Oliver Smithies was born on June 23, 1925, in Halifax, England.
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Dr. Smithies found a bottle of starch in a chemical storeroom.
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Oliver Smithies would have made that veteran feel better too, I think.
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But when Dr. Smithies ran the experiment, the insulin stuck to the paper.
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Smithies could not resist "picking up anything" to experiment with, a habit his colleagues noticed.
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Dr. Smithies returned to the University of Wisconsin in 1960, joining its genetics research group.
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Each bar was a gene, and the 11th bar was the gene Dr. Smithies had altered.
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Smithies was a Nobel laureate scientist whom I interviewed in 2016, shortly before he died at 91.
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Dr. Smithies spent three years trying to insert bits of genetic material into cells to correct the gene.
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If Dr. Reed shunned a medical tool, Oliver Smithies, one of many groundbreaking scientists to die this year, created one.
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Over the next few months, Dr. Smithies worked at improving his method, using it to separate cabbage enzymes and, eventually, the proteins in blood plasma.
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His lab chief, an expert on insulin, told Dr. Smithies that he could do whatever he wanted, as long as it was related to insulin.
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"We've been listening to a range of views around what we should consider relevant to the current 'fit and proper test,'" said Joe Smithies, a spokesman for Ofcom.
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Dr. Smithies shared the 2007 Nobel Prize in Physiology or Medicine with Mario R. Capecchi of the University of Utah and Sir Martin J. Evans of Cardiff University in Wales.
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In addition to gene targeting, Dr. Smithies invented a method of separating proteins with a jelly made from ordinary potato starch, a major advance that was cheaper, easier and more precise than existing technologies.
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Then Dr. Smithies and Dr. Capecchi each showed that genetic changes made in one kind of cell, an embryonic stem cell, could be passed on, a discovery that enabled scientists to breed mice with specific disease conditions.
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Oliver Smithies, a British-born biochemist and inveterate tinkerer who shared a Nobel Prize for discovering a powerful tool for identifying the roles of individual genes in health and disease, died on Tuesday in Chapel Hill, N.C. He was 91.
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A guard of honor was formed by uniformed RSPCA officers at her funeral.Catherine Smithies' memorial Wood Green After her death, Smithies was memorialised by Thomas, in issue number 281 of The British Workman. Smithies' family and friends erected an obelisk and public drinking fountain in Wood Green, London as a memorial.
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In 1812, she married James Smithies at St Peter's Church, Leeds. Her son, Thomas Bywater Smithies, the second of ten children, was born in 1817. After her husband's death, she moved to London to live with Thomas at Earlham Grove House. In the 1860s, Smithies authored A Mother's Lessons on Kindness to Animals, which was published in several volumes.
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For the Rugby League footballer see Robert Smithies Robert Smithies (4 April 1934 – 31 July 2006) was a British photographer, journalist and crossword compiler. He was born in Middleton, near Rochdale, Lancashire. Smithies began his career from school at the Manchester Evening News as a darkroom assistant, progressing to the post of photographer there and later at the Manchester Guardian. Smithies joined Granada Television in the mid-1970s and presented a number of television programmes between then and 2005, including Down To Earth.
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The incumbent was Jan Smithies who stepped down at this election.
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From 1992, John J. Smithies was Director of the State Film Centre of Victoria, until its merger with Film Victoria in 1997 formed Cinemedia.Making Culture Count John Smithies. Retrieved 28 February 2015. At Cinemedia, Smithies was Deputy Director, with prime responsibility for developing the Australian Centre for the Moving Image. He became the first director and CEO of ACMI in March 2002.
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Thompson coached football for the old Tech High School 'Smithies' in Atlanta.
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Smithies 2002, p.46 and King Narai himself died in detention on July 10–11, with his death possibly hastened by poisoning. Phra Phetracha was crowned king on August 1.Smithies 2002, p.184 Kosa Pan, the 1686 former ambassador to France, and a strong supporter of Phetracha, became his Minister of Foreign Affairs and Trade.Desfarges, in Smithies 2002, p.35 Princess Krommaluang Yothathep ultimately had to marry Phetracha and become his queen.
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The Chameleons were formed in Middleton, Greater Manchester, England in 1981 by Mark Burgess, Reg Smithies and Dave Fielding. Burgess previously played with the Cliches, while Smithies and Fielding had performed with Years. They started as a trio—Burgess as vocalist and bassist, Smithies and Fielding both on guitar—without a drummer. They later recruited fellow Middletonian Brian Schofield, who was soon replaced by Dukinfield-based John Lever, previously of the Politicians.
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After 10 penalties each, the sides were still inseparable, and Smithies and opposite number Steve Simonsen stepped up to take the next penalties for their sides. Smithies scored in emphatic fashion, before Simonsen put his penalty over the bar to give promotion to the terriers.
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Smithies QPR's first choice goalkeeper for the 2016–17 season. He was in inspired form making 46 appearances and keeping 7 clean sheets. Smithies won the QPR player's player of the season, supporters' player of the season and the Junior Hoops players of the season.
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Smithies, p.93 The French had two fortresses (one in Bangkok, one in Thonburi on the other side of the Chao Phraya river) and 200 men, including officers. General Desfarges was commander-in-chief, and Mr de Vertesalle was second in command.Desfarges, in Smithies 2002, p.
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Smithies was initially the backup goalkeeper to Rob Green. Due to a clause in his contract, Green did not play from 1 January 2016 to the end of the season. Smithies and Matt Ingram vied for the number 1 spot. He played 18 Championship matches that season.
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Smithies 2002, p.185 Tachard travelled a fifth time to Asia and died in Chandernagor in 1712.
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Smithies is a placename, the plural form of a Smithy industry, and also a relatively rare surname.
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On 17 November 2009 Smithies was linked with Stoke City after a scout from the club was the latest in a long string of Premier League interest to be seen at the Galpharm. This interest was played down by Lee Clark and Tony Coton, and Smithies insisted he was happy to be at Huddersfield. Smithies was named as the Football League Young Player of the Month for February 2010 after keeping three clean sheets in seven undefeated Huddersfield Town matches.
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Making Culture Count John Smithies. Retrieved 28 February 2015.ACMI Report of Operations, 2002. Retrieved 28 February 2015.
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Smithies was transferred to Van Diemen's Land (Tasmania) in 1855 and remained there until his death in 1872.
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On 20 August 2015, Smithies joined Queens Park Rangers for an undisclosed fee, signing a three-year deal.
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Smithies, Tom (19 June 2013). Was Josh Kennedy the Socceroos' saving grace? The Daily Telegraph. Retrieved 2015-01-31.
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Ahead of the 2020–21 season, with Smithies considered the starting goalkeeper, Cardiff made Etheridge available for a possible transfer.
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Vollant des Verquains, in Smithies 2002, p.70 The Chao Praya, connecting the fortress of Bangkok to the sea, was lined with numerous forts, and was blocked at its mouth with five to six rows of huge tree trunks, an iron chain and numerous embarkations.Desfarges, in Smithies 2002, p.52 Altogether, there were seven batteries, containing 180 cannons.Vollant des Verquains, in Smithies 2002, p.140 Since two ships of the king of Siam were out at sea being commanded by some of his officers, Desfarges sent a longboat to try to reach them, and possibly call the French in India (Pondicherry) for help.De la Touche, in Smithies 2002, p.71 The longboat was commanded by a company lieutenant and ship ensign, Sieur de Saint-Christ.
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The Four Poster was produced at The White Hart Inn in Salisbury and the Smithies saw the article in the tristate paper, Litchfield Times, about the building and Kimberly Gelvin-Melville's desire to save it. She gave the Smithies permission to purchase it because they liked all of her ideas to turn it back into a theater and run shops downstairs to help finance it. In 1998, the building was purchased by playwrights and theater producers Maura Cavanaugh and Richard Smithies for US$50,000, who undertook a US$650,000 restoration that included the rebuilding of an observation tower that was part of the original structure. Cavanaugh and Smithies renamed the venue the Greenwoods Theater and brought dramatic and musical productions to its stage.
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Smithies with Huddersfield Town after the 2012 League One play-off Final Having come through the Academy of the club he grew up supporting, Smithies made his first-team debut on 5 December 2007. He came on as a 76th-minute substitute for the red-carded Matt Glennon during Huddersfield Town's 4–1 defeat by Southend United at Roots Hall. His first full start came in the 4–0 defeat at Leeds United on 8 December, after Glennon lost an appeal against his dismissal and Town were refused permission to loan an emergency goalkeeper on the grounds that Smithies was registered as a professional. Smithies' first appearance at the Galpharm Stadium for a first- team match was on 6 December 2008.
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The production of transgenic mice using this proposed approach was accomplished in the laboratories of Oliver Smithies, and of Mario Capecchi.
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Cradle Mountain has four named summits. In order of height they are Cradle Mountain (); Smithies Peak; Weindorfers Tower (); and Little Horn ().
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Smithies 2002, p.18 Phaulkon, who had been submitted to many tortures since his arrest, was beheaded by Phetracha's own son, Ok-Phra Sorasak.Vollant de Verquains, in Smithies 2002, p.134 Desfarges returned to Bangkok on 6 June accompanied by two mandarins, including Kosa Pan, the former ambassador to France, to whom he was supposed to remit the fortress.
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Phetracha moved to besiege the French fortress in Bangkok with 40,000 men,De la Touche, in Smithies 2002, p.66 and over a hundred cannons.De la Touche, in Smithies 2002, p.70 The Siamese troops apparently received Dutch support in their fight against the French, and the Dutch factor Johan Keyts was accused of collaborating with the Siamese.
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John Geoffrey Smithies (born 1954) is an Australian artist and arts manager. He is a sculptor and installation artistAustralian Art Auction Records John Geoffrey Smithies (1954-.) Australia. Retrieved 3 March 2015. who has been director of the State Film Centre of Victoria, but is best known as the founding director of the Australian Centre for the Moving Image.
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Smithies married Lois Kitze, a virologist at the University of Wisconsin, in the 1950s; they separated in 1978. His second wife, Nobuyo Maeda, is a pathology professor at the University of North Carolina. Smithies was a naturalized American citizen, and, despite being color-blind, was a licensed private airplane pilot who enjoyed gliding. He described himself as an atheist.
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Alexander Smithies (born 5 March 1990) is an English professional footballer who plays as a goalkeeper for club Cardiff City. Smithies is a product of the Huddersfield Town academy who first came into prominence during the 2007–08 season. He joined Queens Park Rangers in 2015 where he played for three years before joining Cardiff City.
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Smithies previously played football for Westend Juniors in Huddersfield's local leagues, and he joined the Huddersfield Town academy at the age of 8.
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Earlham Grove, Wood Green, founder of the Band of Mercy movement Modelled after the Band of Hope of the temperance movement, the first Bands of Mercy were created in 1875, by the philanthropist Catherine Smithies in Britain. The movement had a periodical, Band of Mercy Advocate (1879–1934), which was originally edited by Smithies' son Thomas Bywater Smithies. In 1882, the Royal Society for the Prevention of Cruelty to Animals (RSPCA) assumed responsibility for organizing and promoting the Band of Mercy and its publications. The Band of Mercy movement soon spread to Australia, Canada and US.
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Smithies was born in Halifax, West Yorkshire, England, to William Smithies and his wife Doris, née Sykes. His father sold life insurance policies and his mother taught English at Halifax Technical College. He had a twin brother and a younger sister. He attended a primary school in the nearby village of Copley and then went to Heath Grammar School in Halifax.
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Smithies signed for newly promoted Premier League club Cardiff City on 28 June 2018 on a four-year contract for an undisclosed fee. He made his debut in a 3–1 League Cup loss to Norwich City on 28 August. Smithies made his league debut a year later, in a 2–1 win over Luton Town on 10 August 2019.
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Smithies, Note 3, p.28 Artus de Lionne then returned to Siam with the Siamese embassy in 1687 on board the ships of the French ambassador Simon de la Loubère. He played a role in the negotiation between the French and Siamese sides during the 1688 Siamese Revolution,Smithies, Note 51, p.34 which resulted in the expulsion of the French forces.
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The Reverend John Smithies (1802-1872) was a Wesleyan Methodist missionary who served in Newfoundland, the Swan River Colony of Western Australia, and Tasmania.
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Smithies was born in York, to James and Catherine Smithies, the second of ten children. His mother was a campaigner for abolitionism, animal welfare and temperance. He was converted to Methodism at age 15, joining the Methodist Society. The following year, he started work at the Yorkshire Fire and Life Insurance Company, where he worked for 18 years, while also working as a Sunday school teacher.
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On 20 July 1883, after a period of long illness, Smithies died of heart disease, aged 67. He was buried with his mother in Abney Park Cemetery.
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Morgan Smithies is a rugby league footballer who plays as a forward for the Wigan Warriors in the Super League and the England Knights at international level.
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Zhou Daguan, The Customs of Cambodia, transl. by Michael Smithies, Bangkok: The Siam Society, 2001.Zhou Daguan, Sitten in Kambodscha. Leben und Alltag in Angkor im 13.
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The Siamese troops also apparently received Dutch support in their fight against the French.De la Touche, in Smithies 2002, p. 66-71 On September 9, the French warship Oriflamme, carrying 200 troops and commanded by de l'Estrilles, arrived at the mouth of the Chao Phraya River, but was unable to dock at the Bangkok fortress as the entrance to the river was being blocked by the Siamese.Desfarges, in Smithies 2002, p.
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Smithies came to Balmain from the Illawarra competition in 1969. He played three seasons with Balmain between 1969–1971, before moving to England to play for Hull KR for five years making 54 appearances plus 1 substitute appearance, scoring 22 tries for 66 points. Smithies won a premiership with Balmain when he played full-back in the 1969 Grand Final.Alan Whiticker/Glen Hudson: Encyclopedia Of Rugby League Players.
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Smithies started his second season in the Championship how he started his first, by starting all Huddersfield's opening eleven fixtures in all competitions, conceding 10 goals during that time. On 25 September 2013, Smithies agreed a new one-year contract extension at the club, keeping him at the John Smith's Stadium at least until the summer of 2016, with the Club having the option for a further year to June 2017.
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Smithies 2002, p.185 Recalled to France, he left 108 troops in Pondicherry to bolster defenses, and left with his remaining troops on the Oriflamme and the Company ships Lonré and Saint-Nicholas on February 21, 1690.Smithies 2002, p.179 Desfarges died on his way back trying to reach Martinique, and the Oriflamme sank shortly thereafter on February 27, 1691, with most of the remaining French troops, off the coast of Britanny.
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Smithies was born in Tasmania in 1954. He studied at the Tasmanian School of Art, the South Australian School of Art, Monash University and the Academy of Fine Arts, Karlsruhe, Germany.
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Thomas Bywater Smithies (27 August 1817 — 20 July 1883) was an English radical publisher and campaigner for temperance and animal welfare. He was the founder and editor of The British Workman.
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However, when Leicester had a bid for Kasper Schmeichel accepted by Leeds United in June, speculation that Smithies could be heading for Leeds was rejected by Huddersfield chief executive Nigel Clibbens.
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While at the University of Wisconsin in the 1980s, Smithies developed gene targeting in mice, a method of replacing single mouse genes using homologous recombination. Mario Capecchi also developed the technique independently. This research is the basis of methods used worldwide to investigate the role of particular genes in a wide range of human diseases including cancer, cystic fibrosis and diabetes. In 2002, Smithies worked with his wife, Nobuyo Maeda, studying high blood pressure using genetically altered mice.
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Martin Wainwright and Hugh Stephenson, "Obituary: Bob Smithies", The Guardian, 3 August 2006. Accessed 16 February 2013. Since his first cryptic crossword was accepted by The Guardian newspaper in 1966, Smithies was a regular compiler for the newspaper, under the pseudonym Bunthorne, the name taken from the leading character in the Gilbert and Sullivan light opera Patience. As a crossword setter his clues became known for requiring potentially obscure general knowledge, ranging from Austen and Dickens to French cheeses.
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During the second leg League One play-off match against Milton Keynes Dons he came on as a substitute for Bennett, who had gone off with an injured hand. Town lost the match 2–1 but reached the final against Sheffield United 3–2 on aggregate. Smithies started in the final, which finished 0–0 thanks to some excellent saves from the young custodian. In the penalty shoot-out Smithies performed more heroics, saving three of the Sheffield penalties.
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In 1990 they founded Interactive Studios which later became Blitz Games Studios. In October 2013 they founded Radiant Worlds,Develop based in Leamington Spa, with long time friend and colleague Richard Smithies.
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Edited and translated by Michael Smithies. Borobudur, p. 47. Oxford University Press. . From this rough layout, new lines were drawn in the paving in order to expand and build the temple properly.
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Smithies was born in Huddersfield, West Yorkshire. He grew up in Golcar, in the Colne Valley area of Huddersfield. He attended Colne Valley High School, Linthwaite. He grew up supporting Huddersfield Town.
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The buildings are all used as dwellings, even the old smithies. In the woods is found the Rexroth family's old graveyard. Today, the Höllhammer is private property and not accessible to the public.
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Among the people with whom she has worked was the Nobel Prize winner, Oliver Smithies. In Bradford, she worked over the holidays with Prof. Karin Schallreuter on plastic surgery. While working with Prof.
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While a Preston player, he was selected to play at inside right for The Rest, to play against the England amateur team in an international trial. The Rest outplayed England, particularly in the forward play, winning 7–0. Smithies scored three and was involved in two others, a performance which secured his selection for the forthcoming international in which England's amateurs beat their Welsh counterparts 2–0. Smithies scored both goals, and was described as having "led the forwards with dash".
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The Smithies Peak, sometimes incorrectly called Smithies Towers, is a mountain in the Central Highlands region of Tasmania, Australia. The mountain is situated in the Cradle Mountain-Lake St Clair National Park. At above sea level, it is the ninth-highest mountain in Tasmania, and is one of the summits of Cradle Mountain. The peak is composed of dolerite columns, similar to many of the other mountains in the area and rises above the glacially formed Dove Lake (), Lake Wilks and Crater Lake.
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On 2 June, General Desfarges, commander of the Bangkok fortress, was invited to Lopburi by Phetracha, and according to the account of one of his officers named De la ToucheRelation of what occurred in the kingdom of Siam in 1688 by De la Touche, translated in Smithies, Michael (2002), Three military accounts of the 1688 "Revolution" in Siam received promises of significant personal gains, such as the naming of his eldest son, Marquis Desfarges, to a major position in the Siamese government, equivalent to that which Constantine Phaulkon had held.De la Touche, in Smithies 2002, p.68 Phetracha also required Desfarges to move his troops from Bangkok to Lopburi in order to contribute in an ongoing war with the Lao and the Cochin-Chinese.De la Touche, in Smithies 2002, p.
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Chou Ta-Kuan, The Customs of Cambodia, transl. by John Gilman d'Arcy Paul, Bangkok: Social Science Association Press, 1967.Zhou Daguan, The Customs of Cambodia, transl. by Michael Smithies, Bangkok: The Siam Society, 2001.
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1995 () Smithies played in Hull Kingston Rovers' 16–13 victory over Wakefield Trinity in the 1974 Yorkshire County Cup Final during the 1974–75 season at Headingley Rugby Stadium, Leeds on Saturday 26 October 1974.
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On discovering this, Smithies accused Wroth of planning to abduct his daughter, resulting in Wroth's transfer to Fremantle. The comptroller-general, probably realising no harm had been done, granted him a conditional pardon in 1853.
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The > old swords were unearthed, and pistols, they were cleaned off, and made > ready. In the smithies, the blacksmiths worked even on holidays. > Agricultural implements were beaten into pikes. Scythes were mounted on long > poles.
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In the pre-industrial age, numerous mills, smithies and foundries arose along the Volme, from which the iron industry developed during the 19th and the 20th centuries. The Hagen–Dieringhausen railway runs through the valley.
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In an effort to end the stalemate with the French in Bangkok, on 24 June Phetracha released the two sons of Desfarges, whom he had been holding as hostages since the visit of General Desfarges to Lopburi in early June, as well as all other French prisoners.Desfarges, in Smithies 2002, p.48 Although he tried to make peace with the French, Phetracha managed to eliminate all the viable candidates to the throne: the two brothers of the king were executed on 9 July 1688.Smithies 2002, p.
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After a period of turmoil, with the organisation over budget, Smithies resigned from the Victorian Public Service in 2004. He later said the facility had been forced to open while "under-funded" by the Victorian Government. In December 2005, Smithies joined the Cultural Development Network (CDN), an independent non-profit organisation that links individual practitioners, community organisations and government across Victoria, as Director. About the same time, he recommenced working as an artist (painting and sculpture) with an ongoing interest in digital media and interactive broadcasting.
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Smithies was born in Ribchester, Lancashire. He played for leading amateur team Northern Nomads while training to be a teacher, and maintained his amateur status throughout his football career. He played for Preston North End in the 1929–30 season, making his Football League debut in the Second Division on 2 November 1929 in a 4–1 win at home to Bradford Park Avenue. In 20 league games for the club, Smithies scored 10 goals, enough to make him Preston's joint leading scorer for the season.
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Frederick Albert Smithies (12 May 1929 – 24 September 2018) was a British trade unionist. Born in Lancashire, Smithies was educated at St Mary's College, Blackburn and St Mary's College, Twickenham, qualifying as a teacher. He taught in Accrington until 1960, then moved to Northampton, where he taught at St Mary's High School. He also joined the National Association of Schoolmasters and was elected to its National Executive in 1966, remaining on the body after a merger formed the National Association of Schoolmasters Union of Women Teachers (NASUWT).
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184Dhiravat na Prombejra, in Reid p.252 King Narai himself died on July 11, possibly with the help of poisoning.Vollant des Verquains, in Smithies 2002, p.145 Phetracha was crowned king on 1 August 1688, in Ayutthaya.
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Smithies became the first director and CEO of ACMI in March 2002. He was responsible for opening the new public facilities at Federation Square in Melbourne in October 2002.Cultural Development Network Staff. Retrieved 28 February 2015.
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The building contained two smithies. In the yard there was an oven below a shed without a chimney. Six men operated a double bellows to blaze the fire. The flames escaping through an opening in the roof.
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From 1992, John Smithies was Director of the State Film Centre of Victoria, until its merger with Film Victoria in 1997 formed Cinemedia. At Cinemedia, Smithies was Deputy Director, with prime responsibility for developing the Australian Centre for the Moving Image (ACMI). ACMI is the premier cinema-culture venue and exhibitor, and the first institution of its type in Australia. It houses exhibition spaces, state-of- the art cinemas, and media production spaces, and the combined access collection of the National Film and Sound Archive and the State film and media collection.
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In October 2013 they founded Radiant Worlds, based in Leamington Spa, UK, with long time friend and colleague Richard Smithies to develop SkySaga: Infinite Isles for Korean-based Smilegate. SkySaga was an ambitious online voxel based game based on an original concept by members of the Blitz Games Studios team. In August 2017 Smilegate put SkySaga on hold and the Olivers and Smithies put the company up for sale. In January 2018, Rebellion, a UK games developer and publisher purchased the company and renamed it to Rebellion (Warwick).
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In this match, caretaker manager Gerry Murphy dropped regular goalkeeper Matt Glennon in favour of the young custodian, who went on to help Huddersfield to a 2–1 victory over Walsall. The first clean sheet he kept for the club came on 13 December 2008. In the 1–0 win over Southend United, Smithies saved a penalty from James Walker, 10 minutes from time. Smithies became the first choice keeper for the remainder of the 2008–09 season and, after the arrival of manager Lee Clark, made the number one jersey his own.
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"Smithies, Frederick Albert", Who's Who In 1976, Smithies was elected as vice-president of NASUWT, then, later in the year, as the union's assistant general secretary. In 1981, he was promoted to deputy general secretary, and he was elected as general secretary in 1982, taking up the post early in 1983. While in post, he also served on the General Council of the Trades Union Congress and the executive of the International Federation of Free Teachers' Unions. He retired from the NASUWT in 1990, although he remained honorary treasurer of the international federation until 1993.
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In recognition of their discovery of how homologous recombination can be used to introduce genetic modifications in mice through embryonic stem cells, Mario Capecchi, Martin Evans and Oliver Smithies were awarded the 2007 Nobel Prize for Physiology or Medicine.
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George Herbert Smithies (22 November 1906 – 1980) was an English footballer who played as a centre forward in the Football League for Preston North End and Birmingham. He was capped several times for the England national amateur football team.
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Smithies 2002, p.100 who had been promised protection by being ennobled a countess of France, took refuge with the French troops in Bangkok, but Desfarges returned her to the Siamese under pressure from Phetracha on October 18.Smithies 2002, p.11/p.184 Despite the promises that had been made regarding her safety, she was condemned to perpetual slavery in the kitchens of Phetracha.Smithies 2002, p.51, note 101 Desfarges finally negotiated to return with his men to Pondicherry on November 13, on board the Oriflamme and two Siamese ships, the Siam and the Louvo, provided by Phetracha.De la Touche, in Smithies 2002, p.73 Some of the French troops remained in Pondicherry to bolster the French presence there, but most left for France on February 16, 1689 aboard the French Navy Normande and the French Company Coche, with the engineer Vollant des Verquains and the Jesuit Le Blanc aboard.
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Oliver Smithies (second on the left) Smithies was awarded a Commonwealth Fund fellowship to take up a post-doctoral position in the United States, in the laboratory of J. W. Williams at the University of Wisconsin–Madison's Department of Chemistry. A problem with acquiring a U.S. visa, due to a condition of the Commonwealth Fund fellowship, then forced him to leave the U.S. From 1953 to 1960, he worked as an associate research faculty member, under insulin researcher David A. Scott, in the Connaught Medical Research Laboratory at the University of Toronto in Canada. He learned medical genetics from Norma Ford Walker at the Hospital for Sick Children in Toronto. In 1960, Smithies returned to the University of Wisconsin–Madison, where he worked in the Department of Genetics until 1988 as, successively, assistant, associate and Leon J. Cole and Hilldale Professor of Genetics and Medical Genetics.
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Having previously played Victory Shield football for England at under-16 level, Woods made his debut for the England under-18 side on 20 November 2007 as a substitute for Alex Smithies during a 2–0 friendly win over Ghana.
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Mario R. Capecchi, Martin J. Evans and Oliver Smithies were awarded the 2007 Nobel Prize in Physiology or Medicine for their work on "principles for introducing specific gene modifications in mice by the use of embryonic stem cells", or gene targeting.
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Their low clearance hindered electrification efforts for over a century to come. The vast railroad infrastructure included housing facilities, water towers, smithies, and miscellaneous shops. Station houses — architectural masterpieces built in the typical early-20th-century Russian industrial style — had electricity.
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He was assigned to Western Australia in 1839 and, aboard the Prima Donna, landed near Fremantle on 22 June 1840 with his wife and four children, one of whom had been born at sea two weeks earlier. He was immediately introduced to an established fellow missionary, Francis Armstrong. Smithies' double mandate was "the pastoral care of colonists and the Christianization of the Aborigines". Smithies established a mission near what is now Wanneroo in July 1840. The "Perth Native School" was announced with an advertisement in the Inquirer on 18 August 1841, including the Board of Management and the Rules and Regulations.
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This led to a major dispatch of French ambassadors and troops to Siam in 1687,Smithies 2002, p.10 organized by the Marquis de Seignelay. The embassy consisted of a French expeditionary force of 1,361 soldiers, missionaries, envoys and crews aboard five warships.
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Pioneer Aboriginal Mission: The Work of Wesleyan Missionary John Smithies in the Swan River Colony 1840-1855, University of Western Australia Press, 1981. . In 1837, following sectarian tensions on the island, he returned to England for two years, including 12 months in Derbyshire.
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Catherine Smithies (; 1785 – 1877) was an English philanthropist and campaigner for animal welfare, abolitionism and temperance. She was the creator of the first Band of Mercy, which promoted teaching children kindness towards non-human animals and led to the Bands of Mercy movement.
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Smithies (2002), p. 35Smithies (1999), p. 2 Pan was met in Siam in 1690 by the German naturalist Engelbert Kaempfer. The naturalist noted "pictures of the Royal family of France and European maps" hanging "in the hall of his [Pan's] house":Suarez, p.
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Karen Smithies (born 20 March 1969) is a former England cricketer who played 15 women's Test matches and 69 women's one-day internationals and including the 1993 Women's Cricket World Cup triumph in England. She was born in Ashby- de-la-Zouch, Leicestershire.
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Frank Smithies FRSE (1912–2002) was a British mathematician who worked on integral equations, functional analysis, and the history of mathematics. He was elected as a fellow of the Royal Society of Edinburgh in 1961. He was an alumnus and an academic of Cambridge University.
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Trouser Press called it "a very solid LP, if no challenge to the Chameleons' general brilliance (inventive guitarists Dave Fielding and Reg Smithies are greatly missed)", while AllMusic described it as "an intelligent, gripping concept album that easily outshines [The Chameleons'] body of work".
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The purpose of the mission was to train aboriginal children in farm work.Collins, Doris, The Establishment of Methodism in York, Balaardong, No 3, 2002, The York Society. On 13 November 1850, Smithies and his wife visited Eliza Brown, wife of Thomas Brown, at Grass Dale near York, and in one of her letters to her father, she said of Smithies: "S sat fast asleep in his chair nearly all the time of this polite visit." Peter Cowan editor, A Faithful Picture, the letters of Eliza and Thomas Brown at York in the Swan River Colony 1841-1852, Fremantle Arts Centre Press, 1977, p.126.
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For their development of this technique, Mario Capecchi, Martin Evans and Oliver Smithies were awarded the 2007 Nobel Prize for Physiology or Medicine; Capecchi and Smithies independently discovered applications to mouse embryonic stem cells, however the highly conserved mechanisms underlying the DSB repair model, including uniform homologous integration of transformed DNA (gene therapy), were first shown in plasmid experiments by Orr-Weaver, Szostack and Rothstein. Researching the plasmid-induced DSB, using γ-irradiation in the 1970s-1980s, led to later experiments using endonucleases (e.g. I-SceI) to cut chromosomes for genetic engineering of mammalian cells, where nonhomologous recombination is more frequent than in yeast.
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He has four caps for the England U-16's and 10 caps for the England U-17's including five during the 2007 FIFA U-17 World Cup in South Korea. In this competition he helped England U-17's make it to the Quarter-finals, before they were eventually eliminated by Germany after a 4–1 defeat. On 20 November 2007, Smithies made his debut for the England U-18 team, where he played 45 minutes in their 2–0 win against Ghana U-18's at Gillingham's Priestfield Stadium. In November 2008, Smithies received his first England U-19 call up for a friendly against Germany U-19.
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Maeda's early work on sea snake venoms led to an interest in molecular evolution, which she pursued in Fitch's laboratory. She published in the 1980s on molecular evolution in higher primates such as chimpanzees and humans. Her work focused on the large mutational effects of recombination between members of multigene families, particularly in the human haptoglobin gene cluster. In 1987, Maeda, Smithies and coworkers used the novel technique of gene targeting – a method of replacing single mouse genes using homologous recombination developed by Smithies, Mario Capecchi and others – to correct the hypoxanthine-guanine phosphoribosyltransferase gene responsible for Lesch–Nyhan syndrome in mouse cells in vitro.
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John Smithies wrote in the following terms to the Wesleyan Missionary Society in London: > If any of your friends are thinking of Austral-Ind as a point of emigration > tell them to Stop. It is one of the greatest puffs that there has been for > some time.
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Smaller and less occurring carvings by the windows represent female figures. One exceptional example is carved on inner wall of the room depicting a representation of a Khmer prince which is identified by his crown.Dumarçay, Jacques (1978). edited and translated by Michael Smithies, "Borobudur", p. 47.
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On the terrain there were also three buildings where boilers were made. There were also other buildings for smithies, carpenters, painters, block makers etc. The total number of fires on the terrain was said to be 42, all in continuous operation. A big building was under construction.
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Some Captured History of Glanamman and Garnant The 1870-72 Imperial Gazetteer of England and Wales described Gwynfe chapelry as: The village previously had a number of services that are no longer present including 2 pubs, a school, 2 smithies, a corn mill and a woollen factory.
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Smithies 2002, p.19 On April 10, 1689, Desfarges - who had remained in Pondicherry - led an expedition to capture the tin-producing island of Phuket in an attempt to restore some sort of French control in Siam.Hall, p.350 The island was captured temporarily in 1689,Dhivarat na Prombejra, in Reid p.266 but the occupation led nowhere, and Desfarges returned to Pondicherry in January 1690.Smithies 2002, p.185 Recalled to France, he left 108 troops in Pondicherry to bolster defenses, and left with his remaining troops on the Oriflamme and the Company ships Lonré and Saint-Nicholas on February 21, 1690.Smithies 2002, p.179 Desfarges died on his way back trying to reach Martinique, and the Oriflamme later sank on February 27, 1691, with most of the remaining French troops, off the coast of Britanny.Smithies 2002, p.16/p.185 France was unable to stage any comeback or organize a retaliation due to its involvement in major European conflicts: the War of the League of Augsburg (1688–1697), and then the War of the Spanish Succession (1701-1713/1714).
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As of 1890 it consisted of 124 populated localities with total population 9209. As of 1908 in Zembin there were 1189 inhabitants. It a quarter greater than of today total population. There was a watermill, 4 smithies, a school,23 shops, a hospital 3 taverns and 5 inns.
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The mountain rises above the glacially formed Dove Lake (), Lake Wilks and Crater Lake. The mountain has four named summits. In order of height they are Cradle Mountain (), Smithies Peak (), Weindorfers Tower () and Little Horn (). The mountain itself is named after its resemblance to a gold-mining cradle.
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Gunn, p. 188 The embassy was bringing a proposal for an eternal alliance between France and Siam. It remained in France from June 1686 to March 1687. Kosa Pan was accompanied by two other Siamese ambassadors, Ok-luang Kanlaya Ratchamaitri and Ok-khun Si Wisan Wacha,Smithies 1999, p.
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Desfarges finally left with his men to Pondicherry on 13 November, on board the Oriflamme and two Siamese ships, the Siam and the Louvo, provided by Phetracha.De la Touche in Smithies 2002, p.73 Altogether, the siege had lasted more than four months, until the negotiated settlement was reached.Martin, p.
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There are several references to nailers in Shakerley. In 1846 the Shakerleys owned five nail smithies. James Astley was a nailor who died in 1681. There were nailers in Shakerley in between 1820 and 1840 but the rise of other industries meant nail making became extinct in Shakerley soon after.
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Cultural Development Network Staff. Retrieved 28 February 2015. After a period of turmoil, with the organisation over budget, Smithies left ACMI in 2004, and later said the facility had been forced to open while "under-funded" by the Victorian Government. Tony Sweeney was appointed director and CEO of ACMI in 2005.
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There were several mills, creameries, smithies, a tannery, senics, forest exchanges, three churches, twelve primary schools, and a gymnasium.Алфавитный список населенных мест Области войска Донского Приложение: Карта-справочник Области войска Донского. Новочеркасск. Областная войска Донского типография. 1915 In March 1920, during Russian Civil War, the village was taken by Red Army.
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Macfarren began to study music when he was fourteen, under Charles Lucas.Banister (1887–1888), 69. In 1829, at the age of sixteen, he entered the Royal Academy of Music, where he studied composition under Cipriani PotterSmither (2000), 339. as well as piano under William Henry Holmes and trombone with John Smithies.
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Bounds Green Road with the Catharine Smithies obelisk and drinking fountain in the background. Bounds Green Road (A109) is a road in the London Borough of Haringey that runs from the junction of Station Road and the North Circular Road in Bounds Green, to the High Road in Wood Green.
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During the reign of Ekathotsarot, a Siamese embassy reached the Dutch city of The Hague, in 1608.Smithies 2002, p.182 The embassy of 16 was brought to the Republic of the United Seven Provinces by Admiral Matelief on board the Oranje, leaving Bantam on January 28, 1608.Borschberg, ed.
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Smithies started his third season in the Championship as first choice goalkeeper, ahead of Joe Murphy. He conceded four goals on the opening day in a 4–0 home defeat to Bournemouth, but did save a penalty. The match would prove to be manager Mark Robins' last for the club.
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Initially known also as Woods Flat, the name of the village was changed to Woodstock in 1886.Kelton, 1987 By 1900 there were many commercial businesses in the villages including butchers, bakers, hotels, saddleries, smithies, bootmakers, mercers, tailors, motor vehicle garages and billiard rooms. A post office was operating by 1897.
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Ardsley, Athersley, Barugh Green, Darton, Carlton, Cudworth, Cundy Cross, Darfield, Dodworth, Elsecar, Gawber, Higham, Honeywell, Hoyland, Kendray, Kexbrough, Kingstone, Lundwood, Mapplewell, Monk Bretton, New Lodge, Oakwell, Old Town, Pogmoor, Royston, Shafton, Smithies, Staincross, Stairfoot, Wilthorpe, Woolley Colliery, Worsbrough (includes Worsbrough Bridge, Worsbrough Common, Worsbrough Dale, Worsbrough Village, and Ward Green), Wombwell.
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Women spun flax for linen. Sheep and cattle produced wool and milk, respectively, while oxen provided power for field labor. Water mills turned out grist and lumber, as well as seed for products such as linseed oil. Scattered throughout the area were several small stores, smithies, cider mills and other small businesses.
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Anthony Horneck Anthony Horneck (; 1641–1697) was a German Protestant clergyman and scholar who made his career in England. He became an influential evangelical figure in London from the later 1670s, in partnership with Richard Smithies, curate of St Giles Cripplegate.Martin Schmidt, John Wesley, A Theological Biography (1963), Volume I, p. 33.
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Clark gave Eastwood his full debut on the last day of the 2008–09 season, as regular keeper Alex Smithies had a shoulder injury. The match was Huddersfield's 1–1 draw against Leyton Orient at Brisbane Road on 2 May 2009. Eastwood was contracted to the club until the summer of 2011.
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Hector Pétard was itself a pseudonym, but not one originally coined by the Bourbaki members. The Pétard moniker was originated by Ralph P. Boas, Frank Smithies and other Princeton mathematicians who were aware of the Bourbaki project; inspired by them, the Princeton mathematicians published an article on the "mathematics of lion hunting". After meeting Boas and Smithies, Weil composed the wedding announcement which contained several mathematical puns. Bourbaki's internal newsletter La Tribu has sometimes been issued with humorous subtitles to describe a given conference, such as "The Extraordinary Congress of Old Fogies" (where anyone older than 30 was considered a fogy) or "The Congress of the Motorization of the Trotting Ass" (an expression used to describe the routine unfolding of a mathematical proof, or process).
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He attended high school with Alex Smithies, now the goalkeeper for Huddersfield Town Football Club. He then studied for 6 months at Huddersfield New College before deciding to move away from Huddersfield at the age of 17 so he may train at the National Badminton Centre in Milton Keynes. Ellis lived in St Albans.
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His first match for the U19's came against Spain U-19 at Bournemouth's Dean Court ground on 10 February 2009, in a 3–0 defeat. On 24 August 2010, Smithies received his first call-up to the England U-21's for their matches against Portugal U-21's and Lithuania U-21's.
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However, the score was 2–2 after the first five penalties, taking the shoot-out to sudden death. Each team scored their next five penalties, leaving goalkeeper Alex Smithies to be the last of the 11 Huddersfield players to take a penalty. He scored. Sheffield United's last penalty also fell to their goalkeeper Steve Simonsen.
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Nussey (date unknown) Ellen Nussey (20 April 1817 – 26 November 1897) was born in Birstall Smithies in the West Riding of Yorkshire, England. She was a lifelong friend and correspondent of writer Charlotte Brontë and, through more than 500 letters received from her, was a major influence for Elizabeth Gaskell's 1857 biography The Life of Charlotte Brontë.
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On the inside the great room had a large hearth in the middle and a raised wide bank alongside the outer walls for sleeping. Of the longhouses in Fyrkat at least two contained smithies and gold was worked with in two others. About a quarter of the excavated houses seem to have been warehouses of some sort.
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Smithies 2002, p.16/p.185 A Siamese-formed rebellion led by Thammathian broke out in 1690 against Phetracha's rule, but was suppressed. The governors of several regional provinces likewise refused to accept Phetracha's rule, and stood in rebellion until 1691. Phetracha's reign lasted until 1703, when he died and was succeeded by his eldest son Sanphet VIII.
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He became teetotal in 1837, aged 20. In 1849, Smithies moved to London to become the manager of the Gutta Percha Company. The first "Band of Hope" in London was formed at Hannah Bevan's house and it included some of her neighbours and children. In 1851, he published Sunday Scholars' Friend and the Band of Hope Review (1851–1937).
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This was followed by The British Workman in 1855; edited by Smithies. Subsequent publications included The Infant's Magazine, The Children's Friend, The Family Friend, The Friendly Visitor, and The Weekly Welcome. In 1879, he published the Band of Mercy Advocate (1879–1934), a periodical for the Bands of Mercy movement, which was founded by his mother.
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The coat-of-arms is from modern times; they were granted on 18 April 1986. The arms show three white or silver knives on a red background. The knife was chosen as a symbol for the smithies and knife makers in the municipality. Knife making has long been a local tradition for which the village is well known.
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On 17 August 2012, Smithies began his debut season in the Championship with Huddersfield in a 1–0 away defeat at eventual league winners Cardiff City. He went on to start all 46 of Huddersfield's Championship fixtures, as well as all but one of the club's five cup matches during the season, conceding 79 goals in the process.
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They collectively acquired almost half of the area, and profited from coal and ironstone mines and iron smithies on their estates. The area was also the site of the 1821 Cinderloo Uprising which saw 3,000 people protest the lowering of wages for those working in the local coal industry. The protests resulted in the deaths of three striking colliers.
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During the late Middle Ages Alvington parish and manor were under the ownership of Llanthony Priory (in Gloucester) which was dissolved in 1539. The lord of the manor's seat was situated in Clanna Falls around one mile from the village. In its history Alvington, has variously boasted two smithies, a small brewery, a small engineering works and several shops.
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Tom Hibbert of The Observer and Sandy Smithies of The Guardian both found the first episode fascinating.Hibbert, Tom, Preview The Observer, 17 January 1999 James Delingpole, Ludovic Kennedy and other critics found the documentary portentous and plodding.Letters, The Spectator, 13 February 1999 Robert Hanks of The Independent found the explanations were too brief to make the technicalities penetrable.
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Several constituent communities have kept their old timber-frame town halls, mostly from the 16th and 17th centuries. These are Elmshausen, Reichenbach and Gadernheim, whose old town hall now houses the local history museum. Gadernheim has also been home to a smithy since 1608, the Lauter valley's oldest building. Moreover, it is one of Hesse's oldest unchanged smithies.
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The military wing was led by General Desfarges, and the diplomatic mission by Simon de la Loubère and Claude Céberet du Boullay, a director of the French East India Company. Desfarges had instructions to negotiate the establishment of troops in Mergui and Bangkok (considered as "the key to the kingdom") rather than the southern Songkla, and to take these locations if necessary by force. King Narai agreed to the proposal, and a fortress was established in each of the two cities, which were commanded by French governors.Note 6, Smithies 2002, p.99Dhiravat na Prombejra, in Reid p.251-252 Desfarges noted in his account of the eventsAccount of the revolutions which occurred in Siam in the year 1688 by General Desfarges, translated by Smithies, Michael (2002) Three military accounts of the 1688 "Revolution" in Siam.
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Maeda first briefly worked in the laboratory of Nobuo Tamiya at the Department of Chemistry of Tohoku University. In 1978, she left Japan for the United States, and worked for a decade at the University of Wisconsin–Madison. She held post-doctoral positions in the laboratories of Walter M. Fitch (Department of Physiological Chemistry; 1978–81) and Oliver Smithies (Laboratory of Genetics; 1981–83), and then worked in the Laboratory of Genetics as an assistant and then associate scientist. She moved to the Department of Pathology of the University of North Carolina at Chapel Hill in 1988, with her collaborator (and later husband) Smithies, where she held successively positions as associate professor (1988) and professor (1996), and was appointed the Robert H. Wagner Distinguished Professor at the Department of Pathology and Laboratory Medicine in 2003.
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De la Touche, in Smithies 2002, p.76 He and his troops were stranded on a deserted island for four months before being captured by a British warship. They ultimately returned to Pondicherry by way of Madras. In the Siege of Bangkok, Phetracha besieged the French fortress in Bangkok with 40,000 men and over a hundred cannon, for a period of four months.
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Barbara Hyde Bowman (August 5, 1930May 15, 1996) was an American biologist, geneticist, and educator who was known for her research in human blood proteins. Her work characterized variants of globins, the family of proteins responsible for transporting blood in oxygen, and in 1984, Oliver Smithies and she showed that variations in haptoglobins were due to polymorphisms in the HP gene.
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A record eight teams participated, with Denmark, India, and the West Indies joining the five teams from the 1988 edition. Denmark and the West Indies were making their tournament debuts. England's Jan Brittin led the tournament in runs, while her captain Karen Smithies and New Zealand's Julie Harris led the tournament in wickets.Batting at Women's World Cup 1993 (ordered by runs) – CricketArchive.
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Only one woman, Barbara McClintock, has received an unshared prize in this category, for the discovery of genetic transposition. Mario Capecchi, Martin Evans, and Oliver Smithies was awarded the prize in 2007 for the discovery of a gene targeting procedure (a type of genetic recombination) for introducing homologous recombination in mice, employing embryonic stem cells through the development of the knockout mouse.
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Smithville High School is a public high school in Smithville, Ohio. It is the only high school in the Green Local Schools district. Their nickname is the Smithies, which was a nickname given to the school's teams by an early sports editor of the Wooster Daily Record. The colors of green and white came from the town's location within Green Township.
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Page Moss is an area in the borough of Knowsley, Merseyside. It borders the city of Liverpool to the east. Previously known as The Horn Smithies due to the junction of Stockbridge Lane and Liverpool Road appearing as a set of horns when heading in the direction of Prescot. The population of the Knowsley ward taken at the 2011 census was 7,076.
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Michael Smithies describes them as a "police force ... who were drilled like soldiers" and had responsibility for the maintenance of order among the 3-9,000 residents of the palace. The unit was to also brought into action during revolts if the regular Siamese army had failed to contain the threat. The unit accompanied the king on all occasions including hunting and riding.
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The Perkins chain was established in 1957, when Matt and Ivan Perkins opened what was called Smithies Pancake House in Cincinnati, Ohio. In 1958, the chain expanded as a franchise. One franchisee in Minnesota, Wyman Nelson, introduced an expanded menu and an aggressive advertising campaign in 1967. From 1969 to 1978, Nelson consolidated Perkins and another chain, Smitty's, into Perkins 'Cake & Steak'.
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Strauss married (as the first of his four wives) Seymour Papert. Papert was also South African, and became a co-author and fellow student of Frank Smithies with Strauss at Cambridge. She met her second husband, Edmond Strauss, at the University of London. She is a strong amateur chess player, and was director of the Brighton and Hove Progressive Synagogue for 2014–2015.
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The building, which was designed in the Italianate style, was built as a private residence for Thomas William Smith Oakes, an East India Company merchant; it was initially known as Earlham Grove House and was completed in 1865. The design involved a symmetrical main frontage with three bays facing onto High Road; the central section featured a doorway with fanlight flanked by paired Doric order columns on either side on the ground floor; there were single windows on each of the first and second floors above the doorway. The philanthropist Catherine Smithies, who founded the Band of Mercy animal welfare group which later merged with the RSPCA, lived in the house in the mid 19th-century. Her son, Thomas Bywater Smithies, who was the publisher of The British Workman, also lived in the house at that time.
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The relevance to the importance of the road is because of the salter's link.English Place Names, Kenneth Cameron, Book Club Associates, 3rd Edition, 1977, p.158 Just as the Doncaster Saltersbrook Road ran eventually to the Salter's Brook Bridge above Langsett, so too did the Salter's Lane through Cudworth. The lane ran across to Smithies, thus avoiding Barnsley and joined up to the Penistone Road.
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The Chameleons were an English post-punk band formed in Middleton, Greater Manchester in 1981. The band consisted of singer and bassist Mark Burgess, guitarists Reg Smithies and Dave Fielding, and drummer John Lever. They were called the Chameleons UK in North America because an American band had claim to "the Chameleons" name. The band released their debut album, Script of the Bridge, in 1983.
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They followed it with What Does Anything Mean? Basically and Strange Times in 1985 and 1986, respectively, before abruptly disbanding in 1987 due to the sudden death of the band's manager. After the split, Burgess and Lever formed the Sun and the Moon, while Fielding and Smithies formed the Reegs. Burgess also had a short solo career with backing band the Sons of God.
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After the breakup, numerous spin-off bands emerged, none of which achieved much success. Burgess and Lever formed the Sun and the Moon, recruiting Andy Whitaker and Andy Clegg to replace Smithies and Fielding. They released an eponymous studio album on Geffen in 1988, but separated the next year. Burgess then embarked on a solo career, while the remaining members briefly continued on as Weaveworld.
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Inquirer, 18 August 1841, p.6. By 1847, Smithies decided that York would be a better site for a Native Mission than Wanneroo. In 1851, an application was made to Governor Fitzgerald for 100 acres of good wheat land at York (some kilometres to the north on east side of the Avon River) “to be held for the improvement of the Natives for ever”.
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It has no stables, kennels, or smithies, but the towers can house 500 men, and the granary can sustain a small household for a year or more. The Eyrie does not keep livestock on hand; all dairy produce, meats, fruits, vegetables, etc., must be brought from the Vale below. Its cellars hold six great winches with long iron chains to draw supplies and occasionally guests from below.
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Vale comprises the whole of the Vale administrative division In the 2016 Guernsey general election there was a 3,774 or 74% turnout to elect six Deputies. Those elected (in order of votes received) being Matt Fallaize, Dave Jones, Mary Lowe, Laurie Queripel, Jeremy Smithies and Sarah Hansmann Rouxel. Dave Jones died in July 2016 and a by-election was held in October 2016 to elect a replacement.
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The hill fort Bojná I was protected by multiple walls as high as 6 meters with ditches and gates. In the 9th century, the hill fort was intensely populated. Several craft workshops (mostly smithies) and thousands of artifacts were unearthed on the place. Along with artisanal and agricultural tools, a large amount of weapons including typical battle axes, large knives, fragments of swords and seaxes.
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This was after he fell behind goalkeeper Alex Smithies in the pecking order. On 27 November 2008, he joined Conference Premier club Woking. His first appearance for Woking was in their 1–1 draw with Rushden & Diamonds on 9 December 2008. Following Huddersfield's 3–1 defeat by Crewe Alexandra on 21 February 2009, he was recalled by manager Lee Clark following an injury to Matt Glennon.
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37 For food, they also had about 100 cows, which Constance Phaulkon had had the foresight of providing them, which they started to slaughter. In order to facilitate defensive work, they also burnt down the small village which was near the Bangkok fortress.Desfarges, in Smithies, p.41 The first act of war was the attack on a Chinese junk belonging to the king of Siam, which was passing by.
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Smithies, p.8 During the 1688 Siamese revolution, Laneau and his missionaries were taken hostage by the Siamese, as guarantors for the execution of the retreat agreement negotiated between the French and the Siamese.Smithies, p.150 As the French failed to respect several elements of the agreement, Laneau and his missionaries were imprisoned by the resentful Siamese.Smithies, p.166-167 Laneau was not freed from the Siamese jails until April 1691.
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Bronze casting foundries existed at Porolissum, Romula, and Dierna; there was a brooch workshop located in Napoca, while weapon smithies have been identified in Apulum. Glass manufacturing factories have been uncovered in Ulpia Traiana Sarmizegetusa and Tibiscum. Villages and rural settlements continued to specialise in craftwork, including pottery, and sites such as Micăsasa could possess 26 kilns and hundreds of moulds for the manufacture of local terra sigillata.
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Capecchi won the Nobel prize for creating a knockout mouse. This is a mouse, created by genetic engineering and in vitro fertilization, in which a particular gene has been turned off.University of Utah, Transgenic Mice For this work, Capecchi won the 2007 Nobel prize for medicine or physiology, along with Martin Evans and Oliver Smithies, who also contributed. Capecchi has also pursued a systematic analysis of the mouse Hox gene family.
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On Our Street: Life in Athersley, New Lodge and Smithies, Roundhouse Community Partnership, 2006, p. 9 Factory built houses, or prefabs, comprise most of the estate. These are of the concrete section Tarran type, and the BISF houses, known as the 'tin houses'. By the late 1940s there was a thriving community of predominantly mining families and the estate was completed in the early 1950s with conventional brick houses.
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Former occupants include philanthropist Catherine Smithies (1785–1877), who founded the Bands of Mercy animal welfare group which later merged with the RSPCA. Wood Green local board of health purchased Earlham Grove House with 11 acres of land in 1893. The park was laid out and by 1914 boasted a bandstand (demolished at some point between 1957 and 1973). A pavilion was erected by the bowling green before 1935.
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Adelaide Lead in 1866 was a busy centre with many cottages and puddling machines, gardens, two smithies, dairies, several stores but no hotel. John Mintner was the blacksmith, while stores were operated by George Gellan and William Hall in partnership, Frederick Faulkner, William Blackey, William Pennock, John Dellar and Arthur Lindsay. Mr Henry Rudrum had a small holding with grapes and made wine in the 1860s and 70s.
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The nail smithies manufactured ploughs and scythes; their products were taken by pack horse to be sold in Manchester, Denbigh, Clitheroe and Kendal. The nail industry developed into the manufacture of nuts and bolts. Thomas Blakemore was the first in 1843 and by 1853 there were eight manufacturers of nuts and bolts including James Prestwich and Robert Parker. Some nut and bolt manufacturers also made spindles and flyers for spinning machinery.
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The grave of Richardson, his wife Meriel Forbes, and their son, Charles, in Highgate Cemetery in north London. In Witness for the Prosecution, a television remake of the 1957 film, he played the barrister Sir Wilfrid Robarts, co-starring Deborah Kerr and Diana Rigg. In America, it was shown on the CBS network in December 1982."Witness for the Prosecution (1982)", British Film Institute, retrieved 18 January 2014; and Smithies, Sandy.
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Her dissertation, Lattices of Functions, Measures, and Open Sets, was supervised by Frank Smithies. After completing her doctorate, she took a faculty position at the University of London. Following her husband's dream of living on a farm in Vermont, she moved to Dartmouth College in 1966. By 1972, she was working at the University of Hull and circa 2008 she became a professor at the University of Leeds.
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The first pastor in York was Rev John Smithies, who also established the Gerald Mission.Collins, Doris, The Establishment of Methodism in York, Barladong, No 3, 2002, The York Society, pp.14. While he was in York, tenders were called for construction of the "Wesleyan chapel" on 29 March 1853. Tenders were administered by John Henry Monger Snr,Perth Gazette and Independent Journal of Politics and News 1 April 1853, p.2.
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In 1870, settlers John Haufbauer and J.H. Minich built the first houses, smithies, and general stores on the site that would become Derby. In 1871, the community was named El Paso, after El Paso, Illinois, and was laid out and platted. In 1880, the Atchison, Topeka and Santa Fe Railway changed the name of its rail station to Derby, after railroad official C.F. Derby, to avoid confusion with El Paso, Texas.
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By the 18th century most of the common land had been enclosed forming landed estates and tenant farms where mixed farming was practised. Corn was ground into flour at local water mills – Finch Mill on the Calico Brook and Standish Mill on Mill Brook and skills associated with agriculture developed – smithies, wheelwrights and so on. Handloom weaving and basket making were also undertaken together with primitive coal mining in the Elnup Woods area.
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Comments from some solvers on these puzzles don't always agree with this assessment, rating maybe half of them as close to average broadsheet cryptic difficulty. ;The Guardian :Notable compilers of The Guardian's cryptic crosswords include Enigmatist, Pasquale, Paul (John Halpern again), Rufus (now retired), and the late Bob Smithies (Bunthorne) and Araucaria. The puzzle is edited by Hugh Stephenson. ;The Independent :The Independent went online only in 2016, but still has a cryptic crossword.
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Besides the tryworks, smithies and workshops, there were shops, churches, fortifications, gambling dens and even brothels.Prestvold (2001), p. 12 Such claims have no basis in reality, as noted above. No more than fifteen ships and 400 menIt is said that two hundred men slept or worked ashore at one time, but given the continual sunlight the men would have worked in shifts. So 200 men would have slept while a correspondent number would have worked.
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Born in Yorkshire, Smithies was living in Sheffield in 1827 when he was received into the Methodist ministry. In 1828 the Wesleyan Missionary Society appointed him as a missionary to Newfoundland where he spent nine years. In 1832 he was married to Hannah, his fiancée from England who assisted him in his work of "visiting the sick, leading classes and prayer meetings, as well as conducting the school".McNair, William and Rumney, Hillary.
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Also springing up were breweries, machine foundries, wool weaving factories, brickyards, printing shops and smithies making chains or nails. The town also became the regional agricultural hub with its livestock markets (later the Autumn Fair). Towards the end of the Second World War, the town was repeatedly bombed by Allied fighter-bombers and also by bigger aircraft. One air raid alone, on 6 January 1945, destroyed much of the town and killed 37 people.
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In 1919 Zembin was included into the BSSR, in 1927 lost the district center status, which it had received three years earlier. As of 1926 Zembin was inhabited by 1199 people, 838 of them were the Jews. There was a sewing workshop, a shoe-repair shop, 2 joinery shops, 3 tanneries, 5 smithies, a stream-meals, 2 bakeries, 2 oil-mills. 27 September 1933 the status of the place was reduced to a village.
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Between 1937 and her death she made many valuable contributions to the study of human genetics, and became a globally- renowned expert on multiple births. She was the first person to apply dermatoglyphics in the diagnosis of Down syndrome. She taught Oliver Smithies genetics in her lab and with him, demonstrated that haptoglobin types were inherited In 1966, she was awarded an honorary degree from Queen's University, Kingston for her scientific achievements.
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Following his arrival at Fremantle in May 1851 Wroth was sent to the York Convict Hiring Depot as a probationer prisoner working as a clerk. He received his ticket-of-leave on 28 November 1851. All this time Wroth had maintained his hopes for a future with Gartlett but she never reciprocated his attempts to contact her. In York his affections turned to John Smithies' young daughter, who wanted to elope with him.
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In 1980, the Lyckebo factory buildings were sold and the company closed down. Other industries in 20th century Storvreta included manufacture of cinema furnishings, two smithies delivering tools and other metal products to the furniture makers and farmers in the area, a dairy and a brewery. A fur farm breeding minks and silver foxes existed outside Storvreta until 1957. A mill, Ekeby kvarn, is located just outside the village, on the river Fyris.
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Mario Ramberg Capecchi (6 October 1937) is an Italian-born molecular geneticist and a co-winner of the 2007 Nobel Prize in Physiology or Medicine for discovering a method to create mice in which a specific gene is turned off, known as knockout mice. He shared the prize with Martin Evans and Oliver Smithies. He is currently Distinguished Professor of Human Genetics and Biology at the University of Utah School of Medicine.
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On July 1, 1940, the park hosted an exhibition fightAging Bull - Jack Dempsey's 1940 'comeback' was a sad and mercifully short spectacle, an April 17, 1995 article from Sports Illustrated between a 45-year-old Jack Dempsey and wrestler Clarence (Cowboy) Luttrell which Dempsey won. The park also hosted regular Friday night high school football games between Tech High Smithies and Boys' High Purple Hurricanes during the 1940s which sometimes outdrew the college games.
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After completing her PhD she joined the Medical Research Council (MRC) Laboratory of Molecular Biology (LMB) at the University of Cambridge. She briefly worked as a postdoctoral fellow at the Imperial Cancer Research Fund, working on the notch signaling pathway of zebrafish in gut development. Skipper joined Nature in 2001 as an associate editor for Nature Reviews Genetics. During her editorship she interviewed several high-profile scientists including Anne McLaren, Mario Capecchi and Oliver Smithies.
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In 1870, along with Angela Burdett-Coutts, she founded the Ladies Committee at the RSPCA. In 1875, she founded the first Band of Mercy. Smithies died in 1877; on her deathbed she stated: "the teaching of children to be kind and merciful to God's lower creatures is preparing the way for the gospel of Christ." She was buried in Abney Park Cemetery in Stoke Newington, with her son Thomas (who died in 1883).
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In 1492 the village had: two leather works, one furrier, three smithies, two mills (flour), one tailor, two butchers, one weaver, one locksmith, one rope-maker and one stonemason. Rope making and wire pulling became two of the strongest trades by 1577. By 1600 the village had 41 different trades living and working and was accorded the privilege of being a "Market Town". After the Anschluss, the area became part of the Reichsgau Oberdonau.
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Murphy signed for Championship side Huddersfield Town on a two-year contract, with the option of a further year in the club's favour, on 17 June 2014. Although he admits he will start as 2nd choice, he aims to challenge Alex Smithies for the goalkeeper spot. After making his début in the League Cup first round match against Chesterfield in August, he would make his league début against Sheffield Wednesday on 22 November 2014.
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In 1920, Blatteis was one of the leading organizers of New York City's Brownsville and East New York Hospital, for which he also served as the first President of the Medical Board. During that time, he was a member of various sessions of the American Congress on Internal Medicine.Frank Smithies, Ed., Annals of Medicine: With Abstract of the World's Literature (1920, 1921), Vol. 1, p. 34, 177, 187, 353, 363, 511, 521.
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De la Touche, in Smithies 2002, p.76 Another 35 soldiers with three or four French officers were assigned to ships of the King of Siam, with a mission to fight piracy. The disembarkment of French troops in Bangkok and Mergui led to strong nationalist movements in Siam directed by the Mandarin and Commander of the Elephant Corps, Phra Phetracha. By 1688 anti-foreign sentiments, mainly directed at the French and Phaulkon, were reaching their zenith.
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A second church, St Michael's, was built in the village of Mawnan Smith in 1876 and there was also a Wesleyan Methodist chapel in the village. The village name may derive from the fact that it once had four working smithies serving the many farms in the parish. By the early 20th century only one remained in business. It was operated by blacksmith Billy James followed by his son Dryden and closed when the latter died in 1994.
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Here, houses for livestock and people were typically built up from the actual shoreline. A typical medium-sized farm in the inland of Norway would include a dwelling house (våningshus), hay barn (låve), livestock barn (fjøs), one or more food storage houses (stabbur), a stable, and occasionally separate houses for poultry, pigs, etc. Houses that had separate heat sources, e.g., washing houses (eldhus) and smithies were usually kept separate from the other houses to prevent fires.
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I should be sorry if any of our Methodist friends or others > should be so deluded as to embark for such a place.McNair, William and > Rumney, Hillary. Pioneer Aboriginal Mission: The Work of Wesleyan Missionary > John Smithies in the Swan River Colony 1840-1855, University of Western > Australia Press, 1981. . Before long, the settlement began to fail owing to poor soils and climate — no water in summer and too much of it in winter — and the settlers drifted away.
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The Metaphysics of Attention; Christopher Mole; In Christopher Mole, Declan Smithies & Wayne Wu (eds.), Attention: Philosophical and Psychological Essays. Oxford University Press. pp. 60–77 (2011); Authors-Christopher Mole, University of British Columbia...Abstract-This paper gives a brief presentation of adverbialism about attention, and explains some of the reasons why it gives an appealing account of attention's metaphysics Metaphysics is considered one of the four main branches of philosophy, along with epistemology, logic, and ethics.
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Soon there were more shops, smithies, and a train station in the area. Nora Elementary School was opened in 1895. About 150 people lived in Nora in the 1880s, but the area did not become densely populated until the mid-1900s. Nora Plaza Shopping Center was built in 1959, anchored by an Ayr-Way that became a Target and a Standard that later became a Lowells No Frills Discount Foods, Wild Oats Market, and most recently Whole Foods.
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Smithies 2002, p.180 According to French missionary sources he was called Racha Mantri and was at the same time a supervisor of the Christians in Ayutthaya and the official in charge of the royal storehouses.Dhivarat na Prombeja, in Reid, p.258 In her later life, Maria, together with her daughter-in-law Louisa Passagna (widow of João), continued to sue the French East India Company to recoup money which her husband Phaulkon had lent to the company.
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Silva, A.J. and R. White, Thesis for a Ph.D. in the Department of Human Genetics, University of Utah: The genetics of human methylation. UMI, Bell and Howell Information Company, #3058. 1989. It was also in Utah, while working with Mario Capecchi, that he had the idea of bringing the newly developed mouse gene targeting approaches to studies of memory. Capecchi shared the Nobel prize with Martin Evans and Oliver Smithies for the development of gene targeting strategies in mice.
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Smithies developed the technique of gel electrophoresis using a starch matrix, as a sideline of (unproductive) research into an insulin precursor molecule, at the University of Toronto. This improved the ability to resolve proteins by electrophoresis. He was assisted technically in his later electrophoresis work by Otto Hiller. He used starch electrophoresis to reveal differences between normal human plasma proteins, and in collaboration with Norma Ford Walker, showed that the variation was inherited, which stimulated his interest in genetics.
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The local Imperial count moved into the castle and held court under a great linden tree with the local freemen. The castle's masters also forced merchants using the road down below to pay tolls. Charcoal works were set up in the forests, and in the dales, bloomeries and smithies were busy smelting and working iron. In 1238, the court was made a Zent (≈soke) of the Battenberg Counts, who then sold it to the Archbishop's Estate of Mainz.
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Shops produced items from clothes frames to the scythe sharpeners known as "Emmons rifles" to innovative horse-drawn hay rakes, to wagons and sleighs. Some operated in manufactories, others in barns or other farm buildings. The town also had a brickyard; tanneries; cattle dealers; and smithies where workers shoed animals, produced knives and made other implements. Mass production and new technologies threatened these small businesses in much the same way rising costs and external competition had affected agriculture.
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He received the accolade from Prince Charles at Buckingham Palace on 25 June 2004. In 2007, he was awarded the Nobel Prize in Physiology or Medicine along with Mario Capecchi and Oliver Smithies for their work in discovering a method for introducing homologous recombination in mice employing embryonic stem cells. Evans was appointed president of Cardiff University and was inaugurated into that position on 23 November 2009. Subsequently, Evans became Chancellor of Cardiff University in 2012.
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Due to natural resources comprising the reach forestry and shallow deposits of bog iron ore, the industrial traditions of Pisz are connected with wood processing (the sawmill) and metallurgy. There are iron works in Wądołek, as well as the industrial smithies in Wiartl and in Jaśkowo. The wood processing industry has a long tradition in Pisz. The core of the industry is its sawmill, supporting a broadbase plywood industry with a plant called Zakłady Przemysłu Sklejek.
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Planning requests included that the canal should not pass within 500 metres of Pype Hayes Hall. By the mid-1700s, Erdington had a population of under 700 and within its boundaries were 52 roads, one forge, 40 farms, 96 cottages, two smithies and a shop. By 1832, it had a population of 2,000. Erdington has had historic ties with both Castle Bromwich and Water Orton through administration, governance and land ownership whilst being part of Aston Parish.
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Enjoy Contemporary Art Space is a contemporary art space in Cuba Street arts area of Wellington, New Zealand. Commonly known as 'Enjoy', the gallery was founded in 2000 by artists Ciaran Begley, Ros Cameron and Rachel Smithies as an artist-run space. Today, Enjoy operates as a not-for-profit contemporary art space, presenting exhibitions, publications, public programmes and residencies by emerging and mid-career artists. Enjoy is supported by Creative New Zealand and the Wellington City Council.
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Ruins of the residence of Constantine Phaulkon and his wife Maria Guyomar de Pinha in Lopburi, Thailand. Phaulkon's Catholic Japanese-Portuguese wife, named Maria Guyomar de Pinha,Note 9, Smithies 2002, p.100 who had been promised protection by being ennobled a countess of France, took refuge with the French troops in Bangkok, where she was able to stay from October 4-18, 1688. She had managed to flee Ayutthaya with the help of a French officer named Sieur de Sainte- Marie.
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Mr. Smithie had asked Kimberly to play Cleopatra in a future production but sadly Mrs. Cavanaugh Smithie decided she did not wish to include Kimberly as a director or actress for fear of her getting the credit for their restorations. The theater was restored and Kimberly attended the opening but then returned to live in Australia with her former husband and daughter. Cavanaugh and Smithies operated the Greenwoods Theater until early 2007, when financial difficulties forced them to close the venue.
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Conditional gene knockout is a time-consuming procedure and there are additional projects focusing on knocking out the remaining mouse genes. The KOMP project contributor, Oliver Smithies, arguably provided the biggest scientific impact on this gene targeting. Oliver received the Nobel prize for medicine due to a technique allowing the ability to identify functions in genes and how to use the 'knockout' method to delete certain genes. Unfortunately, the pioneer in gene targeting died at the age of 91 on January 10th, 2017.
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He said that his love of science came from an early fascination with radios and telescopes. He attended Balliol College, Oxford on a Brackenbury Scholarship, initially reading medicine. He studied anatomy and physiology, winning a prize in anatomy, and graduated with a first-class Bachelor of Arts degree in animal physiology, including biochemistry, in 1946. Inspired by tutorials from Alexander G. Ogston on applying physical chemistry to biological systems, Smithies then switched away from medicine to earn a second bachelor's degree in chemistry.
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A second embassy to Siam was sent in March 1687.Mission Made Impossible: The Second French Embassy to Siam, 1687, by Michael Smithies, Claude Céberet, Guy Tachard, Simon de La Loubère (2002) Silkworm Books, Thailand organized by Colbert, of which Tachard was part again. The embassy consisted in five warships, led by General Desfarges, and was bringing the Siamese embassy home. The mission was led by Simon de la Loubère and Claude Céberet du Boullay, director of the French East India Company.
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The land was formerly part of the manse field of the Wesleyan glebe lands granted by the Government in 1852 to John Smithies in connection with his coming to York to establish the Gerald Mission to train aboriginal children for farm work.Pamela Stathem Drew and AM (Tony) Clack: York Western Australia, A Documentary History, Pandorus Publications, 2018, p.67; Landgate Crown Grant 1074. In 1886, Rev Bird offered the land to the Council,Eastern Districts Chronicle 22 May 1886, p.3.
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Etheridge's impressive form led to him being nominated for the August Player of the Month award. Cardiff were relegated from the Premier League after finishing in 18th position with Etheridge winning the club's Player of the Year award. On the opening day of the 2019–20 season, Etheridge suffered a hamstring injury during a 3–2 loss at Wigan Athletic, which ruled him out for two months. Alex Smithies replaced Etheridge as Cardiff's first choice goalkeeper for most of the season.
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Mission Made Impossible: The Second French Embassy to Siam, 1687, by Michael Smithies, Claude Céberet, Guy Tachard, Simon de La Loubère (2002) Silkworm Books, Thailand . With the king and his heirs out of the way, Phetrachathen usurped the throne and officially crowned himself King of Ayutthaya on August 1. King Phetracha took Mergui back from French control almost immediately, and began the pivotal Siege of Bangkok, which culminated in an official French retreat from Siam. Pretacha's reign, however, was not stable.
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After the Dissolution of the Monasteries Matthew Wentworth bought "all the myne, and delff of ironstone" around Bentley Grange, the Byland Abbey property. Though the ironstone was exhausted by the mid-1600s, smithies continued to operate fuelled by charcoal. The furnace at Bretton supplied pig iron to Colnebridge, Wortley Top Forge and Kirkstall in 1728. The furnace at Bretton was taken over by the Cockshutts of Wortley and pig iron was produced there in 1806 but the site had closed by 1820.
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In the late 1700s, the river held good populations of fish. Industrial development of the valley consisted of several deep coal mines, but they were fairly small, and did not significantly pollute the river. There were collieries at Smithies, Honeywell, Queens Ground and Mount Osborne. The opening of the Dearne and Dove Canal in 1810 had serious impacts on the river, as it provided a way to transport the coal to Sheffield and Rotherham, where it was used in the steelworks.
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The tremendous utility of knockout mouse technology was recognized in 2007 with the Nobel Prize in Physiology or Medicine to Drs. Mario Capecchi, Martin Evans, and Oliver Smithies.2007 Nobel Prize Laureate – Medicine In developing small molecule drugs for its validated targets, Lexicon uses medicinal chemistry known as "click chemistry." Dr. K. Barry Sharpless, who was awarded the 2001 Nobel Prize in Chemistry,2001 Nobel Prize Laureate – Chemistry pioneered this set of powerful and reliable tools for the rapid synthesis of novel compounds.
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They are widely used in knockout experiments, especially those investigating genetic questions that relate to human physiology. Gene knockout in rats is much harder and has only been possible since 2003. The first recorded knockout mouse was created by Mario R. Capecchi, Martin Evans, and Oliver Smithies in 1989, for which they were awarded the 2007 Nobel Prize in Physiology or Medicine. Aspects of the technology for generating knockout mice, and the mice themselves have been patented in many countries by private companies.
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Shortly thereafter two more wickets fell: Illingworth was caught and bowled by Smithies for 4, while Emily Drumm was caught by Chamberlain off the bowling of Smith for a duck. From 55 for one, New Zealand had collapsed to 71 for five. Lewis and Gunn added 39 runs together, but once Lewis was dismissed for 28, trapped leg before wicket by Smith, New Zealand subsided, and were bowled out for 128. England won by 67 runs, and secured their second World Cup title.
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The results were published in 1992, in a highly cited paper in Science. The ApoE knockout (apoe−/−) was the earliest mouse model of the disease, and has been widely used in atherosclerosis research. Oliver Smithies, Maeda's husband and long-term collaborator Maeda's group subsequently carried out other gene- targeting experiments, including replacing the mouse gene for ApoE with common variants of the human gene. As of 2017, her research continues to focus on atherosclerosis, and encompasses molecular pathology as well as genetics.
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Nussey was the twelfth child of John Nussey (1760–1826), a cloth merchant of Birstall Smithies, near Gomersal in the West Riding of Yorkshire, and his wife Ellen, née Wade (c. 1771–1857). She attended a small local school before progressing to Gomersal Moravian Ladies Academy. Nussey met Mary Taylor and Charlotte Brontë in January 1831, when they were pupils at Roe Head School, near Mirfield in Yorkshire. They corresponded regularly over the next 24 years, each writing hundreds of letters to the other.
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The site now occupied by the estate was once farmland and woodland. A large area from Lee Lane was known as Athersley Wood, which stretched nearly to Carlton Hill. The name was first recorded in 1379 as 'Hattirslay', probably meaning 'Aethred's forest glade' from the Old English 'Aethe[l]red' and 'leah'.On Our Street: Life in Athersley, New Lodge and Smithies, Roundhouse Community Partnership, 2006, p7 Construction began in post war Britain, near the end of the 1940s, under the direction of the then Building Administrator.
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There was a proviso that if there were no aborigines present, the land was to revert to the government. Smithies wrote on 26 September 1851 that eight natives and one white man had travelled to York from Wanneroo with a bullock team, a journey which had taken three days. The party set up tents and cleared ten acres of ground at the selected farm location ready for planting the next year. The mission was to be called Gerald Mission in honour of the Governor.
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Australia v Bangladesh AFC Match Report Ikonomidis was named in the Olyroos squad for the 2016 AFC U-23 Championship,Olyroos squad: Aurelio Vidmar confirms squad for AFC Under 23s Championship Tom Smithies, Fox Sports, 23 December 2015 although he was recalled later from the camp by Lazio for his loan to Salernitana. 30 December 2018, Chris scored his first international goal for Australia against Oman in an international friendly in the UAE. Ikonomidis scored off a cross by Awer Mabil from within the box.
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In the post-World War II period, Hans Penth authored 24 articles between 1967 and 2003, though many were short notes. The largest contributors were Michael Smithies, 22 articles between 1971 and 2002, Phraya Anuman Rajadhon, 19 articles between 1951 and 1967, and Michael Vickery, 13 articles between 1973 and 1995, including his translation of the only chronicle text discovered in the 20th century. The largest span was achieved by Barend Jan Terwiel who authored 11 articles over 47 years from 1972 to 2019.
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Taylor (back row, second from right) in a Manchester United team photo in 1957 He was born in Smithies, near Barnsley, in January 1932, one of six children born to Charles and Violet Taylor. He was a pupil at Raley Secondary Modern School where he attended after failing his eleven-plus. Taylor left school in 1947 at the age of 15 began his career playing for a local coal mining team at the colliery where he worked. Two years later, he signed for Barnsley.
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The first "Band of Hope" in London was formed at her house by Thomas Bywater Smithies and it included some of her neighbours and children. Her husband and two youngest children died in 1847. Five years later she was in Darlington where she took an interest in improving the lot of children, in particular, in the local workhouse. She had a long decline starting in 1859 in Darlington that progressed via a stroke and taking her to London where she died in Penge in 1798.
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A number of kitchens at Pompeii had no roofs, resembling courtyards more than ordinary rooms; this allowed smoke to ventilate. Kitchens that did have roofs must have been extremely smokey, since the only ventilation would come from high windows or holes in the ceiling; while the Romans built chimneys for their bakeries and smithies, they were unknown in private dwellings until about the 12th century A.D, well after the collapse of Roman civilization.Faas, p. 140.James Burke, Connections (Little, Brown and Co.) 1978/1995, , p.
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Despite the depression of the 1880s and 1890s, the Methven library was built in 1880s, Methven School was opened in 1882 with 41 pupils, the Anglican church was built in 1880 and the Catholic church in 1888. The population of Methven town was 300 people in 1902. Methven contributed troops to the First World War with 69 on them losing their lives. In the 1920s Methven slowly changed from having livery stables and smithies to garages and engineering firms to service cars and farm machinery.
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Before the match, England's women had received a good luck message from the England men's team, who had just lost the Ashes to Australia. Smithies, speaking after the victory, aimed a good-natured dig at them; "Perhaps they could learn a few things from this." England's victory gave women's cricket unprecedented coverage in the English press; it was featured in all the national newspapers, and was even on the front pages of some. There was an item on the win in the BBC Evening News.
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Adam Armstrong's placed finish after Barbet's attempted clearance following a free kick gave Barnsley the lead in the first half. Sam Winnall tapped home after Ryan Kent's shot rebounded off the inside of the post to secure the win. Brentford travelled to Loftus Road to face Queens Park Rangers in the first West London derby of the season. Clarke wriggled around the defenders in the box from McEachran's pass and slotted the ball under goalkeeper Alex Smithies just before half-time to give the Bees the lead.
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Page from the British Workman, 1865 The British Workman was an English broadsheet periodical, published monthly by Partridge and Co in London. The British workman The publishing house of S. W. Partridge & Co. was founded by Thomas Bywater Smithies of York in 1855 in order to publish The British Workman.The British Workman Magazine - Archives Hub It was published between 1855 and 1892, and aimed to "promote the health, wealth and happiness of the working classes". It was illustrated with contemporary engravings, with some editions having the first page given over to a single engraving.
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Iron examples from the later Iron Age have been found in pre-Roman settlements in several English counties, as well as in France and Germany, where it is called "Hippe" or "Sechsle", and Switzerland, where it is called "Gertel". The tool has developed a large variety of names in different parts of Britain, including bill, hedging bill, hand bill, hook bill, billhook, , brushing hook and broom hook. In American English a billhook may sometimes be called a "fascine knife". Made on a small scale in village smithies and in larger industrial sites, e.g.
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Section of the Roman city wall The first inhabitants of what is now Nantes settled during the Bronze Age, later than in the surrounding regions (which have Neolithic monuments absent from Nantes). Its first inhabitants were apparently attracted by small iron and tin deposits in the region's subsoil. The area exported tin, mined in Abbaretz and Piriac, as far as Ireland. After about 1,000 years of trading, local industry appeared around 900 BC; remnants of smithies dated to the eighth and seventh centuries BC have been found in the city.
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Second, sensitivity to arousing stimuli may be intermittently presenting in individuals with ASD. Third, the stimuli employed in habituation paradigms cannot easily mimic real life non-laboratory-based events. Animal research on arousal has attempted to link deficiencies to conditions such as attention-deficit hyperactivity disorder, Alzheimer's disease, and autism.Garey, Goodwillie, Frohlich, Morgan, Gustafsson, Smithies, Korach, Ogawa and Pfaff, 2003 Historically, hypo-arousal in people with an ASD has also been proposed as a factor to specific stimuli,Rimland, 1964; DesLauriers and Carlson, 1969 although with limited laboratory evidence.
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Marshal Desfarges, also spelled Des Farges (died 1690), was a French general of the 17th century who took an important role in French efforts at establishing a presence in Siam (modern Thailand). Desfarges led two battalions (636 soldiers) on board five warships, in the second French embassy to Siam. The embassy to King Narai, under the special envoys Simon de la Loubère and Claude Céberet du Boullay, left France for Siam in March 1687.Smithies (2002) Desfarges had instructions to establish French troops in Mergui and Bangkok, if necessary by force.
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Oliver Smithies (23 June 1925 – 10 January 2017) was a British-American geneticist and physical biochemist. He is known for introducing starch as a medium for gel electrophoresis in 1955, and for the discovery, simultaneously with Mario Capecchi and Martin Evans, of the technique of homologous recombination of transgenic DNA with genomic DNA, a much more reliable method of altering animal genomes than previously used, and the technique behind gene targeting and knockout mice. He received the Nobel Prize in Physiology or Medicine in 2007 for his genetics work.
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The district produces tobacco""Бритиш Американ Тобакко" Ургутский Филиал, табак ферментированный" ("British-American Tobacco Company, Urgut branch, cured tobacco"), in Russian, accessed 6 June 2009 and wool and silk products."Uzbekistan: Searching the Heart of Central Asia", accessed 16 January 2008, from Internet Archive Urgut town has market days every weekend, and is one of the largest market towns in the region. The district is home to carpets, jewels, metalwork and ceramics. The market also has smithies, tin workshops and stalls selling locally produced tea sets, clothes and traditional leather boots.
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Fraser told fans via Twitter that "['Something in the Water'] is a bit different to what you might be used to from me". Scott Kara from The New Zealand Herald called the song "a right little thigh-slapper, with a bit of a stomp to it, and it's about good times, drinking wine, and being in love." The Sunday Star-Times' Grant Smithies referred to it as "an unexpectedly perky country-pop ditty built around a rollicking bluegrass stomp." Both writers compared the song to the busts of Dolly Parton.
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According to the book by Frank Smithies (Cauchy and the Creation of Complex Function Theory, Cambridge University Press, 1997, p. 177), Augustin-Louis Cauchy presented a theorem similar to the above on 27 November 1831, during his self-imposed exile in Turin (then capital of the Kingdom of Piedmont-Sardinia) away from France. However, according to this book, only zeroes were mentioned, not poles. This theorem by Cauchy was only published many years later in 1874 in a hand- written form and so is quite difficult to read.
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Smithies were generally owned by landowners and leased to smiths, who were not organised into guilds, unlike their counterparts in Coventry. This freedom from price and production control may in part explain the industry's sudden growth in the seventeenth century, which caused rivalry with guilds in London who attempted to stop the flow of Midlands goods into their markets. The greatest benefits of the trade accrued to ironmasters who purchased goods from the local producers for sale onwards. Nailmaking also established itself in the northern parts of the county, such as Bromsgrove, Stourbridge and Dudley.
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E. S. Pondiczery was another pseudonym invented by Boas and Smithies as the fictional person behind the "H. Pétard" pseudonym, and later used again by Boas, this time for a serious paper on topology, Power problems in abstract spaces, Duke Mathematical Journal, 11 (1944), 835–837. This paper and the name became part of the Hewitt-Marczewski- Pondiczery theorem. The name, revealed in Lion Hunting and Other Mathematical Pursuits cited above, came from Pondicherry (a place in India disputed by the Dutch, English and French) and a slavic twist.
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When the school colors of brown and gold were selected, they decided to go with the nickname of "Golden Bears." The Waynedale student section during athletic events is called the "Bear Den". Waynedale has a strong rivalry with the Triway High School Titans that dates back to when both schools were members of the WCAL from 1955-1970. Due to the recent success of all three teams, Waynedale's football team also has a strong rivalry with both the Dalton High School Bulldogs and the Smithville High School Smithies.
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The Sint Andries bulwark around 1770 New Amsterdam has its origins in a village which grew up alongside Fort Nassau in the 1730s and 1740s. The first Nieuw Amsterdam, as it was called then, was situated about up the Berbice River on the right bank. Before the 1763 slave uprising it comprised a Court of Policy building, a warehouse, an inn, two smithies, a bakery, a Lutheran church and a number of houses, among other buildings. Built in 1740 by the Dutch, New Amsterdam was first named Fort Sint Andries.
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According to Schwarzenbach's biographers, Clarac was gay and theirs was a marriage of convenience for both of them, to have Schwarzenbach, who was lesbian, obtaining a French diplomatic passport enabling her to travel without restrictions. They were friends and when Schwarzenbach sustained a serious head injury and was dying, Clarac rushed from Tetuan to her deathbed in Engadin, but Schwarzenbach's mother, Renée Schwarzenbach-Wille, forbade everyone to see the daughter. Clarac adopted one son, Henri Pageau-Clarac. In 1971, with Michael Smithies, he wrote Discovering Thailand, published with Siam Publications.
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Tourism and vineyards development protected by Government Laws are now the byword for the "Golden Wachau," as it is now nicknamed. In the modern period though, the 18th-century buildings are now integrated with the town layout, and they are used for promotion of trade and crafts. The 15th and 16th centuries' ambiance is witnessed in the "towns' taverns or inns, stations for changing draught horses, boat operators' and toll houses, mills, smithies, or salt storehouses". The valley and the towns, still preserve a number of castles of vintage value.
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Italian Court in Kutná Hora The Italian Court () is a palace in Kutná Hora. Originally, it was the seat of the Central Mint of Prague; it was named after the Italian experts who were at the forefront of the minting reform. The main area of the mint consisted of coin-makers-workshops, or Smithies, which were located around the courtyard, and the minting chamber, called “Preghaus”, where the Prague groschen were struck. After its reconstruction at the end of the 14th century, the Italian Court became a part-time royal residence.
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The zoo lies within a plot of land off Smithies Lane in Heckmondwike, West Yorkshire. It is laid around a small lake and comprises various animal enclosures, a ticket office, cafe, lakeside restaurant, reptile house, adventure play area and guest amenities. The zoo's animal collection has gradually expanded since its beginnings in 1991 as a "rare breeds farm" with Highland cattle, llamas, wallabies and emus. As of 5 May 2020, the zoo's collection of over 120 animals includes serval, Scottish wildcats, lemurs, reindeer, coati, otters and raccoon dogs, plus various birds, reptiles and small invertebrates.
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The lands of the Abbey were divided into agricultural units or granges, on which local people worked and provided services such as smithies to the Abbey. William Giffard, Bishop of Winchester introduced the first colony of Cistercian monks to England at Waverley, Surrey, in 1128. His first cousin, Walter de Clare, of the powerful family of Clare, established the second Cistercian house in Britain, and the first in Wales, at Tintern in 1131. The Tintern monks came from a daughter house of Cîteaux, L'Aumône Abbey, in the diocese of Chartres in France.
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Allan was born on 13 August 1936 in Southgate, Middlesex, England. After serving in the Royal Air Force from 1955 to 1957, he entered Sidney Sussex College, Cambridge, and continued at Cambridge for his graduate studies, receiving a PhD in 1964 under the supervision of Frank Smithies. Allan spent most of his career at Cambridge, with interludes as a Lecturer in Pure Mathematics at Newcastle University from 1967 to 1969 and as Professor of Pure Mathematics at the University of Leeds from 1970 to 1978.Obituaries: Graham Allan, Leeds University Campusweb, August 14, 2007.
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Former Magazine drummer Martin Jackson briefly replaced Lever during 1982–83 while the latter was on sabbatical. After performing several radio sessions for BBC Radio 1 DJ John Peel, the band were signed to Epic Records, then a subsidiary of CBS Records International, and in March 1982 released their debut single, "In Shreds", which was produced by Steve Lillywhite. The single's cover – a harrowing painting by Smithies, who created the artwork for all of their releases – mirrored the band's tense, atmospheric sound. During this time, the Chameleons' independent style clashed with their label's visions for the band.
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New Zealand won the toss, and captain Maia Lewis chose to bat first. New Zealand lost the early wicket of Emily Drumm for four, however they went on to a score of 93 before another wicker fell. Debbie Hockley top scored with 43, and Shelley Fruin (29), Katrina Keenan (35) and 28 extras took New Zealand to 175/6 from their 50 overs.England Women v New Zealand Women – Hero Honda Women's World Cup – 2nd Semi Final from CricInfo retrieved 2 June 2008 England's bowlers bowled economically, with three going at economy rates of under 2.90, and medium-pacer Karen Smithies took 3/40.
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The Shakerleys finally left the Old Hall in about 1520 and the family migrated to Cheshire. The last of the Shakerleys to live at Shakerley Old Hall, Hugh, was buried in Leigh and the hall became a farmhouse. In 1646 the Royalist Geoffrey Shakerley was ordered to pay a fine and sequestration of his lands for his support of King Charles I. They included Shakerley Old Hall, land and the corn mill, and five nail smithies at Shakerley. In 1667 Shakerley Old Hall was a magnificent home containing the hall, cellars, brewhouse, buttery, dairy, dining room, parlour and various chambers.
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Prestbury 1831 The school, smithies, the mill, inns and the stocks centre on a village street called "The Village", which is broad enough for cattle fairs and the like. Until the 19th century the village street was connected to Pearl Street, the main street of Butley, by a ford. In about 1825, a bridge of two arches was built, linking the village street to a new road ("New Road") passing behind the cottages and the Admiral Rodney pub on the southeast side of Pearl Street. In 1855 the bridge was replaced by the present bridge with one arch.
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The Quilombo dos Palmares, the largest and most well-known of these settlements, was founded around 1600 in the Serra da Barriga hills, in the present state of Alagoas. Palmares, at the height of its power, was an independent, self-sustaining republic, hosting a population of over 30,000 free African men, women and children. There were over 200 buildings in the community, a church, four smithies, and a council house. Although Palmares managed to defend itself from the Dutch military and the Portuguese colonials for several decades, it was finally taken and destroyed and its leader Zumbi dos Palmares was captured and beheaded.
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New Lodge is a housing estate in Barnsley in South Yorkshire, England. The ' New Lodge' estate is located to the north of Barnsley on the A61 near Athersley. The earliest reference to New Lodge dates from 1377, when the area was referred to as 'Newe Laythes', becoming New Laithes in 1541.On Our Street: Life in Athersley, New Lodge and Smithies, Roundhouse Community Partnership, 2006, p. 7 Maps from 1850 show 8 or 9 farm outbuildings at New Lodge, together with the large stone built manor house with its long carriageway and the 'Roundhouse' lodge on the Wakefield Turnpike (now the A61).
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There are two basic technical approaches to produce genetically modified mice. The first involves pronuclear injection, a technique developed and refined by Ralph L. Brinster in the 1960s and 1970s, into a single cell of the mouse embryo, where it will randomly integrate into the mouse genome. This method creates a transgenic mouse and is used to insert new genetic information into the mouse genome or to over-express endogenous genes. The second approach, pioneered by Oliver Smithies and Mario Capecchi, involves modifying embryonic stem cells with a DNA construct containing DNA sequences homologous to the target gene.
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He appeared in England amateurs' next match, though with less success, and then reverted to playing for Northern Nomads and, in a brief return to the Football League on the opening day of the 1931–32 season, alongside Joe Bradford and Johnny Crosbie for Birmingham in the First Division.Matthews, p. 174. He was called up again for the England amateur XI in November 1931, as a replacement for the injured Vivian Gibbins of West Ham United. Smithies made his debut for Corinthian on 13 February 1932, when he scored in a 4–3 defeat at Bradford City.
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Sandviken is also home to a number of cultural activities: Kulturskolan means "the culture school" (extramural music, dance and drama training), Sandviken Big Band, Sandviken Symphonic Orchestra and many musicians in the region. Sandvikens Art Gallery shows throughout the year various interesting exhibitions. Amongst the many popular tourist attractions in the municipality, the following merit special mention: the attractive old, carefully restored industrial villages in Gysinge and Högbo Bruk with their forges and smithies, handicraft, manor houses and possibilities they offer for outdoor recreation. During the winter months the downhill skiing facilities and the Snowpark at Kungsberget attract many visitors.
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The Northern Tasmanian Alpine Club formed in 1929 and pioneered trips to the mountain and improved the access track. In July 1929 Fred Smithies, a pioneer of skiing on Ben Lomond, accompanied the Tasmanian government's Tourism Director on a field trip to the plateau with the aim of establishing the feasibility of a skifield. Their route was by way of English Town, Ragged Jack and the headwaters of River O'Plain Creek (see image). This route had the disadvantage that it involved an extended walk to get onto the plateau but was less steep than the alternative access from Blessington.
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Throughout the 2009–10 season, Smithies was the only player to play in each and every league and cup match for Huddersfield. He made 48 starts, 17 of which resulted in a clean sheet for the Terriers. His contribution in helping Huddersfield to a final position inside the League One playoffs was reflected by him winning the club's Young Player of the Year Trophy. In conceding just 56 goals in such a competitive campaign, he won both praise and admiration from many quarters; earning the Football League's 'Young Player of the Month' award in February 2010 along the way.
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The village of Thonburi, on the right (west) bank of the Chao Phraya (here in the lower left corner of the map), facing the fortress of Bangkok, during the 1688 Siege of BangkokJean Vollant des Verquains History of the revolution in Siam in the year 1688, in Smithies 2002, p.95–96 Taksin took important steps to show that he was a worthy successor to the throne. He ensured appropriate treatment to the remnants of the ex-royal family, arranged a grand cremation of the remains of Ekkathat, and tackled the problem of establishing the capital.Damrong Rajanubhab, p.
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Leyburn State School ca. 1875 The settlement on Canal Creek (a tributary of the Condamine River) had grown from the 1840s to service the colonising settlers following the stock route blazed by the Leslie brothers in 1840 to the southern Darling Downs. Known from 1853 as Leyburn, the first sale of allotments was held in 1857 following the survey of the town earlier that year. By 1872 a state school, an Anglican church, Police Station and Court House, two smithies, three stores, a sawmill and the inevitable three hotels made up the straggling wooden town centre of Leyboard along the road to Warwick.
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For hundreds of years nails had been made in the Black Country, and many thousands of men and women were employed in the trade. It was the staple industry until the mid-19th century. Nail making by hand went into decline after the introduction of machine made nails in about 1830 and many nail makers adapted their smithies and forges, and redirected their skills to making chain. Cradley is less famous for coal mining than chain making, but between 1850 and 1950 the collieries were no less important than the chain works in the local economy and for the legacy they left.
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Before the October 1917 Revolution, there were three synagogues, a bath house by the river, a cemetery, two drug stores, two hotels, four smithies, four mills, three water mills and a steam mill, two barber shop, a diner, and many stores and workshops inside the shtetel center. Once a week a big market was arranged at the Market Place, where peasants sold their goods and bought the goods that the Jewish shop owners and craftsmen were selling. There were 220 houses in Pliskov, in which, according to the first census conducted in 1892, lived 1,320 Jews. The houses varied.
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The section "Fire hazards in the City" is based on Hanson (2001), 77–101 unless otherwise indicated. The only major stone-built area was the wealthy centre of the City, where the mansions of the merchants and brokers stood on spacious lots, surrounded by an inner ring of overcrowded poorer parishes whose every inch of building space was used to accommodate the rapidly growing population. These parishes contained workplaces, many of which were fire hazards—foundries, smithies, glaziers—which were technically illegal in the City but tolerated in practice. The human habitations were crowded, and their design increased the fire risk.
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This became known as the Cradle Mountain-Lake St Clair National Park. The year before Emmett had visited the mainland states to gain ideas for promoting tourism, and was impressed by the new sport of snow skiing. He returned with six pairs of skis and helped introduce the sport to southern Tasmania at Mount Field National Park in the winter of 1922. In 1929, with Fred Smithies and Carl Stackhouse, he was among the first to test the ski slopes of Ben Lomond in Northern Tasmania, along with Geoffrey Chapman who also skied Ben Lomond the same year.
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A portrait of Kosa Pan by Charles Le Brun, 1686 Siamese embassy to Louis XIV led by Pan in 1686, by Nicolas Larmessin To accompany the return of the 1685 French embassy to Siam of Chevalier de Chaumont and François-Timoléon de Choisy, Pan was selected by Constantine Phaulkon, the Prime Counsellor to King Narai, to lead an embassy to France. Pan set out for France in 1686 on two French ships with two other Siamese ambassadors, Ok-luang Kanlaya Ratchamaitri and Ok-khun Si Wisan Wacha,Smithies (1999), p. 59 and by the Jesuit Father Guy Tachard.Gunn, p.
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Riverhead had a variety of country industries typical of the area, including a tannery, a timber yard, smithies and the posting house. The economy was based mainly on agriculture, along with some gravel and sand quarrying to the north east of the village that created the lakes around Bradbourne which are now a wildfowl reserve. The village has a central conservation area that covers some 10.0 hectares and contains about 30 listed buildings. The listed properties in the Conservation Area date from the 17th and 18th Century and the older unlisted properties date mainly from the 19th Century.
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He became an assistant and manservant to Charles Darwin during the voyage and for a few years afterwards before emigrating to Australia. In 1854 he became Postmaster of Pambula, and managed an inn called the Forest Oak Inn which still stands at a bend on the coast road. The main land uses were grazing and agriculture, and tented accommodation on stock routes was replaced by slab and bark huts, then by more permanent buildings providing homes, housing, smithies, and hotels. Pambula had five licensed hotels by 1856 and the foundation stone for the courthouse was laid in 1860.
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On 12 September 2013, the company announced that it was closing after 23 years of business. The closure came as a result of the company struggling to raise money to support future development projects, with the demise of THQ, a major client, said by Philip Oliver to have hit the company particularly hard. The company is reported to have owed £2.2 million to staff and creditors. The Oliver brothers along with the former company's COO Richard Smithies almost immediately formed a new company, Radiant Worlds, in the same town, and were reported to have recruited up to 50 former Blitz staff.
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According to Desfarges himself, Phetracha demanded her return, threatening to "abolish the vestiges of the (Christian) religion", and he further captured dozens of French people to obtain her return: the Jesuit Father de La Breuille, 10 missionaries, fourteen officers and soldiers, six members of the French East India Company, and fourteen other French people (including three ship captains, three mirror technicians, Sieur de Billy, governor of Phuket, a carpenter named Lapie, and the musician Delaunay).Desfarges, in Smithies 2002, p.50 Desfarges, afraid of compromising the peace agreement and resuming a full conflict, returned her to the Siamese on 18 October, against the opinion of his officers.Smithies 2002, p.
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The land, originally dense woodland populated by a variety of wildlife, proved difficult to prepare, yet the need for more housing gave rise to an influx of labourers, many of whom stayed on in the houses they helped to build. This undertaking was instrumental in the decision to build more homes around the region, including 'Phase 2' of Athersley, which was later to become known as Athersley North. North and South are separated by a main B road, Laithes Lane. The adjoining estate of New Lodge is separated by Wakefield Road from Athersley North yet other estates surrounding the area have no noticeable separation, most notably Smithies and Monk Bretton.
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Smithies and Fielding formed the Reegs with the help of vocalist Gary Lavery and a drum machine, and released two albums, Return of the Sea Monkeys (1991) and Rock the Magic Rock (1992), on the independent label Imaginary Records. Burgess released his debut solo album, Zima Junction, in 1993, and toured America the following year with his backing band the Sons of God. He released another studio album, Spring Blooms Tra-La (1994), as well as a live album, Manchester 93 (1994), before partnering with Yves Altana in 1995, releasing Paradyning the same year. Afterwards, he founded Invincible with Altana and drummer Geoff Walker.
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This was opposed by engineer Solomon Cook who was in the process of constructing his mill in the town. So much time and labour was spent on clearing 20 to 30 acres of land and the construction of buildings, and with Rev Smithies often unavoidably away and with few others helping him, the aboriginal children drifted away from the mission school and the mission failed.Inquirer 16 March 1853, p.3. The Protector of Natives in York, Walkinshaw Cowan blamed the loss of students from the mission school to "yearning" or "strong particularity" to their own districts but also due to high death rates from influenza at the institution.
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The ruins of the old Lylestone Row still stand (2012) on the roadside beyond Monkredding House, opposite to the old Monkredding Quarry and close to the old Sevenacres Quarry. In the 19th century the row contained circa nine dwellings with several buildings on the opposite side of the road. These dwellings were home to railway workers and quarrymen from the nearby extensive freestone and limestone quarries and coal pits. At least three smithies once stood in the quarries near to the row and a mineral railway ran up to the site, running through the woods, parallel to the main road from the old Kilmarnock to Dalry mainline railway.
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Her hypothesis was confirmed in 1975 upon analysis of an immunocompromised patient exhibiting normal ADA activity but defective purine nucleoside phosphorylase (PNP) activity. Within several years, ten more cases of immune deficiency linked to PNP mutations were described, leading to the classification of the disorder as purine nucleoside phosphorylase deficiency. Giblett's other notable discoveries include T cell immunodeficiency. Throughout her career, Giblett collaborated with some of the most notable and talented scientists of her era, including: Oliver Smithies, Alexander Bearn, James Neel, Curt Stern, Victor McKusick, Ernest Beutler, Stanley Gartler, Walter Bodmer, John Cairns, David Weatherall, Henry Kunkel, H. Hugh Fudenberg, and Newton Morton.
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Sir Martin John Evans (born 1 January 1941, Stroud, Gloucestershire) is a Welsh scientist who, with Matthew Kaufman, was the first to culture mice embryonic stem cells and cultivate them in a laboratory in 1981. He is also known, along with Mario Capecchi and Oliver Smithies, for his work in the development of the knockout mouse and the related technology of gene targeting, a method of using embryonic stem cells to create specific gene modifications in mice. In 2007, the three shared the Nobel Prize in Physiology or Medicine in recognition of their discovery and contribution to the efforts to develop new treatments for illnesses in humans.
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The disembarkment of Desfarges troops in Bangkok and the troops of his officer du Bruant in Mergui led to strong nationalistic movements in Siam directed by Phra Petratcha and ultimately resulted in the 1688 Siamese revolution in which King Narai died, Constantine Phaulkon was executed, and Phra Petratcha became king. a four- month siege by the Siamese (C) in the French fortress (A) in Bangkok, in 1688.Smithies 2002 Revolution, p.95-96 Desfarges, when he learned of the crisis, started to move his troops to the capital Lopburi at the request of Phaulkon, but then retreated back to Bangkok when he learned of the king's death on July 11, 1688.
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Smithies won the 2001 Albert Lasker Award for Basic Medical Research, jointly with Martin Evans (Cardiff University) and Mario Capecchi (University of Utah), for their work on homologous recombination. He received the Wolf Prize in Medicine, with Capecchi and Ralph L. Brinster, in 2002/3. He won the 2007 Nobel Prize in Physiology or Medicine, jointly with Capecchi and Evans, "for their discoveries of principles for introducing specific gene modifications in mice by the use of embryonic stem cells." His other awards include two Gairdner Foundation International Awards (1990 and 1993), the North Carolina Award for Science (1993),North Carolina Award for Science, 1993 : NC Awards website.
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In 1969, campus food workers of Lenoir Hall went on strike protesting perceived racial injustices that impacted their employment, garnering the support of student groups and members of the University and Chapel Hill community. From the late 1990s and onward, UNC-Chapel Hill expanded rapidly with a 15% increase in total student population to more than 28,000 by 2007. This is accompanied by the construction of new facilities, funded in part by the "Carolina First" fundraising campaign and an endowment that increased fourfold to more than $2 billion within ten years. Professor Oliver Smithies was awarded the Nobel Prize in Medicine in 2007 for his work in genetics.
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This location would give Birstall a great geographical advantage, making it within easy reach of the main thoroughfares of ancient Yorkshire. A Roman tiled mosaic was unearthed at Birstall Smithies, a former early industrial slag smelting site, during excavations in 1965. This and a hoard of Roman coins discovered at the foot of Carr Lane, on what was then Birstall Recreation Ground indicate quite succinctly as to the prehistoric origins of Birstall. These coins, which were discovered in the 18th century, dated from 192 to 268 AD. A quarter of a mile up the hill from Birstall on Leeds Road, there was once a Roman watch tower.
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A description of the visit of Johan Blaer to one of the larger mocambos in 1645 (which had been abandoned) revealed that there were 220 buildings in the community, a church, four smithies, and a council house. Churches were common in Palmares partly because Angolans were frequently Christianized, either from the Portuguese colony or from the Kingdom of Kongo, which was a Christianized country at that time. Others had been converted to Christianity while enslaved. According to the Dutch, they used a local person who knew something of the church as a priest, though they did not think he practiced the religion in its usual form.
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Smithies' absence from the squad during 2010–11 through injury allowed Ian Bennett to become first choice goalkeeper, backed up by fellow veteran Nick Colgan. His injury meant he remained sidelined for the first half of the season, and had to wait until 14 February 2012 to make his first appearance in the 2011–12 campaign. This came in the 1–0 home defeat to Sheffield United, a result which would cost manager Lee Clark his job the following day. This was followed by his first clean sheet of the campaign in Huddersfield's 2–0 home win over Exeter City on 25 February 2012.
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Baird and Jackie had only recently found out who Pedersen was, after being told by journalist Bill Smithies of the Liverpool Echo. Baird was shocked that Pedersen did not look anything like the Stanley or the Lennon family, having pale blue eyes and fair hair. After releasing the book, John Lennon, My Brother—written with Giuliano, and a foreword by McCartney—Baird travelled to New York during 1989 to appear at a Beatlefest convention, and was asked if she could prove she was really Lennon's half-sister. Baird declined, saying she was not going to produce her passport, and the audience would just have to take her word for it.
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Huddersfield's biggest injury doubt was that of goalkeeper Ian Bennett, who injured his hand during the semi-final second leg against Milton Keynes Dons, with Alex Smithies on standby as his replacement. Scott Arfield had recovered from the ankle injury that forced him off in the semi-final first leg and later forced him to miss the home tie. Sheffield United's Kevin McDonald picked up a hamstring injury in their 1–0 win in the semi-final second leg, and missed the final. Richard Cresswell had recovered from an eye infection that caused him to miss the previous match, and looked set to feature in the final.
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The England captain, Smithies, reflected that the response surprised her; "It changed my life completely for about six months ... It lit up women's cricket again." In amongst all the plaudits were a few notes of caution; Lee suggested that "This final illustrated the athleticism of the game and the status to which it can aspire; what is needed now is firmer and more enterprising administration." Former England player Sarah Potter said "Progress has been held back by lack of hard cash and column inches, and buckets of male condescension." England failed to reach another World Cup final until 2009, when they once again beat New Zealand.
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Expensive, imported wallpaper was combined with popular painting into something entirely new, and the stencilled paintings in many places flowed onto walls, ceilings and fireplaces. The amount of well-preserved interiors kept in its original site, is unique in the world. With the farms in Hälsingland also came a large number of out buildings, freely placed outside the courtyard. Grand barns, large log cabins, smithies, breweries, grain storage houses, stables and liveries all give a picture of the system of many outhouses, which by the end of the 19th century was replaced by large multifunctional buildings that housed many functions under the same roof.
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During the Chameleons' early career, the British music press often used terms such as "sonic architects" and "sonic cathedrals" when describing the band, due to their atmospheric sound. Smithies and Fielding provided shimmering guitar riffs, while Lever and Burgess on drums and bass, respectively, gave the band a solid, rhythmic foundation. The Chameleons emerged as Thatcherism was beginning to have its effect on England's former industrial towns, and their music was imbued with a sense of anxiety and a longing for the security of innocence. Burgess's impassioned vocal delivery complemented his lyrics, which touched on the alienation created in many British communities by the decline of manufacturing and industry, and the consequent disruption of social order.
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Usually, the coal camp, like the railroad camp and logging camps, began with temporary storage, housing and dining facilities —tents, shanties, shacks— until more permanent dwellings could be built. Often the first built structures were log cabin storehouses followed closely by kitchens, a lumber mill and smithies, then management offices, housing. Gradually, within a year or so, the camp grew into a community with a variety of housing types including boardinghouses for transients and new hires, all the growing community organized around a Company Store. The company would often give credit in the form of scrip, a form of token money that would discourage workers from purchasing items in stores outside the town.
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Iron, as the major component of steel, is of major importance to mining. Crude steel produced in Sweden in 2017 (4,9 million tons) consisted of 1/3 scrap iron and 2/3 of pig iron made from iron ore. Sweden's iron was important to both Nazi Germany and the Allies of World War II. During the High Middle Ages, Sweden's iron industry followed the "eastern branch" iron production, using bowl furnace methods rather than the open hearth "bloomery" model favored in England. One of the most important Swedish iron products was osmund (also called osmond iron), small pieces made from pig iron, weighing no more than 300 grams, suited to the needs of village smithies.
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Gene knock-in originated as a slight modification of the original knockout technique developed by Martin Evans, Oliver Smithies, and Mario Capecchi. Traditionally, knock-in techniques have relied on homologous recombination to drive targeted gene replacement, although other methods using a transposon-mediated system to insert the target gene have been developed. The use of loxP flanking sites that become excised upon expression of Cre recombinase with gene vectors is an example of this. Embryonic stem cells with the modification of interest are then implanted into a viable blastocyst, which will grow into a mature chimeric mouse with some cells having the original blastocyst cell genetic information and other cells having the modifications introduced to the embryonic stem cells.
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By the late 1940s, new electrophoresis methods were beginning to address some of the shortcomings of the moving boundary electrophoresis of the Tiselius apparatus, which was not capable of completely separating electrophoretically similar compounds. Rather than charged molecules moving freely through solutions, the new methods used solid or gel matrices to separate compounds into discrete and stable bands (zones); in 1950 Tiselius dubbed these methods "zone electrophoresis". Zone electrophoresis found widespread application in biochemistry after Oliver Smithies introduced starch gel as an electrophoretic substrate in 1955. Starch gel (and later polyacrylamide and other gels) enabled the efficient separation of proteins, making it possible with relatively simple technology to analyze complex protein mixtures and identify minute differences in related proteins.
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Smithies' 2010–11 campaign was punctuated by injury, restricting him to just 27 appearances in all competitions throughout the season. His performances, on the occasions he did play, earned him a call up to the England under-21 squad, although he was unable to play – again due to injury. In January 2011, he was linked with a £1.5m move to Aston Villa, after Villa manager Gérard Houllier was said to have been impressed with his performance against Sheffield Wednesday. Further speculation relating to his future at the club followed Huddersfield's 3–0 defeat against Peterborough United in the League One play-off final, and he was linked with a move to Leicester City, along with teammate Lee Peltier.
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From the conquest of Wales onwards the Romans attempted to contain guerrilla resistance in the highland areas by surrounding the mountains with a network of forts and roads in the valleys. Founded around AD 90, Caer Llugwy housed an auxiliary cohort of around 500 men who policed the local population and controlled communications through the Llugwy and neighbouring valleys. There is a possibility that the outpost was also intended to control mining operations in the nearby hills, hence its Welsh name: Bryn-y-Gefeiliau; "Hill of the Smithies". It was drastically altered when a second fort was built in stone over its eastern defenses around AD 120; effectively leaving a western annex of about .
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The gene targeting method in knockout mice uses mouse embryonic stem cells to deliver artificial genetic material (mostly of therapeutic interest), which represses the target gene of the mouse by the principle of homologous recombination. The mouse thereby acts as a working model to understand the effects of a specific mammalian gene. In recognition of their discovery of how homologous recombination can be used to introduce genetic modifications in mice through embryonic stem cells, Mario Capecchi, Martin Evans and Oliver Smithies were awarded the 2007 Nobel Prize for Physiology or Medicine. Advances in gene targeting technologies which hijack the homologous recombination mechanics of cells are now leading to the development of a new wave of more accurate, isogenic human disease models.
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The repoussé copper frieze depicting the Battle of Lepanto. In 1899, the next owner, Sir John Nutting, improved the house greatly spending thousands of pounds. The facade of the house was faced with Portland Stone to harmonise the 18th and 19th century parts of the house. He also remodelled the interior with Italian Carrara marble and decorative plasterwork. A repoussé copper frieze depicting ships and galleons made around 1900 by James Smithies of Manchester, was added to the dining room. In 1903 Sir John Nutting was given the title of the Nutting Baronetcy of St. Helens. He later died in 1918 and the house was auctioned off. In 1925 the Christian Brothers bought the house and used it as their headquarters.
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Maufe was born Edward Muff in Sunny Bank, Ilkley, Yorkshire, on 12 December 1882.In her original 1986 entry on Maufe for the Dictionary of National Biography, Margaret Richardson gave his date of birth as 12 December 1883 and mentions that "Maufe died 12 December 1974, his ninety-first birthday, in the farmhouse he had restored in the late 1920s at Shepherd's Hill, Buxted, Sussex." In her revised 2004 entry, she corrected the date to 12 December 1882 and re-wrote the death passage as "Maufe died on 12 December 1974, his ninety-second birthday, in Uckfield Hospital." He was the second of three children and youngest son of Henry Muff (d.1910) and Maude Alice Muff née Smithies (died 1919).
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She co-founded the Texas Genetics Society in 1974, and in 1981, she became chair of the Department of Cellular and Structural Biology at the University of Texas Health Science Center in San Antonio. She was also the president of the American Society of Human Genetics that year. A few years later, Oliver Smithies and she followed up on her earlier research on globins, and they discovered the different alleles of the HP gene that change how haptoglobins bind to free hemoglobin She received the Distinguished Texas Geneticist Award in 1990, and after her death, it was renamed in her honor. Her last publication, in 1996, was a study of transgenic mouse models of apolipoprotein E (APOE) proteins and Alzheimer's disease.
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There was an absence of aggression and security for settlers on isolated properties. Cowan took an interest in the Gerald Mission, a mission and school being established by the Wesleyan Church for aboriginal children in York by John Smithies. The mission failed and Cowan blamed the loss of students from the mission school to "yearning" or "strong particularity" to their own districts, but also due to high death rates from influenza at the institution.CSR 230, Cowan to Colonial Secretary 3 March 1852. In his 1852 report, he refers to the Native police in York and Beverley as “efficient” and goes on to say: In this report, Cowan also expressed concern for the effect of drunkenness and vice, and new diseases.
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In addition to the fishermen, the water-dependent trades were dependent on the Wiese. However, due to the dynamics of the river and the fact that it was still unconfined to its course in the Middle Ages, it was relatively difficult to use the water power of the Wiese for water mills, saw mills or smithies. With the increasing reclamation of the meadows during the Middle Ages and the growing importance of livestock farming in agriculture, the newly established meadows on the floodplain and their irrigation became an economic factor. To utilise the water of the river, from the Late Middle Ages it was diverted at weirs, known locally as Wuhre, and guided through artificial channels, known locally as Teiche, to the farms and the meadows, using the routes of old river arms.
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1938 American Society for the Control of Cancer poster The ACS' activities include providing grants to researchers, including funding 49 Nobel Laureate researchers; discovering the link between smoking and cancer; and serving one million callers every year through its National Cancer Information Center. The Nobel Prize laureates include James D. Watson, Mario Capecchi, Oliver Smithies, Paul Berg, E. Donnall Thomas, and Walter Gilbert. The American Cancer Society's website contained a chronological listing of specific accomplishments in the fight against cancer in which the ACS had a hand, including the funding of various scientists who went on to discover life-saving cancer treatments, and advocating for increased use of preventative techniques. The organization also runs public health advertising campaigns, and organizes projects such as the Relay For Life and the Great American Smokeout.
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Born in Norwalk, Connecticut, he earned his A.B. degree from Haverford College in biology, was a high school teacher and lab technician for a year, and earned his PhD degree in bacteriology and immunology from Harvard University. He was a postdoc at the University of Wisconsin (with future Nobel laureate Oliver Smithies) before moving to Columbia, Missouri and joining the University of Missouri faculty in 1975. He spent the 1983–1984 academic year at Duke University with Robert Webster where he began the work that led to him being awarded a Nobel Prize. He is best known for phage display, a technique where a specific protein sequence is artificially inserted into the coat protein gene of a bacteriophage, causing the protein to be expressed on the outside of the bacteriophage.
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The Band of Mercy Advocate, established by Thomas Bywater Smithies in England in 1879, printed songs in every issue. Clapp-Itnyre writes that singing filled a crucial void: "to bring language--and aesthetically pleasing language at that --to a population of animals unable to speak in their own defense." Membership was not limited to children and adolescents; adults would hold officer positions and would use the Bands as a forum to discuss animal cruelty issues and how to handle them. An article dated 18 July 1899 in the San Francisco Call about their local Band of Mercy, for example, mentions members reporting on the number of animal cruelty cases that had been reported in the last year (2,379) along with the resulting numbers of prosecutions (195) and convictions (129).
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Edward Norman Dancer FAA (born 29 December 1946, Bundaberg, Queensland, Australia) is an Australian mathematician, specializing in nonlinear analysis. Dancer received in 1969 a Bachelor of Science with Honours (BSc (Hons)) from the Australian National University and in 1972 a PhD from the University of Cambridge with thesis advisor Frank Smithies and thesis Bifurcation in Banach Spaces. As a postdoc Dancer was from 1971 to 1972 at the University of Newcastle-upon-Tyne, UK and from 1972 to 1973 at the Institute of Advanced Studies at the Australian National University. At the University of New England in New South Wales, he was from 1973 to 1975 a lecturer, from 1976 to 1981 a senior lecturer, from 1981 to 1987 an associate professor, and from 1987 to 1993 a full professor.
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Monk Bretton Bygones, October 1993, printed by Yorkshire Web (a division of The Barnsley Chronicle Limited) The Manor House and several other interesting structures on Cross Street and High Street disappeared in the 1960s. Also demolished was Monk Bretton 'Castle', a folly on Burton Bank built by a local priest as a look-out tower or observatory and subsequently used for the lighting of beacons on occasions such as royal events and the end of wars. Only Manor Farm remains, and the oldest structure still standing is a 17th-century barn at the junction of Cross Street and Westgate, belonging to the farm. The village greatly expanded in the 19th and 20th centuries with the building of new housing estates, so that today Monk Bretton more or less merges into nearby Lundwood, Carlton, Athersley and Smithies.
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John Rogers the compiler and editor of the 1537 Matthew Bible Birmingham's first notable literary figure is John Rogers, the compiler and editor of the 1537 Matthew Bible, parts of which he also translates. This is the first complete authorised version of the Bible to be printed in the English language and the most influential of the early English printed Bibles, providing the basis for the later Great Bible and the Authorized King James Version. Rogers' 1548 translation of Philipp Melanchthon's Weighing of the Interim, possibly translated in Deritend, is the first book by a Birmingham man known to have been printed in England. By the early 16th century Birmingham was already a centre of metal working, for example when Henry VIII was making plans to invaded Scotland in 1523 Birmingham smithies supplied bulk orders for bodkin arrowheads for use by his army.
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Recombinant adeno-associated virus (rAAV) based genome engineering is a genome editing platform centered on the use of recombinant rAAV vectors that enables insertion, deletion or substitiution of DNA sequences into the genomes of live mammalian cells. The technique builds on Mario Capecchi and Oliver Smithies' Nobel Prize–winning discovery that homologous recombination (HR), a natural hi-fidelity DNA repair mechanism, can be harnessed to perform precise genome alterations in mice. rAAV mediated genome-editing improves the efficiency of this technique to permit genome engineering in any pre-established and differentiated human cell line, which, in contrast to mouse ES cells, have low rates of HR. The technique has been widely adopted for use in engineering human cell lines to generate isogenic human disease models. It has also been used to optimize bioproducer cell lines for the biomanufacturing of protein vaccines and therapeutics.
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Estimates of mantle primordial heat loss range between 7 and 15 TW, which is calculated as the remainder of heat after removal of core heat flow and bulk-Earth radiogenic heat production from the observed surface heat flow. The early formation of the Earth's dense core could have caused superheating and rapid heat loss, and the heat loss rate would slow once the mantle solidified. Heat flow from the core is necessary for maintaining the convecting outer core and the geodynamo and Earth's magnetic field; therefore primordial heat from the core enabled Earth's atmosphere and thus helped retain Earth's liquid water. Earth's tectonic evolution over time from a molten state at 4.5 Ga, to a single-plate lithosphere, to modern plate tectonics sometime between 3.2 GaPease, V., Percival, J., Smithies, H., Stevens, G., & Van Kranendonk, M. (2008).
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French soldiers in Siam (17th century Siamese painting) A second French embassy was sent to Siam in March 1687,Mission Made Impossible: The Second French Embassy to Siam, 1687, by Michael Smithies, Claude Céberet, Guy Tachard, Simon de La Loubère (2002) Silkworm Books, Thailand organized by Colbert, with Guy Tachard again included. The embassy consisted of a French expeditionary force of 1,361 soldiers, missionaries, envoys and crews aboard five warships, and had the additional duty of returning the embassy of Kosa Pan to Siam. The military wing was led by General Desfarges, and the diplomatic mission by Simon de la Loubère and Claude Céberet du Boullay, a director of the French East India Company. The embassy arrived in Bangkok in October 1687, on the warships Le Gaillard (52 guns), L'oiseau (46 guns), La Loire (24 guns), La Normande and Le Dromadaire.
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Douglas' biographer, Edward Hubbard, estimated that the duke commissioned four churches and chapels, eight large houses, about 15 schools and institutions, about 50 farms (in whole or part), about 300 cottages, lodges, smithies and the like, two cheese factories, two inns, and about 12 commercial buildings (for most of which Douglas was the architect) – and these were just the buildings in the city of Chester and on the Eaton estate. He commissioned G. F. Bodley to rebuild St Mary's Church in his Cheshire estate village of Eccleston, which was completed in 1899, the year of his death. He also spent money on Grosvenor House in London and Cliveden in Buckinghamshire, which he had inherited on the death of his mother-in-law. He built shooting lodges on sporting estates in Sutherland, in Scotland, that he rented from his cousin, the Duke of Sutherland.
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Sir Martin John Evans (born 1 January 1941) is a British biologist who, with Matthew Kaufman, was the first to culture mice embryonic stem cells and cultivate them in a laboratory in 1981. He is also known, along with Mario Capecchi and Oliver Smithies, for his work in the development of the knockout mouse and the related technology of gene targeting, a method of using embryonic stem cells to create specific gene modifications in mice.Stem cell architect is knighted BBC News : Wednesday, 31 December 2003 (subscription required) In 2007, the three shared the Nobel Prize in Physiology or Medicine in recognition of their discovery and contribution to the efforts to develop new treatments for illnesses in humans. He won a major scholarship to Christ's College, Cambridge at a time when advances in genetics were occurring there and became interested in biology and biochemistry.
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St Augustines Church of England, Leyburn The settlement on Canal Creek (a tributary of the Condamine River) had grown from the 1840s to service the colonising settlers following the stock route blazed by the Leslie brothers in 1840 to the southern Darling Downs. Known from 1853 as Leyburn, the first sale of allotments was held in 1857 following the survey of the town earlier that year. By 1872 a state school, an Anglican church, Police Station and Court House, two smithies, three stores, a sawmill and the inevitable three hotels made up the straggling wooden town centre along the road to Warwick. The town was described as "always a sleepy little town ... whose calm was broken by the brief Canal Creek gold-rush in 1871-2 ... clothed in dust raised by the slow passage of teams and flocks through the town".
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Once free of water work commenced on the excavation of the foundations for the main block of the dam. A large gravel filled hole was discovered in the centre channel or "gullet" of the river bed. This gullet which was deep and varied in width from 50 ft to was dug out and filled with a mix of pozzolana (fly ash) and cement under the dam while under the powerhouse Prepakt concrete was used as this reduced demand on the batching plant which was fully occupied supplying concrete for the dam blocks. In July 1954 Downer replaced 20 senior contractor staff that he had inherited with people of this choosing, many from Morrison–Knudsen Co. A significant appointment was that of A. I. Smithies, a very experienced hydro construction engineer from Morrison-Knudsen as construction superintendent.
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Born in Liverpool, Morais was the drummer in the groups Faron's Flamingos and Rory Storm and The Hurricanes, replacing Ringo Starr after he left to join The Beatles.Stuff.co.nz, Jun 16 2013 - Mood music for the meth-lab - Grant Smithies According to Finding The Fourth Beatle by David Bedford and Garry Popper, Morais had been considered as a possible drummer for the Beatles, but Morais was an attraction and they did not want him with all of his showmanship.Finding The Fourth Beatle: The 23 drummers who put the beat behind the Fab Three, By David Bedford, Garry Popper - August 1962: Almost the Fourth Beatle - Trevor Morais Some time later, Morais was a member of Ian Crawford & the Boomerangs. He also tried to form his own group but gave up on the idea when he was invited to join a group called The Song Peddlers which would later be known as The Peddlers.
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As with the 1970s festivals, Deeply Vale hoped to bring together music of all styles, to create new styles and genres and maybe break a few. Since music seems to follow trends set in history by names such as the Beatles, the Kinks, Bob Dylan, the Rolling Stones, the Doors and many others who broke the musical mould of the 1950s and 1960s turning the times into a psychedelic outlook on life. Deeply Vale has been credited as a catalyst for many bands who have formed since the 1970s festivals. Amongst people who claim to have been in the audience and inspired to pursue a musical career include Andy Rourke of The Smiths, David Gedge from the Wedding Present, Dave Fielding, Mark Burgess and Reg Smithies from the Chameleons, Jimi Goodwin from the Doves, Boff Whalley from Chumbawamba Steve Cowen from the Mock Turtles and Ian Brown from the Stone Roses.
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Title page of a 1902 edition of Paul Pelliot's translation Mémoires sur les coutumes du Cambodge de Tcheou Ta-Kouan Zhou's account was first translated into French in 1819 by Jean-Pierre Abel-Rémusat but it did not have much impact.Jean-Pierre Abel-Rémusat: Description du royaume de Cambodge par un voyageur chinois qui a visité cette contrée à la fin du XIII siècle, précédée d'une notice chronologique sur ce même pays, extraite des annales de la Chine, Imprimerie de J. Smith, 1819 It was then retranslated into French by Paul Pelliot in 1902, and this translation was later partly revised by Pelliot and republished posthumously in 1951. Pelliot however died before he could complete the comprehensive notes he had planned for Zhou's work. Pelliot's translation is highly regarded and it formed the basis of many later translations into other languages, for example the English translations by J. Gilman d’Arcy Paul in 1967 and Michael Smithies in 2001.
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During the 19th century, mathematicians started to formalize all the different branches of mathematics. One of the first to do so was Cauchy; his somewhat imprecise results were later made completely rigorous by Weierstrass, who advocated building calculus on arithmetic rather than on geometry, which favoured Euler's definition over Leibniz's (see arithmetization of analysis). According to Smithies, Cauchy thought of functions as being defined by equations involving real or complex numbers, and tacitly assumed they were continuous: :Cauchy makes some general remarks about functions in Chapter I, Section 1 of his Analyse algébrique (1821). From what he says there, it is clear that he normally regards a function as being defined by an analytic expression (if it is explicit) or by an equation or a system of equations (if it is implicit); where he differs from his predecessors is that he is prepared to consider the possibility that a function may be defined only for a restricted range of the independent variable.
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This has included the many complications inherent in stem cell transplantation (almost 200 allogeneic marrow transplants were performed in humans, with no long-term successes before the first successful treatment was made), through to more modern problems, such as how many cells are sufficient for engraftment of various types of hematopoietic stem cell transplants, whether older patients should undergo transplant therapy, and the role of irradiation-based therapies in preparation for transplantation. The discovery of adult stem cells led scientists to develop an interest in the role of embryonic stem cells, and in separate studies in 1981 Gail Martin and Martin Evans derived pluripotent stem cells from the embryos of mice for the first time. This paved the way for Mario Capecchi, Martin Evans, and Oliver Smithies to create the first knockout mouse, ushering in a whole new era of research on human disease. In 1995 adult stem cell research with human use was patented (US PTO with effect from 1995).
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The Ginninderra blacksmith’s shop is one of the most significant historical sites of the Australian Capital Territory. It was one of the first sites to be listed on the ACT Interim Heritage Places Register in 1993. The workshop is also of national importance as it is one of only a few known surviving stand- alone blacksmith shops in Australia; although, many farm-based smithies have survived. The building remains in stable condition, but there is no firm plan concerning its long-term management and it remains fenced-off and innaccessible to the public.P. Saunders, A European Cultural Resource Survey of Ginninderra Village and ‘Deasland’ Woolshed, Harcourt Hill Development Area, Gungahlin, ACT: Final Report, Canberra, 1993, pp. 20-23; cf. L. Bordiss, ‘The Ginninderra Blacksmith’s Workshop: a Heritage Study of the Tools Used by Henry Roland Curran’. Conservation study prepared for the University of Canberra, 2003, passim; J. McDonald, Three Henry Currans, Canberra, 2018, pp. 289-305.
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The Hill House estate was laid out in the 1780s by a Mr Brown. Perhaps the greatest change of all came as a result of the enclosure award of 1799 when Lynch Green was divided up and disappeared as an open space, although the tithe map shows that there were still only a few houses along Mill Road and Great Melton Road in 1844. In Victorian Miniature, Owen Chadwick gives us a detailed account of life in the area in the middle of the 19th century. The Rev William Waite Andrew, the Vicar of Ketteringham and one of the two central characters in the book, lived at Woodhall which he bought for £3,600 in 1841, and to which he added a new western extension. In the 19th century, village crafts and small industries employed a number of men locally; two windmills existed, one giving the name to Mill Road. Three smithies existed in the village in the 1880s and carriages were built at Harveys.
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Retrieved on 23 January 2008. the Alfred P. Sloan, Jr. Prize from the General Motors Foundation, jointly with Capecchi (1994), the Ciba Award from the American Heart Foundation (1996), the Bristol Myers Squibb Award (1997), the Association of American Medical Colleges' Award for Distinguished Research, jointly with Capecchi (1998), the International Okamoto Award from the Japan Vascular Disease Research Foundation (2000), the O. Max Gardner Award, the highest award for faculty in the University of North Carolina system (2002), the Massry Prize of the Meira and Shaul G. Massry Foundation (2002), shared with Capecchi, the March of Dimes Prize in Developmental Biology, jointly with Capecchi (2005), and the American Institute of Chemists Gold Medal (2009). Smithies was elected to the United States National Academy of Sciences (1971), the American Academy of Arts and Sciences (1978), the American Association for the Advancement of Science (1986), the Institute of Medicine (2003), and as a foreign member of the Royal Society (ForMemRS; 1998). He received honorary degrees from the University of Chicago (1991), the University of São Paulo (2008) and the University of Oxford (2011).
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He celebrated the occasion by striking the earliest papal coin, and in a mark of the direction the mediaeval papacy was to take, no longer dated his documents by the Emperor in the east, but by the reign of Charles, king of the Franks. A mark of such newly settled conditions in the Duchy of Rome is the Domusculta Capracorum, the central Roman villa that Adrian assembled from a nucleus of his inherited estates and acquisitions from neighbors in the countryside north of Veii. The villa is documented in Liber Pontificalis, but its site was not rediscovered until the 1960s, when excavations revealed the structures on a gently-rounded hill that was only marginally capable of self-defense, but fully self-sufficient for a mixed economy of grains and vineyards, olives, vegetable gardens and piggery with its own grain mill, smithies and tile-kilns. During the 10th century villages were carved out of Adrian's Capracorum estate: Campagnano, mentioned first in 1076; Formello, mentioned in 1027; Mazzano, mentioned in 945; and Stabia (modern Faleria), mentioned in 998.
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When first completed, several northern ascents were far too steep for conversion into a wagon road so required later expensive engineering works by building shoulders into slope traversing roadbeds. Inspired by the earlier Lehigh & Susquehanna Turnpike, the two toll roads connected Philadelphia and New Jersey (Delaware & Lehigh Valley communities) to Lake Erie at Buffalo, New York via the toll bridge across the Susquehanna River between Berwick and Nescopeck—the northern terminus of the Lausanne-Nescopeck Turnpike. After the War of 1812, much of Berwick's post war growth and industrial development was because it was one of the first towns with foundries, mills and smithies that could be regularly supplied by the new wonder fuel, Anthracite coming from across the river via the Nescopeck river port from the modest mines at Jeddo, Pennsylvania. Between Nescopeck and Lausanne Landing, the Lehigh & Susquehanna Turnpike passed through the future Beaver Meadows settlement near the Jeddo works (& lands) that were the predecessor to, and inspiration of the industrial pioneers of the Beaver Meadow Railroad and Coal Company.
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Phra Maha Chedi Si Ratchakan Wat Pho is one of Bangkok's oldest temples. It existed before Bangkok was established as the capital by King Rama I. It was originally named Wat Photaram or Podharam, from which the name Wat Pho is derived. The name refers to the monastery of the Bodhi tree in Bodh Gaya, India where Buddha is believed to have attained enlightenment. The date of the construction of the old temple and its founder are unknown, but it is thought to have been built or expanded during the reign of King Phetracha (1688–1703). The southern section of Wat Pho used to be occupied by part of a French Star fort that was demolished by King Phetracha after the 1688 Siege of Bangkok.Jean Vollant des Verquains History of the revolution in Siam in the year 1688, in Smithies 2002, p.95-96 After the fall of Ayutthaya in 1767 to the Burmese, King Taksin moved the capital to Thonburi where he located his palace beside Wat Arun on the opposite side of the Chao Phraya River from Wat Pho. The proximity of Wat Pho to this royal palace elevated it to the status of a wat luang ('royal monastery').
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Before heading out, Zu Ti stated his intentions to Sima Rui first. Although Sima Rui permitted him to carry out an expedition, he was not too enthusiastic about it as he was more concerned with developing Jianye. Sima Rui appointed Zu Ti as Inspector of Yuzhou and General Who Exerts Might while also providing food and clothes but did not provide him with any weapons nor armor, and recruits had to be done by Zu himself.(時帝方拓定江南，未遑北伐，逖進說曰："晉室之亂，非上無道而下怨叛也。由藩王爭權，自相誅滅，遂使戎狄乘隙，毒流中原。今遺黎既被殘酷，人有奮擊之志。大王誠能發威命將，使若逖等為之統主，則郡國豪傑必因風向赴，沈弱之士欣於來蘇，庶幾國恥可雪，願大王圖之。"帝乃以逖為奮威將軍、豫州刺史，給千人稟，布三千匹，不給鎧仗，使自招募。) Book of Jin, Volume 62 Regardless, Zu Ti crossed the Yangtze and landed in Huaiyin county in 313, where he built smithies and foundries to have his soldiers produce their own weapon.
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