the drug long-term and developed a tolerance to its sedating side effects.
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The elders dismissed their complaints or blamed them on "wild female imagination" — until it was discovered that men from the community had been creeping through windows at night, sedating whole households with bovine anesthetic and raping the women.
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This includes young children, but also young teens who arrive in the emergency department with some difficulty breathing and within hours needs to go to the pediatric intensive care unit for further care including IVs, sedating medications, antibiotics and breathing treatments.
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PDT Unfortunately, after news of Gill's lobster "sedating" methods began to circulate online, the Maine Health Inspection Program decided to investigate the restaurant's unorthodox practices, temporarily barring the sale of weeded-up lobsters, the Portland Press-Herald reported on Friday.
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While tracking and sedating a 3,000 pound rhino in order to embed the RFID chip and secure the ankle monitor is an arduous process, it appears to be a cost-effective and sustainable solution to catching poachers–but not for truly preventing poaching.
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"Typically, overdose deaths occur when the benzodiazepine is combined with another sedating medication, such as an opioid or alcohol," said Park, a professor at the Alpert Medical School at Brown University in Providence, Rhode Island, who was not involved in the study.
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The state of Arkansas contends that the attorneys' account of Jones's execution is inaccurate, saying that although the Arkansas Department of Correction officers did fail in their attempt to place an IV in Jones's neck, they were ultimately successful in sedating him.
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The same sedating effect that makes them useful for anxiety is what makes them some of the most dangerous things you can mix with alcohol, and if your psychiatrist prescribed you a benzo without making sure you understand that fact, then you should find a new one.
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It is short-acting, mildly sedating, noninvasive and has countless applications in the ER Children hold masks to their faces, grinning while having a major abscess drained; teens, while having a dislocated joint popped back into place; older patients while being "disimpacted" — treated for severe constipation.
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"Opioids act on the central nervous system and often have a sedating effect, so people may feel drowsier after taking opioids or may experience reduced motor functioning, which may cause them to lose their balance and become more at risk of falls," Saloner said by email.
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Other times, people who use cocaine might be doing it to offset the performance-impairing, sedating effects of alcohol—in other words, they want to keep their night going, suggests research by Stephen T. Higgins, director of the Center on Behavior and Health at the University of Vermont.
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Indicas [a type of cannabis strain which is typically more physically sedating compared to more stimulating sativas] can be a real outing-killer; they're better for when you just want to stay in for the night and chill and watch a movie, go to sleep early and get some rest.
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Over- the-counter sedating Antihistamines such as Doxylamine have sedating and anti- emetic effects and may provide short term relief but should only be used within advised dosages.
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Rupatadine is a non-sedating antihistamine. However, as in other non sedating second-generation antihistamines, the most common side effects in controlled clinical studies were somnolence, headaches and fatigue.
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In these studies, Ze339 was shown to be less sedating than cetirizine and fexofenadine.
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Tripelennamine is mildly sedating. Other side effects can include irritation, dry mouth, nausea, and dizziness.
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Non-sedating antihistamines that block histamine H1 receptors are the first line of therapy. First-generation antihistamines, such as diphenhydramine or hydroxyzine, block both brain and peripheral H1 receptors, and cause sedation. Second-generation antihistamines, such as loratadine, cetirizine or desloratadine, selectively antagonize peripheral H1 receptors, and are less sedating, less anticholinergic, and generally preferred over the first-generation antihistamines. Fexofenadine, a new-generation antihistamine that blocks histamine H1 receptors, may be less sedating than some second-generation antihistamines.
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They refuse decongestants, non-sedating antihistamines, even nonsteroidal anti-inflammatories for pain because they're afraid they'll be grounded.
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Setastine penetrates the blood-brain-barrier poorly so it is only mildly sedating compared to related molecules like diphenhydramine.
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Anxiety that would emerge in patients was countered with heavy doses of sedating drugs such as Sodium Amytal and Largactil.
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The sedating/narcotic effect of buprenorphine is increased by other sedating drugs such as other opioids, benzodiazepines, first generation antihistamines, alcohol, and antipsychotics. In addition, opioids and especially benzodiazepines increase the risk for potentially lethal respiratory depression. Strong inhibitors of the liver enzyme CYP3A4, such as ketoconazole, moderately increase buprenorphine concentrations; CYP3A4 inducers can theoretically decrease concentrations of buprenorphine.
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The effects of other sedating drugs and alcohol, as well as antihypertensives, can be increased. No relevant pharmacokinetic interactions have been described.
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Some studies show clonidine to be more sedating than guanfacine, which may be better at bed time along with an arousing stimulant at morning.
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The plant is also smoked during some important ceremonies to induce a euphoric and mild sedating effect. However, if not used properly, the plant can be very toxic.
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In an overdose, slow heart rate and low blood pressure are mainly due to imidazoline-1 receptor agonism. Dry mouth and sedating effects are due to alpha-2 agonism.
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Desipramine tends to be less sedating than other TCAs and tends to produce fewer anticholinergic effects such as dry mouth, constipation, urinary retention, blurred vision, and cognitive or memory impairments.
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Some, without evidence, have criticized the program as "giving up" on problem alcoholics by sedating them with alcohol, or that the free alcohol could attract individuals from outside the program area.
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Opioids: Opioid agents also work on the receptors in the central nervous system to relieve pain, induce sedation or drownsiness. However, it is more frequently used as a pain management therapy rather than a sedating agent and should not be discontinued even when sedating effect is achieved. Even though these sedating agents provide a comforting effect for the person, there are risks of substance abuse and diversion. Therefore, in order to both maintain the quality of care and prevent the risk of drug abuse, the Clinical Practice Guidelines for Quality Palliative Care from the National Consensus Project recommends a comprehensive assessment of symptoms prior to the initiation of pharmacological therapy, on- going monitor of both efficacy and toxicity of those agents alongside with personal and family education.
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Some variants of Nurofen contain additional active ingredients; for example, 'Nurofen Cold & Flu' contains the non-sedating decongestant pseudoephedrine. Others are advertised as being targeted for specific pain types, for example period pain.
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Eplivanserin is an inverse agonist on the serotonin receptor subtype 5-HT2A. In contrast to older sedating drugs acting on 5-HT2A receptors (e.g., mirtazapine, clozapine, risperidone), eplivanserin has practically no affinity to dopamine, histamine and adrenergic receptors.
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Promethazine is a first-generation antihistamine. It is used to treat allergies, trouble sleeping, and nausea. It may help with some symptoms associated with the common cold. It may also be used for sedating people who are agitated or anxious.
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In accordance, H1 receptor occupancy correlated well with subjective sleepiness for 30 mg hydroxyzine but there was no correlation for 10 or 20 mg cetirizine. As such, brain penetration and brain H1 receptor occupancy by cetirizine are dose- dependent, and in accordance, while cetirizine at doses of 5 to 10 mg have been reported to be non-sedating or mildly sedating, a higher dose of 20 mg has been found to induce significant drowsiness in other studies. Cetirizine has been shown to inhibit eosinophil chemotaxis and LTB4 release. At a dosage of 20 mg, Boone et al.
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Patients with respiratory arrest can be intubated without drugs. However, patients can be given sedating and paralytic drugs to minimize discomfort and help out with intubation. Pretreatment includes 100% oxygen, lidocaine, and atropine. 100% oxygen should be administered for 3 to 5 minutes.
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He arms himself with twin handguns that fire hypodermic projectiles containing dangerous narcotics. The projectiles were tailored to pierce body armor. He developed a sedating truth serum for use as an investigator. He created androids, including the sentient and superhuman android, Volton.
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MDMA is a stimulating psychedelic. Although it is not sedating like other date rape drugs, it has been used to facilitate sexual assault. It is empathogenic and can increase disinhibition and sexual desire. Often Ecstasy is combined with amphetamines or other drugs.
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Meanwhile, Barb reunites with her estranged mother Nancy, and sister Cindy, on the occasion of Nancy's remarriage. Adaleen realizes Alby has been sedating Roman, and brings Roman to Bill's home seeking safety. Barb and Margie confess to neighbor Pam that they are polygamists.
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Periciazine is a rather sedating and anticholinergic antipsychotic, and despite being classed with the typical antipsychotics, its risk of extrapyramidal side effects is comparatively low. It has a relatively high risk of causing hyperprolactinaemia and a moderate risk of causing weight gain and orthostatic hypotension.
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Mizolastine (Mizollen) is a once-daily, non-sedating antihistamine. It blocks H1 receptors and is commonly fast-acting. It does not prevent the actual release of histamine from mast cells, it just prevents it binding to receptors. Side effects can include dry mouth and throat.
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More serious side effects may include suicide, mania, irregular heart rate, and pathologically prolonged erections. It is unclear if use during pregnancy or breastfeeding is safe. It is a phenylpiperazine compound of the serotonin antagonist and reuptake inhibitor (SARI) class. Trazodone also has sedating effects.
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Other techniques aim at "tonifying" () or "sedating" () qi. The former techniques are used in deficiency patterns, the latter in excess patterns. De qi is more important in Chinese acupuncture, while Western and Japanese patients may not consider it a necessary part of the treatment.
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Prazitone (AGN-511) is a barbiturate derivative developed in the 1970s.DE Patent 1645911 Unlike most barbiturates, it has little or no sedative effects, instead acting as a non-sedating anxiolytic and antidepressant.Ross Langlands. Method for imparting anti-depressant and/or anxiolytic effects to animals.
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Mebicar purportedly has anti-anxiety (anxiolytic) properties. It is also used to aid smoking cessation. In addition, mebicar may be useful in the treatment of ADHD symptoms. In contrast with typical anxiolytic medications such as benzodiazepines, mebicar is non- habit forming, non-sedating and does not impair motor function.
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Types of cannabis CBD is a 5-HT1A receptor agonist, which is under laboratory research to determine if it has an anxiolytic effect. It is often claimed that sativa strains provide a more stimulating psychoactive high while indica strains are more sedating with a body high. However, this is disputed by researchers.
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As a "non-sedating" antihistamine, loratadine causes less (but still significant, in some cases) sedation and psychomotor retardation than the older antihistamines because it penetrates the blood/brain barrier to a smaller extent. Other possible side effects include headache and antimuscarinic effects such as urinary retention, dry mouth, blurred vision, and gastrointestinal problems.
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Noscapine can increase the effects of centrally sedating substances such as alcohol and hypnotics. The drug should not be taken with any MAOIs (monoamine oxidase inhibitors), as unknown and potentially fatal effects may occur. Noscapine should not be taken in conjunction with warfarin as the anticoagulant effects of warfarin may be increased.
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In the mid-1940s, Frank Berger was working in a laboratory of a British drug company, looking for a preservative for penicillin, when he noticed that a compound called mephenesin calmed laboratory rodents without actually sedating them. Berger subsequently referred to this sedating or “tranquilizing” effect in a now-historic article, published by the British Journal of Pharmacology in 1946. However, three major drawbacks existed to the use of mephenesin as a tranquilizer: a very short duration of action, greater effect on the spinal cord than on the brain, and a weak activity. In May 1950, after moving to Carter Products in New Jersey, Berger and a chemist, Bernard John Ludwig, synthesized a chemically related tranquilizing compound, meprobamate, that overcame these three drawbacks.
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It has been proposed as a possible candidate for a novel non- sedating anxiolytic or anticonvulsant drug for use in humans The sponsor registered a clinical trial in ClinicalTrials.gov for the treatment of anxiety associated with panic disorder but the results have not been reported. It was developed by Arzneimittelwerk Dresden in the 1990s.
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Treatments for alcoholism aim to end ethanol consumption and provide social support to prevent relapse. In some cases, sedating medications (benzodiazepines) may be necessary to prevent and/or reduce withdrawal symptoms. These benzodiazepines are only prescribed for a short period time to aid with withdrawal symptoms, for they too can become addictive.Blondell R.D. (February 2005).
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Higher concentrations are found in the skin than in the plasma. Cetirizine, although less sedating, is non- dialyzable and possesses similar antihistamine properties. The other metabolites identified include a N-dealkylated metabolite, and an O-dealkylated 1/16 metabolite with a plasma half-life of 59 hours. These pathways are mediated principally by CYP3A4 and CYP3A5.
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The principal effects of methadone maintenance are to relieve narcotic craving, suppress the abstinence syndrome, and block the euphoric effects associated with opiates. Methadone maintenance is medically safe and non-sedating. It is also indicated for pregnant women addicted to opiates. For individuals who wish to completely move away from drugs, they can start a methadone reduction program.
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It also thus comes with more risks in this vulnerable population. Buprenorphine/naloxone may be recommended for socially stable opioid users who may not be able to retrieve medications from a center daily, who may have another condition requiring regular primary care visits, or who may have jobs or daily lives that require they maintain all their faculties and cannot take a sedating medication. Buprenorphine/naloxone is also recommended over methadone in people who may be at high risk of methadone toxicity, such as the elderly, those taking high doses of benzodiazepines or other sedating drugs, concomitant alcohol abusers, those with a lower level of opioid tolerance, and those at high risk of prolonged QT interval. It is also helpful to use the medication in combination with psychosocial support and counseling for the person.
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Instead of sedating some patients, midazolam can make them violent. Dennis McGuire took 25 minutes to die; he gasped and snorted. The U.S. Supreme Court has ruled that if the first drug does not make the inmate unconscious there is an unacceptable risk of suffocation and pain from the two following drugs. Potassium chloride causes severe pain if used without an anesthetic.
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The psychologist isn't interested in sedating Niki further, and believes she can help Niki. Niki is visited by D. L., who used his powers to enter her room and proposes breaking her out. D. L. states that he is having trouble raising Micah alone, but Niki is still resigned to her fate. After Niki gives him a bit of advice, D. L. leaves.
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The monotonous Country Vigilance scenario has been demonstrated to be sensitive to detect the effects of fatigue or sleepiness on driving performance. This scenario has been useful in evaluating patients with a variety of conditions including Obstructive Sleep Apnea (OSA), measuring the effects of sleep deprivation, chronic primary insomnia, and is sensitive to CNS depressants (e.g., alcohol and sedating antihistamines).
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J entry in PiHKAL BDB produces entactogenic, MDMA-like effects. Although pleasant and euphoric, BDB is also fairly sedating and some users feel that the lack of stimulant effect makes it less enjoyable than other similar drugs. Additional side effects associated with BDB include nystagmus and dizziness. Very little data exists about the pharmacological properties, metabolism, and toxicity of BDB.
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Reducing mosquito breeding areas (e.g. eliminating standing water pools, stocking ponds with fish that consume mosquito larva) and the use of other mosquito control methods such as insecticides, mosquito traps, protective clothing, bed nets, and repellants (e.g. DEET or permethrin) are effective, highly recommended means for reducing mosquito bites. Daily doses of a non-sedating second-generation anti-histamines (e.g.
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Known symptoms of crooked cow disease include athrogryposis (permanently flexed joints), torticollis (twisting of the neck), scoliosis (curving of the spine), kyphosis (humpback), and cleft plate. It is thought that teratogenic alkaloids like anagyrine cause the deformities by sedating the fetus, causing it to remain fixed in an abnormal position as it grows."AAHP Field Disease Investigation Unit (FDIU)." Crooked Calf.
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With the help of Kerim, they board the Orient Express and depart for Trieste and the Italian frontier. As a part of Kronsteen's strategy, the SMERSH/SPECTRE assassin Donovan 'Red' Grant kills Kerim. Bond contacts Grant, who is pretending to be an agent named Nash. After sedating Romanova, Nash reveals his identity to Bond, who then fights Grant in their train compartment.
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Heather returns home for Dylan's stuffed Tyrannosaurus while his babysitter Julie tries unsuccessfully to keep the nurses from sedating the sleep-deprived boy. Dylan falls asleep from the sedative. Freddy brutally kills Julie in Dylan's dream. Capable of sleepwalking, Dylan leaves the hospital of his own accord while Heather chases him home across the interstate as Freddy taunts and dangles him before traffic.
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Bailey claimed to have learnt DST from > psychiatrists in Britain and Europe, though it was later found that only a > mild variant was used there, sedating traumatised ex-soldiers for a few > hours at a time, not the median 14 days under which Bailey and his colleague > Dr John Herron subjected their 1,127 DST patients at Chelmsford between 1963 > and 1979.
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The International Air Transport Association regulations do not recommend sedating or tranquillising pets during shipment as it can increase the risk of breathing and vascular problems. Sedation remains the main cause of death whilst shipping an animal as the effect that the drug has upon the animal is uncertain and cannot be predicted before travel. Airlines no longer accept sedated pets on board their aircraft.
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SL651498 has been suggested for development as a novel non-sedating anxiolytic drug for humans, although it is still only at an early stage of research. Preliminary human trials suggest similar efficacy to lorazepam as an anxiolytic, but with little or no sedation or impairment of memory, motor skills or cognitive function. There are other possibly anxioselective compounds in development, such as L-838,417, NGD 91-3.
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Cannabis is paradoxical in that it simultaneously produces stimulating, sedating and mildly psychedelic properties and both anxiolytic or anxiogenic properties, depending on the individual and circumstances of use. Depressant properties are more obvious in occasional users, and stimulating properties are more common in chronic users. Khantzian noted that research had not sufficiently addressed a theoretical mechanism for cannabis, and therefore did not include it in the SMH.
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Protease inhibitors, nefazodone, sertraline, grapefruit, fluoxetine, erythromycin, diltiazem, clarithromycin inhibit the metabolism of midazolam, leading to a prolonged action. St John's wort, rifapentine, rifampin, rifabutin, phenytoin enhance the metabolism of midazolam leading to a reduced action. Sedating antidepressants, antiepileptic drugs such as phenobarbital, phenytoin and carbamazepine, sedative antihistamines, opioids, antipsychotics and alcohol enhance the sedative effects of midazolam. Midazolam is metabolized almost completely by cytochrome P450-3A4.
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Some evidence indicates the medicinal effects of plants including N. caerulea that contain the psychoactive alkaloid aporphine were known to both the Maya and the Ancient Egyptians. The mildly sedating effects of N. caerulea makes it a likely candidate (among several) for the lotus plant eaten by the mythical Lotophagi in Homer's Odyssey. This lotus has been used to produce perfumes since ancient times; it is also used in aromatherapy.
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All-night bright-light suppression of melatonin suppressed the normal trough of body temperature seen between 3-4 a.m., the time of maximum melatonin levels. Exogenous infusion of melatonin, replicating endogenous levels, in the bright light condition (in which endogenous melatonin was suppressed) reestablished the normal trough of core body temperature. Melatonin's psychoactive effects were only sedating, however, leading him to focus on DMT in his future work.
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96 seka (Kosrae), and malok or malogu (parts of Vanuatu). Kava is consumed for its sedating effects throughout the Pacific Ocean cultures of Polynesia, including Hawaii, Vanuatu, Melanesia, and some parts of Micronesia such as Palau. To a lesser extent, it is consumed in nations where it is exported as an herbal medicine. The root of the plant is used to produce a drink with sedative, anesthetic, and euphoriant properties.
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Nitrogen narcosis is also called “L’ivresse des grandes profondeurs” or "rapture of the deep". Nitrogen comprises 79% of the air, but at surface pressures it has no sedating effect. At greater depths, however, nitrogen affects the brain in the same way as nitrous oxide (also known as laughing gas) and other anaesthetic gases. The effect is similar to the effects of alcohol, and to some extent there is cross-tolerance.
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Gillies based his work on methods that had been developed previously, but were never intended for such drastic application. He improved upon these efforts and, when combined with anaesthesia and sedating medication, found his techniques rapidly gaining in popularity. The call for doctors able to perform facial reconstruction grew rapidly and received national attention. Dr. Varaztad Kazanjian became the first recognized post- war plastic surgery specialist at Harvard Medical School.
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Combining a muscle relaxant like carisoprodol with opioids and benzodiazepines is referred to as "The Holy Trinity" as it has been reported to increase the power of the "high". Recreational users of carisoprodol usually seek its potentially heavy sedating, relaxant, and anxiolytic effects. Also, because of its potentiating effects on narcotics, it is often abused in conjunction with many opioid drugs. Also it is not detected on standard drug testing screens.
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Pheniramine (trade name Avil among others) is an antihistamine with anticholinergic properties used to treat allergic conditions such as hay fever or urticaria. It has relatively strong sedative effects, and may sometimes be used off-label as an over-the-counter sleeping pill in a similar manner to other sedating antihistamines such as diphenhydramine. Pheniramine is also commonly found in eyedrops used for the treatment of allergic conjunctivitis. It was patented in 1948.
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Panadol night is a GlaxoSmithKline painkiller intended for use at night. It consists of 500 milligrams of paracetamol, 25 milligrams of diphenhydramine hydrochloride (a sedating antihistamine) and other "non-hazardous ingredients"PANADOL NIGHT TABLETS Safety Data Sheet , SDS Number 109998, GlaxoSmithKline, Approved/Revised 08-Dec-2006 It is sold in Australia, Cyprus United Kingdom, Ireland, New Zealand and the Middle East. It became available as an over the counter medication in the UK in 1996.
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People who do not respond to the maximum dose of H1 antihistamines may benefit from increasing the dose, then to switching to another non-sedating antihistamine, then to adding a leukotriene antagonist, then to using an older antihistamine, then to using systemic steroids and finally to using ciclosporin or omalizumab. H2-receptor antagonists are sometimes used in addition to H1-antagonists to treat urticaria, but there is limited evidence for their efficacy.
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Perphenazine has sedating and anxiolytic properties, making the drug useful for the treatment of agitated psychotic patients. A valuable off-label indication is the short-time treatment of hyperemesis gravidarum, in which pregnant women experience violent nausea and vomiting. This problem can become severe enough to endanger the pregnancy. As perphenazine has not been shown to be teratogenic and works very well, it is sometimes given orally in the smallest possible dose.
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There is also insufficient evidence to determine effectiveness in those with depression complicated by dementia. Any antidepressant can cause low blood sodium levels; nevertheless, it has been reported more often with SSRIs. It is not uncommon for SSRIs to cause or worsen insomnia; the sedating atypical antidepressant mirtazapine can be used in such cases. Irreversible monoamine oxidase inhibitors, an older class of antidepressants, have been plagued by potentially life-threatening dietary and drug interactions.
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Certain second-generation antipsychotics are misused or abused for their sedative, tranquilizing, and (paradoxically) "hallucinogenic" effects. The most commonly second-generation antipsychotic implicated is quetiapine. In case reports, quetiapine has been abused in doses taken by mouth (which is how the drug is available from the manufacturer), but also crushed and insufflated or mixed with water for injection into a vein. Olanzapine, another sedating second-generation antipsychotic, has also been misused for similar reasons.
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Intravenous corticosteroids and methylxanthines are often given. If the person with a severe asthma exacerbation is on a mechanical ventilator, certain sedating medications such as ketamine or propofol, have bronchodilating properties. According to a new randomized control trial ketamineand aminophylline are also effective in children with acute asthma who responds poorly to standard therapy. Status asthmaticus is slightly more common in males and is more common among people of African and Hispanic origin.
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When Steve realizes what really happened, he returns, punches Alan, and threatens a lawsuit. Alan ends the day early and sends his staff and patients home, including Sarah, a teenager who wants to have her braces removed. Later that night, Brooke meets Alan at a new opera-themed room at his practice. After sedating her under the premise of cleaning her teeth, he pulls out her teeth and cuts off her tongue.
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Rupatadine is a second generation, non-sedating, long-acting histamine antagonist with selective peripheral H1 receptor antagonist activity. It further blocks the receptors of the platelet-activating factor (PAF) according to in vitro and in vivo studies. Rupatadine possesses anti- allergic properties such as the inhibition of the degranulation of mast cells induced by immunological and non-immunological stimuli, and inhibition of the release of cytokines, particularly of the tumor necrosis factors (TNF) in human mast cells and monocytes.
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He explains that a venomous snake, the krait, has crawled onto his stomach, underneath the covers, and asks Timber to fetch a doctor. Timber calls Dr. Ganderbai, a local Indian doctor who rushes over as soon as possible. Timber and Ganderbai frantically try to get the snake off of Harry through various methods (which include sedating the snake and giving Harry an antivenin). As the story progresses, it is revealed that there is in fact no snake on Harry.
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As an alternative to taking prescription drugs, some evidence shows that an average person seeking short-term help may find relief by taking over-the-counter antihistamines such as diphenhydramine or doxylamine. Diphenhydramine and doxylamine are widely used in nonprescription sleep aids. They are the most effective over-the-counter sedatives currently available, at least in much of Europe, Canada, Australia, and the United States, and are more sedating than some prescription hypnotics.DrugBank: DB00366 (Doxylamine) . Drugbank.ca.
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The principal goals of methadone maintenance are to relieve opioid cravings, suppress the abstinence syndrome, and block the euphoric effects associated with opioids. Chronic methadone dosing will eventually lead to neuroadaptation, characterised by a syndrome of tolerance and withdrawal (dependence). However, when used correctly in treatment, maintenance therapy has been found to be medically safe, non-sedating, and can provide a slow recovery from opioid addiction. Methadone has been widely used for pregnant women addicted to opioids.
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Other sleep remedies that may be considered "sedative-hypnotics" exist; psychiatrists will sometimes prescribe medicines off-label if they have sedating effects. Examples of these include mirtazapine (an antidepressant), clonidine (generally prescribed to regulate blood pressure), quetiapine (an antipsychotic), and the over-the-counter sleep aid diphenhydramine (Benadryl – an antihistamine). Off-label sleep remedies are particularly useful when first-line treatment is unsuccessful or deemed unsafe (for example, in patients with a history of substance abuse).
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Hydroxyzine exhibits anxiolytic and sedative properties in many psychiatric patients. Other studies have suggested that hydroxyzine acts as an acute hypnotic, reducing sleep onset latency and increasing sleep duration — also showing that some drowsiness did occur. This was observed more in female patients, who also had greater hypnotic response. The use of sedating drugs alongside hydroxyzine can cause oversedation and confusion if administered in large amounts—any form of treatment alongside sedatives should be done under supervision of a doctor.
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Both alcohol and the antihistamine cetirizine impaired performance in the test measures, and their effects were additive. The non- sedating antihistamine loratadine had no effect on any of the measures studied. The arrow version of the flanker test has also been evaluated as a method of detecting impairment due to alcohol and drugs in drivers at the roadside, demonstrating the importance of selective attention skills to spatial abilities such as vehicle operation. Various psychiatric and neurological conditions also affect performance on flanker tasks.
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Nevins, 531–533 Under the guise of a vacation cruise, Cleveland and his surgeon, Dr. Joseph Bryant, left for New York. The surgeons operated aboard the Oneida, a yacht owned by Cleveland's friend E. C. Benedict, as it sailed off Long Island.Nevins, 529 The surgery was conducted through the President's mouth, to avoid any scars or other signs of surgery.Nevins, 530–531 The team, sedating Cleveland with nitrous oxide and ether, successfully removed parts of his upper left jaw and hard palate.
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Short to intermediate-acting benzodiazepines are preferred in the elderly such as oxazepam and temazepam. The high potency benzodiazepines alprazolam and triazolam and long-acting benzodiazepines are not recommended in the elderly due to increased adverse effects. Nonbenzodiazepines such as zaleplon and zolpidem and low doses of sedating antidepressants are sometimes used as alternatives to benzodiazepines. Long- term use of benzodiazepines is associated with increased risk of cognitive impairment and dementia, and reduction in prescribing levels is likely to reduce dementia risk.
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In clinical trials, the drug has shown to provide a sustained nootropic and anxiolytic effect which is useful for the treatment of generalized anxiety disorder (GAD). Selank has an advantage over traditional anxiety treatments, such as benzodiazepines, as it has no sedating or negative cognitive side effects and no associated addiction or withdrawal problems. Selank is closely related to another nootropic drug, Semax, also developed by the Institute of Molecular Genetics in Russia. This drug is currently available in Russian and Ukrainian pharmacies.
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Reducing the types of movements that trigger or worsen dystonic symptoms provides some relief, as does reducing stress, getting plenty of rest, moderate exercise, and relaxation techniques. Various treatments focus on sedating brain functions or blocking nerve communications with the muscles via drugs, neuro-suppression, or denervation. All current treatments have negative side-effects and risks. A geste antagoniste is a physical gesture or position (such as touching one's chin) that temporarily interrupts dystonia, it is also known as a sensory trick.
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Recently, Broward General Medical Center received the Joint Commission's Ernest Amory Codman Award, which recognizes "excellence in the use of outcomes measurement to achieve improvements in the quality and safety of health care". Broward General received the award for producing better outcomes related to sedating children for diagnostic and therapeutic procedures. The process reduced the failed sedation rate by 98 percent by using a more effective sedative and initiating a standard protocol to reduce failed sedation, in addition to creating a soothing atmosphere for children.
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Blood pressure, pulse, respiratory rate, and Glasgow Coma Scale are monitored frequently. Once the diagnosis is confirmed, admission to an intensive care unit may be preferable, especially since 15 percent may have further bleeding soon after admission. Nutrition is an early priority, mouth or nasogastric tube feeding being preferable over parenteral routes. In general, pain control is restricted to less-sedating agents such as codeine, as sedation may impact on the mental status and thus interfere with the ability to monitor the level of consciousness.
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If sexual dysfunction is present prior to the onset of depression, SSRIs should be avoided. Another popular option is to switch to the atypical antidepressant bupropion (Wellbutrin) or to add bupropion to the existing therapy; this strategy is possibly more effective. It is not uncommon for SSRIs to cause or worsen insomnia; the sedating noradrenergic and specific serotonergic antidepressant (NaSSA) antidepressant mirtazapine (Zispin, Remeron) can be used in such cases. Cognitive Behavioral Therapy for Insomnia can also help to alleviate the insomnia without additional medication.
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Procedural sedation and analgesia (PSA) is a technique in which a sedating/dissociative medication is given, usually along with an analgesic medication, in order to perform non-surgical procedures on a patient. The overall goal is to induce a decreased level of consciousness while maintaining the patient's ability to breathe on their own. Airway protective reflexes are not compromised by this process Walls, Ron M., MD; Hockberger, Robert S., MD; Gausche-Hill, Marianne, MD, FACEP, FAAP, FAEMS (2018). Rosen's Emergency Medicine: Concepts and Clinical Practice.
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Although it was marketed as being safer, meprobamate has most of the pharmacological effects and dangers of the barbiturates and acts at the barbiturate binding site (though it is less sedating at effective doses). It is reported to have some anticonvulsant properties against absence seizures, but can exacerbate generalized tonic-clonic seizures. Meprobamate's mechanism of action is not completely known. It has been shown in animal studies to have effects at multiple sites in the central nervous system, including the thalamus and limbic system.
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Despite this, Bond elects not to leave the train for a plane or the consulate, after having fallen for Romanova and not wanting to cut their time short. Grant pretends to be Nash, an MI6 agent sent by M in response to the death of Kerim. After sedating Romanova, under the guise of standing guard over Bond, he waits until they are both asleep, and plans to murder them. However, due to his vanity, he taunts Bond, revealing details of a meeting with Rosa Klebb.
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However, these antihistamines may cause extreme drowsiness, therefore, people are advised to not operate heavy machinery or drive while taking this kind of medication. Other side effects include dry mouth, blurred vision, constipation, difficulty with urination, confusion, and light-headedness. There is also a newer second generation of antihistamines that are generally classified as the "non- sedating antihistamines" or anti-drowsy, which include cetirizine, loratadine, and fexofenadine. An example of nasal decongestants is pseudoephedrine and its side-effects include insomnia, restlessness, and difficulty urinating.
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The first reported evidence of stimulant medication used to treat children with concentration and hyperactivity problems came in 1937. Charles Bradley in Providence, Rhode Island reported that a group of children with behavioral problems improved after being treated with the stimulant Benzedrine. In 1954, the stimulant methylphenidate (Ritalin, which was first produced in 1944) became available; it remains one of the most widely prescribed medications for ADHD. Initially the drug was used to treat narcolepsy, chronic fatigue, depression, and to counter the sedating effects of other medications.
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The newer class of second-generation H1 antihistamines do not readily permeate the blood–brain barrier and thus are less likely to cause sedation, although individual reactions, concomitant medications and dosage may increase the likelihood of a sedating effect. In contrast, histamine H3 receptor antagonists increase wakefulness. Similar to the sedative effect of first- generation H1 antihistamines, an inability to maintain vigilance can occur from the inhibition of histamine biosynthesis or the loss (i.e., degeneration or destruction) of histamine-releasing neurons in the TMN.
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On the other hand, second generation antihistamines do not cross the blood-brain barrier, thus eliminating sedating effects. Currently, there is a lack of association between prenatal antihistamine exposure and birth defects. Antihistamines during pregnancy have not been linked to birth defects; however, further research is necessary for some antihistamine medications to determine safety during pregnancy. It is suggested that women speak to their healthcare professionals before taking any over-the-counter or prescription medication while pregnant to ensure that there are no adverse health outcomes.
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Before inserting the probe, mild to moderate sedation is induced in the patient to ease the discomfort and to decrease the gag reflex, thus making the ultrasound probe easier to pass into the esophagus. Mild or moderate sedation can be induced with medications such as midazolam (a benzodiazepine with sedating, amnesiac qualities), fentanyl (an opioid), or propofol (a sedative/general anesthetic, depending on dosage). Usually a local anesthetic spray is used for the back of the throat, such a xylocaine and/or a jelly/lubricant anesthetic for the esophagus. Children are anesthetized.
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The top line represents the number of benzodiazepine deaths that also involved opioids in the US. The bottom line represents benzodiazepine deaths that did not involve opioids. Benzodiazepines have a wide therapeutic index and taken alone in overdose rarely cause severe complications or fatalities. More often than not, a patient who inadvertently takes more than the prescribed dose will simply feel drowsy and fall asleep for a few hours. Benzodiazepines taken in overdose in combination with alcohol, barbiturates, opioids, tricyclic antidepressants, or sedating antipsychotics, anticonvulsants, or antihistamines are particularly dangerous.
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Usually, sports psychiatrists choose non-sedating medications because they are less likely to cause side effects such as an increase in weight and body fat, sedentary behavior, a decrease in insulin sensitivity, cardiac issues. The effect on athletes' performance must also be taken into consideration, as well the anti-doping guidelines of different sports leagues. The World Anti-Doping Agency (WADA) provides a list of generally banned substances, and it is left to each leagues' discretion to add a more strict code. Widely used medications include antidepressants (e.g.
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In May 1137, Prior Robert of Shrewsbury Abbey is determined that the Abbey must have the relics of a saint. Finding no suitable local saint, Robert finds one in nearby Wales. Brother Cadfael has two novices assisting him in his herb and vegetable gardens: John (practical, down-to- earth, whose vocation Cadfael doubts) and the ambitious Columbanus (of whose illness Cadfael is sceptical, although he treats him with sedating poppy syrup). Columbanus and Brother Jerome, Robert's clerk, go to Saint Winifred's Well in North Wales for a cure.
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The first synthetic antimicrobial drug, arsphenamine, discovered in 1909 by Sahachiro Hata in the laboratory of Paul Ehrlich, is not toxic to bacteria until it has been converted to an active form by the body. Likewise, prontosil, the first sulfa drug (discovered by Gerhard Domagk in 1932), must be cleaved in the body to release the active molecule, sulfanilamide. Since that time, many other examples have been identified. Terfenadine, the first non-sedating antihistamine, had to be withdrawn from the market because of the small risk of a serious side effect.
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However, terfenadine was discovered to be the prodrug of the active molecule, fexofenadine, which does not carry the same risks as the parent compound. Therefore, fexofenadine could be placed on the market as a safe replacement for the original drug. Loratadine, another non-sedating antihistamine, is the prodrug of desloratadine, which is largely responsible for the antihistaminergic effects of the parent compound. However, in this case the parent compound does not have the side effects associated with terfenadine, and so both loratadine and its active metabolite, desloratadine, are currently marketed.
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Map of the prison US Military Police officer restraining and sedating a prisoner, while a soldier holds him down From 2003 until August 2006, Abu Ghraib prison was used for detention purposes by both the U.S.-led coalition occupying Iraq and the Iraqi government. The Iraqi government has controlled the area of the facility known as "The Hard Site". The prison was used to house only convicted criminals. Suspected criminals, insurgents or those arrested and awaiting trial were held at other facilities, commonly known as "camps" in U.S. military parlance.
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Bipolar patients taking antipsychotics have lower scores on tests of memory and full-scale IQ than patients taking other mood stabilisers. Use of both typical and atypical antipsychotics is associated with risk of cognitive impairment, but the risk is higher for antipsychotics with more sedating effects. Among bipolar patients taking anticonvulsants, those on lamotrigine have a better cognitive profile than those on carbamazepine, valproate, topiramate, and zonisamide. Although decreased verbal memory and slowed psychomotor speed are common side effects of lithium use these side effects usually disappear after discontinuation of lithium.
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Doxylamine succinate is a potent anticholinergic and has a side-effect profile common to such drugs, including dry mouth, ataxia, urinary retention, drowsiness, memory problems, inability to concentrate, hallucinations, psychosis, and a marked increased sensitivity to external stimuli. Like many hypnotics, it should not be combined with other antihistamines, such as cetirizine (Zyrtec) or diphenhydramine (Benadryl), as this combination can increase the risk of serious side effects. Some people can have a different reaction: instead of sedating, it stimulates. Using doxylamine over a long period of time is not recommended.
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Taking the name Annihilus, he set out to not only right those who wronged him, but to ensure that no one should ever harm him again. While Annihilus forcibly took control of his immediate sector of space, a king rose to prominence on Baluur. Blastaar was a ruthless and powerful leader who sought to expand Baluurian domain. The other Baluurians feared him and were eventually able to depose him by sedating him heavily and sending him to what they hoped would be his destruction in the center of the Negative Zone.
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Before he can, however, a captive Jack Russell Terrier bites him in the crotch, causing him to fire a shot in the air. After hearing the gunshot, Ted drives the car through the door and runs it into a cart, launching numerous syringes into Dr. Varnick and sedating him. As the Newtons reunite with Beethoven and free all the captive dogs, they notice Harvey and Vernon trying to escape and send the dogs after them. They escape into a junkyard, only to be attacked by a pack of Dobermans guarding it.
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Acrivastine is a medication used for the treatment of allergies and hay fever. It is a second-generation H1-receptor antagonist antihistamine (like its base molecule triprolidine) and works by blocking histamine H1 receptors. This non- sedating antihistamine is sold under the brand name Benadryl Allergy Relief in the United Kingdom by McNeil Laboratories. It should not be confused with Benadryl Once a Day which has cetirizine as the active ingredient and is also sold by McNeil in the UK, nor with the American Benadryl, which uses diphenhydramine as its active ingredient.
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Ryu and Ken break Balrog and Honda out of confinement and rush to confront Bison, who is fighting Chun- Li, but Bison escapes and releases sleeping gas, sedating them all. Guile plans his assault on Bison's base. He is impeded by the Deputy Secretary of the A.N., who informs Guile that the decision has been made to pay Bison the ransom, but Guile and his loyal troops nevertheless proceed with the mission. At the base, Dhalsim is found out by a security guard; during the ensuing fight, Charlie is released, and he kills the guard to protect Dhalsim.
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On 6 November 1941, minutes before the expected arrival of the Gestapo at their house in Berlin- Grunewald, Gottschalk and his wife committed suicide by gas poisoning after sedating their son, who died with them. They are buried at the Stahnsdorf South-Western Cemetery. Though warned by Minister Goebbels, Brigitte Horney and Wolfgang Liebeneiner, as well as other artists like Gustav Knuth, Hans Brausewetter, Werner Hinz, and Ruth Hellberg attended the funeral. Goebbels ordered no further mentions of Gottschalk in the German newspapers, but word got out anyway and millions of German women mourned his death.
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This may explain why patients commonly increase doses over time and many eventually take more than one type of benzodiazepine after the first loses effectiveness. Additionally, because tolerance to benzodiazepine sedating effects develops more quickly than does tolerance to brainstem depressant effects, those taking more benzodiazepines to achieve desired effects may suffer sudden respiratory depression, hypotension or death. Most patients with anxiety disorders and PTSD have symptoms that persist for at least several months, making tolerance to therapeutic effects a distinct problem for them and necessitating the need for more effective long-term treatment (e.g., psychotherapy, serotonergic antidepressants).
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Cannabis use is associated with comorbid mental health problems, such as mood and anxiety disorders, and discontinuing cannabis use is difficult for some users. Psychiatric comorbidities are often present in dependent cannabis users including a range of personality disorders. Based on annual survey data, some high school seniors who report smoking daily (nearly 7%, according to one study) may function at a lower rate in school than students that do not. The sedating and anxiolytic properties of tetrahydrocannabinol (THC) in some users might make the use of cannabis an attempt to self-medicate personality or psychiatric disorders.
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There is a small risk associated with sedating children to facilitate a clear MRI. The age when CP is diagnosed is important, but medical professionals disagree over the best age to make the diagnosis. The earlier CP is diagnosed correctly, the better the opportunities are to provide the child with physical and educational help, but there might be a greater chance of confusing CP with another problem, especially if the child is 18 months of age or younger. Infants may have temporary problems with muscle tone or control that can be confused with CP, which is permanent.
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At higher doses, it may result in slurred speech, staggering gait, poor judgment, and slow, uncertain reflexes. Doses of sedatives such as benzodiazepines, when used as a hypnotic to induce sleep, tend to be higher than amounts used to relieve anxiety, whereas only low doses are needed to provide a peaceful effect. Sedatives can be misused to produce an overly- calming effect (alcohol being the classic and most common sedating drug). In the event of an overdose or if combined with another sedative, many of these drugs can cause deep unconsciousness (see hypnotic) and even death.
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Some gases have other dangerous effects when breathed at pressure; for example, high-pressure oxygen can lead to oxygen toxicity. Although helium is the least intoxicating of the breathing gases, at greater depths it can cause high pressure nervous syndrome, a still mysterious but apparently unrelated phenomenon. Inert gas narcosis is only one factor influencing the choice of gas mixture; the risks of decompression sickness and oxygen toxicity, cost, and other factors are also important. Because of similar and additive effects, divers should avoid sedating medications and drugs, such as cannabis and alcohol before any dive.
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Trey blames himself for the loss of Kaneda, and psychiatrist Searle assesses him as a suicide risk, sedating him. Icarus II docks with Icarus I. Capa, Searle, Mace, and former communications officer now-Captain Harvey search the vessel, leaving Cassie and botanist Corazon on board Icarus II. They discover Icarus Is mainframe has been sabotaged, making its bomb delivery impossible. In the ship's log is a rambling message from Captain Pinbacker, who abandoned his mission. The crew of Icarus I is found charred to death in the solar observation room, where they were long ago exposed to the unshielded Sun.
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In the second statement, she alleged that between July and October 1984, Bamber had said he wished he could "get rid of them all". He had talked disparagingly about his "old" father and "mad" mother, she said, who were trying to "run his life". He said his sister had nothing to live for, and that the twins were disturbed. That his parents were paying for Sheila's expensive flat in Maida Vale annoyed him, she said.. In discussions she said she had dismissed as "idle talk", Bamber had talked about sedating his parents with sleeping pills, shooting them, then setting fire to the farmhouse.
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More recently, a range of non-sedating anxiolytic drugs derived from the same structural families as the Z-drugs have been developed, such as alpidem (Ananyxl) and pagoclone, and approved for clinical prescription. Nonbenzodiazepine drugs are much more selective than the older benzodiazepine anxiolytics, producing effective relief of anxiety/panic with little or no sedation, anterograde amnesia, or anticonvulsant effects, and are thus potentially more precise than older, anti-anxiety drugs. However, anxiolytic nonbenzodiazepines are not widely prescribed and many have collapsed after initial clinical trials and consumption halted many projects, including but not limited to alpidem, indiplon, and suriclone.
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The sugar apple is an effective trick, successfully sedating Sportacus and giving Robbie and his team a chance to put him in a portable cage. Robbie's three teammates relocate the trapped Sportacus to Robbie's underground headquarters while Robbie stays on the surface to set up a cannon, revealed in the full episode to be the way Robbie intends to run Sportacus out of town. His plans are thwarted when Stephanie and Stingy open the base's periscope and use its cylindrical interior as a means of transporting a real apple to Sportacus. The apple rolls towards the cage undetected by the now- sleeping Bobbie, Tobbie, and Flobbie.
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Its lack of sedating properties relative to phenobarbital and lack of somatic effects relative to phenytoin generated much interest. Within two years, primidone was no longer seen as the drug of choice for psychomotor epilepsy in the United States. This was because while carbamazepine and primidone are of roughly equal effectiveness, the former is less likely to cause sedation and cognitive impairment. Also, primidone has a greater tendency to cause undesirable psychiatric side effects compared with carbamazepine, which was noted to lessen pre-existing depressive symptoms. By 1978, it looked as if its superior side effect profile would increase its use in epilepsy in the United States.
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After the events of Second Coming, Cecilia is partnered with Psylocke and sent to Mexico to locate the second of the Five Lights; the first mutants to manifest powers since M-Day. After sedating Gabriel, she informs his parents of what is transpiring and offers him help from the X-Men. Psylocke comes to the room and explains that something has happened, Gabriel's manifesting speed powers caused him to move so fast he is invisible to the naked eye. Psylocke taps into Cecilia's powers to create a force field around his room so they would not lose him before Hope Summers could arrive to help.
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Benzodiazepines: This a drug class that works on the central nervous system to tackle a variety of medical conditions, such as seizure, anxiety, depression. As benzodiazepines suppress the activities of nerves in the brain, they also create a sedating effect which is utilized for multiple medical procedures and purposes. Among all benzodiazepine agents, midazolam (Versed) is the most frequently used medication for palliative sedation for its rapid onset and short duration of action. The main indication for the use of midazolam in palliative sediation is to control delirium and difficulty breathing to minimize the distress as well as prevent the exacerbation of these symptoms.
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TH-PVP is a substituted cathinone derivative which has been sold as a designer drug. It was first identified by a forensic laboratory in Hungary in 2015,EMCDDA–Europol 2015 Annual Report on the implementation of Council Decision 2005/387/JHA but has subsequently been found in numerous other countries around the world including Spain, Belgium, Poland, Turkey and Brazil. Pharmacological studies in vitro showed it to inhibit reuptake and promote the release of monoamine neurotransmitters with some selectivity for serotonin, but it failed to produce stimulant effects in animals, and has a pharmacological profile more comparable to that of sedating empathogens such as MDAI and 5-Methyl-MDA.
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The band's most controversial album, Frankenchrist, brought with it the song "MTV Get Off the Air," which accused MTV of promoting poor quality music and sedating the public. The album also contained a controversial poster by Swiss surrealist artist H. R. Giger entitled Penis Landscape. The Dead Kennedys toured widely during their career, starting in the late 1970s. They began playing at San Francisco's Mabuhay Gardens (their home base) and other Bay Area venues, later branching out to shows in southern Californian clubs (most notably the Whisky a Go Go), but eventually they moved to major clubs across the country, including CBGB in New York.
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In 1999, Just For Feet broadcast a commercial during Super Bowl XXXIII, produced by the agency Saatchi & Saatchi. In the spot, a group of Caucasian men in a humvee are seen tracking down a barefoot Kenyan runner, sedating him with drug-laced water, and forcing Nike shoes on his feet while he was unconscious. When he woke up, the runner rejected the shoes and attempted to shake them off whilst running away. The ad was widely-criticized by the media and advertising industry for its derogatory content; Stuart Elliot, advertising columnist for The New York Times, called it "appallingly insensitive", while Advertising Age columnist Bob Garfield described the commercial as being "neo-colonialist", "culturally imperialist", and "probably racist".
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In the episode "Mosley Lane", Bud Cort and Beth Grant guest-starred as Roger and Anita Roycewood, a married couple who abduct children and cremate their remains after sedating them. Ann Cusack guest-starred as Sarah Hillridge, an alcoholic mother and wife whose son has been missing for eight years, and Brooke Smith guest-starred as Barbara Lynch, a mother and wife whose daughter, Aimee, is abducted by the Roycewoods. Teen Wolf star Holland Roden appears in the episode "A Thousand Words" as Rebecca Daniels. In the episode "Solitary Man", Morgan Lily guest- starred as Jody Hatchett, a young girl whose father, Wade, abducts mothers for Jody and would later tell her about his escapades as fairytales.
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His cover is blown when he was shown on national television restraining Joy at a game show audition, so he, Joy, and their kids had to go under protection and assume other identities and live elsewhere. He agrees to join his father on one more mission, taking along Earl and sedating him multiple times, to free himself from having to need protection. In the episode "Our 'Cops' Is On" it is shown that he used to live with his supposed grandmother and grew and sold marijuana in his bedroom. In "Buried Treasure", he narrates that he graduated from college at age 14, was a virtuoso cellist, and could identify 254 varieties of cheese.
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EVT-201 is a benzodiazepine derivative drug and partial positive allosteric modulator of the benzodiazepine site of the GABAA receptor. It has 2–4-fold higher functional affinity for the α1 subunit relative to the α2, α3, and α5 subunits and significantly less intrinsic activity in comparison to currently- marketed benzodiazepines and the Z-drugs. Despite the lower efficacy, EVT-201 still shows effectiveness in the treatment of insomnia, and it is thought that the lower efficacy may result in fewer side effects, such as motor incoordination. The drug was originally developed by Roche, based on preclinical data, as a non-sedating anxiolytic, but was found to produce sedation in humans in phase I clinical trials.
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Coetsee was at the forefront of the campaign to de-horn rhinos under sedation, to make them safe from poachers who kill for the horn. He also pioneered the practice of managing elephant populations by sedating and moving entire family groups, from bulls and cows down to calves, in contrast to the practice of slaughtering the mature animals and relocating only youngsters. Moving family groups was seen as more successful in relocating the animals without ill effects, and has been repeated in several countries. In 1992 he had tracking microchips implanted under the skin of more than 40 elephants, which were being relocated from Zimbabwe's Gonarezhou National Park to South Africa because of drought.
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An H3 receptor antagonist is a classification of drugs used to block the action of histamine at the H3 receptor. Unlike the H1 and H2 receptors which have primarily peripheral actions, but cause sedation if they are blocked in the brain, H3 receptors are primarily found in the brain and are inhibitory autoreceptors located on histaminergic nerve terminals, which modulate the release of histamine. Histamine release in the brain triggers secondary release of excitatory neurotransmitters such as glutamate and acetylcholine via stimulation of H1 receptors in the cerebral cortex. Consequently, unlike the H1 antagonist antihistamines which are sedating, H3 antagonists have stimulant and nootropic effects, and are being researched as potential drugs for the treatment of neurodegenerative conditions such as Alzheimer's disease.
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Cyanodothiepin (developmental code name BTS-56424) is a tricyclic antidepressant (TCA) acting as a potent and highly selective (over norepinephrine and dopamine uptake) inhibitor of the reuptake of serotonin that was never marketed. It also has moderate affinity for the muscarinic acetylcholine receptors and weak/negligible affinity for the α1-adrenergic, 5-HT2A, D1, and D2 receptors; the H1 receptor has not been assayed, but cyanodothiepin is less sedating than the related drug cianopramine, suggesting that its antihistamine activity is not as pronounced as other TCAs. Cyanodothiepin is active in the forced swimming test (FST), implying that it may possess antidepressant properties in humans. However, it is only weakly active compared to cianopramine and imipramine in monoamine depletion-based tests of antidepressant potential.
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Renato Constantino, a 1980s Filipino critic compared American pop music influence on Filipinos as a sedating force that not only distorts reality, but cause the listeners or audiences to ignore true societal problems, hence a dangerous form of escapism for a society like the Philippines that was once a form colony. Filipinos and Filipino Americans have often debated about language in music, as language can be seen as an element of national identity. Various nationalists have also critiqued the use of English or "Taglish" which is a mix of Tagalog and English in works of art and especially music. Once again, in the 1980s a large focus on American or Americanized pop style songs was seen as a way to dissolve or weaken true Filipino cultural in a neo-colonial period.
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Machulina According to Nikolaev, the lives of the students should have been regulated in a nearly military communal fashion. After a common wake-up call all the students proceeded to common physical exercise areas (either a gym in winter or an open area in summer); at this moment the residential block was to be locked until late evening. After exercise, the students took a shower and dressed up in the public service locker rooms; after a breakfast in the canteen they followed their college schedule - either in off-site auditoriums or in the study block facilities. Nikolaev suggested injecting ozone into ventilation ducts at night and even considered sedating students to ensure they all fall asleep in due time (, "do not rule out the feasibility of sleepening additives").
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In 1945, Smith was facing execution by his captors but was saved by the atomic bombings of Hiroshima and Nagasaki which brought about the end of the war and Smith's liberation. He was said to have displayed "immense courage" to survive the horrific treatment he endured as a prisoner, and by the end of the war, he weighed only 6 stone. His resourcefulness in helping other prisoners was also noted: he made surgical tools to treat prisoners, sedating them with chloroform; he created a distillation unit to obtain clean water; he fixed a radio smuggled into the prison; and he found a way to diagnose malaria in his fellow prisoners earlier. After the war, Smith served in Germany on bomb disposal work for the Royal Army Ordnance Corps.
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According to law enforcement officials, DFSA perpetrators generally share four characteristics: they have access to sedating drugs and understand their effects, they have access to a setting (often a home or workplace) where the rape will not be interrupted while in progress, they are able to establish at least a small amount of trust with an intended victim, and they have a plan to avoid arrest and prosecution which may involve re- dressing the victim, telling the victim the rape was consensual or that no sexual contact took place, or exiting the premises before the victim regains consciousness. Researchers say that DFSA perpetrators are opportunistic and non-confrontational. They ordinarily do not threaten, force, batter or mutilate their victims, nor do they carry weapons, steal from their victims or destroy their property. They tend not to have a history of physical violence.
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Mirtazapine has demonstrated anxiolytic effects with a better side effect profile to all other classes of antidepressants, yet this is disputed by evidence that withdrawal is comparatively more severe than SSRI's, it is far more dangerous in overdose, it has a higher risk of causing life-threatening agrangulocytosis, it has more potential for adverse drug-drug interactions, and some find it noticeably sedating. It rarely causes or exacerbates anxiety, is sometimes particularly advantageous in certain individuals, with certain variants of depression, anxiety, or both, and its effectiveness tends to occur significantly faster than SSRIs. In many countries (such as USA and Australia), it is not specifically approved for anxiety disorders, being selected as an antidepressant when anxiety is co-occurring, or used off label. Use of mirtazapine for anxiety disorders in the absence of depressive symptoms is uncommon.
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She confronts her family at home during a family dinner, but her mother Samantha (Kristin Chenoweth), father Duncan (Matthew Modine), brother Jackson (Eddie Hassell), and sister Lucinda (Joey King) all continue to be wrapped up in themselves and ignore her plea to take her jump-roping seriously. Inspired by an Animal Planet segment her semi-autistic younger brother Mickey (Robbie Tucker) is watching on treating Tasmanian devils for a kind of cancer by sedating the creatures so treatment can be administered and in a desperate attempt to bring the family back together, Emily secretly drugs her parents' drinks with her mother's sedatives, then binds each of them to a chair. She manages to hold them until Sunday morning with help from her siblings, grandmother GG (Shirley Jones), and her school friend Kat (Chloe Bridges) who is her neighbor. During the weekend, she attempts to teach her parents how to parent.
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MDAI in powder form The family of drugs typified by MDMA produce their effects through multiple mechanisms of action in the body, and consequently produce three distinct cues which animals can be trained to respond to: a stimulant cue typified by drugs such as methamphetamine, a psychedelic cue typified by drugs such as LSD and DOM, and an "entactogen-like" cue which is produced by drugs such as MDAI and MBDB. These drugs cause drug-appropriate responses in animals trained to recognize the effects of MDMA, but do not produce responses in animals trained selectively to respond to stimulants or hallucinogens. Because these compounds selectively release serotonin in the brain but have little effect on dopamine or noradrenaline levels, they can produce empathogenic effects but without any stimulant action, instead being somewhat sedating. PMID Very high doses can be fatal in rats with a 50% fatality rate for those subcutaneously injected with 28 mg/kg of MDAI.
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Imidazenil is an experimental anxiolytic drug which is derived from the benzodiazepine family, and is most closely related to other imidazobenzodiazepines such as midazolam, flumazenil, and bretazenil. Imidazenil is a highly potent benzodiazepine receptor partial agonist with an unusual profile of effects, producing some of the effects associated with normal benzodiazepines such as anticonvulsant and anxiolytic effects, yet without any notable sedative or amnestic effects. In fact, imidazenil blocks the sedative effects of diazepam, yet without lowering the convulsion threshold, and so potentially could be a more flexible antidote than the antagonist flumazenil which is commonly used to treat benzodiazepine overdose at present. Imidazenil has not yet been developed commercially for use in humans, however it has been suggested as a safe and effective treatment for anxiety, a potent yet non-sedating anticonvulsant which might be particularly useful in the treatment of poisoning with organophosphate nerve agents, and as a novel treatment for schizophrenia.
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