"I am hoping this research project can improve the quality of life of multiple myeloma patients and improve drug treatments," said Linda Huguelet, a multiple myeloma patient in Chattanooga, Tennessee.
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The cause was multiple myeloma, his daughter, Julie Stein, said.
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He had multiple myeloma, a form of cancer, she said.
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Her son Reid Yalom said the cause was multiple myeloma.
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The cause was multiple myeloma, his wife, Julie Blatty, said.
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The cause was multiple myeloma, his daughter, Rachael Waller, said.
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Most of the affected combination studies were for multiple myeloma.
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Mel B's father died earlier this year after battling myeloma cancer.
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Multiple myeloma is the second most common form of blood cancer.
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She treats patients with myeloma, a type of bone-marrow cancer.
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His wife, Christine Covey O'Neal, said the cause was multiple myeloma.
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The cause was complications of multiple myeloma, his son, Richard, said.
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His wife, Esin Ili Goknar, said the cause was multiple myeloma.
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"I think I cured my first case of myeloma," he said.
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The cause was multiple myeloma, Priscilla Lenes, her former partner, said.
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The cause was complications of multiple myeloma, his son, Jerome, said.
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Martin Brown died Saturday after a 5-year battle with Myeloma.
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The drug targets a protein linked to multiple myeloma known as BCMA.
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Multiple myeloma and brain cancer were right behind, each costing $111 million.
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Multiple myeloma drug Ninlaro sales were 14 billion yen, up 40 percent.
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The cause was complications of multiple myeloma, his husband, Darryl Armbruster, said.
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Myeloma is a type of cancer that affects cells in bone marrow.
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The cause was multiple myeloma, his family said in a Facebook post.
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Don Baylor, who died of multiple myeloma at age 68 on Aug.
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The cause was complications of multiple myeloma, his wife, Geraldine Mattson, said.
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The cause was multiple myeloma, her granddaughter Zoë Sandler said on Tuesday.
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Velcade is used to treat multiple myeloma, a type of blood cancer.
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His wife, Margaret (Forian) Plumly, said the cause was complications of multiple myeloma.
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He had multiple myeloma, a form of cancer, his wife, Roberta Silman, said.
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To date, about 150 myeloma patients, 30 clinicians and 20 researchers have enrolled.
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Ninlaro treats a cancer called multiple myeloma, which is a type of blood cancer.
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Twenty percent of cases of multiple myeloma in the US are in black patients.
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Kyprolis is approved for multiple myeloma that has progressed after treatment with other medicines.
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The cause of death was multiple myeloma, a form of blood cancer, she said.
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Myeloma is a test ground for other cancers because it is so easily tracked.
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In the cancer ecosystem I became a traffic cop for others with multiple myeloma.
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Sheehan died last Monday at age 22008 after many years of battling multiple myeloma.
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The cause was complications of multiple myeloma, a form of cancer, his family said.
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But other researchers are exploring the same approach in different cancers, including multiple myeloma.
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Stottlemyre, 75, was found to have multiple myeloma, a bone marrow cancer, in 2000.
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AND UNFORTUNATELY, WE PROBABLY ALL KNOW SOMEBODY WHO HAS BEEN AFFECTED BY MULTIPLE MYELOMA.
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These cancer types were colon, breast, kidney, myeloma, liver, non-Hodgkin lymphoma and endometrial.
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The cause was complications of multiple myeloma, Fran Black, a longtime family friend, said.
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It also raised the price on Celgene&aposs flagship multiple myeloma drug, Revlimid, 6%.
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Black Americans are more than twice as likely to get multiple myeloma than white Americans.
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The study will enroll as many as 18 patients with myeloma, sarcoma, and melanoma cancers.
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Lenalidomide and pomalidomide are the widely used Celgene Corp multiple myeloma treatments Revlimid and Pomalyst.
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Coyne died Wednesday after battling multiple myeloma, the Doyle Funeral Home in New Jersey said.
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The company also presented positive results from a clinical study for a multiple myeloma treatment.
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For multiple myeloma, those rates were 26 percent in 1975 and 53 percent in 2010.
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Sales of Ninlaro, which treats multiple myeloma, a cancer of plasma cells, rose 35 percent.
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Take Revlimid, a drug to treat multiple myeloma and other blood cancers, as an example.
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Jones learned that he had multiple myeloma, a cancer of the bone marrow, in 2005.
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Jose got knocked down by what the family called stage III multiple myeloma and renal failure.
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Multiple myeloma drug Darzalex increased to $629 million from $432 in the same time last year.
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The thinking is that perhaps Black Americans are particularly susceptible to one subtype of multiple myeloma.
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The details: The study will reportedly involve 18 patients with multiple myeloma, sarcoma, and melanoma cancers.
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The medicine, (IVIG), helps myeloma patients by raising their body's antibodies, or cells that fight infection.
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Multiple myeloma is a cancer of plasma cells, the white blood cells responsible for producing antibodies.
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Primary Plasma Cell Leukemia is one of the rarest and most aggressive forms of Multiple Myeloma.
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Anticipating generic Velcade sales, Takeda has rolled out a follow-up multiple myeloma treatment called Ninlaro.
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Those exposed to the attacks also developed cancers that include lymphoma, leukemia and myeloma, it said.
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After Dr. Blau's myeloma was diagnosed in 2015, he decided to apply this approach to himself.
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Celgene: First-quarter profit almost hit $1 billion as demand for multiple myeloma drug Revlimid took off.
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Multiple myeloma is a type of aggressive and incurable blood cancer that develops in the bone marrow.
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Two had the blood cancer multiple myeloma and one had sarcoma, a cancer that attacks connective tissues.
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There is a nationwide shortage of the drug that helps myeloma patients, which has complicated Cecilio's job.
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Its analyses are dense: The last report on a blood cancer called multiple myeloma was 22019 pages.
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Three years ago, at age 73, I learned that I had an incurable cancer called multiple myeloma.
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Another friend and I got the news that we had multiple myeloma at about the same time.
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SANOFI SA: Sanofi said on Monday FDA approved Sarclisa® for patients with relapsed refractory multiple myeloma.
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Caitlyn M. Dlouhy, his editor at Simon & Schuster, said the cause was multiple myeloma with bone metastasis.
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Last year, he stepped down as interim chairman of CBS (CBS) due to complications from multiple myeloma.
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One of the patients, a woman with multiple myeloma, died in December, seven months after receiving the treatment.
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It's been nearly five months since Melanie "Mel B" Brown lost her father, Martin Brown, to myeloma cancer.
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The cause was complications of multiple myeloma and plasma cell leukemia, her son-in-law Andrew Regier said.
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The last patient in my story who I talked to, Thomas Goode, has had multiple myeloma since 2005.
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About 30,330 Americans are diagnosed with multiple myeloma and more than 12,600 die from the disease each year.
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Bluebird and Celgene expect to eventually test their CAR-T in patients with earlier-stage myeloma, he said.
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Bluebird hopes to have approvals for four new treatments, including one for multiple myeloma, by 2022, Leschly said.
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This is Czarina Cecilio, a registered nurse at the Multiple Myeloma Center at Weill Cornell Medicine in Manhattan.
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Infusion nurses are a type of RN with a license to inject medicine into myeloma patients with an
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They include cancers that spread from other organs or, like myeloma, could scar the skeleton in other ways.
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The Phase 1 clinical study demonstrated encouraging results in treating patients with late-stage relapsed-refractory multiple myeloma.
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Celgene is a bio-technology company based in Summit, New Jersey, that specializes in treatments for multiple myeloma.
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Ms. Daughn said myeloma was only the last of her sister's illnesses; she had had four previous cancers.
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Q. How does one typically die from cancer of the bone marrow, such as leukemia or multiple myeloma?
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Operational sales of J&J's multiple myeloma treatment Darzalex surged 23.5 percent in the quarter, hitting $26.5 million.
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D.B.'s family says the slugger was diagnosed with multiple myeloma -- a form of cancer -- 14 years ago.
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Multiple myeloma is an incurable blood cancer that occurs when malignant plasma cells grow uncontrollably in the bone marrow.
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The National Cancer Institute estimates there are 26,850 new cases of multiple myeloma each year in the United States.
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Management is likely to talk at length about its monoclonal antibody candidate in multiple myeloma, isatuximab, but Genmab GEN.
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The cause was complications of multiple myeloma, kidney failure and diabetes, his wife and business partner, Miriam Linna, said.
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She came to the firm in 2016 and previously worked as an advocacy associate at the International Myeloma Foundation.
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Several years ago, Mr. Parsons was found to have a rare form of blood cancer known as multiple myeloma.
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After Kerr's victory, she shared the heartbreak of losing her close friend Pam Kuehne to myeloma during tournament week.
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When asked about Revlimid on Wednesday, Hugin asserted that the multiple myeloma drug continues to be a valuable asset.
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So it's a new way of basically utilizing your body's own immune system to defeat a condition like myeloma.
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The first patient was dosed in the phase 2 multiple myeloma study of its lead oncology asset MP0250 and in the first phase 2 study, the efficacy and safety of MP0250 will be examined in combination with bortezomib (Velcade(R)) and dexamethasone in patients with multiple myeloma who have failed standard therapies.
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Unless you have multiple myeloma, a rare and vicious cancer of the blood, chances are you haven't heard of Revlimid.
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The company was set to lose patent protection by 2022 for Revlimid, its top-selling multiple myeloma drug, concerning investors.
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"We remain committed to exploring Kyprolis in combination with other agents to advance the treatment of multiple myeloma," Harper said.
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The DREAMM-1 study of patients with relapsed/refractory multiple myeloma confirmed the potential effectiveness of the medicine, GSK said.
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Mr. Case had Parkinson's disease and multiple myeloma and died in a hospice near his home, his wife, Susan, said.
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Fda grants priority review for daratumumab in relapsed multiple myeloma * Sbla was submitted by genmab's licensing partner, janssen biotech, inc.
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After 10 months of misdiagnosis, oncology blood work in May 2017 pinpointed the multiple myeloma that was poisoning her body.
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The results weren't much better even for treatments that could disproportionately benefit black people, such as multiple myeloma and prostate cancer.
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That way, when they're put back into the patient, the cells attack the tumor cells responsible for myeloma, melanoma, and sarcoma.
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The NBC News Senior Correspondent, 79, was diagnosed with incurable multiple myeloma, a rare type of cancer that causes bone pain.
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Multiple myeloma, which is the second most common blood cancer in the United States, is generally considered treatable but not curable.
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Merck (MRK) paused two late-stage studies involving the use of its Keytruda immunotherapy drug as a treatment for multiple myeloma.
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Merck – Merck paused two late-stage studies involving the use of its Keytruda immunotherapy drug as a treatment for multiple myeloma.
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I shadowed Czarina Cecilio, a 33-year-old registered nurse at Weill Cornell Medicine's Multiple Myeloma Center in New York City.
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"With myeloma, it's an incurable disease, [but] it's treatable, so that's why we see these patients all the time," Cecilio said.
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Mr. Brakel said its treatment for multiple myeloma, a bone marrow cancer, received early approval from the Food and Drug Administration.
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Darzalex is now established as a key treatment in multiple myeloma, where it is moving into earlier stages of the disease.
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Corner Office This interview with Kathy Giusti, founder of the Multiple Myeloma Research Foundation, was conducted and condensed by Adam Bryant.
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When you're working in multiple myeloma, nobody's ever heard of it, and it takes you half an hour to explain it.
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He was being treated for multiple myeloma, which affects plasma cells, for much of his time as the Yankees pitching coach.
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Multiple myeloma is estimated to cause nearly 13,000 deaths in the United States in 2019, according to the American Cancer Society.
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In the early 1990s, researchers at Boston Children's Hospital stumbled on an old sedative that appeared to slow the progress of myeloma.
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Bluebird Bio soared 14.1 percent to $1643 after the gene-therapy developer said patients undergoing its multiple myeloma treatment showed strong benefits.
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One of the most striking examples of this oversizing is a drug called Velcade that treats multiple myeloma, a bone marrow cancer.
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For example, with multiple myeloma, Black Americans have more than two times the likelihood of getting the cancer in the first place.
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Sales of the multiple myeloma drug Kyprolis jumped 45 percent to $172 million, shy of analysts' consensus forecast of about $185 million.
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Data from a late-stage trial involving 498 patients who had previously undergone one or more myeloma treatments was released on Sunday.
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The revision was driven by higher expected sales of Velcade, which is used to treat multiple myeloma, a type of blood cancer.
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Bluebird Bio soared 13.8 percent to $68.65 after the gene-therapy developer said patients undergoing its multiple myeloma treatment showed strong benefits.
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In the United States, nearly 95,000 people are living with, or in remission from, multiple myeloma, according to the National Cancer Institute.
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Many more CAR-Ts are in clinical trials, including a multiple myeloma treatment being developed by Bluebird Bio along with Celgene Corp .
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This posthumous collection of poems, written as the author was dying, of multiple myeloma, is a gentle but unflinching confrontation with mortality.
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On Monday, the French pharmaceutical giant won US approval for Sarclisa, a therapy for a type of blood cancer called multiple myeloma.
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The biotech firm has shown its platform can massively increase the number of natural killer cells in patients, which attack myeloma cells.
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The Ethicist A friend was recently diagnosed with multiple myeloma, a cancer of a type of white blood cell called plasma cells.
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Thalidomide, the morning sickness treatment that caused birth defects, is now approved for the treatment of multiple myeloma, a type of blood cancer.
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CBS interim Chairman Richard Parsons has stepped down from the board after about a month, citing difficulties in his fight against multiple myeloma.
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DeGagne was diagnosed with incurable multiple myeloma in 2013 and he slated one last romantic getaway with his wife this Christmas, to Hawaii.
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In the current study, 42 patients with multiple myeloma that worsened after at least two prior treatments were given AMG420 at varying doses.
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Brown announced the death in March, revealing in an Instagram post that Martin passed away after a five-year fight with multiple myeloma.
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In the United States, there are nearly 95,000 people living with, or in remission from, multiple myeloma, according to the National Cancer Institute.
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Among the examples in the study is Amgen's myeloma drug Kyprolis, for which one-third of a vial's contents on average is unneeded.
|
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Bluebird Bio shares soared 23 percent to $75 after the gene-therapy developer said patients undergoing its multiple myeloma treatment showed strong benefits.
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The U.S. Food and Drug Administration has already approved Kyprolis for patients with relapsed or refractory multiple myeloma who have previously undergone treatment.
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Because myeloma patients tend to need long-term treatment, Cecilio says a lot of them become friends with each other at the clinic.
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Multiple myeloma, a plasma cell cancer that affects the immune system, is another obesity-related disease that's becoming more prevalent in the US.
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" Mitchell himself has multiple myeloma, an incurable blood cancer, and said that the development of new cures is "very, very important to me.
|
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The decision by the Food and Drug Administration paves the way for a speedy regulatory review of the BCMA drug for multiple myeloma.
|
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A relatively unknown company, Nanjing Legend Biotech, also surprised ASCO participants with a small CAR-T trial in patients with advanced multiple myeloma.
|
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As cancerous leukemia or multiple myeloma cells grow unchecked, they fill precious bone marrow space and cause the normal cells there to die.
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The French drugmaker Sanofi has officially re-entered oncology, as the Food and Drug Administration approved the multiple myeloma treatment Sarclisa on Monday.
|
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We've learned Gallin has been at UCLA Medical Center in ICU after suffering a relapse of multiple myeloma, a type of blood cancer.
|
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He had been battling cancer for several years, revealing publicly in 2011 that he was in remission from the rare blood disease multiple myeloma.
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He had been battling cancer for several years, revealing publicly in 2011 that he was in remission from the rare blood disease multiple myeloma.
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The 36-year-old is part of a lab that works to cure aggressive melanoma, as well as a blood cancer called multiple myeloma.
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Last week, the U.S. Food and Drug Administration approved the biopharmaceutical company's cancer drug with existing drugs for a multipronged treatment of multiple myeloma.
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For more coverage of ASCO, see: here Bluebird and Celgene earlier this year began enrolling 80 patients for a larger study in multiple myeloma.
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Patients in bluebird's Phase I study had received on average seven prior treatments, including the newest multiple myeloma drugs, such as Johnson & Johnson's Darzalex.
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St. Louis Cardinals legend Lou Brock has been diagnosed with bone cancer and is currently receiving treatment for multiple myeloma, the team announced Thursday.
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As part of the study, 140,000 Icelanders over the age of 40 will have their blood samples tested for the precursor to multiple myeloma.
|
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Two patients in Dr. Stadtmauer's study have a blood cancer, multiple myeloma, and the third has a sarcoma, a rare cancer of connective tissue.
|
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His death was confirmed by his wife, Eugenia Radunsky, who did not specify the cause but said he had had multiple myeloma for years.
|
|
Revlimid sales, driven by longer duration of use in multiple myeloma, rose about 19 percent to $2.23 billion, above analysts' estimates of $2.21 billion.
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Two of the patients have multiple myeloma, a blood cancer, and the third has a sarcoma, cancer that forms in connective or soft tissue.
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Novartis is studying several other types of T-cells, with different genetic tweaks, to treat chronic lymphocytic leukemia, multiple myeloma as well as glioblastoma.
|
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The Yankees won the World Series in 1996, then captured consecutive championships from 1998 to 2000, the year Stottlemyre began treatments for multiple myeloma.
|
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Celgene is also a leader, he added, in treatments for multiple myeloma, a cancer that attacks the plasma cells that create antibodies to fight infections.
|
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Kyprolis has already been approved by the U.S. Food and Drug Administration for patients with relapsed or refractory multiple myeloma, who have previously been treated.
|
|
Takeda's myeloma drug, bortezomib, called Velcade, is only available in 3.5-milligram vials in the United States, but the average patient only needs 2.5 milligrams.
|
|
One company, Janssen, chose to ration its ovarian cancer and multiple myeloma drug Doxil on a first-come-first-served basis during a prolonged shortage.
|
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The infused medicine, which has a list price of $135,000 for the first full year of treatment, blocks the CD38 protein found on myeloma cells.
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Kyprolis has already been shown to be superior to Velcade, which is expected to go generic in 2017, in the later stages of multiple myeloma.
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This was about a year after the death of his wife, Shoshana, from multiple myeloma, a rare blood plasma cancer that affects the bone marrow.
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Rankin's brother, Jerry, died last year of multiple myeloma after prolonged exposure to contaminated water while serving in the Marines at North Carolina's Camp Lejeune.
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GenScript performs gene synthesis and biotech research for drug makers as well as developing its own treatments, including one for multiple myeloma, a blood cancer.
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The E.P.A. has classified it as likely to be carcinogenic to humans, as it is associated with bladder cancer, non-Hodgkin lymphoma and multiple myeloma.
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We're told Jon was diagnosed with multiple myeloma in 2008 -- he was also suffering from arthritis and had an infection related to a recent surgery.
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Wesley died Saturday at Cedar Sinai Hospital in Los Angeles, California, after a lengthy battle with multiple myeloma, said Gerry Pass, his manager and producer.
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The cause was myeloma, said Stephen P. Jenkins, a colleague at the London School of Economics, where Mr. Atkinson held the title of Centennial Professor.
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Amgen – Amgen's multiple myeloma treatment known as AMG420 received a "fast track" designation from the Food and Drug Administration, speeding up its path to possible approval.
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Amgen's (AMGN) multiple myeloma treatment known as AMG420 received a "fast track" designation from the Food and Drug Administration, speeding up its path to possible approval.
|
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Sales of Celgene's flagship multiple myeloma drug, Revlimid, rose 17 percent to $1.57 billion, accounting for about 58.5 percent of total product sales in the quarter.
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Brown announced her father Martin's death in March 2017, revealing in an Instagram post that he passed away after a five-year fight with multiple myeloma.
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The FDA did similar analysis to us, and found, like we did, that fewer than 5 percent of all participants in multiple myeloma trials are black.
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Donor registry must close gaps in donor options not only for leukemia patients, but also other blood diseases like sickle cell anemia, lymphoma and multiple myeloma.
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The agency also approved the drug as a single agent for patients with relapsed or refractory multiple myeloma who have received one or more previous treatments.
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"It is with great sadness after a 5yr battle to multiple myeloma cancer our loving father Martin Brown passed away age 63 peacefully yesterday," Brown wrote.
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Sales of Kyprolis, which extended patient survival in recent multiple myeloma trials, jumped 23 percent to $211 million, topping Wall Street estimates of about $203 million.
|
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Bluebird Bio shares soared 22.6 percent to $74 in premarket trading after the gene-therapy developer said patients undergoing its multiple myeloma treatment showed strong benefits.
|
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The study, ASPIRE, tested Kyprolis, chemically known as carfilzomib, in multiple myeloma patients whose cancer had relapsed following prior treatment or did not respond to treatment.
|
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GlaxoSmithKline PLC (GSK) says it has promising new data from a study of a possible treatment for people with multiple myeloma, a rare form of cancer.
|
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One of the main reasons why Cecilio chose to work as a nurse in a myeloma clinic was because of the bond she forms with patients.
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"It is with great sadness after a 5yr battle to multiple myeloma cancer our loving father Martin Brown passed away age 63 peacefully yesterday," Brown wrote.
|
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Lena Haddad, 53, of Germantown, Md., who has been living with multiple myeloma for four years, now gets a weekly dose of 1.8 milligrams of Velcade.
|
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The company, which is developing a therapy with Celgene Corp, gave an update on its clinical trial of multiple myeloma patients who had exhausted other options.
|
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Gallin was clinging to life at UCLA Medical Center where he was in ICU after suffering a relapse of multiple myeloma, a type of blood cancer.
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The company expects to submit for U.S. regulatory review another of its cancer candidates, isatuximab, to treat multiple myeloma later this year or in early 2019.
|
|
However, the clinical hold does not impact any of the approved indications for Venclexta, and is limited to investigational clinical trials in multiple myeloma, AbbVie said.
|
|
The science behind the Mayo Clinic report hinged on a genetically engineered measles virus, designed to kill a particular kind of cancer known as multiple myeloma.
|
|
Sales of its multiple myeloma drug Darzalex increased 53.5% year over year to $765 million, while sales of cancer drug Imbruvica increased 30.6% to $921 million.
|
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And she said she was very pleased to see progress in oncology and immuno-inflammation programs, including new drug candidates for multiple myeloma and rheumatoid arthritis.
|
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His wife, Jean Stottlemyre, said the cause was complications of multiple myeloma, a type of blood cancer for which he had been treated for many years.
|
|
For six of the 12 obesity-related cancers (multiple myeloma, colorectal, uterine, gallbladder, kidney and pancreatic) the risk for disease increased in adults 25 to 19853.
|
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Celgene rose 247 percent to $47 after the European Commission approved its flagship multiple myeloma drug for another indication and Stifel initiated coverage with a "buy" rating.
|
|
I've been able to start my own small business, which supports my family, and allows me to continue as caregiver to my husband (who has multiple myeloma).
|
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Sales of Darzalex, used to treat multiple myeloma, and Imbruvica, which J&J jointly sells with Abbvie Inc, also rose in double digits on a percentage basis.
|
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In the post's caption, Mel B paid tribute to her late father Martin Brown, who died in March after a five-year battle with multiple myeloma cancer.
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Amgen said AMG420, which targets a protein linked to multiple myeloma known as BCMA, has been given fast track status by the U.S. Food and Drug Administration.
|
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"He was already suffering with a really bad illness … my dad was going to die," the pop star said of her father, who was fighting multiple myeloma.
|
|
Kyprolis faces greater competitive pressure as newer entrants in the multiple myeloma market gain traction, including Johnson & Johnson's Darzalex, Bristol-Myers Squibb Co's Empliciti and Takeda's Ninlaro.
|
|
"I'm scared to death," said Mr. Drapeau, who has multiple myeloma, a type of blood cancer, and takes a drug that costs more than $10,000 a month.
|
|
Molecular Medicine signed an agreement with Genenta Science on a multi-year cooperation to develop and manufacture a gene therapy product for the treatment of multiple myeloma.
|
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"Ten years ago, the median survival for myeloma was about two years," Alles said on "Squawk Box " at the American Society of Hematology annual meeting in Atlanta.
|
|
This week, the therapies took center stage at the American Society of Clinical Oncology (ASCO) annual meeting, with new results on their use for multiple myeloma patients.
|
|
But just as she was blinking into the new light, Ms. Ingalls learned she had myeloma, a cancer of the blood, and was told it was terminal.
|
|
A. People diagnosed with leukemia and multiple myeloma, both cancers originating in the bone marrow, are living much longer than they did just a few decades ago.
|
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Similarly, for multiple myeloma, a British study of over 3,100 patients treated from 1980 to 2002 found that 10 percent died within 60 days of starting therapy.
|
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The company is running trials testing it in patients with earlier cases of multiple myeloma, as well as in combination with cancer drugs made by rival companies.
|
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The FDA said based on available data the risks of combining Keytruda with either of the Celgene medicines outweigh any potential benefit for patients with multiple myeloma.
|
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Survivors of multiple myeloma, a cancer of the plasma cells in bone marrow, were 70 percent more likely to develop cardiovascular disease than people who didn't get cancer.
|
|
For all people, the largest increases in incidence were for liver cancer, myeloma, melanoma, thyroid cancer, and leukemia, and there were smaller rises in kidney and breast cancer.
|
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The BCMA protein that is characteristic of multiple myeloma is also being used as a target in cell therapies developed by Johnson & Johnson, bluebird bio Inc, Celgene Corp.
|
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Then, using CRISPR, researchers would genetically modify the T cells so that when they're put back into the patient, they go after myeloma, melanoma, and sarcoma tumor cells.
|
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Shares of Ligand Pharmaceuticals shed nearly 12 percent Tuesday after Amgen said its multiple myeloma drug, Kyprolis, did not outperform Takeda Pharmaceutical's Velcade in a late-stage study.
|
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Karyopharm Therapeutics — Karyopharm announced in a conference call Wednesday afternoon that Xpovio, a drug aimed at treading refractory multiple myeloma, was approved by the Food and Drug Administration.
|
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"This is the guy that treats the person and not just the disease," says patient Roger Gagos, 73, who has multiple myeloma, an uncommon form of blood cancer.
|
|
They include an antibody drug for multiple myeloma, which could be launched in 2020, as well as new kinds of cell therapies designed to modify patients' immune cells.
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And while there are multiple drugs that have made a "big difference" for multiple myeloma patients, unfortunately the cancer comes back in a lot of patients, Leschly said.
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Obesity-associated cancers considered by the researchers included myeloma, female breast cancer and cancers of the colon and rectum, gallbladder, esophagus, stomach, liver, pancreas, uterus, kidney and thyroid.
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Included are cancers of the esophagus, liver, gallbladder, colon and rectum, upper stomach, pancreas, uterus, ovary, kidney and thyroid; breast cancer in postmenopausal women; meningioma and multiple myeloma.
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Celgene will lose patent protection for Revlimid, its top-selling multiple myeloma drug that brought in about 60 percent of fiscal third quarter revenue of nearly $3.3 billion.
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Diagnosed himself with myeloma in April 2015, Tony infuses All4Cure with an incredible sense of urgency to improve the prospects for cancer patients now and in the future.
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Amgen also said that AMG420, which targets a protein linked to multiple myeloma known as BCMA, has been given fast track status by the U.S. Food and Drug Administration.
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Walmsley said the company had extensive plans for its experimental drug to treat multiple myeloma, which targets a protein called BCMA, adding that it could be launched by 2020.
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Gryzbowski and his colleagues tested their retrosynthetic program on three major commercial medicines: linezolid, a last-resort antibiotic; sitagliptin, an antidiabetic drug; and panobinostat, a treatment for multiple myeloma.
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Reuters has not verified the newspaper reports, and cannot vouch for their accuracy: Australian Regulatory Agency (TGA) has approved Aplidin® to treat multiple Myeloma in combination with Dexamethasone.
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"It helps a lot mentally ... to feel beautiful and to feel that the medicine didn't change us," said Khalil, 46, who suffers from multiple myeloma, a blood plasma cancer.
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Celgene loses patent protection by 2022 for Revlimid, its top-selling multiple myeloma drug that brought in about 60 percent of fiscal third-quarter revenue of nearly $3.3 billion.
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I learned that not only did Cecilio have to know the ins and outs of myeloma treatment for her patients, she was constantly managing interpersonal relationships around the clinic.
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Before meeting with patients, Cecilio goes over the patient schedule with Dr. Ruben Niesvizky, an oncologist and the director of the myeloma center, and Stephen Veefkind, an infusion nurse.
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SANOFI Sanofi said the U.S. Food and Drug Administration has accepted for review the Biologics License Application for isatuximab for the treatment of patients with relapsed/refractory multiple myeloma.
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When his wife Becky was diagnosed with multiple myeloma in 513, the couple traveled 100 miles from their Staunton, Virginia, home so she could have a stem cell transplant.
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My husband had myeloma, like Mr. Brokaw, and frequently interacted with doctors, nurses and certified nursing assistants in hospitals and doctors' offices as well as chemotherapy and radiation centers.
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Celgene loses patent protection by 2022 for Revlimid, its top-selling multiple myeloma drug that brought in about 60 percent of fiscal third quarter revenue of nearly $3.3 billion.
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Previous studies have shown that long-term users of dark dyes have a four-fold increased risk of fatal non-Hodgkin's lymphoma and fatal multiple myeloma, the authors write.
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Xpovio's approval on Wednesday was based on results from a mid-stage study of 122 multiple myeloma patients who had previously received three or more treatment regimens, Karyopharm said.
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Bluebird's drug, being developed in partnership with Celgene Inc, was able to induce remission in several patients with advanced multiple myeloma with no worrisome side effects in a small study.
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The other two—another woman with multiple myeloma and a man with sarcoma (the one who's tumor shrank)—have since had their cancer worsen and are now receiving other treatments.
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The trials are testing AstraZeneca Plc's key immunotherapy, Imfinzi, in combination with chemical agents, with or without chemotherapy, in blood cancers such as multiple myeloma, chronic lymphocytic leukaemia and lymphoma.
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Earlier at the ASH meeting, bluebird and Celgene presented early trial data showing that experimental cell therapy bb21217 induced responses in 10 out of 12 heavily pre-treated myeloma patients.
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The strong performance of Darzalex, which is currently approved to treat multiple myeloma, prompted six upward revisions to the company's revenue and operating profit guidance for its 2900 financial year.
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It is being used in studies to treat six types of cancer, including a rare from of soft tissue cancer, as well as in a combination study in multiple myeloma.
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"BMS remains steadfast in our commitment to improve outcomes for patients with multiple myeloma, and will work closely with the FDA to address concerns," the company said in a statement.
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In the head-to-head trial of 929 patients whose multiple myeloma had relapsed following prior treatment, those who received Kyprolis plus low-dose dexamethasone on average lived 47.6 months.
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"It is with great sadness after a 5yr battle to multiple myeloma cancer our loving father Martin Brown passed away age 63," the former Spice Girl wrote in the caption.
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They include an antibody drug for multiple myeloma, which could be launched in 2020, as well as new kinds of immunotherapy and cell therapies designed to modify patients' immune cells.
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For more click Genmab A/S said it is beginning phase Ib studies of daratumumab in combination with Roche's immune checkpoint inhibitor atezolizumab in a solid tumor and multiple myeloma.
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She also sent off a test to look for a type of blood cancer called multiple myeloma, which attacks the blood and bones and is seen in patients over 50.
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Achimugu, a former managing director of Nigeria's Pipelines and Product Marketing Company, had underlying medical conditions including multiple myeloma and diabetes and he was also undergoing chemotherapy, the NCDC said.
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About a month ago, GSK said it would seek U.S. Food and Drug Administration approval for belantamab mafodotin, a treatment for multiple myeloma, which is a type of blood cancer.
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A diagnosis of multiple myeloma, cancer of the plasma cells, motivated Dr. C. Anthony Blau of the University of Washington to come up with an innovative approach to his disease.
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Dr. Blau's enthusiasm sparks my realization that the sort of networking available to myeloma patients through All4Cure would transform the lives of the women in my gynecological cancer support group.
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" But Bonnie Falbo of Charlottesville, Va., a caregiver for her 70-year-old husband, who has multiple myeloma, said: "This treatment is one that could save his life one day.
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The lead investigator on her case, Carl Burrell, had retired from the FBI by the time Israel died in late 2014, of complications from myeloma, at the age of 75.
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In addition, revenue from Celgene's flagship multiple myeloma drug, Revlimid, which brought in nearly $10 billion last year, is set to start dropping in 2022 when it loses U.S. exclusivity.
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Earlier at the ASH meeting, bluebird and partner Celgene Corp presented early trial data showing that experimental cell therapy bb203 induced responses in 10 out of 12 heavily pretreated myeloma patients.
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In the current study, 42 patients with multiple myeloma that worsened after at least two prior treatments were given AMG420 at varying doses - the highest dose was discontinued due to toxicity.
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ALEX GORSKY: And we-- we're working hard on multiple myeloma, lymphoma and other diseases-- JIM CRAMER: This is one of the reasons-- ALEX GORSKY: --to-- JIM CRAMER: --why I'm recommending you.
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Two doses of belantamab mafodotin helped subdue the disease in adults who had received three prior treatments for multiple myeloma, a cancer of the white blood cells, GSK said on Friday.
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In addition, revenue from Celgene's flagship multiple myeloma drug, Revlimid, which brought in nearly $10 billion last year, is set to start dropping in 2022 when it loses its U.S. exclusivity.
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Sergio Giralt, MD is the Melvin Berlin Family Chair in Myeloma Research; Professor of Medicine at Weill Cornell Medical College and Chief Attending, Adult BMT Service, Memorial Sloan Kettering Cancer Center.
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Merck — The Food and Drug Administration (FDA) placed a clinical hold on three studies that tested the use of immunotherapy drug Keytruda in combination with other drugs to treat multiple myeloma.
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There was some good news elsewhere, with progress reported on a promising drug for multiple myeloma and an unexpectedly strong endorsement of the company's new shingles vaccine from U.S. vaccination officials.
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Sales of J&J's rheumatoid arthritis drug Remicade increased 5.4% in the fourth quarter to $3.5 billion, while sales of its multiple myeloma drug Darzalex increased by 9.1% to $2.7 billion.
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The European Medicines Agency (EMA) conditionally endorsed Darzalex, or daratumumab, and said they needed results from two late-stage studies testing Darzalex in combination with standard treatments for multiple myeloma. (bit.
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Hanna Olivas knows that she is dying from multiple myeloma, a rare blood cancer, and she knows exactly how she wants her loved ones to think about her when she's gone.
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Hanna, now 45, was diagnosed with multiple myeloma in 2017 and after undergoing multiple rounds of chemotherapy and other treatments, doctors told her there is little less that they can do.
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"We've had a lot of positive data for patients, whether that be on the Tesaro acquisition ... or our new drug in multiple myeloma," she said in a sit-down with Cramer.
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TOKYO (Reuters) - Takeda Pharmaceutical Co Ltd on Friday posted a 34.43 percent rise in third-quarter operating profit, supported by strong sales of its drugs for bowel disease and multiple myeloma.
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The medicine, which is given by infusion, is now being tested in multiple myeloma in combination with three immunotherapies — Roche's Tecentriq, Bristol-Myers Squibb's Opdivo and durvalumab, from AstraZeneca and Celgene.
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The FDA placed a hold on three Merck multiple myeloma combination trials in July after safety monitors reported more deaths among patients who received Keytruda than those in the control group.
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Xpovio was approved in combination with dexamethasone for multiple myeloma patients who have received at least four prior therapies and who failed to respond to certain other treatments, the FDA said.
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With (possibly related) zeal, Dr. Blau soon started All4Cure, a knowledge-sharing platform for clinicians, researchers and myeloma patients who register (without cost) to allow their medical records to be accessed.
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Sales of the multiple myeloma drug came in at $22.54 billion - in line with consensus estimates - accounting for about 22016 percent of the company's total revenue in the quarter ended Dec. 21.
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The drug, Darzalex, received U.S. approval in November for use by itself among patients who had received at least three prior treatments for myeloma, a cancer of infection-fighting white blood cells.
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Pam Holt of Granger, Indiana, had to refinance her home last year to afford $640 a month in copays for a drug to treat her multiple myeloma, a type of blood cancer.
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Shares of Merck dropped 2 percent after the FDA put a clinical hold on three studies by the pharmaceutical company involving a potential treatment for multiple myeloma, a type of blood cancer.
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The patient didn't have multiple myeloma either, though that test, which measures levels of one part of the immune system known as antibodies, was abnormal; one antibody, known as IgM, was high.
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According to the company, Aplidin, which is approved for the treatment of multiple myeloma in Australia, would block the EF1A protein and make the reproduction of the virus inside the cell unfeasible.
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One of my hospital's specialists in multiple myeloma, a bone marrow cancer with a previously dismal prognosis, recently told me that he had treated a patient with a new kind of immunotherapy.
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It involved three tests on the participants' blood samples and showed sensitivity in detecting 10 types of cancer: colorectal, esophageal, head and neck, hepatobiliary, lung, lymphoma, multiple myeloma, ovarian, pancreatic and breast.
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It noted that two of the three drugs already have generic versions licensed to enter the market in coming years, including multiple myeloma treatment Revlimid, by far the company's biggest selling product.
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The bar was set relatively low because "it's not very often that we come across a transformative treatment," said Dr. Sham Mailankody, an assistant attending physician and myeloma specialist at Memorial Sloan Kettering.
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The FDA themselves published an article, in 2017, where they said meaningful differences may exist in how multiple myeloma affects Black patients and what symptoms they experience and how they respond to medication.
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U.S. health regulators on Wednesday placed a partial hold on three trials testing Opdivo in combination with other medicines for multiple myeloma due to risks seen in similar studies on a rival drug.
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Patients with relapsed multiple myeloma taking part in the trials who were experiencing clinical benefit will be allowed to continue treatment, but no new patients will be enrolled for now, Bristol Myers said.
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Earlier this month, Keytruda trials in the blood cancer multiple myeloma were stopped due to more deaths among those who received Keytruda along with standard combination therapy than those on standard treatment alone.
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Danish biotech firm Genmab fell 24 percent after it ended combination trials of its multiple myeloma drug Darzalex with Tecentriq, citing "no observed benefit" and an increase in deaths after the combination treatment.
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Its cancer treatment Abraxane generated sales of $233 million, trailing the consensus estimate by $17 million, while its other multiple myeloma drug Pomalyst brought in $341.1 million, ahead of expectations of $327 million.
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Six of the 12 obesity-related cancers — colorectal, uterine corpus (endometrial), gallbladder, kidney, multiple myeloma, and pancreatic — showed increased incidences in young adults and in successively younger birth groups in a stepwise manner.
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One study, with results expected early next year, could win it approval to be administered in multiple myeloma patients at an early point in the treatment process, expanding the patient population it serves.
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One study, with results expected early next year, could win it approval to be administered in multiple myeloma patients at an early point in the treatment process, expanding the patient population it serves.
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The team also noted that there were ties linking glyphosate to multiple myeloma, but the evidence for that disease was not as strong as the evidence tying glyphosate to NHL, the group determined.
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The news follows Bristol-Myers Squibb Co's announcement on Wednesday that the FDA had placed similar partial clinical holds on three trials of the company's Opdivo immunotherapy in combination with multiple myeloma treatments.
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That's how many years I've been living and running since I was diagnosed with multiple myeloma, a rare cancer in the bone marrow that used to have a life expectancy of just three years.
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Baylor, who played 19 seasons in his major league career and was the 1979 American League MVP, died at a hospital in his native Austin, Texas, after a 14-year struggle with multiple myeloma.
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Those with multiple myeloma may be treated initially with combinations of three or four drugs that can reduce the risk of the disease worsening or of dying by 50 percent compared to earlier treatments.
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The Las Vegas mom of four was diagnosed with multiple myeloma, a rare blood cancer, in 2017, but has spent the years since fighting for her right to end her life on her terms.
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"We've had a lot of positive data for patients, whether that be on the Tesaro acquisition ... or our new drug in multiple myeloma," she said in a sit-down with show host Jim Cramer.
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AstraZeneca's drug is also in development for the treatment of multiple B-cell malignancies and other blood cancers including chronic lymphocytic leukemia, Waldenström macroglobulinaemia, follicular lymphoma, diffuse large B-cell lymphoma and multiple myeloma.
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The Food and Drug Administration's decisions stem from safety concerns uncovered in similar blood cancer trials of Merck & Co Inc's rival Keytruda medicine in combination with widely used multiple myeloma drugs that Celgene sells.
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After poring through charts to diagnose a patient with multiple myeloma, a blood cancer masquerading as schizophrenia, she writes that it is proof that being rushed in medicine is not only wasteful but dangerous.
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Blatty died Thursday at a hospital near his home in Bethesda, Md., his widow, Julie Alicia Blatty, told the Associated Press, adding that the cause of death was multiple myeloma, a form of blood cancer.
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The department said Onyx Pharmaceuticals, which Amgen acquired in 2013, also used Chronic Disease Fund as a means to improperly pay the out-of-pocket costs of Medicare patients using its multiple myeloma drug Kyprolis.
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Shares of Bluebird Bio rose as much as 30 percent to a record high of $222.03 after its experimental gene-modifying immunotherapy drug co-developed with Celgene received positive responses in early stage myeloma study.
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"Endeavor is the only (relapsed multiple myeloma) study to demonstrate a survival benefit in a head-to-head comparison with a current standard of care regimen," Amgen research chief Sean Harper said in a statement.
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CHICAGO (Reuters) - Patients with advanced multiple myeloma treated with bluebird bio's experimental immunotherapy lived for a median of nearly a year before their cancer worsened, according to data from a small study presented on Friday.
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Analysts are specifically watching Bluebird and Juno in the CAR-T space; Bluebird for updates in its program targeting multiple myeloma, and Juno for its program in non-Hodgkin lymphoma, according to research from JPMorgan.
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Shares of Bluebird Bio Inc closed 14 percent higher on Thursday after a small study showed that its CAR-T, bb2121, induced remission in several patients with advanced multiple myeloma with no worrisome side effects.
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The Novartis drug has the potential to be one of the most expensive drugs ever sold, said David Mitchell, the patients group's president, who has been treated for multiple myeloma, a blood cancer, since 2010.
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Sanofi, whose shares have underperformed major rivals, reiterated its strategy to rebuild its position in cancer and said it expected a first regulatory submission of its monoclonal antibody for relapsed refractory multiple myeloma in 2018.
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AbbVie said it was also studying the drug in a wider population of patients with CLL, including those without a genetic mutation who have failed previous therapies, and in other blood cancers, including multiple myeloma.
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Dressed in his workout gear, he makes rounds, visiting patients whose ailments run the gamut: pneumonia, respiratory failure, colon cancer, lupus, black lung disease, dementia, heart attack, kidney infection and multiple myeloma, a bone cancer.
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For example, compared with people born in 1950, those born in 1985 had a risk of multiple myeloma 59 percent higher, and a risk of pancreatic cancer more than twice as high at comparable ages.
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This year's reassessment added to this list gastric cancer, liver, gallbladder, pancreas, ovary and thyroid cancers as well as the blood cancer multiple myeloma and meningioma -- cancer that affects the tissue surrounding the brain and spine.
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Investors have been concerned about patent challenges to its long-time cash cow Revlimid for multiple myeloma and the surprise failure last week of an experimental Crohn's disease drug touted as a future multibillion-dollar product.
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The potential to use Darzalex, a key treatment in multiple myeloma, in solid tumors was eagerly awaited and some analysts had seen the outcome of the study as this year's biggest price trigger for the stock.
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Revlimid, a multiple myeloma treatment with annual sales of about $6 billion, was being tested versus a placebo in patients whose diffuse large B-cell lymphoma had responded to initial treatment with Roche's Rituxan and chemotherapy.
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"She has made him happy and better rounded," said Dr. Angelos M. Stergiou, the chief executive of Sellas Life Sciences Group in New York, who is working with Dr. Koehne on a vaccine for multiple myeloma.
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NOW WITH THIS DEAL IN PARTICULAR, FIRST OF ALL, IT GETS US INTO THE CELL-BASED THERAPY THE DCMA CAR-T APPROACH WHICH WE'RE REALLY EXCITED ABOUT, AND WE COULD START SEEING CURES IN MULTIPLE MYELOMA.
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Brokaw, who spent more than 20 years as anchor and managing editor of NBC Nightly News, was diagnosed with multiple myeloma, an incurable cancer that forms in the blood plasma, three years ago at age 73.
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Amgen, updating the first trial of its bispecific antibody for multiple myeloma, said on Monday seven out of 220 patients given the second-highest dose of AMG217 responded to the drug, including four with no detectable cancer.
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J&J, which licensed BCMA-directed CAR-T LCAR-B38M from a unit of China-based GenScript Biotech, on Monday presented updated results from a Chinese study of the cell therapy in 57 previously treated myeloma patients.
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Multiple myeloma, a type of aggressive and incurable blood cancer that develops in the bone marrow, kills about 12,600 people annually and will be diagnosed in about 30,000 Americans this year, according to the American Cancer Society.
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Once all Icelanders that have the precursor for multiple myeloma are identified, they will be tracked to see how the disease is progressing, so doctors can offer treatment at the earliest possible time to achieve a cure.
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O) closed up 17.9 percent at $201.8, after hitting a record high of $222.03, following news of positive responses in an early stage myeloma study of its experimental gene-modifying immunotherapy drug co-developed with Celgene (CELG.
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The data could lead to expanded approvals of the Darzalex combination as an initial, or first-line, therapy for multiple myeloma, providing a larger sales opportunity for the medicine, one of J&J's most important growth drivers.
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Its treatment is for a type of leukemia, and it is working on similar types of treatments in hundreds of patients for another form of the disease, as well as multiple myeloma and an aggressive brain tumor.
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Within the past few years, the US Food and Drug Administration has approved Farydak for treating multiple myeloma, Avycaz for abdominal infections, Vraylar for schizophrenia, Idelvion for hemophilia, Luzu for athlete's foot and Byvalson for high blood pressure.
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Still, nothing had ever been as effective against multiple myeloma, so a biotechnology company called Celgene took a risk and spent millions of dollars developing an analogue of the compound, transforming thalidomide into a more potent cancer drug.
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Ex-bass player, Leonard "Hub" Hubbard, started in the Philly band in 1992 -- before they were even called The Roots ... and played with them until 2007, when he was diagnosed with multiple myeloma ... a form of blood cancer.
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Celgene raised its 22.75 profit forecast and exceeded expectations for second-quarter earnings on Thursday on the strength of its flagship multiple myeloma drug Revlimid and growth in newer medicines, sparking a 2598.2 percent jump in its shares.
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J&J, which licensed BCMA-directed CAR-T LCAR-B38M from a unit of China-based GenScript Biotech Corp, on Monday presented updated results from a Chinese study of the cell therapy in 57 previously treated myeloma patients.
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ZURICH (Reuters) - Molecular Partners said on Friday that five of eight patients with advanced multiple myeloma in a Phase II study showed an objective response to a combination therapy that includes an investigational drug from the Swiss company.
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On a conference call with analysts, the company and experts said the "treatment landscape" for multiple myeloma was evolving dramatically and that melphalan/prednisone-based regimens were now rarely used due to their low efficacy and high toxicity.
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"The first thing that investors and the medical community ... [are] realizing is that this class of medicine of CAR-T therapy — whether its lymphoma, leukemia or myeloma — will replace existing chemotherapy," Alles said in a "Squawk Box " interview.
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Stottlemyre's fellow coach Don Zimmer recalled that after Stottlemyre revealed he had multiple myeloma in April 2000, he remained strong and steady while coaching the Yankees' pitchers for most of the regular season, even as he received chemotherapy.
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The Downsizing star, 47, gave a health update on his 74-year-old father Kent, who has been battling cancer since 2011 when it was publicly revealed that he was in remission from the rare blood disease, multiple myeloma.
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The other two treatments are bluebird's CAR-T therapy for multiple myeloma, being developed with partner Celgene Corp, and a treatment for a rare and deadly genetic brain disorder, cerebral adrenoleukodystrophy, both of which have demonstrated impressive early results.
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There is evidence that excess body fat causes a greater risk of 13 cancers, according to the report: postmenopausal breast, colon/rectum, corpus uteri (endometrium), esophagus (adenocarcinoma), gallbladder, kidney, liver, meningioma, multiple myeloma, ovary, pancreas, stomach (cardia) and thyroid.
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Last year, Elaine Kodish, a 76-year-old retiree from Los Angeles, briefly stopped taking Revlimid after her Medicare drug plan required she pay more than $450 a month for the drug that keeps her multiple myeloma in check.
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Chief Executive Alex Gorsky said that when drugs add months or years to patient lives and make significant differences on health outcomes, as with multiple myeloma treatment Darzalex and leukemia drug Imbruvica, the company has experienced less pricing pressure.
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"As some of you know, when I agreed to join the board and serve as the interim chair, I was already dealing with a serious health challenge -- multiple myeloma -- but I felt that the situation was manageable," Parsons said.
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For more click The Swiss drugmaker said on Friday that five of eight patients with advanced multiple myeloma in a Phase II study showed an objective response to a combination therapy that includes an investigational drug from the Swiss company.
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SAN DIEGO (Reuters) - Amgen Inc, updating the first trial of its bispecific antibody for multiple myeloma, said on Monday seven out of 220 patients given the second-highest dose of AMG217 responded to the drug, including four with no detectable cancer.
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Amgen was the biggest drag on the S&P and the Nasdaq, dropping 1.9 percent after the drugmaker said its multiple myeloma drug was not found to be superior to Takeda's Velcade in a late-stage study in previously untreated patients.
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The additional payments from the Department of Veterans Affairs would start in March and go to veterans who developed adult leukemia, aplastic anemia, bladder cancer, kidney cancer, liver cancer, multiple myeloma, non-Hodgkin's lymphoma and Parkinson's disease, the notice said.
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Studies have found that New York firefighters who responded to the 9/11 attacks were 10% more likely to develop cancer than the general population and that they are more likely to develop myeloma precursor disease, which can develop into cancer.
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The company hired a team of 60 sales representatives, many of whom had experience in oncology, according to financial filings, and just months after Thalomid arrived on the market, Celgene announced that it would pursue F.D.A. approval for multiple myeloma.
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GSK, which is battling to return to profit growth, has taken this approach for instance with an experimental drug that for now goes by the code name of GSK'916 against multiple myeloma, a common and incurable type of blood cancer.
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SAN DIEGO Dec 3 (Reuters) - Amgen Inc, updating the first trial of its bispecific antibody for multiple myeloma, on Monday said seven out of ten patients given the second-highest dose of AMG420 responded to the drug, including four with no detectable cancer.
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But the failure of cancer drug Rova-T, once seen as a strong contender for a new blockbuster, and setbacks to the testing of multiple myeloma drug Venclexta have pressured AbbVie shares, which are down nearly 14 percent over the past 12 months.
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Hematopoietic cell transplantation is a standard treatment for a range of conditions, including malignant diseases such as multiple myeloma, non-Hodgkin's lymphoma, Hodgkin's disease, and acute myeloid leukemia, as well as non-malignant diseases and autoimmune disorders such as aplastic anemia and thalassemia.
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But the time to make amends had come too late: The 22009-year-old rapper was in a medically induced coma at Good Samaritan Hospital in Rockland County, N.Y., living out his last days with multiple myeloma, a rare form of cancer.
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Two doses of the drug, also called GSK2857916, boosted response rates in adults who received prior treatment for multiple myeloma, a cancer that forms in white blood cells, GSK said, adding that it intends to submit data from the trial for regulatory filings.
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Some Bristol-Myers investors are against the planned $74 billion takeover of Celgene, as they see potential risk associated with Celgene's pipeline, and expect a drop in sales of its flagship multiple myeloma drug, Revlimid, when it loses U.S. exclusivity in 2022.
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Revlimid is in "beast mode" and had a "monster" quarter, Cowen & Co analyst Eric Schmidt wrote in a client note, adding that European sales may finally be seeing the inflection that investors had hoped for following reimbursement approval in previously untreated myeloma patients.
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To participate in the study, which concludes in July 2020, patients must be 18 years or older and have a histological- or cytological-proven diagnosis of a malignancy in the lung, breast, head and neck, genitourinary organs or ovaries or multiple myeloma.
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NEW YORK (Reuters) - Celgene Corp raised its 22.75 profit forecast and exceeded expectations for second-quarter earnings on Thursday on the strength of its flagship multiple myeloma drug Revlimid and growth in newer medicines, sparking a 2598.2 percent jump in its shares.
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Celgene and Bluebird Bio announced on Sunday updated, positive results from their early stage study on a therapy for people with multiple myeloma — a blood cancer that develops in plasma cells, affecting hundreds of thousands of people in the U.S. each year.
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Patients who are currently enrolled in studies and receiving the therapy may continue with the treatment, but no new patients should be enrolled in trials testing Venclexta for multiple myeloma until a further analysis of the data is completed, the drugmaker said.
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"Outcomes with traditional standard of care for this highly refractory patient population have been extremely poor," said Dr. Sattva Neelapu, co-lead investigator on the trial and professor of lymphoma and myeloma at the University of Texas MD Anderson Cancer Center in Houston.
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This legislation would, most crucially, benefit patients like those with multiple myeloma being kept alive by the drug Revlimid, but who cannot afford the drug after the price rose by nearly 20% in 2017 alone, and 88% over the last 7 years.
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I mean, the fact that we are sitting around conference rooms frequently now talking about, you know, the opportunity to transform something like multiple myeloma, which could have been a death sentence five or ten years ago, into potentially coming up with a cure.
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The company plans to make its regulatory submissions to the U.S. Food and Drug Administration next year for the treatment, which was first approved by the FDA in November 2015 as a monotherapy for multiple myeloma patients who had received at least three prior therapies.
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The FDA in July placed a hold on three Merck & Co multiple myeloma trials testing its Keytruda along with other standard medicines for the blood cancer following reports of more deaths in patients who received Keytruda than in the control arms of the studies.
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Verily has also beefed up its scientific advisory board, adding Linda Avey, the co-founder of 23andMe, as well as former Medicare chief Andy Slavitt, former national coordinator for Health Information Technology Karen DeSalvo, and Kathy Giusti, founder of the Multiple Myeloma Research Foundation.
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Check out which companies are making headlines after the bell: Shares of fell more than 2 percent during after-hours trading following a pause in enrollment for two studies of Keytruda, its drug to treat multiple myeloma, due to an imbalance in patient deaths.
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"Historically in this patient population, median survival has been about six months, so this is a fourfold improvement," said Dr. Sattva Neelapu, co-leader of the Yescarta study and professor of lymphoma and myeloma at the University of Texas MD Anderson Cancer Center in Houston.
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Two decades later, reflecting on the possibility of a connection between his multiple myeloma and his son's leukemia, Stottlemyre thought back to radiation treatments he had received on his shoulder from the Yankees' team doctor in the late 1960s as a means of reducing calcification.
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The researchers found a positive association between diet soda and total aspartame intake and risks for non-Hodgkin lymphomas and multiple myeloma in men and leukemia in both men and women (why men appear to be more at risk is interesting, see this video for more).
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"We now know that Kyprolis not only significantly extended progression-free survival compared to Velcade, but also overall survival, making it a clinically meaningful advance in the treatment of relapsed or refractory multiple myeloma," Dr. Meletios Dimopoulos, one of the study's lead investigators, said in a statement.
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Patients in the Phase I dose-escalation study had received seven prior treatment regimens, including regimens with the newest multiple myeloma drugs, such as Johnson & Johnson's Darzalex, and had undergone at least one stem cell transplant before receiving bb2121, which is being co-developed with Celgene Corp.
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Because he still had a tiny percentage of myeloma cells in his bone marrow after an arduous autologous stem cell transplant, which uses the patient's own cells, he rejected the advice of specialists and underwent an allogeneic stem cell transplantation, using cells from a genetically matched person.
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Following the sudden death of her stepfather, who passed away five months after receiving a multiple myeloma diagnosis over a decade ago, the henna artist — who began practicing and ultimately mastering her craft in 2008 — was determined to use her artistic ability to better the lives of others.
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Long-term exposure (over the course of several years) to PERC also seems to be linked to several forms of cancer (like bladder cancer, non-Hodgkin lymphoma, and multiple myeloma), as well as damage to the central nervous system, kidneys, liver, lungs, and possibly the reproductive system and fetuses.
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The longtime host and producer at CityTV Santa Monica, a cable channel serving the Southern California city, she had kept it mostly to herself that her husband of 51 years, Norman Jacobson, had found out five years earlier that he had multiple myeloma, and he was losing ground.
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"The FDA determined data currently available from non-Opdivo studies indicate the risks of PD-1/PD-L1 treatment plus pomalidomide or lenalidomide and possibly PD-1/PD-L1 treatments alone or with other combinations outweigh potential benefit for patients with multiple myeloma," Bristol-Myers said on its website.
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The company caused a stir at the American Society of Hematology meeting in December with its CAR-T bb2121 as the therapy led to extremely high response and remission rates with good safety in a small study of heavily pretreated multiple myeloma patients who had run out of options.
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Together they have nine different drugs - six from Bristol-Myers and three from Celgene - with global sales of more than $1 billion each, led by $8.2 billion in sales for Revlimid, the Celgene drug used to treat multiple myeloma, a cancer that affects bone marrow and white blood cells.
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The F.D.A. reprimanded Celgene multiple times in those early years, telling the company that it had not adequately warned about thalidomide's risks in its announcement about multiple myeloma, and calling a meeting in December 1998 to warn of its "strong concern" that Celgene was marketing Thalomid for unapproved uses.
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The study is in Lancet Public Health Using five-year age cohorts, they found that for six of the 12 obesity-related cancers (multiple myeloma, colorectal, uterine, gallbladder, kidney and pancreatic) the risk for disease increased in adults 25 to 49, with the magnitude of the increases steeper with younger age.
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Doctors have leeway in deciding which drugs to prescribe, but pharmaceutical companies are supposed to promote their products only for uses that are approved by the F.D.A. Celgene did not gain approval to market Thalomid as a cancer treatment until 2006, when the F.D.A. cleared it to promote the drug for multiple myeloma.
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"It's the country's insular and homogeneous population of some 329,753 people that make it a great sample for genealogists and scientists to trace genetic mutations that can increase the risk of cancer," said Dr. Brian Durie, chairman and co-founder of the International Myeloma Foundation who is overseeing the so-called iStopMM project in Iceland.
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In one example, the study said that in the United States Takeda Pharmaceuticals sells Velcade, a drug for the treatment of multiple myeloma and lymphoma, only in 3.5-milligram vials that sell for $1,034 and hold enough medicine to treat a person who is 6 feet 13 inches tall and who weighs 250 pounds.
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When PEOPLE got an invitation to participate in the Empire State Building Run-Up sponsored by Turkish Airlines (which is headquartered there), I knew I couldn't pass up the opportunity to do one of the most iconic races in the world, one that benefits charities like the Challenged Athletes Foundation and the Multiple Myeloma Research Foundation.
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A group of renown medical researchers are front-running a project in Iceland backed by the IMF that aims to decipher the genetic codes for most of the population of the tiny island nation through screening to determine who is predisposed for multiple myeloma, a form of blood cancer that develops in the bone marrow, typically in older adults.
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This new review, published in The New England Journal of Medicine, links an additional eight cancers to excess fat: gastric cardia, a cancer of the part of the stomach closest to the esophagus; liver cancer; gallbladder cancer; pancreatic cancer; thyroid cancer; ovarian cancer; meningioma, a usually benign type of brain tumor; and multiple myeloma, a blood cancer.
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"We will trace what has happened from the time of the ancient Greeks, when 'good judgment' prevailed in society, to the 21st century, when technology has gained ascendance," Mr. Silman said in describing the course, which he taught through the spring semester, despite the debilitating effects of myelodysplastic syndrome, which was brought on by treatment for multiple myeloma.
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When Mr. Miller died in November, at 62, of complications of multiple myeloma, kidney failure and diabetes, Ms. Linna was left to ponder her life alone as well as the future of their sprawling business, which includes not only the label but a book publishing imprint and the tiny Norton Record Shop in Prospect Heights, Brooklyn.
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Now we're developing cell-based therapies that you and I were talking about beforehand, you know, CAR T for multiple myeloma, where we are actually going to have to extract cells, send them out to another area where we're going to adapt them and then re-administer them to the patient that you're actually going to be bringing about a cure.
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Mitchell, who has a cancer called multiple myeloma and is the founder of Patients for Affordable Drugs, has followed the development of CAR T and thinks gene therapy could be a game-changer for people in his position, but fears that the two companies offering CAR T, Novartis and Gilead, will keep it out of the hands of patients who need it.
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