Kaelin showed that mutations in the VHL gene were linked to higher expressions of hypoxia-regulated genes, connecting the VHL gene to the hypoxia response as well.
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They appear to have died of hypoxia, or oxygen starvation.
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This genetic mutation confers resistance to hypoxia, otherwise known as altitude sickness.
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Hypoxia also causes increased production of dopamine, which is associated with pleasure.
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The earliest work of the three Nobel Prize winners, by Semenza of Johns Hopkins University, showed that this increase in EPO during hypoxia was due to a specific part of the EPO gene called the hypoxia-response element (HRE).
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These are the symptoms of hypoxia, when the brain doesn't get enough oxygen.
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Hypoxia can result in dizziness, shortness of breath, organ failure, and sometimes death.
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Because all cells need oxygen to function, hypoxia can have serious consequences, including death.
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A "dead zone" is known in scientific literature as hypoxia, which means low oxygen.
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But confabulation can occur from syphilis, encephalitis, brain tumors, hypoxia, schizophrenia, dementia, and more.
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The T-45 is not the only aircraft causing the military issues with hypoxia.
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This is in accordance with the 85033 state law that makes nitrogen hypoxia, i.e.
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Several studies suggest that chronic hypoxia increases mood disturbances, especially in patients with emotional instability.
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A handful of death penalty states allow nitrogen hypoxia, although the method hasn&apost been used.
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The Air Force told CNN that the pause came after five pilots experienced hypoxia-like symptoms.
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Neither service said whether it had a plan to address hypoxia-related symptoms in other aircraft.
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Hypoxia can be a concern in high-altitude regions, or when a plane loses air pressure.
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She listed the more serious medical issues: sickle cell anemia, hypoxia, third-degree burns and sepsis.
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These genes stave off hypoxia, a dangerous condition that happens when the body is deprived of oxygen.
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First, we finally have an explanation for why Denisovans had a gene variant to stave off hypoxia.
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Nitrogen is one of several inert gases that can cause hypoxia, an oxygen deficiency that causes death.
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Neonatal complications, including preterm birth, low birth weight, and factors related to hypoxia, also come into play.
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That wasa concern, because levels below 16 percent can cause oxygen depletion, a condition known as hypoxia.
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For instance, the Chesapeake Bay has experienced a "dead zone," a result of hypoxia, regularly since 1950.
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Others died from vague conditions like "exhaustion" or accidents that might be related to disorientation from hypoxia.
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While he was under anesthesia, the doctors noticed that he had abnormally low levels of oxygen, called hypoxia.
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Almost every summer since 1985, NOAA has sponsored research and monitoring of hypoxia off the coast of Louisiana.
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Hypoxia occurs in healthy people at high altitude, and also in critical care patients, where it's life threatening.
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Hypoxia results from deficiency in the amount of oxygen delivered to cells and can induce potentially fatal complications.
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Dunham was not aware nitrogen hypoxia had ever been used anywhere in the world to execute a person.
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That is a concern because levels below 16 percent can cause oxygen depletion, a condition known as hypoxia.
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He said he will pursue working to gain the ability to use a gas, nitrogen hypoxia, for executions.
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A 2015 law says the state cannot use nitrogen hypoxia unless the three-drug combination is not available.
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They cited a rash of incidents in which pilots appeared to suffer from oxygen deprivation, known as hypoxia.
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The hypoxia had very little impact on their behavior and longevity, and they had no problems mating later on.
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Alabama, Oklahoma and Mississippi all have laws that allow the use of death by nitrogen hypoxia, or gas chamber.
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Brown said four causes of death were given: pulmonary edema, cerebral hypoxia, subdural hematoma and severe encephalitic cranial trauma.
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He had succumbed to hypoxia, low oxygen levels in the blood, a few minutes after a full-term delivery.
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Such hypoxia, or oxygen deprivation, results in lower production of serotonin by the brain, which can lead to depression.
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This includes additional training for pilots on the dangers of hypoxia and how to recognize symptoms while flying simulator aircraft.
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One reasonable explanation could be the effects of hypoxia, or a deficiency in the amount of oxygen reaching the tissues.
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It's a badge of honor, a miniature version of climbing the seven summits, only without the subzero temperatures or hypoxia.
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Hypoxia hurts the Gulf of Mexico's commercial and recreational fishing industries, which are still recovering from recent hurricanes and oil spills.
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Darcy the Frenchie's blue tongue was an apparent symptom of hypoxia, a condition caused by lack of oxygen to the body.
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You could die within hours of respiratory arrest as your lungs failed to expand and your major organs wilted from hypoxia.
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The Navy has also developed training to make sure pilots recognize the symptoms of hypoxia and understand the appropriate emergency procedures.
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They concluded that temperature-dependent hypoxia—loss of oxygen due to changes in temperature—caused about 70 percent of the losses.
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For Bajau free divers, the lack of oxygen is more acute, so it's less like chronic hypoxia and more like sleep apnea.
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"Cerys had suffered an episode of hypoxia which had caused her severe brain damage," the couple's lawyer, Angus Moon, said in court.
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According to the death certificate, obtained by TMZ, Moore was having severe heath issues due to aspiration pneumonia, hypoxia and diabetes mellitus.
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But "the basic cause, no matter what the mechanism, would have been ... hypoxia," the medical term for insufficient oxygen reaching the brain.
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In the mid-1990s, Dr. Kaelin found that the VHL protein helps remove hypoxia-related compounds from cells when oxygen is abundant.
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In 2014, Congress reauthorized the Harmful Algal Bloom and Hypoxia Research and Control Act, originally passed in 133, to encourage more research.
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The crucial molecule in the system that matches cell physiology to oxygen availability is a protein complex called hypoxia-inducible factor (HIF).
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Ratcliffe established a new laboratory dedicated to hypoxia biology at Oxford University in 1990 and became a full professor there in 1996.
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Autopsies had concluded that the provisional cause of death was a combination of hypoxia - oxygen deprivation - and hyperthermia - overheating - in an enclosed space.
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It was a great idea on paper, but we ditched it because we thought doing that for 15 hours would give people hypoxia.
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"Your brain is now swelling because of the hypoxia, and it has nowhere to go because it's constrained by your skull," Dhillon said.
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You can feel the sizzle of hypoxia running the telephone lines of your body, the war in your head, your muscles turning heavy.
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Last summer, Bourdain told me that she was sleeping in a hypoxia chamber—a device that mimics the oxygen depletion of high altitudes.
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The Navy, too, has been having issues with hypoxia-related incidents, and grounded its T-45 training jets for a time last year.
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The 2018 drop was largely due to a loss in flying hours after hypoxia problems repeatedly grounded the Air Force's T-6 fleet.
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As her suit pressure rapidly drops, hypoxia threatens, and she becomes less and less cogent, her partner gently talks her through the rescue process.
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At a whopping 8,776 square miles (22,730 sq km), it's 4.6 times larger than the target size set by the Gulf Hypoxia Task Force.
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Darcy was treated for hypoxia – a lack of oxygen in the body – by her owner who held the oxygen mask over the dog's face.
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Kaelin noticed that when cancer cells didn't have a working VHL gene, they expressed "abnormally high levels of hypoxia-regulated genes," the committee said.
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The two highest-concern symptoms are "dyspnea" (the feeling of shortness of breath) and "hypoxia" (having a low level of oxygen in your blood).
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Low oxygen levels — also known as hypoxia — trigger a spike in the hormone erythropoietin (EPO), which leads to increased production of red blood cells.
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However, the remaining 7% point to possible longer term changes in genes related to his immune system, DNA repair, bone formation networks, hypoxia, and hypercapnia.
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The Englishman discovered a universal mechanism for detecting and responding to low oxygen levels, known as hypoxia, that has since been found in all cells.
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The United States Federal Aviation Administration reports that hypoxia may cause headaches, nausea, drowsiness, rapid breathing, slurred speech and "diminished thinking capacity," among other problems.
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With all of the breathless headlines of the last two weeks, it is astonishing that the entire city of Washington is not swooning from hypoxia.
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"Hypoxia is a feature of many diseases including heart failure, chronic lung disease and many cancers," Andrew Murray, at the University of Cambridge, told the Guardian.
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However, the remaining 7 percent point to possible longer-term changes in genes related to his immune system, DNA repair, bone-formation networks, hypoxia, and hypercapnia.
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Russell Bucklew, a Missouri death-row prisoner with a rare medical condition, filed a lawsuit in 2015 to make the state execute him by nitrogen hypoxia.
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Dr. Hutchins: The pressure inside the aircraft is higher than the aircraft outside, so passengers can breathe comfortably and don't suffer from altitude sickness, hypoxia, etc.
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Last June, Alabama gave death row inmates 30 days to choose nitrogen hypoxia, which deprives the body of oxygen, as the way they would be executed.
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Sleep difficulties might also lead cognitive problems by causing or exacerbating so-called cerebral hypoxia, or a reduction in oxygen supply in the brain, Xu added.
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Autopsies concluded that the provisional cause of death of the 39 people was a combination of hypoxia - oxygen deprivation - and hyperthermia - overheating - in an enclosed space.
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Autopsies concluded that the provisional cause of death of the 39 people was a combination of hypoxia - oxygen deprivation - and hyperthermia - overheating - in an enclosed space.
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Throughout the 1990s and 2000s, Kaelin, Ratcliffe, and Semenza worked separately to decode the actions of an oxygen-sensitive protein called HIF, for hypoxia inducible factor.
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Alabama is the third state to allow the execution of prisoners by nitrogen hypoxia as an alternative to the three-drug cocktail used in its lethal injections.
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The new findings are important as a first step in developing treatments for intensive care unit patients suffering from hypoxia, or a lack of oxygen, Murray says.
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What's more, the addition of nitrogen vapors in a closed room decreases the total amount of oxygen, which can lead to oxygen deficiency (hypoxia), and cause unconsciousness.
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The sound of the naturally aspirated engine as it was pushed to 4583,2458 rpms, the automotive equivalent of brain hypoxia, survived by only the rarest of cars.
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He introduced legislation last year that would allocate $110 million over five years to research the causes of large algae blooms and hypoxia, which essentially suffocates sealife.
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We have led efforts to increase federal investments in a national integrated system to gather data about rising sea levels, coastal flooding, harmful algal blooms, and hypoxia.
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Air Force pilots of the trainer aircraft reported an average of eight hypoxia-related episodes per month between February and July 2018, Aviation Week reported in August.
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And in fact, the researchers are hoping that their findings can be used to develop new treatments for both high-altitude hypoxia and sleep disorders like sleep apnea.
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Scientists say the findings not only help explain Sherpas' mountain-climbing prowess — they may also lead to new ways of treating oxygen deficiencies, called "hypoxia," in hospital patients.
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" According to Moran's March testimony, determining the cause of these incidents has been complicated by the fact that "symptoms related to depressurization, tissue hypoxia and contaminant intoxication overlap.
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Navy and Air Force pilots on various aircraft have been reporting unexplained incidents of hypoxia, which is when the body is deprived of oxygen at the tissue level.
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Paul Johal briefs students in the altitude hypobaric chamber about familiarizing themselves with the oxygen equipment for hypoxia training at Wright-Patterson Air Force Base, Ohio, April 26, 2017.
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The Air Force's F-22 fighter pilots also struggled with hypoxia-like symptoms back in 2012, which led to limitations on F-22 flights until the issue was resolved.
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The 235th Fighter Wing at Luke Air Force Base in Arizona suspended all F-218A flights Friday after the five pilots experienced hypoxia-like symptoms, Air Force spokesman Capt.
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The Air Force's F-22 fighter pilots also struggled with hypoxia-like symptoms back in 2012, which led to limitations on F-22 flights until the issue was resolved.
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According to the death certificate, obtained by TMZ, the contributing factors to her death last week were aspiration pneumonia, hypoxia (lack of oxygen to her tissues) and diabetes mellitus.
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While hypoxia is problematic, both the Air Force and the Navy point to uncontrolled cockpit-pressurization changes as a potentially greater threat to pilots than the air they breathe.
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Though these operate with a co-pilot to backup the captain, there have been instances of both pilots being taken ill—for instance with hypoxia caused by insufficient oxygen.
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The 28.5th Fighter Wing at Luke Air Force Base in Arizona suspended all F-235A flights last week after the five pilots experienced hypoxia-like symptoms, Air Force spokesman Capt.
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The aim of this research was to identify how different people adapt to low oxygen levels -- or hypoxia -- at high altitude and to apply this understanding to critically ill patients.
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Because of where ketamine interacts in the brain, it has some neuroprotective qualities—it can slow down the death of neurons from threats like a lack of oxygen, called hypoxia.
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In May and June 20173, five F-22017A pilots assigned to Luke Air Force Base in Arizona reported "hypoxia-like symptoms" while flying but managed to land their planes safely.
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Inert gas asphyxiation, or hypoxia, whether it be from nitrogen, argon, helium, and methane, reduce concentrations of oxygen in the blood when a person is subjected to an oxygen-poor environment.
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The interviews in Meru describe the mix of techniques required to shift between hiking and wall-climbing, and the potentially insurmountable obstacles: frostbite, hypoxia, running out of food, and so forth.
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The 56th Fighter Wing cancelled local flying operations for its F-35A Lightning II fighters after five incidents since May 2 where pilots experienced symptoms similar to hypoxia, or oxygen deprivation.
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In response to the episodes, the Navy has put in place mandatory cabin pressurization testing, environmental control systems pressure port testing and annual hypoxia awareness training for pilots, among other steps.
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An NOAA-funded study by Duke University found that hypoxia in the Gulf in particular drives up the prices of large shrimp, creating an economic ripple effect on seafood markets and consumers.
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The experience of being in a depressurized airplane cabin was replicated for his benefit (and/or terror), triggering hypoxia-like symptoms that left him weak, disoriented, and unable to help save himself.
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As the oxygen saturation levels in his body drops, he begins to experience hypoxia, and you can see how basic human functions (like say, the will to live) just completely stop working.
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We need to improve our understanding of the implications of environmental stressors, such as harmful algal blooms and hypoxia, marine debris, warming and more acidic ocean waters, overfishing, and rising sea levels.
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Such biochemical arrangements almost always rely on feedback loops—and the crucial molecule in the loop that matches cell physiology to oxygen availability is a protein complex called hypoxia-inducible factor (HIF).
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The CO2 induces a state of suspended animation in the insect, called hypoxia, allowing the scientists to take high-resolution 3D scans of live bugs using X-ray micro-computed tomography (micro-CT).
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Death row inmates in Alabama had the choice back in 2018 to elect to "be executed via nitrogen hypoxia" but that Price did not do so, the majority said in the unsigned order.
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But it also temporarily put airlines at odds with U.S. safety law, because it meant that passengers going to the bathroom during a U.S. flight could risk hypoxia in the event of depressurization.
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According to new research funded by NOAA, and led by the Louisiana Universities Marine Consortium (LUMC), 8,776 square miles of water in the northern Gulf of Mexico is in a state of hypoxia.
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Aphakorn Yoo-kongkaew said oxygen levels in the cave had dropped to 15%, a level that one Thai medic said posed a serious risk of hypoxia, the same condition that causes altitude sickness.
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In 2017, Oklahoma and Mississippi both authorized the use of "nitrogen hypoxia" as a backup execution method, in case either state is barred from administering lethal injections, according to the Death Penalty Information Center.
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The base canceled local flying operations for its F-35A Lightning II aircraft due to five incidents in which pilots experienced symptoms resembling hypoxia, or oxygen deprivation, Graff said on Friday at the Pentagon.
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Two of these genes, PTGIS and KCTD2000, have been shown in prior studies to be related to low oxygen levels and hypoxia, while VDR is known to play a role in vitamin D metabolism.
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Aphakorn Yoo-kongkaew said oxygen levels in the cave had dropped to 15%, a level that one Thai medic said posed a serious risk of hypoxia, the same condition that causes altitude sickness. Gov.
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As oxygen drops below the lower threshold of the optimal level, the body begins to undergo changes and may face the serious risk of hypoxia, the condition that causes altitude sickness, according to OSHA.
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In June, Alabama gave death row inmates 30 days to choose nitrogen hypoxia, which deprives the body of oxygen, as the way they would be executed, and Mr. Price failed to meet the deadline.
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In the unsigned order, the majority said that death row inmates in Alabama had the choice back in 2018 to elect to "be executed via nitrogen hypoxia" but that Price did not do so.
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And during the T-6 hypoxia groundings in 2018, Goldfein said, AETC used the down time to streamline the undergraduate pilot training syllabus to throw out unnecessary parts and adopt new methods of instruction.
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Roxadustat is the first of a new kind of oral anaemia treatment called a hypoxia-inducible factor prolyl hydroxylase inhibitor that boosts production of red blood cells by mimicking the body's response to high altitude.
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Some research shows that hypoxia, or oxygen deprivation, "entails significant suffering" akin to the pain of a heart attack during which the offender may "begin to drool, urinate, defecate or vomit", remaining conscious all the while.
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Masks are meant to drop from the ceiling, which then supply passengers with oxygen from a gas cylinder to prevent hypoxia — the loss of oxygen to the body that can lead to organ damage within minutes.
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But he also offered, as a possible alternative, execution by nitrogen hypoxia, an inert gas that causes rapid death and that death-penalty states are adopting as an alternative to the increasingly unavailable lethal injection drugs.
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Meanwhile, the side effects of dry cabin air and the mild, usually harmless hypoxia that comes from being in a pressurized airplane cabin — dry skin, headaches, dehydration — are likely to be amplified by the longer flight time.
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The 56th on Friday canceled local flying operations for its F-35A Lightning II fighters for the weekend, after five incidents since May 2 in which pilots experienced symptoms similar to hypoxia, also known as oxygen deprivation.
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"Carbon monoxide is a known toxicant which causes hypoxia, or oxygen deprivation, which has several well-known and well-studied detrimental effects on pregnancy and offspring development," Bonn-Miller, who wasn't involved the study, said by email.
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It's not immediately clear how voluntary measures to rectify the situation are actually going to shrink the Gulf Zone's dead zone to an annual average of 1,900 square miles, a goal set by the Gulf Hypoxia Task Force.
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Dunham added the eight Alabama inmates also may "prefer the unknown risks of nitrogen hypoxia to the known risks" of lethal injection drugs while Alabama avoids having to litigate the lethal-injection issue by voluntarily dismissing the case.
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They said that a lack of oxygen can lead to hypoxia, or oxygen deprivation, and affect fundamental processes of the brain, like the production of the neurotransmitter serotonin, which is thought to play a key role in mood.
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The court declined to take up the case of Alabama inmate Christopher Lee Price, who had requested that he be executed by nitrogen hypoxia, in which an individual breathes pure nitrogen until they suffocate, rather than lethal injection.
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Oklahoma Attorney General Mike Hunter said in a statement that the state would use nitrogen hypoxia – asphyxiation by breathing in the inert gas – as its primary means of execution once a protocol had been finalized for the process.
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Looking to Mars Mason's work shows that one of the most important changes to Kelly's cells was hypoxia, or a deficient amount of tissue oxygenation, probably due to a lack of oxygen and high levels of carbon dioxide.
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"As you know, in Oklahoma, a bill that was signed back in 2015 by the governor states that if lethal injection is held unconstitutional or is unavailable, an execution shall be carried out by nitrogen hypoxia," Attorney General Mike Hunter said.
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Stretching from the coast of Louisiana at the Mississippi River Delta westward to the shores of Texas, the area of severe hypoxia — when the water is so depleted of oxygen that it can't sustain fish and marine life — encompasses 8,776 square miles.
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In the late 1980s, Dr. Semenza, a pediatric geneticist at Johns Hopkins, and Dr. Ratcliffe, a kidney specialist at Oxford, began independently researching how oxygen deprivation, or hypoxia, prompts the production of a hormone that elicits red blood cell production to combat it.
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The two circumstances are not the same -- the Thai children face hypoxia and death, and are trapped in a cave that could stay flooded till October -- but the world is pulling for them and mobilizing from every corner of the earth to help.
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Airline and hospital officials haven't said whether anyone experienced hypoxia when the flight -- en route from New York to Dallas with 144 passengers and five crew members -- lost pressurization after part of the Boeing 737-700's engine shot through a cabin window.
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The heavy rains, he added, can be expected to lead to a larger-than-average zone of hypoxia — an area of low or depleted oxygen where life cannot be sustained, commonly called a dead zone — in the Gulf of Mexico this summer.
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In March, Oklahoma announced that its lack of lethal injection drugs left it with no choice but to change its preferred method of execution to "nitrogen hypoxia," which involves depriving prisoners of oxygen and has never been used in any state- or nation-sanctioned execution.
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Strassman suggested that the overlap between DMT and NDEs could possibly be explained on a biological level since DMT is naturally produced in small quantities by the human body and has been shown to minimize neuronal damage due to hypoxia (insufficient oxygen) in test tubes.
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The agency's scientists also predicted that the chemical runoff from the rains would cause above-average hypoxia conditions — "dead zones" of water with low oxygen caused by nutrient pollution that can kill fish and other marine life — in the Gulf of Mexico and Chesapeake Bay.
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For Justice Stephen Breyer, whose dissent was joined in large part by Justices Ruth Bader Ginsburg, Elena Kagan and Sonia Sotomayor, faulting Mr Bucklew "for failing to provide guidance about the administration of nitrogen hypoxia down to the last detail" imposes a novel requirement that "today's majority invents".
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We respond to oxygen starvation, or hypoxia, by triggering a hormone in the kidneys that sends a signal to the body to pump out more, larger red blood cells, which in turn cart more oxygen out from the lungs and into the muscles and organs, giving them a boost.
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They are also continuing to study how pilots in their trainer and combat aircraft are being affected by hypoxia — a physiological condition caused by low levels of oxygen in the bloodstream that can lead to a lack of concentration and muscle control, inability to perform delicate tasks and ultimately loss of consciousness.
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Sitting at the flight engineer's panel, Barnes determined the aircraft's cabin air pressure was stable as the aircrew initiated the 1C-5M-1 or "Dash 1" checklist for a "Pressure Door Unlocked Indication" that directed the aircraft be descended below 10,000 feet to reduce the chances of hypoxia and ensure the safety of aircrew and passengers.
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