164 Sentences With "cutis" | Random Sentence Generator

"I'm not here for you," Cutis said, addressing these men.

Baby William was re-diagnosed with a different rare disease, cutis aplasia.

Ja'bari was initially diagnosed with a rare skin condition called Aplasia Cutis.

When I removed the calcinosis cutis, we didn't use his voice in the video.

According to the Genetic and Rare Diseases Information Center, Aplasia Cutis is when someone is born without skin.

When I was growing up, there were all these issues of Cutis around the house — the skin cancer magazine.

Fosfomycin was first discovered in 1969 and has been used to treat a variety of serious bacterial infections including cUTIs in countries outside the United States.

"It seems to me, and correct me if I'm wrong, but virtually every case of voter fraud I can remember in my lifetime was committed by Democrats," Cutis said, according to an archived podcast on the station's website.

Nabriva Chief Executive Officer Ted Schroeder said side effects such as nausea and diarrhea that typically occur with the oral formulation of fosfomycin — sold as Monurol by Allergan Plc in the United States and which needs to be administered at higher doses to treat cUTIs — are not common with Contepo.

Membranous aplasia cutis is a cutaneous condition, a type of aplasia cutis congenita, which can be seen along the embryonic fusion lines of the face.

Cysticercosis cutis is a cutaneous condition caused by Taenia solium.

Papillomatosis cutis carcinoides (also known as "Gottron's carcinoid papillomatosis" and "Papillomatosis cutis carcinoides of Gottron–Eisenlohr") is a cutaneous condition characterized by verrucous skin lesions, and is due to an HPV infection of the skin.

"Ellis' muscle", the Corrugator cutis ani muscle, is named after him.

"Myrrys" - 5:00 :2. "The Black Keyes (of R'lyeh)" - 5:53 :3. "Metsänpeitto" - 0:58 :4. "Persona Mortuae Cutis" - 5:52 "Persona Mortuae Cutis" appears as a cover version of the Slayer song Dead Skin Mask translated to Latin.

Several symptoms are shared with cutis laxa type II (CLT2) including wrinkling of skin, microcephaly, and developmental delay which has made proper diagnosis difficult in several cases. However, the severity of skin abnormalities and facial dysmorphia is greater in cutis laxa type II.

The genus name Cuterebra is a blend of the Latin words cutis : skin and terebra : borer.

Usually observed at birth or shortly thereafter in 94% of patients, in other reports, patients did not develop skin lesions until 3 months or even 2 years after birth.Powel ST, Su WP. Cutis marmorata telangiectatica congenita: report of nine cases and review of the literature. Cutis. 1984 Sep;34(3):305-12. Review.Lee S, Lee JB, Kim JH, et al. Cutis marmorata telangiectatica congenita with multiple congenital anomalies (van Lohuizen’s syndrome). Dermatologica. 1981;163(5):408-12.

Mutations in this gene are a cause of both cutis laxa type II and wrinkly skin syndrome.

Plate-like osteoma cutis is a congenital condition characterized by firm papules and nodules on the skin.

The generic name derives from the Latin humidus "moist" and cutis "skin", referring to their moist caps.

Cutis marmorata telangiectatica congenita is a rare congenital vascular disorder that usually manifests in affecting the blood vessels of the skin. The condition was first recognised and described in 1922 by Cato van Lohuizen,Van Lohuizen CHJ. Cutis marmorata telangiectatica congenita,. Acta Derm Venereol. (Stockh). 1922:3:202-11.

Scalp–ear–nipple syndrome (also known as "Finlay–Marks syndrome") is a condition associated with aplasia cutis congenita.

Cutis rhomboidalis nuchae is a skin condition of the posterior neck, characterized by deep furrowing of the skin.

Hoya cutis-porcelana is an endemic species of porcelainflower or wax plant found in Biliran and Samar, Philippines is an Asclepiad species of flowering plant in the dogbane family Apocynaceae described in 2013 by W.Suarez, J.R.Sahagun & Aurigue. Hoya cutis-porcelana belongs to the genus Hoya. There are no subspecies listed.

Cutis marmorata telangiectatica congenita with gangrenous ulceration and hypovolaemic shock. Eur J Pediatr. 2005 Jul;164(7):411-3.

In dogs, calcinosis cutis is found in young, large breed dogs and is thought to occur after a traumatic injury.

Pileipellis type is an important character in the identification of fungi. Pileipellis types include the cutis, trichoderm, epithelium, and hymeniderm types.

A study by Leao-Teles et al. has shown that De Barsy syndrome may be related to mutations in ATP6V0A2 gene, known as ATP6V0A2-CDG by the new naming system. Alternative names for De Barsy syndrome include corneal clouding-cutis laxa-mental retardation, cutis laxa-growth deficiency syndrome, De Barsy–Moens–Diercks syndrome, and progeroid syndrome of De Barsy.

In contrast, the cap cuticle of H. aurantiaca is arranged as a uniformly tangled cutis (with hyphae parallel to the pileus surface).

The specific epithet, cutis-porcelana literally translate to porcelain skin, which refers to the porcelain-like appearance of the surface of the flowers.

Medical terminology for these kinds of markings includes striae atrophicae, vergetures, stria distensae, striae cutis distensae, lineae atrophicae, linea albicante, or simply striae.

Osteoma cutis is a cutaneous condition characterized by the presence of bone within the skin in the absence of a preexisting or associated lesion.

The stipitipellis is a cutis and can be set with cylindrical caulocystidia. Clamp connections are absent from hyphae in all parts of the fruit body.

Metastatic calcinosis cutis is a cutaneous condition characterized by calcification of the skin resulting from the deposition of calcium and phosphorus, and associated with an internal malignancy.

Leukemia cutis is the infiltration of neoplastic leukocytes or their precursors into the skin resulting in clinically identifiable cutaneous lesions. This condition may be contrasted with leukemids, which are skin lesions that occur with leukemia, but which are not related to leukemic cell infiltration. Leukemia cutis can occur in most forms of leukemia, including chronic myeloid leukemia, acute lymphoblastic leukemia, chronic lymphocytic leukemia, acute myeloid leukemia, and prolymphocytic leukemia.

They can have crystals incrusted at the apex. Cystidia are very important to separate species within this genus. Pileipellis is a trichoderm, sometimes a cutis. Hymenophoral trama parallel.

A cutis is a type of pileipellis characterized by hyphae that are repent, that is, that run parallel to the pileus surface. In an ixocutis, the hyphae are gelatinous.

The pileipellis is a cutis and clamp connections are present. Species in Corneriella are probably saprotrophs. Macroscopically, it resembles Tricholoma. Phylogenetically, it is closely related to Dennisiomyces and Albomagister.

Br J Dermatol. 2000 Feb;142(2):366-9. It should not be confused with the more general term "cutis marmorata", which refers to livedo reticularis caused by cold.

A small knob projects from the center of some of the pits. These pits are not openings of glands but have about the same structure as the pits seen in the head. The integumental bones in the Crocodilia originate in the connective tissue of the cutis. Investigations in young animals show that these bones usually take their origin in the under and middle layers of the cutis and generally work towards the periphery.

Adams–Oliver syndrome (AOS) is a rare congenital disorder characterized by defects of the scalp and cranium (cutis aplasia congenita), transverse defects of the limbs, and mottling of the skin.

SCARF syndrome is a rare syndrome characterized by skeletal abnormalities, cutis laxa, craniostenosis, ambiguous genitalia, psychomotor retardation, and facial abnormalities. It shares some features with Lenz-Majewski hyperostotic dwarfism syndrome.

Dystrophic calcinosis cutis is a cutaneous condition characterized by calcification of the skin resulting from the deposition of calcium and phosphorus, and occurs in a preexisting skin lesion of inflammatory process.

Cutis marmorata telangiectatica congenita is clinically similar, but the lesions are more intense, may be segmental, are persistent, and may be associated with loss of dermal tissue, epidermal atrophy and ulceration.

Xia-Gibbs Syndrome is associated with symptoms including global developmental delay, hypotonia, obstructive sleep apnea, seizures, retrocerebellar cyst, delayed myelination, thinned corpus callosum, cutis aplasia, cortical visual impairment, micrognathia and mild dysmorphic features.

Iatrogenic calcinosis cutis is a cutaneous condition characterized by calcification of the skin resulting from the deposition of calcium and phosphorus introduced by a medical procedure, either inadvertently or as a specific therapy.

Fewer than 100 cases of CMTC have been published worldwide. Petrozzi reported the first case of CMTC in the United States in 1970.Petrozzi JW, Rahn EK, Mofenson H, et al. Cutis marmorata telangiectatica congenita.

Hypotheses that have been proposed include: environmental/external factors;Amitai DB, Fichman S, Merlob P, et al. Cutis marmorata telangiectatica congenita: clinical findings in 85 patients. Ped Dermatol. 2000 Mar–Apr;17(2):100-4.

Focal facial dermal dysplasia is a rare genetically heterogeneous group of disorders that are characterized by congenital bilateral scar like facial lesions, with or without associated facial anomalies. It is characterized by hairless lesions with fingerprint like puckering of the skin, especially at the temples, due to alternating bands of dermal and epidermal atrophy. This condition is also known as Brauer syndrome (hereditary symmetrical aplastic nevi of temples, bitemporal aplasia cutis congenita, bitemporal aplasia cutis congenita: OMIM ) and Setleis syndrome (facial ectodermal dysplasia: OMIM ).

Traumatic calcinosis cutis is a cutaneous condition characterized by calcification of the skin resulting from the deposition of calcium and phosphorus often resulting from occupational exposure, as in cases reported in oil-field workers and coal miners.

Two key features of AOS are aplasia cutis congenita with or without underlying bony defects and terminal transverse limb defects. Cutis aplasia congenita is defined as missing skin over any area of the body at birth; in AOS skin aplasia occurs at the vertex of the skull. The size of the lesion is variable and may range from solitary round hairless patches to complete exposure of the cranial contents. There are also varying degrees of terminal limb defects (for example, shortened digits) of the upper extremities, lower extremities, or both.

Chloromas may occur in virtually any organ or tissue. The most common areas of involvement are the skin (also known as leukemia cutis) and the gums. Skin involvement typically appears as violaceous, raised, nontender plaques or nodules, which on biopsy are found to be infiltrated with myeloblasts Note that leukemia cutis differs from Sweet's syndrome, in which the skin is infiltrated by mature neutrophils in a paraneoplastic process. Gum involvement (gingival hypertrophy) leads to swollen, sometimes painful gums which bleed easily with tooth brushing and other minor trauma.

In 1908, what appears to be the first case of Urbach–Wiethe disease was reported by Friedrich Siebenmann, a professor of otolaryngology in Basel, Switzerland. In 1925, Friedrich Miescher, a Swiss dermatologist, reported on three similar patients. An official report of Urbach–Wiethe disease was first described in 1929 by a Viennese dermatologist and otorhinolaryngologist, Urbach and Wiethe. Its original name of 'lipoidosis cutis et mucosae' was changed to 'lipoid proteinosis cutis et mucosae' due to Urbach's belief that the condition was due to abnormal lipid and protein deposits within the tissues.

Patients with both missense and/or nonsense mutations of the ATP6V0A2 gene have been shown to phenotypically express wrinkly skin syndrome (WSS) or autosomal recessive cutis laxa type II (ARCL II) (another cutis laxa disorder). Some consider WSS to be a milder variant of ARCL II, but the genetic causes of WSS are not yet known. A large number of patients with WSS and ARCL II show a loss-of-function in the a2-subunit. These mutations in ATP6V0A2 are associated with defective glycan biosynthesis and defective Golgi apparatus structure.

Stipitipellis a cutis, hyphae 1.5–9.5 μm diameter, yellowish brown, thin-walled (up to 0.5–0.8 μm thick). Caulocystidia (19–) 22.5–49.5 (–56) × 4–8 (–9.5) μm, cylindrical, lageniform, fusiform or, utriform, or lageniform, hyaline and, thin-walled.

Lomholt H, Thestrup-Pedersen K. Paraneoplastic skin manifestations of lung cancer. Acta Derm Venereol. May 2000;80(3):200-2.Olsen TG, Milroy SK, Jones-Olsen S. Erythema gyratum repens with associated squamous cell carcinoma of the lung. Cutis.

Rosenthal–Kloepfer syndrome, is a cutaneous condition characterized by abnormal growth of bone and skin, coupled with clouding of the cornea. It was described in 1962. Another name for the condition is Acromegaly-cutis verticis gyrata-corneal leukoma syndrome.

It is characterized by ulcers. Diagnosis of amebiasis cutis calls for high degree of clinical suspicion. This needs to be backed with demonstration of trophozoites from lesions. Unless an early diagnosis can be made such patients can suffer from significant morbidity.

Cortinariaceae is a family of mushrooms within the Order Agaricales. The spore producing hymenium is located on the gills. The pileipellis is a cutis. The spores are brown in deposit and, in most genera in this family, the spores are ornamented.

Tuberculosis cutis orificialis (also known as "acute tuberculous ulcer") is a form of cutaneous tuberculosis that occurs at the mucocutaneous borders of the nose, mouth, anus, urinary meatus, and vagina, and on the mucous membrane of the mouth or tongue.

Tenericutes (tener cutis: soft skin) is a phylum of bacteria that contains the class Mollicutes. The name was validated in 1984 as a new division (phylum).Validation of the Publication of New Names and New Combinations ... Int. J. of Sust. Bact.

Neuroma cutis is a relatively rare type of neuroma, or tumor involving nervous tissue, in the skin. There are three types of true neuromas of the skin and mucous membranes known to exist: traumatic neuromas, multiple mucosal neuromas, and solitary palisaded encapsulated neuromas.

Deletions and mutations in this gene are associated with supravalvular aortic stenosis (SVAS) and the autosomal dominant cutis laxa. Other associated defects in elastin include Marfan syndrome, emphysema caused by α1-antitrypsin deficiency, atherosclerosis, Buschke-Ollendorff syndrome, Menkes syndrome, pseudoxanthoma elasticum, and Williams syndrome.

The spores are smooth, ellipsoid to ellipsoid-oblong, thin-walled and amyloid. Cheilocystidia are rare to absent and pleurocystidia are absent. The pileipellis is a cutis and clamp connections are present. Species in Pseudotricholoma are found on soil in grasslands and woods in the Northern Hemisphere.

Skeletal-binding hyphae are arboriform, and hyaline. The cap cuticle comprises a cutis made of hyaline to brown agglutinated and parallel generative hyphae. These are distinct from the contextual hyphae, which largely comprise non-agglutinated skeletal-binding hyphae. The basidia are club-shaped, with four sterigmata.

It can also be observed in various hereditary connective tissue disorders, including classical Ehlers- Danlos syndrome and cutis laxa. Dermatochalasis can be a major contributing factor for headaches due to tonic reflex contraction of muscles in an attempt to compensate, which then causes tension-type headaches.

Neutrophilic eccrine hidradenitis: a case report and review of the literature. Margolis DJ, Gross PR. Cutis. 1991;48(3):198-200.Imatinib mesylate and dermatology part 2: a review of the cutaneous side effects of imatinib mesylate. Scheinfeld N. J Drugs Dermatol. 2006 Mar;5(3):228-31.

Mazereeuw-Hautier J, Carel-Caneppele S, Bonafe JL. Cutis marmorata telangiectatica congenita: report of two persistent cases. Ped Dermatol. 2002 Nov–Dec;19(6): 506–9. When ulcers develop secondary to the congenital disease, antibiotic treatment such as oxacillin and gentamicin administered for 10 days has been prescribed.

18, 18.98-18. 106.Meena N, Saxena AK, Sinha S, Dixit N. Aplasia cutis congenita with fetus papyraceus. Indian J Paediatr Dermatol 2015;16:48-9. It is the most common congenital cicatricial alopecia, and is a congenital focal absence of epidermis with or without evidence of other layers of the skin.

Meena N, Saxena AK, Sinha S, Dixit N. Aplasia cutis congenita with fetus papyraceus. Indian J Paediatr Dermatol 2015;16:48-9. It can be associated with Johanson-Blizzard syndrome, Adams-Oliver syndrome, trisomy 13, and Wolf-Hirschhorn syndrome. It can also seen with exposure to methimazole and carbimazole in utero.

Arch Dermatol. 1970 Jan;101(1):74-7. CMTC is believed to be more common than suspected, as studies have shown that milder forms of the disease are not being recognized as CMTC.Torrelo A, Zambrano A, Happle R. Cutis marmorata telangiectatica congenita and extensive mongolian spots: type 5 phacomatosis pigmentovascularis.

Lenz–Majewski syndrome (LMS), also known as Lenz–Majewski hyperostotic dwarfism (LMHD), is a skin condition characterized by hyperostosis, craniodiaphyseal dysplasia, dwarfism, cutis laxa, proximal symphalangism, syndactyly, brachydactyly, mental retardation, enamel hypoplasia and hypertelorism.James, William; Berger, Timothy; Elston, Dirk (2005). Andrews' Diseases of the Skin: Clinical Dermatology. (10th ed.). Saunders. .

Skin features of amyloidosis cutis dyschromica. Hyperpigmented and hypopigmented macules on (A) lower legs, (B) back and waist, (C) waist. (D) Individual blisters on upper arm The presentation of amyloidosis is broad and depends on the site of amyloid accumulation. The kidney and heart are the most common organs involved.

Dystrophic calcinosis cutis has also been reported. Other serious sequelae include sialolithiasis of the submandibular gland and adenolymphoma of the parotid gland. The histopathology of fiddler's neck frequently shows hyperkeratosis and acanthosis, along with plugging of follicles. Histiocytic infiltration with granulomas to foreign body and follicular cysts are also common.

"Vacuolar H+-ATPase meets glycosylation in patients with cutis laxa." Biochimica et Biophysica Acta (BBA)-Molecular Basis of Disease 1792.9 (2009): 903-914. Vacuolar ATPases are also localized within the plasma membrane of both renal cells and osteoclasts. In osteoclasts, V-ATPases are required for pumping protons onto the bone surface.

The spores are pale brown, elliptical to slightly almond-shaped with minute, well-separated warts on the surface, and measure 8.5–11 by 5.5–6.5 μm. The cap cuticle is in the form of a cutis (with hyphae that run parallel to the cap surface); the hyphae measure 3–8 μm wide.

Subepidermal calcified nodule is a type of Calcinosis cutis, its a cutaneous condition characterized by calcification of the skin resulting from the deposition of calcium and phosphorus, occurring most frequently as one or a few skin lesions on the scalp or face of children. Lesions may also appear on the ear and eyelid.

Occipital horn syndrome (sometimes called X-linked cutis laxa or Ehlers-Danlos type 9) is a mild form of Menkes syndrome that begins in early to middle childhood. It is characterized by calcium deposits in a bone at the base of the skull (occipital bone), coarse hair, and loose skin and joints.

Several disorders share some characteristics with EDS. For example, in cutis laxa, the skin is loose, hanging, and wrinkled. In EDS, the skin can be pulled away from the body, but is elastic and returns to normal when let go. In Marfan syndrome, the joints are very mobile and similar cardiovascular complications occur.

Signs and symptoms of Beare–Stevenson cutis gyrata syndrome can include a blockage of the nasal passages (choanal atresia), overgrowth of the umbilical stump, and abnormalities of the genitalia and anus. The medical complications associated with this condition are often severe and may well be life-threatening in infancy or early childhood.

UMass Amherst. He conducted double blind studies and published his findings. One of his many awards was from the journal Cutis in March 1972 for his manuscript co-authored with Dr. V. A. Cecilioni on Chizzola Maculae, describing the skin lesion as a diagnostic tool for the identification of chronic fluoride poisoning.ibid.Chizzola Maculae.

Flowchart for use in scalp reconstruction.Main reasons for scalp reconstruction are divided into two groups: congenital or acquired. Congenital defects may include aplasia cutis congenita, congenital nevus, congenital vascular malformations and congenital tumors. Acquired defects can be caused by burns, blunt, penetrating, or avulsion injuries, tumor invasion, infection, oncologic resection, radiation, or wound-healing difficulties.

It has a marbled bluish to deep-purple appearance. The dark skin lesions often show a palpable loss of dermal substance. The reticulated mottling frequently appears more prominent in a cold environment (physiologic cutis marmorata), but tends not to disappear with warming. Hence, the erythema may be worsened by cooling, physical activity, or crying.

Dermatosis papulosa nigra (DPN) is a condition of many small, benign skin lesions on the face, a condition generally presenting on dark-skinned individuals. DPN is extremely common, affecting up to 30% of Black people in the US.Grimes PE, Arora S, Minus HR, Kenney JA Jr. Dermatosis papulosa nigra. Cutis. Oct 1983;32(4):385-6, 392.

Actinic elastosis usually appears as thickened, dry, wrinkled skin. Several clinical variants have been recorded. One of the most readily identifiable is the thickened, deeply fissured skin seen on the back of the chronically sun-exposed neck, known as cutis rhomboidalis nuchae. These features are a part of the constellation of changes that are seen in photoaged skin.

Spores are cylindrical to navicular (boat- shaped), thin-walled, smooth, and hyaline. Favolus differs from Neofavolus in the features of the cap surface. In Neofavolus, it is smooth to scaly, with a cutis made of hyaline to brown, parallel and agglutinated, generative hyphae that are distinct from contextual hyphae, which mainly comprise non- agglutinated skeletal-binding hyphae.

The cap cuticle is made of a trichoderm (a cellular arrangement wherein the outermost hyphae emerge roughly parallel, like hairs, perpendicular to the cap surface) in the middle part of the cap, and a cutis (where hyphae run parallel to the cap surface) at the cap margin. The intense orange color of the fruitbodies is caused by boletocrocin pigments.

C.Pathak) Vizzini & Contu, both pleurocystidia and cheilocystidia are completely absent. The cap cuticle (pileipellis) is an ixocutis (parallel hyphae embedded in a gelatinous matrix). The stipe cuticle (stipitipellis) is a cutis (parallel hyphae not embedded in a gelatinous matrix). Caulocystidia (cystidia on the cap) are sometimes present; they measure 65–140 by 10–25 μm, and are mostly cylindrical.

The lines were first discovered in 1861 by Austrian anatomist Karl Langer (1819-1887),Karl Langer, "Zur Anatomie und Physiologie der Haut. Über die Spaltbarkeit der Cutis". Sitzungsbericht der Mathematisch-naturwissenschaftlichen Classe der Wiener Kaiserlichen Academie der Wissenschaften Abt. 44 (1861) though he cited the surgeon Baron Dupuytren as being the first to recognise the phenomenon.

Rowley authored a chapter in Patriotism, Democracy, and Common Sense: Restoring America's Promise at Home and Abroad. edited by Alan Cutis and Kevin Phillip (Rowman & Littlefield Publishers, 2005, 496 pages, ). She has been a regular contributor at The Huffington Post since January 2006Coleen Rowley The Huffington Post. undated, retrieved 29 September 2015 and Rowley has written for The Guardian.

The Strophariaceae are a family of fungi in the order Agaricales. Under an older classification, the family covered 18 genera and 1316 species. The species of Strophariaceae have red-brown to dark brown spore prints, while the spores themselves are smooth and have an apical germ pore. These agarics are also characterized by having a cutis-type pileipellis.

De Barsy syndrome is a rare autosomal recessive genetic disorder. Symptoms include cutis laxa (loose hanging skin) as well as other eye, musculoskeletal, and neurological abnormalities. It is usually progressive, manifesting side effects that can include clouded corneas, cataracts, short stature, dystonia, or progeria (premature aging). It was first described in 1967 by De Barsy et al.

The cap cuticle is a cutis with prostrate hyphae. The scales are a trichoderm with septate hyphae 7.2 to 23.5 μm in diameter, with clamp connections and yellowish brown pigment encrusted in bands. Pileocystidia are absent. Caulocystidia are narrowly lageniform to narrowly utriform, 31 - 44 x 5.6 - 11 μm, with a 3 - 7 μm capitate to subcapitate apex.

The hyphae below the pileipellis run parallel to one another and measure between 4 and 8 μm in width. Their yellowish-brown pigment stains orange-brown in potassium hydroxide. The stipitipellis, the uppermost layer of hyphae on the stem, also forms a cutis. The cylindrical hyphae run parallel to one another and have thick cell walls.

Inocybe salicis mushrooms have tawny to yellowish-brown caps of between in diameter. Their surface can be cracked, covered in fibres or scaly. The caps change in shape as the mushrooms mature; while younger specimens have campanulate (bell-shaped) to conical caps, the caps of older specimens expand and flatten, with a broad umbo emerging. The cap cuticle forms a cutis.

There are no cheilocystidia nor pleurocystidia on the gills (cystidia on the edge and face of gills, respectively). The cuticle is a trichoderm observed on not weathered specimens, or a cutis with suberect to cylindrical hyphae (5–12 µm diameter), terminal cells fusoid, membrane thin-walled, not gelatinized, with blue-brownish pigment in the cytoplasm. Clamp connections are present in the hyphae.

Associated abnormalities include the following: • Body asymmetry (extremities; macrocephaly) • Glaucoma • Cutaneous atrophy • Neurological anomalies • Vascular anomalies (nevus flammeus /Sturge-Weber/Klippel-Trénauna Adams Oliver syndrome) • Psychomotor and/or mental retardation • Chronic ulceration that can complicate long-term CMTC • Chronic urticaria.Melani L, Antiga E, Torchia D, et al. Cutis marmorata telangiectatica congenita and chronic autoimmune urticaria in a young man. J Dermatol.

280px Calcinosis cutis is a type of calcinosis wherein calcium deposits form in the skin. A variety of factors can result in this condition. The most common source is dystrophic calcification, which occurs in soft tissue as a response to injury. In addition, calcinosis is seen in Limited Cutaneous Systemic Sclerosis, also known as CREST syndrome (the "C" in CREST).

Leukemids (also known as "Nonspecific cutaneous conditions associated with leukemia") are nonspecific skin lesions that occur with leukemia which are not related to leukemic cell infiltration. This condition may be contrasted with leukemia cutis, which is the infiltration of neoplastic leukocytes or their precursors into the skin resulting in clinically identifiable cutaneous lesions. The term dates back to at least 1915.

Reynolds syndrome is a rare secondary laminopathy, consisting of the combination of primary biliary cirrhosis and progressive systemic sclerosis. In some patients this syndrome has also been associated with Sjögren's syndrome and hemolytic anemia. Typical clinical features include jaundice, elevated blood levels of alkaline phosphatase, calcinosis cutis, telangiectasias, and pruritus. This disease may cause white or yellow-ish spots on the arms or legs.

There are two general types of skin, hairy and glabrous skin (hairless). The adjective cutaneous literally means "of the skin" (from Latin cutis, skin). Because it interfaces with the environment, skin plays an important immunity role in protecting the body against pathogens and excessive water loss. Its other functions are insulation, temperature regulation, sensation, synthesis of vitamin D, and the protection of vitamin B folates.

This can lead to significant scarring, changes in the affected person's skin pigmentation, and a cyclic worsening of the affected person's anxiety about their appearance. Rare complications from acne or its treatment include the formation of pyogenic granulomas, osteoma cutis, and acne with facial edema. Early and aggressive treatment of acne is advocated by some in the medical community to reduce the chances of these poor outcomes.

Xeroderma, xerosis or xerosis cutis, or simply dry skin, is a skin condition characterized by excessively dry skin. The medical term xeroderma is derived from the Greek words meaning dry skin. In most cases, dry skin can safely be treated with emollients or moisturizers. Xeroderma occurs most commonly on the scalp, lower legs, arms, hands, the knuckles, the sides of the abdomen, and thighs.

Dermatosis papulosa nigra (DPN) is a condition of many small, benign skin lesions on the face, a condition generally presenting on dark-skinned individuals. DPN is extremely common, affecting up to 30% of Black people in the US.Grimes PE, Arora S, Minus HR, Kenney JA Jr. Dermatosis papulosa nigra. Cutis. Oct 1983;32(4):385-6, 392. From a histological perspective, DPN resembles seborrheic keratoses.

Patterson syndrome is characterized by the patient's having an unusual facial look, similar to that caused by Leprechaunism. It primarily affects the connective tissue and the neuroendocrine system, giving rise to bronzed hyperpigmentation, cutis laxa of the hands and feet, bodily disproportion, intellectual disability, and major bony deformities. Radiographs reveal a characteristic generalised skeletal dysplasia. It comprises endocrine abnormality, hyperadrenocorticism, cushingoid features, and diabetes mellitus.

Aplasia cutis congenita is a rare disorder characterized by congenital absence of skin. Frieden classified ACC in 1986 into 9 groups on the basis of location of the lesions and associated congenital anomalies.Moss C, Shahidulla H. Naevi and other developmental defects. In: Burns T, Breathnach S, Cox N, Griffiths C, editors. Rook’s Textbook of Dermatology. 8th ed. United Kingdom (UK): Wiley-Blackwell Publication; 2010. p. 18, 18.98-18. 106.

It has (rarely) been associated with congenital defects, including aplasia cutis of the neonate but is not contra- indicated. However, it more predictably may cause fetal hypothyroidism so (in minimal doses) it can be used in order to control maternal hyperthyroidism. There are reported cases of goiter and choanal atresia in fetus. Furthermore, breast feeding is possible but only if lowest effective dose is used and neonatal development is closely monitored.

Other relatively rare conditions have been reported in association with this disease. It is not yet known if these associations are fortuitous or manifestations of the condition itself. Cerebral cavernomas and massive, macronodular adrenocortical disease have also been reported in association with this syndrome. A case of cutis verticis gyrata, disseminated collagenoma and Charcot-Marie-Tooth disease in association with a mutation in the fumarate hydratase gene has also been reported.

The subcutaneous tissue (also hypodermis and subcutis) is not part of the skin, but lies below the dermis of the cutis. Its purpose is to attach the skin to underlying bone and muscle as well as supplying it with blood vessels and nerves. It consists of loose connective tissue, adipose tissue and elastin. The main cell types are fibroblasts, macrophages and adipocytes (subcutaneous tissue contains 50% of body fat).

In cases of advanced disease, individuals with DS-AMKL may present with signs and symptoms that are more typical of acute myeloid leukemic diseases such as liver enlargement, spleen enlargement, leukemia cutis (i.e. skin nodules caused by leukemic infiltrates), or leukostasis (i.e. an emergency situation in which excessive elevations in circulating blast (i.e. early precursor) cells plug the microcirculation to cause life- threatening heart, lung, and neurological dysfunctions).

Papuloerythroderma of Ofuji is a rare disorder most commonly found in Japan, characterized by pruritic papules that spare the skinfolds, producing bands of uninvolved cutis, creating the so-called deck-chair sign. Frequently there is associated blood eosinophilia. Skin biopsies reveal a dense lymphohistiocytic infiltrate, eosinophils in the papillary dermis, and increased Langerhans cells (S-100 positive). Systemic steroids are the treatment of choice and may result in long-term remissions.

There are some cystidia scattered in the hymenium, and they measure 20–33 by 3–5 μm. On the gill edge, the cheilocystidia are arranged in clusters; they are club-shaped to egg-shaped, and measure 30–65 by 4–12 μm. The cap cuticle is made of hyphae arranged in a cutis (with hyphae that run parallel to the cap surface) measuring 4–10 μm in diameter.

Individuals with AOS may have mild growth deficiency, with height in the low-normal percentiles. The skin is frequently observed to have a mottled appearance (cutis marmorata telangiectatica congenita). Other congenital anomalies, including cardiovascular malformations, cleft lip and/or palate, abnormal renal system, and neurologic disorders manifesting as seizure disorders and developmental delay are sometimes observed. Variable defects in blood vessels have been described, including hypoplastic aortic arch, middle cerebral artery, pulmonary arteries.

This disorder was recognized as a distinct syndrome in 1997 and named macrocephaly-cutis marmorata telangiectasia congenita or M-CMTC. A new name, macrocephaly-capillary malformation, abbreviated M-CM, was recommended in 2007. This new name was chosen to more accurately describe the skin markings associated with this disorder. In January 2012, a paper proposed new names for the syndrome: megalencephaly- capillary malformation or megalencephaly-capillary malformation-polymicrogyria with an abbreviation of MCAP.

Hallucinogenic species typically have a blue-staining reaction when the fruit body is bruised. Microscopically, they are characterized by pileipellis with hyphae that run parallel to the pileus surface, forming a cutis, by their lack of chrysocystidia, and by spores that are smooth, ellipsoid to rhomboid to subhexagonal in shape, with a distinct apical germ pore. Ecologically, all species of Psilocybe are saprotrophs, growing on various kinds of decaying organic matter.Guzmán (1983), p. 22.

The yellowish hyphae are between 15 and 13.5 μm wide with a wall of variable thickness. There are clamp connections at the septa (the walls dividing individual hypha cells). The flesh in the cap is radial, and is made up of yellowish hyphae of between 2.4 and 20 μm wide. The pileipellis, the outermost layer of hyphae, forms a cutis, and on older specimens (and on the small scales) forms a trichoderm.

Cases of the disease not associated with mediastinal germ cell tumors occur in adults who as a group have older median age centering around those 50–70 years old. The disorder is far more fulminant than non-DS-AMKL and DS-AMKL and generally presents with more serious hematological symptoms (e.g. anemia- related) and a much higher incidence of extramedullary manifestations (e.g. organ enlargement, leukemia cutis) than seen in the other two forms of AMKL.

The term mycoplasma ( meaning fungus, and , meaning formed) is derived from the fungal-like growth of some mycoplasma species. The mycoplasmas were classified as Mollicutes (“mollis”, meaning soft and “cutis”, meaning skin) in 1960 due to their small size and genome, lack of cell wall, low G+C content and unusual nutritional needs. M. pneumoniae has also been designated as an arginine nonfermenting species. Mycoplasmas are further classified by the sequence composition of 16s rRNA.

The skin is involved about 10% of the time in the form of leukemia cutis. Rarely, Sweet's syndrome, a paraneoplastic inflammation of the skin, can occur with AML. Some people with AML may experience swelling of the gums because of infiltration of leukemic cells into the gum tissue. Rarely, the first sign of leukemia may be the development of a solid leukemic mass or tumor outside of the bone marrow, called a chloroma.

The cap cuticle is arranged in the form of a cutis—with hyphae that run parallel to the cap surface. Several chemical tests can be used to help verify an identification of L. holopus. A drop of ammonium hydroxide solution turns the cap cuticle a pinkish color, but has no reaction with the flesh. A drop of dilute potassium hydroxide (KOH) has no reaction on the cap surface, and either no reaction or a brownish reaction with the flesh.

As with ordinary celiac disease, IgA against transglutaminase disappears (often within months) when patients eliminate gluten from their diet. Thus, for both groups of patients, it may be necessary to restart gluten for several weeks before testing may be done reliably. In 2010, Cutis reported an eruption labelled gluten-sensitive dermatitis which is clinically indistinguishable from dermatitis herpetiformis, but lacks the IgA connection, similar to gastrointestinal symptoms mimicking coeliac disease but without the diagnostic immunological markers.

The cap cuticle is a cutis (a type of tissue where the hyphae are arranged more or less parallel to the surface), formed by hyphae with septa, roughly 4–9 μm in diameter. Clamp connections are present in the hyphae. The sclerotium is made of hyphae that have yellow pigment in their walls that appear in cross-section to be pseudoparenchymatous (compactly interwoven short-celled hyphae that resemble parenchyma of higher plants), and measure 5–10 μm in diameter.

The fruit body of Agaricus deserticola can grow up to in height. Fresh specimens are usually white, but will age to a pale tan; dried fruit bodies are light gray or tan mixed with some yellow. The cap is in diameter, initially conic, later becoming convex to broadly convex as it matures. The cap is composed of three distinct tissue layers: an outer volval layer, a middle cuticular layer (cutis), and an inner (tramal) layer which supports the gleba.

People with visible marks generally feel fine (physically) and can act normally, but when it is mentioned, they may become withdrawn and self-conscious. Some children may have low self-esteem due to the condition.CMTC is an uncommon, sporadic congenital vascular malformation characterized by a generalized or localized reticulated cutaneous vascular network. Cutaneous lesions described in patients with CMTC include nevus flammeus, hemangioma, nevus anemicus, café- au-lait spots, melanocytic nevus, aplasia cutis and acral cyanosis.

3D animation of a subcutaneous injection A subcutaneous injection is administered as a bolus into the subcutis, the layer of skin directly below the dermis and epidermis, collectively referred to as the cutis. Subcutaneous injections are highly effective in administering medications such as insulin, morphine, diacetylmorphine and goserelin. Subcutaneous (as opposed to intravenous) injection of recreational drugs is referred to as "skin popping." Subcutaneous administration may be abbreviated as SC, SQ, sub-cu, sub-Q, SubQ, or subcut.

Calendar of events, Canada-Ukraine Chamber of Commerce In 2016, Global Affairs Canada established the Canada-Ukraine Trade and Investment Support (CUTIS) Project, which is budgeted for five years and was designed "to lower poverty in Ukraine through increasing exports from Ukraine to Canada and investment from Canada to Ukraine". Canadian non-governmental organizations also have substantially provided aid to the Ukrainian army and set up rehabilitation clinics for Ukrainian soldiers during the War in Donbass.

Xenopus embryos have also provided a rapid test bed for validating newly discovered disease genes. For example, studies in Xenopus confirmed and elucidated the role of PYCR1 in cutis laxa with progeroid features. Transgenic Xenopus for studying transcriptional regulation of human disease genes: Xenopus embryos develop rapidly, so transgenesis in Xenopus is a rapid and effective method for analyzing genomic regulatory sequences. In a recent study, mutations in the SMAD7 locus were revealed to associate with human colorectal cancer.

Dr. med. Gustav Riehl Professorenkatalog der Universität Leipzig He made contributions in his work involving skin tuberculosis, severe burn therapy, leishmaniasis, mycosis fungoides, radiation therapy, et al. In 1886, with Richard Paltauf, he described tuberculosis verrucosa cutis,Dermatology by Otto Braun-Falco, Gerd Plewig, Helmut H. Wolff, Richard K. Winkelmann and in 1917 described a type of hyperpigmentation known today as Riehl melanosis.Civatte's syndrome at Who Named It At Vienna General Hospital he established a radiation treatment ward.

The hyphae typically have fairly thin, smooth walls, but they can have a small amount of brown pigment, which stains orange-brown in potassium hydroxide. The pileipellis, the uppermost layer of hyphae in the cap, forms a cutis made up of cylindrical, slightly thicker-walled hyphae of between 5 and 10 μm wide. They can be interwoven or primarily extending from the margin to the centre. The pigmentation is yellowish-brown and stains reddish-brown in potassium hydroxide.

The dermis or corium is a layer of skin between the epidermis (with which it makes up the cutis) and subcutaneous tissues, that primarily consists of dense irregular connective tissue and cushions the body from stress and strain. It is divided into two layers, the superficial area adjacent to the epidermis called the papillary region and a deep thicker area known as the reticular dermis.James, William; Berger, Timothy; Elston, Dirk (2005). Andrews' Diseases of the Skin: Clinical Dermatology (10th ed.). Saunders.

The genus was circumscribed by Czech mycologists František Kotlába and Zdeněk Pouzar in 1958 with Skeletocutis amorpha (originally described as Polyporus amorphus by Elias Magnus Fries in 1815) as the type and only species. The generic name Skeletocutis is derived from the Ancient Greek word (skeleto, "dried up") and the Latin word cutis ("skin"). Other genera that feature encrustations in the hyphae of the dissepiment edges include Tyromyces and Piloporia. Molecular analyses has shown the close phylogenetic relationship between Skeletocutis and Tyromyces.

The cause of Grover's disease is unknown. Suspected triggers of disease activity include heat and sweating, sunlight, and adverse reaction to medications as well as ionizing radiation, end-stage renal disease/hemodialysis, and mechanical irritation or prolonged bed rest. Some cases of Grover's disease have been associated with medications such as sulfadoxine-pyrimethamine, ribavirin, cetuximab, and interleukin-4 [1,8-15]. One series of 300 patients with Grover's disease reported an association with other coexisting dermatoses including atopic dermatitis, contact dermatitis, and xerosis cutis.

The disorder is primarily associated with eye, skin, and cranial nerve symptoms with the onset of symptoms appearing between the thirties and fifties. The most common characteristic is type II lattice corneal dystrophy with other signs such as polyneuropathy, dermatochalasis, open-angle glaucoma, bilateral progressive facial paralysis, cutis laxa, skin fragility with ecchymosis, facial mask, diffuse hair loss, dry skin, bilateral tunnel syndrome, nephrotic syndrome, cardiomyopathy with conduction alterations, and early aging associated with the condition. There are no specific treatments available.

Von Zumbusch psoriasis is named after the German dermatologist Leo Ritter von Zumbusch (1874-1940), son of Kaspar von Zumbusch, who described the first documented case of generalized pustular psoriasis in the early 1900s. See Case Report #1. Sometimes all or any of GPP is referred to as von Zumbusch psoriasis, but in the literature it is often distinguished as one specific form of GPP. Eugene M. Farber, MD and colleagues provide a description of von Zumbusch psoriasis in "Pustular Psoriasis", published in Cutis.

Rhodophana is distinguished from other genera of the Entolomataceae because there are clamp connections and based on the structure of the cap skin. This genus has a thin outer cutis in a single layer merging into the main trama whilst other family members have a two-layer cap skin. The type species is Rhodophana nitellina. The name is derived from "rhodon" (ῥόδον) = "rose" (referring to the pink colour of the spores and gills) and "phanos" (φανός) = bright or conspicuous (referring to the cap colour).

Mutations in COX7B have been associated with linear skin defects with multiple congenital anomalies. This disorder is a distinct form of aplasia cutis congenita presenting as multiple linear skin defects on the face and neck associated with poor growth and short stature, microcephaly, and facial dysmorphism. Additional clinical features include intellectual disability, nail dystrophy, cardiac abnormalities, diaphragmatic hernia, genitourinary abnormalities, pale optic discs and altered visual-evoked potentials, agenesis of the corpus callosum, and other central nervous system abnormalities. The COX7B mutations associated with disease include c.

Hereditary gelsolin amyloidosis has originally been reported by Finnish ophthalmologist Jouko Meretoja and is known as Meretoja syndrome or Familial Amyloidosis, Finnish type.Kiuru S. (1998) Gelsolin-related familial amyloidosis, Finnish type (FAF), and its variants found worldwide. Amyloid. 5(1):55–66. In addition to the classic manifestations of Finnish type Familial Amyloidosis, cutis laxa, progressive peripheral neuropathy and corneal lattice dystrophy, some of the afflicted members of the Iranian family have retinitis pigmentosa. This feature had not been previously reported with this type of amyloidosis.

Cutis marmorata (from Latin marmor, "marble") is a benign skin condition which, if persistent, occurs in Cornelia de Lange syndrome, trisomy 13 and trisomy 18 syndromes. When a newborn infant is exposed to low environmental temperatures, an evanescent, lacy, reticulated red and/or blue cutaneous vascular pattern appears over most of the body surface. This vascular change represents an accentuated physiologic vasomotor response that disappears with increasing age, although it is sometimes discernible even in older children. It is also seen in cardiogenic shock.

Cutis marmorata also occurs in decompression sickness (DCS). Although it is considered Type I DCS, which is non-neurological, it is typically treated as if the patient has the more severe Type II DCS. This is because past experience in diving medicine has shown that patients initially presented with only this symptom have a high likelihood of progression to neurological, Type II, DCS without prompt treatment. The marbling does not resolve until few days after treatment, but any pruritus (itching) will likely disappear upon initial recompression.

The leading symptoms of Transaldolase Deficiency are coagulopathy, thrombocytopenia, hepatosplenomegaly, hepatic fibrosis and dysmorphic features. The dysmorphic features can include antimongoloid slant, low-set ears, and cutis laxa. Those affected by this disease have abnormal polyol concentrations in urine and other bodily fluids, this can determined by an abnormal liver function tests. With transaldolase deficiency there is a buildup of sedoheptulose 7-phosphate (it is increased six to sevenfold in the blood compared to normal), which decreases the change of ribose 5-phosphate into glucose 6-phosphate.

There is evidence to believe that certain defects of any components of the elastic matrix may impair and alter the structural appearance of elastic and collagen fibers. Cutis laxa and Williams syndrome have elastic matrix defects that have been directly associated with alterations in the elastin gene. Alpha-1 antitrypsin deficiency is a genetic disorder where elastin is excessively degraded by elastase, a degrading protein released by neutrophils during the inflammatory response. This leads most often to emphysema and liver disease in affected individuals.

It is thought that phosphorylase deficiency, resulting from elevated glucose levels seen in diabetes leads to an accumulation of glycogen in the skin and within the clear cells. The incidence of syringomas has been reported in up to 40 percent of people with Down syndrome and can be associated with a condition calcinosis cutis which requires prompt medical attention. Brooke-Spiegler syndrome is a rare autosomal dominant syndrome with cutaneous manifestations including syringomas and trichoepitheliomas. Nicolau-Balus syndrome is a rare autosomal dominant disorder consisting of atrophoderma vermiculata and syringomas.

Fetuses and newborns with Down syndrome without GATA1 inactivating mutations have numerous hematological abnormalities some of which are similar to those in TMD including increased numbers of circulating blasts, decreased numbers of circulating platelets and red blood cells, and increased numbers of circulating white blood cells. Also like TMD, these Down syndrome (no GATA1 mutation) individuals exhibit hepatomegaly, abnormal liver function tests, and jaundice. However, these abnormalities are usually more frequent and/or severe in TMD. Furthermore, enlarged spleen, fluid accumulations in body cavities, and leukemia cutis (i.e.

The basidia (spore-bearing cells) are four-spored, without clamps, and measure 17–32 by 6.0–7.5 μm. The hymenium lacks cystidia. The arrangement of the hyphae in the cap cuticle ranges from a cutis (with hyphae that run parallel to the cap surface) to a trichoderm (hyphae perpendicular to the cap surface); these hyphae are roughly cylindrical, and measure 3.5–8.0 μm wide, with roughly cylindrical to club-shaped ends that are 6.0–11.0 μm wide. There are no clamp connections in the hyphae of T. vaccinum.

Gerodermia osteodysplastica (GO), is a rare autosomal recessive connective tissue disorder included in the spectrum of cutis laxa syndromes. Usage of the name "Walt Disney dwarfism" is attributed to the first known case of the disorder, documented in a 1950 journal report, in which the authors described five affected members from a Swiss family as having the physical appearance of dwarves from a Walt Disney film. The terms "geroderma" or "gerodermia" can be used interchangeably with "osteodysplastica" or "osteodysplasticum", with the term "hereditaria" sometimes appearing at the end.

The Crassisporiaceae is a mushroom family of small brown, naucoroid, brown- spored agarics with thick to slightly thickened, smooth, basidiospore walls that darken to reddish brown in potassium hydroxide (KOH) solution, absence of chrysocystidia, presence of cheilocystidia, nongelatinized tissues in the lamellae, and a filamentous pileus cutis. The family is recognized based upon phylogenetic analyses using DNA sequences and depending upon the analyses varies in relationship to either the Cortinariaceae or, as described in greater detail prior to recognition as a separate family, near the Strophariaceae. Crassisporium is pyrophilous and Romagnesiella may be bryophilous.

Dry suit squeeze produces lines of redness with possible bruising where the skin was pinched between folds of the suit, while the mottled effect of cutis marmorata is usually on skin where there is subcutaneous fat, and has no linear pattern. Transient episodes of severe neurological incapacitation with rapid spontaneous recovery shortly after a dive may be attributed to hypothermia, but may be symptomatic of short term CNS involvement, which may have residual problems or relapses. These cases are thought to be under-diagnosed. Inner ear DCS can be confused with alternobaric vertigo and reverse squeeze.

He entered in February 1921, declaring his intention to major in medicine.Curtis (2011) p. 49; Deschner (1972) p. 34. Tracy was a popular student at Ripon, where he served as president of his hall and was involved in a number of college activities. He made his stage debut in June 1921, playing the male lead in The Truth.Curtis (2011) p. 53. He was very well received in the roleCurtis (2011) p. 54. and quickly developed a passion for the stage; he was reportedly "obsessive about acting to the degree that he talked about little else".Cutis (2011) p. 55.

It was initially described as Hygrophorus mavis by New Zealand mycologist Greta Stevenson in 1962 and later as Hygrocybe mavis by Egon Horak in 1971, before being placed in the genus Humidicutis by Australian Tony Young in 1997. The generic name derives from the Latin humidus "moist" and cutis "skin", referring to its moist cap. The original holotype specimen was collected on 18 June 1949 in New Zealand by T. Levin. It has been compared with collections made by E. J. H. Corner of a Mycena rimosacuta variety alba in Borneo and found to be the same species.

The cystidia present on the gill edge (cheilocystidia) are thin walled, hyaline, have a short stalk and a spherical apical portion, and measure 29–41 by 12–21 μm; cystidia are absent from the gill face. The cap cuticle ranges in cellular form from a cutis (in which the hyphae are bent over, running parallel to the cap surface) to a trichoderm (with hyphae emerging roughly parallel, like hairs, perpendicular to the cap surface); the hyphae comprising the cuticle are cylindrical, and measure 2.0–9.0 μm wide with a club-shaped tip up to 11 μm wide.

The basidia (spore-bearing cells) are four- spored, lack clamps, and measure 33–40 by 9–14 μm. Located on the gill edge, the thin-walled, inconspicuous cheilocystidia measure 20–30 by 5–9 μm and have shapes ranging from irregular cylinders to narrow clubs to flasks. The cap cuticle is arranged in the form of a cutis (with bent-over hyphae that run parallel to the cap surface) to a trichoderm (where the outermost hyphae emerge roughly parallel, perpendicular to the cap surface), comprising cylindrical to inflated hyphae that are up to 20 μm wide.

The Firmicutes (Latin: firmus, strong, and cutis, skin, referring to the cell wall) are a phylum of bacteria, most of which have gram-positive cell wall structure. A few, however, such as Megasphaera, Pectinatus, Selenomonas and Zymophilus, have a porous pseudo-outer membrane that causes them to stain gram-negative. Scientists once classified the Firmicutes to include all gram- positive bacteria, but have recently defined them to be of a core group of related forms called the low-G+C group, in contrast to the Actinobacteria. They have round cells, called cocci (singular coccus), or rod-like forms (bacillus).

Symptoms of DCS and arterial gas embolism can be virtually indistinguishable. The most reliable way to tell the difference is based on the dive profile followed, as the probability of DCS depends on duration of exposure and magnitude of pressure, whereas AGE depends entirely on the performance of the ascent. In many cases it is not possible to distinguish between the two, but as the treatment is the same in such cases it does not usually matter. Other conditions which may be confused with DCS include skin symptoms cutis marmorata due to DCS and skin barotrauma due to dry suit squeeze, for which no treatment is necessary.

Many features of gerodermia osteodysplastica (GO) and another autosomal recessive form of cutis laxa, wrinkly skin syndrome (WSS, '), are similar to such an extent that both disorders were believed to be variable phenotypes of a single disorder. Several delineating factors, however, suggest that gerodermia osteodysplastica and wrinkly skin syndrome are distinct entities, but share the same clinic spectrum. While the prevailing feature of wrinkly, loose skin is more localized with GO, it is usually systemic, yet eases in severity with age during the course of WSS. Also, as the fontanelles ("soft spots") are usually normal on the heads of infants with GO, they are often enlarged in WSS infants.

While WSS is associated with mutations of genes on chromosomes 2, 5, 7, 11 and 14; GO has been linked to mutations in the protein GORAB. A serum sialotransferrin type 2 pattern, also observed with WSS, is not present in GO patients. But perhaps the most notable feature, differentiating GO from WSS and similar cutis laxa disorders, is the age-specific metaphyseal peg sometimes found in GO-affected long bone, near the knee. Not appearing until around age 4–5, then disappearing by physeal closure, this oddity of bone is thought to represent a specific genetic marker unique to GO and its effects on bone development.

The surface of the cap is white with yellow-brown to brown-tipped raised small scales; these scales result from the breakup of the volva and the cutis. Initially, the caps are covered by a peridium—an outer covering layer of tissue. After the fruit body matures and begins to dry out, the lower part of the peridium starts to rip, usually starting from small longitudinal slits near where the peridium attaches to the top of the stem. However, the pattern of tearing is variable; in some instances, the slits may appear higher up on the peridium, in others, the peridium rips more irregularly.

Non-DS-AMKL occurs in neonates, infants, and children of all ages. Except for the lack of Down syndrome, no history of TMD, and occurrences in children that can be >4 years of age, individuals with non-DS-AMKL present with many of the symptoms, signs, and hematological findings seen in DS-AMKL. However, non-DS-AMKL is a more aggressive and rapidly progressing disorder than DS-AMKL. Nonetheless, the presentation of non-DS-AMKL is also like DS-AMKL in that it is not often accompanied by one or more extramedullary signs or symptoms of the disease such as liver enlargement, spleen enlargement, leukemia cutis, and leukostasis.

The skin on the front cover is embossed with a gallows motif and skulls and crossbones, with the Latin words Cutis Vera Johannis Horwood which translates to 'The True Skin of John Horwood'. The practice of anthropodermic bibliopegy is known to have been practised since the 17th century, and it was common to use a murderer's skin in this manner during the 18th and 19th centuries. Smith kept the skeleton at his home until his death, when it was passed to the Bristol Royal Infirmary and later to Bristol University. The skeleton was kept hanging in a cupboard at Bristol University with the noose still around its neck.

He has served as editor of the Acta Dermatovenerologica Alpina Panonica Adriatica, assistant editor of the Journal of the American Academy of Dermatology, associate editor of Cutis and Acta Dermatovenerologica Croatica, deputy editor of Mycoses, contributing editor of Dermatologic Surgery, and section editor of the Journal of Surgical Oncology. He is a member of the editorial boards of numerous journals, including American Family Physician, Anais Brasileiros de Dermatologia, International Journal of Dermatology, Indian Journal of Dermatology, Venereology and Leprology, Indian Journal of Dermatology, Giornale Italiano di Dermatologia e Venereologia, Postępy Dermatologii i Alergologii, Journal of the European Academy of Dermatology and Venereology, and Cesko-Slovenská Dermatologie.

In 2019, cefiderocol was approved in the United States as an antibacterial drug for treatment of adults 18 years of age or older with complicated urinary tract infections (cUTI), including kidney infections caused by susceptible Gram-negative microorganisms, who have limited or no alternative treatment options. The safety and effectiveness of cefiderocol was demonstrated in a study (NCT02321800) of 448 participants with cUTIs. Of the participants who were administered cefiderocol, 72.6% had resolution of symptoms and eradication of the bacteria approximately seven days after completing treatment, compared with 54.6% in participants who received an alternative antibiotic. The clinical response rates were similar between the two treatment groups.

Diagnosis is usually based on clinical observation. Various sets of criteria have been suggested to identify the disorder in an individual patient, all of which include macrocephaly and a number of the following: somatic overgrowth, cutis marmorata, midline facial birthmark, polydactyly/syndactyly, asymmetry (hemihyperplasia or hemihypertrophy), hypotonia at birth, developmental delay, connective tissue defect and frontal bossing. Currently no consensus exists about which diagnostic criteria are definitive and so evaluation by a medical geneticist or other clinician with familiarity with the syndrome is usually needed to provide diagnostic certainty. It is not clear if there are some features which are mandatory to make the diagnosis, but macrocephaly appears essentially universal though may not be congenital.

Several mutations in the FGFR2 gene (a gene coding for a protein called fibroblast growth factor receptor 2, which is involved in important signaling pathways) are known to cause Beare–Stevenson cutis gyrata syndrome; however, not all patients with the condition have a mutation in their FGFR2 gene. Any alternative underlying causes are currently unidentified. The syndrome follows an autosomal dominant pattern, meaning that if one of the two available genes carries a mutation the syndrome will result. Currently, no familial histories are known (in other words, there are no reports of cases in which a parent carrying a mutation in their FGFR2 gene then propagated said mutation to his or her child).

Very similar to B. vermiculosus in the field, but B. vermiculosus spores are larger at 11-15 X 4.5-5.5 um, and the cuticle of B. vermiculosoides lacks the long cylindrical cells (trichodermium) of B. vermiculosus. Under a microscope, the spores measure 9-12 x 3-3.5 um, appear smooth with no apical pore, the profile view appears slightly inequilateral, the face view is elongated and slightly spindle shaped. Spore bearing surfaces, Basidia contain 4 spores, measure 20-26 X 7-9 um, appear split clavate and turn glossy to transparent in KOH, with a soft yellowing in Melze's reagent. Chemical Reactivity: Ferrous sulfate (FeSO4) solution has no reaction in flesh or stipe, potassium hydroxide (KOH) solution stains cutis very dark brown, stains flesh yellow.

Other abnormalities, affecting the scalp, head, face, jaw and teeth may be found with JBS. These include: ectodermal mid-line scalp defects with sparse, oddly-patterned hair growth; aplasia cutis (underdeveloped, very thin skin) over the head, an enlarged fontanelle ("soft spot" on the head of young infants), microcephaly (undersized skull), prominent forehead, absence of eyebrows and eyelashes, mongoloidal eye shape, nasolacrimo- cutaneous fistulae (this refers to the formation of an abnormal secondary passageway from either the tear duct or lacrimal sac to the facial skin surface, possibly discharging fluid), flattened ears, micrognathism of the maxilla and mandible (underdevelopment of the upper and lower jaw, respectively), with the maxilla more prominently affected in some cases; congenital clefting of bones surrounding the optical orbit (eye socket), such as the frontal and lacrimal bone; and maldeveloped deciduous teeth ("baby teeth"), with an absence of permanent teeth.