The condition can appear in German shepherds as a result of "autosomal recessive inheritance" — or recessive gene inheritance, according to Claudia E. Reusch and her chapter in Canine and Feline Endocrinology.
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Estella was paler and more recessive, already critical and disappointed.
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When Dylan was two months old, his parents took him to see a geneticist who gave the diagnosis – autosomal recessive microcephaly – meaning the condition resulted from a recessive genetic mutation carried by both of his parents.
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If you remember high school biology, red headedness is a recessive trait.
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In working on auto-tuning, you'll see that recessive genes get expressed.
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Next comes Beth, thirteen: recessive, unswervingly kind, and doomed to die young.
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This in itself is an important step in maintaining health as a top priority as closely related dogs typically carry the same recessive genes, and when paired together, allow these recessive genes to be expressed—good and bad.
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At some times the music was recessive enough to be a non-issue.
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But some recessive conditions, like hip dysplasia, could not simply be bred away.
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The effect is simultaneously dominant and recessive, like a mountain made of glass.
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It is exceedingly rare that both parents would carry the recessive genes for microcephaly.
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It's a recessive mutation in a gene called TAF1A that Linsey and Noel both carry.
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"I had to go on Wikipedia to remember what dominant versus recessive meant," he says.
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To complicate matters, some cats may have unusual recessive genes that make them more valuable.
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"Genetic similarity increases the risk for expressing recessive, potentially pathological, traits and abnormalities," she says.
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His mother, who had an interest in the occult, was a defeated and recessive figure.
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This pattern is already well known with one particular single-gene recessive disease, sickle cell anemia.
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Recessive diseases, such as sickle cell anemia, usually require two defective copies of the same gene.
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But whatever your social values, it creates a relatively high risk for passing on recessive genetic diseases.
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And our definition of genetic disease as either dominant or recessive might need to be tweaked, too.
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Some would say that is because it takes generations for certain inbred recessive genetic traits to manifest.
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The Saddlebrook, New Jersey, couple's 220-year-old daughter Madeline has autosomal recessive polycystic kidney disease (ARPKD).
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There's a 25 percent chance if neither parent has red hair but both have the recessive trait.
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But it didn't die; it became a recessive gene within the GOP, revealing itself now and again.
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So there was something kind of undiscovered and unsung and even kind of recessive about the group.
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Because my parents had the matching recessive gene, out of three children, two of us were albino.
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The dark jewel-tone blue and maroon don't seem modern at all; they seem recessive and dark.
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So the researchers then took that knowledge and used CRISPR to turn the patient's stem cells with this MYL3 genetic variant from being heterozygous, meaning they have one normal and one recessive form of the variant, to being homozygous, so that they have two recessive forms of the variant.
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Some of these genes can be recessive, meaning a kitten without stripes could still breed one with stripes.
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Nicholas was "autosomal recessive," meaning he had inherited two mutated genes — one from each parent — that caused microcephaly.
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They are produced when two Bengal tigers with a recessive gene that controls coat color are bred together.
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Their unusual coloring is the result of a recessive gene, much like the appearance of blue eyes in humans.
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But "we're not at all ready to revise the government's 'philosophy', so no austerity or recessive measures," he added.
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Batten's disease is recessive — a patient must inherit two mutated versions of a gene, MFSD8, to develop the disease.
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Given recessive fitness effects, the median Neanderthal fitness correlated to a genetic load of 0.39 compared to the median human.
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You may have heard that the recessive gene for red hair will be gone by the end of the century.
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Alas, idealism is now a recessive gene in me after so many crushed hopes and covering one-too-many massacres.
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Because the gene was recessive, moreover, there was no way to tell just by looking which adult fly received it.
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The blocks themselves might pass for recessive Rothkos, pulling in a viewer's gaze instead of glowing out to meet it.
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This distinction is important because it's well documented that marriage between close relatives can increase the possibilities of recessive disease.
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At first there may have been just one person who had no outward symptoms but who passed on a recessive gene.
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The FDA relieved the pressure somewhat in 2015, allowing for one genetics test for Bloom syndrome, a rare recessive gene disorder.
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Many of the patients had conditions that are considered recessive, yet they carried a just single defective copy of the gene.
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"We were interested in the association with coat colour because chocolate pigmentation is recessive in dogs," the authors write in the study.
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Thoroughly convinced or simply desperate to escape this creepy situation, Ben leaves Haley at home to fester in her tragic recessive traits.
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When the catalog for I.V.F.-ready bull semen arrives in the mail, she'll need to know about dominant and recessive genetic traits.
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In ''The New Normal,'', Alexander Fury argues that there is something intentionally recessive — radically banal, even — about the current men's wear collections.
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The dark coloration of the melanistic leopards' coat is attributed to a recessive gene that causes the loss of the normal function.
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In the Ashkenazi Jewish population, for example, such data has helped recessive diseases like Tay-Sachs virtually disappeared in cases of arranged marriages.
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Even when both parents carry the recessive mutation of the same gene, there's still only a 1 in 4 chance they'll be affected.
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She likes to draw out recessive characters—the unhappy, the untrustworthy, or the downright unlikable—and bring them, however uncertainly, into the light.
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The other museums reflect light; this one absorbs it, making it look, despite its size, discreet and recessive, about silhouette rather than bulk.
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Possibly, although we get a lot of information later about the recessive-gene issue with Gendry and the whole "seed is strong" business.
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The gender ratio is that of a rooster and his hens, and in this setup, Mr. Siddi's recessive mediocrity is all the more glaring.
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Many of these conditions are autosomal recessive, so if both parents are carriers there is a 21% chance that their children would have it.
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And it would automatically insert the chosen gene into both copies of the offspring's DNA, effectively turning a recessive trait into a dominant one.
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It would be easy to forget, especially these days, that American DNA contains another trait — though clearly a recessive one: the desire to disappear.
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It's a recessive gene, so if you inherit only one copy from a parent — like Cara and Tom did — you will not have uncombable syndrome.
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Her condition, called heterochromia, is the result of a recessive gene inherited from her parents which manifests itself in the peculiar pigmentation in her iris.
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There's a 50 percent chance a kid will be redheaded if one parent has red hair and the other has a red hair recessive gene.
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By the spring of 1999, however, he and his team had worked out that the recessive mutation had to lie in one of two genes.
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But he cannot do anything for the problem in my "good" eye, because I have degenerative myopia, a hereditary condition caused by two recessive genes.
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And over the years, as he has garnered control, the most recessive traits of his filmmaking style have begun to combine in more flagrant disorder.
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If black is recessive or negative space, why does the black reduce the painting's yellow peninsula or the slashes of blue to a minor role?
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I've called it the recessive gene on the right, and it's why I think conservative thought leaders have a responsibility to not stir up these anxieties.
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They contain around 32,000 genes (more than humans), of which two recessive ones contribute to a build-up of carotenoids, such as alpha- and beta-carotene.
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In the 2016 study, Betz and her team illuminated three genes that were responsible for the recessive cases of uncombable hair syndrome: PADI3, TGM3 and TCHH.
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She pulls Ben aside to complain about Olivia, then phones Haley (cast off due to recessive qualities) to commiserate about how none of this is fair.
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The Amish may be more vulnerable to recessive inherited conditions because they are descended from a small number of ancestors and tend to intermarry, Tester said.
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Fumarase deficiency (FD) is an autosomal metabolic recessive disorder, meaning it is necessary for an individual with the condition to receive the mutant allele from both parents.
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But while you may have heard at some point that, say, blue eyes are determined by a single, recessive gene, it's a little more complicated than that.
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Yet it wasn't until the Middle Ages that the recessive gene mutation associated with tabby cat markings (the distinctive blotched stripes) appeared in the feline gene pool.
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The female koala, who has light fur, does not have albinism but owes her pale colouration to a recessive gene, thought to be inherited from her mother.
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Schuyler was prolific, pugnacious and very much in the public eye; Larsen was recessive, and vanished from literary life after publishing two novels and a few stories.
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Gantz's only option was to blindly engineer, and crossbreed, scores of flies, in hopes that two carrying the recessive mutation would eventually find each other and mate.
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Its pale coat, the result of a recessive gene found in just one in ten cubs, inspired the term 'Great Bear Rainforests,' coined by environmentalists in the 1990s.
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Following suit is the theory that two people with blue eyes will automatically have a child with blue eyes due to the gene being recessive, rather than dominant.
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Hanna, a thirteen-year old from New York, is fighting Spinocerebellar ataxia, autosomal recessive 9 (SCAR21625), an incredibly rare genetic disorder characterized by a laundry list of symptoms.
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Ortega is the more recessive of the two; he is a wily negotiator, with a street fighter's swagger, but he is a clumsy speaker and avoids public appearances.
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Thirteen of the diseases they identified had been previously categorized as "recessive," meaning people would need to inherit the same mutation from both parents to come down with symptoms.
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"We found out he had recessive dystrophic epidermolysis bullosa right after he was born because he didn't have skin on his feet," Monnier, 31, tells PEOPLE of her son.
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Indeed, the Folk Art Museum looked about as un-MoMA as could be imagined: a small, dark, recessive sculpture set against the mega-museum's stretch of glass and steel.
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They nestled in my hair while I Googled all the diseases a future child might have, all the recessive-but-fatal genetic flaws my husband and I could carry.
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"Peabrain" isn't intended as an insult in this original hint for MENDEL, the early genetic researcher who crossed those plump and wrinkly peas and mapped dominant and recessive traits.
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James began by noting that two brown-eyed human parents can sometimes produce a blue-eyed child, though only if both parents carry a copy of the recessive gene.
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Even very flat Color Field painting, by denying recessive illusion, can emphasize its status as a physical presence in the room, and so resembles, in effect, a flattened sculpture.
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The combination of this music with the preening, aggressive-recessive manner of Mr. McGregor's choreography is often close to unbearable, and the scrambled structure offers no path through the mire.
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Many a geneticist, however, would identify carrots' recessive gene, and selective breeding, as explaining the predominance of the orange variety, rather than any links with the struggle for Dutch independence.
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Just under three feet tall, cut from a piece of poplar, she has the recessive, round-shouldered posture of a shy adolescent and the large-eyed face of a dove.
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Of these, 81 groups had losses of genetic variation more extreme than those found in Ashkenazi Jews and Finns, groups with high rates of recessive disease because of genetic isolation.
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Depending on what version of the gene we inherit — dominant or recessive — certain traits simply get turned on and off, like a light switch; think Gregor Mendel and the pea plants.
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Because albinism is a hereditary condition—it comes from a recessive gene—there's "a 'whitening' mutant gene in the giant panda population in Wolong," as noted in the Sichuan press release.
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"As we started building out the family structure, it became apparent to us that this was most likely a recessive disorder," David Tester, the lead scientist on the case, told CNN.
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He is recessive, lightly ironic, evasive ("I think I write about Englishness," Barnes once said), puzzling over his life and, very often, his attachment to a charismatic and congenitally unfaithful woman.
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HARDING TOWNSHIP, N.J. — Shy recessive types can appreciate art at a safe remove from the action, but collectors usually need to get off the sofa to capture the object of desire.
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Still, Goldfield is right to point to the risks of government's increasingly recessive role, and to make one worry how it will play out by the time the millennials become grandparents.
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Her beautiful eyes — the result of a condition called heterochromia that develops because of a recessive gene from her parents — quickly captured the hearts and minds of animal lovers the world over.
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She is among the Ghanaians who have albinism, a recessive condition that drastically reduces the amount of melanin in the skin and can lead to problems like vision loss and skin cancer.
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Forster weaves his own onstage way through "The Inheritance" in the shyly bespectacled Morgan (Paul Hilton), who functions as narrator, literary sage and emblem of a more recessive era for gay men.
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The snapshots are affectionate and admiring, and the contradictions in them can give you whiplash — until the end Avedon was pavonine and recessive, autocratic and inhibited, everyone's best friend and utterly inscrutable.
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Jasin, 17, and Haddad, 16, first met in 2001 as infants, both suffering from the deadly Maple Syrup Urine Disease — a recessive metabolic disorder where the body is unable to process protein normally.
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Past studies of Neanderthal genomes found they contained a high number of recessive genetic traits characteristic of inbreeding, which led researchers to conclude that there were only a few thousand Neanderthals in Europe.
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The UDN was also able to determine that Quinn's mutation was de novo—meaning it didn't come from recessive genes in Mills and Aronin, but that it had spontaneously occurred on its own.
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This means the gene causing a snail's directional twist (and body asymmetry in other animals), described last year in Current Biology, could take more than a generation for its recessive form to appear.
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Mutations are generally caused by recessive genes, said vonHoldt, which means that an offspring must have two copies of a mutated gene for there to be an actual phenotypical, or physical, effect, she said.
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It's accepted that higher relationship coefficients increase the risk of recessive or deleterious traits showing up in offspring (including congenital birth defects), but the chances of that happening are not easy to pin down.
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These genetic kinship circles are expanding and connecting us through networks of recessive, dominant and autosomal genes; mitochondrial DNA; and complex interactions with the environment that shape how genes express themselves as we develop.
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"The decision was taken considering the recessive conditions in which the economy has been performing, and with a view to defining a path of interest rates compatible with economic recovery," the central bank said.
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Featuring a book by Craig Lucas and music by Daniel Messé, with the lush-voiced Phillipa Soo in the title role, it is pleasant to look at, easy to listen to and oddly recessive.
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This study, however, estimates that there were tens of thousands of our ancient cousins in Europe, and that the high numbers of recessive mutations could be explained by living in small, genetically isolated sub-populations.
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Rhaegar (a Targaryen) and Lyanna (a Stark, not a Tully) could have blonde or brunette kids, but the chance of white blonde was slimmer than brunette since the lighter hair color is a recessive gene.
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And, according to Gizmodo, the majority of people who advocate against these marriages are people who are just afraid that a close gene pool will lead these people to have kids with recessive, potentially harmful traits.
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If recessive disease mutations are cataloged, they could potentially be used for prenatal or premarital screening programs, which can be "immensely powerful," said Priya Moorjani, an author of the paper and a postdoctoral researcher at Columbia University.
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Mr. Marshall complicates this idea by taking it in two directions: His "self-portrait" is simultaneously recessive and unmissable, with his eyes and his assertive, mock-cheerful, near-skeletal smile that shine like pin spots in the dark.
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Recombine, led by Alexander Bisignano, offered a medical test that would sequence the genes of two parents who were trying to get pregnant, letting them know of any potential genetic disorders or recessive mutations that might affect their child.
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Image: Rob Hanson/WikimediaThe gene for the chocolate color, unlike the genes for the black and yellow color, is recessive in Labradors, which means both mom and dad have to be chocolate-colored to produce the trait in pups.
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Accordingly, if a mutation — beneficial or harmful — is passed down to different offspring, conventional genetics show that it's possible for wolf offspring to acquire two copies of a recessive genetic mutation, which would then manifest as a physical change.
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To apply a neutral model of evolution to a population, Hahn explained, you don't have to know how strong selection is, how large the population is, whether mutations are dominant or recessive, or whether mutations interact with other mutations.
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Usually, UHS is what scientists call "recessive," meaning a child must inherit one gene that codes for this condition from the mother and one such gene from the father in order to show symptoms of it, according to Betz.
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This created a kind of serial copy-and-paste function; the altered gene would be inserted into both copies of the DNA, rather than just one, effectively turning a recessive trait, like a missing vein, into a dominant one.
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The arguments tend to involve pseudoscience—speculation about the effects of increased sunlight over the British Isles in a warming climate, misunderstanding of the nature of recessive genes—and can often be traced, like much quackery, to profit motive.
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While Malek has shown up almost everywhere, happily spinning stories for interested voters, Cooper has proved to be a more recessive presence, and at many important events — like the star-studded Governors Awards in November — he was absent entirely.
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"Solo IVG -- unlike 'natural' reproduction -- increases the possibility of homozygosity (identical genes) for recessive genes, contributing to a greater risk of disease and disability," she wrote in a 2015 paper in the Oxford Academic Journal of Law and the Biosciences.
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Marrying a close relative markedly increases the chance that both parents are carriers of dangerous recessive genes, which can then cause disease when a child inherits a copy of the gene from both parents, as will happen in 25% of cases.
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Brett Kopelan, executive director of the Dystrophic Epidermolysis Bullosa Research Association of America, has a 10-year-old daughter, Rafi, with recessive dystrophic EB. Between January and August, $751,1778 for wound/burn dressings was charged to Kopelan's insurance company, he says.
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In their early scenes together, the recessive Mr. Bateman (he's an actor against which other actors bounce) and the industrious Ms. Kidman (you can see her working even when she goes blank) come across as two people who've just met.
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One way to see "The Rose Tattoo" is as a reversal of "The Glass Menagerie": instead of frigid, domineering Amanda and obedient, recessive Laura, we get a mother who shrinks from the world and a daughter who runs toward it.
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"We all carry changes in our genes — we can call them variants or mutations — and it's totally normal to be a carrier of a recessive genetic disease," says Katie Sagaser, MS, CGC, a prenatal and preconception genetic counselor at Johns Hopkins Medical.
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"In view of our findings, familiar medical categories such as 'complex' versus 'genetic,' or 'dominant' versus 'recessive' begin to appear more like continuums," said lead author Lisa Bastarache, a data scientist at Vanderbilt University Medical Center's Center for Precision Medicine, in a statement.
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Dement made the decision to focus on Dobermans and, by the end of the 280s, he was the proud custodian of a large colony and had established that narcolepsy in this breed was caused by the transmission of a single recessive gene.
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It was all brutal dynastic warfare and recessive genes and feuding families (her husband reigned for just six months, in 1762, before dying in murky circumstances), with a single crucial exception: Catherine had genuinely altruistic motives to go along with her dynastic ambitions.
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Dement made the decision to focus on Dobermans and, by the end of the 2000s, he was the proud custodian of a large colony and had established that narcolepsy in this breed was caused by the transmission of a single recessive gene.
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Shortly before that, and as sort of a trial run before opening up the floodgates, 23andMe was able to test for a genetic carrier disease called Bloom Syndrome, a rare recessive gene disorder characterized by shorter height and a predisposition to develop cancer.
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Having lighter eyes didn't give anyone a particular survival advantage, but because the gene for blue eyes operates similarly to a recessive trait ( though it's a little more complicated), blue-eyed fathers could better guarantee that their children were, in fact, their own.
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"We finally figured out that it was an autosomal recessive condition where both bad duplications came from both parents, and those children were unfortunate to get the double dose, " Michael Ackerman, director of the Windland Smith Rice Sudden Death Genomics Laboratory, told CNN.
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It isn't enough to have the recessive Charlie and the hard-as-nails Linda — who are looked down on by the Roma as gaje, outside of the tribe — finally decide to fight back against Fonso and his dragon-lady mother (Isabella Rossellini).
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My dad has blue eyes, but it's apparently a recessive trait in my family — both my sister and I are brown-eyed — though the image of the man I may or may not have been was clearly blue-eyed, albeit with brown hair. 3.
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Mr. Bennett was a recessive presence several years ago in the London premiere of the Broadway musical "Once," but his casual appeal works perfectly here, allowing for an element of surprise when this sandal-wearing troubadour tears into "Gethsemane," Jesus's defining second-act solo.
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"We finally figured it out that it was an autosomal recessive condition where both bad duplications came from both parents, and those children were unfortunate to get the double dose," Michael Ackerman, director of the Windland Smith Rice Sudden Death Genomics Laboratory, told CNN.
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All of these groups have estimated founder effects about 10 times as strong as those of Finns and Ashkenazi Jews, which suggests the South Asian groups have "just as many, or more, recessive diseases," said Dr. Reich, who is of Ashkenazi Jewish heritage himself.
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Audience members can submerge themselves in everything from the brassy manipulations of a little old matchmaker named Dolly (embodied by a little old diva named Bette) to the more recessive mysteries of humanity according to American theater's patron saint of the inarticulate, Annie Baker.
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They do not like being short and hate being described as dwarfs, but the recessive gene behind their stunted growth could prove to be an immensely valuable accident of nature, for they appear to have what most people want: an ability to stave off debilitating diseases.
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One team in the NIH's Clinical Pathophysiology Section researches genetic causes of diseases like LAD, an autosomal recessive disease produced when both I, an Indian woman, and my African-American husband had an error on the same part of the same gene on the same chromosome.
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It has a recessive, lunar beauty compared to the sunny ambition and inventiveness of its predecessors, including her masterpiece (with the self-explanatory title), "The Bridegroom Was a Dog" (2012), and "Memoirs of a Polar Bear" (2016), which followed three generations of a distinguished literary family of polar bears.
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Outstanding loans fell for a sixth month in seven in July, totaling 3.115 trillion real ($963 billion), the report showed "The worst of the credit crunch and the recessive business cycle is probably behind us," said Alberto Ramos, chief Latin America economist with Goldman Sachs Group Inc in New York.
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Indeed, Autumn is such a recessive, cipher-like character — and newcomer Flanigan plays her with such affectless understatement — that it comes as a shock when, in a crucial scene at a women's health clinic, she finally gives in to the welter of emotions that she's kept in check for so long.
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The recessive gene for Canavan, as for the better-known Tay-Sachs disease, crops up most often in the Ashkenazi Jewish population, and Gabi and Zohar found that they were both carriers—meaning that any children they conceived would have a one-in-four chance of being born with the disease.
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