The first application was the ability to see malignant growth through human tissue to identify early-stage breast cancer.
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LIMA (Reuters) - Uruguay's President Tabare Vazquez announced on Tuesday that doctors detected a likely malignant growth in his right lung during a routine checkup.
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It is unfortunate that this land, once a thriving melting pot, is now a nerve center for this robotic scourge that channels the Atacama's wind and sun to feed its uncontrollable and malignant growth.
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If a malignant growth can be detected before it's had the opportunity to become mobile, survival rates are very often better than 50-50 (based on a rough sampling of prognosis statistics), depending on the variety of cancer and the health of the patient.
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These results allow that BLT2 receptors may contribute to the malignant growth and metastasis of human pancreas cancer.
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Hoogs had his leg amputated in 1968, after developing a malignant growth on his foot. He died of cancer in 1978.
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A malignant growth was discovered in Buchanan's body sometime in August 1953 and he died on July 12, 1954, ten days after celebrating his 78th birthday.
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In consequence of the latter effect, the fusing protein continuously stimulates pro-growth and pro-survival pathways and thereby the malignant growth of its parent cells.
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Bcl11b (mouse analogue of human BCL11B) has been proven to contribute to malignant growth for example in case of mouse lymphomas. That is suspected to be caused by interaction with p53, a well-known tumor suppressor gene.
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Isaac Adler. "Primary Malignant Growth of the Lung and Bronchi". (1912) New York, Longmans, Green. pp. 3–12. Reprinted (1980) by A Cancer Journal for Clinicians Prior to World War I, lung cancer was a rare disease that most physicians never saw in their career.
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Gaucher's disease is a sphingolipidosis described by a particular inadequacy in acidic glucocerebrosidase, which results in abnormal gathering of glucosylceramide essentially inside the lysosome. Gaucher's disease has been associated with instances of leukemia, myeloma, glioblastoma, lung malignancy, and hepatocellular carcinoma, in spite of the fact that the explanations behind the relationship are at present being discussed. Some suggest that the impacts of Gaucher's disease might be connected to malignant growth, while others ensnare the treatments used to treat Gaucher's illness. This discussion is not completely astounding, as the theories connecting Gaucher's disease with cancer fail to address the roles of ceramide and glucosylceramide in malignant growth science.
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He was demitted in 1623. He moved to Paisley and was admitted on 1 January 1626. He demitted in August that year, having been assaulted. He retired to Trochrig, and died in Edinburgh (where he had gone for medical advice) of a malignant growth in the throat, 5 January 1627.
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Coffman died at home at the age of 51 on July 22, 1899. The cause of death was a malignant growth in his stomach, from which he had suffered for a number of years. Funeral services were held in both Elkhart and Virginia. He was buried at Prairie Street Cemetery.
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Historically there has been a close correlation between economic growth and environmental degradation: as communities grow, so the environment declines. This trend is clearly demonstrated on graphs of human population numbers, economic growth, and environmental indicators. Unsustainable economic growth has been starkly compared to the malignant growth of a cancerAbbey, E. (1968). Desert Solitaire.
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Radiotherapy can cause permanent hyposalivation due to injury to the oral mucosa containing the salivary glands, resulting in xerostomia, whereas chemotherapy may cause only temporary salivary impairment. Graft versus host disease after allogeneic bone marrow transplantation may manifest as dry mouth and many small mucoceles. Salivary gland tumours may occur, including mucoepidermoid carcinoma, a malignant growth.
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In December 1969, Saugestad was named the head football coach after Edor Nelson resigned the position. Saugestad was the head football coach during the 1970 and 1971 football seasons. From 1981 to 1987, he was also Augsburg's men's athletic director. In the fall of 1995, Saugestad's left kidney shut down, and he underwent six surgeries to diagnose and remove a non-malignant growth.
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In early April 2012, he began experiencing colic symptoms that led to a vet emergency visit. The exam performed by the veterinarian indicated a large pulsing mass in the rectal area, and the ultrasound revealed bleeding. The determination made was that he could no longer be saved from extreme pain and suffering given his age and the malignant growth so he was humanely euthanized.
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"Malignant Growth: The Ecology of the Troll." Dragon #301 (Paizo Publishing, 2002) Savage Species (2003) presented the troll as both a race and a playable class.Eckelberry, David, Rich Redman, and Jennifer Clarke Wilkes. Savage Species (Wizards of the Coast, 2003) The Forgotten Realms product Unapproachable East (2003) introduced the fell troll, the ice troll, the mur-zhagul (or demon troll), and the slime troll.
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Reprinted in English in the book On metabolism of tumors by O. Warburg, Publisher: Constable, London, 1930. He hypothesized that cancer, malignant growth, and tumor growth are caused by the fact that tumor cells mainly generate energy (as e.g., adenosine triphosphate / ATP) by non-oxidative breakdown of glucose (a process called glycolysis). This is in contrast to healthy cells which mainly generate energy from oxidative breakdown of pyruvate.
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On October 29, Norris announced he was cancer free following a successful surgery to remove a malignant growth from his thyroid. One of Norris' hobbies is photography. During the 2015 season, he acquired professional photographer Ben Moon's Canon EF 85mm portrait lens, and the two became friends. That offseason, the two went on a road trip together, from Norris' home state of Tennessee to Oregon, where Moon is based.
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A glossectomy is the surgical removal of all or part of the tongue. It is performed in order to curtail malignant growth such as oral cancer. Often only a portion of the tongue needs to be removed, in which case the procedure is called a partial removal, or hemiglossectomy. A midline glossectomy is a surgical reduction of the size of the base of the tongue (posterior tongue), sometimes used to treat sleep apnea.
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Salivary gland tumours usually present as a lump or swelling in the affected gland which may or may not have been present for a long time. The lump may be accompanied by symptoms of duct blockage (e.g. xerostomia). Usually, in their early stages it is not possible to distinguish a benign tumour from a malignant one. One of the key differentiating symptoms of a malignant growth is nerve involvement; for example, signs of facial nerve damage (e.g.
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The columnar epithelium ascending the esophagus from the stomach has subsequently become known as Barrett's oesophagus. In addition to his work on oesophageal disease, Barrett also worked with Leonard Dudgeon, Professor of Pathology at the University of London, on the cytology of sputum in the diagnosis of pulmonary malignancy.Barrett NR. Examination of sputum for malignant cells and particles of malignant growth. J Thorac Surg, 1938;8:169-83 He is also noted for his treatment of hydatid cysts.
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This creates a fusion gene of the oncogene category which encodes a chimeric protein that promotes the malignant growth of its parent cells. It may be unclear which portion of the newly formed oncoprotein contributes to the ensuing malignancy but fusions between ETV6 and proteins with tyrosine kinase activity generally are converted from a protein with tightly regulated tyrosine kinase activity to an uncontrolled and continuously active tyrosine kinase that thereby promotes the malignant transformation of its parent cells.
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Papillary urothelial neoplasm of low malignant potential (PUNLMP) is an exophytic (outward growing), (microscopically) nipple-shaped (or papillary) pre-malignant growth of the lining of the upper genitourinary tract (the urothelium), which includes the renal pelvis, ureters, urinary bladder and part of the urethra. PUNLMP is pronounced pun-lump, like the words pun and lump. As their name suggests, PUNLMPs are neoplasms, i.e. clonal cellular proliferations, that are thought to have a low probability of developing into urothelial cancer, i.e.
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It was Lucrezia at Her Majesty's on 19 May 1877. She had known for some time that her body harboured a malignant growth, and she gave this performance prior to undergoing a surgical procedure designed to ease her affliction. She was really too ill to go on, but insisted. After each of the acts she fainted and had to be resuscitated, but while on stage showed no sign of her physical suffering, and only a few in the audience knew her condition.
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Many proteins can exist in a cell in various locations, and the addition of a farnesyl group targets proteins to the plasma membrane. When ras gets to the plasma membrane, it becomes activated, and leads to tumour formation if this process is not stopped. It was thought that by inhibiting FT, ras will not be activated, therefore preventing cancer growth. The problem was that ras can also be modified by other mechanisms, and thus FTIs were not sufficient to inhibit malignant growth induced by ras signaling.
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The previous finding of RTVP1 (GLIPR1) as a p53 target gene with tumor suppressor functions prompted the researches to initiate a genome-wide sequence homology search for RTVP1/GLIPR1-like (GLIPR1L) genes. p53, the tumor suppressor gene is the most commonly mutated gene in human cancer. Mutation in p53 gene can lead to cellular malfunctions such as malignant growth and metsastatis. Human GLIPR1, was initially identified in human glioblastoma and was called as GLIPR1 (glioma pathogenesis-related protein 1) or RTVP1 (related to testes-specific, vespid, and pathogenesis protein 1).
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In religion, Douglass and her husband were members of the Unitarian Congregation of Meadville. For a few years, Douglass retired from active efforts in the temperance cause, owing to failing eye- sight. Cataracts formed on both of her eyes, and though they were removed, she only regained partial vision. In the winter of 1898–99, she had had a surgical operation for a malignant growth and had recovered almost completely from its effects, when a little more than a week before her death, she broke one of her legs.
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Either event can drive the malignant growth of cells but in most cases the chimeric protein's tyrosine kinase activity appears responsible for doing so. Based on a limited number of genetic studies (a total of 65 patients), the ETY6-NTRK3 fusion gene appears to occur in most cases of the cellular and some cases of the mixed but no cases of the classical types of congenital mesolastic nephroma. However, a more recent study of 19 patients detected the fused gene in all 8 cases of cellular, 5 of 6 cases of mixed, and 0 of 5 cases of classic mesoblastic nephroma.
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13(S)-HODE inhibits the proliferation and causes the death (apoptosis) of cultured human colon cancer cells. Animal model studies also find that the 15-lipoxygenase 1 / 13-HODE axis inhibits the development of drug-induced colon cancer as well as the growth of human colon cancer cell explants. These results suggest that 15-lipoxygenase 1 and its 13(S)-HODE product are factors in promoting genetically-associated and -non-associated colon cancers; they function by contributing to the suppression of the development and/or growth of this cancer and when reduced or absent allow its unrestrained, malignant growth.
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G2A was initially defined as one of the gene products whose production was stimulated in mouse pre-B lymphocytes (see Immunoglobulin heavy chain) by transfecting the cells with the human oncogene (i.e., cancer causing) BCR-ABL or by treating the cells with DNA damaging agents; its expression in these cells blocked their progression through the cell cycle specifically at the G2-M DNA damage checkpoint. These studies allow that G2A limits the potentially malignant growth of certain cells in mice and possible could do so in humans. In addition, Gene knockout studies in mice find G2A to be necessary for suppressing an autoimmune syndrome (see G2A deficiency in mice).
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She later moved to Pubna where there were tensions with other missionaries, particularly as the men, who had arrived later, controlled the finances and movements of the women. In 1912 she was instructed by the Australian society to "stop interfering in the Pubna men's department or come home." From 1913, she lived in a thatched, mud-floored village hut among the local people rather than in the typical British Raj style properties of her colleagues. Arnold retired to Australia in 1930, with the East Bengal Baptist Union taking over her work, but returned to India as a voluntary worker and died in Ataikola on 9 July 1931 after refusing surgery for a malignant growth.
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Human breast cancer often expresses and appears promoted by Ras proteins (see carcinogenesis and the Ras subfamily). The forced expression of oncogenic Ras in cultured human MCF-10A breast cancer cells markedly up- regulates BLT2 receptors and this up-regulation appears essential for the epithelial–mesenchymal transition-promoting ability of Transforming growth factor beta in these cells; BLT2 receptors in these cells appear to stimulate the production of reactive oxygen species and activation of NF-κB and may thereby contribute to the metastatic ability of breast cancer. Since BLT2 receptors are significantly elevated in human breast cancer tissue compared to non-cancerous breast tissue, the cited studies, when taken together, indicate that BLT2 receptors promote the malignant growth, invasiveness, metastasis and possibly anti-cancer drug resistance of not only cultured human breast cancer cells but also of human breast cancer.
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Targeted disruption of G2A in mice causes the development of a late onset (> 1 year) slowly progressive wasting and autoimmune disease characterized by lymphoid organ enlargement, lymphocytic infiltration into various tissues, glomerular immune complex deposition, and anti-nuclear autoantibodies. Mice transplanted with bone marrow cells containing the BCR-ABL leukemia-inducing fusion gene but deficient in G2A exhibit expanded populations of leukemic cells compared to recipients of BCR-ABL-containing, G2A-sufficient bone marrow cells. BCR-ABL is the oncogene of the Philadelphia chromosome that causes human Chronic myelogenous leukemia and is sometimes found associated with human acute lymphocytic leukemia and acute myelocytic leukemia; furthermore, the forced expression of BCR-ABL in cultured rodent cells induces the expression of G2A and the overexpression of G2A inhibits the malignant growth to these cells. Thus, the G2A deficiency studies suggest that G2A functions in mice to suppress certain immune dysfunctions and BCR-ABL-related leukemic cell growth.
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