"It's the first pandemic that urgent care has been stably around for," Zipkin said.
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"It is most desirable for currencies to move stably and reflect economic fundamentals," Kuroda said.
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If we're talking about the lowest stably-held rate for most top-tier quotes, we're back.
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But it will probably be later than that for inflation to stably move around 2 percent.
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Kuroda repeated his view that it was desirable for currency rates to move stably reflecting economic fundamentals.
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He thinks nature's penchant for asymmetry will make it easier to stably sync up diverse energy supplies.
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Who doesn't want to live stably, have three meals and stay home peacefully and just earn an income?
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Solovyov, whose bank also holds a stake in M.Video as collateral, said that debt was being "stably serviced".
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We will debate an exit strategy only after 2 percent inflation is achieved and price growth stays there stably.
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Those dots disappear and reappear as your eye jitters around "like a camera that's not being held stably," Arnold says.
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Values arise from a shared belief in a set of norms that enable a nation to function stably and peacefully.
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Yet the Vogtle expansion will be a valuable source of reliable, clean and stably priced electricity for decades to come.
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Deputy Chief Cabinet Secretary Hiroshige Seko told reporters Japan's government is worried about market moves and prefers markets to move stably.
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While the virus has caused turmoil on international markets, Taiwan's stock and foreign currency markets have performed "relatively stably", it added.
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We need people stably housed, and so we need to stop putting value judgements on what is the good exit to homelessness.
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"If the time comes, we're quite capable technically to gradually and stably adjust interest rates while ensuring markets remain stable," Amamiya said.
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They're doing this not just for PR. They want stably priced, low-cost power that fits where our electricity sector is going.
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"To achieve 2 percent inflation stably, it's very important to have a combination of monetary, fiscal steps and structural reforms," he said.
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But BOJ Governor Haruhiko Kuroda reiterated his resolve to maintain ultra-loose monetary policy until inflation is stably above its 2 percent target.
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"It's desirable for currencies to move stably reflecting economic and financial fundamentals," he said, noting this view was shared in other major economies.
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I spoke to many women for this story, and, like me, the ones I was able to interview at length were stably housed.
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Hong Kong was developing stably economically, politically and in society, and Beijing wants its people to be happy and society harmonious, Xi added.
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At the end of my month on the burn surgery service, her status, in the words of my attending, "stably unstable," I fled.
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The government is making efforts to stably manage the situation it faces as well as to bring about peace on the Korean peninsula.
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Now, Voliro's concept hexacopter is here — an acrobatic wonder drone that can stably fly in an array of arial configurations, thanks to individually tiltable axes.
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"To react to the enemy's threat and to ensure national security, the defense budget continues to grow stably," Taiwan's defense ministry said in a statement.
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Until the sociologist William Julius Wilson published "The Truly Disadvantaged," in 1987, few comprehended the terrible consequences of cleansing urban neighborhoods of the stably employed.
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Jennifer Murtazashvili, a University of Pittsburgh political scientist who studies state building and failure, said the process might unfold more quickly and stably in Afghanistan.
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National Development and Reform Commission spokeswoman Meng Wei told a news conference that China's economy has the foundations to continue to operate stably in 2020.
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Lucky Air, Capital Airlines and Tianjin Airlines said in separate statements that they maintained good relationships with their respective lessors and were operating safely and stably.
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His 20-inch-long Planophore—the first heavier-than-air machine to fly stably—was rigged with a propeller powered by a tightly twisted rubber band.
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At key moments in life when these obstacles limited my ability to live stably or move up despite hard work, altruistic strangers helped push me through.
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BOJ officials have said they will maintain the bank's massive stimulus until sustained rises in wages and strength in private consumption keep inflation stably above 2 percent.
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"Debating an exit strategy now would cause confusion," he said, stressing that the BOJ will maintain its ultra-easy policy until inflation is stably above its target.
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I will say that the only liqueurs that can be tricky are the cream-based ones, but even those are usually high enough proof to set stably.
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The Nash equilibrium not only describes optimal behaviour in settings such as markets and auctions, but also defines which traits will emerge stably from an evolutionary process.
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"Like the European Central Bank, the BOJ's policy is aimed at achieving price stability," he said, adding that it was desirable for currencies to move stably, reflecting fundamentals.
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"Debating an exit strategy now would cause confusion," he said, stressing that the BOJ will maintain its ultra-easy policy until its inflation is stably above its target.
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This would require either an entirely new technology to capture and stably store the carbon, she argued, or the expansion of largely untested technologies to an enormous scale.
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On Monday, Bank of Japan Governor Haruhiko Kuroda reiterated the central bank's resolve to maintain its massive stimulus programme until inflation is stably above its 2 percent target.
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Last Thursday morning in rural Tennessee, Esperanza's husband set off for another day of work at the nearby meatpacking plant, where he'd been stably employed the past eight years.
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Adam Gering, director of research at blockchain company Stably, said he hasn't been able to place a Prime Now order in his hometown of Redmond, Washington for two days.
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The BOJ hopes to dispel such speculation and stress it won't raise its yield targets unless the economy strengthens enough to accelerate inflation stably toward 2 percent, the sources said.
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TOKYO (Reuters) - Bank of Japan Governor Haruhiko Kuroda on Monday reiterated the central bank's resolve to maintain its massive monetary stimulus until inflation is stably above its 2 percent target.
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Due to changing temperatures, wind patterns, and dust particles in the atmosphere, astronomers sometimes have a difficult time stably collecting the light from stars and other objects in the sky.
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Taiwan would "continue to actively coordinate with the U.S. government to stably deepen the security partnership between Taiwan and the United States on a mutually beneficial basis", Taiwan's foreign ministry said.
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But a full-blown shift to monetary tightening is unlikely as BOJ Governor Haruhiko Kuroda has said inflation must exceed 2 percent stably for it to reduce its huge balance sheet.
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Motter and his team are finding rules about how to stabilize the synchronization of power grids and more stably integrate the U.S. grid with intermittent energy sources like solar and wind.
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"The reduction in homelessness among Veterans announced today shows that the strategies we are using to help the most vulnerable Veterans become stably housed are working," said VA Secretary Robert Wilkie.
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Speaking in the lower house of parliament, Kuroda said the BOJ would not continue with its aggressive monetary easing when inflation reached its price target and the economy was growing stably.
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The Earth and Moon have the right ratio such that some amount of mass could stably orbit the system at L4 and L5, the two Lagrange points actually discovered by Lagrange himself.
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Prime Minister Shinzo Abe said Japan was not conducting fiscal policy along the lines of MMT because it was aiming to stably lower the ratio of debt to gross domestic product (GDP).
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The study found that roughly half of white and Hispanic women in their early 40s were stably married, compared to less than a third of black women in the same age group.
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"The BOJ is expected to keep the current monetary stimulus to avoid sending a wrong message to the markets in the situation where prices are not rising toward its target stably," she said.
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TOKYO (Reuters) - Bank of Japan Governor Haruhiko Kuroda said there was a shared agreement among Group of Seven advanced economies that currency rates should move stably reflecting economic fundamentals, Kyodo news agency reported.
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The BOJ hopes to dispel such speculation and stress it won't raise its yield target unless the economy strengthens enough to accelerate inflation stably toward 2 percent, say sources familiar with its thinking.
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OSAKA (Reuters) - Bank of Japan Governor Haruhiko Kuroda said on Monday there was a shared view among Group of 20 major economies that currency rates should move stably reflecting economic and financial fundamentals.
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Japan has frequently issued verbal warnings against sharp yen gains, and justified them as being in line with G7 and G20 agreements that markets should move stably in a way that reflect economic fundamentals.
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And social welfare programs — though many deliver basic food, shelter, education and health care, and should persist — just can't seem to replicate what a child's stably married parents can do for him or her.
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The outline also said Japan should achieve a primary budget surplus excluding new bond sales and debt servicing costs by the fiscal year to March 2026, while stably lowering the debt-to-GDP ratio.
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Kuroda said he would explain to his G20 counterparts that the BOJ has made "quite a strong" commitment by pledging to maintain ultra-loose monetary policy until inflation stably overshoots its 2 percent inflation target.
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Asked if China supported the re-election of Hun Sen, foreign ministry spokesman Geng Shuang said in Beijing on Friday that the election was an internal affair but China wanted the country to "develop stably".
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A generation ago, working-class families were nearly as likely to be married as affluent people, but now only half the children in working-class families will be raised in adolescence by stably married parents.
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Bank of Japan Deputy Governor Hiroshi Nakaso, while declining to comment on how a strong yen could affect its policy decisions, said on Monday it was desirable for currency rates to move stably, reflecting economic fundamentals.
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While Bank of Japan Governor Haruhiko Kuroda reiterated the central bank's resolve to maintain its massive stimulus programme until 2 percent inflation is achieved stably, he also said the country's economy was expected to continue moderately expanding.
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While Bank of Japan Governor Haruhiko Kuroda reiterated the central bank's resolve to maintain its massive stimulus program until 2 percent inflation is achieved stably, he also said the country's economy was expected to continue moderately expanding.
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Things were much smoother when the BOJ exited QE in March 2006 and raised rates to 0.25 percent from zero four months later, as it had flagged its intention to withdraw stimulus when inflation had stably topped zero.
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According to a DARPA slide presentation, the goal of Insect Allies is to "stably transform multiple mature crop plants in a complex, multi-species plant and insect community with enhanced trait(s) of agricultural interest" by mid-2021.
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" Tapper's conclusion: "If the president isn't capable of leading stably and effectively he should at least for his own reputation and for the good of the country stop making things worse and consider leaving the podium to others.
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"We will continue to maintain communication with the Myanmar side and proactively and appropriately handle the problems or difficulties which arise during cooperation on the project, to allow relevant cooperation to continue to develop healthily and stably," she added.
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These early poems fail because they are staged as overwrought dramas between a "nature" too stably situated outdoors and Ammons, whose humility before creation is performed through a series of wearying guises, from pilgrim to hobo to minor prophet.
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And for 227 of those stars, TESS can search for planets in the fullest extent of their habitable zone—what humans think of as the Goldilocks zone for life, where liquid water can exist stably on a rocky planet's surface.
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This will get faster (with 5G), but 4G already satisfies my needs," said Li. "I won't really consider switching my phone until 5G has been operating stably on the market for some time without any bugs – or unless they stop offering 4G.
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This will get faster (with 5G), but 4G already satisfies my needs," said Li. "I won't really consider switching my phone until 5G has been operating stably on the market for some time without any bugs – or unless they stop offering 4G.
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BOJ Governor Haruhiko Kuroda on Monday reiterated in a speech at a quarterly meeting of the central bank's regional branch managers that the central bank is resolved to maintain its massive stimulus programme until inflation is stably above its 2 percent target.
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But BOJ Governor Haruhiko Kuroda reiterated his resolve to maintain ultra-loose monetary policy until inflation is stably above its 2 percent target, a sign the Japanese central bank will not join its U.S. and European counterparts in dialing back stimulus any time soon.
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As Jonathan Landreth writes in an accompanying essay: As China's economy slows from 30 years to roughly 10 percent annual growth, the Party is trying to hang on to power by guiding the country stably away from shrinking manufacturing and exports to growing domestic consumption.
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"If you look at the corporate earnings side, it is quite encouraging, now that some export-related companies have decided to change their euro/yen assumptions from around 115 to 125 or so," expecting the Japanese currency to trade stably against its European counterpart, said Akio Yoshino, chief economist at Amundi Japan Ltd.
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We have everything from people who are really antisocial, engage in a lot of criminal or harmful behavior—they might physically abuse children as well as sexually abuse them—and we have people who are quite prosocial—they have empathy, low in risk-taking, are stably employed, don't use alcohol or drugs.
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Commutative rings, noetherian rings and artinian rings are stably finite. A subring of a stably finite ring and a matrix ring over a stably finite ring is stably finite. A ring satisfying Klein's nilpotence condition is stably finite.
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In mathematics, particularly in abstract algebra, a ring R is said to be stably finite (or weakly finite) if, for all square matrices A, B of the same size over R, AB = 1 implies BA = 1\. This is a stronger property for a ring than its having the invariant basis number (IBN) property. Namely, any nontrivialA trivial ring is stably finite but doesn't have IBN. stably finite ring has IBN.
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In mathematics, a stably free module is a module which is close to being free.
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Although a tripod can hold a camera stably, stationary platforms are not regarded as camera stabilizers.
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Transduction is a common tool used by molecular biologists to stably introduce a foreign gene into a host cell's genome.
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The increase in temperature causes the E. coli proteins to precipitate, while the P. abyssi alkaline phosphatase remains stably in solution.
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During IDF (Intel Developer Forum) 2010, Intel demonstrated an unknown Sandy Bridge CPU running stably overclocked at 4.9 GHz on air cooling.
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Currently. is one of the few tram lines in Japan that stably make profits. There are more than 10 million users annually.
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This process repeats for each level of the outer bottom-up merge sort, at which point the array will have been stably sorted.
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Benjamin, 162 This placement must be contrasted with those on the two level, where the books held by Mary and John rest stably on their laps.
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GFP-marked endodermal epithelial cells in Hydra Cnidarians such as Hydra have become attractive model organisms to study the evolution of immunity. However, despite long-term efforts, stably transgenic animals could not be generated, severely limiting the functional analysis of genes. For analytical purposes, therefore, an important technical breakthrough in the field was the development of a transgenic procedure for generation of stably transgenic lines by embryo microinjection.
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Fortunately, his first-cousin, Raja Wodeyar I, who succeeded him, ruled stably. petty kingdoms and principalities in the region ca. 1625, during the reign of Chamaraja Wodeyar V.
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Win10Pcap implementation is also based on the NDIS 6 driver model and works stably with Windows 10. As of 2020, the project has however been inactive since 2016.
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The Unit 3 of the power plant was shut down on to undergo the EOC-19 outage after running in full cycle continuously, safely and stably for 539 days.
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Although a hybrid E/M state has been referred to as 'metastable' or transient, recent experiments in H1975 cells suggest that this state can be stably maintained by cells.
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It provides TV programs and movies on demand stably and smoothly to broadband users. Funshion uses P2P-streaming technology and supports high-volume traffic. There are 290 000 000 registered users, 60,000,000 daily users.
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Some DNA, however, cannot be stably maintained in E. coli, for example very large DNA fragments, and other organisms such as yeast may be used. Cloning vectors in yeast include yeast artificial chromosomes (YACs).
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Recently, cotton plants that stably underexpress the enzyme in seeds have been developed using RNA interference techniques, producing a plant that had been proposed as a rich source of dietary protein for developing countries.
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The lines are stably making profits and they are the only tramway operator in Japan that has not lost any of its original lines. The current fare is ¥130 for adults and ¥70 for school aged children.
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The simplest example of a stably stratified flow is an incompressible flow with density decreasing with height. In a compressible gas such as the atmosphere, the relevant measure is the vertical gradient of the entropy, which must increase with height for the flow to be stably stratified. The strength of the stratification is measured by asking how large the vertical shear of the horizontal winds has to be in order to destabilize the flow and produce the classic Kelvin–Helmholtz instability. This measure is called the Richardson number.
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This is an intensive program designed to help motivated families achieve and maintain financial self-sufficiency. In the 2015-2016 fiscal year, 93% of families remained stably housed one year after graduation, thus providing security for their children.
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Methylation of the cytosine of CpG dinucleotides is a somatically heritable and conserved regulatory mark that is generally associated with transcriptional repression. CpG islands keep their overall un-methylated state (or methylated state) extremely stably through multiple cell generations.
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Harris, Stuart A. Climatic Zonality of Periglacial Landforms in Mountain Areas. Arctic, Vol. 47, No. 2, June 1994, pp. 184-92. By contrast, the stone run boulders are fixed quite stably, providing for safer climbing and crossing of the run.
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Permanent magnet stably levitated between fingertips Earnshaw's theorem does not apply to diamagnets. These behave in the opposite manner to normal magnets owing to their relative permeability of μr < 1 (i.e. negative magnetic susceptibility). Diamagnetic levitation can be inherently stable.
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Forms of histone methylation cause repression of certain genes that are stably inherited through mitosis but that can also be erased during meiosis or with the progression of time. The induction of flowering by exposure to low winter temperatures in Arabidopsis thaliana shows this effect. Histone methylation participates in repression of expression of an inhibitor of flowering during cold. In annual, semelparous species such as Arabidopsis thaliana, this histone methylation is stably inherited through mitosis after return from cold to warm temperatures giving the plant the opportunity to flower continuously during spring and summer until it senesces.
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The GluA2 C terminus interacts with and binds to N-ethylmaleimide sensitive fusion protein, which allows for the rapid insertion of GluR2-containing AMPA receptors at the synapse. In addition, GluR2/3 subunits are more stably tethered to the synapse than GluR1 subunits.
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SERINC proteins have about 10 to 11 transmembrane domains. For SERINC5 to localize itself to the plasma membrane to inhibit infectivity by viruses, an extra c-terminal transmembrane domain is required. This extra transmembrane domain allows the protein to express itself stably.
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A permanent magnet can be stably suspended by various configurations of strong permanent magnets and strong diamagnets. When using superconducting magnets, the levitation of a permanent magnet can even be stabilized by the small diamagnetism of water in human fingers.Diamagnetically stabilized magnet levitation. (PDF) .
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Hwp1 stands for Hyphal wall protein 1. Hwp1 is a mannoprotein located on the surface of the hyphae in the hyphal form of C. albicans. Hwp1 is a mammalian transglutaminase substrate. This host enzyme allows Candida albicans to attach stably to host epithelial cells.
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Her professional interest in astronomy emerged as she pursued a Master's degree and PhD at the University of California at Berkeley. It was in her PhD thesis where she coined the term "brown dwarf" while researching small-mass objects that fail to stably fuse hydrogen.
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DBT protein causes phosphorylation and turnover of monomeric PER proteins. TIM is also phosphorylated by shaggy until sunset. After sunset, DBT disappears, so that PER molecules stably bind to TIM. PER/TIM dimer enters the nucleus several at night, and binds to CLK/CYC dimers.
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Burundi Pidgin French is a stably pidginized form of French spoken in the African nation of Burundi. It is one of several such pidgins in francophone countries. Infinitives tend to be used for all verb forms (e.g. vous savoi for vous savez 'you know').
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In 2011 the first naturally associated virus was isolated from C. elegans found outside of a laboratory. The Orsay virus is an RNA virus that is closely related to nodaviruses. The virus is not stably integrated into the host genome. It is transmitted horizontally under laboratory conditions.
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In algebra the Dixmier conjecture, asked by Jacques Dixmier in 1968, (problem 1) is the conjecture that any endomorphism of a Weyl algebra is an automorphism. Tsuchimoto in 2005, and independently Belov-Kanel and Kontsevich in 2007, showed that the Dixmier conjecture is stably equivalent to the Jacobian conjecture.
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Not all mixing is driven by density changes. Other physical forces may also mix stably-stratified layers. Sea spray and whitecaps (foaming whitewater on waves) are examples of water mixed into air, and air into water, respectively. In a fierce storm the air/water boundary may grow indistinct.
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Oxidation of guanine, particularly within CpG sites, may be especially important in learning and memory. Methylation of cytosines occurs at 60–90% of CpG sites depending on the tissue type. In the mammalian brain, ~62% of CpGs are methylated. Methylation of CpG sites tends to stably silence genes.
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This creates issues in regeneration of the tissue. Synthetic cartilage also needs to be stably attached to its underlying surface, bone. Lastly, in the case of creating synthetic cartilage to be used in joint spaces, high mechanical strength under compression needs to be an intrinsic property of the material.
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Oxidation of guanine, particularly within CpG sites, may be especially important in learning and memory. Methylation of cytosines occurs at 60–90% of CpG sites depending on the tissue type. In the mammalian brain, ~62% of CpGs are methylated. Methylation of CpG sites tends to stably silence genes.
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Crit Rev Food Sci Nutr 35(4):299-339. Food products made from cassava plants include garri (toasted cassava tubers), porridge-like fufu, the dough agbelima, and cassava flour. Research efforts have developed a transgenic cassava plant that stably downregulates linamarin production via RNA interference.Siritunga D, Sayre R (2003).
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Genetically modified mammals are mammals that have been genetically engineered. They are an important category of genetically modified organisms. The majority of research involving genetically modified mammals involves mice with attempts to produce knockout animals in other mammalian species limited by the inability to derive and stably culture embryonic stem cells.
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The courtyard air will become stably stratified, the hot air floating on top of the cold air with little mixing. The fact that the openings are at the top will trap the cool air below, though it cannot cause the temperature to drop below the nightly minimum temperature. This mechanism also works in windtowers.
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Photosynthetic eukaryotes originated following a primary endosymbiotic event, where a heterotrophic eukaryotic cell engulfed a photosynthetic cyanobacterium-like prokaryote that became stably integrated and eventually evolved into a membrane-bound organelle: the plastid. This primary endosymbiosis event gave rise to three autotrophic clades with primary plastids: the green plants, the red algae and the glaucophytes.
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A variant of GFP is naturally found in corals, specifically the Anthozoa, and several mutants have been created to span the visible spectra and fluoresce longer and more stably. Other proteins are fluorescent but require a fluorophore cofactor, and hence can only be used in vitro; these are often found in plants and algae (phytofluors, phycobiliprotein such as allophycocyanin).
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The first segment of their antennae is longer than the combined length of the other segments. They have a jerky, skipping form of flight (fluttering, rather than hovering stably like many other damselfly and dragonfly families). They perch horizontally on twigs near the water's edge. Calopterygidae nymphs have lateral gills are longer than the median gills.Calopterygidae.
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TM7x, also known as Nanosynbacter lyticus type strain TM7x HMT 952. is a phylotype of one of the most enigmatic phyla, Candidatus Saccharibacteria, formerly candidate phylum TM7. It is the only member of the candidate phylum that has been cultivated successfully from the human oral cavity, and stably maintained in vitro. and serves as a crucial paradigm.
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When exposed to ultrasound, MBs oscillate in response to the incoming pressure waves in one of two ways. With lower pressures, higher frequencies, and larger MB diameter, MBs oscillate, or cavitate, stably. This causes microstreaming near the surrounding vasculature and tissues, inducing shear stresses that can create pores on the endothelial layer. This pore formation enhances endocytosis and permeability.
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Its vision is a nation in which people live in stably integrated communities, where political and civic power is shared by people of different races and ethnicities. He led this organization until 1999. Farmer was named an honorary vice chairman of the Democratic Socialists of America. He published his autobiography Lay Bare the Heart in 1985.
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The orbit was described by Christou Apostolos and David Asher at the Armagh Observatory in Northern Ireland. The object has an absolute magnitude of 20.5. Observations by the discovering WISE telescope give a diameter of 357 meters and an albedo of 0.084. has a horseshoe orbit that allows it to stably share Earth's orbital neighborhood without colliding with it.
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First mentioned in 1332, it was stably inhabited from 1558 by lumberjacks from the province of Belluno. The colloquial language spoken in Casso is the bellunese, a Venetian dialect. Historically and culturally different from Erto, in which is spoken a Ladin dialect, Casso also belongs to the Diocese of Belluno-Feltre, different from the one of Erto.
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"The fountain pattern...can be stably performed in two ways...one can perform the fountain with different frequencies for the two hands, but that coordination is difficult because of the tendency of the limbs to synchronize."Beek, Peter J. and Lewbel, Arthur (1995). "The Science of Juggling ", Scientific American. The fountain is juggled in a circular fashion, distinguishing it from columns.
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Omohundro's book Geometric Perturbation Theory in PhysicsStephen M. Omohundro, Geometric Perturbation Theory in Physics, World Scientific Publishing Co. Pte. Ltd., Singapore (1986) 560 pages. describes natural Hamiltonian symplectic structures for a wide range of physical models that arise from perturbation theory analyses. He showed that there exist smooth partial differential equations which stably perform universal computation by simulating arbitrary cellular automata.
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Drosophila innubila is stably infected by a strain of male-killing Wolbachia bacteria. The association between Drosophila innubila and Wolbachia can vary greatly within local populations. However, their relationship is very consistent across the overall Drosophila innubila species. Male-killing by these Wolbachia results in the offspring of flies being entirely female, the biological sex with the higher reproductive output.
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My-bi HSC self-renew longer than balanced or Ly-bi HSC. The myeloid bias results from reduced responsiveness to the lymphopoetin interleukin 7 (IL-7). Subsequently, other groups confirmed and highlighted the original findings. For example, the Eaves group confirmed in 2007 that repopulation kinetics, long-term self-renewal capacity, and My-bi and Ly-bi are stably inherited intrinsic HSC properties.
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On 31 December 2000, the first crewed high- temperature superconducting maglev was tested successfully at Southwest Jiaotong University, Chengdu, China. This system is based on the principle that bulk high-temperature superconductors can be levitated stably above or below a permanent magnet. The load was over and the levitation gap over . The system uses liquid nitrogen to cool the superconductor.
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The ignition is easier and the arc burns more stably than without the addition of thorium. For powder metallurgy applications, binders have to be used for the sintering process. For the production of the tungsten heavy alloy, binder mixtures of nickel and iron or nickel and copper are widely used. The tungsten content of the alloy is normally above 90%.
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The mountain rises steeply from around to and so is a major obstacle to the predominant winds. During the wet seasons, the monsoon from the Indian ocean bring moist air to the mountain. This air is stably stratified and often cloudy. It is mostly diverted around the sides of the mountain as opposed to going over it, especially June to October.
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Exonucleolytic degradation of the poly(A) tail is often the first step in the decay of eukaryotic mRNAs. The amino acid sequence of poly(A)-specific ribonuclease shows homology to the RNase D family of 3'-exonucleases. The protein appears to be localized in both the nucleus and the cytoplasm. It is not stably associated with polysomes or ribosomal subunits.
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On June 16, 2010 Radio Free AsiaChina nuclear firm denies leak, admits tube cracks informed that there was a leak in one of the fuel tubes. Officials denied this information stating that "Daya Bay's two reactor units are functioning safely and stably. There has been no radioactive leak". Radio Free Asia quoted an unidentified expert, saying that radioactive iodine had been released.
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However, miR-122 is a promising target as it can be very selectively and effectively inhibited with antisense oligonucleotides, and as it is a conserved host factor it is hoped that the virus would not be able to acquire resistance mutations to an anti-miR-122 therapeutic. Moreover, engineering HepG2 cells to express miR-122 (HepG2-HFL cell, HepG2 cells expressing miR-122) mount an effective antiviral interferon-lambda (IFNλ) based innate immune response to hepatitis C virus (HCV) infection. HepG2 cells (stably expressing miR-122) produced a more robust IFN Response (type I and type III interferons) when challenged with other RNA viruses [ IAV-ΔNS1 and SeV ] and viral mimetics than Huh-7 and Huh-7.5 cells. HCV Induces an IFN-λ (IL28 and IL29), ISG, and Cytokine Response in these HepG2 cells with stably expressing miR-122.
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Moreover, cyanobacteria are able to float in the upper layer of the water, and are stable under varying environmental conditions, as well as throughout entire growth cycles of the mosquitos, which feed off the cyanobacteria. The most lethal combination of Bti genes was cloned in Prof. Boussiba's laboratory in the Anabaena PCC 7120 cyanobacteria. This pioneering work yielded a transgenic cyanobacteria stably expressing four different Bti genes.
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In the Edo period, the , clan, and the clans governed the area now occupied by the city. A part of the area was also governed directly by the Tokugawa Bakufu. The Oyumi clan governed their territory stably. On the other hand, according to the Sakura clan, from the beginning of the Edo period, changed governors frequently, including Takeda Nobuyoshi, Matsudaira Tadateru, , and Doi Toshikatsu.
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The C4's test drivers reported that the car handled more stably. Citroën was confident the C4 would be successful yet concerned as to whether it would beat the ,Evans (2007); p. 68. which had won the World Rally Championship for Manufacturers title in 2006 for the BP-Ford World Rally Team. The Focus, in addition had undergone its own developments during the winter break.
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The discovery that trinucleotide repeats could expand during intergenerational transmission and could cause disease was the first evidence that not all disease-causing mutations are stably transmitted from parent to offspring. There are several known categories of trinucleotide repeat disorder. Category I includes Huntington's disease (HD) and the spinocerebellar ataxias. These are caused by a CAG repeat expansion in protein-coding portions, or exons, of specific genes.
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The foam has a surface area of ∼1,663 m2/gr. Primary batteries demonstrated an open-circuit potential of 1.48 V, a specific capacity of 735 mAh/gr (Zn) (energy density of 835 Wh/kg (Zn)), a peak power density of 55 mW/cm³ and stable operation for 240 h after mechanical recharging. Two-electrode rechargeable batteries cycled stably for 180 cycles at 2 mA/cm3.
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TAFs may participate in basal transcription, serve as coactivators, function in promoter recognition or modify general transcription factors (GTFs) to facilitate complex assembly and transcription initiation. This gene encodes one of the larger subunits of TFIID that is stably associated with the TFIID complex. It contributes to interactions at and downstream of the transcription initiation site, interactions that help determine transcription complex response to activators.
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Sirna Therapeutics, Inc. was a San Francisco, California based biotechnology company that explored the use of RNA interference in human disease therapy. Sirna's development pipeline includes several small interfering RNA (siRNA) drugs, thought to stably silence the expression of specific disease-related genes. Sirna's clinical trial of an siRNA-based treatment for age-related macular degeneration is the first such trial for an siRNA drug.
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These reagents cause finely suspended particles to clump together and form larger and denser particles, called flocs, that settle more quickly and stably. This allows the separation of the solids in the clarifier to occur more efficiently and easily; aiding in the conservation of energy. Isolating the particle components first using these processes may reduce the volume of downstream water treatment processes like filtration.
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The production of this alloy was first reported by Kyoto University Professor Hiroshi Kitagawa and his research team, October 27, 2010. To make the new alloy, the Kyoto team used nanotechnology to "nebulise" the rhodium and silver and gradually mixed them with heated alcohol, with the two metals mixed stably at the atomic level. The same team also produced alternatives to other kinds of rare metals.
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The target of a gene gun is often a callus of undifferentiated plant cells or a group of immature embryos growing on gel medium in a Petri dish. After the DNA-coated gold particles have been delivered to the cells, the DNA is used as a template for transcription (transient expression) and sometimes it integrates into a plant chromosome ('stable' transformation) If the delivered DNA construct contains a selectable marker, then stably transformed cells can be selected and cultured using tissue culture methods. For example, if the delivered DNA construct contains a gene that confers resistance to an antibiotic or herbicide, then stably transformed cells may be selected by including that antibiotic or herbicide in the tissue culture media. Transformed cells can be treated with a series of plant hormones, such as auxins and gibberellins, and each may divide and differentiate into the organized, specialized, tissue cells of an entire plant.
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FISSEQ combines the spatial context of RNA-FISH and the global transcriptome profiling of RNA-seq. FISSEQ preserves the tissue allowing single molecule in situ RNA localization. The foundation of the method is a novel nucleic acid sequencing library construction method that stably cross-links cDNA amplicons within biological samples. Sequencing data is then generated through an intensive interleaved microscopy and biochemistry protocol and subsequent image processing and bioinformatics.
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In most cases, a continual low level oxidizing biocide is used, then alternating to a periodic shock dose of non-oxidizing biocides. The water consumption of the cooling tower comes from Drift, Bleed-off, Evaporation loss, The water that is immediately replenished into the cooling tower due to loss is called Make-up Water. The function of make-up water is to make machinery and equipment run safely and stably.
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Like all other Malachowski- Romanowsky-Giemsa methods, it fades with time and cannot be stably archived for long. Also its above counterparts it stains the nuclei dark purple and the nuclear feature details are not as clear as Hematoxylene and Eosin, which are thus preferred by some cytopathologists. But that way it is a complementary method (since it stains cytoplasmic details granules etc. better than H&E; stain).
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There are also ethnic and cultural rivalries at play, as well as religious motives and the political crisis with postponed elections. He says people believe the situation in the DRC is "stably bad" but in fact, it has become much, much worse. "The big wars of the Congo that were really on top of the agenda 15 years ago are back and worsening".Interview on BBC Newshour, Feb.
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Non-lytic insect cell expression is an alternative to the lytic baculovirus expression system. In non-lytic expression, vectors are transiently or stably transfected into the chromosomal DNA of insect cells for subsequent gene expression. This is followed by selection and screening of recombinant clones. The non-lytic system has been used to give higher protein yield and quicker expression of recombinant genes compared to baculovirus-infected cell expression.
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Unlike photoproteins which stably bind coelenterazine and emit light upon addition of calcium, coelenterazine is normally bound by RrLBP, the luciferin-binding protein. When stimulated, a Ca2+ ion first interacts with RrLBP, causing it to release coelenterazine. Coelenterazine is then oxidized by RLuc into coelenteramide, releasing a single photon of blue light (480 nm) in the process. This photon is captured by the adjacent GFP, releasing a photon of green light.
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Regions of the U17 RNA are complementary to rRNA and act as guides for RNA/RNA interactions, although these regions do not seem to be well conserved between organisms. There is evidence that SNORA73 (isoforms: SNORA73A and SNORA73B) functions as a regulator of chromatin function. SNORA73 is chromatin-associated RNA (caRNA) and stably linked to chromatin. Notably, SNORA73 can bind to PARP1, leading to the activation of its ADPRylation (PAR) function.
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The EJC core stably anchors the UPF complex to the mRNA, and aids in regulation of essential UPF1 protein. Ribosomes which are stalled on a PTC recruit UPF1 through interactions with the release factor eRF1 and eRF3. Along with the protein SMG1, eRF1, eRF3 and UPF1 form the complex SURF. This complex forms a bridge between the ribosome and the downstream EJC which is associated with UPF3 and UPF2.
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The key of breaking through the Mimic Defense system is the solution on how to obtain the consistent errors in most entities, achieving the escape stably, under the condition of non- cooperation and DHR environment at the same time. Trustable Computing, could be considered as a technique of encryption and belongs to the category of computational complexity technology which is not the same as Mimic defense in security principles.
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26), a ring is right Hermite if any finitely generated stably free right module over the ring is free. This is equivalent to requiring that any row vector (b1,...,bn) of elements of the ring which generate it as a right module (i.e., b1R+...+bnR=R) can be completed to a (not necessarily square) invertible matrix by adding some number of rows. (The criterion of being left Hermite can be defined similarly.) (p.
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Queen Carlota Joaquina equestrian portrait in display at the Imperial Museum of Brazil When the Portuguese royal family returned to Portugal in 1821 after an absence of 14 years, Carlota Joaquina met a country that had changed much since their departure. In 1807, Portugal had lived stably under absolutism. Napoleonic troops and political attitudes fostered by Spain's Cortes of Cádiz had brought revolutionary ideas to Portugal. In 1820, a liberal revolution commenced in Oporto.
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In some cases, the FEN1 lasts for only a short period of time and disengages from the replication complex. This causes a delay in the cleavage that the flaps displaced by Pol δ become long. When the RPA reaches a long enough length, it can bind stably. When the RPA bound flaps are refactorized to FEN1 cleavage the require another nuclease for processing, this has been identified as an alternate nuclease, DNA2.
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Importantly, pairing is the mechanism by which codons on messenger RNA molecules are recognized by anticodons on transfer RNA during protein translation. Some DNA- or RNA-binding enzymes can recognize specific base pairing patterns that identify particular regulatory regions of genes. Hydrogen bonding is the chemical mechanism that underlies the base-pairing rules described above. Appropriate geometrical correspondence of hydrogen bond donors and acceptors allows only the "right" pairs to form stably.
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The DNA encoding cameleon fusion protein must be either stably or transiently introduced into the cell of interest. Protein made by the cell according to this DNA information then serves as a fluorescent indicator of calcium concentration. In the presence of calcium, Ca2+ binds to M13, which enables calmodulin to wrap around the M13 domain. This brings the two GFP- variant proteins closer to each other, which increases FRET efficiency between them.
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Having MHC class II molecules present proper peptides that are bound stably is essential for overall immune function. Because class II MHC is loaded with extracellular proteins, it is mainly concerned with presentation of extracellular pathogens (for example, bacteria that might be infecting a wound or the blood). Class II molecules interact mainly with immune cells, like the T helper cell (CD4+). The peptide presented regulates how T cells respond to an infection.
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Once cyclin B1-Cdk1 is activated, it remains stably active for the rest of mitosis. Another mechanism by which cyclin B1-Cdk1 activity is regulated is through subcellular localization. Before mitosis almost all cyclin B1 in the cell is located in the cytoplasm, but in late prophase it relocates to the nucleus. This is regulated by the phosphorylation of cyclin B1, in contrast to phosphorylation of Cdk1 regulating the activity of the complex.
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Because the GAPDH gene is often stably and constitutively expressed at high levels in most tissues and cells, it is considered a housekeeping gene. For this reason, GAPDH is commonly used by biological researchers as a loading control for western blot and as a control for qPCR. However, researchers have reported different regulation of GAPDH under specific conditions. For example, the transcription factor MZF-1 has been shown to regulate the GAPDH gene.
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FRQ has also been shown to interact with several other proteins. It interacts at all times with FRH (FRQ-interacting RNA helicase; an essential DEAD box-containing RNA helicase in Neurospora) to form a FRQ/FRH complex (FFC). FRQ also stably interacts with casein kinase 1 (CK1) although the strength of the interaction changes with time of day. Additional interactions with other kinases including PRD-4 (CHK2) and casein kinase 2 (CKII) are known.
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From the launch of this service in July 2013, and till late 2014, Moldcell acquired in its network over 60% of the overall number of Moldovan users who decided to change their operator. Also in late 2014, Moldcell obtained the highest revenues from selling broadband internet services (35.92%). Moldcell is the single operator on the Moldovan market that continues to stably increase its turnover, from 25.41% in Q4 2012, to 30.39% in Q4 2014.
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Human skin provides a habitat for various microorganisms that stably maintain communities through commensal relationships. And skin aging is associated with changes in cutaneous physiology including interactions with a skin microbial community. This strain was first isolated from young woman. Additionally, the younger skin appeared to have high proportion of E. keratini , while the older skin had no E. keratini but rather other types of bacteria that this species has been found to be related to skin aging.
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SA1 is one of three human homologues of the yeast protein Scc3 which is a core subunit of the cohesin complex (the three human paralogues are SA1, SA2 and SA3). SA1 and SA2 are expressed in somatic cells whereas SA3 is the main SA paralogue in meiotic cells. SA1 stably binds to cohesin via the RAD21 subunit and functions as a platform for other regulatory subunits. SA1 has roles in regulating both cohesin loading and release.
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JADE1S function in apoptosis has been proposed but the mechanisms remain elusive and results are hard to reconcile. According to studies, JADE1 overexpression slows rates of cellular growth and induces cell cycle arrest protein p21. Several attempts to establish dependable cell lines stably expressing JADE1S protein have not been successful, presumably due to the negative cells self-selection. Contrary to that, another study shows that JADE1 downregulation decreased rates of DNA synthesis in synchronously dividing cells.
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A liquid-impregnated surface consists of two distinct layers. The first is a highly textured or porous substrate with features spaced sufficiently close to stably contain the second layer which is an impregnating liquid that fills in the spaces between the features. The liquid must have a surface energy well- matched to the substrate in order to form a stable film. Slippery surfaces are finding applications in commercial products, anti-fouling surfaces, anti-icing and biofilm-resistant medical devices.
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This was crucial in showing that with Esp1, Scc1 is hindered in its ability to become stably associated with chromosomes during G1, and Esp1 can in fact directly remove Scc1 from chromosomes. Dosage-response curves It has been shown by Holt et al. that separase activates Cdc14, which in turn acts on securin, thus creating a positive feedback loop that increases the sharpness of the metaphase to anaphase transition and coordination of sister- chromatid separation. Holt et al.
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AZ01 is currently undergoing Phase I clinical trials in the US. Preclinical data indicates that AZ01 has the potential to be dosed once monthly compared to the current standard of care dosed anywhere from once daily to once per week. Allozyne's technology also enables the development of next generation antibody-drug conjugates (ADCs). This approach results in homogenous ADC products that are stably conjugated. In 2014, Allozyne was acquired by MedImmune, based on its ADC technology.
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Viral vectors, especially retroviruses, stably expressing marker genes such as GFP are widely used to permanently label cells to track them and their progeny, for example in xenotransplantation experiments, when cells infected in vitro are implanted into a host animal. Gene insertion is cheaper to carry out than gene knockout. But as the silencing is sometimes non-specific and has off-target effects on other genes, it provides less reliable results. Animal host vectors also play an important role.
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Out of the three types of influenza viruses (A, B, and C), influenza A virus is a zoonotic infection with a natural reservoir almost entirely in birds. Avian influenza, for most purposes, refers to the influenza A virus. Though influenza A is adapted to birds, it can also stably adapt and sustain person- to-person transmission. Recent influenza research into the genes of the Spanish flu virus shows it to have genes adapted from both human and avian strains.
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Binocular stereo vision method requires two identical cameras with parallel optical axis to observe one same object, acquiring two images from different points of view. In terms of trigonometry relations, depth information can be calculated from disparity. Binocular stereo vision method is well developed and stably contributes to favorable 3D reconstruction, leading to a better performance when compared to other 3D construction. Unfortunately, it is computationally intensive, besides it performs rather poorly when baseline distance is large.
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The deep ocean basins are stably stratified, so mixing of surface waters with the deep ocean waters occurs only very slowly. The dissolved CO2 of the surface waters of the ocean is roughly in equilibrium with the partial pressure of CO2 in the atmosphere. As atmospheric CO2 levels are rising, the oceans are absorbing some CO2 from the atmosphere. When surface waters sink, they carry considerable amounts of CO2 into the deep oceans, away from the atmosphere.
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The net force in this case is along the axial direction of the trap, which cancels out the scattering force of the laser light. The cancellation of this axial gradient force with the scattering force is what causes the bead to be stably trapped slightly downstream of the beam waist. The standard tweezers works with the trapping laser propagated in the direction of gravityLynn Paterson "Novel micromanipulation techniques in optical tweezers", (2003) and the inverted tweezers works against gravity.
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Warfarin and other 4-hydroxycoumarins block the action of VKOR. This results in decreased concentrations of vitamin K and vitamin K hydroquinone in tissues, such that the carboxylation reaction catalyzed by the glutamyl carboxylase is inefficient. This results in the production of clotting factors with inadequate Gla. Without Gla on the amino termini of these factors, they no longer bind stably to the blood vessel endothelium and cannot activate clotting to allow formation of a clot during tissue injury.
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The most efficient ligation temperature for blunt-ended DNA would therefore be the temperature at which the greatest number of alignments can occur. The majority of blunt-ended ligations are carried out at 14-25 °C overnight. The absence of stably annealed ends also means that the ligation efficiency is lowered, requiring a higher ligase concentration to be used. A novel use of DNA ligase can be seen in the field of nano chemistry, specifically in DNA origami.
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A wax emulsion is a stable mixture of one or more waxes in water. Waxes and water are normally immiscible but can be brought together stably by the use of surfactants and a clever preparation process. Strictly speaking a wax emulsion should be called a wax dispersion since the wax is solid at room temperature. However, because the preparation takes place above the melting point of the wax, the actual process is called emulsification, hence the name wax emulsion.
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TALEN has been used to efficiently modify plant genomes, creating economically important food crops with favorable nutritional qualities. They have also been harnessed to develop tools for the production of biofuels. In addition, it has been used to engineer stably modified human embryonic stem cell and induced pluripotent stem cell (IPSCs) clones and human erythroid cell lines, to generate knockout C. elegans, knockout rats, knockout mice, and knockout zebrafish. Moreover, the method can be used to generate knockin organisms.
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Once differentiated tissues are formed, CpG island methylation is generally stably inherited from one cell division to the next through the DNA methylation maintenance machinery. In cancer, a number of mutational changes are found in protein coding genes. Colorectal cancers typically have 3 to 6 driver mutations and 33 to 66 hitchhiker or passenger mutations that silence protein expression in the genes affected. However, transcriptional silencing may be more important than mutation in causing gene silencing in progression to cancer.
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The sound source has now broken through the sound speed barrier, and is traveling at 1.4 times the speed of sound, c (Mach 1.4). Because the source is moving faster than the sound waves it creates, it actually leads the advancing wavefront. The sound source will pass by a stationary observer before the observer actually hears the sound it creates. However, in practical applications, a supersonic aircraft must operate stably in both subsonic and supersonic profiles, hence aerodynamic design is more complex.
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Biolistics has proven to be a versatile method of genetic modification and it is generally preferred to engineer transformation-resistant crops, such as cereals. Notably, Bt maize is a product of biolistics. Plastid transformation has also seen great success with particle bombardment when compared to other current techniques, such as Agrobacterium mediated transformation, which have difficulty targeting the vector to and stably expressing in the chloroplast. In addition, there are no reports of a chloroplast silencing a transgene inserted with a gene gun.
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Positive α-Synuclein staining of a Lewy body from a patient who had Parkinson's disease. Classically considered an unstructured soluble protein, unmutated α-synuclein forms a stably folded tetramer that resists aggregation. This observation, though reproduced and extended by several labs, is still a matter of debate in the field due to conflicting reports. Nevertheless, alpha-synuclein aggregates to form insoluble fibrils in pathological conditions characterized by Lewy bodies, such as Parkinson's disease, dementia with Lewy bodies and multiple system atrophy.
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All described phasevarions regulate expression of proteins that are involved in host colonization, survival, and pathogenesis, and many regulate putative vaccine targets. The presence of phasevarions complicates identification of stably expressed proteins, as the regulated genes do not contain any identifiable features. The only way to identify genes in a phasevarion is by detailed study of the organisms containing such systems. Study of the phasevarions, and identification of proteins they regulate, is therefore critical to generate effective and stable vaccines.
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The selectivity factor can be used for the creation of stably transfected cell lines, an important tool in drug discovery, biomedical research, and biological pathway investigation. Cell line creation involves transfection (transferring the gene into the cell line), and selection (applying selective pressure in the form of an antibiotic. Transfection efficiency is dependent on cell type, cell density, vector, and transfection method. Selection efficiency depends on the capacity of the antibiotic to kill the parental cells but not the transfected cells.
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The fresh ice (dark) can be seen spanning the equator in this image comparing infrared and green wavelengths. Fresh blue ice at Rhea's equator suggest impacts from deorbiting ring material. Simulations suggest that solid bodies can stably orbit Rhea near its equatorial plane over astronomical timescales. They may not be stable around Dione and Tethys because those moons are so much closer to Saturn, and therefore have much smaller Hill spheres, or around Titan because of drag from its dense atmosphere.
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With a focus on video synthesis and processing, vvvv uses the toolkit DirectX and, as such, is available for Microsoft Windows systems only, although it is known to run stably under Parallels and VMware Fusion. vvvv currently supports DirectX 9 (including PS 3 and VS 3 shader techniques) and DirectX 11. vvvv was initially developed by the Frankfurt- based media collective MESO as an in-house tool for their own projects, but was then released. vvvv is now maintained by the VVVV group.
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Conjugation involves physical contact between donor and recipient cells and is able to mediate transfers of genes between domains, such as between bacteria and yeast. DNA is transmitted from donor to recipient either by self-transmissible or mobilizable plasmid. Conjugation may mediate the transfer of chromosomal sequences by plasmids that integrate into the chromosome. Despite the multitude of mechanisms mediating gene transfer among bacteria, the process's success is not guaranteed unless the received sequence is stably maintained in the recipient.
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These are attracted to field maxima, which do not exist in free space. Diamagnets (which induce a negative moment) are attracted to field minima, and there can be a field minimum in free space. A thin slice of pyrolytic graphite, which is an unusually strong diamagnetic material, can be stably floated in a magnetic field, such as that from rare earth permanent magnets. This can be done with all components at room temperature, making a visually effective demonstration of diamagnetism.
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The planet HD 45350 b is named Peitruss. The name was selected in the NameExoWorlds campaign by Luxembourg, during the 100th anniversary of the IAU. Peitruss is derived from the name of the Luxembourg river Pétrusse. Dynamical simulations covering a period of 107 years show that a second, low-mass, planet could only orbit stably if it were no more than 0.2 AU away from the star; in the simulations, these planets show oscillations in eccentricity up to an eccentricity of 0.25.
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International A-class catamaran rules initially allowed hydrofoils but were changed to specifically limit the foil span in 2000 after the measurer and president were approached by Jeremy Banks, an Australian sailor, with a hydrofoiling design. Over time sailors still found a way to foil. The 2014 A-Class Catamaran World Titles in Takapuna New Zealand demonstrated early foiling capabilities to the class. Now the A-Class can foil stably downwind in 6 knots and upwind in 12 knots or more.
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"Magni-phi" variant of the classical experimental arrangement with more than two elements. Wertheimer's classic experiments used two light lines or curves repeatedly presented one after the other using a tachistoscope. If certain, relatively short, intervals between stimuli were used, and the distance between the stimuli was suitable, then his subjects (who happened to be his colleagues Wolfgang Köhler and Kurt Koffka) reported seeing pure "objectless" motion. However, it turns out to be difficult to demonstrate phi stably and convincingly.
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Earnshaw's theorem proves that using only paramagnetic materials (such as ferromagnetic iron) it is impossible for a static system to stably levitate against gravity.Ignorance = Maglev = Bliss For 150 years scientists believed that stable magnetic levitation was impossible. Then Roy Harrigan came along. By Theodore Gray Posted February 2, 2004 For example, the simplest example of lift with two simple dipole magnets repelling is highly unstable, since the top magnet can slide sideways, or flip over, and it turns out that no configuration of magnets can produce stability.
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Its wing was set high on the fuselage, with swept fins at the tips inclined at about 60°, carrying short ailerons. The tips also carried long, wide planing floats which projected a long way forward of the leading edge to support the fuselage stably above the surface when on water. Forward of the wings the fuselage was flat sided and quite shallow, so the pilot was semi-recumbent under a long canopy. Aft, a long dorsal fin extends to a T tail with rudder and horizontal stabiliser.
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528) earlier called a commutative ring with this property an H-ring. According to (§0.4), a ring is Hermite if, in addition to every stably free (left) module being free, it has IBN. All commutative rings which are Hermite in the sense of Kaplansky are also Hermite in the sense of Lam, but the converse is not necessarily true. All Bézout domains are Hermite in the sense of Kaplansky, and a commutative ring which is Hermite in the sense of Kaplansky is also a Bézout ring (, pp.
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The transport of methane emitted from the seeps on Heceta Bank is driven by the flow of the California Undercurrent. The current distributes the gas in the hydrate stability zone, where methane hydrates can form stably in the sediment. The clearing time of methane emitted into the water column on the bank is estimated to be around 22 hours based on average current speeds at a depth of 100–480 m. Microbial methane oxidation only accounts for roughly 14% of the overall methane transport in the area.
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Tripartite motif-containing protein 16 is a protein that in humans is encoded by the TRIM16 gene. This gene was identified as an estrogen and anti-estrogen regulated gene in epithelial cells stably expressing estrogen receptor. The protein encoded by this gene contains two B box domains and a coiled-coiled region that are characteristic of the B box zinc finger protein family. The proteins of this family have been reported to be involved in a variety of biological processes including cell growth, differentiation and pathogenesis.
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Wild-type AAV has attracted considerable interest from gene therapy researchers due to a number of features. Chief amongst these is the virus's apparent lack of pathogenicity. It can also infect non-dividing cells and has the ability to stably integrate into the host cell genome at a specific site (designated AAVS1) in the human chromosome 19. This feature makes it somewhat more predictable than retroviruses, which present the threat of a random insertion and of mutagenesis, which is sometimes followed by development of a cancer.
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Ribosomes, which synthesize the proteome of cells, are complex ribonucleoproteins that, in eukaryotes, contain 79–80 proteins and four ribosomal RNAs(rRNAs). General or specialized chaperones solubilize the ribosomal proteins and facilitate their import into the nucleus. Assembly of the eukaryotic ribosome appears to be driven by the ribosomal proteins in vivo when assembly is also aided by chaperones. Most ribosomal proteins assemble with rRNA co-transcriptionally, becoming associated more stably as assembly proceeds, and the active sites of both subunits are constructed last.
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Hepadnaviruses, as their "hepa" name implies, infect liver cells and cause hepatitis. This is true not only of the human pathogen Hepatitis B Virus but also the hepadnaviruses that infect other organisms. The "adhesion" step of the dynamic phase—in which an exterior viral protein stably interacts with a host cell protein—determines cell tropism. In the case of HBV the host receptor is human sodium taurocholate receptor (NTCP), a mediator of bile acid uptake, and the virus anti-receptor is the abundant HB-AgS envelope protein.
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Cyanophage replication has two dominant cycles: the lytic cycle and the lysogenic cycle. Viral nucleic-acid replication and immediate synthesis of virus-encoded protein is considered to be the lytic cycle. Phages are considered lytic if they only have the capacity to enter the lytic cycle; whereas, temperate phage can either enter the lytic cycle or become stably integrated with the host genome and enter the lysogenic cycle. To meet the metabolic demand of replication, viruses recruit a multitude of strategies to sequester nutrients from their host.
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From 1947, work began on a new axial-flow turbojet by OKB-165, led by Arkhip Mikhailovich Lyulka. OKB Mikoyan-Guryevich designed the I-350 around this engine, the Lyul'ka TR-3A (redesignated as the Lyulka AL-5). Resembling a scaled-up MiG-17, the I-350 had a long slim fuselage, mid-set 57° swept wings and a wide-chord fin mounting a tailplane at half-span. Given the OKB designation Izdeliye M, it was the first Soviet fighter able to fly stably at supersonic speeds.
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Genetic transfer can occur across wide taxonomic levels in microorganisms and become stably integrated into the new microbial populations, as has been observed through protein sequencing. Reticulation in bacteria usually only involves the transfer of only a few genes or parts of these. Reticulate evolution driven by lateral gene transfer has also been observed in marine life. Lateral genetic transfer of photo-response genes between planktonic bacteria and Archaea has been evidenced in some groups, showing an associated increase in environmental adaptability in organisms inhabiting photic zones.
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A liquid-impregnated surface consists of two distinct layers. The first is a highly textured or porous substrate with features spaced sufficiently close to stably contain the second layer which is an impregnating liquid that fills in the spaces between the features. The liquid must have a surface energy well-matched to the substrate in order to form a stable film. These surfaces bioimitate the carnivorous Venezuelan Pitcher Plant, which uses microscale hairs to create a water slide that causes ants to slip to their death.
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ALPHA, a successor of the ATHENA collaboration, was formed to stably trap antihydrogen. While electrically neutral, its spin magnetic moments interact with an inhomogeneous magnetic field; some atoms will be attracted to a magnetic minimum, created by a combination of mirror and multipole fields. In November 2010, the ALPHA collaboration announced that they had trapped 38 antihydrogen atoms for a sixth of a second, the first confinement of neutral antimatter. In June 2011, they trapped 309 antihydrogen atoms, up to 3 simultaneously, for up to 1,000 seconds.
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Heterogeneous nuclear RNAs (hnRNAs) which include mRNA precursors and mature mRNAs are associated with specific proteins to form heterogeneous ribonucleoprotein (hnRNP) complexes. Heterogeneous nuclear ribonucleoprotein L is among the proteins that are stably associated with hnRNP complexes and along with other hnRNP proteins is likely to play a major role in the formation, packaging, processing, and function of mRNA. Heterogeneous nuclear ribonucleoprotein L is present in the nucleoplasm as part of the HNRP complex. HNRP proteins have also been identified outside of the nucleoplasm.
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Fig. 4 The strongest possible size effect occurs for specimens with similar deep notches (Fig. 4b), or for structures in which a large crack, similar for different sizes, forms stably before the maximum load is reached. Because the location of fracture initiation is predetermined to occur at the crack tip and thus cannot sample the random strengths of different RVEs, the statistical contribution to the mean size effect is negligible. Such behavior is typical of reinforced concrete, damaged fiber-reinforced polymers and some compressed unreinforced structures.
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Sample of a titanium-zirconium-nickel alloy inside the Electrostatic Levitator vacuum chamber at NASA's Marshall Space Flight Center. Electrostatic levitation is the process of using an electric field to levitate a charged object and counteract the effects of gravity. It was used, for instance, in Robert Millikan's oil drop experiment and is used to suspend the gyroscopes in Gravity Probe B during launch. Due to Earnshaw's theorem, no static arrangement of classical electrostatic fields can be used to stably levitate a point charge.
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Plants that have lost function of LHY and CCA1 lose the ability to stably maintain circadian rhythm and other output phenomena. In one study, such plants showed photoperiod- insensitive early flowering under long- day (16 hours of light/ 8 hours of dark) conditions and short day (8 hours of light, 16 hours of dark conditions), and arrhythmicity under constant light conditions.Aihara, Kohei, and Satoshi Naramoto. "Increase in vascular pattern complexity caused by mutations in LHY and CCA1 in Arabidopsis thaliana under continuous light" Plant Biotechnology Vol. 31.
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When a domain contains too many molecules, it becomes unstable and divides into two domains aligned in opposite directions, so that they stick together more stably, as shown at the right. When exposed to a magnetic field, the domain boundaries move, so that the domains aligned with the magnetic field grow and dominate the structure (dotted yellow area), as shown at the left. When the magnetizing field is removed, the domains may not return to an unmagnetized state. This results in the ferromagnetic material's being magnetized, forming a permanent magnet.
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Hairpin II appears to be a dynamic feature of FourU's secondary structure. It undergoes a conformational shift when exposed to temperatures above 45 °C, becoming increasingly unpaired as temperature rises. Hairpin I, in contrast, remains stably base-paired in temperatures as high as 50 °C, which implies the structural shift of hairpin II from closed to open may have an important role in heat shock response. A later study used mutant analysis and calculations of enthalpy and entropy to support a cooperative zipper-type unfolding mechanism of FourU hairpin II in response to temperature increase.
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In contrast, Mg-rich olivine does not occur stably with silica minerals, as it would react with them to form orthopyroxene ((Mg,Fe)2Si2O6). Mg-rich olivine is stable to pressures equivalent to a depth of about within Earth. Because it is thought to be the most abundant mineral in Earth's mantle at shallower depths, the properties of olivine have a dominant influence upon the rheology of that part of Earth and hence upon the solid flow that drives plate tectonics. Experiments have documented that olivine at high pressures (e.g.
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The rotors were made of carbon fibre and were attached to a retrofitted trimaran and propelled the vessel stably through the water at a speed of six knots. In 2009, Wärtsilä proposed a cruiseferry that would utilise Flettner rotors as a means of reducing fuel consumption. The Finnish ferry operator Viking Line adopted the idea, with MS Viking Grace built in 2011–2012, initially without rotors. A rotor system was retrofitted in 2018. In 2014 and 2015, Norsepower installed twin rotor sails on Finnish shipping company Bore's RoRo vessel M/V Estraden.
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The slope of the inner trench slope of an accretionary convergent margin reflects continuous adjustments to the thickness and width of the accretionary prism. The prism maintains a ‘critical taper’, established in conformance with Mohr–Coulomb theory, with slope determined by the material properties of the sediments. A package of sediments scraped off the downgoing lithospheric plate deforms until it and the accretionary prism that it has been added to attain the maximum slope supported by the sediments. Once this critical taper is attained, the wedge slides stably along its basal décollement.
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The cotton pygmy goose was first described and given a binomial name by Gmelin in 1789 who called it Anas coromandeliana. The French naturalist Buffon had called it Sarcelle de Coromandel. It was then placed under Cheniscus before being relatively stably placed in the genus Nettapus within the tribe Cairinini that includes other perching ducks. It is one of three species in the genus, noted for sexual dimorphism, and is the only species in which there is a marked difference in the non-breeding plumage of the males.
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It had four combustion chambers, reached a height of 200 feet, and corrected its vertical path using blast vanes until one chamber burned through. This flight demonstrated that a rocket with multiple combustion chambers could fly stably and be easily guided. In July 1937 he replaced the guidance vanes with a movable tail section containing a single combustion chamber, as if on gimbals (thrust vectoring). The flight was of low altitude, but a large disturbance, probably caused by a change in the wind velocity, was corrected back to vertical.
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SCHEMA is a computational algorithm used in protein engineering to identify fragments of proteins (called schemas) that can be recombined without disturbing the integrity of the proteins' three-dimensional structure. The algorithm calculates the interactions between a protein's different amino acid residues to determine which interactions may be disrupted by swapping structural domains of the protein. By minimizing these disruptions, SCHEMA can be used to engineer chimeric proteins that stably fold and may have altered function relative to their parent proteins. SCHEMA algorithm has been applied in the recombinant libraries of distantly related β-lactamases.
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Rickettsia prowazekii is a species of gram-negative, alphaproteobacteria, obligate intracellular parasitic, aerobic bacillus bacteria that is the etiologic agent of epidemic typhus, transmitted in the feces of lice. In North America, the main reservoir for R. prowazekii is the flying squirrel. R. prowazekii is often surrounded by a protein microcapsular layer and slime layer; the natural life cycle of the bacterium generally involves a vertebrate and an invertebrate host, usually an arthropod, typically the human body louse. A form of R. prowazekii that exists in the feces of arthropods remains stably infective for months.
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Overall, Vietnam remained very efficiently and stably governed except in times of war and dynastic breakdown, and its administrative system was probably far more advanced than that of any other Southeast Asian states and was more highly centralized and stable governed among Asian states. No serious challenge to the king's authority ever arose, as titles of nobility were bestowed purely as honors and were not hereditary. Periodic land reforms broke up large estates and ensured that powerful landowners could not emerge. No religious/priestly class ever arose outside of the mandarins either.
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Zaikoski's Arr-Kelaan grew into a full-scale Dungeons & Dragons campaign setting, compatible with 2nd edition rules and available online. In contrast to many RPG-derived works, Rowles' Arr-Kelaan is scantly recognizable. The geography and the basic D&D; elements of a vaguely medieval society and polytheistic/henotheistic pantheons are the same, but whereas the game focuses on adventurers in a world stably ruled by Travellers-turned-gods for millennia, Gods portrays the effects of the Travellers on the world and each other when they first arrive and establish themselves.
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The phone contains expected smartphone applications, and Wisepilot Navigation Software, Google Maps, YouTube, Sony's PlayNow Arena and TrackID (to identify a song by recording a small part of it). Sony Ericsson was widely criticized by X8 users for failing to provide Android firmware upgrades to 2.2 Froyo or 2.3 Gingerbread. They later stated that the phone's hardware was unable to run anything beyond 2.1 Eclair. They were later proved wrong by the Android modding community, who released their own versions of Android 2.2 and 2.3 in subsequent months, which ran stably on the X8.
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Its works exist on the tension between modernisation and tradition; local and global. TheatreWorks’ projects present the hybrid identity of the contemporary Asian and embrace the multiple realities. TheatreWorks is a multi-faceted arts company but always working intensively across languages, art forms, disciplines and socio-political borders. Rather than residing stably in the staid singularity of one Art or one Culture, TheatreWorks believes in the idea of leaving one’s own position, one’s locality, and locating oneself in the unknown – to co-work and co-create in a third space.
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While Siglec-8 ligation does not cause mast cell apoptosis, it inhibits FcεRIα-mediated Ca2+ flux and release of prostaglandin D2 and histamine. However, the release of IL-8 is not prevented by Siglec-8 ligation in mast cells. In experiments using the rat basophilic leukemia cell line RBL-2H3 stably transfected with Siglec-8, the inhibitory effect of Siglec-8 ligation on FcεRIα-mediated degranulation and Ca2+ flux was found to be dependent on the intact ITIM. There are no published data regarding the function of Siglec-8 on basophils.
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Lighter water masses float over denser ones (just as a piece of wood or ice will float on water, see buoyancy). This is known as "stable stratification" as opposed to unstable stratification (see Brunt-Väisälä frequency) where denser waters are located over less dense waters (see convection or deep convection needed for water mass formation). When dense water masses are first formed, they are not stably stratified, so they seek to locate themselves in the correct vertical position according to their density. This motion is called convection, it orders the stratification by gravitation.
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Osteocytes are the most abundant cells in bone and are also the most sensitive to such fluid flow caused by mechanical loading. Upon sensing a load, osteocytes regulate bone remodeling by signaling to other cells with signaling molecules or direct contact. Additionally, osteoprogenitor cells, which may differentiate into osteoblasts or osteoclasts, are also mechanosensors and may differentiate one way or another depending on the loading condition. Computational models suggest that mechanical feedback loops can stably regulate bone remodeling by reorienting trabeculae in the direction of the mechanical loads.
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A large number of cloning vectors are available, and choosing the vector may depend a number of factors, such as the size of the insert, copy number and cloning method. Large insert may not be stably maintained in a general cloning vector, especially for those with a high copy number, therefore cloning large fragments may require more specialized cloning vector. The pUC plasmid has a high copy number, contains a multiple cloning site (polylinker), a gene for ampicillin antibiotic selection, and can be used for blue-white screen.
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In silico study provided an added support in showing that hetero- oligomerization was energetically favorable. The hetero-oligomeric populations of PKM2 showed altered activity and affinity, and their expression resulted in an increased growth rate of Escherichia coli as well as mammalian cells, along with an increased rate of polyploidy. These features are known to be essential to tumor progression. Further, cells stably expressing exogenous wild- or mutant-PKM2 (K422R or H391Y) or co-expressing both wild and mutant (PKM2-K422R or PKM2-H391Y), were assessed for cancer metabolism and tumorigenic potential.
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This results in global repression and allows housekeeping genes to be expressed in all cells. In the post-implantation stage, methylation patterns are stage- and tissue-specific, with changes that would define each individual cell type lasting stably over a long period. Whereas DNA methylation is not necessary per se for transcriptional silencing, it is thought nonetheless to represent a “locked” state that definitely inactivates transcription. In particular, DNA methylation appears critical for the maintenance of mono-allelic silencing in the context of genomic imprinting and X chromosome inactivation.
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The gene silencing effects of transfected designed siRNA are generally transient, but this difficulty can be overcome through an RNAi approach. Delivering this siRNA from DNA templates can be done through several recombinant viral vectors based on retrovirus, adeno-associated virus, adenovirus, and lentivirus. The latter is the most efficient virus that stably delivers siRNA to target cells as it can transduce nondividing cells as well as directly target the nucleus. These specific viral vectors have been synthesized to effectively facilitate siRNA that is not viable for transfection into cells.
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For example, the OS/2 core system supports 32-bit programs, and can be run without the GUI. The DPMI solution appears to be mainly needed to address third party need to get DOS protected mode programs running stably on Windows 3.x before the dominant operating system vendor, Microsoft, could or would address the future of 32-bit Windows. In addition, Microsoft didn't see the answer to the 32-bit transition as a 32-bit DOS, but rather a 32-bit Windows with a completely different (and incompatible) API.
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Surviving cells will have the exogenous DHFR gene along with the gene of interest integrated in its genome. The growth rate and the level of recombinant protein production of each cell line varies widely. To obtain a few stably transfected cell lines with the desired phenotypic characteristics, evaluating several hundred candidate cell lines may be necessary. The CHO and CHO-K1 cell lines can be obtained from a number of biological resource centres such as the European Collection of Cell Cultures, which is part of the Health Protection Agency Culture Collections.
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On the other hand, GO-VC can be dispersed in water-soluble polymer gel transparently and uniformly or can be stably dissolved for a long time. The Fat-soluble vitamin C derivatives such as ascorbyl tetrahexyl decanoate (VC- IP) are almost insoluble in water, making it difficult to mix in water-soluble formulations such as lotions without the use of surfactants. Fat-soluble vitamin C derivatives causes lipid oxidation problems when lipids are released, and the color of the formulation tends to change. GO-VC can solve these problems almost completely.
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After Naum tied for first with Rybka in the 2008 Internet Computer Chess Tournament,CCT 10 it did not compete in any other over-the-board (OTB) tournaments. In early 2009, Naum attained second place behind Rybka on chess engine rating lists, such as CCRL In 2012, the development of Naum was discontinued, and it has since only had minor updates. In 2013, Naum participated in the Thoresen Chess Engines Competition and the author released a software patch to enable the engine to run stably with 16 processors. Finally the author released it as freeware.
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Ligands do not bind to NGFIB, so modulation occurs at the level of protein expression and posttranslational modification. Besides these, NR4A1 can mediate T cell function, the transcription factor NR4A1 is stably expressed at high levels in tolerant T cells. Overexpression of NR4A1 inhibits effector T cell differentiation, whereas deletion of NR4A1 overcomes T cell tolerance and exaggerates effector function, as well as enhancing immunity against tumor and chronic virus. Mechanistically, NR4A1 is preferentially recruited to binding sites of the transcription factor AP-1, where it represses effector gene expression by inhibiting AP-1 function.
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Within the first fraction of a second of the universe's existence, the four fundamental forces had separated. As the universe continued to cool down from its inconceivably hot state, various types of subatomic particles were able to form in short periods of time known as the quark epoch, the hadron epoch, and the lepton epoch. Together, these epochs encompassed less than 10 seconds of time following the Big Bang. These elementary particles associated stably into ever larger combinations, including stable protons and neutrons, which then formed more complex atomic nuclei through nuclear fusion.
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Since EosFP can be used in fusion constructs while maintaining functionality of the protein of interest, it is a popular choice for multi-colour labelling studies. In a dual-colour labelling experiment to map the stages of mitosis, HEK293 cells were first stably transfected with tubulin-binding protein cDNA fused to EGFP for visualization of the spindle apparatus. Then, transient transfection of recombination signal-binding protein (RBP) fused to d2EosFP was used to visualize the beginning of mitosis. Photoconversion was completed by fluorescent microscopy and highlighted the separation between two sets of chromosomes during anaphase, telophase and cytokinesis.
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Massimiliano Versace's pioneered research in continual learning neural networks, in particular applied to cortical models of learning and memory, and how to build intelligent machines equipped with low-power, high density neural chips that implement large-scale brain circuits of increasing complexity. His Synchronous Matching Adaptive Resonance Theory (SMART) model shows spiking laminar cortical circuits self-organize and stably learn relevant information, and how these circuits be embedded in low-power, memristor based hybrid CMOS chip and used to solve challenging pattern recognition problems. His work has been featured on Fortune, Inc, Tech Crunch, IEEE Spectrum, Venture Beat, among others.
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Early studies of the bioluminescence of Aequorea by E. Newton Harvey had noted that the bioluminescence appears as a ring around the bell, and occurs even in the absence of air. This was remarkable because most bioluminescence reactions appeared to require oxygen, and led to the idea that the animals somehow store oxygen. It was later discovered that the apoprotein can stably bind coelenterazine and oxygen is required for the regeneration to the active form of aequorin. However, in the presence of calcium ions, the protein undergoes a conformational change and through oxidation converts its prosthetic group, coelenterazine, into excited coelenteramide and CO2.
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Horizontal rolls are counter-rotating vortex rolls that are nearly aligned with the mean wind of the Planetary Boundary Layer (PBL). They can be caused by convection in the presence of a moderate wind and/or dynamic inflection point instabilities in the mean wind profile. Early theory on the features predict that the vortices may be aligned up to 30° to the left for stably stratified environments, 18° to the left for neutral environments, and nearly parallel to the mean wind for unstably stratified (convective) environments. This theory has been supported by aircraft observations from several field experiments.
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He and his co- workers described high-throughput high-content screening (HCS) campaign to identify small-molecule inhibitors of AR nuclear localization in the C4-2 CRPC cell line stably transfected with GFP-AR. The implementation of this HCS assay to screen a library of 219,055 compounds led to the discovery of 3 small molecules capable of inhibiting AR nuclear localization and function in C4-2 cells, demonstrating the feasibility of using this cell-based phenotypic assay to identify small molecules targeting the subcellular localization of AR . In 2018, he published four pivotal scientific works, which would revolutionise modern biotechnology and cancer research.
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These homologs are present in purified phage particles of other phages, as well as bacterial genomes. The presence of c4 antisense RNAs in bacteria is to be expected, since the P1 and P7 phages are temperate and can stably integrate into the host genome. The c4 antisense RNA consists of a three-stem junction. The terminus of the stem designated as "P2" very often conforms to highly stable tetraloop motifs that were previously elucidated, conforming to the consensus GNRA, UNCG or CUNG, where R represents either A or G nucleotides, and N can be any nucleotide.
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These two cell populations are kept separate by a mechanism of cell segregation linked to the heritable expression of a selector gene. A selector gene is one that is expressed in one group of cells but not the other, giving the founder cells and their descendants different instructions. Eventually these selector genes become fixed in either an expressed or unexpressed state and are stably inherited to the descendants, specifying the identity of the compartment and preventing these genetically different cell populations from intermixing. Therefore, these selector genes are key for the formation and maintenance of lineage compartments.
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Leptotene is followed by the zygotene stage, also known as zygonema, from Greek words meaning "paired threads", which in some organisms is also called the bouquet stage because of the way the telomeres cluster at one end of the nucleus. In this stage the homologous chromosomes become much more closely (~100 nm) and stably paired (a process called synapsis) mediated by the installation of the transverse and central elements of the synaptonemal complex. Synapsis is thought to occur in a zipper-like fashion starting from a recombination nodule. The paired chromosomes are called bivalent or tetrad chromosomes.
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As no single gene is responsible for the development of structures within multicellular organisms, these patterns arise from the complex interactions between many cells. Within eukaryotes, there exist structural features of chromatin that influence the transcription of genes, often in the form of modifications to DNA and chromatin that are stably inherited by daughter cells. These features are called "epigenetic" because they exist "on top" of the DNA sequence and retain inheritance from one cell generation to the next. Because of epigenetic features, different cell types grown within the same medium can retain very different properties.
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Next, tape recorders changed from open-reel to cassette tape, and in 1972 the radio cassette deck, or "boombox", was released; it became a popular for personal use mainly among young people. As far as Mabuchi Motor was concerned, the key part of a radio cassette deck was that it must be able to spin quietly and stably to produce quality sound. The rotation speed could not change even with changes in voltage, temperature or load. A regular DC motor would not suffice; instead, the company had to develop a new motor with the capability to adjust its speed, a "governor motor".
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A section of TM is a vector field on M, and the dual bundle to TM is the cotangent bundle, which is the disjoint union of the cotangent spaces of M . By definition, a manifold M is parallelizable if and only if the tangent bundle is trivial. By definition, a manifold M is framed if and only if the tangent bundle TM is stably trivial, meaning that for some trivial bundle E the Whitney sum TM\oplus E is trivial. For example, the n-dimensional sphere Sn is framed for all n, but parallelizable only for (by results of Bott-Milnor and Kervaire).
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A global non-equilibrium state can be stably stationary only if it is maintained by exchanges between the system and the outside. For example, a globally-stable stationary state could be maintained inside the glass of water by continuously adding finely powdered ice into it in order to compensate for the melting, and continuously draining off the meltwater. Natural transport phenomena may lead a system from local to global thermodynamic equilibrium. Going back to our example, the diffusion of heat will lead our glass of water toward global thermodynamic equilibrium, a state in which the temperature of the glass is completely homogeneous.
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The company has developed hybrid salmon, trout, and tilapia designed to grow faster than traditional fish. Only the salmon has progressed to government (Canada, United States) approvals. Their hybrid Atlantic salmon incorporates a gene from a Chinook salmon, which bears a single copy of the stably integrated α-form of the opAFP-GHc2 gene construct at the α-locus in the EO-1α line (Ocean Pout AKA Eel). AquaBounty has patented and trademarked this fish as the AquAdvantage salmon, a sterile Atlantic salmon female that can grow to market size in half the time of conventional salmon.
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Triparental mating is a form of Bacterial conjugation where a conjugative plasmid present in one bacterial strain assists the transfer of a mobilizable plasmid present in a second bacterial strain into a third bacterial strain. Plasmids are introduced into bacteria for such purposes as transformation, cloning, or transposon mutagenesis. Triparental matings can help overcome some of the barriers to efficient plasmid mobilization. For instance, if the conjugative plasmid and the mobilizable plasmid are members of the same incompatibility group they do not need to stably coexist in the second bacterial strain for the mobilizable plasmid to be transferred.
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An examination of de novo genes in A. thaliana found that they are both hypermethylated and generally depleted of histone modifications. In agreement with either the proto-gene model or contamination with non-genes (see below), methylation levels of de novo genes were intermediate between established genes and intergenic regions. The methylation patterns of these de novo genes are stably inherited, and methylation levels were highest, and most similar to established genes, in de novo genes with verified protein-coding ability. In the pathogenic fungus Magnaporthe oryzae, less conserved genes tend to have methylation patterns associated with low levels of transcription.
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After the helium shell runs out of fuel, the TP- AGB starts. Now the star derives its energy from fusion of hydrogen in a thin shell, which restricts the inner helium shell to a very thin layer and prevents it fusing stably. However, over periods of 10,000 to 100,000 years, helium from the hydrogen shell burning builds up and eventually the helium shell ignites explosively, a process known as a helium shell flash. The luminosity of the shell flash peaks at thousands of times the total luminosity of the star, but decreases exponentially over just a few years.
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Dynamic electrostatic interactions between its positively charged basic sequence with negative charges at the inner leaflet of the plasma membrane account for its predominant localization at the cell surface at steady-state. NRAS and HRAS are further processed on the surface of the Golgi apparatus by palmitoylation of one or two Cys residues, respectively, adjacent to the CaaX box. The proteins thereby become stably membrane anchored (lipid-rafts) and are transported to the plasma membrane on vesicles of the secretory pathway. Depalmitoylation by acyl-protein thioesterases eventually releases the proteins from the membrane, allowing them to enter another cycle of palmitoylation and depalmitoylation.
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Due to the length of the sail plan relative to the hull, and the long keel, the Spray was capable of self-steering (unlike faster modern craft), and he balanced it stably on any course relative to the wind by adjusting or reefing the sails and by lashing the helm fast. He sailed west across the Indian Ocean without once touching the helm. More than three years later, on June 27, 1898, he returned to Newport, Rhode Island, having circumnavigated the world, a distance of more than 46,000 miles (74,000 km). Slocum's return went almost unnoticed.
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Conversely, lentivirus are also used to stably over-express certain genes, thus allowing researchers to examine the effect of increased gene expression in a model system. Another common application is to use a lentivirus to introduce a new gene into human or animal cells. For example, a model of mouse hemophilia is corrected by expressing wild-type platelet-factor VIII, the gene that is mutated in human hemophilia. Lentiviral infection has advantages over other gene-therapy methods including high-efficiency infection of dividing and non-dividing cells, long-term stable expression of a transgene, and low immunogenicity.
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In the genetic code, there are 43 = 64 possible codons (tri-nucleotide sequences). For translation, each of these codons requires a tRNA molecule with an anticodon with which it can stably base pair anticodon. If each tRNA molecule is paired with its complementary mRNA codon using canonical Watson-Crick base pairing, then 64 types (species) of tRNA molecule would be required. In the standard genetic code, three of these 64 mRNA codons (UAA, UAG and UGA) are stop codons. These terminate translation by binding to release factors rather than tRNA molecules, so canonical pairing would require 61 species of tRNA.
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Around that time stone circles began to be built in the coastal and lowland areas towards the north of the United Kingdom. The Langdale axe industry in the Lake District appears to have been an important early centre for circle building, perhaps because of its economic power. Many had closely set stones, perhaps similar to the earth banks of henges; others were made from boulders placed stably on the ground rather than standing stones held erect by a foundation trench. Recent research shows that two oldest stone circles in Britain (Stenness and Callanish) were constructed to align with solar and lunar positions.
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During the second step of splicing in eukaryotic cells, the EJC is deposited approximately 20-24 nucleotides from the 5’ end upstream of the splice junction (where two exons are joined), when the lariat has formed and the exons are ligated together. The binding of the EJC to the mRNA occurs in a sequence independent manner, to form the mature messenger ribonucleoprotein (mRNP). The EJC remains stably bound to this mRNP as it is exported out of the nucleus and into the cytoplasm. Protein components are either bound to or released by the EJC as it is transported.
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Unlike thermally initiated phosphaalkyne oligomerization reactions, transition metals and main group metals are capable of oligomerizing phosphaalkynes in a controlled manner, and have led to the isolation of phosphaalkyne dimers, trimers, tetramers, pentamers, and even hexamers. A nickel complex is capable of catalytically homocoupling tBu-C≡P to yield a diphosphatetrahedrane. Some of the reported phosphaalkyne oligomers generated upon treatment of a phosphaalkyne (usually tBu-C≡P) with a transition metal or main group metal complex. Note that several of these species are unstable in their free forms, and instead exist stably only when bound to a transition metal.
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A medieval scandinavian ring with the inscription "for allah". In 844 Vikings tried to attack Seville but were repulsed by the Andulusi army using greek fire. It is said a minority of the Vikings settled in Seville after the defeat, converted to islam, and taught the city their way of making cheese. Adb al Rahman would rule stably after his conquest, building major public works, most famously the Cathedral of Córdoba, and helping urbanize the empire while defending from invaders, including quashing numerous rebellions, and even decisively defeating invasion by Charlemagne (which would later inspire the epic Chanson de Roland).
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Two distinct variants, S and L, were identified in the population designated Ara-2 at 18,000 generations based on their formation of small and large colonies, respectively. Clones of the S and L types could co-exist stably in co-culture with each other, indicating they occupied distinct niches in the population. This was verified by the finding that the L type had an advantage during growth on glucose, but that S had an advantage during stationary phase, after glucose had run out. The two types were found to have initially evolved prior to 6,000 generations, and then co-existed thereafter.
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One of Chatterjee's most notable publications is from 1999, and she researched the use of a "single stranded AAV, replication-defective nonpathogenic human parvovirus with a 4.7kb DNA genome with a palindromic inverted terminal repeats" This process REQUIRES the use of an adenovirus for the DNA to enter the cell and cause infection, thus being stably integrated into the cells DNA genome in a specific place. This study showed that the AAV vector was successful at efficiently transferring DNA into nondividing cells. Another publication that Chatterjee researched and featured in, regarded the effective transduction of CD34+ cells. They found that AAV transduction gave way to altered viral chromosomal integration.
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Toronto, ON. For crossings of large bodies of water, wide freeways, or valleys, where the span width of the conductors is very long, specific constructions must be used to achieve a wider distance between the conductors, mostly to prevent short-circuits which may occur when conductors come in contact with one another due to wind or other interferences. These towers may be built as H-frame towers, or may have each conductor placed on a single tower or mast. In every case, these towers are built more stably than most of the other towers used, as the wide span between towers means that much greater forces are placed on these towers.
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The ankyrin-repeat sequence motif has been studied using multiple sequence alignment to determine conserved amino acid residues critical for folding and stability. The residues on the wide lateral surface of ankyrin repeat structures are variable, often hydrophobic, and involved mainly in mediating protein–protein interactions. An artificial protein design based on a consensus sequence derived from sequence alignment has been synthesized and found to fold stably, representing the first designed protein with multiple repeats. More extensive design strategies have used combinatorial sequences to "evolve" ankyrin-repeats that recognize particular protein targets, a technique that has been presented as an alternative to antibody design for applications requiring high-affinity binding.
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These rains then flow northward and are discharged into the Eastern Mediterranean, where the large influx of nutrient rich fresh water causes a steep vertical salinity gradient. As a result, thermohaline convection is shut off and the water column becomes stably stratified. Once this stable stratification occurs, bottom waters in the Eastern Mediterranean quickly become depleted in oxygen and the large influx of pelagic organic matter from the nutrient rich surface waters is preserved as sapropel formations. One of the key pieces of evidence linking the formation of sapropels to enhance discharge from the Nile River is the fact that they have occurred during both interglacial and glacial periods.
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Thanks to her, a powerful school of philosophy has been formed in Lugansk. Philosophy Department of Volodymyr Dahl East Ukrainian National University is annually qualifying specialists in philosophy and analytics. Scientific Council for defending Ph. D. and D. Sc. dissertations in Aesthetics, Philosophical Anthropology and Philosophy of Culture is stably working for 10 years. As a Head of the Institute of Philosophy and Psychology V. Suchantseva is pointing out the following: “Aesthetics is our strongest faculty school, which is considered to be the best in Ukraine. There are eight Doctors of Science teaching philosophy and aesthetics in our department, whereas Taras Shevchenko National University of Kyiv has only two“.
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There are still difficulties with this dynamo theory, including the fact that Mercury has a slow, 59-day-long rotation that could not have made it possible to generate a magnetic field. This dynamo is probably weaker than Earth's because it is driven by thermo-compositional convection associated with inner core solidification. The thermal gradient at the core–mantle boundary is subadiabatic, and hence the outer region of the liquid core is stably stratified with the dynamo operating only at depth, where a strong field is generated. Because of the planet's slow rotation, the resulting magnetic field is dominated by small-scale components that fluctuate quickly with time.
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Ophiocordyceps camponoti-balzani is a species of fungus that parasitizes insect hosts of the order Hymenoptera, primarily ants. It was first isolated from Viçosa, Minas Gerais (Atlantic Forest), on Camponotus balzani. This species was formerly thought to be Ophiocordyceps unilateralis, which has subsequently been divided into four species. O. camponoti-balzani infects ants, and eventually kills the hosts after they move to an ideal location for the fungus to spread its spores. This has earned the species names such as “zombie fungus”, given the fungus has been observed to cause its hosts to bite hard into the substrate it stands on, so that the fungus can then stably grow.
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An HTH motif typically recognizes the DNA major groove. However, the distance between the DNA recognition helices of the two HTH motifs in the Fis homodimer is 25 Å, that is ~ 8 Å shorter than the pitch of a canonical B-DNA, indicating that the protein must bend or twist DNA to bind stably. Consistently, the crystal structure of Fis- DNA complexes shows that the distance between the recognition helices remains unchanged whereas DNA curves in the range of 60-75 degree. There are 1464 Fis binding regions distributed across the E. coli genome and a binding motif, identified computationally, matches with the known 15-bp motif.
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Moreover, Roscosmos's top officials believed Fobos-Grunt to be functional, stably oriented and charging batteries through its solar panels. In a late November 2011 interview, the service manager of the European Space Agency for Fobos-Grunt, Wolfgang Hell, stated that Roscosmos had a better understanding of the problem with the spacecraft, saying they reached the conclusion that they have some kind of power problem on board. ESA failed to communicate with the space probe in all of the five opportunities the agency had between 28 and 29 November. During those occasions the spacecraft did not comply with orders to fire the engines and raise its orbit.
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Centromeres are conventionally defined by dark-staining heterochromatin which consists of the primary constriction site—this convention exists because heterochromatin is usually found flanking the centromere. With this in mind, centromeric heterochromatin was found on the bisatellited and ring markers, but not on the mar del(10) marker. However, mar del(10) was still able to stably segregate in vivo and in vitro which implied the presence of a functional centromere and kinetochore. There has been an assumption that centromeric heterochromatin is just as important as the kinetochore in segregating and stabilizing chromosomes, because heterochromatin is associated with protein recruitment and has the defining ability to silence gene expression.
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The structure shown is that of myoglobin, PDB id: 1mbn. The goal of protein design is to find a protein sequence that will fold to a target structure. A protein design algorithm must, thus, search all the conformations of each sequence, with respect to the target fold, and rank sequences according to the lowest- energy conformation of each one, as determined by the protein design energy function. Thus, a typical input to the protein design algorithm is the target fold, the sequence space, the structural flexibility, and the energy function, while the output is one or more sequences that are predicted to fold stably to the target structure.
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Limiting similarity (informally "limsim") is a concept in theoretical ecology and community ecology that proposes the existence of a maximum level of niche overlap between two given species that will allow continued coexistence. This concept is a corollary of the competitive exclusion principle, which states that, controlling for all else, two species competing for exactly the same resources cannot stably coexist. It assumes normally-distributed resource utilization curves ordered linearly along a resource axis, and as such, it is often considered to be an oversimplified model of species interactions. Moreover, it has theoretical weakness, and it is poor at generating real-world predictions or falsifiable hypotheses.
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The minor groove presents a near-perfect complement for an inserted base. This allows for optimal van der Waals contacts, extensive hydrogen bonding and hydrophobic surface burial, and creates a highly energetically favorable interaction. Because minor groove triples are capable of stably packing a free loop and helix, they are key elements in the structure of large ribonucleotides, including the group I intron, the group II intron, and the ribosome. Although the major groove of standard A-form RNA is fairly narrow and therefore less available for triplex interaction than the minor groove, major groove triplex interactions can be observed in several RNA structures.
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EF-G in pathogenic bacteria can be inhibited by antibiotics that prevent EF-G from binding to the ribosome, carrying out translocation or dissociating from the ribosome. For example, the antibiotic thiostrepton prevents EF-G from binding stably to the ribosome, while the antibiotics dityromycin and GE82832 inhibit the activity of EF-G by preventing the translocation of the A site tRNA. Dityromycin and GE82832 do not affect the binding of EF-G to the ribosome, however. The antibiotic fusidic acid is known to inhibit Staphylococcus aureus and other bacteria by binding to EF-G after one translocation event on the ribosome, preventing EF-G from dissociating.
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The phenotypic differences hypothesis proposes that individuals differ in their ability to use each foraging skill and stably specialize on the most profitable one. The pattern of specialization is expected to be stable although the number of individuals that use a given skill depends on the phenotypic composition of the flock. The frequency dependent choice hypothesis also proposes that individuals specialize on the most profitable skill, but the profitability of each alternative decreases as the number of phenotypically identical foragers gradually specialize on each skill when initially given two equally profitable alternatives. At equilibrium, individual payoffs should be independent of the pattern of specialization.
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The discovery of artificially induced competence in bacteria allow bacteria such as Escherichia coli to be used as a convenient host for the manipulation of DNA as well as expressing proteins. Typically plasmids are used for transformation in E. coli. In order to be stably maintained in the cell, a plasmid DNA molecule must contain an origin of replication, which allows it to be replicated in the cell independently of the replication of the cell's own chromosome. The efficiency with which a competent culture can take up exogenous DNA and express its genes is known as transformation efficiency and is measured in colony forming unit (cfu) per μg DNA used.
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From the 2012-13 season, the club changed logo and name to Rugby San Donà, the club stably takes part to the Eccellenza championship under the Lafert San Donà name, due to sponsorship. During the 2017-18 season, the team arrives fifth in the championship ladder, almost making it to the play-off semifinals, and won the Trofeo Eccellenza in the final against Fiamme Oro with the score 24-0. In the titular team which entered to the pitch at Battaglini in Rovigo, led by the coach Zane Ansell, featuring the Italian representative players Paul Derbyshire, Jaco Erasmus, Andrea Pratichetti, who scored a try, and Matteo Falsaperla, Italy sevens captain.
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Sometimes it is difficult to accurately distinguish individual chromosomes based on chromosome length, arm ratio, and C-banding pattern. Fosmids can be used as reliable cytological markers for individual chromosome identification and fluorescent in situ hybridization based metaphase chromosome karyotypes can be used to show whether the positions of these fosmids were successfully constructed.Liu, C 2010 Karyotyping in Melon (Cucumis melo L.) by Cross- Species Fosmid Fluorescence in situ Hybridization, CYTOGENETIC AND GENOME RESEARCH The fosmid system is excellent for rapidly creating chromosome- specific mini-BAC libraries from flow-sorted chromosomal DNA. The major advantage of Fosmids over other cosmid systems lies in its capability of stably propagating human DNA fragments.
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Four-speaker setups are the most economical way of reproducing first-order horizontal material, and a rectangular layout is most easily fit into a living room, which makes these setups the most common in domestic environments. With rectangles, there is a localisation performance trade-off: the short sides will localise more stably than the square, the long sides worse. Consequently, for predominantly frontal sound stages, Benjamin, Lee, and Heller (2008) have observed a preference for rectangular layouts over squares.Eric Benjamin, Richard Lee, and Aaron Heller, Localisation in Horizontal-only Ambisonic Systems, 121st AES Convention, San Francisco 2006 All legacy domestic hardware decoders supported rectangular layouts, usually with variable aspect ratios.
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During the first half of the 20th century, the monks of St. Meinrad Archabbey in Indiana had operated four small mission churches in the Dakotas, two in North Dakota and two in South Dakota. Their purpose was to serve the local population of the region, primarily the Native Americans on the Indian reservations, for whom they also operated several schools. In 1949 the monastic chapter decided to establish a new monastery to establish their presence more stably in that region and thereby to permit the full expression of their monastic lives. To this end, Archabbot Ignatius Esser, O.S.B., assigned four monks to scout the area.
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Drawing showing how a Kapitza pendulum can be constructed: a motor rotates a crank at a high speed, the crank vibrates a lever arm up and down, which the pendulum is attached to with a pivot. Kapitza's pendulum or Kapitza pendulum is a rigid pendulum in which the pivot point vibrates in a vertical direction, up and down. It is named after Russian Nobel laureate physicist Pyotr Kapitza, who in 1951 developed a theory which successfully explains some of its unusual properties.; The unique feature of the Kapitza pendulum is that the vibrating suspension can cause it to balance stably in an inverted position, with the bob above the suspension point.
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Based on position and shape, the three points of contact may be so close that it appears to be stably resting on only a single point. A rock at the top of a sculpture, for example, can have a rounded shape, but be approximately flat and oriented horizontally, and be in a state of equilibrium. The stability of a structure is also affected by the friction between rocks, especially when rocks are set upon one another at an angle. A structure may topple over (collapse) based on the magnitude of other phenomena, such as wind, rain, snow, and localized ground vibration, or general seismic activity.
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Experiments led by Randall Hulet at Rice University from 1995 through 2000 showed that lithium condensates with attractive interactions could stably exist up to a critical atom number. Quench cooling the gas, they observed the condensate to grow, then subsequently collapse as the attraction overwhelmed the zero-point energy of the confining potential, in a burst reminiscent of a supernova, with an explosion preceded by an implosion. Further work on attractive condensates was performed in 2000 by the JILA team, of Cornell, Wieman and coworkers. Their instrumentation now had better control so they used naturally attracting atoms of rubidium-85 (having negative atom–atom scattering length).
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The functional group, the spacer and the lipid tail components of the FSL Kode construct can each be individually designed resulting in FSL Kode constructs with specific biological functions. The functional head group is usually the bioactive component of the construct and the various spacers and lipids influence and effect its presentation, orientation and location on a surface. Critical to the definition of an FSL Kode construct is the requirement to be dispersible in water, and spontaneously and stably incorporate into cell membranes. Other lipid bioconjugates that include components similar to FSLs but do not have these features are not termed as Function-Spacer-Lipid Kode constructs.
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It is now well-accepted that chromatin is not randomly organized in the cell nucleus, but the positions of each chromosome domain relative to its neighboring domains is characteristic of different cell types, and after this geography is established in each newly formed cell, the chromosome domains do not move appreciably until the next cell division.Lanctot C, Cheutin T, Cremer M, Cavalli G, Cremer T (2007) Dynamic genome architecture in the nuclear space: regulation of gene expression in three dimensions. Nat Rev Genet 8: 104-115.Walter J, Schermelleh L, Cremer M, Tashiro S, Cremer T (2003) Chromosome order in HeLa cells changes during mitosis and early G1, but is stably maintained during subsequent interphase stages.
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Ultramafic rocks such as peridotite and dunite can be residues left after extraction of magmas, and typically they are more enriched in olivine after extraction of partial melts. Olivine and high pressure structural variants constitute over 50% of the Earth's upper mantle, and olivine is one of the Earth's most common minerals by volume. The metamorphism of impure dolomite or other sedimentary rocks with high magnesium and low silica content also produces Mg-rich olivine, or forsterite. Fe-rich olivine fayalite is relatively much less common, but it occurs in igneous rocks in small amounts in rare granites and rhyolites, and extremely Fe-rich olivine can exist stably with quartz and tridymite.
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PEG- mediated transformation however, is notoriously time consuming, very technical and labor intensive as it requires the removal of the cell wall which is a key protective structural component of the plant cell. Interestingly, a paper released in 2018 has described a successful plastid transformation of the chloroplast from the microalgae species N. oceanica and C. reinhardtii through electroporation. Whilst no study has been attempted yet for plastid transformation of higher plants using electroporation, this could be an interesting area of study for the future. In order to persist and be stably maintained in the cell, a plasmid DNA molecule must contain an origin of replication, which allows it to be replicated in the cell independently of the chromosome.
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Four varieties of the Belgian Shepherd are recognised as separate breeds by the New Zealand Kennel Club Chihuahua mix and purebred Great Dane Groups of owners that have dogs of the same breed and have an interest in dog breeding can form national Kennel clubs. Kennel Clubs maintain breed standards, record pedigrees in a breed registry (or studbook), and issue the rules for conformation dog shows and trials and accreditation of judges. They often serve as registries, which are lists of adult purebred dogs and lists of litters of puppies born to purebred parents. A dog breed is represented by a sufficient number of individuals to stably transfer its specific characteristics over generations.
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DiCo, an acronym for Diritti e doveri delle persone stabilmente conviventi (Rights and Duties for Stably Cohabiting People), refers to a bill presented to the Senate of Italian Parliament on 8 February 2007 by the Prodi II Cabinet, concerning a number of rights for heterosexual and homosexual cohabiting couples. The proposal falls short of the civil unions introduced in several other European countries in recent years. The main goal of the DiCo bill was to give cohabiting partners, irrespective of their sexual orientation, inheritance and alimony rights (after nine and three years of living together, respectively). It would also allow one partner to make decisions on funeral arrangements and organ donation when the other dies.
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However, when 2 or more plasmids are used, each plasmid needs to use a different antibiotic selection as well as a different origin of replication, otherwise one of the plasmids may not be stably maintained. Many commonly used plasmids are based on the ColE1 replicon and are therefore incompatible with each other; in order for a ColE1-based plasmid to coexist with another in the same cell, the other would need to be of a different replicon, e.g. a p15A replicon-based plasmid such as the pACYC series of plasmids. Another approach would be to use a single two-cistron vector or design the coding sequences in tandem as a bi- or poly-cistronic construct.
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The principle maintains that two species with the same ecological niches cannot stably coexist. That is to say, when two species compete for identical resource access, one will be competitively superior and it will ultimately supplant the other. Over the next half century, limiting similarity slowly emerged as a natural outgrowth of this principle, aiming (but not necessarily succeeding) to be more quantitative and specific. Noted ecologist and evolutionary biologist David Lack said retrospectively that he had already begun to mull around with the ideas of limiting similarity as early as the 1940s, but it wasn't until the end of the 1950s that the theory began to be built up and articulated.
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This is caused by the distribution of the chloroplasts throughout the extensively branched gut. At first the slug needs to feed continually on algae to retain the chloroplasts, but over time the chloroplasts become more stably incorporated into the cells of the gut enabling the slug to remain green without further feeding. Some Elysia chlorotica slugs have even been known to be able to use photosynthesis for up to a year after only a few feedings. The chloroplasts of the algae are incorporated into the cell through the process of phagocytosis in which the cells of the sea slug engulf the cells of the algae and make the chloroplasts a part of its own cellular content.
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This causes the outer layers to expand even further and generates a strong convective zone that brings heavy elements to the surface in a process called the first dredge-up. This strong convection also increases the transport of energy to the surface, the luminosity increases dramatically, and the star moves onto the red-giant branch where it will stably burn hydrogen in a shell for a substantial fraction of its entire life (roughly 10% for a Sun-like star). The core continues to gain mass, contract, and increase in temperature, whereas there is some mass loss in the outer layers.Evolution of Stars and Stellar Populations, Maurizio Salaris and Santi Cassisi, Chichester, UK: John Wiley & Sons, Ltd.
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With older instruments it was necessary to adjust the vibration amplitude according to the weight of the test object. However, modern instruments contain a built-in reference accelerometer and closed-loop control, with which the amplitude is kept constant up to a maximum specified weight of test object. Older models can be used to calibrate objects weighing up to a maximum of approximately 100 g, whereas the latest instruments can work stably with test objects weighing over 500 g. Modern vibration calibrator for frequencies between 16 and 1280 Hz Vibration calibrators are most often used for testing and checking vibration sensors and measuring instruments at the site of their operation and are, therefore, usually transportable and battery operated.
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At room temperature, the DNA will exist stably in a double-stranded form. As the temperature is increased, the strands begin to separate (melting), and the speed at which they move through the gel decreases drastically. Critically, the temperature at which melting occurs depends on the sequence (GC basepairs are more stable than AT due to stacking interactions, not due to the difference in hydrogen bonds (there are three hydrogen bonds between a cytosine and guanine base pair, but only two between adenine and thymine)), so TGGE provides a "sequence dependent, size independent method" for separating DNA molecules. TGGE separates molecules and gives additional information about melting behavior and stability (Biometra, 2000).
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Similarly to the alkali metals, ammonia reacts with hydrochloric acid to form the salt ammonium chloride. The ammonium ion () has very similar properties to the heavier alkali metals, acting as an alkali metal intermediate between potassium and rubidium, and is often considered a close relative. For example, most alkali metal salts are soluble in water, a property which ammonium salts share. Ammonium is expected to behave stably as a metal ( ions in a sea of delocalised electrons) at very high pressures (though less than the typical pressure where transitions from insulating to metallic behaviour occur around, 100 GPa), and could possibly occur inside the ice giants Uranus and Neptune, which may have significant impacts on their interior magnetic fields.
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Schematic representation of the pBR322 plasmid, one of the first plasmids widely used as a cloning vector. A cloning vector is a small piece of DNA that can be stably maintained in an organism, and into which a foreign DNA fragment can be inserted for cloning purposes. The cloning vector may be DNA taken from a virus, the cell of a higher organism, or it may be the plasmid of a bacterium. The vector therefore contains features that allow for the convenient insertion or removal of a DNA fragment to or from the vector, for example by treating the vector and the foreign DNA with a restriction enzyme that cuts the DNA.
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After a sperm fertilizes an ovum to form a zygote, rapid DNA demethylation of the paternal DNA and slower demethylation of the maternal DNA occurs until formation of a morula which has almost no methylation. After the blastocyst is formed, methylation can begin, and with formation of the epiblast a wave of methylation then takes place until the implantation stage of the embryo. Another period of rapid and almost complete demethylation occurs during gametogenesis within the primordial germ cells (PGCs). Other than the PGCs, in the post-implantation stage, methylation patterns in somatic calls are stage- and tissue-specific with changes that presumably define each individual cell type and last stably over a long time.
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Note that the name of the gene "speA" is italicized; the name of the toxin "speA" is not italicized. Erythrogenic toxin A converts a harmless, non-virulent strain of Streptococcus pyogenes to a virulent strain through lysogeny, a life cycle which is characterized by the ability of the genome to become a part of the host cell and be stably maintained there for generations. Phages with a lysogenic life cycle are also called temperate phages. Bacteriophage T12, proposed member of family Siphoviridae including related speA-carrying bacteriophages, is also a prototypic phage for all the speA-carrying phages of Streptococcus pyogenes, meaning that its genome is the prototype for the genomes of all such phages of S. pyogenes.
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Paine and Syms 2012, p. 513. On the underside of the buoyancy tanks, a total of five 21-inch platforms (known as 'elephant feet') were positioned so that the craft could stably rest on three of them. Fuel was contained within flexible bags located at all four corners; the craft could be trimmed by intentionally redistributing fuel between the fore and aft tanks to better match the load and prevailing weather conditions. The stern of the craft featured a sizeable set of doors for the loading and unloading of vehicles onto the car deck as well as all four of the exhausts for the Proteus engines, another set of loading doors were present on the front as well.
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Personalized medicine in the context of pharmacomicrobiomics refers to the ability to predict an individual’s response to a xenobiotic based on the composition of their gut microbiome. However, current omics approaches investigating microbiome composition using metagenomic sequencing after xenobiotic treatment are sparse. Instead, research efforts have focused predominantly on modeling changes in microbial composition in different disease states. Future research efforts should combine knowledge relating to what microbes preferentially metabolize certain compounds (garnered from in vitro studies) with the identification of species abundance to predict drug tolerance in patients. However, modeling a microbe’s interaction with a particular xenobiotic may not stably predict interactions, as the genomes of microbes are continually reshuffled through horizontal gene transfer.
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Embryonic stem cells capable of contributing to the germline of livestock species such as sheep have not been isolated. The production of Dolly the Sheep and also Megan and Morag, the two sheep that led to the production of Dolly, demonstrated that viable sheep can be produced by nuclear transfer from a variety of somatic cell types which have been cultured in vitro. Polly and Molly represented the further step in which somatic cells were cultured in vitro, just as in the case with the previous sheep. However, in this case they were transfected with foreign DNA, and the transfected cells which stably integrated this new piece of genetic information were selected.
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The whole group H2(X, Gm) can be viewed as classifying the gerbes over X with structure group Gm. For smooth projective varieties over a field, the Brauer group is a birational invariant. It has been fruitful. For example, when X is also rationally connected over the complex numbers, the Brauer group of X is isomorphic to the torsion subgroup of the singular cohomology group H3(X, Z), which is therefore a birational invariant. Artin and Mumford used this description of the Brauer group to give the first example of a unirational variety X over C that is not stably rational (that is, no product of X with a projective space is rational).
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But when active controls were used to keep the vortex stably in place they found the results "really encouraging". Such scientific experimental work seems to contradict the idea that the original KF airfoil will find a simple practical application in the world of full-size aircraft. But the basic idea of the stepped wing has mutated, and is now bound up with a new body of research into actively controlling the airflow over a wing's surface with new mechanisms unthinkable 50 years ago. The case study conducted as a part of this research focuses on the UAV RQ-2 Pioneer employed in a stepped airfoil configuration by comparing its aerodynamic characteristics with the conventional NACA 4415 airfoil originally used on this aircraft.
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She has won many cartoon awards home and abroad and participated in many international art interchange activities. Now lives in Dali, Yunnan. Since 2004, the cartoon books, "My Way" series have been successively published, and, at present, they have been authorized to publish in France, Malaysia and other countries. Meanwhile, the "My Way"series have continuously hit the best-selling list of literature books in every well-known book city, and been recognized and loved by the readers with its sales volume stably retaining the first place of inland cartoon books. With her fresh and warm drawing style, appealing colors, and mild and sorrowful words, Jidi is honored as "emotional color magician" and cartoonist producing cartoon books warming people’s hearts.
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The Levitron brand top is an example of spin-stabilized magnetic levitation A magnet or properly assembled array of magnets with a toroidal field can be stably levitated against gravity when gyroscopically stabilized by spinning it in a second toroidal field created by a base ring of magnet(s). However, this only works while the rate of precession is between both upper and lower critical thresholds—the region of stability is quite narrow both spatially and in the required rate of precession. The first discovery of this phenomenon was by Roy M. Harrigan, a Vermont inventor who patented a levitation device in 1983 based upon it. Several devices using rotational stabilization (such as the popular Levitron branded levitating top toy) have been developed citing this patent.
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CFSE is commonly confused with carboxyfluorescein diacetate succinimidyl ester (CFDA-SE), although they are not strictly the same molecule; CFDA-SE, due to its acetate groups, is highly cell permeable, while CFSE is much less so. As CFDA-SE, which is non- fluorescent, enters the cytoplasm of cells, intracellular esterases remove the acetate groups and convert the molecule to the fluorescent ester. CFSE was originally developed as a fluorescent dye that could be used to stably label lymphocytes and track their migration within animals for many months. Subsequent studies revealed that the dye can be used to monitor lymphocyte proliferation, both in vitro and in vivo, due to the progressive halving of CFSE fluorescence within daughter cells following each cell division.
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It can be suspended stably in this inverted position by using a control system to monitor the angle of the pole and move the pivot point horizontally back under the center of mass when it starts to fall over, keeping it balanced. The inverted pendulum is a classic problem in dynamics and control theory and is used as a benchmark for testing control strategies. It is often implemented with the pivot point mounted on a cart that can move horizontally under control of an electronic servo system as shown in the photo; this is called a cart and pole apparatus.C.A. Hamilton Union College Senior Project 1966 Most applications limit the pendulum to 1 degree of freedom by affixing the pole to an axis of rotation.
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Mutants such as cca1-1 plants, which lack CCA1 protein, show short period phenotypes for the expression of several genes when assayed under constant light conditions. They also have a period 3 hours shorter than that of the wild-type plant, which demonstrates that expression of LHY, its homolog, cannot fully compensate for the loss of the function of CCA1. Plants that have lost function of LHY and CCA1 (lhy;cca1) lost the ability to stably maintain circadian rhythm and other output phenomena. In one study, lhy;cca1 show photoperiod- insensitive early flowering under long- day (16 hours of light/ 8 hours of dark) conditions and short day (8 hours of light, 16 hours of dark conditions), and arrhythmicity under constant light conditions.
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These features consistently and reliably identify a very specific subset of neurons in the dorsolateral pons, named the pre-locus coeruleus, or "pre-LC." Some investigators have used other terms including "precoeruleus," "peri5Me," and "pericoeruleus" to refer less specifically to regions of the brainstem anterior to the LC, but the term pre-LC very specifically refers to the group of neurons as defined above. Subsequently, it was discovered that every c-Fos- positive neuron in the pre-LC (after sodium deprivation) also expresses the transcription factor FOXP2. Given that sodium deprivation is a time-consuming experimental manipulation, and that FoxP2 is stably expressed without any experimental manipulation, this transcription factor can serve as a useful surrogate marker for labeling pre-LC neurons.
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Perhaps further studying of ring chromosomes and diseases, from the perspective of neocentromere formation, may shed light on mechanisms of tumor formation due to chromosome abnormalities. For example, one may question whether the ring chromosomes present in tumors contain a neocentromere following a Class II deletion, because the neocentromere may or may not be present on the ring. As well as autosomes, human neocentromeres have also been observed in sex chromosomes, and correlate with some sex-linked diseases. In 1999, analysis of a neocentromere in the Y chromosome with a constriction site in the amniocytes of a 38-year-old woman, and in her husband and brother-in-law served as experimental evidence that neocentromeres can be stably transmitted through meiosis into the next generation.
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It was reported that Zoé Alejandro Robledo, the director of the Mexican Social Security Institute (IMSS) and three other top bureaucrats of the institution were infected with coronavirus. The traffic light map for June 8–14 showed the entire country in red and Hugo López-Gatell emphatically denied on June 8 that the country could now return to normality. The states of Tamaulipas, Oaxaca, and Quintana Roo were stable but still "stably high." Guerrero, Yucatán, and Querétaro had lower contagion rates than 14 days earlier, but López-Gatell warned of a possible rebound. The Institute for Health Metrics and Evaluation of the University of Washington in Seattle projects between 37,397 and 75,516 deaths due to the coronavirus in Mexico by August 4.
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Once secretory proteins are formed, the ER membrane separates them from the proteins that will remain in the cytosol. Secretory proteins depart from the ER enfolded in the membranes of vesicles that bud like bubbles from the transitional ER. These vesicles in transit to another part of the cell are called transport vesicles. An alternative mechanism for transport of lipids and proteins out of the ER are through lipid transfer proteins at regions called membrane contact sites where the ER becomes closely and stably associated with the membranes of other organelles, such as the plasma membrane, Golgi or lysosomes. In addition to making secretory proteins, the rough ER makes membranes that grows in place from the addition of proteins and phospholipids.
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The first evidence that neurogenesis occurs in certain regions of the adult mammalian brain came from [3H]-thymidine labeling studies conducted by Altman and Das in 1965 which showed postnatal hippocampal neurogenesis in young rats. In 1989, Sally Temple described multipotent, self- renewing progenitor and stem cells in the subventricular zone (SVZ) of the mouse brain. In 1992, Brent A. Reynolds and Samuel Weiss were the first to isolate neural progenitor and stem cells from the adult striatal tissue, including the SVZ — one of the neurogenic areas — of adult mice brain tissue. In the same year the team of Constance Cepko and Evan Y. Snyder were the first to isolate multipotent cells from the mouse cerebellum and stably transfected them with the oncogene v-myc.
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Chemical Activated LUciferase gene eXpression (CALUX) is a ligand-dependent nuclear receptor-based bioassay used in the detection of specific chemicals or classes of chemicals in samples. It consists of a modified cell line that has been stably transfected with a DNA construct with a luciferase reporter gene under control of receptor-specific DNA response elements that can stimulate transcription of the inserted luciferase gene and produce the light-generating enzyme which can be easily measured. The DNA response elements can be varied in order to provide binding sites for other receptors that are regulated by a chemical or class of chemicals of interest that want to be detected. Thus, numerous CALUX bioassays have been developed for detection of diverse chemicals of interest.
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Contemporary documents call her marquess or lady marquess of Pembroke; this reflects Tudor spelling. Marquesates were relatively new in 16th-century England, and the English translations of French marquis/marquise were spelled even less stably than most Tudor orthography; many forms were used for each. A male peer was marquys, marquoys, marquess and so on; his wife would be marquess, marquesse, marquisess and so on, the same ending as duchess; the resulting confusion was sometimes clarified by such phrases as lady marquess; the modern distinction, by which the wife is marchioness, was imported from Latin in her daughter's reign. The OED and The Complete Peerage (Vol X., p. 402) take Boleyn's title as the feminine sense of marquess; some biographers, such as Fraser, p.
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Static stability means that any small displacement away from a stable equilibrium causes a net force to push it back to the equilibrium point. Earnshaw's theorem proved conclusively that it is not possible to levitate stably using only static, macroscopic, paramagnetic fields. The forces acting on any paramagnetic object in any combinations of gravitational, electrostatic, and magnetostatic fields will make the object's position, at best, unstable along at least one axis, and it can be in unstable equilibrium along all axes. However, several possibilities exist to make levitation viable, for example, the use of electronic stabilization or diamagnetic materials (since relative magnetic permeability is less than one); it can be shown that diamagnetic materials are stable along at least one axis, and can be stable along all axes.
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Conversely, the primary goal of underclocking is to reduce power consumption and the resultant heat generation of a device, with the trade-offs being lower clock speeds and reductions in performance. Reducing the cooling requirements needed to keep hardware at a given operational temperature has knock-on benefits such as lowering the number and speed of fans to allow quieter operation, and in mobile devices increase the length of battery life per charge. Some manufacturers underclock components of battery- powered equipment to improve battery life, or implement systems that detect when a device is operating under battery power and reduce clock frequency accordingly. Underclocking is almost always involved in the latter stages of Undervolting, which seeks to find the highest clock speed that a processor will stably operate at a given voltage.
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These lentiviral vectors are able to efficiently transduce a broad range of cell types and stably integrate into the genome of dividing and non-dividing cells. Third generation lentiviral particles are produced by co-transfecting 293T human embryonic kidney (HEK) cells with: # two packaging plasmids, one encoding Rev and the other Gag and Pol; # an interchangeable envelope plasmid that encodes for an envelope glycoprotein of another virus (most commonly the G protein of vesicular stomatitis virus (VSV-G)); # one or two (depending on the applied library) transfer plasmids, encoding for Cas9 and sgRNA, as well as selection markers. The lentiviral particle-containing supernatant is harvested, concentrated and subsequently used to infect the target cells. The exact protocol for lentiviral production will vary depending on the research aim and applied library.
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The NIH "Roadmap Epigenomics Project", ongoing as of 2016, uses the following definition: "For purposes of this program, epigenetics refers to both heritable changes in gene activity and expression (in the progeny of cells or of individuals) and also stable, long-term alterations in the transcriptional potential of a cell that are not necessarily heritable." In 2008, a consensus definition of the epigenetic trait, a "stably heritable phenotype resulting from changes in a chromosome without alterations in the DNA sequence", was made at a Cold Spring Harbor meeting. The similarity of the word to "genetics" has generated many parallel usages. The "epigenome" is a parallel to the word "genome", referring to the overall epigenetic state of a cell, and epigenomics refers to global analyses of epigenetic changes across the entire genome.
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Castle's work was among the first to attempt to unify the recently rediscovered laws of Mendelian inheritance with Darwin's theory of evolution. Still, it would be almost thirty years until the theoretical framework for evolution of complex traits would be widely formalized. In an early summary of the theory of evolution of continuous variation, Sewall Wright, a graduate student who trained under Castle, summarized contemporary thinking about the genetic basis of quantitative natural variation: "As genetic studies continued, ever smaller differences were found to mendelize, and any character, sufficiently investigated, turned out to be affected by many factors." Wright and others formalized population genetics theory that had been worked out over the preceding 30 years explaining how such traits can be inherited and create stably breeding populations with unique characteristics.
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Under Newton's law of universal gravitation, bodies placed at rest in a central configuration will maintain the configuration as they collapse to a collision at their center of mass. Systems of bodies in a two-dimensional central configuration can orbit stably around their center of mass, maintaining their relative positions, with circular orbits around the center of mass or in elliptical orbits with the center of mass at a focus of the ellipse. These are the only possible stable orbits in three-dimensional space in which the system of particles always remains similar to its initial configuration. More generally, any system of particles moving under Newtonian gravitation that all collide at a single point in time and space will approximate a central configuration, in the limit as time tends to the collision time.
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There, a pool of liquid lithium metal is used as a sort of limiter; the particles hit it and are rapidly cooled, remaining in the lithium. This internal pool is much easier to cool, due to its location, and although some lithium atoms are released into the plasma, its very low mass makes it a much smaller problem than even the lightest metals used previously. As machines began to explore this newly shaped plasma, they noticed that certain arrangements of the fields and plasma parameters would sometimes enter what is now known as the high-confinement mode, or H-mode, which operated stably at higher temperatures and pressures. Operating in the H-mode, which can also be seen in stellarators, is now a major design goal of the tokamak design.
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The data revealed no atmosphere to a surface pressure of 1–2 mPa (10–20 nbar); if it exists, it would have to be far thinner than that of Triton or Pluto. This upper limit is still several times higher than the maximum possible surface pressure of the carbon dioxide, meaning that the measurements place essentially no constraints on parameters of the atmosphere. The peculiar geometry of the Uranian system causes the moons' poles to receive more solar energy than their equatorial regions. Because the vapor pressure of CO2 is a steep function of temperature, this may lead to the accumulation of carbon dioxide in the low-latitude regions of Titania, where it can stably exist on high albedo patches and shaded regions of the surface in the form of ice.
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Also visible is the mutual tidal locking between the two bodies. The Pluto system is highly compact and largely empty: Prograde moons could stably orbit Pluto out to 53% of the Hill radius (the gravitational zone of Pluto's influence) of 6 million km, or out to 69% for retrograde moons. However, only the inner 3% of the region where prograde orbits would be stable is occupied by satellites, and the region from Styx to Hydra is packed so tightly that there is little room for further moons with stable orbits within this region. An intense search conducted by New Horizons confirmed that no moons larger than 4.5 km in diameter exist out to a distances up to 180,000 km from Pluto (6% of the stable region for prograde moons), assuming Charon-like albedoes of 0.38 (for smaller distances, this threshold is still smaller).
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A genus \varphi assigns a number \Phi(X) to each manifold X such that #\Phi(X \sqcup Y) =\Phi(X) + \Phi(Y) (where \sqcup is the disjoint union); #\Phi(X \times Y) =\Phi(X)\Phi(Y); #\Phi(X)=0 if X is the boundary of a manifold with boundary. The manifolds and manifolds with boundary may be required to have additional structure; for example, they might be oriented, spin, stably complex, and so on (see list of cobordism theories for many more examples). The value \Phi(X) is in some ring, often the ring of rational numbers, though it can be other rings such as \Z/2\Z or the ring of modular forms. The conditions on \Phi can be rephrased as saying that \varphi is a ring homomorphism from the cobordism ring of manifolds (with additional structure) to another ring.
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Lastly, Haumea is the goddess of fertility and childbirth, with many children who sprang from different parts of her body; this corresponds to the swarm of icy bodies thought to have broken off the main body during an ancient collision. The two known moons, also believed to have formed in this manner, are thus named after two of Haumea's daughters, Hiʻiaka and Nāmaka. The proposal by the Ortiz team, Ataecina, did not meet IAU naming requirements, because the names of chthonic deities were reserved for stably resonant trans-Neptunian objects such as plutinos that resonate 3:2 with Neptune, whereas Haumea was in an intermittent 7:12 resonance and so by some definitions was not a resonant body. The naming criteria would be clarified in late 2019, when the IAU decided that chthonic figures were to be used specifically for plutinos.
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Crenolanib has been shown to inhibit PDGFRα with an IC50 of 0.4 ng/mL in porcine aortic epithelial cell lines. In Chinese hamster ovary (CHO) cells expressing PDGFRα, crenolanib inhibited the phosphorylation of wild type PDGFRα at an IC50 of 10 nM. Additionally, crenolanib completely blocked PDGFRα phosphorylation and downstream AKT signaling at a concentration between 0.1 and 1 uM in Ink4a/Arf-/- mouse astrocytes transfected to stably co-express both human PDGFRα and PDGF AA. The lung cancer cell line H1703, which is reported to have amplification of both PDGFRA (4q12) and PDGFC (4q32) genes on chromosome 4, and also overexpress PDGFRα, was sensitive to crenolanib with an IC50 of ~80 nM. In CHO cells expressing an activating exon 18 (D842V) PDGFRα mutation, crenolanib was effective at an IC50 of 6nM and IC90 of 25nM.
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The clause demanding candidates to be born or stably reside in the province they represent wasn't added until the reform of 1860. De Ángelis's proposition of demanding candidates to practice a liberal profession or own lands was finally rejected. The mandate of the deputies was to last for four years, with the possibility of reelection; the renovation of the chamber would take place by halves each 2 years; a transitory disposition set a casting of lots to choose the deputies that would have to leave their seats after two years in the first cycle of elections; what had to be repeated in other moments of the Argentine history, when the national congress was repeatedly dissolved by military governments during the 20th century. The election of the deputies according to the constitution had to be done "by simple plurality of suffrages".
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In western and northern Awadh, for example, for much of the eighteenth century, the Muslim gentry offered the Kurmi highly discounted rental rates for clearing the jungle and cultivating it. Once the land had been brought stably under the plough, however, the land rent was usually raised to 30 to 80 per cent above the going rate. Although British revenue officials later ascribed the high rent to the prejudice among the elite rural castes against handling the plough, the main reason was the greater productivity of the Kurmi, whose success lay in superior manuring. According to historian Christopher Bayly, > Whereas the majority of cultivators manured only the lands immediately > around the village and used these lands for growing food grains, Kurmis > avoided using animal dung for fuel and manured the poorer lands farther from > the village (the manjha).
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Their full availability for the Prelature is lived out as full availability for doing a specific type of work, namely looking after the domestic needs of the conference centers and the residential centers of Opus Dei.Statutes of Opus Dei 2.8 and 2.9 Hence they live in special centers run by Opus Dei and do not have jobs outside the centers. Associates are celibate faithful who make themselves fully available to God and to others in apostolic celibacy, and stably take on at least one (sometimes more) apostolic assignment(s) from the Prelature in giving doctrinal and ascetical formation and/or coordinating activities.Statutes of Opus Dei 2.10 They differ from numeraries in not making themselves "fully" available to staff the official undertakings of the Prelature, instead giving themselves in additional social realities, such as through their profession or to their own families.
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However, for optimal ligation efficiency with cohesive-ended fragments ("sticky ends"), the optimal enzyme temperature needs to be balanced with the melting temperature Tm of the sticky ends being ligated, the homologous pairing of the sticky ends will not be stable because the high temperature disrupts hydrogen bonding. A ligation reaction is most efficient when the sticky ends are already stably annealed, and disruption of the annealing ends would therefore result in low ligation efficiency. The shorter the overhang, the lower the Tm. Since blunt-ended DNA fragments have no cohesive ends to anneal, the melting temperature is not a factor to consider within the normal temperature range of the ligation reaction. The limiting factor in blunt end ligation is not the activity of the ligase but rather the number of alignments between DNA fragment ends that occur.
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The water at the surface of Lake Ohrid moves predominantly in a counter-clockwise direction along the shore, as a result of wind forcing and the Earth rotation, similar to the Ekman-phenomenon known from oceans. In terms of vertical water exchange, convective mixing during winter cooling is the dominant process. However, in an average winter only the top 150–200 meters of the lake are mixed, whereas the water below is stably stratified by salinity. The stability due to this salinity gradient allows complete convective mixing events only roughly once every 7 years.S. D. Hadzisce, "The mixo-phenomenon of Lake Ohrid in the course of the years 1941/42-1964/65 (in German)" (Proceedings of the International Association of Theoretical and Applied Limnology 1966, 16: 134–138) Both in terms of nutrient concentration (4.5 μg L−1 of phosphorus), as well as biological parameters Lake Ohrid qualifies as oligotrophic.
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An intermediate frequency was first used in the superheterodyne radio receiver, invented by American scientist Major Edwin Armstrong in 1918, during World War I. A member of the Signal Corps, Armstrong was building radio direction finding equipment to track German military signals at the then-very high frequencies of 500 to 3500 kHz. The triode vacuum tube amplifiers of the day would not amplify stably above 500 kHz, however, it was easy to get them to oscillate above that frequency. Armstrong's solution was to set up an oscillator tube that would create a frequency near the incoming signal, and mix it with the incoming signal in a 'mixer' tube, creating a 'heterodyne' or signal at the lower difference frequency, where it could be amplified easily. For example, to pick up a signal at 1500 kHz the local oscillator would be tuned to 1450 kHz.
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A research study at University of Northern Carolina also reported that a housing project for the chronically homeless called Moore Place had saved the county $2.4 million. The implementation of Housing First philosophy when working with homeless families and young adults has been shown to increase clients' enrollment in public assistance benefits, decrease involvement in the child welfare system, and have very few returning to homelessness. When comparing the effects of Housing First on older and younger homeless adults, older homeless adults have shown significantly higher rates of improvement in areas like mental component summary scores, condition specific quality of life, mental health symptom severity, and percentage of days stably housed. When comparing the effects of Housing First on homeless adults with lower or borderline intellectual functioning to homeless adults with normal intellectual functioning it has been shown that there is no significant difference.
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Usually stainless steel will be used for the inner wall while outer wall can be stainless steel, plastic, or even embedded with other materials. Travel mug Mugs designed for use when driving are called auto mugs or commuter mugs. Travel mugs have a spill-proof lid with a sipping opening and in many cases, a narrower base, so that they will fit into the cup-holders that are built into many vehicles. Additional criteria for evaluating auto mugs include: they must be easy to open single-handedly (to prevent distractions while driving), include a fill line (to prevent over-filling, which contributes to leaking), preferably have no handles (no-handled mugs are easier to grab while driving), should not obstruct a driver's view of the road when he or she is drinking, and - with regard to cup-holders be able to fit, stably, into a wide range of mug holders.
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In Europe this problem was often overcome by dividing the drive between inside and outside cylinders, or else by using Articulated locomotives, although at the time it was not believed possible to run one stably at greater than . American railroads proved to be unwilling to use locomotives with inside cylinders, so the problem of balance could not be solved by adding more cylinders per coupled wheel set. As locomotives got larger and more powerful, their reciprocating machinery had to get stronger and thus heavier, and thus the problems posed by imbalance and hammer blow became more severe. Speed also played a factor, since the forces became greater and more destructive at higher wheel speeds. Ralph P. Johnson thought that the growing size and piston thrusts of existing express passenger locomotives could not be sustained with the by-then conventional 4-8-4 2-cylinder layout.
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The itinerant companies (or "of the league"), who carried the theatre in improvised open-air stages by the regions that did not have fixed locals, required a viceregal license to work, whose price or pinción was destined to alms and works pious. For companies that worked stably in the capitals and major cities, one of their main sources of income was participation in the festivities of the Corpus Christi, which provided them with not only economic benefits, but also recognition and social prestige. The representations in the viceregal palace and the mansions of the aristocracy, where they represented both the comedies of their repertoire and special productions with great lighting effects, scenery and stage, were also an important source of well-paid and prestigious work. Born in the Viceroyalty of New SpainAccording to the playwright's own statements, he was born in Mexico City in 1580 or 1581.
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Beginning in 1915, TFQ has been a prominent business serving the Shenandoah Valley, both commercially and philanthropically. Frazier Quarry is one of the largest family owned and operated quarries operating in the United States. The quarry was founded to function as a cornerstone to the region by providing crushed stone for new construction projects and helping to expedite the growth of the Shenandoah Valley. The crushed stone production from TFQ has remained a reliable mainstay in construction projects in the area, and through years of improving practices and setting systems in place, the crushed stone production is operating stably and the quarry has begun other initiatives to supply the Valley with high grade stone products. The most notable new direction is the production of “The Valley’s Own Bluestone” which has helped to resurrect the region’s architectural legacy of Bluestone construction by once again providing it from a local source.
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Pope Benedict released an explanatory letter at the same time. The document superseded the letter Quattuor Abhinc Annos of 1984 and the motu proprio Ecclesia Dei of 1988, which had allowed individual bishops, under certain conditions, to establish places where Mass could be said using the 1962 Missal. _Summorum Pontificum_ , Article 1 It granted greater freedom for priests to use the Tridentine liturgy in its 1962 form, stating that all priests of the Latin rite Church may freely celebrate Mass with the 1962 Missal privately. It also provided that "in parishes where a group of the faithful attached to the previous liturgical tradition stably exists, the parish priest should willingly accede to their requests to celebrate Holy Mass according to the rite of the 1962 Roman Missal" and should "ensure that the good of these members of the faithful is harmonised with the ordinary pastoral care of the parish, under the governance of the bishop" (Article 5).
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Regarding public Masses, the Pope asked parish priests and rectors of churches to permit, at the request of a group of the faithful attached to the previous liturgical tradition stably existing in the parish, celebration of a Tridentine Mass on weekdays, but also oneThe English translation omits the limitation on Sundays and feast days to a single such Mass. This limitation is expressed in the Latin text, which is what has juridical value. such Mass on Sundays and feasts, by a priest who is qualified and who is not excluded by law, and to grant permission also if requested "in special circumstances such as marriages, funerals or occasional celebrations, e.g. pilgrimages".Article 5 Apart from celebration of Mass, Pope Benedict authorised parish priests to grant, "after careful consideration" and "if advantageous for the good of souls", permission to use the older ritual in the administration of Baptism, Marriage, Penance, and Anointing of the Sick.
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Associates are faithful of Opus Dei who make themselves fully available to God and to others in apostolic celibacy, and stably take on at least one (sometimes more) apostolic assignment(s) from the Prelature in giving doctrinal and ascetical formation and/or coordinating activities.Statutes of Opus Dei 2.10 They differ from numeraries in not making themselves "fully" available to staff the official undertakings of the Prelature, instead giving themselves in additional social realities, such as through their profession or to their own families. Because of this difference in availability for the official activities of Opus Dei, unlike numeraries the associates do not live in Opus Dei centers but maintain their own abodes. Some of their family life (emotional and social support) comes from the centers of Opus Dei, some from other associates of Opus Dei, and some from their personal families and friends; the precise ratio of this distribution depends upon the circumstances of the individual associate.
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Earnshaw's theorem does not allow for a static configuration of permanent magnets to stably levitate another permanent magnet or materials that are paramagnetic or ferromagnetic against gravity. This theorem does not apply to devices consisting of a properly configured magnetic base and corresponding magnetic top, however, because the non-static nature of the spinning top acts as a gyroscope to prevent its toroidal magnetic field from fully aligning itself in the same direction as that of the supporting opposing field of the magnetic base (i.e.: via the top flipping). This gyroscopic property combined with the top's precession allows it to respond dynamically to the direction of the local toroidally shaped field of its base magnet and remain levitating about a central point in space above the base where the forces acting on the top (gravitational, magnetic, and gyroscopic) are in equilibrium thereby allowing the top to rest in an energy minimum well.
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549, no. 7672, June 2017, pp. 404–408., doi:10.1038/nature23880. Rather than daughter cells starting with no key signaling proteins after division, mitogen/ERK induced Cyclin D1 mRNA and DNA damage induced p53 protein, both long lived factors in cells, can be stably inherited from mother cells after cell division. The levels of these regulators vary from cell to cell after mitosis and stoichiometry between them strongly influences cell cycle commitment though activation of Cdk2. Chemical perturbations using inhibitors of ERK signaling or inducers p53 signaling in mother cells suggest daughter cells with high levels of p53 protein and low levels of Cyclin D1 transcripts were shown to primarily enter G0 whereas cells with high Cyclin D1 and low levels of p53 are most likely to reenter the cell cycle. These results illustrate a form of encoded molecular memory though the history of mitogen signaling through ERK and stress response though p53.
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" Art. 5 §1 of the papal document cited says: "In parishes where a group of the faithful attached to the previous liturgical tradition stably exists, the parish priest should willingly accede to their requests to celebrate Holy Mass according to the rite of the 1962 Roman Missal. He should ensure that the good of these members of the faithful is harmonized with the ordinary pastoral care of the parish, under the governance of the bishop in accordance with Canon 392, avoiding discord and favouring the unity of the whole Church." Article 2, to which Malloy said due regard was to be given, concerns Masses said without a congregation: "In Masses celebrated without a congregation, any Catholic priest of the Latin rite, whether secular or regular, may use either the Roman Missal published in 1962 by Blessed Pope John XXIII or the Roman Missal promulgated in 1970 by Pope Paul VI, and may do so on any day, with the exception of the Easter Triduum.
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However, in contrast to their role as a source of mortality and population control, viruses have also been postulated to enhance survival of prokaryotes in extreme environments, acting as reservoirs of genetic information. The interactions of the virosphere with microorganisms under environmental stresses is therefore thought to aide microorganism survival through dispersal of host genes through Horizontal Gene Transfer. > Each second, “there's roughly Avogadro’s number of infections going on in > the ocean, and every one of those interactions can result in the transfer of > genetic information between virus and host” — Curtis Suttle Temperate phages (those not causing immediate lysis) can sometimes confer phenotypes that improve fitness in prokaryotes [7] The lysogenic life-cycle can persist stably for thousands of generations of infected bacteria and the viruses can alter the host's phenotype by enabling genes (a process known as lysogenic conversion) which can therefore allow hosts to cope with different environments. Benefits to the host population can also be conferred by expression of phage-encoded fitness-enhancing phenotypes.
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Portrait of Mehmet II by Gentile Bellini, c. 1481, 69.9x52.1 cm, National Gallery, London, originally in the Layard Gallery in Ca Cappello Ca Cappello was purchased, at a date given variously as 1874 and 1878 by sources, by the English archeologist, diplomat and politician Austen Henry Layard, with the help of the doyen of the British community in Venice, the historian Rawdon Brown.Hutton, L. Literary Landmarks of Venice, New York, 1896, pp.39-40 Layard, who had shipped his great collection of Italian Renaissance paintings to Venice in 1875, inhabited the palazzo stably following his withdrawal from the diplomatic career after political debacle in Istanbul and deep disagreement with Gladstone until his death by cancer, on the occasion of a rare visit to London, in 1894.Mamoli-Zorzi, R. Enid e Henry Austen Layard: collezionismo e mondanità a Palazzo Cappello in Bisutti, F. & Celotti, M. Personaggi stravaganti a Venezia tra '800 e '900: Le storie del FAI/1, Venezia, 2010, pp.
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The maintenance of heterochromatin regions by RITS complexes has been described as a self-reinforcing feedback loop, in which RITS complexes stably bind the methylated histones of a heterochromatin region using the Chp1 protein and induce co-transcriptional degradation of any nascent messenger RNA (mRNA) transcripts, which are then used as RNA-dependent RNA polymerase substrates to replenish the complement of siRNA molecules to form more RITS complexes. The RITS complex localizes to heterochromatic regions through the base pairing of the nascent heterochromatic transcripts as well as through the Chp chromodomain which recognizes methylated histones found in heterochromatin. Once incorporated into the heterochromatin, the RITS complex is also known to play a role in the recruitment of other RNAi complexes as well as other chromatin modifying enzymes to specific genomic regions. Heterochromatin formation, but possibly not maintenance, is dependent on the ribonuclease protein dicer, which is used to generate the initial complement of siRNAs.
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To make it a reality, the focus was on creating a Dynamic Single Mode laser (DSM laser) (Fig.2) which has the following three characteristics: (1) operates at a wavelength band which causes minimal loss within the optical fiber to allow for long-distance transmission (1.5 micrometers was discovered to be the ideal wavelength band during the course of following research); (2) operates stably at a single wavelength to surmount the problem of transmission capacity reduction due to dispersion on the propagation constant in single mode optical fiber; and (3) allows the wavelength to be tuned to adapt to communication in multiple wavelengths. First, in 1972–1974, Suematsu and his student proposed a single mode resonator which would consist of refractive index waveguide for the transverse mode, and two distributed reflectors joined together with a phase shift by odd numbers of a half π for the axial single mode operation (Fig.2) .
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Kreck grew up as the son of the theologian Walter Kreck in Herborn and studied mathematics and physics from 1966 to 1970, and business administration at the Universities of Bonn, Berlin and Regensburg. In 1970 he submitted his diploma in Mathematics in Bonn and in 1972 he received his doctorate there under the supervision of Friedrich Hirzebruch, with a thesis titled An invariant for stably parallelized manifolds. From 1972 to 1976 he studied Protestant theology in Bonn: in a similar period he was also assistant from 1970 to 1976 to professor Hirzebruch. In 1977 he completed his habilitation in Bonn in Mathematics, titled Bordism groups of diffeomorphisms. In 1976 he became professor at the University of Wuppertal and in 1978 he moved to the University of Mainz. From 1994 to 2002 he was director of the Mathematical Research Institute of Oberwolfach. In 1999 he became professor at the University of Heidelberg. From 2007 until October 2011 he was the founding director of the Hausdorff Research Institute for Mathematics at the University of Bonn.
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His most seminal research accomplishments include the direct visualization in living cells of the recruitment of factors involved in gene expression to active genes; the development of a biochemical fractionation approach to purify a sub-nuclear domain (nuclear speckles) and characterize its protein constituents; the development of a live cell imaging system to visualize a stably integrated genetic locus and follow in real-time its mRNA and protein products; the elucidation of a rapid-response mechanism of regulating gene expression through RNA nuclear retention; identification of a mechanism by which a single genetic locus can produce a long nuclear retained non-coding RNA and a small cytoplasmic tRNA-like transcript, the identification and characterization of a long nuclear retained non-coding RNA that is involved in organizing a sub- nuclear organelle (paraspeckles), and determining that knockout or knockdown of the lncRNA Malat1 results in the differentiation of mammary tumors and a significant reduction in metastasis. In addition, Spector has co-edited numerous microscopy techniques manuals (i.e. Basic Methods in Microscopy, Live Cell Imaging: A Laboratory Manual), and a treatise of The Nucleus, that are used in laboratories throughout the world.
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