In this most recent study, many participants relapsed within a month and the vast majority of participants relapsed before the six-month follow-up.
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"I was diagnosed at 15, I relapsed at 19 and a month short of my 21st birthday and I have relapsed now at 23," he said.
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Over the next year, Jason relapsed, went into remission again, relapsed and, all the while, suffered an accumulation of medical trials caused by his prolonged exposure to chemotherapy and radiation.
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I mourned, I keened, I ultimately relapsed after he died.
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We joke to this day how I "relapsed" on glögg.
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She relapsed when Unglert was 14, and died shortly after.
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He relapsed, began drinking heavily again, and his depression worsened.
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Unfortunately, late yesterday, I was informed that Lindsay had relapsed.
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I got out and relapsed shortly after (maybe a week?).
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After only 28 days of rehab in 2011, I relapsed.
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If she relapsed, she could be sent directly to prison.
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Bam agreed ... but relapsed after a few days in treatment.
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When her daughter was 4 she relapsed and lost custody.
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Then she relapsed and snorted her drug of choice — fentanyl.
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She remained sober during her pregnancy, but relapsed soon after.
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Despite many stints in rehab, Nic had recovered and relapsed, recovered and relapsed, over and over, all while his parents (who split up when he was young) alternately watched helplessly and tried to intervene.
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Sadly, Liam also relapsed for the first time that same year.
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Shoptaw said that if Lovato has relapsed, it wouldn't be unexpected.
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Oscar relapsed this week and was arrested for DUI in Pasadena.
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The first real problem comes up with Wanda, who has relapsed.
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A year ago, she went to rehab in Florida, but relapsed.
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After a period of rehabilitation, she relapsed in 2015, losing $230,000.
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I knew that if I relapsed again, I would surely die.
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Mike Braun of Indiana, learned that her Hodgkin's lymphoma had relapsed.
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He tried several recovery programs but relapsed and overdosed several times.
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Jones, though, lost his job when he relapsed soon after graduation.
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He relapsed immediately — he just started driving back to buy his drugs.
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But he relapsed, and he hasn't played on a soccer field since.
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It only treats ALL patients up to age 25 who have relapsed.
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But some have relapsed, and we don't know the long-term effects.
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Kleber said up to 90% of them relapsed shortly after their release.
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Perhaps that meant he never really did, or had and then relapsed.
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Then I relapsed again in 2015 at a strip club in Montreal.
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My family helped fund rehab but I relapsed before I'd even left.
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Soon he relapsed, and after months of secret drug use, he overdosed.
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He began to use immunological therapy to treat relapsed, refractory Hodgkin's lymphoma.
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I spoke with others who improved for a while but then relapsed.
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Despite multiple efforts to get his addiction under control, he repeatedly relapsed.
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I decided to go to an outpatient program but then relapsed again.
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Some of the women Runyon has hired have relapsed into using drugs.
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During the filming of the HBO series "The Night Of," he relapsed.
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In March, Mia revealed that she relapsed after three decades of sobriety.
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Months after first getting clean, and while writing the book, Barrymore relapsed.
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By then, Mr. Jarrell, who had also relapsed, was back in jail.
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An acquaintance testified she wanted to get off crack, but had relapsed.
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However, in June, she hinted that she had relapsed in a new single.
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The truth is this: I relapsed, I surrendered and I am getting help.
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About two weeks after my abortion, still suffering from "retained products," I relapsed.
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She relapsed once after leaving but hasn't had a drink since March 2017.
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"I had friends who went to rehab and they all relapsed," he said.
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She says she's been clean since March, when she relapsed after another miscarriage.
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A car needs a tune-up, a relapsed addict needs a complete overhaul.
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Some of Miller's fans blamed Grande when he relapsed after they broke up.
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But in January 2016, she relapsed and was put on a clinical trial.
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After nearly a year of recovery, though, Kat missed her shot and relapsed.
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It went well for three months, but then I relapsed in the summer.
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" In June, Lovato shared that she had relapsed and released the single "Sober.
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Jennifer has been through treatment dozens of times, but she's always relapsed afterward.
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He relapsed after two years of sobriety and eventually died on the street.
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Some of the people she met at the center relapsed and are now dead.
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Things started to look up, but Beau relapsed during his first year at university.
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Amber Portwood's arrest doesn't mean she's relapsed, a source close to her tells PEOPLE.
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However, in a single released last month, titled "Sober," Lovato said she had relapsed.
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Heroin, crack, psychedelics, you name it, he took it and relapsed with a bang.
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The drug secured approval for relapsed or refractory AML patients with an IDH210 mutation.
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At the time of her death, Deven was recently sober, but then she relapsed.
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The drug was being tested in adult patients with a type of relapsed leukemia.
|
|
Unfortunately, she relapsed and began to struggle with the cycle of bulimia once again.
|
|
But, Xan now tells TMZ he relapsed on pain killers -- specifically Xanax and hydrocodone.
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|
For decades, he explained, oncologists had treated relapsed Hodgkin's lymphoma in a standard manner.
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|
Many had already been treated with T-cells directed at CD19 and had relapsed.
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He relapsed just days before jumping, after 11 months of sobriety, his longest stretch.
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He was in detox and rehab more than a dozen times and always relapsed.
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He said that she had told him she'd relapsed on meth earlier that fall.
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When he relapsed again, he could not afford to keep traveling to MD Anderson.
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Of those who graduated in April, about a third are believed to have relapsed.
|
|
Maybe they were waiting to see if she relapsed when Mr. Jarrell was released.
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|
When I relapsed, and you shamed me for it—you contributed to my addiction.
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|
"If I tried doing it on my own, I would have relapsed," Casey told me.
|
|
The trial included adult patients with either relapsed or refractory B cell acute lymphoblastic leukemia.
|
|
After a few months in which she struggled to get follow-up care, Erin relapsed.
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|
After being discharged from Mountainside, they both did what addicts do best and ultimately relapsed.
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|
In February, reports began circulating that Lovato had relapsed and re-entered a treatment facility.
|
|
But after three years, Alessandro relapsed and went back to taking cocaine nearly every day.
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"The people who are using this have relapsed several times" on other therapies, Sehgal adds.
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|
In February, reports began circulating that Lovato had relapsed and re-entered a treatment facility.
|
|
David Cassidy is slamming rumors that he has relapsed in his battle with alcohol abuse.
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|
The on May 25, Baier confessed to PEOPLE that he had relapsed on prescription pills.
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|
Ten years later, when I was 215, she relapsed and put herself into heart failure.
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|
"My mom was my main supporter, but also the one I relapsed with," Warrior said.
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|
Gooden has denied having relapsed and has questioned Strawberry's exhorting him publicly to seek help.
|
|
But Becky relapsed before what was to be their final major, Tokyo in February 2014.
|
|
When her best friend's cancer relapsed, Victoria Redel was willing to do anything to help.
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The drug, JCAR015, was being tested in adult patients with a type of relapsed leukemia.
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|
She drank more and more, awakened her cravings for the stronger high of heroin, and relapsed.
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|
JCAR015 is intended to be used to treat patients with relapsed or refractory acute lymphoblastic leukemia.
|
|
But like so many who struggle with addiction, Hockett relapsed again, this time in early April.
|
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Tuesday's hospitalization comes four weeks after Lovato revealed she had relapsed after six years of sobriety.
|
|
Demi Lovato was back on stage Thursday night, a day after revealing she had recently relapsed.
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|
After showcasing so much teamwork throughout the playoffs, the Thunder relapsed and settled for isolation sets.
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|
The boy, who was in recovery, has relapsed into drug use and is not seeing her.
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I also visited Kieonee Brown, who had relapsed after testifying at the trial of her rapist.
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He tells Ramon that he left in the middle of the night because his friend relapsed.
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|
Only now, a year later, she admitted that even in the first months there, she relapsed.
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ASSHOLES The title refers to two relapsed addicts who meet cute in a therapist's waiting room.
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Although 40 percent relapsed during the 12-week trial, nearly two-thirds of younger patients did.
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|
She relapsed, however, revealing the news in the song "Sober," which was released in June 2018.
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|
All have been hospitalized, and several have relapsed and needed to be readmitted, according to the IDPH.
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Lovato relapsed after she left the treatment center, then entered a sober living facility for a year.
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|
He became isolated and soon relapsed, stopped his medication and let his new accommodation fall into chaos.
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|
She relapsed after she left the treatment center, then entered a sober living facility for a year.
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Lovato relapsed after she left the treatment center, then entered a sober living facility for a year.
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|
She's still in pain, but said she hasn't relapsed in almost four years since she got clean.
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|
A 35-year-old woman from New York with relapsed lymphoma saw her bulky nodes melt away.
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|
Initially when she started treatment with counseling and drug substitution she relapsed and would still use cocaine.
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|
Lovato's hospitalization also comes four weeks after she revealed she had relapsed after six years of sobriety.
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|
Instead, he relapsed and left the family, only to reconnect with Beck while she was at Brown.
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|
In my case, for example, I never relapsed during the time when I had active withdrawal symptoms.
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|
I've lost count, but I think [my brother] overdosed five times and relapsed half a dozen times.
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|
Five years later, 22019 percent of the people who achieved remission had relapsed, the study also found.
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|
He added that with opioids, 60 to 80 percent have relapsed to some extent within six months.
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|
SANOFI SA: Sanofi said on Monday FDA approved Sarclisa® for patients with relapsed refractory multiple myeloma.
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Lovato indicated in a new song released last month that she relapsed after six years of sobriety.
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|
And a newly single Kevin, who relapsed, looks to further his career with a new movie role.
|
|
The new research involved patients with relapsed or refractory AML who tested positive for the FLT20003 mutation.
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|
Besponsa was approved to treat adults with relapsed or refractory B-cell precursor acute lymphoblastic leukemia (ALL).
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|
By late November 2016, 11 of the 52 patients in the study who went into remission relapsed.
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|
Then he relapsed — as is common among people struggling with addiction, especially when they get off medication.
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|
In fact, though she managed to stay sober for several months on her own, she eventually relapsed.
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|
Three years after delivery, 40% of patients with anorexia and 70% of patients with bulimia had relapsed.
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|
Olivia Stoy discovered in March her cancer had relapsed and needs the transplant no later than July, WSVN.
|
|
In 2013, the rock singer relapsed and apologized to his wife and their kids via a Facebook message.
|
|
Guzman also claims in legal docs she's worried Chris is abusing drugs and has relapsed ... especially with sizzurp.
|
|
"Food is still the biggest challenge in my life," she said, explaining she had recently relapsed and purged.
|
|
In her new single "Sober," Lovato shared with fans that she had relapsed after six years of sobriety.
|
|
Anyway ... it's the first time we've seen Ben on the set since he relapsed nearly 2 weeks ago.
|
|
When she left rehab for the first time last year, she said she moved home — and immediately relapsed.
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|
Its cross-audience appeal, uniting clubgoers and relapsed emo kids, is a result of its alloy-like construction.
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|
The Phase 1 clinical study demonstrated encouraging results in treating patients with late-stage relapsed-refractory multiple myeloma.
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|
But with regular drug testing, only one out of 23 of those hired have relapsed, Ms. Bosch said.
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She enrolled in rehabilitation programs several times for cocaine and heroin addiction since 2012, but relapsed each time.
|
|
Spain's Oryzon Genomics said on Monday its Iadademstat compound showed efficacy signs in relapsed small cell lung cancer.
|
|
Companies therefore must compete for the few patients with relapsed melanoma who are at centers offering clinical trials.
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|
"He had a breakdown, and he relapsed again," Carl Jackson, who said he is Kennon's uncle, told ABC 7.
|
|
Madison tells Kate that she struggled with her eating disorder in middle school and relapsed a few weeks ago.
|
|
McGrath was first diagnosed in July 2013 with High-Risk Childhood Acute Lymphoblastic Leukemia, and relapsed in May 2015.
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|
They wanted me to have surgery in case it relapsed, but I didn't want to discuss anything with them.
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|
On top of all that, after Michael's grandmother died, his grief-stricken father, who was a recovering addict, relapsed.
|
|
The trial, dubbed the "ROCKET" trial, focuses on adult patients with relapsed or refractory B cell acute lymphoblastic leukemia.
|
|
" And despite the fact that Odom has relapsed in the past, Stork says the former athlete "seems very committed.
|
|
A week after revealing she relapsed after six years of sobriety, Lovato took to Instagram to express her gratitude.
|
|
So, I'm recommending some newer shows (compared to the classics loved by relapsed fans) as entry points for newcomers.
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|
But I eventually relapsed, and when I did, it was on a less readily visible area: my bikini line.
|
|
A heroin addict who's detoxed, rehabbed and relapsed more than once, he's high again, with a toddler in tow.
|
|
I had chemotherapy and a transplant that year but relapsed twice, leading to my fourth transplant eight years ago.
|
|
The drug, Idhifa, secured approval for relapsed or refractory AML patients who have an IDH2 mutation, the FDA said.
|
|
The company said it received FDA approval to treat adult patients with relapsed or refractory large B-cell lymphoma.
|
|
Lucaz sought help for his addiction at a high-end 240-step rehab in Florida, but relapsed soon after.
|
|
According to the magazine, Hunter first relapsed in November 2662, after seven years of sobriety, and then again in 2013.
|
|
They publicly discussed their shared history of sexual abuse in the show's second season, and not long afterward, Haim relapsed.
|
|
Meyers has sought treatment for alcoholism in the past, most recently having relapsed in September 2017 following his wife's miscarriage.
|
|
Almost a month after revealing she had relapsed, the pop star, 21, was hospitalized following an overdose on July 2800.
|
|
Jack Wagner spent hours talking with fans about addiction struggles after his son relapsed and disappeared for nearly a week.
|
|
Teen Mom OG star Tyler Baltierra revealed that his father, Butch Baltierra, has relapsed after recently completing a rehab program.
|
|
Last month, Lovato revealed in a new emotional single that she had relapsed months after celebrating six years of sobriety.
|
|
Demi Lovato is "a new person with a new life" after revealing in her latest single that she recently relapsed.
|
|
S) tisagenlecleucel for treating B-cell acute lymphoblastic leukemia (ALL) in children and young adults who relapsed or failed chemotherapy.
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|
Kite has also reported data showing remission in 73 percent of 11 patients with relapsed ALL treated with axi-cel.
|
|
The DREAMM-1 study of patients with relapsed/refractory multiple myeloma confirmed the potential effectiveness of the medicine, GSK said.
|
|
It's been tested in patients whose leukemia has relapsed in spite of the best chemotherapy or a bone-marrow transplant.
|
|
Wendy said Terry being on suboxone is a relief since it can dull the effects of opioids if he relapsed.
|
|
They kept hoping I would just somehow stop, even though every time I tried to quit, I relapsed within months.
|
|
Falchi and O'Connor will use this small "training set" to begin a miniature trial of patients with relapsed Hodgkin's disease.
|
|
According to the magazine, Hunter first relapsed in November 2010, after seven years of sobriety, and then again in 2013.
|
|
Lovato released a single in June called, "Sober," in which she revealed she had relapsed after six years of sobriety.
|
|
At first, Stephanie was frustrated by her brother's addiction—while Harris did several stints in rehab, he relapsed each time.
|
|
Lovato released a single in June called, "Sober" in which she revealed she had relapsed after six years of sobriety.
|
|
Fda grants priority review for daratumumab in relapsed multiple myeloma * Sbla was submitted by genmab's licensing partner, janssen biotech, inc.
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|
Shortly afterward, she relapsed and, she said, returned to her doctor for help, asking for a stronger dose of Suboxone.
|
|
At about that same time, Strawberry said he feared Gooden that had relapsed and that his life was in danger.
|
|
Jobs stepped down as Apple CEO on August 24, 2011, accepting a role as chairman, after his pancreatic cancer relapsed.
|
|
She relapsed while I was at work, and my 3-year-old daughter was home alone with her for two hours.
|
|
The trial involved adult patients with relapsed or refractory B cell acute lymphoblastic leukemia, and was known as the "ROCKET" trial.
|
|
Battling drug addiction, her son had relapsed a number of times, and Packer held out hope this time would be different.
|
|
But when he relapsed again, she says they decided to be honest with their children when they visited him at rehab.
|
|
Despite reports Lovato relapsed last month, a source close to the singer, 26, tells PEOPLE exclusively the rumors are not true.
|
|
But when he relapsed again, she said they decided to be honest with their children when they visited him at rehab.
|
|
It appears Demi Lovato has relapsed after 6 years of sobriety ... at least based on the lyrics in her new single.
|
|
Ashley made it to rehab but relapsed, and Brent spent time in and out of prison for dealing and possessing drugs.
|
|
The clerics argued that she had never relapsed and that her survival in first remission was rare but not impossibly so.
|
|
She said at the Time 100 Health Summit she's "so proud of it" she doesn't want anyone to think she's relapsed.
|
|
She was Australian junkie royalty who'd been abstinent from drugs for a decade, relapsed briefly, and was now nine months clean.
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|
Unfortunately, my partner back in California, who suffers from depression and is a recovering alcoholic, relapsed and tried to kill himself.
|
|
Both went to rehab and relapsed; both suffered drug-induced psychosis — N. from crystal methamphetamine, M. from meth and crack cocaine.
|
|
Mr. Avitto, who had a history of drug abuse, had just been released to a treatment center and almost immediately relapsed.
|
|
But on that bright evening, as the man lambasted us on the street corner, I relapsed and pulled my wife away.
|
|
He added the names of everyone he encountered to a spreadsheet, and he kept in touch even with those who relapsed.
|
|
Welcomed at first as a stabilizing force, the Marines began to come under attack as the fragile nation relapsed into chaos.
|
|
Trump soon relapsed to dipping his head toward his microphone and bellowing "wrong" whenever he felt Clinton was misstating his record.
|
|
"They go for many years, and they've relapsed over and over again, and they have the highest risk of dying," says Kaye.
|
|
"Food is still the biggest challenge in my life," she said, explaining she had relapsed and purged as recent as early 2017.
|
|
Demi Lovato Fights Back Tears Performing &aposSober&apos After Reported Relapse -- Watch "Demi relapsed and started drinking alcohol again," the source said.
|
|
The high school freshman relapsed this summer, and the WonderSphere was a bright spot during a long two months as an inpatient.
|
|
Lovato celebrated six years of sobriety in March of this year, but admitted in her new song "Sober" that she had relapsed.
|
|
Amgen said the agency approved Kyprolis in combination with dexamethasone or with the drug lenalidomide plus dexamethasone for relapsed or refractory patients.
|
|
It approved the drug as a single agent for patients with relapsed or refractory disease who have received one or more treatments.
|
|
In my iPhone, I find a note from 2015, not long after I first relapsed after being abstinent for a few years.
|
|
Yet even though many men and women with relapsed Hodgkin's lymphoma responded to immunological treatments, there were some who remained deeply resistant.
|
|
Though Mr. Miller relapsed this summer, he is now in a sober living center, his mother, Cyndi, said in a recent interview.
|
|
A rehab program worked once before, but a year later she relapsed, which led to her current life, homeless for two years.
|
|
Data from Kite showed remission in 73 percent of 11 patients with relapsed ALL who took its CAR-T treatment axi-cel.
|
|
Rue just relapsed, Maddy's seen the tape, and there's no way that Fez's robbery-gone-wrong could result in a positive outcome.
|
|
Despite their ups and downs over the years, Bethenny Frankel was by Luann de Lesseps' side when she relapsed, helping stage an intervention.
|
|
She says he hadn't relapsed since 2009, but now she wonders how she could have missed clues that he was in trouble again.
|
|
I had spent six or seven years on and off Antabuse treatments, but when my girlfriend at the time left me, I relapsed.
|
|
Arizona State (212-212, 3-2) relapsed on defense after consecutive strong showings, missing tackles and assignments while giving up multiple big plays.
|
|
The "Tell Me You Love Me" singer, 26, had lived a sober life for more than six years before she relapsed last year.
|
|
"I have many people in my practice, whether they're high-profile or not, that have been in recovery but they've relapsed," Samuels says.
|
|
The new pictures come just weeks after Lovato candidly revealed through an emotional new song that she relapsed after six years of sobriety.
|
|
The U.S. Food and Drug Administration has already approved Kyprolis for patients with relapsed or refractory multiple myeloma who have previously undergone treatment.
|
|
A few months after she moved away from my father, my mother relapsed in that same apartment that was meant to save her.
|
|
Celgene is working on an experimental new gene therapy designed to treat people with relapsed or refractory aggressive B-cell non-Hodgkin lymphoma.
|
|
And in that city, the number of new virus deaths and confirmed cases is still growing, with even some reports of relapsed cases.
|
|
The finale of HBO's "Euphoria" surprised viewers when the show's main character, Rue, relapsed right before being propelled into an emotional musical number.
|
|
When she relapsed, Eldred returned to her doctor, who determined her opioid maintenance medication dose was too low, and raised it, she recalled.
|
|
Another study in January found that patients relapsed half as often using Ocrevus than they did using a more costly drug on the market.
|
|
Yaghoubi has gone into remission and relapsed again — now her doctors tell her she is on her way to being 100 percent cancer-free.
|
|
According to the latest figures from the World Health Organization, there were 1.193,320 reports of new and relapsed TB cases in Argentina last year.
|
|
The combo was approved for adults, who have received at least two prior therapies for relapsed or refractory form of non-Hodgkin's lymphoma (NHL).
|
|
"My dad, he's relapsed," Tyler, 27, told Teen Mom alum Kail Lowry and Chrisley Knows Best star Lindsie Chrisley on their podcast Coffee Convos.
|
|
The treatment, Xospata, was approved for patients with acute myeloid leukemia (AML) with a FLT3 mutation, whose cancer has relapsed or proved treatment-resistant.
|
|
Although Deven has battled addiction for many years, she was recently sober, but relapsed last Friday, Jonathan alleged in the documents, the outlet reports.
|
|
A clinical trial showed that 83 percent of patients who had relapsed or failed chemotherapy achieved complete or partial remission three months post infusion.
|
|
Patients with a 17p deletion account for about 10 percent of those with untreated CLL and about 20 percent of those with relapsed CLL.
|
|
After Linsenmeir relapsed and lost custody of her son, her disease "brought her to places of incredible darkness," her sister wrote in the obituary.
|
|
In that trial, Janssen reported that only about one-quarter of subjects relapsed, compared to 2540 percent of subjects who received the placebo spray.
|
|
The restaurant industry has struggled with weak sales and traffic throughout 2016 and chains are developing ways to lure in new, relapsed and current customers.
|
|
"If I'm being honest, if I hadn't come out about my eating disorder when I did, I probably would have relapsed," Amelia told the outlet.
|
|
"If I'm being honest, if I hadn't come out about my eating disorder when I did, I probably would have relapsed," Amelia, 18, told Glamour.
|
|
The combo is used to treat adults, who have received at least two prior therapies for relapsed or refractory form of non-Hodgkin's lymphoma (NHL).
|
|
Kyprolis has already been approved by the U.S. Food and Drug Administration for patients with relapsed or refractory multiple myeloma, who have previously been treated.
|
|
That company published nine articles and had one highly cited paper for a very early study of a potential treatment for relapsed chronic lymphocytic leukemia.
|
|
She had broken the curfew imposed on her by a drug court and relapsed with the opioid pills she'd been hooked on for six years.
|
|
Moore writes that after more than two decades of being sober, she relapsed into alcohol and drug abuse during her marriage with Ashton Kutcher, 41.
|
|
To suppress her cravings and withdrawal symptoms, a doctor gave her a prescription for Suboxone, a drug used to treat opioid addiction, but she relapsed.
|
|
Offenburger later testified that she thought Baker had finally put his drug use behind him for good, and that she didn't know he had relapsed.
|
|
Yet he recently "relapsed," as he put it, when one of his closest friends from college posted something on Facebook about Trump's alleged Russia ties.
|
|
When she went back to New York, she relapsed again; this time, she committed crimes, including fraud and robbery, to get money to buy drugs.
|
|
She relapsed one afternoon in April after finding an old bag of heroin in her garage, but being on Suboxone, she felt sick, not high.
|
|
He served six years in prison but relapsed upon his release and spent two years homeless, wandering the streets in search of his next fix.
|
|
Juno's drug is being evaluated in adults with relapsed or refractory B-cell acute lymphoblastic leukemia, a type of blood cancer with a very poor prognosis.
|
|
" Carl Jackson, who said he is Kennon's uncle, told local news station ABC 7 after the incident that Kennon "had a breakdown, and he relapsed again.
|
|
So when Erin's leukemia returned in February of 217, and she relapsed again in March 2012, Erin could get her life-saving (and extremely costly) treatments.
|
|
"These places were holding barns for kids to wait 'til they relapsed," he said of sober living homes that allegedly make shady deals with treatment centers.
|
|
The agency also approved the drug as a single agent for patients with relapsed or refractory multiple myeloma who have received one or more previous treatments.
|
|
Nine-year-old Bailey Cooper had just relapsed from cancer for the second time in 2017 when he learned that his mother, Rachel Cooper, was pregnant.
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"I came back in tonight because I had relapsed, and it was going to be a problem if I didn't do something about it," he said.
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He relapsed four years later while working at a West Virginia hospital and underwent treatment and monitoring by a state program for doctors with addiction problems.
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The study, ASPIRE, tested Kyprolis, chemically known as carfilzomib, in multiple myeloma patients whose cancer had relapsed following prior treatment or did not respond to treatment.
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She also struggled with alcohol and drug addictions, and revealed to her fans she had relapsed in her song "Sober" which was released in June 2018.
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"Depp is an alcoholic and drug addict, and these violent episodes occurred mostly after Depp had relapsed into a cycle of substance abuse," the documents read.
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An article published that year in The New England Journal of Medicine reported the drug's remarkable effect on relapsed Hodgkin's patients, albeit in just 27 people.
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Last March, Lovato revealed she celebrated six years of sobriety, but in June she released a new song, "Sober" on which she revealed that she had relapsed.
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And her health scare comes one month after she revealed in her song "Sober" that she had relapsed, just three months after celebrating six years of sobriety.
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She penned a song called "Sober," in which she admitted to her fans that she had relapsed, but De La Garza is still unsure what triggered it.
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By the time he's done helping someone in need back on their feet, they've already relapsed and returned to living on the street before he can return.
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"We've never seen this theoretical thing," Brody said, arguing that the chance of any adverse event happening is certainly smaller than the certain death of relapsed cancer.
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Shortly after voluntarily leaving the center, the star relapsed and then entered a sober living facility at her team's urging, in which she stayed for a year.
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AstraZeneca said Lynparza, the company's cancer drug being jointly developed with Merck & Co, improved response rates in patients with a form of relapsed ovarian cancer after chemotherapy.
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Mr. El Bahnasawy — whose lawyers wrote that he had a long history of drug use, treatment and relapse — took the drug and relapsed, according to the letter.
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Researchers found that 52 percent of those who started on Vivitrol relapsed during the 24-week study, compared with 20173 percent of those who started on Suboxone.
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Celgene is working with Seattle-based Juno on an experimental new gene therapy designed to treat people with relapsed or refractory aggressive B-cell non-Hodgkin lymphoma.
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Analysis of health records showed that women who carried several copies of HER733 relapsed more quickly and died sooner than women whose tumors contained only one copy.
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The landlord worked at a treatment center nearby, where he sent tenants who relapsed—this happened all the time, because he funded much of their drug use.
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"Relapsed" disease means a patient achieved remission but the cancer returned, and "refractory" disease means chemotherapy didn't work and "the disease grew straight through it," Perl said.
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The panel recommended approving the treatment for B-cell acute lymphoblastic leukemia that has resisted treatment, or relapsed, in children and young adults aged 3 to 2019.
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She spent three months in state prison in Clinton, New Jersey, was released on parole, then relapsed, failed parole, and went back to prison for 11 more months.
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"Sober" is one of the star's newest releases and made headlines for the fact that Lovato revealed in it that she had relapsed after six years of sobriety.
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One experimented on the party scene and got into opioids; another got into heroin after being prescribed Percocet; another was in recovery when we got together, but relapsed.
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Nina's on edge because of her wild card son who just relapsed, but also because of the major damage control she is pulling on the film and IRL.
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The drug, Kymriah, was approved for patients up to 25 years of age suffering from B-cell acute lymphoblastic leukemia (ALL), who have relapsed or failed chemotherapy. (bit.
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Xospata tablets, approved Wednesday, are for the "treatment of adult patients who have relapsed or refractory acute myeloid leukemia (AML) with a FLT3 mutation," according to the FDA.
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Median survival of that lethal disease with treatment was about 18 months; however, given that she had already relapsed once, I knew that she had to be dead.
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Since the assault weapons ban (which later relapsed) passed in 1994, Democrats have played it fairly conservatively on guns, fearing that it was a losing issue for them.
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But after over two years free of heroin, Mr. Thompson, a former United Parcel Service worker from Iowa, relapsed and decided to try another kind of treatment program.
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After seven years of sobriety, she had relapsed, taking methamphetamine to stay awake at night after she was sexually assaulted in the park where she had been sleeping.
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The patient who died had B-cell acute lymphoblastic leukemia that had relapsed several times after standard treatments, and was being treated at the Children's Hospital of Philadelphia.
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After promising studies in mice, the researchers have opened a study for adults with relapsed or treatment-resistant chronic lymphocytic leukemia, acute lymphocytic leukemia or non-Hodgkin lymphoma.
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So that's a mom of a 3-year-old who now has relapsed into the disease that has the highest risk of killing her of any mental illness.
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With a limit of $1 million for treatment, Jeni says she doesn't know what they would have done if caps were still in place when Erin relapsed in 2011.
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"Depp is an alcoholic and drug addict, and these violent episodes occurred mostly after Depp had relapsed into a cycle of substance abuse," the lawyers said in court documents.
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Last month, Lovato, who has grappled with substance abuse in the past, revealed in a new emotional single that she had relapsed months after celebrating six years of sobriety.
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"The most difficult part of him dying like that is 'cause he and I had had a horrendous fight when I found out that he relapsed," Pinkett Smith said.
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Kardashian, 32, and Odom, 36, wed in 2009 just one month after meeting, and Kardashian filed for divorce in December 2013 after Odom relapsed with his substance abuse problems.
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First- and second-timers were sent to treatment programmes, rather than prison, and their progress was overseen by a judge who could send them to jail if they relapsed.
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Luann de Lesseps may have relapsed after her first six months of sobriety, but after a return trip to rehab, she isn't worried about going down that path again.
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I envisioned them turning their backs on her, and all I could think was, if she has relapsed, she's no less of a person now than she was before.
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Patients in the study had relapsed or failed to respond to multiple rounds of chemotherapy plus stem cell transplants for about half of them, exhausting virtually all available options.
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SANOFI Sanofi said the U.S. Food and Drug Administration has accepted for review the Biologics License Application for isatuximab for the treatment of patients with relapsed/refractory multiple myeloma.
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Eventually she was able to string together something like a year and a half of sobriety—that was its own miracle—before she relapsed in a gas station bathroom.
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Adcetris, which generated about $266 million in North America sales last year, is also being developed in combination with Bristol-Myers Squibb's immunotherapy, Opdivo, to treat relapsed Hodgkin's lymphoma.
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Mr. Ropke, who was originally from the Hudson Valley, attended a rehab program in Saranac Lake, but relapsed after moving into a nearby apartment with people still using drugs.
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Bieber said that he stopped using drugs, but he "never did the actual work" of understanding what drove him to use them in the first place, so he relapsed.
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In the two years since, she had been on and off methadone (which she hated) and buprenorphine, but she had relapsed on heroin three times, well before her pregnancy.
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But then, between August and March, twenty-one people passed through the house, settling in for a few days or weeks before they relapsed, or moved elsewhere, or died.
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A 2015 study in Malaysia found that half the people at compulsory centers relapsed within 32 days of release, compared with 429 days for those who had volunteered for treatment.
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In March, Lovato revealed she celebrated six years of sobriety, but three months later, in June, she released a new song, "Sober" on which she revealed that she had relapsed.
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The treatment, called Kymriah, was approved for patients up to 25 years of age who have relapsed or not helped by prior treatment for B-cell acute lymphoblastic leukemia (ALL).
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In March, Lovato revealed she celebrated six years of sobriety, but three months later, in June, she released a new song, "Sober" on which she revealed that she had relapsed.
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In March, Lovato revealed she celebrated six years of sobriety, but three months later, in June, she released a new song, "Sober," in which she suggested that she had relapsed.
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In March, Lovato revealed she celebrated six years of sobriety, but three months later, in June, she released a new song, "Sober," in which she suggested that she had relapsed.
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In March, Lovato revealed she celebrated six years of sobriety, but three months later, in June, she released a new song, "Sober" on which she revealed that she had relapsed.
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In March, Lovato revealed she celebrated six years of sobriety, but three months later, in June, she released a new song, "Sober," in which she suggested that she had relapsed.
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At 28 I relapsed badly and my family crowdfunded enough money to pay for me to go to a treatment center in the US, where I stayed for seven months.
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A month prior, Lovato, who has grappled with substance abuse in the past, revealed in a new emotional single that she had relapsed months after celebrating six years of sobriety.
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" In the papers, she calls Depp "an alcoholic and drug addict" and states that most of the alleged attacks occurred while when he "relapsed into a cycle of substance abuse.
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In the head-to-head trial of 929 patients whose multiple myeloma had relapsed following prior treatment, those who received Kyprolis plus low-dose dexamethasone on average lived 47.6 months.
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Lil Xan said he relapsed but what really scared him straight were the seizures he suffered ... the effects of quitting cold turkey in his attempt to beat his drug habit.
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Though the previous film had the Danish detective Carl Morck (Nikolaj Lie Kaas) on the way to softening — as much as a hunk of granite can — he's relapsed into misery.
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The bone-marrow transplant, which has become urgent because Nabih has relapsed, will take place in about 10 days, said his doctor, Akif Yesilipek of Medical Park Hospital in Antalya.
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What Sharon doesn't know is that recovering alcoholic Rob has relapsed from the near-cratering of their marriage, as well as his career following a (mostly) false sexual harassment accusation.
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The drug, which generated about $266 million in North America sales last year, is also being developed in combination with Bristol-Myers Squibb's immunotherapy, Opdivo, to treat relapsed Hodgkin's lymphoma.
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Brito weaned himself off drugs with the help of health workers and remained "clean" for 10 years — but relapsed a year ago, and I met him in today's Casal Ventoso.
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Kurupt relapsed and got so wasted on alcohol at the 'Marriage Boot Camp' house, he was rushed to the hospital ... and now booze is banned from the reality TV show.
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For the new study, 247 patients with relapsed or refractory AML and the FLT33 mutation were randomly assigned to receive gilteritinib, and 124 similar patients were assigned to standard chemotherapy.
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They had also lost some of their optimism eight years before, when our mom's brain cancer relapsed after one year of treatment on the only promising drug at the time.
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This time, less than a week into court-mandated medication treatment, Eldred relapsed again—and got slapped with ten days in jail after testing positive for the powerful opioid fentanyl.
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In the new issue of Billboard, the "Sorry Not Sorry" singer, 25, opens up about her recovery from substance abuse, detailing the night she almost relapsed at the 2016 Met Gala.
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A year after his hospital stay ended, the boy relapsed, and his parents launched an online petition seeking access to an experimental cancer treatment that was only available through clinical trials.
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The oral drug was tested in 319 patients suffering from chronic lymphocytic leukemia (CLL) or small lymphocytic lymphoma (SLL), who did not respond to initial treatment or whose cancer had relapsed.
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The pair wed in 2009, just one month after meeting, but she filed for divorce in December 2013 after the former NBA star relapsed with his substance abuse problems and cheated.
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Money also needs to go to harm-reduction programs that distribute the overdose antidote naloxone and clean needles in order to help those who aren't ready to quit or have relapsed.
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As a sober woman, I know that if I had relapsed, the shame and guilt I would feel would send me searching for a deep, dark hole in which to crawl.
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Four-and-a-half years later, this cooperation between the US and Iran has relapsed into enmity, and the optimism has faded into tensions so high they risk all-out war.
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The drug, which generated about $266 million in North America sales last year, is also being developed in combination with Bristol-Myers Squibb's immunotherapy, Opdivo, to treat relapsed hodgkin lymphoma (HL).
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The company did report results for JCAR017 in a small number of patients with relapsed or refractory chronic lymphocytic leukemia, showing that 81 percent of them responded to the cell therapy.
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Health officials are warning doctors to more closely monitor patients with severe lung damage caused by vaping, because some have relapsed or died shortly after being sent home from the hospital.
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" The night @CountessLuann relapsed she had "2 or 3 watermelon martinis, 2 bottles of rosé by myself and then I had a six pack of beer, I can't have just one drink.
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"Depp had relapsed into a cycle of substance abuse," Heard alleged in recent court documents obtained by PEOPLE in her defamation suit against comedian Doug Stanhope, who published an article in TheWrap.
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Then when technical problems with his student loans led to him missing the first day of classes the following school year, Alex relapsed — dying of a deadly heroin overdose in August 2005.
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Some are turning to blind gossip sites to when exactly Lovato relapsed and are tweeting their support and sharing #HowDemiHasHelpedMe stories as they wait for official news from Lovato or her family.
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"After that, I was nine months cancer free and right as I went in to do my scans, I found out that I relapsed with metastatic osteosarcoma in my lungs," McDonald says.
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She told PEOPLE exclusively backstage that the Skinnygirl maven was one of the people who helped get her to back into an alcohol treatment center back in July, after she had relapsed.
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Kardashian first filed for divorce in December 2013 after he relapsed with his substance abuse problems and cheated, however she called off their protracted divorce following Odom's near-fatal overdose last October.
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The last time she relapsed, in September 2014, her probation officer sent her back to jail after she tried to fake a drug test by hiding her daughter's urine in her jeans.
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On May 17, the Food and Drug Administration approved nivolumab for patients with Hodgkin's lymphoma in cases like Jason's, where the patient has relapsed or the cancer has progressed after a transplant.
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He had issues like a lot of people: He had a drug problem—he was addicted to methamphetamine—and had relapsed for maybe a month and a half before he was killed.
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The study tested Agios' ivosidenib, a once-a-day pill, in patients with an IDH1 gene mutation who had relapsed or were not helped by prior treatment for acute myeloid leukemia (AML).
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According to Newman-Polk, when her client relapsed, she was genuinely trying to comply with probation—and did everything asked of her, including attending outpatient therapy and seeing a doctor for medication.
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He even moved in with the former Real Housewives of Beverly Hills star while ailing and was her staunchest supporter after she relapsed with her substance abuse and was arrested twice last summer.
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If Lovato has relapsed, any opioid use — accidental or otherwise — likely would have been overwhelming for someone who had spent years sober and unaware of the changing drug landscape in LA, experts said.
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Lovato, 25, has been public about her struggles with drugs and alcohol, and last month revealed in her song "Sober" that she had relapsed just three months after celebrating six years of sobriety.
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" In June, Lovato released her single "Sober," revealing that she had relapsed, singing: "Momma, I'm so sorry, I'm not sober anymore/And daddy, please forgive me for the drinks spilled on the floor.
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Patients with relapsed multiple myeloma taking part in the trials who were experiencing clinical benefit will be allowed to continue treatment, but no new patients will be enrolled for now, Bristol Myers said.
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"It's been devastating because I just went through a transplant in January and I relapsed so quick, so I have to find another donor," Rabaca, a mother of five, told the news station.
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He wrote on Twitter that he feared she had relapsed: "I'm driving my pickup truck to get her stuff and move her out with me and get her back into treatment," Aaron said.
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A man named Steve Jesi had called to say his daughter, Stephenie, 229, who had been in and out of the Gloucester program, had relapsed for a third time, overdosed and been found dead.
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In one clinical trial, 2750 out of 2000 patients with relapsed and refractory acute lymphoblastic leukemia (ALL) were in remission after six months (four with the help of at least one other other therapy).
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"There has been an urgent need for novel treatment options that improve outcomes for patients with relapsed or refractory B-cell precursor ALL," Novartis, the drug company that makes Kymriah, said in a statement.
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" Meacham described the 17th president's history with racism, noting that Johnson once said in a state message that "African Americans were incapable of self government and relapsed into barbarism if they weren't closely supervised.
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In the late aughts, after Williams relapsed into alcoholism, went through a divorce and had to postpone a live tour to get open-heart surgery, Itzkoff was surprised by his candor about those troubles.
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Tibsovo is Agios' first fully-owned drug and was approved on the basis of an early-stage trial in patients with acute myeloid leukemia whose disease has been resistant to treatment or has relapsed.
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Spooked by the escalating U.S.-China trade war, long-term interest rates embedded in government bond markets - widely seen as the most accurate predictors of future economic activity and inflation - have relapsed into deep troughs.
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"Endeavor is the only (relapsed multiple myeloma) study to demonstrate a survival benefit in a head-to-head comparison with a current standard of care regimen," Amgen research chief Sean Harper said in a statement.
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Sanofi, whose shares have underperformed major rivals, reiterated its strategy to rebuild its position in cancer and said it expected a first regulatory submission of its monoclonal antibody for relapsed refractory multiple myeloma in 2018.
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He said the trial did not show a big difference between patients whose leukemia was refractory, meaning they had stopped responding to treatment, and patients who had relapsed, or might have responded temporarily to chemotherapy.
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The treatment, Lorbrena, is designed to treat advanced non-small cell lung cancer in patients with a mutation of the ALK gene, who have relapsed after being treated with ALK inhibitors, such as Pfizer's Xalkori.
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After analyzing tumor tissue from before and after treatment in patients who relapsed, the researchers found that in a third of patients the CD19 protein targeted by Yescarta was no longer present on cancer cells.
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The Rock and Roll Hall of Famer had been fighting intestinal issues for awhile but his condition relapsed before the holidays, forcing the Eagles to pull out of their Kennedy Center Honors appearance in December.
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The study was expanded to include a total of twenty volunteers; after six months, six remained in remission, while the others had relapsed to one degree or another, suggesting the treatment might need to be repeated.
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Just before he relapsed for the last time in December, his parents Kathy and Dennis Schnur learned about something else: a vaccine, which could numb him to the effects of heroin and prevent him from overdosing.
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Novartis said on Tuesday it requested Food and Drug Administration (FDA) approval for Kymriah for adult patients with relapsed or refractory diffuse large B-cell lymphoma (DLBCL) who do not qualify for a stem cell transplant.
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The company is also targeting the several thousand people a year who have relapsed or refractory diffuse large B-cell lymphoma (DLBCL) diagnosed, but it will not file Kymriah for that group until later this year.
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She worked as a hospital nurse and had seen patients admitted for infections after injecting themselves with buprenorphine and other opioids, as well as countless others, like Tess, who had relapsed after being on the program.
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"At the end of 2018, global financial markets relapsed quite a bit which had an impact on M&A in power and utilities," Miles Huq, EY's leader for global transaction advisory services power and utilities, told Reuters.
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As for when Chris exactly relapsed is still unknown but the people closest to him, after incessant over-analyzing, think it must have happened after Chris tore a ligament in his leg on vacation with his girlfriend.
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Calquence is currently approved for treating adults with relapsed or refractory mantle cell lymphoma in the United States, Brazil, UAE and Qatar, and is being developed for the treatment of chronic lymphocytic leukemia and other blood cancers.
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A long-term followup from one of the initial studies, administered 17 to 74 months following treatment, found that only two out of 19 subjects had relapsed, and none reported harm from their participation in the therapy.
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Though she hasn't relapsed, she reminds Ralph that there is no cure for her disease, and by the end of the episode she feels like they need to slow things down so she doesn't get too overwhelmed.
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Cornell famously struggled with both drug abuse and alcoholism throughout his career; he claimed in 1994 to have been a daily drug user by age 13, and reportedly sobered up and relapsed multiple times over the years.
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In the study of 389 patients whose CLL had relapsed after up to three prior treatment regimens, median time until disease worsening, or progression-free survival (PFS), was 17 months for Rituxan plus Treanda, know generically as bendamustine.
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Strawberry's campaign is a rebuke of the privacy promised in Alcoholics Anonymous and suggests that "someone get up and grab on to the pillory and confess to the world that they've relapsed," Haroutunian said in an interview Tuesday.
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" Lukey touches on substance abuse, writing, "I relapsed in my flat with only you there beside me, I saw in you what I carry too, I wish we had spent more time together sober, but we rarely were.
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Novartis plans to request another approval later this year of the same treatment (which it calls CTL019 or tisagenlecleucel) for adults who have a type of lymphoma — diffuse large B-cell lymphoma that has relapsed or resisted treatment.
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But he eventually relapsed, leading to the encounter in which police used a stun gun to arrest him, and the final incident in which a police officer with mental health crisis training helped get Kevin longer lasting care.
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Three months after infusion, the overall response rate (ORR)among 51 adult patients with relapsed or refractory diffuse large B-cell lymphoma (DLBCL) was 45 percent, Novartis said, with 0173 percent complete responses (CR), or no sign of disease.
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Young seemingly regrets his actions—he said he was a recovering alcoholic who relapsed after 18 months in the airport after being depressed by the death of a family member—and promptly plead guilty to the charge against him.
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Despite reports Lovato relapsed in February, a source close to the singer recently told PEOPLE the rumors are not true — but that the star did choose to check into a treatment facility recently to continue working on her health.
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An independent data monitoring committee recommended an increase in the number of patients to 450 from currently 330 in the ongoing trial named B-MIND, which tests the tafasitamab drug against relapsed or refractory diffuse large B cell lymphoma.
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Juno had disclosed last Thursday that two people in the trial had died after the company added the chemotherapy drug fludarabine to the regimen in the trial, which involves adult patients with relapsed or refractory B cell acute lymphoblastic leukemia.
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I think it was Pain Killer, which is sort of funny in a sick way because Johnny Cash once relapsed after taking pain killers following a surgery, so the next time he had to have surgery he didn't use them.
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When my report confirmed what the Ottawa doctors found, that she had indeed had a short remission and then relapsed, the patient, who had prayed to d'Youville for help and, against all odds, was still alive, wanted me to testify.
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The drug was cleared to treat adults with newly diagnosed AML and tumors expressing the CD103 antigen, as well as patients aged 2 years and older with CD33-positive AML who have relapsed, or did not respond to initial treatment.
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Updated early stage trial data presented at the annual meeting of the American Society of Clinical Oncology showed that use of the therapy, axi-cel, induced remission in 73 percent of 11 evaluated patients with relapsed acute lymphoblastic leukemia (ALL).
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The only nationwide survey of students in collegiate recovery programs, which was published in 2015 and looked at 29 schools, found that, on average, just 8 percent of students who'd been in recovery for about three years relapsed each year.
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In a first for gene therapy in the United States, regulators approved Kymriah on Wednesday for patients up to 25 years of age who have relapsed or not been helped by previous treatment for B-cell acute lymphoblastic leukemia (ALL).
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One recent afternoon, Christian Robinson, a lanky 18-year-old who plans to join the Marines after he graduates from high school, said his mom went to rehab when he was 11, but she relapsed last year on meth and heroin.
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Expected to show progress as this season began, even with a rookie quarterback, Sam Darnold, the No. 3 pick in the N.F.L. draft, the Jets instead relapsed into a familiar cycle of offensive stagnation, self-inflicted penalties and late-game collapses.
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Over the summer, Ixcell Perez and her mother Dalia Perez traveled on a bus for four days to the border crossing at Tijuana, Mexico, so Ixcell could undergo treatment in the U.S. after her leukemia relapsed, Good Morning America reported.
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Once he relapsed after the CAR-T treatment, tests on his blood indicated that all of his leukemia cells carried genetic changes from the treatment, and all the cells had identical traits indicating that they originated from the same cell.
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He stayed for more than seven months, sleeping on the top bunk in a four-bedroom Brooklyn home crammed with about 30 men, some of whom were drug addicts who relapsed to be able to keep their housing, Mr. Bates said.
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It is not clear whether any of the patients who relapsed or died had started vaping again when they got home, Dr. Schuchat said, but she said that it was important for addiction counseling to start before patients leave the hospital.
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She went to rehab, relapsed (after Alexandre de Lesseps and their children Victoria and Noel, filed a lawsuit against her over an $8 million house sale), went back to rehab, and later struck a plea deal in the case to avoid jail time.
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"There's no data for relapsed patients, so [researchers] have no idea where they are, no idea what subtypes of disease they have, no idea what sequence of therapies they've received — we aren't able to track what happens over time," Dr. Ellis says.
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In August, the Swiss multinational Novartis won approval to offer Kymriah (tisagenlecleucel) for the treatment of patients 2475 and younger who have relapsed twice, or whose B-cell precursor acute lymphoblastic leukemia (ALL) has been dubbed refractory, meaning stubborn or resistant to treatment.
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Jonathan Rhys Meyers has had a rough time of late ... his wife had a miscarriage earlier this month, he relapsed and ended up again in rehab for alcoholism, but he's just snagged a huge honor ... Best Actor at the Boston Film Festival.
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His wife reveals in this week's issue of PEOPLE that after years of sobriety, he'd recently relapsed and says that due to the prescription drugs in his system, he was not in his right mind state at the time of his death.
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Among the older patients, many who appeared to be newly addicted had actually relapsed or never recovered from prior addictions: some faked pain to get pills from well-meaning doctors; others got them from pill mills where shady physicians wrote prescriptions for cash.
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When the memoir was published, Nic had relapsed again, returned to rehab, and was again in recovery; his own memoir about his experience throughout two years of addiction, Tweak: Growing Up on Methamphetamines, was published at the same time as his father's.
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"The primary analysis of the first Phase III study of Venclexta in relapsed/refractory CLL shows a profound improvement in PFS versus standard bendamustine/Rituxan, with consistent effects in all-risk subsets," researchers concluded in a brief summary of interim data released on Tuesday.
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She relapsed straight after diagnosis, as her consultant warned her that many do, but with support she has managed to carry on with normal life – for example, walking arm in arm with her dad on days she couldn't walk the kids to school alone.
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In April, fans speculated that Lovato had relapsed when the same photo was posted to separate Instagram accounts: In one post by singer Hayley Kiyoko, Lovato was holding a cup containing a yellow liquid; in the other, the cup appeared to be blurred out.
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Kymriah, already approved for treatment of children and young adults with r/r B-cell acute lymphoblastic leukemia, will now get speedy scrutiny for use against relapsed or refractory (r/r) diffuse large B-cell lymphoma (DLBCL) in adults, the company said in a statement.
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The study is the first to show that patients who had previously been given CD19 treatment and relapsed could later be rescued by a different T-cell treatment, said Dr. Terry J. Fry, the first author of the study, from the National Cancer Institute.
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Lovato's performance at the 62nd Annual Grammy Awards will mark her first stage performance since the release of her emotional June 2018 single "Sober" (in which she admitted that she had relapsed after six years of sobriety) and her overdose that followed a month later.
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I also heard a few reports of patients being kept at the hub level for too long instead of being referred to spokes once they got better, and spoke doctors dropping patients when they relapsed — neither of which is supposed to happen, according to Brooklyn.
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Before, he had relapsed as quickly as a matter of days — not only exposing himself to the risk of a deadly overdose but leading to a spiral of drug use that hindered just about every aspect of his life and, often, landed him in prison again.
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As an example, in 2012 and with Pelotonia funding, John Byrd, MD, a senior investigator at the OSUCCC – James was able to conduct the first clinical testing of a drug called ibrutinib in relapsed chronic lymphocytic leukemia (CLL), a very lethal form of leukemia in adults.
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"We now know that Kyprolis not only significantly extended progression-free survival compared to Velcade, but also overall survival, making it a clinically meaningful advance in the treatment of relapsed or refractory multiple myeloma," Dr. Meletios Dimopoulos, one of the study's lead investigators, said in a statement.
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The family of Stacey Stanley – one of three women whose remains were found Tuesday in Ohio after a desperate 911 placed by an allegedly abducted woman – tells PEOPLE that local authorities initially dismissed reports she was missing, suggesting instead she'd relapsed following six months of sobriety.
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"We've got one person who has completely relapsed, back to previous drinking levels, we have five people who are completely dry and we have four or five who have had one or two drinks but wouldn't reach the diagnosis of alcohol use disorder," Sessa told the Guardian.
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Affleck has also accepted that the second word in Alcoholics Anonymous does not apply to him — certainly not after he (briefly) relapsed in the fall, turning up smashed on TMZ a few months after making it known that he had achieved one year of continuous sobriety.
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The list price is 282,000 pounds ($369,000) per patient, given as a single intravenous infusion, but Novartis agreed to offer the therapy for relapsed or refractory diffuse large B-cell lymphoma (DLBCL) at a confidential discounted price, the National Institute for Health and Care Excellence (NICE) said.
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The F.D.A. panel recommended approval of it for a narrow subset of severely ill patients, only a few hundred a year in the United States: those ages 3 to 25 who have B-cell acute lymphoblastic leukemia that has relapsed or not responded to the standard treatments.
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In the meantime, the panel recommended that the FDA approve the drug for patients ages 3 to 25 with relapsed B-cell acute lymphoblastic leukemia, the most common form of childhood cancer in the US. The agency does not have to follow that recommendation, but it typically does.
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The singer, who recently revealed she relapsed after being sober for six years, tweeted a cryptic message on Thursday, leading her followers to believe there could be a rift between her and Mike Bayer, who is also the CEO of CAST Centers, a treatment center co-owned by Lovato.
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In October, Kite Pharma, a newly purchased subsidy of California-based Gilead Sciences, was approved for Yescarta (axicabtagene ciloleucel) to treat adults with some kinds of large B-cell lymphoma whose cancer has not responded to treatment and who have relapsed after at least two other kinds of treatment.
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Kite presented data showing that axi-cel induced remission in 73 percent of 11 evaluated patients with relapsed acute lymphoblastic leukemia (ALL) and said it plans to launch a Phase 2 trial in the fourth quarter of this year, possibly at a lower dose than is currently being tested.
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One heading, from The Sun, dismisses a concert cancellation with the phrase "Demi's Downer," while earlier this month, The Daily Mail published a story showing a recently-relapsed Lovato leaving a Hollywood nightclub alongside a series of unsolicited paparazzi shots, claiming the singer had "gone off the rails".
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The following month, he stood nearby in the hospital's hallway as my team and I discussed and visited our patients: younger and older people with new leukemia diagnoses, with leukemia that had relapsed, those just admitted to the hospital, and those who had been on our service for weeks.
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Kim Hyong Ryong, North Korea's Vice Minister of the People's Armed Forces, said at the Xiangshan Forum in Beijing that North Korea has worked to build lasting piece but that the situation has relapsed into a "dangerous, vicious cycle" of exacerbating tensions because of the actions of the U.S. and South Korean governments.
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Kymriah, already approved for treatment of children and young adults with r/r B-cell acute lymphoblastic leukemia (ALL), will now get speedy scrutiny by the U.S. Food and Drug Administration for use against relapsed or refractory (r/r) diffuse large B-cell lymphoma (DLBCL) in adults, the company said in a statement.
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We can argue about which of these drugs represent transformative advances (a new medicine for breast cancer, tested on women with relapsed or refractory disease, increased survival by just a few months; a drug for a type of leukemia had a more lasting impact), but we know, roughly, the chain of events that unfolds when a trial is positive.
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Agios, which holds full rights to ivosidenib, said it plans to use the early data to seek swift approval of the medicine, a similar path that led to the August U.S. approval of Idhifa, which Agios shares with Celgene Corp.. Idhifa is approved to treat relapsed AML in patients with a similar genetic mutation known as IDH2.
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She also alleges that "despite her depression, Ms. Greenleaf's quality of work did not suffer; she never missed a taping of Talk Stoop or any of her work obligations to NBC and LX." In November, Greenleaf "relapsed into a severe depression after the death of a close friend, as she revealed to her boss at the time," the documents read.
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Among the 16 on his docket: a 48-year-old disabled coal miner who abused opiate pills for a decade, is not on Suboxone and is thriving, finally, after several relapses; and a 26-year-old mother who for six years abused opioid pills, including black-market Suboxone, and now takes 10 milligrams of prescribed Suboxone a day and has not relapsed.
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