Misogyny has meant that periods are ubiquitously tabooed, belittled and euphemized.
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Ubiquitously, this has become a standard relationship ritual and a community building act.
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Lin-Manuel Miranda is about as ubiquitously popular as it's possible to be.
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In China, it's no secret that mass surveillance is ubiquitously intrusive and widespread.
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"Conversion therapy is still happening," he said, calling it "ubiquitously condemned" and "incredibly harmful".
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The Cronut was fetishized, then scorned for being fetishized, then imperfectly and ubiquitously reproduced.
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Because in the cyber context, intrusive infiltrations are questionable often and done almost ubiquitously.
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Each computing platform becomes more ubiquitously accessible and natural for us to interact with.
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He will be missed but fortunately he can be seen ubiquitously on 'Law & Order' reruns.
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These avatars, while likely to spread ubiquitously à la Bitmoji before them, are limited in scope.
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Despite how fervently and ubiquitously the topic is discussed, no one actually likes to discuss cultural appropriation.
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One day drones will ubiquitously operate in our airspace preventing disasters and making our lives safer, easier, and better.
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Furthermore, computer systems of that era weren't ubiquitously connected to networks that offered access to attackers from around the world.
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SAN FRANCISCO — Digital ads pop up online so frequently and ubiquitously that many people are using software to block them.
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For stories alluding to a pain that runs so ubiquitously through our community—like assault, or damaging relationships—it cuts even deeper.
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The party collapsed so ubiquitously last year partly because it does not have any socio-economic base on which to fall back.
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Adams then painted that shape to resemble locally mined marble which is ubiquitously used as stone steps in older row houses in Baltimore.
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Since its release in 2015, the thinking face emoji has been ubiquitously used as a symbol for sarcasm or response to ironic statements.
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After all, if our senses were being systematically and ubiquitously deceived, whether by demon or daemon, we would have no way of knowing.
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These forward thinking developers and advocates will redefine our perception of possibility and continue and lend to a more ubiquitously accessible gaming landscape.
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But if I make all the products ubiquitously available, priced reasonably the same and they all taste great, ultimately it's a consumer choice.
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"Wherever you have impecunious young people ubiquitously connected to the internet, e-commerce is desperate to happen," Ledgard wrote in a concept manifesto.
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With smartphones at near peak performance and owned ubiquitously in much of the world, some analysts say the iPhone has just about hit its ceiling.
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But games in which you play the protector almost ubiquitously cast women as morally unimpeachable angels, whose frail goodness and optimism must be ruthlessly preserved.
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For the voter, that early turnout data is now ubiquitously covered in the news media, adding a new dynamic to the campaign horse race punditry.
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It is humorous to host these conversations in a mall food court: a space initially conceived as public, but ubiquitously encroached upon and dictated by the private.
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For the most part, the vote will be an exercise in stage-managed democracy, with favoured candidates from the ruling United Russia party ubiquitously sailing to victory.
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Once we're all armed with powerful smartphones and ubiquitously fast Internet there will be no limits to the genuinely important reportage that will flow, we were told.
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The bottom line: Platforms that are used ubiquitously by most Americans are all using different opaque ranking systems to evaluate the trustworthiness of news sites and sources.
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Autonomy is great for all sorts of reasons, but from a security perspective it means that the effects of attacks can take effect immediately, automatically, and ubiquitously.
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Given its struggle to stay solvent, let alone relevant, in a ubiquitously digital world, we would do well to liberalize our mail and cut the Postal Service loose.
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Once AEVs — whether buses, cars, trucks, or marine vehicles — start charging themselves, transportation becomes like a perpetual motion machine, a ubiquitously available service that requires little human interaction.
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And while farts can ubiquitously permeate the air into which they are released, metaphorically touching every unsuspecting nostril in the area, that doesn't really count, according to a lawyer.
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That may be because Hoover was once used more ubiquitously as a synonym for a vacuum cleaner (à la Xerox and Kleenex) and not just a brand of vacuum.
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While HelloPay is hardly as ubiquitously used in Southeast Asia as Alipay is in China, the merger should pave the way for Alibaba's plans to spread Alipay outside of China.
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"This is ubiquitously on the mind of everyone at Harvard," said Daniel Banks, the undergraduate council vice president, who helped organize the recent town-hall-style meeting on the subject.
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The move reflects the deep competition both face from Apple's Siri and Google's Assistant and the fact that Alexa and Cortana have been strong in a sphere, but not used ubiquitously.
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Biden noted that physics and aerospace scientists do so, sharing "complex information seamlessly and ubiquitously all the time, but somehow, I guess for 100 years of tradition, not in medicine," Biden said.
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Which means that many of us are now seeing a glut of news from around the world faster — and more ubiquitously, because social platforms are also where our friends live — than ever.
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Mr. Halperin, a ubiquitously televised Washington insider, lost network contracts and a book deal in October after several women accused him of abuse while working at ABC News more than a decade ago.
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As Katy and her friends triumph and fall in ubiquitously fabulous outfits, the show takes on the feeling of watching an especially woke child act out grown-up scenes with Barbie and her friends.
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This rod has been recreated by the artist and placed throughout the installation to good effect, recalling to mind the bâton that the insouciant French conceptual artist André Cadere ubiquitously utilized in the 63s.
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Meanwhile, the High Line looms ubiquitously overhead, like a people mover transporting tourists (mostly) from the new Hudson Yards on the north end to the gleaming Whitney Museum of American Art on the south.
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And the biggest among them are 72,000-pound semitrailers, like the ones commissioned by Titleist, TaylorMade, Callaway and nearly a dozen other golf brands, ubiquitously looming in the background for all the tinkerers on tour.
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Well, let me think, so I think in order to answer the question directly, I would have to agree that the Clintons ignore the law ubiquitously, which I don't necessarily, which I don't agree with.
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Users of the CGM could use the manufacturer's receiver for monitoring or, they expected, their smart phone – a device that has become a ubiquitously used part of the landscape in meetings, restaurants, and at social events.
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It's not clear exactly what would have happened, but it could have had dchilling effect on the very principles of how modern code is written with relation to APIs, which are used ubiquitously and as a standard.
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As a reference point, the street value of Vietnam's most famous sandwich—a baguette spread with pork, pâté, and pickled vegetables—is ubiquitously a dollar or less in Ho Chi Minh City, still known locally as Saigon.
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Ubiquitously permeating the corner of your view like a forgotten stye, these compilations have always been there: occasionally jolting into your consciousness when you notice they've been prominently displayed in a Tesco superstore for the last three decades.
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But, in classic Google fashion, the Mountain View company is doing so at a formidable pace, and it stands a good chance of eventually surpassing Amazon with the help of network effects from its other ubiquitously used services.
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While mobile money services like M-Pesa have been ubiquitously successful in Kenya and neighboring countries, countries like Nigeria — Africa's largest economy — still have significant cost of cash problems and expensive policy restrictions on the use of cash.
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The first three of these "division algebras" would soon lay the mathematical foundation for 20th-century physics, with real numbers appearing ubiquitously, complex numbers providing the math of quantum mechanics, and quaternions underlying Albert Einstein's special theory of relativity.
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Unless there is an ecosystem in which bitcoin is accepted ubiquitously in an underbanked person's world, is a regulated and trusted form of value and is easily accessible, it will mean very little to those without access to financial services.
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If he were using his son's or daughter's likeness as the logo (à la the Wendy's franchise), I could understand how that might be fine, though I'd wonder how his offspring might react later to seeing his cartoon image plastered ubiquitously.
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The vehicle will be communicating constantly — within itself, with other vehicles, with small cell technology that will be deployed ubiquitously, and eventually with the overall infrastructure of our roads including traffic lights, bridges, and street signs (check out this preview).
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And if it's something as ubiquitously photographed as, say, the Roman Forum, all a future Googlephone would need to know are the cloud formations and Sun position at the particular time of the shot, and it'd have enough data to synthesize a photo.
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These are two men who are beloved in the heavy music world for their impish grins so ubiquitously plastered on their faces, so when there's even a hint of darkness in their sound, it's sure to get people to sit up and notice.
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In some public places like airport or shopping malls, specialized bleeding control kits that contain hemostatic bandages and tourniquets might be available, but they are not as ubiquitously stocked as automated external defibrillators, which are used to treat people with heart arrhythmias.
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More than 1,000 applications have been built on the OS, with OpenFin now deployed on more than 200,000 desktops — a noteworthy milestone given that the ever-popular Bloomberg Terminal, which is ubiquitously used across financial institutions and investment firms, is deployed on roughly 300,000 desktops.
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To achieve this, voting machine vendors should be ubiquitously employing an advanced data protection and encryption model that will protect all sensitive voter information — both while it is stored on databases and/or voting machines and while this same information is being sent to and from these systems.
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"We have to take on the gun lobby," she tells voters even as Republican politicians pander in fear of the N.R.A. Mr. Trump, proudly bearing the N.R.A.'s endorsement, dares to invoke fantasies of a ubiquitously armed citizenry ready to draw in self-defense "shootouts" — this in a nation reeling from gun violence.
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"Facebook and Microsoft are prominent names and you would think that they'd be able to put the market on their shoulders and pull it higher, but 3M is a little more indicative of the global economy because its products are sold ubiquitously," said Mark Luschini, chief investment strategist at Janney Montgomery Scott in Philadelphia.
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He painted archetypes rescued and blended from both universal and iconoclastic mythologies — mothers and kings, torturers, bound and flayed captives, fish and birds, hybrid creatures, himself, his wife, friends and strangers, who gather with a spectrum of props: costumes, masks, stringed and brass instruments, formal dress, and most ubiquitously, a lit cigarette in hand.
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Inspired by a classic meme genre (photoshopping well-known artwork) and what we're now ubiquitously referring to as "social distancing" (the strategy we're all adopting to contain the spread of COVID-19) Hyperallergic took works by some of our favorite artists and reimagined what they would look like during these, um, sparsely populated times.
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If you have seen the following scene from Sanjuro (1962) in which Toshino Mifune bisects Tatsuya Nakadai, or any of the one hundred thousand shots it influenced across every sword fight in every movie or anime you have ever seen, you are the target audience for Samurai Shodown (2019), a reboot of the series you may remember from the arcade machines of your youth, which featured ubiquitously on SNK's Neo-Geo hardware.
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This gene is ubiquitously expressed in adult and fetal tissues.
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This encoded protein is known as the D subunit and is found ubiquitously.
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FAM78B is generally ubiquitously expressed and is highly expressed in regions of the brain.
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The human EMK1 was shown to be encoded by a single mRNA ubiquitously expressed.
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EVI5L has ubiquitously low expression, with slightly higher expression in the testis and fetal brain.
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MIPOL1 is ubiquitously expressed at low levels in humans, with highest expression in the prostate.
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BLOC-3 or biogenesis of lysosome-related organelles complex 3 is a ubiquitously expressed multisubunit protein complex.
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C21orf58 ortholog in mouse 2610028H24Rik was found to be ubiquitously expressed at high levels throughout the mouse brain.
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C2orf27 is ubiquitously expressed in most tissues but with increased expression in the brain, pancreas, kidneys, and testis.
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Very few people refer to it as Grantham North, and is ubiquitously known as the Gonerby Moor Service Area.
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The cathepsin F gene is ubiquitously expressed, and it maps to chromosome 11q13, close to the gene encoding cathepsin W.
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ThTr-2 is a ubiquitously expressed transmembrane thiamine transporter that lacks folate transport activity. It is specifically inhibited by chloroquine.
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NRF2 is ubiquitously expressed with the highest concentrations (in descending order) in the kidney, muscle, lung, heart, liver, and brain.
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GEO Profile of CCDC92 expression in humans. The blue dots indicate the percentile at which the protein was expressed in that tissue compared with all other proteins. In humans, CCDC92 is expressed ubiquitously at a medium to high level (shown right). In dogs and mice, it is expressed ubiquitously, however at significantly lower levels.
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Throughout the body, BZW2 is ubiquitously expressed within tissues. There is elevated mRNA abundance in the heart, placenta, and skeletal muscle.
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Aeromonas species are Gram-negative, rod-shaped, non-spore-forming, facultatively anaerobic bacteria that occur ubiquitously and autochthonously in aquatic environments.
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Tissue where FAM83H has been found, as well as concentration FAM83H is ubiquitously expressed throughout the human body at relatively low levels.
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CDV3 is ubiquitously expressed, and at relatively high levels, in all tissues examined in the humans. Higher expression existed in certain diseases.
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C7orf25 protein UPF0415 is believed to be active in ATP dependent protein breakdown in the proteosome pathway. It is expressed ubiquitously in humans.
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There is little to no expression data available for the gene, but most indications point to it being ubiquitously expressed throughout the body.
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Other neurotransmitters such as acetylcholine and dopamine have multiple sources in the brain but are not as ubiquitously distributed as glutamate and GABA.
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SMAC is ubiquitously expressed in many cell types, implicating it in various biological processes involving apoptosis. Currently, nonapoptotic functions for SMAC remain unclear.
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SAAL1 is ubiquitously expressed at moderate levels across all human tissues with highest expression in testes as determined by RNA-sequencing and microarray expression profiling.
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Microarray tissue expression patterns from GEO were analyzed and showed that CCDC47 appears to be an ubiquitously expressed at moderate levels in many different human tissues. Although the protein is ubiquitously expressed, the highest levels of expression are seen in neuronal tissues such as the superior cervical ganglion, brain amygdala and ciliary ganglion. Elevated expression is also seen in the thyroid and CD34+ cells.
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Pseudomonas luteola is an opportunistic pathogen, found ubiquitously in damp environments. Originally designated in the genus Chryseomonas, the species has since been reassigned to the genus Pseudomonas.
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Expression TMEM8A TMEM8A is found to be expressed ubiquitously throughout the human body; however, it has been shown to be downregulated during CD4+ and CD8+ T-cell activation.
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Granin (chromogranin and secretogranin) is a protein family of regulated secretory proteins ubiquitously found in the cores of amine and peptide hormone and neurotransmitter dense-core secretory vesicles.
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MKK7 is ubiquitously expressed in all tissue. However, it displays a higher level of expression in skeletal muscle. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found.
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Protein UXT (Ubiquitously eXpressed Transcript protein) also known as androgen receptor trapped clone 27 (ART-27) protein is a protein that in humans is encoded by the UXT gene.
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As a result, it is ubiquitously used in the source tristimulus signal, the R'G'B' input. Examples of such color spaces include sRGB, the TV Rec. 601, Rec. 709, and Rec.
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Expression data from expressed sequence tag mapping, microarray and in situ hybridization shows EVI5L has ubiquitously low expression. However, it has slightly higher expression in the testis and fetal brain.
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FAM163A is ubiquitously expressed at very low levels in most tissues of the body; expression is higher in juveniles, and as previously seen, in chronic smokers' lungs and neuroblastoma cells.
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Cytoglobin is a ubiquitously expressed hexacoordinate hemoglobin that may facilitate diffusion of oxygen through tissues, scavenge nitric oxide or reactive oxygen species, or serve a protective function during oxidative stress.
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No concrete data is present establishing ATG101 in any particular area. By looking at multiple expression sets in both humans and mice, it has been hypothesized to be ubiquitously expressed in tissues.
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C1orf74 is ubiquitously expressed in most tissues in humans during embryonic development and through adulthood. This gene is expressed throughout the nervous system, mammary and salivary glands, skin, and most internal organs.
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PRCC1 is ubiquitously expressed, with high- density expression in the brain, hypothalamus and hippocampus in particular. No evidence of protein-protein interactions were found. No evidence of RNA alternate splicing was determined.
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TCTP is a 20–25 kDa protein abundantly and ubiquitously expressed in the cell. The protein is transcribed in more than 500 different tissues and cell types; hTCTP gene is one of the top 10 most ubiquitously expressed genes in humans by examining 1753 libraries from kinds of tissues, but differed considerably in their quantity and ratio of expression. The expression is lower in kidney and renal cells. This indicates an extensive transcriptional control and involvement of tissue-specific factors.
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Cheap Prosecco is also sold in cans. In Italy, Prosecco is a ubiquitously used wine. Outside Italy, it is most often drunk as an apéritif. As with other sparkling wines, Prosecco is served chilled.
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Furthermore, brain slices show glutamate receptors are ubiquitously expressed in both developing and mature astrocytes and oligodendrocytes in vivo. Because of this, glial glutamate receptors are thought to be vital for glial cell development.
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Biocides are oxidizing or non-oxidizing toxicants. Chlorine is the most commonly manufactured oxidizing toxicant. Chlorine is ubiquitously added to drinking water to disinfect it. Non-oxidized toxicants include isothiazolinones and quaternary ammonium compounds.
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Close homologues have been found in plants, earthworm, Caenorhabditis elegans (F52H2.11), Hydra, Saccharomyces cerevisiae (YKL056c) , Schizosaccharomyces pombe (SpAC1F12.02c) and protozoa like Trypanosoma brucei . Mammalian TCTP is ubiquitously expressed in various tissues and cell types.
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The Korea Times, a news organization based in Seoul, carries a significant presence in Fort Lee Koreatown. The Record of Bergen County, published by North Jersey Media Group, is also ubiquitously available in Koreatown.
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Domain (amino acids 373 to 403). This protein is found ubiquitously in vivo in significant quantities and can be detected in all fluid compartments. During acute phase inflammatory response, DBP levels tend to increase.
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Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. The boule-like protein appears to be ubiquitously expressed in males of all animal species, except in the most primitive trichoplax.
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Though ubiquitously expressed, ankyrin-B shows high expression levels in cardiac muscle, and is expressed 10-fold lower levels in skeletal muscle, suggesting that ankyrin-B plays a specifically adapted functional role in cardiac muscle.
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He then named this earthworm after Pheretima praepinguis in 1935. Although Yi Chen insisted that Pheretima praepinguis is a synonym of Pheretima tschiliensis in an article published in 1936, this name is ubiquitously accepted nowadays.
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Lysine-specific demethylase 6A also known as Ubiquitously transcribed tetratricopeptide repeat, X chromosome (UTX), is a protein which in humans is encoded by the KDM6A gene. It belongs to the 2-oxoglutarate (2OG)-dependent dioxygenase superfamily.
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EST profiling of NBPF19 shows it to be ubiquitously expressed in most human tissues at unremarkable amounts. It is expressed in relatively higher amounts in the skin, lymphoid organs (lymph nodes, spleen) and the gonads (ovary, testes).
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The mRNAs of these proteins are expressed ubiquitously in human adult and fetal tissues. Several alternatively spliced transcript variants of this gene have been described, but the full- length nature of some variants has not been determined.
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This gene encodes a transmembrane protein, which is located primarily in the endoplasmic reticulum and ubiquitously expressed with highest levels in brain, pancreas, heart, and insulinoma beta-cell lines. Wolframin appears to function as a cation-selective ion channel.
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MAP11 has a widespread moderate expression with tissue to tissue variability in humans and across mammalian species. The mouse C7orf43 ortholog has been shown to be ubiquitously expressed in the brain, as well as in the mouse embryonic central nervous system.
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There is distant conservation seen in organisms such as zebra finches and anoles. SOGA2 is ubiquitously expressed in humans, with especially high expression in brain (especially the cerebellum and hippocampus), colon, pituitary gland, small intestine, spinal cord, testis and fetal brain.
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Furthermore, it plays a key role in immune and angiogenic responses. CD47 is ubiquitously expressed in human cells and has been found to be overexpressed in many different tumor cells. Expression in equine cutaneous tumors has been reported as well.
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The blue signifies naval ties, while the scarlet and gold are the official Marine Corps colors. They appear ubiquitously in the Marine Corps, particularly on signage. They also form the base colors of the flag of the United States Marine Corps.
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CD8+ T cells that are specific for a MiHA can target these antigens when they are expressed specifically on tumor cells, which allows for the destruction of harmful tumor cells. In mice, allogeneic stem cell transplantation donor CD8+ T cells specific for a MiHA found in the recipient has been shown to inhibit the division of leukemic cells. However, there is a risk in developing GVHD if the T cells are specific for MiHAs expressed ubiquitously on epithelial cells. More specifically, HA-8, UGT2B17 and SMCY MiHAs that are ubiquitously expressed present a higher risk of developing GVHD.
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In human, GTPBP3 is ubiquitously expressed in multiple tissues in multiple transcripts. As a tRNA modification enzyme, it is thought to function to modify codon-anticodon interaction, which is consistent with its modification of the severity of phenotypes in 12S rRNA A1555G mutation..
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Mfrn1 is paralogous to Mitoferrin-2 (Mfrn2), a 39 kDa protein encoded by the SLC25A28 gene in humans. Mfrn1 is highly expressed in differentiating erythroid cells and in other tissues at low levels, while Mfrn2 is expressed ubiquitously in non-erythroid tissues.
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Lectins occur ubiquitously in nature. They may bind to a soluble carbohydrate or to a carbohydrate moiety that is a part of a glycoprotein or glycolipid. They typically agglutinate certain animal cells and/or precipitate glycoconjugates. Most lectins do not possess enzymatic activity.
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TSBP1 is ubiquitously expressed at low levels in the adult human genome. In adults, expression of this gene is highest in the testis. C6orf10 is expressed at higher levels in fetal and embryonic tissues. This indicates C6orf10 may play a role in development.
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Expression of a chimeric transcript of LAZ3 and this gene has been reported as a result of the translocation t(3;4) in non-Hodgkin's lymphomas. Unlike most other small G proteins which are expressed ubiquitously, this gene is transcribed only in hemopoietic cells.
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Interleukin-10 receptor is a type II cytokine receptor. The receptor is tetrameric, composed of 2α and 2β subunits. The α subunit is expressed on haematopoietic cells (such as T, B, NK, mast, and dendritic cells) whilst the β subunit is expressed ubiquitously.
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Because PTB is ubiquitously expressed in many higher eukaryotes, it is thought to suppress the inclusion of "weak" exons with poorly defined splice sites.Wagner EJ, Garcia-Blanco MA. (2001). Polypyrimidine tract binding protein antagonizes exon definition. Mol Cell Biol 21(10):3281-3288.
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ATXN2 is conserved across eukaryotes. Most vertebrates have two orthologs of the gene (called ATXN2 and ATXN2L in humans), with the exception of birds which only have one. Plant species have two to six ATXN2 orthologs. ATXN2 is ubiquitously expressed in different tissues.
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Specifically, PNKD-L is only expressed in the central nervous system whereas PNKD-M and PNKD-S are ubiquitously expressed across tissues. Moreover, PNKD-L localizes to the cell membrane, PNKD-S to the cytoplasm and nucleus, and PNKD-M to the mitochondrion.
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RNA-seq experiments from the GTEx project found that TMEM81 is ubiquitously expressed in humans but shows enhanced expression in the cerebellum and cerebellar hemisphere.GTEx portal entry on TMEM81 Other tissues and organs showing somewhat enhanced mRNA expression include the testis and spleen.
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In some cases, no PEST sequence at all is seen. This leads to the no proteosomal destruction of the protein. The NOTCH2 gene is ubiquitously expressed in all embryonic tissue. When researching HCS in mice, the homozygous deletion of NOTCH2 leads to death.
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C11orf1 appears to be ubiquitously expressed at low levels but particularly high expression in the parathyroid. Expression data indicate expression in most tissues. This gene has also been found in one experiment to be under expressed in Huntington's disease patients while SETDB1 is over-expressed.
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Many cases of malignant carcinoids and lymphomas were negative. In all these tests, only a single antibody was used (CAB034331).The Human Protein Atlas entry on C8orf82 Microarray data has shown C8orf82 to be ubiquitously expressed. Microarray data for C8orf82 throughout normal human tissues.
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CHID1 is expressed ubiquitously at levels nearly 6 times the average gene, and is conserved very far back to organisms such as Caenorhabditis elegans and possibly some prokaryotes. This protein is known to have carbohydrate binding sites, which could be involved in carbohydrate catabolysis.
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Three mammalian homologues have been characterized, which all differ in their ability to function as adaptor proteins due to the differing lengths of their C-terminal UBA domains: # c-Cbl: ubiquitously expressed, 906 and 913 amino acids in length in humans and mice respectively # Cbl-b: ubiquitously expressed, 982 amino acids long. # Cbl-c: lacks the UBA domain and is therefore only 474 amino acids in length. It is primarily expressed in epithelial cells however its function is poorly understood. Both c-Cbl and Cbl-b have orthologues in D. melanogaster (D-Cbl) and C. elegans (Sli-1), hinting at a long evolutionary path for these proteins.
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Naturally occurring read-through transcripts, resulting from intergenic splicing between this gene and an immediately upstream gene (PPAN, encoding peter pan homolog), have been found. The PPAN-P2RY11 read-through mRNA is ubiquitously expressed and encodes a fusion protein that shares identity with each individual gene product.
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Functional ADAM17 has been documented to be ubiquitously expressed in the human colon, with increased activity in the colonic mucosa of patients with ulcerative colitis, a main form of inflammatory bowel disease. Other experiments have also suggested that expression of ADAM17 may be inhibited by ethanol.
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500 The term "abstracting" occurs ubiquitously in Science and Sanity. Korzybski's use of the term is somewhat unusual and requires study to understand his meaning. He discussed the problem of identification in terms of "confusions of orders of abstractions" and "lack of consciousness of abstracting".Korzybski, Alfred.
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TMEM156 is expressed in several tissues including ascites, bone marrow, salivary glands, and vascular to name a few. This gene is not ubiquitously expressed, but is still evident in many tissues. This gene is predominately expressed in adults but there is a bit of expression in fetuses.
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Philosophische Vortrdge und Aufsdtze. Ed. H. Horz and S. Wollgast. Berlin: Akademie-Verlag. Although the accuracy of Goethe's observations does not admit a great deal of criticism, his aesthetic approach did not lend itself to the demands of analytic and mathematical analysis used ubiquitously in modern Science.
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Nectins and Nectin-like molecules (Necl) are families of cellular adhesion molecules involved in Ca2+-independent cellular adhesion. Nectins are ubiquitously expressed and have adhesive roles in a wide range of tissues such as the adherens junction of epithelia or the chemical synapse of the neuronal tissue.
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SMCO4 is not ubiquitously expressed throughout humans. There is evidence that the expression of SMCO4 is easily manipulated by many different factors, making constant expression unlikely. One example of this expression regulation comes from an experiment that showed increased SMCO4 expression in the presence of Gamma-tocotrienol.
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Brevibacterium linens is a gram-positive, rod-shaped bacterium. It is the type species of the family Brevibacteriaceae. Brevibacterium linens is ubiquitously present on the human skin, where it causes foot odor. The familiar odor is due to sulfur-containing compounds known as S-methyl thioesters.
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GEO Profile for the expression of the human protein CCDC180 in normal tissues. CCDC180 is expressed ubiquitously at low levels throughout the body, and the highest expression is consistently seen to be in the testes. Other replicated tissues of high expression include the trachea and eye.
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Research of VRACs has led some to conclude that they are widely expressed in mammalian cells and that they may even be ubiquitously expressed. VRACs have also been shown to participate in fundamental cellular processes other than basic volume regulation, such as cell proliferation, migration, and apoptosis.
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Cytoglobin is the protein product of CYGB, a human and mammalian gene. Cytoglobin is a globin molecule ubiquitously expressed in all tissues and most notably utilized in marine mammals. It was discovered in 2001 and named cytoglobin in 2002. It is thought to protect against hypoxia.
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COX4I1 is located on the q arm of chromosome 16 in position 24.1 and has 6 exons. The COX4I1 gene produces a 9.3 kDa protein composed of 83 amino acids. COX4I1 is expressed ubiquitously. The protein encoded by COX4I1 belongs to the cytochrome c oxidase IV family.
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CHID1 is located on chromosome 11 at the location p15.5. It is just downstream of TSPAN4 and upstream of AP2A2. CHID1 is ubiquitously expressed at a high levels. Through microarray analysis, it has been shown that CHID1 is generally expressed at 5.7 times the average gene.
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In the fictional Mass Effect universe dark energy fields are used ubiquitously to modify mass of objects, e.g. of weapon projectiles to allow use of compact mass accelerators in order to achieve higher muzzle velocity, or even negate the mass of entire spaceships in order to enable FTL travel.
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The isozymes have 87-88% identical amino acid sequence identity and though they are structurally and functionally similar, they have different localizations: PGK2, encoded by an autosomal gene, is unique to meiotic and postmeiotic spermatogenic cells, while PGK1, encoded on the X-chromosome, is ubiquitously expressed in all cells.
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The 70 kilodalton heat shock proteins (Hsp70s or DnaK) are a family of conserved ubiquitously expressed heat shock proteins. Proteins with similar structure exist in virtually all living organisms. The Hsp70s are an important part of the cell's machinery for protein folding, and help to protect cells from stress.
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Centre Place, Melbourne. Australia is considered the birthplace of the "flat white". In Australia, coffee shops are ubiquitously known as cafés. Since the post- World War II influx of Italian immigrants introduced espresso coffee machines to Australia in the 1950s, there has been a steady rise in café culture.
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It is 360 amino acids in length. It is expressed ubiquitously but only in G1/S phase of the cell cycle. The human and mouse mRNAs of this protein have 77% homology. Two types of amino acid clusters have been observed, a serine cluster and a basic cluster.
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The Korea Times, a news organization based in Seoul, carries a significant presence in the Long Island Koreatown. All of the major New York City daily newspapers are also found ubiquitously in Koreatown, including The New York Times, Newsday, the New York Daily News, and the New York Post.
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The CALU gene encodes a deduced 315-amino acid protein containing 6 EF-hand motifs, 1 potential N-glycosylation site, and a C-terminal ER retention signal. The human and mouse CALU proteins are 98% identical. CALU mRNA is ubiquitously expressed in human tissues and maps to 7q32.
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WIPF1 has an N-terminal profilin binding domain, two actin binding WH2 domains, a central polyproline stretch, and a C-terminal WASP Binding Domain. WASp protein is degraded in the absence of WIP; however, the ubiquitously expressed WASp ortholog N-WASp remains stable in the absence of WIP.
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This gene encodes a protein which is capable of interacting with the major nonstructural protein of parvovirus H-1 and 70-kDa heat shock cognate protein; however, its function is not known. Since this transcript is expressed ubiquitously in various tissues, this protein may serve a housekeeping function.
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There are several lines of evidence that suggest the C6orf222 protein is expressed non- ubiquitously in select tissue locations at low levels, including the ascites, bladder, intestine, testes, vagina, lymph nodes and skin. The ascites and bladder displayed the strongest expression with 25 and 66 transcripts per million, respectively.
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In particular, HK3 is ubiquitously expressed in tissues, albeit at relatively low abundance. Higher abundance levels have been cited in lung, kidney, and liver tissue. Within cells, HK3 localizes to the cytoplasm and putatively binds the perinuclear envelope. HK3 is the predominant hexokinase in myeloid cells, particularly granulocytes.
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TMEM69 is expressed ubiquitously at low levels throughout the human body, although EST Profile data reveal that TMEM69 is expressed particularly high in neuroendocrine tissues such as the liver, amygdala, hippocampus, and hypothalamus. TMEM69 was found to be expressed in lower than normal values in patients suffering from atherosclerosis.
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F. Riesz's theorem (named after Frigyes Riesz) is an important theorem in functional analysis that states that a Hausdorff topological vector space (TVS) is finite-dimensional if and only if it is locally compact. The theorem and its consequences are used ubiquitously in functional analysis, often used without being explicitly mentioned.
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Villin is an actin binding protein expressed mainly in the brush border of the epithelium in vertebrates but sometimes it is ubiquitously expressed in protists and plants. Villin is found localized in the microvilli of the brush border of the epithelium lining of the gut and renal tubules in vertebrates.
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OCC-1 (overexpressed in colon carcinoma-1) is a protein, which in humans is encoded by the gene C12orf75. The gene is approximately 40,882 bp long and encodes 63 amino acids. OCC-1 is ubiquitously expressed throughout the human body. OCC-1 has shown to be overexpressed in various colon carcinomas.
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During the peak of Nintendo's success in the video game industry in the 1990s, their name was ubiquitously used to refer to any video game console, regardless of the manufacturer. To prevent their trademark from becoming generic, Nintendo pushed usage of the term "game console", and succeeded in preserving their trademark.
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This gene is one of two genes that encode the V1 domain C subunit proteins and is found ubiquitously. This C subunit is analogous but not homologous to gamma subunit of F-ATPases. Previously, this gene was designated ATP6D. In melanocytic cells ATP6V1C1 gene expression may be regulated by MITF.
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Proteins of this family may also be involved in non-cell cycle-related functions, such as neurocytoskeleton dynamics. The exact function of this protein has not yet been determined. It has unusually large N- and C-termini and is ubiquitously expressed in many tissues. Two alternatively spliced variants are described.
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Ubiquitin is a small (8.6 kDa) regulatory protein found in most tissues of eukaryotic organisms, i.e., it is found ubiquitously. It was discovered in 1975 by Gideon Goldstein and further characterized throughout the 1970s and 1980s. Four genes in the human genome code for ubiquitin: UBB, UBC, UBA52 and RPS27A.
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ZCCHC18 ubiquitously expresses in ovary, brain (cerebellum), endometrium, lymph node, spleen and 22 other tissues in human and other species. Based on RNA-Seq expression data from GTEx (53 tissues from 570 donors), highest median expression is in brain—cerebellum (4.74 RPKM) whereas the total median expression of 67.54 RPKM.
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The copula -i- in Korean is ubiquitously found in presumed ‘Sluicing’ and ‘Fragment’ constructions. The copula denotes the equative relation between the subject and the complement of the copula. In (8), through the assumed equative relation, the complement of the copula describes the ‘categorial membership’ of the subject. (8) a.
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TMEM126A is expressed ubiquitously throughout the human body at 1.8 times the normal expression level for human genes. It experiences especially high expression in the parathyroid gland. In addition, TMEM126A experiences higher levels of expression in peripheral blood cells in patients diagnosed with Huntington's disease as well as individuals who experience ocular dominance.
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The protein was found to be expressed in numerous different tissues. The ETS Profile for TMEM268 indicates the gene is expressed ubiquitously within the body. In support, there has been experimental evidence using antibody staining to show various tissue types that express TMEM268. A recent study linked TMEM268 as a lysosome transporter.
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A Finnish long drink, made by combining gin and grapefruit soda. In Finland, "lonkero" refers to a mixed drink made from gin and, most commonly, grapefruit soda, although other long drink flavours include cranberry and lime. In Finland, the long drink is ubiquitously available both in stores and in restaurants, usually on draught.
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CARKD appears to be ubiquitously expressed at high levels. Expression data in the human protein, and the mouse ortholog, indicate its expression in almost all tissues. One peculiar expression pattern of CARKD is its differential expression through the development of oligodendrocytes. Its expression is lower in oligodendrocyte progenitor cells than in mature oligodendrocytes.
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Later, TRP channels were found in vertebrates where they are ubiquitously expressed in many cell types and tissues. Most TRP channels are composed of 6 membrane-spanning helices with intracellular N- and C-termini. Mammalian TRP channels are activated and regulated by a wide variety of stimuli and are expressed throughout the body.
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As a member of the FASTKD family, FASTKD1 localizes to the mitochondria to modulate their energy balance, especially under conditions of stress. Though ubiquitously expressed in all tissues, FASTKD1 appears more abundantly in skeletal muscle, heart muscle, and other tissues enriched in mitochondria. FASTKD1 has been validated as an RNA-binding protein.
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According to the National Center for Biotechnology Information, C2CD4D has only been found to be expressed in adult individuals with some form of cancer.National Center for Biotechnology Information C2CD4D is not ubiquitously expressed, and thus far scientists have only found C2CD4D expressed in the tissues of the brain, intestine, and mammary gland.
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Ras GTPase-activating-like protein IQGAP1 (IQGAP1) also known as p195 is a ubiquitously expressed protein that in humans is encoded by the IQGAP1 gene. IQGAP1 is a scaffold protein involved in regulating various cellular processes ranging from organization of the actin cytoskeleton, transcription, and cellular adhesion to regulating the cell cycle.
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Human ubiquitin, wild-type (). The N-terminal beta strand is the second from top, pointing right; the C-terminal strand is the one in front, pointing right and downwards. The exchangeable amino acids are located at the top left. Ubiquitin, as the name suggests, is a highly conserved protein occurring ubiquitously in eucaryotes.
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TCTP protein is also referred to as Q23, P21, P23, histamine releasing factor (HRF), and fortilin. TCTP is a multifunctional and highly conserved protein that existed ubiquitously in different eukaryote species and distributed widely in various tissues and cell types. Human translationally controlled tumor protein (hTCTP) is a growth-related, calcium-binding protein.
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The protein encoded by this gene is a ubiquitously expressed nuclear protein. It binds directly, with several other proteins, to retinoblastoma protein which regulates cell proliferation. It was formerly known as Retinoblastoma Binding Protein 2 (RBP2). This protein also interacts with rhombotin-2 which functions distinctly in erythropoiesis and in T-cell leukemogenesis.
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The function of PLEKHM3 is not characterized in any scientific database. It is thought to be associated with cell differentiation and is expressed at ubiquitously low levels in all cell types. The Pleckstrin Homology domains are involved with phosphate binding. The DUF4206 Domain is cysteine rich and forms with 7 CXXC protein motifs.
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The protein encoded by this gene is a ubiquitously expressed nuclear protein and belongs to a highly conserved subfamily of WD- repeat proteins. It is found among several proteins that bind directly to retinoblastoma protein, which regulates cell proliferation. The encoded protein interacts preferentially with the underphosphorylated retinoblastoma protein via the E1A-binding pocket B.
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Perfluorinated compounds are used ubiquitously: For example, fluorosurfactants are widely used in the production of teflon (PTFE) and related fluorinated polymers. They confer hydrophobicity and stain-resistance to fabrics. They are components of fire-fighting foam. Fluorosurfactants (PFAS) reduce surface tension by concentrating at the liquid-air interface due to the lipophobicity of polyfluorocarbons.
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This implied that these TSSs are regulated separately, despite being within close proximity. Ubiquitously expressed promoters had the highest conservation in their sequences, while cell-specific promoters were less conserved. A further prominent result suggested that enhancer-derived RNA (eRNA) are transcribed in a cell/tissue specific manner, reflective of the activity of that enhancer.
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Telomerase-binding protein EST1A is an enzyme that in humans is encoded by the SMG6 gene on chromosome 17. It is ubiquitously expressed in many tissues and cell types. The C-terminus of the EST1A protein contains a PilT N-terminus (PIN) domain. This structure for this domain has been determined by X-ray crystallography.
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Basic Leucine Zipper and W2 Domain-Containing Protein 2 is a protein that is encoded by the BZW2 gene. It is a eukaryotic translation factor found in species up to bacteria. In animals, it is localized in the cytoplasm and expressed ubiquitously throughout the body. The heart, placenta, skeletal muscle, and hippocampus show higher expression.
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The protein product of ABHD18 in humans is predicted to be a secreted product. It is ubiquitously expressed at low to moderate levels. In humans, the protein is found at high levels the digestive tract and parathyroid gland. The homologous mouse protein 3110057O12Rik is expressed at high levels in the granule layer of the cerebellum.
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SHOC1 is ubiquitously expressed in most tissues with higher than average expression in the testes, the kidney, the thymus, and the adrenal gland. The promoter for SHOC1 Isoform 1 in humans is 639 bp long and overlaps with the 5’ untranslated region of the gene. There are four alternate promoters that promote different transcript variants.
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Expressed sequence tag mapping of TMEM229B gene expression indicates that it is ubiquitously expressed throughout the body. TMEM229B is more heavily expressed in the parathyroid, skin, and thyroid tissues, and moderately expressed in bone marrow, trachea, spleen, eye, brain, pancreas, mammary gland, intestine, liver, thymus, lymph node, ovarian, muscle, lung, blood, and kidney tissues.
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KAP1 is a ubiquitously expressed protein involved in many critical functions including: transcriptional regulation, cellular differentiation and proliferation, DNA damage repair, viral suppression, and apoptosis. Its functionality is dependent upon post-translational modifications. Phosphorylation of KAP1 acts as a deactivator of the protein in many of its mechanisms while sumoylation acts as an activator.
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Since JAK3 is not as ubiquitously expressed, selective targeting could improve tolerability, and decrease possible adverse effects and safety concerns. For example, dual inhibition of JAK1 and JAK3 might increase bacterial and viral infection because of a broader immunosuppressive effect. Inhibition of JAK2 has been linked to adverse effects such as anaemia and generalised leukopenia.
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WIPF1 has been shown to interact with Wiskott-Aldrich syndrome protein, N-WASp, Cortactin, NCK1, MYO1e and ITSN1. While Wiskott-Aldrich syndrome protein is expressed only in haematopoetic cells, WIPF1 is expressed ubiquitously. Majority of the mutations causing Wiskott Aldrich Syndrome are located in the WH1 domain of WASp. These mutations affect WASp-WIPF1 binding.
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Exon 1B lies 6 kb upstream of exon 2 within the large first intron of the ubiquitously expressed PGM1 transcript. The fast-muscle form of PGM1 is characterized by 18 extra amino acid residues at its N-terminal end. Sequence comparisons show that exons 1A and 1B are structurally related and have arisen by duplication.
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Message passing is key to some models of concurrency and object-oriented programming. Message passing is used ubiquitously in modern computer software. It is used as a way for the objects that make up a program to work with each other and as a means for objects and systems running on different computers (e.g., the Internet) to interact.
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The results show not only that modularity formed ubiquitously in the models that factored in connection cost, but that these models also outperformed the performance-only based counterparts in every task. This suggests a potential model for module evolution whereby modules form from a system’s tendency to resist maximizing connections to create more efficient and compartmentalized network topologies.
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GEO Profile expression analysis of ZNF280D protein in human tissues. ZNF280D is ubiquitously expressed at relatively low levels throughout almost all tissues in the human body. In one study, the expression of ZNF280D was compared between endothelial progenitor cells in cord blood and peripheral blood. The results show that expression was significantly higher in cord blood.
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Melanoma-associated antigen D2 is a protein that in humans is encoded by the MAGED2 gene. This gene is a member of the MAGED gene family. While the MAGEA and MAGEB genes are silent in normal tissues with the exception of testis and placenta, the MAGED genes are expressed ubiquitously. The MAGED genes are clustered on chromosome Xp11.
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A disintegrin and metalloproteinase with thrombospondin motifs 7 (ADAMTS7) is an enzyme that in humans is encoded by the ADAMTS7 gene on chromosome 15. It is ubiquitously expressed in many tissues and cell types. This enzyme catalyzes the degradation of cartilage oligomeric matrix protein (COMP) degradation. ADAMTS7 has been associated with cancer and arthritis in multiple tissue types.
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HIKESHI was determined to be expressed ubiquitously at a high level of 2.3 times above the average. C11orf73 is expressed in a large number of human tissues. Between the Expression Profiles and the EST Profile on UniGene, only 11 tissues were shown not to express C11orf73, most likely due to small sample sizes in the tissue.
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The protein encoded by this gene is a ubiquitously expressed nuclear protein. It binds directly, with several other proteins, to retinoblastoma protein (pRB) which regulates cell proliferation. pRB represses transcription by recruiting the encoded protein. This protein, in turn, serves as a bridging molecule to recruit HDACs and, in addition, provides a second HDAC-independent repression function.
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The four gene cluster of BH11940, BH11950, BH11960, and BH11970 are all proteins of unknown function transcribed on the sense strand and encoded by the same promoter. The promoter is ubiquitously conserved in the other Bartonella species and contains a TATA box. BH11960 is the largest of the four proteins. File:Bh11960.jpg#file Bartonella henselae: BH11960”.
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NO CARRIER is a response message that is defined in the Hayes command set. Due to the popularity of Hayes modems during the heyday of dial-up connectivity, most other modem manufacturers supported the Hayes command set. For this reason, the NO CARRIER message was ubiquitously understood to mean that one was no longer connected to a remote system.
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Ribosome biogenesis protein WDR12 is a protein that in humans is encoded by the WDR12 gene on chromosome 2. It is ubiquitously expressed in many tissues and cell types. WDR12 participates in ribosome biogenesis and cell proliferation as a component of the PeboW complex. This protein is associated with cardiovascular diseases such as coronary artery disease and myocardial infarction.
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Location of TMEM33 on human chromosome 4 In humans, this gene’s DNA location is the short arm of chromosome 4, loci position: 4p13. The genomic range is 41937502-41956213, spanning 18.7 kb, on the positive strand. Transmembrane protein 33 is ubiquitously expressed, but is particularly highly expressed in the blood, lymph nodes, bone, and adipose tissue.
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It has been shown that aphthous stomatitis is more common in people using toothpastes containing SLS, and that some reduction in ulceration occurs when a SLS-free toothpaste is used. Some have argued that since SLS is almost ubiquitously used in oral hygiene products, there is unlikely to be a true predisposition for aphthous stomatitis caused by SLS.
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5α-R1 and 5α-R2 appear to be expressed in the prostate in male fetuses and throughout postnatal life. In adulthood, 5α-R1-3 is ubiquitously expressed. 5α-R1 and 5α-R2 are also expressed, although to different degrees in liver, genital and nongenital skin, prostate, epididymis, seminal vesicle, testis, ovary, uterus, kidney, exocrine pancreas, and the brain.
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Par17Mueller JW, Kessler D, Neumann D, Stratmann T, Papatheodorou P, Hartmann-Fatu C, Bayer P. (2006). Characterization of novel elongated Parvulin isoforms that are ubiquitously expressed in human tissues and originate from alternative transcription initiation. BMC Molecular Biology, 7:9. Kessler D, Papatheodorou P, Stratmann T, Dian EA, Hartmann-Fatu C, Rassow J, Bayer P, Mueller JW. (2007) .
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Those expression levels must be compared to each other. Gierman et al. (2007) were the first who proved co- regulation using this approach. As an insertion construct they used a fluorescing GFP gene driven by the ubiquitously expressed human phosphoglycerate kinase (PGK) promoter. They integrated this construct in 90 different positions in the genome of human HEK293 cells.
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Jasmine gave name to the jasmonate plant hormones, as methyl jasmonate isolated from the oil of Jasminum grandiflorum led to the discovery of the molecular structure of jasmonates. Jasmonates occur ubiquitously across the plant kingdom, having key roles in responses to environmental cues, such as heat or cold stress, and participate in the signal transduction pathways of many plants.
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This suggests that overexpression of ZIP family genes that encode cation transporters is a characteristic genetic feature of hyperaccumulation. Another gene family that has been observed ubiquitously in hyperaccumulators are the ZTP and ZNT families. A study on T. caerulescens identified the ZTP family as a plant specific family with high sequence similarity to other zinc transporter4.
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This gene encodes a ubiquitously expressed transcription factor that controls cholesterol homeostasis by stimulating transcription of sterol-regulated genes. The encoded protein contains a basic helix-loop-helix leucine zipper (bHLH-Zip) domain. Various single nucleotide polymorphisms (SNPs) of the SREBF2 have been identified and some of them are found to be associated with higher risk of knee osteoarthritis.
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A consensus secondary structure and primary sequence for the targets of the AUF1 RNA binding protein. This gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are nucleic acid binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). The interaction sites on the RNA are frequently biased towards particular sequence motifs.
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One isoform, Grx2a, localizes to the mitochondria, is ubiquitously expressed in tissues (e.g. heart, skeletal muscle, kidney, and liver), regulates mitochondrial redox homeostasis, and protects cells against oxidative stress. Isoforms Grx2b and Grx2c, both localized to the nucleus and cytosol, are expressed only in testes and cancer cell lines and facilitate cellular differentiation and transformation, potentially inducing tumor progression.
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The encoded protein shares 100% sequence identity with the mouse counterpart. This gene is ubiquitously expressed, with high expression seen in adult muscle. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. Ube2g2 is known to interact with a variety of other proteins, including ubiquitin, the E3 gp78, and the Hrd1 RING.
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From Unigene's EST cDNA tissue abundance display (see Figure 8), C3orf70 is non-ubiquitously expressed and has relatively low expression levels with slightly higher expression levels seen in the brain. Also, microarray data profile GDS426 (see Figure 9) showing the expression of C3orf70 across normal tissues displays a notably high presence in the brain, spinal cord, and prostate tissue.
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C7ORF30 is located on chromosome 7 in humans and runs from 23,305,465 to 23,315,705. There are four predicted exons in the human gene with conservation occurring across most mammalian species. There is no conclusive data regarding whether the gene is ubiquitously expressed in human tissues, but expressed sequence tag databases show that it is expressed in many tissues.
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ID1 has been shown to interact weakly with MyoD but very tightly with ubiquitously expressed E proteins. E proteins heterodimerize with tissue restricted bHLH proteins such as Myod, NeuroD, etc. to form active transcription complexes so by sequestering E proteins, Id proteins can inhibit tissue restricted gene expression in multiple cell lineages using the same biochemical mechanism. Other interacting partners include CASK.
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Integrated production sites are characterized by co-location of a large number of individual production lines (producing a specific chemical), which share an interconnected material flow. Piping is used ubiquitously for volume materials. All production lines use common raw material sourcing and feed back waste resources, which can be used elsewhere (e.g. steam of various temperatures, sulfuric acid, carbon monoxide).
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According to his death certificateHenri Biva death certificate, Avis de Décès, Dossier : LH/246/1, Leonore, Culture.gouv.fr (avis de décès), Biva died 2 February 1929 at his home in Paris, 72 rue du Château-d'Eau. The date of death for Biva of 1928 found ubiquitously on the Internet is erroneous. As his death certificate testifies, he actually died in 1929.
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Retrieved on 2014-03-10. "New York Headquarters 141-07 20th Ave. Whitestone, NY 11357" Numerous other Chinese- and English-language publications are available in Flushing, including SinoVision, one of North America's largest Chinese language television networks. The popular styles of Chinese cuisine are ubiquitously accessible in Flushing, including Hakka, Taiwanese, Shanghainese, Hunanese, Szechuan, Cantonese, Fujianese, Xinjiang, Zhejiang, and Korean Chinese cuisine.
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There is 99.97% likelihood that PRR21 enters the mitochondria. PRR21 may be involved in stress responses that are related to phosphorylation of mitochondrial proteins. The gene is ubiquitously expressed, as nearly all eukaryotic cells contain mitochondria. PRR21 may be a salivary protein, as the tandemly repeated sequence constitute almost the entire protein, which is a common feature of salivary proline-rich proteins.
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FAM71E1, also known as Family With Sequence Similarity 71 Member E1, is a protein that in humans is encoded by the FAM71E1 gene. It is thought to be ubiquitously expressed at low levels throughout the body, and it is conserved in vertebrates, particularly mammals and some reptiles. The protein is localized to the nucleus and can be exported to the cytoplasm.
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Acyl-coA acyltransferase-related enzyme 2 required for viability is a protein that in humans is encoded by the ARV1 gene. It is involved in lipid trafficking. ARV1 is ubiquitously expressed in higher eukaryotes, and in Saccharomyces cerevisiae yeast, is required for viability. Arv1-/- knockout mice display a phenotype with reduced white adipose and favorable blood lipid profiles on a chow diet.
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The rock of the cave and the Brevibacterium linens bacteria which developed in it, the constant temperature and humidity, act on the cheeses produced here. Brevibacterium linens is ubiquitously present on the human skin, where it causes foot odour. The same bacterium is also employed to ferment several cheeses such as Limburger, Port- du-Salut and Năsal. Its smell also attracts mosquitoes.
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Today, hand pressing—a method demonstrated to tourists—is taught only as a technique preserved as a part of the Japanese cultural tradition. Most of the ubiquitous vending machines also carry a wide selection of both hot and cold bottled teas. Oolong tea enjoys considerable popularity. Black tea, often with milk or lemon, is served ubiquitously in cafes, coffee shops, and restaurants.
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Glycosylphosphatidylinositol anchor attachment 1 protein is a protein that in humans is encoded by the GPAA1 gene. Posttranslational glycosylphosphatidylinositol (GPI) anchor attachment serves as a general mechanism for linking proteins to the cell surface membrane. The protein encoded by this gene presumably functions in GPI anchoring at the GPI transfer step. The mRNA transcript is ubiquitously expressed in both fetal and adult tissues.
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Letharia is an eye catching genus of fruticoseSharon Eversman, "Lichens in Yellowstone Park", Plan Your Visit, National Park Service lichen belonging to the suborder Lecanorineae,C.J. Alexopolous, Charles W. Mims, M. Blackwell, Introductory Mycology, 4th ed. (John Wiley and Sons, Hoboken NJ, 2004) distributed ubiquitously on all continents except Antarctica. There were historically two species of Letharia: L. vulpina and L. columbiana.
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Myotonic dystrophy (MD) is most noticeably caused by inheriting an unstable CTG triplet expansion in the DMPK gene. In healthy genotypes two isoforms of an insulin receptor mRNA transcript exist. The isoform IR-A lacks exon 11 and is expressed ubiquitously in cells. Isoform IR-B contains exon 11 and is expressed in cells of the liver, muscles, kidney, and adipocytes.
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As a cyclophilin, PPI binds cyclosporin A (CsA) and can be found within in the cell or secreted by the cell. In eukaryotes, cyclophilins localize ubiquitously to many cell and tissue types. In addition to PPIase and protein chaperone activities, cyclophilins function in mitochondrial metabolism, apoptosis, immunological response, inflammation, and cell growth and proliferation. PPIE in particular also exhibits RNA-binding activity.
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Sphingosine-1-phosphate (S1P) receptors are divided into five subtypes: S1PR1, S1PR2, S1PR3, S1PR4 and S1PR5. They are expressed in a wide variety of tissues, with each subtype exhibiting a different cell specificity, although they are found at their highest density on leukocytes. S1PR1, 2 and 3 receptors are expressed ubiquitously. The expression of S1PR4 and S1PR5 are less widespread.
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The WRKY transcription factor family is ubiquitously present in the green plant lineage. Most algae contain one or a few WRKY proteins, whereas even the earliest land plant, moss (Physcomitrella patens), possesses at least 30 WRKY factors. Most vascular plants contain in excess of 50 WRKY transcription factors. Outside of plant WRKY proteins have been identified in Giardia lamblia and Dictyostelium discoideum.
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A calpain (; , ) is a protein belonging to the family of calcium-dependent, non-lysosomal cysteine proteases (proteolytic enzymes) expressed ubiquitously in mammals and many other organisms. Calpains constitute the C2 family of protease clan CA in the MEROPS database. The calpain proteolytic system includes the calpain proteases, the small regulatory subunit CAPNS1, also known as CAPN4, and the endogenous calpain-specific inhibitor, calpastatin.
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RNF113A translates a human protein 343 amino acids long and molecular weight of 38.8 kiloDaltons. The protein is found ubiquitously in the human body.Identification of a new member (ZNF183) of the Ring finger gene family in Xq24-25 Yeast Two Hybrid Screens link RNF113A with other proteins. Most of these proteins are currently known to function in the human Spliceosome.
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The non- proteinogenic amino acid beta-Methylamino-L-alanine (BMAA) is ubiquitously produced by cyanobacteria in marine, freshwater, brackish, and terrestrial environments. The exact mechanisms of BMAA toxicity on neuron cells is being investigated. Research suggests both acute and chronic mechanisms of toxicity. BMAA is being investigated as a potential environmental risk factor for neurodegenerative diseases, including ALS, Parkinson's disease and Alzheimer's disease.
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Hemibagrus is a genus of catfishes (order Siluriformes) of the family Bagridae. The genus Hemibagrus is known from Southeast Asia, India, and southern China. Members of this genus are found ubiquitously in river drainages east of the Ganges-Brahmaputra basin and south of the Yangtze basin, and reach their greatest diversity in Sundaland. This genus consists of large- sized catfishes.
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This gene is ubiquitously expressed and encodes a full-length protein which has an N-terminal BTB domain followed by a BACK domain and six kelch-like repeats in the C-terminus. These kelch-like repeats promote substrate ubiquitination of bound proteins via interaction of the BTB domain with the CUL3 (cullin 3) component of a cullin-RING E3 ubiquitin ligase (CRL) complex.
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A visual depiction of MARCM In order to label small populations of cells from a common progenitor, MARCM uses the GAL4-UAS system. A marker gene such as GFP is placed under control of a UAS promoter. GAL4 is ubiquitously expressed in these flies, thus driving marker expression. In addition, GAL80 is driven by a strong promoter such as tubP.
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In modern days, dill is used in salads, soups, sauces, and fish and vegetable dishes. In Santa Maria, Azores, dill (endro) is the most important ingredient of the traditional Holy Ghost soup (sopa do Espírito Santo). Dill is found ubiquitously in Santa Maria, yet curiously, is rare in the other Azorean Islands. In Sweden, dill is a common spice or herb.
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Claviceps spp. fungus growing on wheat spikes, a common endophyte of the grasses. The fungal endophytes are a diverse group of organisms forming associations almost ubiquitously throughout the plant kingdom. The endophytes which provide indirect defense against herbivores may have come from a number of origins, including mutualistic root endophyte associations and the evolution of entomopathogenic fungi into plant- associated endophytes.
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The ROCK isoforms are encoded by two different identified genes and are ubiquitously expressed. GTPase-RhoA binding can increase the activity of ROCK1 by 1.5-2-fold. Without RhoA binding, lipids such as arachidonic acid or sphingosine phosphorylcholine can increase ROCK1 activity 5- to 6-fold. These two lipids interact with the pleckstrin-homology domain, thus disrupting its ability to inhibit ROCK1.
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This protein is a ubiquitously expressed nuclear protein and belongs to a highly conserved subfamily of WD-repeat proteins. It is found among several proteins that binds directly to retinoblastoma protein, which regulates cell proliferation. The encoded protein is found in many histone deacetylase complexes, including mSin3 co-repressor complex. It is also present in protein complexes involved in chromatin assembly.
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Crystal structure of Trypsin, a typical serine protease. Serine proteases (or serine endopeptidases) are enzymes that cleave peptide bonds in proteins, in which serine serves as the nucleophilic amino acid at the (enzyme's) active site. They are found ubiquitously in both eukaryotes and prokaryotes. Serine proteases fall into two broad categories based on their structure: chymotrypsin-like (trypsin-like) or subtilisin-like.
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The WASL gene product is a homolog of WAS protein, however, unlike the latter, it is ubiquitously expressed and shows highest expression in neural tissues. It has been shown to bind Cdc42 directly, and induce formation of long actin microspikes. According to one study, mouse DAB1 regulates actin cytoskeleton through N-WASP. Diseases associated with WASL include Wiskottt-Aldrich Syndrome and Vaccinia.
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This gene product is a 626-amino acid polypeptide that is 96.5% identical to mouse MEKK3. Its catalytic domain is closely related to those of several other kinases, including mouse MEKK2, tobacco NPK, and yeast STE11. Northern blot analysis revealed a 4.6-kb transcript that appears to be ubiquitously expressed. MAP3Ks are involved in regulating cell fate in response to external stimuli.
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The protein encoded by this gene is a ubiquitously expressed nuclear protein. It is found among several proteins that bind directly to retinoblastoma protein, which regulates cell proliferation. This protein complexes with transcriptional co-repressor CTBP. It is also associated with BRCA1 and is thought to modulate the functions of BRCA1 in transcriptional regulation, DNA repair, and/or cell cycle checkpoint control.
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While researchers focused on miRNA expression in physiological and pathological processes, various technical variables related to microRNA isolation emerged. The stability of stored miRNA samples has been questioned. microRNAs degrade much more easily than mRNAs, partly due to their length, but also because of ubiquitously present RNases. This makes it necessary to cool samples on ice and use RNase-free equipment.
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Lumican is a major keratan sulfate proteoglycan of the cornea but is ubiquitously distributed in most mesenchymal tissues throughout the body. Lumican is involved in collagen fibril organization and circumferential growth, corneal transparency, and epithelial cell migration and tissue repair. Corneal transparency is possible due to the exact alignment of collagen fibers by lumican (and keratocan) in the intrafibrillar space.
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This gene encodes a ubiquitously expressed member of the TALE/PBX homeobox family. It was identified by its similarity to a homeobox gene which is involved in t(1;19) translocation in acute pre-B-cell leukemias. This protein is a transcriptional activator which binds to the TLX1 promoter. The gene is located within the major histocompatibility complex (MHC) on chromosome 6.
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Goobies is a village located northeast of Swift Current. It had a population of 98 in 1956, however its population has grown to 194 according to 2007 census estimate. Its main feature is a large statue of a moose at the ubiquitously province-known Irving gas station just outside the main part of the village. Goobies is an unincorporated community.
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CCDC130 is a highly conserved protein, it has orthologous genes in some yeasts and plants that were found using nucleotide and protein versions of the basic local alignment search tool (BLAST) from the National Center for Biotechnology Information. GEO profiles for CCDC130 have shown that this protein is ubiquitously expressed, but the highest levels of expression are found in T-lymphocytes.
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C16orf42 is not expressed ubiquitously in humans. It is most highly expressed in the ovary, but not expressed at all in the blood and very little in the brain.UniGene One microarray experiment suggested that malaria causes its expression in the blood, but further experimentation is needed to support this claim. Its expression in tissues tends to remain constant when the tissue is diseased.
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Human tissue expression Micro arrays show that FAM167A has varied expression in reactions to cancers, but no information regarding the exact function of FAM167A can be drawn from these micro arrays. FAM167A has ubiquitously low expression in all tissues types throughout the body. In mouse it has a higher expression in the skin, B-cells, and spleen, but the same low expression in all other cell types.
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The gene seems to be ubiquitously expressed at low levels throughout the body but has prominent expression in the adult human testis, followed by lower expression levels in the sperm, oocyte, and brain. Age does not have an effect on its expression in the skeletal muscle of males or females. Its expression is elevated prior to the differentiation of embryonic stem cells into pancreatic islet-like cells.
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Although its function is mostly unknown, fukutin is a putative transmembrane protein that is ubiquitously expressed, although at higher levels in skeletal muscle, heart and brain. It is localized to the cis- Golgi compartment, where it may be involved in the glycosylation of α-dystroglycan in skeletal muscle. The encoded protein is thought to be a glycosyltransferase and could play a role in brain development.
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Although there is no expression profile of FAM in early embryos in Xenopus, in the zebra fish, FAM homolog is expressed ubiquitously at a two-cell stage but as development proceeds then its only expressed in the cephalic central nervous system.Khut, P.Y., Tucker, B., Lardelli, M., and Wood, S.A. (2007). Evolutionary and expression analysis of the zebrafish deubiquitylating enzyme, usp9. Zebrafish 4, 95-101.
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The game was generally positively received at the time. The presentation was ubiquitously praised: the visuals were called "magnificent" and "amazing", and frequently compared to those of Myst, although some complained of excessive pixelation. The cutscenes were praised for high video quality. The storyline and atmosphere were called "very good", "interesting and well-developed" and "sublime", with some critics drawing comparisons to Jules Verne novels.
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Isoarborinol is a triterpenoid ubiquitously produced by angiosperms and is thus considered a biomarker for higher plants. Though no isoarborinol- producing microbe has been identified, isoarborinol is also considered a possible biomarker for marine bacteria, as its diagenetic end product, arborane, has been found in ancient marine sediments that predate the rise of plants. Importantly, isoarborinol may represent the phylogenetic link between hopanols and sterols.
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The fact that OPN interacts with multiple cell surface receptors that are ubiquitously expressed makes it an active player in many physiological and pathological processes including wound healing, bone turnover, tumorigenesis, inflammation, ischemia, and immune responses. Manipulation of plasma (or local) OPN levels may be useful in the treatment of autoimmune diseases, cancer metastasis, bone (and tooth) mineralization diseases, osteoporosis, and some forms of stress.
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There indication of multiple sources that suggest, in humans, C5orf34 protein is expressed non- ubiquitously in select tissues at low/moderate levels, with the most abundant expression in the tissues of the stomach, small intestine, testis, skeletal muscle and heart muscle. A study of Rho kinase inhibitor effect on primary cell lines also showed that C5orf34 is expressed in dermal fibroblasts of normal human tissue samples.
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As a member of the FASTKD family, FASTKD3 localizes to the mitochondria to modulate their energy balance, especially under conditions of stress. Though ubiquitously expressed in all tissues, FASTKD3 appears more abundantly in skeletal muscle, heart muscle, and other tissues enriched in mitochondria. FASTKD3 has been proposed to regulate energy production by serving as a scaffold protein that brings together RNA processing/translation and respiratory components.
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Histo-blood group ABO system transferase is an enzyme with glycosyltransferase activity, which is encoded by the ABO gene in humans. It is ubiquitously expressed in many tissues and cell types. ABO determines the ABO blood group of an individual by modifying the oligosaccharides on cell surface glycoproteins. Variations in the sequence of the protein between individuals determine the type of modification and the blood group.
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Jan van Riebeeck's coat of arms The painting of Bartholomeus Vermuyden, thought to be of van Riebeeck instead, which was used on banknotes and coins. Jan van Riebeeck is of cultural and historical significance to South Africa. Many of the Afrikaner population view him as the founding father of their nation. This regard was also prevalent in that his image appeared ubiquitously on stamps.
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Subunit d in V-ATPases, called subunit C in A-ATpases, is a part of the Vo complex. They fit onto the middle of the c ring, so are thought to function as a rotor. There are two versions of this subunit in eukaryotes, d/d1 and d2. In mammals, d1 (ATP6V0D1) is the ubiquitously expressed version and d2 (ATP6V0D2) is expressed in specific cell types only.
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GPX1 is ubiquitously expressed in many tissues, where it protects cells from oxidative stress. Within cells, it localizes to the cytoplasm and mitochondria. As a glutathione peroxidase, GPx1 functions in the detoxification of hydrogen peroxide, specifically by catalyzing the reduction of hydrogen peroxide to water. The glutathione peroxidase also catalyzes the reduction of other organic hydroperoxides, such as lipid peroxides, to the corresponding alcohols.
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S. maltophilia is naturally resistant to many broad-spectrum antibiotics (including all carbapenems) due to the production of two inducible chromosomal metallo-β-lactamases (designated L1 and L2). This makes treatment of infected patients very difficult. S. maltophilia is ubiquitously present in the environment and impossible to eradicate, which makes prevention also extremely difficult. Sensitivity testing requires nonstandard culture techniques (incubation at 30 °C).
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RHEB also known as Ras homolog enriched in brain (RHEB) is a GTP-binding protein that is ubiquitously expressed in humans and other mammals. The protein is largely involved in the mTOR pathway and the regulation of the cell cycle. RHEB is a recently discovered member of the Ras superfamily. Being a relative of Ras, the overexpression of RHEB can be seen in multiple human carcinomas.
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Prohibitins are evolutionarily conserved genes that are ubiquitously expressed. The human prohibitin gene, located on the BRCA1 chromosome region 17q21, was originally thought to be a negative regulator of cell proliferation and a tumor suppressor. This anti-proliferative activity was later attributed to the 3' UTR of the PHB gene, and not to the actual protein. Mutations in human PHB have been linked to sporadic breast cancer.
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The CR7 domain binds TCAB1, which localizes telomerase to cajal bodies, further increasing telomerase catalytic activity. TERC is ubiquitously expressed, even in cells lacking telomerase activity and TERT expression. As a result, various TERT-independent functional roles of TERC have been proposed. 14 genes containing a TERC binding motif are directly transcriptionally regulated by TERC through RNA-DNA triplex formation-mediated increase of expression.
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Alpha- and gamma-adducins are ubiquitously expressed. In contrast, beta-adducin is expressed at high levels in brain and hematopoietic tissues. Adducin binds with high affinity to Ca(2+)/calmodulin and is a substrate for protein kinases A and C. Alternative splicing results in multiple variants encoding distinct isoforms; however, not all variants have been fully described. Polymorphism in ADD1 is associated with hypertension.
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Rice barns are used ubiquitously in the rice cultivating world for the storage and drying of harvested rice. They are prevalent in many Southeast Asian nations, Laos, Cambodia, Thailand and Indonesia among them. In North America rice barns were especially common in the U.S. state of South Carolina.Auer, Michael J. The Preservation of Historic Barns , Preservation Briefs, National Park Service, first published October 1989.
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Dexamethasone-induced Ras-related protein 1 (RASD1) is a protein that in humans is encoded by the RASD1 gene on chromosome 17. It is ubiquitously expressed in many tissues and cell types. As a member of the Ras superfamily of small G-proteins, RASD1 regulates signal transduction pathways through both G proteins and G protein-coupled receptors. RASD1 has been associated with several cancers.
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Heterogeneous nuclear ribonucleoprotein F is a protein that in humans is encoded by the HNRNPF gene. This gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA binding proteins that complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and regulate alternative splicing, polyadenylation, and other aspects of mRNA metabolism and transport.
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UCK1 is expressed ubiquitously in healthy tissue, but found in low levels in tumor tissues. Conversely, UCK2 has been detected mostly in cancerous cells and healthy placental tissue. The selective expression in target tissues has resulted in the identification of UCK2 as a target in anti-cancer therapies. One strategy for anti-cancer and anti-viral therapies involves using UCK2 to activate anti-tumor prodrugs through phosphorylation.
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FH1/FH2 domain-containing protein 1 is a protein that in humans is encoded by the FHOD1 gene. This gene encodes a protein which is a member of the formin/diaphanous family of proteins. The gene is ubiquitously expressed but is found in abundance in the spleen. The encoded protein has sequence homology to diaphanous and formin proteins within the Formin Homology (FH)1 and FH2 domains.
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Collagen alpha-1(IV) chain (COL4A1) is a protein that in humans is encoded by the COL4A1 gene on chromosome 13. It is ubiquitously expressed in many tissues and cell types. COL4A1 is a subunit of the type IV collagen and plays a role in angiogenesis. Mutations in the gene have been linked to diseases of the brain, muscle, kidney, eye, and cardiovascular system.
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Crystal structure of a rotaxane with an α-cyclodextrin macrocycle. Template directed syntheses ubiquitously exist in nature (protein biosynthesis, etc.), which provides inspiration for synthesising artificial supramolecular systems. Using porphyrin monomers/oligomers and molecular templates of various sizes, porphyrin nanoring systems can be constructed with high versatility. These supramolecular systems also bear appealing co- ordination properties, providing inspirations for the co-ordination phenomena existing in nature.
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SNED1 is ubiquitously expressed at intermediate levels, making it unclear from RNA expression profiles, which cells are secreting SNED1. The protein expression profiles of SNED1 predicted with MOPED-Multi-Omics Profiling Expression Database and PaxB-Protein Abundance Across Organisms database indicate that the protein is found in blood serum, blood plasma, blood T-lymphocytes, platelets, kidney Hek-293 cells, liver, and low levels in the brain.
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ALDOA likely regulates actin cytoskeleton remodeling through interacting with cytohesin-2 (ARNO) and Arf6. ALDOA is ubiquitously expressed in most tissues, though it is predominantly expressed in developing embryo and adult muscle. In lymphocytes, ALDOA is the predominant aldolase isoform. Within the cell, ALDOA typically localizes to the cytoplasm, but it can localize to the nucleus during DNA synthesis of the cell cycle S phase.
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They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This gene is ubiquitously expressed, and at higher levels than other TLR genes. Different length transcripts presumably resulting from use of alternative polyadenylation site, and/or from alternative splicing, have been noted for this gene.
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Two years later, in 1988, Peter Agre independently isolated the protein and demonstrated it was a ubiquitously expressed water transport protein, naming it aquaporin. In 2003 Agre would receive the Nobel Prize in Chemistry for his work. Benga and his collaborators would appeal this award before the Nobel Committee, to no avail, though he would receive recognition with a Gold Medal at the Third Science Congress held in Constanța.
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Ankyrin repeat and SAM domain-containing protein 1A (ANKS1A), also known as ODIN, is a protein that in humans is encoded by the ANKS1A gene on chromosome 6. It is ubiquitously expressed in many tissues and cell types. ODIN is known to regulate the epidermal growth factor receptor (EGFR) and EphA receptor signaling pathways. As a Src family kinase target, ODIN has been implicated in the development of cancer.
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This enzyme functions in dephosphorylating nucleoside triphosphates, especially the 5′- and 2′(3′)-phosphates of uracil and thymine, as well as inosine and guanine, dNTPs (dUMPs, dTMPs, dIMPs, and dGMPs, respectively). Due to this function, cdN regulates the size of dNTP pools in cells, in conjunction with the cytosolic thymidine kinases, as part of the dNTP substrate cycle. The enzyme is ubiquitously expressed, though lymphoid cells display particularly high cdN activity.
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Expression of PLD3 in tissues differs with the transcript size of its mRNA. The longer 2200 base pair transcript is ubiquitously expressed in the body, exhibiting higher expression levels in the heart, skeletal muscle, and the brain. Meanwhile, the shorter 1700 base pair transcript is found in abundance in the brain, but at low expression in non-nervous tissue. PLD3 expression is especially pronounced in mature neurons in the mammalian forebrain.
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Lamina-associated polypeptide 2 (LAP2), isoforms beta/gamma is a protein that in humans is encoded by the TMPO gene. LAP2 is an inner nuclear membrane (INM) protein. Thymopoietin is a protein involved in the induction of CD90 in the thymus. The thymopoetin (TMPO) gene encodes three alternatively spliced mRNAs encoding proteins of 75 kDa (alpha), 51 kDa (beta) and 39 kDa (gamma) which are ubiquitously expressed in all cells.
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Heterogeneous nuclear ribonucleoprotein H2 is a protein that in humans is encoded by the HNRNPH2 gene. This gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport.
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VAMP-Associated Protein A ( or Vesicle-Associated Membrane Protein-Associated Protein A) is a protein that in humans is encoded by the VAPA gene. Together with VAPB and VAPC it forms the VAP protein family. They are integral endoplasmic reticulum membrane proteins of the type II and are ubiquitous among eukaryotes. VAPA is ubiquitously expressed in human tissues and is thought to be involved in membrane trafficking by interaction with SNAREs.
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Heterogeneous nuclear ribonucleoprotein A0 is a protein that in humans is encoded by the HNRNPA0 gene. This gene belongs to the A/B subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport.
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This prize is awarded in memory of Marcel Linsman (1912-1989), distinguished University Professor. The prize is usually awarded during an official ceremony taking place in one Belgian university during which two other prestigious prizes in different fields are awarded. Similar to other prestigious prize ceremonies, the recipients deliver a scientific presentation of their research. The reputation achieved by this prize is ubiquitously recognized amongst academics in Europe.
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SH2B adapter protein 3 (SH2B3), also known as lymphocyte adapter protein (LNK), is a protein that in humans is encoded by the SH2B3 gene on chromosome 12. SH2B adapter protein 3 is a protein that in humans is encoded by the SH2B3 gene on chromosome 12. It is ubiquitously expressed in many tissues and cell types. LNK functions as a regulator in signaling pathways relating to hematopoiesis, inflammation, and cell migration.
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Protein salvador homolog 1 is a protein that in humans is encoded by the SAV1 gene. WW domain-containing proteins are found in all eukaryotes and play an important role in the regulation of a wide variety of cellular functions such as protein degradation, transcription, and RNA splicing. This gene encodes a protein which contains 2 WW domains and a coiled-coil region. It is ubiquitously expressed in adult tissues.
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Advances in molecular genetics have enabled identification of most genes associated with HSAN I. However, the molecular mechanisms that underlie the disease are not fully understood and are under investigation. One of challenges in the investigation is to elucidate how faulty genes that are ubiquitously expressed and are involved in basic cellular functions, such as sphingolipid metabolism, maintenance of organellar integrity, membrane dynamics, and transcription regulation, affect specific populations of neurons.
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In some of his paintings, the cult to TV celebrities and movie stars pretends to take over every possible space, reaching a ubiquitously self-centered divinity status. Many of the "retablos" that he has created are paintings distributed in three united plates. These triptychs operate as history books meant to be read carefully 'between the lines'. The lines in this case are the constant commercial interruptions implicit in the message.
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The Scipionic Circle, or the Circle of Scipio, was a group of philosophers, poets, and politicians patronized by their namesake, Scipio Aemilianus.Publius Cornelius Aemilianus Scipio Africanus Minor Together they would discuss Greek culture, literature, and humanism. Alongside their philhellenic disposition, the group also had a more humane Roman foreign policy. The term was first derived during the 19th century and ubiquitously adopted by scholars of the early 20th century.
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Polypyrimidine tract-binding protein 1 is a protein that in humans is encoded by the PTBP1 gene. This gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA-binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport.
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Fam158a is nearly ubiquitously expressed throughout the human body. The homolog in mice also shows expression throughout the entire body. Several micro-arrays demonstrate the variable expression of Fam158a in response to other factors and in various cancer types. None of this information gives any indication of a specific function but the wide expression of the gene and its high conservation indicate that Fam158a plays an important role in cellular function.
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QRICH1 is expressed at a high level, 3.3 times the average gene. It is expressed ubiquitously throughout the human body, although EST Profile data reveal that QRICH1 is expressed particularly high in tissues such as the thymus, testis, cerebellar cortex and other areas of the brain, trachea, and in embryonic tissue. Health states such as germ cell tumors, leukemia, lymphoma, and chondrosarcoma have also reported high QRICH1 expression.
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PPIB is the second of 18 cyclophilins to be identified in humans, after CypA. PPIB localizes to the endoplasmic reticulum (ER) and participates in many biological processes, including mitochondrial metabolism, apoptosis, redox, and inflammation, as well as in related diseases and conditions, such as ischemic reperfusion injury, AIDS, and cancer. It is also associated with viral infections. In eukaryotes, cyclophilins localize ubiquitously to many cell and tissue types.
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C1orf162 is not ubiquitously expressed in humans. According to microarray-assessed tissue expression patterns, C1orf162 is most highly expressed in bone marrow, lung, fetal liver, lymph node, spleen, and thymus in normal human tissues. Staining of normal tissues has found high levels of RNA expression in bone marrow, lymph node, spleen, and lung tissue, which coincides with microarray-assessed expression patterns. Expression of C1orf162 in normal human tissues.
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Heterogeneous nuclear ribonucleoprotein H is a protein that in humans is encoded by the HNRNPH1 gene. This gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport.
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This gene encodes a member of the non-histone chromosomal high-mobility group protein family. The proteins of this family are chromatin-associated and ubiquitously distributed in the nucleus of higher eukaryotic cells. In vitro studies have demonstrated that this protein is able to efficiently bend DNA and form DNA circles. These studies suggest a role in facilitating cooperative interactions between cis-acting proteins by promoting DNA flexibility.
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Ras-related protein Rab-18 is a protein that in humans is encoded by the RAB18 gene. Rab18 is a ubiquitously expressed protein with particularly high expression in the brain. Rab18 was first characterised as an endosomal protein in epithelial cells of mouse kidney and intestines. Subsequent studies revealed that Rab18 has a wide intracellular distribution; localising to the Golgi complex, endoplasmic reticulum, lipid droplets, and cytosol of various cell types.
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Heterogeneous nuclear ribonucleoprotein H3 is a protein that in humans is encoded by the HNRNPH3 gene. This gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport.
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YY1 is a ubiquitously distributed transcription factor belonging to the GLI-Kruppel class of zinc finger proteins. The protein is involved in repressing and activating a diverse number of promoters. Hence, the YY in the name stands for "yin-yang." YY1 may direct histone deacetylases and histone acetyltransferases to a promoter in order to activate or repress the promoter, thus implicating histone modification in the function of YY1.
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Additional examples of superradiance in astrophysical environments include the study of radiation flares in maser-hosting regions and fast radio bursts . Evidence of superradiance in these settings suggests the existence of intense emissions from entangled quantum mechanical states, involving a very large number of molecules, ubiquitously present across the universe and spanning large distances (e.g. from a few kilometres in the interstellar medium to possibly over several billion kilometres ).
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The GEO profile of LOC644249 on adipose tissue. This GEO profile of LOC644249 was included in a gene expression profile which was conducted in a study that analyzed adipose tissues of subjects at risk of metabolic syndrome. This GEO profile may suggest that LOC644249 is ubiquitously expressed in adipose tissue but no direct correlation of the effects of the expression levels of LOC644249 with adipose tissue can be made.
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SDHAF1 is located on the q arm of chromosome 19 in position 13.12 and has 1 exon. The SDHAF1 gene produces a 12.8 kDa protein composed of 115 amino acids. SDHAF1 is ubiquitously expressed and belongs to the complex I LYR family and SDHAF1 subfamily. As such, SDHAF1 is one of at least eight proteins that has a LYR tripeptide motif, thought to be important for Fe-S metabolism.
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Transglutaminases are human enzymes ubiquitously present in the human body and in the brain in particular. The main function of transglutaminases is bind proteins and peptides intra- and intermolecularly, by a type of covalent bonds termed isopeptide bonds, in a reaction termed transamidation or crosslinking. Transglutaminase binding of these proteins and peptides make them clump together. The resulting structures are turned extremely resistant to chemical and mechanical disruption.
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The Mean RPKM Values of 27 Different Human Tissues From RNA-Sequencing of LOC101928193. The protein is most highly expressed in the thyroid, ovaries, skin, and testes.LOC101928193 is not expressed ubiquitously, but is instead tissue specific in low levels of mRNA abundance compared to other human proteins. LOC101928193 has the highest level of expression in the thyroid and has high levels of expression in the ovaries, skin, and testes.
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In case of tongue fallen backwards, blocking the airway, it is necessary to hyperextend the head and pull up the chin, so that the tongue lifts and clears the airway. Certain skills are considered essential to the provision of first aid and are taught ubiquitously. Particularly the "ABC"s of first aid, which focus on critical life-saving intervention, must be rendered before treatment of less serious injuries. ABC stands for Airway, Breathing, and Circulation.
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Four alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. p38α MAPK is ubiquitously expressed in many cell types, in contrast, p38β MAPK is highly expressed in brain and lung, p38γ MAPK mostly in skeletal muscle and nerve system, and p38δ MAPK in uterus and pancreas. Like all MAP kinases, p38α MAPK has 11 conserved domains (Domains I to XI) and a Thr-Gly-Tyr (TGY) dual phosphorylation motif.
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Ubiquitin conjugating enzyme E2 Z (UBE2Z), also known as UBA6-specific E2 enzyme 1 (USE1), is an enzyme that in humans is encoded by the UBE2Z gene on chromosome 17. It is ubiquitously expressed in many tissues and cell types. UBE2Z is an E2 ubiquitin conjugating enzyme and participates in the second step of protein ubiquitination during proteolysis. A genome-wide association study (GWAS) revealed the UBE2Z gene to be associated with chronic kidney disease.
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Transmembrane protein 63A is a protein that in humans is encoded by the TMEM63A gene. The mature human protein is approximately 92.1 kilodaltons (kDa), with a relatively high conservation of mass in orthologs. The protein contains eleven transmembrane domains and is inserted into the membrane of the lysosome. BioGPS analysis for TMEM63A in humans shows that the gene is ubiquitously expressed, with the highest levels of expression found in T-cells and dendritic cells.
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Deluxe Paint began as an in- house art development tool called Prism. As author Dan Silva added features to Prism, it was developed as a showcase product to coincide with the Amiga's debut in 1985. Upon release, it was quickly embraced by the Amiga community and became the de facto graphics (and later animation) editor for the platform. It was used almost ubiquitously in the making of Amiga games, animation and demoscene productions.
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Diptericin is a 9 kDa antimicrobial peptide (AMP) of flies first isolated from the blowfly Phormia terranova. It is primarily active against Gram-negative bacteria, disrupting bacterial membrane integrity. The structure of this protein includes a proline-rich domain with similarities to the AMPs drosocin, pyrrhocoricin, and abaecin, and a glycine-rich domain with similarity to attacin. Diptericin is an iconic readout of immune system activity in flies, used ubiquitously in studies of Drosophila immunity.
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Pre-mRNA-splicing regulator WTAP is a protein that in humans is encoded by the WTAP gene. The Wilms tumor suppressor gene WT1 appears to play a role in both transcriptional and posttranscriptional regulation of certain cellular genes. This gene encodes a WT1-associating protein, which is a ubiquitously expressed nuclear protein. Like WT1 protein, this protein is localized throughout the nucleoplasm as well as in speckles and partially colocalizes with splicing factors.
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Though uncoupling the membrane potential typically leads to apoptosis, ANT2 was found to be antiapoptotic. As a result, it is postulated to mediate the TFIIH-dependent response to DNA damage as a component of the MMS19-XPD. Alternatively, suppressing the expression of this gene has been shown to induce apoptosis and inhibit tumor growth. Though ANT2 is highly conserved and ubiquitously expressed, its expression levels and, accordingly, biological function, may vary depending on tissue type.
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This gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm.
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Ubiquitously, the song garnered acclaim, many reviewers saying the song was one of the best songs Del Rey has ever written and praising Del Rey's voice. Appearing on three of Del Rey's albums to date, the song is one of few that was authored solely by her. The original version of the song was released through 5 Point Records and produced by David Kahne, later being remastered by Emile Haynie and Dan Heath.
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This gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm.
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Although PTTG1IP is ubiquitously expressed in normal human tissues, its exact function remains elusive. It has been shown to directly interact with the human securin and proto-oncogene, PTTG1, thus facilitating its nuclear translocation and the subsequent transcriptional activation of basic fibroblast growth factor (bFGF) by PTTG1. Further evidence suggests that PTTG1IP may have a direct role in cancer. Initially, PTTG1IP expression was found to be higher in pituitary tumours compared with normal pituitary tissue.
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Using phylogenetic analyses of ribosomal DNA sequences, Geomyces species have been implicated in the biodeterioration of antique and optical glass. Feeding off organic residues ubiquitously present on historical glass, such as dust or dead fungal and bacterial material, fungal colonization by Geomyces may ultimately lead to etching, pit corrosion, or the formation of cracks or patinas due to secretion of acidic metabolic byproducts, or penetration of fungal mycelia into the paint layer.
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5), e.g. the Rho family members Rac and Cdc42 by the process of glycosylation of threonine 35 in Cdc42 and Rac, and threonine 37 in Rho. These Rho GTPases are found ubiquitously in the cytosol of eukaryotic cells that are responsible for the organization of the actin cytoskeleton because the toxins in the cytosol cause condensation of actin filaments as a consequence of cell rounding and membrane blebbing (Fig. 3), which ultimately leads to apoptosis.
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However, ethnic Chinese are constituting an increasingly dominant proportion. A 1986 estimate by the Flushing Chinese Business Association approximated 60,000 Chinese in Flushing alone. The popular styles of Chinese cuisine are ubiquitously accessible in Flushing Chinatown, including Taiwanese, Shanghainese, Hunanese, Szechuan, Cantonese, Fujianese, Xinjiang, Zhejiang, and Korean Chinese cuisine. Even the relatively obscure Dongbei style of cuisine indigenous to Northeast China is now available in Flushing Chinatown, as well as Mongolian cuisine.
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Although the precise neural mechanisms underlying disorders of impulse control are not fully known, the prefrontal cortex (PFC) is the brain region most ubiquitously implicated in impulsivity. Damage to the prefrontal cortex has been associated with difficulties preparing to act, switching between response alternatives, and inhibiting inappropriate responses. Recent research has uncovered additional regions of interest, as well as highlighted particular subregions of the PFC, that can be tied to performance in specific behavioral tasks.
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The episode deviates significantly from the original story line. The passage containing Tintin's drunkenness has been ignored entirely, keeping the character consistent with how it is seen in the rest of series - upright, conscientious and of commendable moral standards. Besides, the political narratives, almost ubiquitously present in the latter part of the original album, have also been largely overlooked. Tintin's conflict with the military was also replaced with one with Alonso Pérez and Ramón Bada.
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This gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA-binding proteins, and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm.
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HNF1 homeobox A (hepatocyte nuclear factor 1 homeobox A), also known as HNF1A, is a human gene on chromosome 12. It is ubiquitously expressed in many tissues and cell types. The protein encoded by this gene is a transcription factor that is highly expressed in the liver and is involved in the regulation of the expression of several liver-specific genes. Mutations in the HNF1A gene have been known to cause diabetes.
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This gene belongs to the A/B subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm.
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Calpain, a heterodimer consisting of a large and a small subunit, is a major intracellular protease, although its function has not been well established. This gene encodes a muscle-specific member of the calpain large subunit family that specifically binds to titin. Mutations in this gene are associated with limb-girdle muscular dystrophies type 2A. Alternate promoters and alternative splicing result in multiple transcript variants encoding different isoforms and some variants are ubiquitously expressed.
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This gene belongs to the A/B subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm.
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This gene encodes a ubiquitously expressed nuclear protein that belongs to a highly conserved subfamily of WD-repeat proteins. It is present in protein complexes involved in histone acetylation and chromatin assembly. It is part of the Mi-2/NuRD complex that has been implicated in chromatin remodeling and transcriptional repression associated with histone deacetylation. This encoded protein is also part of corepressor complexes, which is an integral component of transcriptional silencing.
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This gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA binding proteins that form complexes with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm.
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Cathepsin D is a protein that in humans is encoded by the CTSD gene. This gene encodes a lysosomal aspartyl protease composed of a protein dimer of disulfide-linked heavy and light chains, both produced from a single protein precursor. Cathepsin D is an aspartic endo-protease that is ubiquitously distributed in lysosomes. The main function of cathepsin D is to degrade proteins and activate precursors of bioactive proteins in pre-lysosomal compartments.
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Expression extends anteriorly and ends sharply at the ZLI, with high expression along the line where Shh is expressed. Before the ZLI is formed, OTX2] is expressed ubiquitously throughout the forebrain, and begins to recede to the position of the putative ZLI. Experiments where OTX2] expression was repressed showed no dorsal movement of Shh expression and no ZLI formation. Irx1, which is analogous to IRX3 in birds and mammals, is expressed posterior to the ZLI.
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Desmocollin-2 contains five N-terminal extracellular domains, a transmembrane-spanning domain, and a C-terminal cytoplasmic tail. Desmocollin-2 binds to desmoglein family members through a calcium-dependent interaction with its extracellular domains, and to plakoglobin through its cytoplasmic tail. Desmocollin-2 is ubiquitously expressed in desmosomal tissues, such as skin epithelia, and is the only desmocollin isoform expressed in human cardiac muscle, where it localizes to desmosomes within intercalated discs.
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This gene is expressed ubiquitously with higher levels in fetal than in adult tissues. It encodes a protein sharing 93% sequence identity with the mouse protein. Wolf-Hirschhorn syndrome (WHS) is a malformation syndrome associated with a hemizygous deletion of the distal short arm of chromosome 4. This gene is mapped to the 165 kb WHS critical region, and may play a role in the phenotype of the WHS or Pitt-Rogers-Danks syndrome.
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Probable histone-lysine N-methyltransferase NSD2 is an enzyme that in humans is encoded by the WHSC1 gene. This gene encodes a protein that contains four domains present in other developmental proteins: a PWWP domain, an HMG box, a SET domain, and a PHD-type zinc finger. It is expressed ubiquitously in early development. Wolf-Hirschhorn syndrome (WHS) is a malformation syndrome associated with a hemizygous deletion of the distal short arm of chromosome 4.
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Generally, the temperature, duration, and ramping rate can be independently controlled for specific heating requirements. Since high- temperature heating is ubiquitously used for reactions and materials synthesis, innovative TSS processes have been discovered and demonstrated, including microwave, laser, rapid radiative heating, and discharge flash heating, enabling synthesis of diverse emerging materials, such as single atom and alloyed catalysts, high entropy alloy nanoparticles, nanoscale composites, battery cathodes and anodes, and high-quality graphene, etc.
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These include all the true grains (rice, wheat, maize, etc.), the pasture grasses, sugar cane, and the bamboos. True grasses have evolved to become highly specialised for wind pollination. Grasses produce much smaller flowers, which are gathered in highly visible plumes (inflorescences). Other economically important monocot families are the palm family (Arecaceae), banana family (Musaceae), ginger family (Zingiberaceae) and the onion family Alliaceae, which includes such ubiquitously used vegetables as onions and garlic.
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This gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are produced by RNA polymerase II and are components of the heterogeneous nuclear RNA (hnRNA) complexes. They are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm.
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Protein mago nashi homolog is a protein that in humans is encoded by the MAGOH gene. Drosophila that have mutations in their mago nashi (grandchildless) gene produce progeny with defects in germplasm assembly and germline development. This gene encodes the mammalian mago nashi homolog. In mammals, mRNA expression is not limited to the germ plasm, but is expressed ubiquitously in adult tissues and can be induced by serum stimulation of quiescent fibroblasts.
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Neurofibromin is ubiquitously expressed, but expression levels vary depending on the tissue type and developmental stage of the organism. Expression is at its highest level in adult neurons, Schwann cells, astrocytes, leukocytes, and oligodendrocytes. The catalytic RasGAP activity of neurofibromin is located in a central portion of the protein, that is called the GAP-related domain (GRD). The GRD is closely homologous to RasGAP and represents about 10% (229 amino acids) of the neurofibromin sequence.
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Many of the stories and motifs found in the Jātaka such as the Rabbit in the Moon of the Śaśajātaka (Jataka Tales: no.316),Source: sacred-texts.com (accessed: Saturday January 23, 2010) are found in numerous other languages and media. For example, The Monkey and the Crocodile, The Turtle Who Couldn't Stop Talking and The Crab and the Crane that are listed below also famously featured in the Hindu Panchatantra, the Sanskrit niti-shastra that ubiquitously influenced world literature.
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Despite having been approved for use in local television, Cantonese still faces restrictions and challenges in other aspects of social activities, which contributes to the decline of the language, particularly in the younger generations. In elementary and secondary schools, the medium of instruction is mandated by law to be Mandarin. Use of Mandarin is also ubiquitously promoted in schools. In contrast, few, if any, local schools offer classes on Cantonese, although this is not explicitly forbidden by law.
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While SCS is ubiquitously expressed, SUCLA2 is predominantly expressed in catabolic tissues reliant on ATP as their main energy source, including heart, brain, and skeletal muscle. Within the brain, SUCLA2 is found exclusively in neurons; meanwhile, both SUCLA2 and SUCLG2 are absent in astrocytes, microglia, and oligodendrocytes. In order to acquire succinate to continue the TCA cycle, these cells may instead synthesize succinate through GABA metabolism of α-ketoglutarate or ketone body metabolism of succinyl-CoA.
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Ceramide synthase 2, also known as LAG1 longevity assurance homolog 2 or Tumor metastasis-suppressor gene 1 protein is an enzyme that in humans is encoded by the CERS2 gene. Ceramide synthase 2 is a ceramide synthase that catalyses the synthesis of very long acyl chain ceramides, including C20 and C26 ceramides. It is the most ubiquitously expressed of all CerS and has the broadest distribution in the human body. CerS2 was first identified in 2001.
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As a member of the FASTKD family, TBRG4 localizes to the mitochondria to modulate their energy balance, especially under conditions of stress. Though ubiquitously expressed in all tissues, TBRG4 appears more abundantly in skeletal muscle, heart muscle, and other tissues enriched in mitochondria. TBRG4 also localizes to the bone marrow (BM), where it functions in hematopoiesis by inducing IL-6 and VEGF secretion, which then stimulate cell proliferation and angiogenesis. However, it inhibits immunoglobulin secretions by normal B cells.
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Myeloid/lymphoid or mixed-lineage leukemia 4, also known as MLL4, is a human gene. This gene encodes a protein which contains multiple domains including a CXXC zinc finger, three PHD zinc fingers, two FY-rich domains, and a SET (suppressor of variegation, enhancer of zeste, and trithorax) domain. The SET domain is a conserved C-terminal domain that characterizes proteins of the MLL (mixed-lineage leukemia) family. This gene is ubiquitously expressed in adult tissues.
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The mRNA expressed and levels of expression differ based on the location and tissue type in the body, but overall has been found to be expressed ubiquitously. The highest expression has been found in differentiating, rather than proliferating, tissue zones. Transcript was identified with the highest confidence in the erythroleukemia, placental cells and overall in the brain, and at a medium confidence level in the perirhinal cortex, medial temporal lobe, colon, as well in the salivary and adrenal glands.
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As a cyclophilin, PPI binds cyclosporin A (CsA) and can be found within in the cell or secreted by the cell. In eukaryotes, cyclophilins localize ubiquitously to many cell and tissue types, though PPIC especially is highly expressed in kidney. In addition to PPIase and protein chaperone activities, cyclophilins function in mitochondrial metabolism, apoptosis, immunological response, inflammation, and cell growth and proliferation. Along with PPIB, PPIC localizes to the endoplasmic reticulum (ER), where it maintains redox homeostasis.
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Breeding requires pollinating a female cannabis plant with male pollen. Although this occurs spontaneously and ubiquitously in nature, the intentional creation of new varieties typically involves selective breeding in a controlled environment. A flowering cannabis plant When cannabis is cultivated for its psychoactive or medicinal properties, male plants will often be separated from females. This prevents fertilization of the female plants, either to facilitate sin semilla flowering or to provide more control over which male is chosen.
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Waste management is provided through the region, and is co-ordinated with programs offered in other towns in York Region. Weekly green bin compost collection began in September 2007 to complement the weekly blue box collection of recyclable material; collection of all other waste was reduced to once every two weeks. Water and wastewater management is operated by the township, though these services are not available ubiquitously; some areas rely on well water and septic tanks.
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The name now refers only to a family of proteins with similar structure and function, not to the mechanism of their activation. Later, TRP channels were found in vertebrates where they are ubiquitously expressed in many cell types and tissues. There are about 28 TRP channels that share some structural similarity to each other. These are grouped into two broad groups: group 1 includes TRPC ( "C" for canonical), TRPV ("V" for vanilloid), TRPM ("M" for melastatin), TRPN and TRPA.
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In adult mice, miR-138 is only expressed in brain tissue. Its expression is not uniform throughout the brain but restricted to distinct neuronal populations. On the contrary, its precursor, pre-miR-138-2, is ubiquitously expressed throughout all tissues, which suggests that the expression of miRNAs can be regulated at the post-transcription level. In the zebrafish, miR-138 is expressed in specific domains in the heart and is required to establish appropriate chamber-specific gene expression patterns.
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An intervening loop region, which is thought to play a role in protein-protein interactions, separates this from the C-terminal region, which exhibits the greatest sequence variation and may be involved in membrane binding. This motif marks PITP as part of the larger SRPBCC (START/RHOalphaC/PITP/Bet v1/CoxG/CalC) domain superfamily. PITP alpha (UniProt ) has a 16-fold greater affinity for PI than PC. Together with PITP beta (UniProt ), it is expressed ubiquitously in all tissues.
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This game also saw the first appearance of the much longer 'baggy' style of shorts, sported as part of Tottenham Hotspur's new Umbro kit, which Terry Venables helped design. Though attracting some ridicule at first, the style swiftly became popular, being adopted during the early 1990s throughout English and world football by every team at every level (with no team anywhere having reverted to the 'short shorts' worn ubiquitously for some decades up to this match).
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Eukaryotic genomes are ubiquitously associated into chromatin; however, cells must spatially and temporally regulate specific loci independently of bulk chromatin. In order to achieve the high level of control required to co-ordinate nuclear processes such as DNA replication, repair, and transcription, cells have developed a variety of means to locally and specifically modulate chromatin structure and function. This can involve covalent modification of histones, the incorporation of histone variants, and non-covalent remodelling by ATP-dependent remodeling enzymes.
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Protein phosphatase 2 (PP2), also known as PP2A, is an enzyme that in humans is encoded by the PPP2CA gene. The PP2A heterotrimeric protein phosphatase is ubiquitously expressed, accounting for a large fraction of phosphatase activity in eukaryotic cells. Its serine/threonine phosphatase activity has a broad substrate specificity and diverse cellular functions. Among the targets of PP2A are proteins of oncogenic signaling cascades, such as Raf, MEK, and AKT, where PP2A may act as a tumor suppressor.
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Translationally controlled tumor protein was first discovered in 1989 as a cDNA sequence obtained from a human mammary carcinoma cDNA library with proves derived from the translationally controlled, growth-related mouse tumor protein TCTP. TCTP was originally described as a growth related protein of tumor cells. Its mRNA accumulates in translationally repressed postpolysomal mRNP-complexes. Research in 1997 shown that TCTP is not a tumor- or tissue- specific protein, but is expressed ubiquitously from plants to mammals.
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The production of electronic encyclopedias began as conversions of printed work, but soon added multimedia elements, requiring new methods of content gathering and presentation. Early applications of hypertext similarly had a great benefit to readers but did not require significant changes in writing. The launching of Wikipedia in the 2000s and its subsequent rise in popularity and influence, however, radically altered popular conception of the ways in which an encyclopedia is produced (collaboratively, openly) and consumed (ubiquitously).
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Baylisascaris procyonis, common name raccoon roundworm, is a roundworm nematode, found ubiquitously in raccoons, the definitive hosts. It is named after H. A. Baylis, who studied them in the 1920s–30s, and Greek askaris (intestinal worm). Baylisascaris larvae in paratenic hosts can migrate, causing visceral larva migrans (VLM). Baylisascariasis as the zoonotic infection of humans is rare, though extremely dangerous due to the ability of the parasite's larvae to migrate into brain tissue and cause damage.
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The eEF1A1 protein is an isoform of the eEF-1 complex alpha subunit, an elongation factor protein, a GTPase, and an actin bundling protein. As an elongation factor, it is known to mediate the recruitment of aminoacyl-tRNA to the A-site of the 80S ribosome during protein synthesis. As a result, this protein is ubiquitously expressed. In addition to its role in translation, eEF1A has been shown to play a central role in the nuclear export of proteins.
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440x440px UCK2 is one of two human uridine-cytidine kinases. The other UCK protein is uridine-cytidine kinase 1, which shares about 70% sequence identity with UCK2. While UCK1 is expressed ubiquitously in a variety of healthy tissues including the liver, skeletal muscle, and heart, UCK2 has only been detected in placental tissue. UCK2, however, is of particular scientific interest due to its overexpression in tumor cell lines, which makes it a target in anti-cancer treatments.
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Rab GDP dissociation inhibitor beta is a protein that in humans is encoded by the GDI2 gene. GDP dissociation inhibitors are proteins that regulate the GDP- GTP exchange reaction of members of the rab family, small GTP-binding proteins of the ras superfamily, that are involved in vesicular trafficking of molecules between cellular organelles. GDIs slow the rate of dissociation of GDP from rab proteins and release GDP from membrane-bound rabs. GDI2 is ubiquitously expressed.
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As a cyclophilin, PPID binds cyclosporin A (CsA) and can be found within in the cell or secreted by the cell. In eukaryotes, cyclophilins localize ubiquitously to many cell and tissue types. In addition to PPIase and protein chaperone activities, cyclophilins also function in mitochondrial metabolism, apoptosis, immunological response, inflammation, and cell growth and proliferation. PPID in particular helps chaperone the assembly of heat shock protein Hsp90, as well as the nuclear localization of glucocorticoid, estrogen and progesterone receptors.
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Lysophosphatidic acid phosphatase has several roles. Although lysophosphatidic acid phosphatase is found ubiquitously throughout the body with higher levels in the kidney, heart, small intestine, muscles and the liver, evidence suggests that this enzyme is regulates lipid metabolism in the mitochondria. Another function is to control the concentration of LPAs that serve as messengers for G protein- coupled receptors in the cell. These LPAs are responsible for the signaling of cell growth, proliferation, muscle contractions, and wound healing, among many other roles.
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As a cyclophilin, PPI binds cyclosporin A (CsA) and can be found within in the cell or secreted by the cell. In eukaryotes, cyclophilins localize ubiquitously to many cell and tissue types, though studies on PPIF focus primarily on heart, liver, and brain tissue. In addition to PPIase and protein chaperone activities, cyclophilins also function in mitochondrial metabolism, apoptosis, immunological response, inflammation, and cell growth and proliferation. PPIF is especially involved in mitochondrial apoptosis as a major component of the MPTP.
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Charles Archibald Walker Rose CIE FRGS (1879-1961), ubiquitously known as Archie Rose, was a British diplomat, explorer and businessman in China during the early twentieth century.Obituary in The Times, Mr. Archibald Rose, 9 March 1961, p.19 Rose's obituary in The Times stated that he was 'a lovable and saint-like man. His dandiacal appearance and his taste for drollery were unsure guides to his true character, in which the dominant strain was a sort of earnest but unobtrusive chivalry'.
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As can be learned from the article Linux range of use, Linux kernel-based operating systems are ubiquitously found on diverse hardware platforms. This article, Linux for mobile devices, is about the use of Linux kernel-based operating systems on all sorts of mobile devices, whose primary or only Human interface device (HID) is a touchscreen. This mainly comprises smartphones and tablet computers, but also some mobile phones, personal digital assistants (PDAs) portable media players that come with a touchscreen separately.
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MIF4GD, or MIF4G domain-containing protein, is a protein which in humans is encoded by the MIF4GD gene. It is also known as SLIP1, SLBP (Stem-Loop Binding Protein)-interacting protein 1, AD023, and MIFD. MIF4GD is expressed ubiquitously in humans, and has been found to be involved in activating proteins for histone mRNA translation, alternative splicing and translation of mRNAs, and is a factor in the regulation of cell proliferation.MIF4GD is located on human chromosome 17q25.1 (second white band from bottom).
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Dipeptidyl peptidase 8 is an enzyme that in humans is encoded by the DPP8 gene. This gene encodes a member of the peptidase S9B family, a small family of dipeptidyl peptidases that are able to cleave peptide substrates at a prolyl bond. The encoded protein shares similarity with Dipeptidyl peptidase-4 in that it is ubiquitously expressed, and hydrolyzes the same substrates. These similarities suggest that, like dipeptidyl peptidase IV, this protein may play a role in T-cell activation and immune function.
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Ras-related protein M-Ras, also known as muscle RAS oncogene homolog and R-Ras3, is a protein that in humans is encoded by the MRAS gene on chromosome 3. It is ubiquitously expressed in many tissues and cell types. This protein functions as a signal transducer for a wide variety of signaling pathways, including those promoting neural and bone formation as well as tumor growth. The MRAS gene also contains one of 27 SNPs associated with increased risk of coronary artery disease.
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The WDR12 gene is ubiquitously expressed during embryogenesis, and high levels are found in the thymus and testis of adult mice. It is a crucial factor in the mammalian ribosome biogenesis pathway that forms a stable complex named PeboW with Pes1 and Bop1. WDR12 is required for processing of the 32S precursor rRNA without affecting the synthesis of the 45S/47S primary transcript and it functions in the maturation of the 60S ribosomal subunit. Depletion of WDR12 severely inhibits cell proliferation.
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Because L. rigidum has been grown as a forage crop in southern Australia since the nineteenth century and seeds readily, it grows ubiquitously in the region with large, genetically diverse populations. Now that arable crops are increasingly been grown, it has become an important weed of these crops. Attempts to control it with herbicide have met with an unexpectedly high level of herbicide resistance. Over 90% of plants in some populations are tolerant to some of the widely used herbicides.
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CNI Program Plan, CNI. ;Transforming organization, professions, and individuals The pervasiveness of ubiquitously accessible digital information is transforming institutions, professions, and the practices of learning and scholarship. CNI focuses on the unprecedented need for collaboration among libraries, information technology and instructional technology groups, faculty, museums, archives, university presses, and other units in order to achieve success in this environment. In addition, we promote new alliances and partnerships with publishers, information technology and network service providers, scholarly societies, government, and other sectors.
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This gene encodes a ubiquitously expressed coiled-coil domain-containing protein that interacts with the dishevelled protein and is a negative regulator of the Wnt signalling pathway. The protein encoded by this gene has a PDZ domain binding motif in its C-terminus, with which it interacts with the dishevelled protein. Dishevelled is a scaffold protein involved in the regulation of the Wnt signaling pathway. The Wnt signaling pathway plays an important role in embryonic development, tissue, and cancer progression.
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The B2 receptor is a G protein-coupled receptor, coupled to Gq and Gi. Gq stimulates phospholipase C to increase intracellular free calcium and Gi inhibits adenylate cyclase. Furthermore, the receptor stimulates the mitogen-activated protein kinase pathways. It is ubiquitously and constitutively expressed in healthy tissues. The B2 receptor forms a complex with angiotensin converting enzyme (ACE), and this is thought to play a role in cross-talk between the renin-angiotensin system (RAS) and the kinin-kallikrein system (KKS).
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Charcot-marie-tooth foot Also known as Charcot–Marie–Tooth neuropathy, hereditary motor and sensory neuropathy (HMSN) and peroneal muscular atrophy (PMA). This is a genetically and clinically heterogeneous group of inherited disorders, characterized by prominent sensory loss, often complicated by severe ulcero-mutilations of toes or feet, and variable motor involvement. Missense mutations in RAB7A, the gene encoding the small GTPase Rab7, cause CMT2B and increase Rab7 activity. Rab7 is ubiquitously expressed and is involved in degradation through the lysosomal pathway.
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The B2 receptor is a G protein- coupled receptor, probably coupled to Gq and Gi. Gq stimulates phospholipase C to increase intracellular free calcium and Gi inhibits adenylate cyclase. Furthermore, the receptor stimulates the mitogen-activated protein kinase pathways. It is ubiquitously and constitutively expressed in healthy tissues. The B2 receptor forms a complex with angiotensin converting enzyme (ACE), and this is thought to play a role in cross-talk between the renin-angiotensin system (RAS) and the kinin-kallikrein system (KKS).
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However, the corresponding residue in glucose 6-phosphatase-α (Lys76) resides within the ER membrane and its function, if any, is currently undetermined. With the exception of Lys76, these residues are all located on the luminal side of the ER membrane. Glucose 6-phosphatase-β is a ubiquitously expressed, 346-amino acid membrane protein that shares 36% sequence identity with glucose 6-phosphatase-α. Within the glucose 6-phosphatase-β enzyme, sequence alignments predict that its active site contains His167, His114, and Arg79.
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The existence of a receptor for transferrin iron uptake had been recognized over half a century back. Earlier two transferrin receptors in humans, transferrin receptor 1 and transferrin receptor 2 had been characterized and until recently cellular iron uptake was believed to occur chiefly via these two well documented transferrin receptors. Both these receptors are transmembrane glycoproteins. TfR1 is a high affinity ubiquitously expressed receptor while expression of TfR2 is restricted to certain cell types and is unaffected by intracellular iron concentrations.
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XBP1 is part of the endoplasmic reticulum (ER) stress response, the unfolded protein response (UPR). Conditions that exceed capacity of the ER provoke ER stress and trigger the unfolded protein response (UPR). As a result, GRP78 is released from IRE1 to support protein folding. IRE1 oligomerises and activates its ribonuclease domain through auto (self) phosphorylation. Activated IRE1 catalyses the excision of a 26 nucleotide unconventional intron from ubiquitously expressed XBP1u mRNA, in a manner mechanistically similar to pre-tRNA splicing.
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The PCSK9 gene also contains one of 27 loci associated with increased risk of coronary artery disease. PCSK9 is ubiquitously expressed in many tissues and cell types. PCSK9 binds to the receptor for low-density lipoprotein particles (LDL), which typically transport 3,000 to 6,000 fat molecules (including cholesterol) per particle, within extracellular fluid. The LDL receptor (LDLR), on liver and other cell membranes, binds and initiates ingestion of LDL-particles from extracellular fluid into cells, thus reducing LDL particle concentrations.
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Analysis of IQGAP1 expression in human tissues has indicated that the scaffold is more or less ubiquitously expressed. It is usually found in the nucleus, plasma membrane, and cytoplasm. In other words it is found throughout the cell as well as throughout tissue types. Expression analysis has also indicated that IQGAP1 is overexpressed in many cancers, and in more aggressive colorectal and ovarian cancers, IQGAP1 is localized at the invasive front of the neoplasm, indicating a role in mobilization of the cells.
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In humans, transcription of ALA synthase is tightly controlled by the presence of Fe2+-binding elements, to prevent accumulation of porphyrin intermediates in the absence of iron. There are two forms of ALA synthase in the body. One form is expressed in red blood cell precursor cells (ALAS2), whereas the other (ALAS1) is ubiquitously expressed throughout the body. The red blood cell form is coded by a gene on chromosome x, whereas the other form is coded by a gene on chromosome 3.
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This gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing(reference: Koenig J. nature structural and Molecular Biology 2010: iCLIP) and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm.
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The popular styles of Chinese cuisine are ubiquitously accessible in Flushing, including Hakka, Taiwanese, Shanghainese, Hunanese, Szechuan, Cantonese, Fujianese, Xinjiang, Zhejiang, and Korean Chinese cuisine. Even the relatively obscure Dongbei style of cuisine indigenous to Northeast China is now available in Flushing, as well as Mongolian cuisine and Uyghur cuisine. These diverse Chinese immigrant populations have brought with them their own regional food cuisines which have led to Flushing being considered the "food mecca" for Chinese regional cuisine outside of Asia.
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NFE2L1 was first cloned in yeast using a genetic screening method. NFE2L1 is ubiquitously expressed, and high levels of transcript are detected in the heart, kidney, skeletal muscle, fat, and brain. Four separate regions — an asparagine/serine/threonine, acidic domains near the N-terminus, and a serine-rich domain located near the CNC motif — are required for full transactivation function of NFE2L1. NFE2L1 is a key regulator of cellular functions including oxidative stress response, differentiation, inflammatory response, metabolism, cholesterol handling and maintaining proteostasis.
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A differentiable manifold is a Hausdorff and second countable topological space , together with a maximal differentiable atlas on . Much of the basic theory can be developed without the need for the Hausdorff and second countability conditions, although they are vital for much of the advanced theory. They are essentially equivalent to the general existence of bump functions and partitions of unity, both of which are used ubiquitously. The notion of a manifold is identical to that of a topological manifold.
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In Indonesia, Tolak Angin is ubiquitously used and is one of the most popular consumer brands, with the product being sold in millions of small vendors. The product is well-recognized by its yellow sachet packaging, which has been copied by similar products of competitors. The brand's slogan is "Orang pintar minum Tolak Angin" ("Smart people takes Tolak Angin"). Outside of Indonesia, Tolak Angin is also sold in, for example, Philippines, Malaysia, Nigeria, Hong Kong, Australia, the Netherlands, and the United States.
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In particular, HK2 is ubiquitously expressed in tissues, though it is majorly found in muscle and adipose tissue. In cardiac and skeletal muscle, HK2 can be found bound to both the mitochondrial and sarcoplasmic membrane. HK2 gene expression is regulated by a phosphatidylinositol 3-kinaselp70 S6 protein kinase-dependent pathway and can be induced by factors such as insulin, hypoxia, cold temperatures, and exercise. Its inducible expression indicates its adaptive role in metabolic responses to changes in the cellular environment.
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The security of Australia's immediate neighbourhood which it shares with Indonesia, New Zealand, Papua New Guinea, East Timor and the island countries of the South Pacific has ubiquitously been listed as the second most important defence priority behind the ability to defend Australia from a direct military attack (Australian Government Department of Defence 2000 & 2009). The White Papers emphasise that unstable neighbours could lead to a strategic environment that might be inimical to Australia's interests (Australian Government Department of Defence 2000 & 2009).
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Various experiments showing expression of CDV3 demonstrated different patterns of tissue expression; however, it is concluded that the gene is expressed ubiquitously throughout all tissue types with more expression within tissues involved in the immune system and skeletal muscle tissue. HPA RNA-seq Normal Tissue Expression from NCBI Gene entry on CDV3. The expression of CDV3 generally decreases throughout fetal development, but expression levels remain high. Tissue-specific circular RNA induction during human fetal development from NCBI Gene entry on CDV3.
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The protein encoded by this gene shares considerable sequence similarity to, and is structurally related to DNase II. The latter is a well characterized endonuclease that catalyzes DNA hydrolysis in the absence of divalent cations at acidic pH. Unlike DNase II which is ubiquitously expressed, expression of this gene product is restricted to the salivary gland and lungs. The gene has been localized to chromosome 1p22.3 adjacent (and in opposite orientation) to the uricase pseudogene. Two transcript variants encoding different isoforms have been described for this gene.
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They also more frequently express "non-carcinomatous" markers typically associated with "dedifferentiated" neoplasms. Expression of thyroid transcription factor-1 (TTF-1), a commonly used marker for primary lung cancers, appears to be less frequent in rhabdoid carcinomas than in most other histotypes of pulmonary cancers. Vimentin, an intermediate filament protein usually found in sarcoma, is ubiquitously (nearly 100%) expressed diffusely throughout the cytoplasm of the rhabdoid cells, and is often intermingled with CK's in their whorled inclusions. Some studied have reported that neuroendocrine-related markers (i.e.
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TSBP1 is a protein that in humans is encoded by the TSBP1 gene. C6orf10 is an open reading frame on chromosome 6 containing a protein that is ubiquitously expressed at low levels in the adult genome and may play a role during fetal development. C6orf10 has been found to be linked to both neurodegenerative and autoimmune diseases in adults. Expression of this gene is highest in the testis but is also seen in other tissue types such as the brain, lens of the eye and the medulla.
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ZNF800 is expressed ubiquitously throughout the body at low levels. There does seem to be increased expression in the blood and thymus, but the evidence for this is somewhat contradictory. NCBI GEO Profiles across all tissues revealed the following expression levels in tissues throughout the body: highest expression of ZNF800 in bone marrow, liver, spleen and thymus. In situ hybritization data of ZNF800 in the mouse brain from Allen Brain Atlas showed ubiquitous expression of ZNF800 in the brain in low levels (Figure: "Mouse Brain ZNF800 Expression").
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As the recently identified fifth isoform of hexokinase, HKDC1 catalyzes the rate-limiting and first obligatory step of glucose metabolism, which is the ATP-dependent phosphorylation of glucose to G6P. Though its particular biological function remains unclear, HKDC1 has been suggested to play a more major role in glucose metabolism during pregnancy, as the mother would need to provide enough energy for both herself and the fetus. HKDC1 is ubiquitously expressed, with the highest levels of expression in pharynx, thymus, colon, esophagus, and eye tissue.
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Nuclear-interacting partner of ALK (NIPA), also known as zinc finger C3HC-type protein 1 (ZC3HC1), is a protein that in humans is encoded by the ZC3HC1 gene on chromosome 7. It is ubiquitously expressed in many tissues and cell types though exclusively expressed in the nuclear subcellular location. NIPA is a skp1 cullin F-box (SCF)-type ubiquitin E3 ligase (SCFNIPA) complex protein involved in regulating entry into mitosis. The ZC3HC1 gene also contains one of 27 SNPs associated with increased risk of coronary artery disease.
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Gamma-adducin is a protein that in humans is encoded by the ADD3 gene. Adducins are heteromeric proteins composed of different subunits referred to as adducin alpha, beta and gamma. The three subunits are encoded by distinct genes and belong to a family of membrane skeletal proteins involved in the assembly of spectrin-actin network in erythrocytes and at sites of cell-cell contact in epithelial tissues. While adducins alpha and gamma are ubiquitously expressed, the expression of adducin beta is restricted to brain and hematopoietic tissues.
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Transcription factor 21 (TCF21), also known as pod-1, capsulin, or epicardin, is a protein that in humans is encoded by the TCF21 gene on chromosome 6. It is ubiquitously expressed in many tissues and cell types and highly significantly expressed in lung and placenta. TCF21 is crucial for the development of a number of cell types during embryogenesis of the heart, lung, kidney, and spleen. TCF21 is also deregulated in several types of cancers, and thus known to function as a tumor suppressor.
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Given the C3 is constantly being turned over in the alternative pathway and its ability to rapidly amplify a signal, these proteins are important in regulating the temporal and spatial effects of C3b to infected tissues. An example RCA is membrane cofactor protein (MCP; CD46), which is ubiquitously expressed and plays a critical role in protecting host cells from damage by the C3b. Furthermore, host cells express p33 (globular C1q receptor) on the surface, which binds C1q, and prevents it from initiating complement activation.
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Baylisascaris shroederi, common name giant panda roundworm, is a roundworm (nematode), found ubiquitously in giant pandas of central China, the definitive hosts. Baylisascaris larvae in paratenic hosts can migrate, causing visceral larva migrans (VLM). It is extremely dangerous to the host due to the ability of the parasite's larvae to migrate into brain tissue and cause damage. Concern for human infection is minimal as there are very few giant pandas living today and most people do not encounter giant pandas in their everyday activities.
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TMEM217 is not ubiquitously expressed. The gene tends to have expression correlated to lymphatic system, vascular/arterial endothelial tissue, and notable expression in the bladder based on expression profiles and microarray analysis. Other tissues that have been shown to express TMEM217 include: connective tissues, the liver, mammary glands, the testis, and the cervix. Co-expression analyses have found that TMEM217 was up-regulated in response to mechanical stretch in dermal fibroblast cells and in response to the resveratrol derivative, DMU-212, in vascular endothelial tissues.
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The gene is flanked by UBR4 on its right and MRTO4 on its left. This Information is graphically displayed in Figure 1. Expressed Sequence Tags and isolated cDNA clones indicate KIAA0090 is expressed ubiquitously in low to moderate levels throughout the body. This includes but is not limited to testis, tongue, lung, cerebellum, brain, mammary gland, trachea, placenta, esophageal, salivary gland, brain, hippocampus, amygdale, bone marrow, thalamus, spleen, uterus, thymus, kidney, eye, heart, gall bladder, prostate, liver, parathyroid gland, ovary, stomach, skeletal muscle, colon, pancreas, and skin.
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There are 9 members part of the Src family kinases: c-Src, Yes, Fyn, Fgr, Yrk, Lyn, Blk, Hck, and Lck. The expression of these Src family members are not the same throughout all tissues and cell types. Src, Fyn and Yes are expressed ubiquitously in all cell types while the others are generally found in hematopoietic cells. c-Src is made up of 6 functional regions: Src homology 4 domain (SH4 domain), unique region, SH3 domain, SH2 domain, catalytic domain and short regulatory tail.
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The quantity ∇2V has been termed the concentration of V and its value at any point indicates the "excess" of the value of V there over its mean value in the neighbourhood of the point. Laplace's equation, a special case of Poisson's equation, appears ubiquitously in mathematical physics. The concept of a potential occurs in fluid dynamics, electromagnetism and other areas. Rouse Ball speculated that it might be seen as "the outward sign" of one of the a priori forms in Kant's theory of perception.
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SNAPAP is a component of the SNARE complex of proteins that is required for synaptic vesicle docking and fusion. SNAPAP is also a component of the ubiquitously expressed BLOC1 multisubunit protein complex. BLOC1 is required for normal biogenesis of specialized organelles of the endosomal-lysosomal system, such as melanosomes and platelet dense granules. Snapin has been established to be a promoter of vesicle docking, as it plays a role in binding to SNAP-25, which together stabilize and favor SNARE complex assembly and vesicle docking.
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CDKN2A, also known as cyclin-dependent kinase inhibitor 2A, is a gene which in humans is located at chromosome 9, band p21.3. It is ubiquitously expressed in many tissues and cell types. The gene codes for two proteins, including the INK4 family member p16 (or p16INK4a) and p14arf. Both act as tumor suppressors by regulating the cell cycle. p16 inhibits cyclin dependent kinases 4 and 6 (CDK4 and CDK6) and thereby activates the retinoblastoma (Rb) family of proteins, which block traversal from G1 to S-phase.
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NSF is a homohexameric AAA ATPase involved in membrane fusion. NSF is ubiquitously found in the membrane of eukaryotic cells. It is a central component of the cellular machinery in the transfer of membrane vesicles from one membrane compartment to another. During this process, SNARE proteins on two joining membranes (usually a vesicle and a target membrane such as the plasma membrane) form a complex, with the α-helical domains of the SNAREs coiling around each other and forming a very stable four-helix bundle.
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S. rhabdospora has also been cultured from samples obtained from the banks of the Sakawa River, in Japan. Drechsler initially reported that temperate, wet climates seem to promote the most growth of Stylopage species, and that North American summer temperatures were not conducive to its growth. Most samples of both nematophagous and amoebophagous species have been obtained from temperate riverbanks and forest floors, replete with rotting vegetation. More common species such as S. hadra and S. araea can be found ubiquitously in temperate Northern hemisphere leaf litter.
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The gene FAM193A is most abundantly expressed, by examination of spot intensity from its EST profile Hs.652364, in the embryonic, lymph node, nerve, uterus, testis, larynx tissues and somewhat in the blood. Unigene The gene is expressed through a number of health states, for example, adrenal, chondrosarcoma and uterine tumors, it is also implicated in soft tissue/ muscle tissue tumors. Unigene A microarray from BRAINSPAN.org within the Prenatal LCM microarray data shows high abundance of FAM193A expression in humans ubiquitously throughout the brain.
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627x627px The applications of antibody-oligonucleotide conjugates have expanded beyond CITE-seq, and can be adapted for sample multiplexing as well as CRISPR screens. Cell Hashing: New York Genome Center further adapted the use of their antibody- oligonucleotide conjugates to enable sample multiplexing for scRNA-seq. This technique called, Cell Hashing, uses oligonucleotide-labelled antibodies against ubiquitously expressed cell surface proteins from a particular tissue sample. In this case, an oligonucleotide sequence contains a unique barcode which would be specific to cells from distinct samples.
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The Human Protein Atlas reports high levels of KIAA1147 transcription in several brain regions including cerebral cortex, cerebellum, and retina, as well as non-brain regions including spleen, thymus, stomach, prostate, lung, and ascending colon. Immunohistochemistry has shown LCHN to be localized to the cytoplasmic face of the Golgi apparatus in cell culture, and the brain in mouse fetal development. In the adult mouse and human brain, LCHN is expressed relatively ubiquitously. Expression of LCHN has been shown to increase in response to chronic alcoholism, immature and mature dendritic response to hypoxia, and ischemic stroke.
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In some other football codes, such as association football (soccer), Australian rules football and Gaelic football, the kicked forward pass is used so ubiquitously that it is not thought of as a distinct kind of play at all. In association football and its variants, the concept of offside is used to regulate who can be in front of the play or be nearest to the goal. Historically some earlier incarnations of football allowed unlimited forward passing, and present-day Australian rules football and Gaelic football do not have an offside rule.
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Phytoglobins (abbreviated as Phytogbs) are ubiquitously distributed in plants as they have been identified in algae and land plants, including primitive bryophytes and evolved monocots and dicots. They are classified as Phytogbs0, Phytogbs1 and Phytogbs2 (formerly known as non-symbiotic hemoglobins), symbiotic Phytogbs, leghemoglobins (abbreviated as Lbs) and Phytogbs3.Hill R., Hargrove M. S.,Arredondo-Peter R., Phytoglobin: a novel nomenclature for plant globins accepted by the globin community at the 2014 XVIII conference on Oxygen- Binding and Sensing Proteins., F1000Research, 5 (2016) 212 (doi: 210.12688/f11000research.18133.12681).
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Microarray and RNA seq data suggest that IRX1 is ubiquitously expressed at low levels in adult tissues, with the highest relative levels of expression occurring in the heart, adipose, kidney, and breast tissues. Moderate to high levels are also indicated in the lung, prostate and stomach. Promoter analysis with the El Dorado program from Genomatix predicted that IRX1 expression is regulated by factors that include E2F cell cycle regulators, NRF1, and ZF5, and brachyury. Expression data from human, mouse, and developing mouse brains are available though the Allen Brain Atlas.
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Chromosome transmission fidelity protein 8 homolog is a protein that in humans is encoded by the CHTF8 gene. This gene encodes a short protein that forms part of the Ctf18 replication factor C (RFC) complex that occurs in both yeast and mammals. The heteroheptameric RFC complex plays a role in sister chromatid cohesion and may load the replication clamp PCNA (proliferating cell nuclear antigen) onto DNA during DNA replication and repair. This gene is ubiquitously expressed and has been shown to have reduced expression in renal and prostate tumors.
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VDACs have also been observed to interact with pro- or antiapoptotic proteins, such as Bcl-2 family proteins and kinases, and so may contribute to apoptosis independently from the MPTP. VDAC2 in particular has demonstrated a protective effect in cells undergoing mitochondrial apoptosis, and may even confer protection during aging. Furthermore, VDAcs have been linked to spermatogenesis, sperm maturation, motility, and fertilization. Though all VDAC isoforms are ubiquitously expressed, VDAC2 is majorly found in the sperm outer dense fiber (ODF), where it is hypothesized to promote proper assembly and maintenance of sperm flagella.
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Nonetheless, experiments reveal a lack of pore-forming ability in the VDAC3 isoform, suggesting that it may perform different biological functions. Notably, though all VDAC isoforms are ubiquitously expressed, VDAC3 is majorly found in the sperm outer dense fiber (ODF), where it is hypothesized to promote proper assembly and maintenance of sperm flagella. Because the ODF membranes are not likely to support pore formation, VDAC3 may interact with protein partners to carry out other functions in the ODF. For instance, within cells, VDAC3 predominantly localizes to the centrosome and recruits Mps1 to regulate centriole assembly.
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However, the microbial community in sea spray is often distinct from nearby water and sandy beaches, suggesting that some species are more biased towards SSA transportation than others. Sea spray from one beach can contain thousands of operational taxonomic units (OTUs). Nearly 10,000 different OTUs have been discovered in sea spray just between San Francisco, CA and Monterey, CA, with only 11% of them found ubiquitously. This suggests that sea spray in every coastal region likely has its own unique assemblage of microbial diversity, with thousands of new OTUs yet to be discovered.
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Surfeit locus protein 6 is a protein that in humans is encoded by the SURF6 gene. This gene is located in the surfeit gene cluster, a group of very tightly linked genes that do not share sequence similarity. The gene demonstrates features of a housekeeping gene, being ubiquitously expressed, and the encoded protein has been localized to the nucleolus. The protein includes motifs found in both the mouse and fish orthologs, which suggests a putative function as a nucleolar-matrix protein with nucleic acid-binding properties, based on characteristics determined in mouse.
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Johanson–Blizzard syndrome is caused by mutations in the UBR1 gene, which encodes one of several ubiquitin ligase enzymes of the N-end rule pathway. The protein ubiquitin is a universal, "ubiquitously" expressed protein common to eukaryotic organisms. Ubiquitin plays a role in the regulation of other proteins by tagging them for eventual degradation by proteasomes. This process begins when ubiquitin ligase covalently attaches a ubiquitin molecule to the lysine side chain of the target protein substrate (the misfolded, damaged, malfunctioning or unneeded protein that needs to be degraded).
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Hollow fiber membranes are ubiquitously used in industrial separations, especially the filtration of drinking water. Hollow fibers are commonly used substrates for specialized bioreactor systems, with the ability of some hollow fiber cartridges to culture billions of anchorage- dependent cells within a relatively low (<100 mL) bioreactor volume. Hollow fibers can be used for drug efficacy testing in cancer research, as an alternative to the traditional, but more expensive, xenograft model. A longitudinal cross section of a polysulfone hollow fiber membrane intraluminally cultured with 3T3 fibroblasts and stained with DAPI.
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This gene is expressed ubiquitously in cancer cell lines and primary tumors and, like other members of this family, may be involved in tumorigenesis. For instance, cathepsin Z promotes invasion and migration via a noncatalytic mechanism, suggesting multiple modes of cell invasion may be involved in cancer malignancy. Cathepsin Z is also reported to have a protective, but not proteolytic, function in inflammatory gastric disease. It is reported in another study that cathepsin Z may be responsible for dopamine neuron death and thus involved in the pathogenic cascade event.
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For instance, it binds less tightly to the cytoskeleton than the other isozymes do, likely due to its more acidic pI. In addition, ALDOC participates in the stress-response pathway for lung epithelial cell function during hypoxia and in the resistance of cerebellar Purkinje cells against excitotoxic insult. ALDOC is ubiquitously expressed in most tissues, though it is predominantly expressed in brain, smooth muscle, and neuronal tissue. However, since the ALDOA isoform is co-expressed with ALDOC in the central nervous system (CS), it is suggested that ALDOC contributes to CNS function outside of glycolysis.
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Human DNA has about 80–90% of CpG sites methylated, but there are certain areas, known as CpG islands, that are CG-rich (high cytosine and guanine content, made up of about 65% CG residues), wherein none is methylated. These are associated with the promoters of 56% of mammalian genes, including all ubiquitously expressed genes. One to two percent of the human genome are CpG clusters, and there is an inverse relationship between CpG methylation and transcriptional activity. Methylation contributing to epigenetic inheritance can occur through either DNA methylation or protein methylation.
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The reverse reaction generates succinyl-CoA from succinate to fuel ketone body and heme synthesis. While SCS is ubiquitously expressed, SUCLG2 is predominantly expressed in tissues involved in biosynthesis, including liver and kidney. SUCLG2 has also been detected in the microvasculature of the brain, likely to support its growth. Notably, both SUCLA2 and SUCLG2 are absent in astrocytes, microglia, and oligodendrocytes in the brain; thus, in order to acquire succinate to continue the TCA cycle, these cells may instead synthesize succinate through GABA metabolism of α-ketoglutarate or ketone body metabolism of succinyl-CoA.
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Talin-1 is a protein that in humans is encoded by the TLN1 gene. Talin-1 is ubiquitously expressed, and is localized to costamere structures in cardiac and skeletal muscle cells, and to focal adhesions in smooth muscle and non- muscle cells. Talin-1 functions to mediate cell-cell adhesion via the linkage of integrins to the actin cytoskeleton and in the activation of integrins. Altered expression of talin-1 has been observed in patients with heart failure, however no mutations in TLN1 have been linked with specific diseases.
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This gene is ubiquitously expressed and is involved in the transcriptional coactivation of many different transcription factors. First isolated as a nuclear protein [Ref] that binds to cAMP-response element-binding protein (CREB), this gene is now known to play critical roles in embryonic development, growth control, and homeostasis by coupling chromatin remodeling to transcription factor recognition. The protein encoded by this gene has intrinsic histone acetyltransferase activity and also acts as a scaffold to stabilize additional protein interactions with the transcription complex. This protein acetylates both histone and non-histone proteins.
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The stromal cell-derived factor 1 (SDF1), also known as C-X-C motif chemokine 12 (CXCL12), is a chemokine protein that in humans is encoded by the CXCL12 gene on chromosome 10. It is ubiquitously expressed in many tissues and cell types. Stromal cell-derived factors 1-alpha and 1-beta are small cytokines that belong to the chemokine family, members of which activate leukocytes and are often induced by proinflammatory stimuli such as lipopolysaccharide, TNF, or IL1. The chemokines are characterized by the presence of 4 conserved cysteines that form 2 disulfide bonds.
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Tribbles homolog 1 is a protein kinase that in humans is encoded by the TRIB1 gene. Orthologs of this protein pseudokinase (pseudoenzyme) can be found almost ubiquitously throughout the animal kingdom. It exerts its biological functions through binding to signalling proteins of the MAPKK level of the MAPK pathway, therefore eliciting a regulatory role in the function of this pathway which mediates proliferation, apoptosis and differentiation in cells. Tribbles-1 is encoded by the trib1 gene, which in humans can be found on chromosome 8 at position 24.13 on the longest arm (q).
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Zhong Kui with the wufu as represented by five bats, in a late 19th or early 20th century xylograph Wufu (), meaning the five blessings, is a concept that signify a grouping of certain good fortunes and luck in Chinese culture. The number five is regarded as an auspicious number in Chinese traditions and closely associated with the Five Elements (Wu Xing, ), which are essential for a good life as well as the basic organisational principle in Chinese thought. As a result, the number five appears ubiquitously as in the Five Blessings.
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Non-peptidic antigens are low-molecular-weight compounds that stimulate human Vγ9/Vδ2 T cells. The most potent activator for Vγ9/Vδ2 T cells is (E)-4-hydroxy-3-methyl-but-2-enyl pyrophosphate (HMB-PP), a natural intermediate of the non-mevalonate pathway of isopentenyl pyrophosphate (IPP) biosynthesis. HMB-PP is an essential metabolite in most pathogenic bacteria including Mycobacterium tuberculosis as well as in malaria parasites, but is absent from the human host. IPP itself is structurally closely related to HMB- PP and ubiquitously present in all living cells (i.e.
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He popularized a system of analyzing the layers of a site in order to compile a complete understanding of the qualitative attributes of a place. This system became the foundation of today's Geographic Information Systems (GIS). McHarg would give every qualitative aspect of the site a layer, such as the history, hydrology, topography, vegetation, etc. GIS software is ubiquitously used in the landscape architecture profession today to analyze materials in and on the Earth's surface and is similarly used by urban planners, geographers, forestry and natural resources professionals, etc.
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As a member of the FASTKD family, FASTKD5 localizes to the mitochondria to modulate their energy balance, especially under conditions of stress. Though ubiquitously expressed in all tissues, FASTKD5 appears more abundantly in skeletal muscle, heart muscle, and other tissues enriched in mitochondria. FASTKD5 also localizes to RNA granules, membraneless bodies containing mRNAs and associated RNA-binding proteins, where it facilitates posttranscriptional RNA processing. This protein is required for the maturation of precursor mRNAs that are not flanked by tRNAs, and thus cannot be processed by the canonical mRNA maturation pathway.
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Von Hippel–Lindau binding protein 1 (VBP1), also known as "prefoldin 3", is a chaperone protein that binds to von Hippel–Lindau protein and transports it from perinuclear granules to the nucleus or cytoplasm inside the cell. It is also involved in transporting nascent polypeptides to cytosolic chaperonins for post-translational folding. VBP1 is a 197–amino acid heterohexamer comprising two prefoldin-α and four prefoldin-β subunits, and is a member of the prefoldin-α subunit family. It is ubiquitously expressed in tissues, and is located in the cell in the nucleus and cytoplasm.
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TMEM18 seems to affect energy levels through insulin and glucagon signaling, and in flies, its downregulation induces a metabolic state resembling type-II diabetes Overexpression of the TMEM18 protein increases the migration capacity of neural stem cells while inactivation of TMEM18 results in almost complete loss of migration activity. The TMEM18 gene is ubiquitously expressed in both mammalian and fly tissues, which suggests a basic cellular function. In the mouse brain, it is found in the majority of all cells, but is more abundant in neurons than other cell types.
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Spiral Tribe also toured the United States towards the late 1990s. According to Spiral Tribe founding member Mark Stormcore, the name came to him when he was at work, staring at a poster of the interconnecting spirals in an ammonite shell. The number 23, which is ubiquitously associated with Spiral Tribe, was introduced by Mark Harrison. Despite allusions to the number having been used by Psychic TV and Robert Anton Wilson, Harrison has stated that it "had nothing to do with any pre-existing individual, group or subculture".
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Expression in various retinal cell types can be determined by the promoter sequence. In order to restrict expression to a specific cell type, a tissue-specific or cell-type specific promoter can be used. For example, in rats the murine rhodopsin gene drive the expression in AAV2, GFP reporter product was found only in rat photoreceptors, not in any other retinal cell type or in the adjacent RPE after subretinal injection. On the other hand, if ubiquitously expressed immediate-early cytomegalovirus (CMV) enhancer-promoter is expressed in a wide variety of transfected cell types.
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Lakoff and Mark Johnson showed that humans use metaphor ubiquitously and that metaphors operate at a conceptual level (i.e., they map one conceptual domain onto another), they involve an unlimited number of individual expressions and that the same metaphor is used conventionally throughout a culture. Lakoff and his collaborators have collected thousands of examples of conceptual metaphors in many domains. For example, people will typically use language about journeys to discuss the history and status of a love affair, a metaphor Lakoff and Johnson call "LOVE IS A JOURNEY".
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Ankyrin-B, also known as Ankyrin-2, is a protein which in humans is encoded by the ANK2 gene. Ankyrin-B is ubiquitously expressed, but shows high expression in cardiac muscle. Ankyrin-B plays an essential role in the localization and membrane stabilization of ion transporters and ion channels in cardiomyocytes, as well as in costamere structures. Mutations in ankyrin-B cause a dominantly- inherited, cardiac arrhythmia syndrome known as ankyrin-B syndrome as well as sick sinus syndrome; mutations have also been associated to a lesser degree with hypertrophic cardiomyopathy.
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Atrophin-1 (ATN1) encodes a hydrophilic 1184 amino acid protein with several repetitive motifs including a serine-rich region, a variable length polyglutamine tract, a polyproline tract, and a region of alternating acidic and basic residues. It contains a putative nuclear localization signal in the N-terminus of the protein and a putative nuclear export signal in the C-terminus. ATN1 is ubiquitously expressed in all tissues, but proteolytically cleaved in neuronal cells. The function of ATN1 is not clear, however it is believed to be a transcriptional co-repressor.
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In principle, pesticides are registered for use only after they are demonstrated not to persist in the environment considerably beyond their intended period of use. Typically, documented soil half-lives are in the range of days to weeks. However, pesticide residues are found ubiquitously in the environment in ng/liter to low μg/liter concentrations. For instance, surveys of groundwater and not-yet-treated potable water in industrialized countries typically detect 10 to 20 substances in recurrent findings above the maximum accepted drinking water concentration for pesticides in many countries.
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The anonymous agent coordination technology for knowledge processors in smart spaces has been proposed and documented.Smirnov, A., Kashevnik, A., Shilov, N., Oliver, I., Lappetelainen, A., Boldyrev, S. Anonymous Agent Coordination in Smart Spaces: State-of-the-Art. Smart Spaces and Next Generation Wired/Wireless Networking (ruSmart 2009), S. Balandin, D. Moltchanov, Y. Koucheryavy (Eds.), Springer, LNCS 5764, pp.42-51. Three examples of the application of this technology have been demonstrated in so called smart home environments,Kary Främling, Ian Oliver, Jukka Honkola, and Jan Nyman (2009) Smart Spaces for Ubiquitously Smart Buildings.
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The tertiary structure of utrophin contains a C-terminus that consists of protein–protein interaction motifs that interact with dystroglycan, a central rod region consisting of a triple coiled-coil repeat, and an actin-binding N-terminus. In normal muscle cells, utrophin is located at the neuromuscular synapse and myotendinous junctions. It is necessary for normal membrane maintenance, and for the clustering of the acetylcholine receptor. In adult humans, utrophin RNA is found ubiquitously, as the name implies, being abundant in the brain, kidney, liver, lung, muscle, spleen and stomach.
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Goethe Basin is considerably older than the Caloris Basin. Emplacement of the smooth plains material of Borealis Planitia during several or many episodes resulted in resurfacing and smoothing of the original material of the Goethe Basin and its surroundings for hundreds of kilometers. The mercurian surface reached its present configuration several billion years ago (Solomon, 1978). It has been only slightly altered since by impact craters, which are ubiquitously superposed on all other deposits. Generalized summaries of the history of Mercury have been given by Guest and O’Donnell (1977), Davies and others, and Strom.
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Kalirin9 and 12 are also expressed ubiquitously throughout the body and have functions outwith the brain. However, during neurodevelopment the kalirin7 isoform is preferentially expressed during periods of synaptogenesis, and this isoform displays highly restricted cortical expression. Kalirin7 expresses only the N-terminal domains, including the Rac-GEF domain along with a c-terminal PDZ-binding domain that strongly targets kalirin7 to the post-synaptic density. It is likely this subcellular distribution is vital to kalirin7 function, as this isoform exerts control dendritic spine density and synaptic plasticity.
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Contacts between the primary biotite monzogranite and the slates and greywackes of the host rocks are ubiquitously sharp and intrusive. Numerous small bodies (<) of fine-grained leucomonzogranite, which constitute less than 0.1% of the total pluton, are scattered throughout it. The plutons of the South Mountain Batholith are estimated to have been emplaced at depths of . The South Mountain Batholith was emplaced within in Late Devonian time, about 370 Ma. It intruded into Cambro-Ordovician metasedimentary rocks of the Meguma Supergroup and the overlying Siluro-Devonian metasedimentary to metavolcanic rocks of the Rockville Notch Group.
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The liver X receptors, LXRα (this protein) and LXRβ, form a subfamily of the nuclear receptor superfamily and are key regulators of macrophage function, controlling transcriptional programs involved in lipid homeostasis and inflammation. Additionally, they play an important role in the local activation of thyroid hormones via deiodinases. The inducible LXRα is highly expressed in liver, adrenal gland, intestine, adipose tissue, macrophages, lung, and kidney, whereas LXRβ is ubiquitously expressed. Ligand-activated LXRs form obligate heterodimers with retinoid X receptors (RXRs) and regulate expression of target genes containing LXR response elements.
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Fig. 1: Strategic disconnection en route to the hops ether Many retrosynthetic disconnections important for organic synthesis planning use carbocationic synthons. Carbon-carbon bonds, for example, exist ubiquitously in organic molecules, and are usually disconnected during a retrosynthetic analysis to yield carbocationic and carbanionic synthons. Carbon-heteroatom bonds, such as those found in alkyl halides, alcohols, and amides, can also be traced backwards retrosynthetically to polar C-X bond disconnections yielding a carbocation on carbon. Oxonium and acylium ions are carbocationic synthons for carbonyl compounds such as ketones, aldehydes and carboxylic acid derivatives.
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It is present in two copies per dynactin complex and forms an ≈75 nm long flexible arm that extends from the main body of dynactin. The p150-glued arm contains binding sites for microtubules, the microtubule plus tip binding protein EB1, and the N-terminus of the dynein intermediate chain. Alternative splicing of this gene results in at least 2 functionally distinct isoforms: a ubiquitously expressed one and a brain-specific one. Based on its cytogenetic location, this gene is considered as a candidate gene for limb- girdle muscular dystrophy.
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S-nitrosoglutathione reductase (GSNOR) is a class III alcohol dehydrogenase (ADH) encoded by the ADH5 gene in humans. It is a primordial ADH that is ubiquitously expressed in plant and animals alike. GSNOR reduces S-nitrosoglutathione (GSNO) to the unstable intermediate, S-hydroxylaminoglutathione, which then rearranges to form glutathione sulfinamide, or in the presence of GSH, forms oxidized glutathione (GSSG) and hydroxyl amine. Through this catabolic process, GSNOR regulates the cellular concentrations of GSNO and plays a central role in regulating the levels of endogenous S-nitrosothiols and controlling protein S-nitrosylation-based signaling.
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In Hungary and Serbia, pea soup is often served with dumplings and spiced with hot paprika. In the United Kingdom, dried, rehydrated and mashed marrowfat peas, or cooked green split peas, known as mushy peas, are popular, originally in the north of England, but now ubiquitously, and especially as an accompaniment to fish and chips or meat pies, particularly in fish and chip shops. Sodium bicarbonate is sometimes added to soften the peas. In 2005, a poll of 2,000 people revealed the pea to be Britain's seventh favourite culinary vegetable.
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Katz's work had a strong influence on another future Nobel Prize winner, Bert Sakmann. He spent two years at UCL in Katz's biophysics laboratory and it was here that he developed his interest in the molecular aspects of synaptic transmission. He went on to directly measure singe ion channel currents by developing the now ubiquitously used patch-clamp technique with Erwin Neher. They shared the 1991 Prize in recognition of their work on the function of single ion channels Neuroscience at UCL has long been a major cross-disciplinary endeavour.
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Filamin-C is a 290.8 kDa protein composed of 2725 amino acids. Filamin-C, like the ubiquitously-expressed isoform Filamin-A, have an N-terminal filamentous actin-binding domain, followed by a lengthy C-terminal self-association domain containing a series of immunoglobulin-like domains, and a membrane glycoprotein-binding domain. Filamin-C interacts with γ-sarcoglycan and δ-sarcoglycan at the sarcolemma; myotilin and FATZ/calsarcin/myozenin at Z-lines, as well as LL5β. Filamin-C has also been shown to interact with INPPL1, KCND2, and MAP2K4.
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Adducins are heteromeric proteins composed of different subunits referred to as adducin alpha, beta, and gamma. The three subunits are encoded by distinct genes and belong to a family of membrane skeletal proteins involved in the assembly of spectrin-actin network in erythrocytes and at sites of cell-cell contact in epithelial tissues. While adducins alpha and gamma are ubiquitously expressed, the expression of adducin beta is restricted to brain and hematopoietic tissues. Adducin, originally purified from human erythrocytes, was found to be a heterodimer of adducins alpha and beta.
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Hume also highlighted the fact/value gap, as what is does not itself reveal what ought.Hume noted that authors ubiquitously continue for some time stating facts and then suddenly switch to stating norms—supposedly what should be—with barely explanation. Yet such values, as in ethics or aesthetics or political philosophy, are not found true merely by stating facts: is does not itself reveal ought. Hume's law is the principle that the fact/value gap is unbridgeable—that no statements of facts can ever justify norms—although Hume himself did not state that.
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K3 surfaces appear almost ubiquitously in string duality and provide an important tool for the understanding of it. String compactifications on these surfaces are not trivial, yet they are simple enough to analyze most of their properties in detail. The type IIA string, the type IIB string, the E8×E8 heterotic string, the Spin(32)/Z2 heterotic string, and M-theory are related by compactification on a K3 surface. For example, the Type IIA string compactified on a K3 surface is equivalent to the heterotic string compactified on a 4-torus ().
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Serum paraoxonase/arylesterase 2 is an enzyme that in humans is encoded by the PON2 gene. This gene encodes a member of the paraoxonase gene family, which includes three known members located adjacent to each other on the long arm of chromosome 7. The encoded protein is ubiquitously expressed in human tissues, membrane-bound, and may act as a cellular antioxidant, protecting cells from oxidative stress. Hydrolytic activity against acylhomoserine lactones, important bacterial quorum-sensing mediators, suggests the encoded protein may also play a role in defense responses to pathogenic bacteria.
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However, ethnic Chinese are constituting an increasingly dominant proportion of the Asian population as well as of the overall population in Flushing and its Chinatown. A 1986 estimate by the Flushing Chinese Business Association approximated 60,000 Chinese in Flushing alone. Mandarin Chinese (including Northeastern Mandarin), Fuzhou dialect, Min Nan Fujianese, Wu Chinese, Beijing dialect, Wenzhounese, Shanghainese, Cantonese, Taiwanese, and English are all prevalently spoken in Flushing Chinatown. The popular styles of Chinese cuisine are ubiquitously accessible in Flushing, including Hakka, Taiwanese, Shanghainese, Hunanese, Szechuan, Cantonese, Fujianese, Xinjiang, Zhejiang, and Korean Chinese cuisine.
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The Gai-As Formation gradationally overlies the lacustrine deposits of the Huab Formation in the western part of the basin, but in the east succeeds the fluvial deposits of the Huab Formation with a sharp contact. The basal beds of the formation are ubiquitously represented by fine-grained distal deposits and imply a much larger extent of the formation due to the absence of sediments from marginal environments.Horsthemke et al, 1990, p.73 The lower part of the succession is formed by approximately of thick reddish-violet, slightly calcareous shales.
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Furthermore, beyond the fact that the hypothesis is still relatively unknown, it also contradicts the current paradigm in molecular evolution, since the neutral theory's fundamental premises are still nearly ubiquitously utilized in genetic analysis and admixture studies. Additionally, some of the phenomena explained by the hypothesis could theoretically be accounted for by other processes such as gene conversion or concerted evolution. Lastly, even if the neutral theory is disproved, it does not necessarily validate the hypothesis, as alternative theories have been proposed that also incorporate the effects of selection on the genome.
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C7orf50 (Chromosome 7, Open Reading Frame 50) is a gene in humans (Homo sapiens) that encodes a protein known as C7orf50 (uncharacterized protein C7orf50). This gene is ubiquitously expressed in the kidneys, brain, fat, prostate, spleen, among 22 other tissues and demonstrates low tissue specificity. C7orf50 is conserved in chimpanzees, Rhesus monkeys, dogs, cows, mice, rats, and chickens, along with 307 other organisms from mammals to fungi. This protein is predicted to be involved with the import of ribosomal proteins into the nucleus to be assembled into ribosomal subunits as a part of rRNA processing.
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The major facilitator superfamily (MFS) are membrane proteins which are expressed ubiquitously in all kingdoms of life for the import or export of target substrates. The MFS family was originally believed to function primarily in the uptake of sugars but subsequent studies revealed that drugs, metabolites, oligosaccharides, amino acids and oxyanions were all transported by MFS family members. These protein energetically drive transport utilizing the electrochemical gradient of the target substrate (uniporter), or act as a cotransporter where transport is coupled to the movement of a second substrate.
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Penicillium spinulosum (spinulosus means with small spines in Latin) is a non- branched, fast-growing fungus with a swelling at the terminal of the stipe (vesiculate) in the genus Penicillium. P. spinulosum is able to grow and reproduce in environment with low temperature and low water availability, and is known to be acidotolerant. P. spinulosum is ubiquitously distributed, and can often be isolated from soil. Each individual strain of P. spinulosum differs from others in their colony morphology, including colony texture, amount of sporulation and roughness of conidia and conidiophores.
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In order to mark GSCs with lacZ gene, flip recombinase (Flp)-mediated recombination is used to combine a ubiquitously active tubulin promoter followed by an FRT (flip recombinase target) site with a promotorless lacZ ORF (open reading frame) preceded by an FRT site. Heat shock is used to induce Flp recombinase marker gene expression is activated in dividing cells due to recombination. Consequently, all clone of cells derived from GSC are marked with a functional lacZ gene. By tracking the marked cells, they were able to show that GSCs do age.
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Big Brother is a fictional character and symbol in George Orwell's dystopian 1949 novel Nineteen Eighty-Four. He is ostensibly the leader of Oceania, a totalitarian state wherein the ruling party Ingsoc wields total power "for its own sake" over the inhabitants. In the society that Orwell describes, every citizen is under constant surveillance by the authorities, mainly by telescreens (with the exception of the Proles). The people are constantly reminded of this by the slogan "Big Brother is watching you": a maxim that is ubiquitously on display.
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The basic technique of stereo displays is to present offset images that are displayed separately to the left and right eye. Both of these 2D offset images are then combined in the brain to give the perception of 3D depth. Although the term "3D" is ubiquitously used, it is important to note that the presentation of dual 2D images is distinctly different from displaying an image in three full dimensions. The most notable difference to real 3D displays is that the observer's head and eyes movements will not increase information about the 3-dimensional objects being displayed.
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552–555 George W. Bush defeated Al Gore in the 2000 election and was re-elected in 2004. Bush and his son thus became the second father–son pair to each serve as President of the United States, following John Adams and John Quincy Adams.Meacham (2015), p. 560 Through previous administrations, the elder Bush had ubiquitously been known as "George Bush" or "President Bush", but following his son's election the need to distinguish between them has made retronymic forms such as "George H. W. Bush" and "George Bush Sr." and colloquialisms such as "Bush 41" and "Bush the Elder" more common.
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Part of the challenge is that the endogamous nature of tribes is also conformed to by the vast majority of Hindu castes. Indeed, many historians and anthropologists believe that caste endogamy reflects the once- tribal origins of the various groups who now constitute the settled Hindu castes. Another defining feature of caste Hindu society, which is often used to contrast them with Muslim and other social groupings, is lineage/clan (or gotra) and village exogamy. However, these in-marriage taboos are also held ubiquitously among tribal groups, and do not serve as reliable differentiating markers between caste and tribe.
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This nuclear gene encodes a mitochondrial member of the thioredoxin family, a group of small multifunctional redox-active proteins. The encoded protein is ubiquitously expressed in all prokaryotic and eukaryotic organisms, but demonstrates especially high expression in tissues with heavy metabolic activity, including the stomach, testis, ovary, liver, heart, neurons, and adrenal gland. It may play important roles in the regulation of the mitochondrial membrane potential and in protection against oxidant-induced apoptosis. Specifically, the ability of TXN2 to reduce disulfide bonds enables the protein to regulate mitochondrial redox and, thus, the production of reactive oxygen species (ROS).
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This gene encodes a member of the subtilisin-like proprotein convertase family, which includes proteases that process protein and peptide precursors trafficking through regulated or constitutive branches of the secretory pathway. The encoded protein undergoes an initial autocatalytic processing event in the endoplasmic reticulum (ER) to generate a heterodimer which exits the ER and sorts to the cis/medial-Golgi where a second autocatalytic event takes place and the catalytic activity is acquired. It encodes a type 1 membrane bound protease which is ubiquitously expressed and regulates cholesterol or lipid homeostasis via cleavage of substrates at non-basic residues.
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Melanoma inhibitory activity protein 3 (MIA3), also known as transport and Golgi organization protein 1 (TANGO1), is a protein that in humans is encoded by the MIA3 gene on chromosome 1. It is ubiquitously expressed in many tissues and cell types. MIA3 localizes to the endoplasmic reticulum (ER) exit site, where it binds bulky cargo molecules such as collagens and creates mega transport carriers for the export of cargoes from the ER. This function suggests that it plays a role in assembly of extracellular matrix (ECM) and bone formation. MIA3 has been demonstrated to contribute to both tumor suppression and progression.
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Lipid phosphate phosphohydrolase 3 (LPP3), also known as phospholipid phosphatase 3 (PLPP3) and phosphatidic acid phosphatase type 2B (PAP-2b or PPAP2B), is an enzyme that in humans is encoded by the PPAP2B gene on chromosome 1. It is ubiquitously expressed in many tissues and cell types. LPP3 is a cell-surface glycoprotein that hydrolyzes extracellular lysophosphatidic acid (LPA) and short-chain phosphatidic acid. Its function allows it to regulate vascular and embryonic development by inhibiting LPA signaling, which is associated with a wide range of human diseases, including cardiovascular disease and cancer, as well as developmental defects.
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Lemper, named Billboard's Crossover Artist of the Year for 1993/1994, is a prolific recording artist, appearing on numerous cast recordings and compilation concerts, including Roger Waters' The Wall concert in 1990. As a solo artist, her extensive discography includes ubiquitously well-reviewed interpretations of Kurt Weill's compositions from the late 1980s, in addition to German cabaret songs, which were very political songs sung in underground locations in 1930s Berlin and elsewhere. She recorded Illusions in 1992, devoted to the songs of Marlene Dietrich and Édith Piaf. She has numerous pop albums, variously in English, French, and German.
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The protein encoded by this ubiquitously expressed gene interacts with the tumor suppressing BRCA1 (breast cancer 1) protein and the ATM (ataxia telangiectasia mutated) protein. ATM is thought to be a master controller of cell cycle checkpoint signalling pathways that are required for cellular responses to DNA damage such as double-strand breaks that are induced by ionizing radiation and complexes with BRCA1 in the multi-protein complex BASC (BRAC1-associated genome surveillance complex). The protein encoded by this gene is thought to play a role in the DNA damage pathway regulated by BRCA1 and ATM.
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Multiple studies have established that Nodal signal is required for the induction of most mesodermal and endodermal cell types and Squint/Cyclops knockouts in Zebrafish do not develop notochord, heart, kidneys or even blood. The origin and expression pattern of the nodal signaling proteins differs in different species. Mammalian nodal signaling is initiated ubiquitously in epiblast cells and is maintained by autoregulatory signaling of Wnt3 and limited by the induction of antagonists such as Cerberus-like and lefty. Studies in Xenopus have found that xnr expression (the Xenopus nodal) is induced by VegT at the vegetal pole and nodals spread to the blastula.
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As a member of the FASTKD family, FASTKD2 localizes to the inner mitochondrial membrane to modulate their energy balance, especially under conditions of stress. Though ubiquitously expressed in all tissues, FASTKD2 appears more abundantly in skeletal muscle, heart muscle, and other tissues enriched in mitochondria. Nonetheless, FASTKD2 has been observed to mediate apoptosis independent of import into the mitochondria, suggesting that it interacts with proteins on the outer mitochondrial membrane. This protein possibly contributes its proapoptotic function through a caspase-dependent pathway, by activating proapoptotic factors or inhibiting antiapoptotic factors, but the exact mechanism remain unclear.
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Even though no group publicly advocated in its favor during the unrest that lead to the resignation of Ricardo Rosselló in July 2019, the circle-A was ubiquitously found among other protest graffiti painted throughout Old San Juan. Faced with more conflict with the government, anarchist activities in Puerto Rico were taken underground. Whereas they would rely on propaganda and newspaper during the movement's heyday, they would leave little to no paper trail behind after the events that unfolded during the 1920s. Capetillo died in 1922, an event that diminished the local anarchists due to her popularity.
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This fanciful name for the virtual space created by a global network of interconnected computers is Moran’s extrapolation of what the Internet would become. Aside from its everyday uses in his stories it also provides another environment in which good and evil can do battle. Surprisingly, the most significant battle in the series is a fight against excessive governmental control of this fundamental quasi-public space. As part of Moran’s description of how a ubiquitously available Internet would affect society (The Long Run, 1989), he introduced the concept of Internet addiction disorder, which he called “data-starve”.
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A programming tool or software development tool is a computer program that software developers use to create, debug, maintain, or otherwise support other programs and applications. The term usually refers to relatively simple programs, that can be combined together to accomplish a task, much as one might use multiple hand tools to fix a physical object. The most basic tools are a source code editor and a compiler or interpreter, which are used ubiquitously and continuously. Other tools are used more or less depending on the language, development methodology, and individual engineer,often used for a discrete task, like a debugger or profiler.
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BLOC-1 or biogenesis of lysosome-related organelles complex 1 is a ubiquitously expressed multisubunit protein complex in a group of complexes that also includes BLOC-2 and BLOC-3. BLOC-1 is required for normal biogenesis of specialized organelles of the endosomal-lysosomal system, such as melanosomes and platelet dense granules. These organelles are called LROs (lysosome-related organelles) which are apparent in specific cell-types, such as melanocytes. The importance of BLOC-1 in membrane trafficking appears to extend beyond such LROs, as it has demonstrated roles in normal protein- sorting, normal membrane biogenesis, as well as vesicular trafficking.
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The teletext-like "Mode 7" display mode inside the 8-bit BBC Micros made a broadcast teletext adapter an obvious expansion, and the BBC would broadcast telesoftware free over Ceefax. The hardware and software design was created by Graham Toal. The initial software to use the adapter was quite basic but the BBC decided to rewrite it and produced the Advanced Teletext System. This new ROM added several new features including support for the new Fastext system, which introduced the four coloured buttons subsequently found almost ubiquitously on European remote controls, including the "red button" which remains a feature of digital television broadcasting.
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Zeman and Lackner outlined a specific method of air capture. First, CO2 is absorbed by an alkaline NaOH solution to produce dissolved sodium carbonate. The absorption reaction is a gas liquid reaction, strongly exothermic, here: :2NaOH(aq) + CO2(g) → Na2CO3(aq) + H2O(l) :Na2CO3(aq) + Ca(OH)2(s) → 2NaOH(aq) + CaCO3(s) :ΔH° = -114.7 kJ/mol Causticization is performed ubiquitously in the pulp and paper industry and readily transfers 94% of the carbonate ions from the sodium to the calcium cation. Subsequently, the calcium carbonate precipitate is filtered from solution and thermally decomposed to produce gaseous CO2.
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Chinese honorifics and honorific language (，，，，) are words, word constructs, and expressions in the Chinese language that convey self-deprecation, social respect, politeness, or deference. Once ubiquitously employed in ancient China, a large percent has fallen out of use in the contemporary Chinese lexicon. The promotion of vernacular Chinese during the New Culture Movement () of the 1910s and 1920s in China further hastened the demise of a large body of Chinese honorifics previously preserved in the vocabulary and grammar of Classical Chinese. Although Chinese honorifics have simplified to a large degree, contemporary Chinese still retains a sizable set of honorifics.
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Myc box-dependent-interacting protein 1, also known as Bridging Integrator-1 and Amphiphysin-2 is a protein that in humans is encoded by the BIN1 gene. This gene encodes several isoforms of a nucleocytoplasmic adaptor protein, one of which was initially identified as a MYC-interacting protein with features of a tumor suppressor. Isoforms that are expressed in the central nervous system may be involved in synaptic vesicle endocytosis and may interact with dynanim, synaptojanin, endophilin, and clathrin. Isoforms that are expressed in muscle and ubiquitously expressed isoforms localize to the cytoplasm and nucleus and activate a caspase-independent apoptotic process.
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DQ8 along with a few other haplotypes appears to be split NW/SE in Eurasia and with the evidence for DQ2.5 and other haplotypes suggest an ancient Central Asian population was displaced by a more recent African migration. There are many common markers found in France, Germans, Danes, Swedes, Tibetans, Amur River, Japanese and Koreans that are potential indicators of this bilateral spread. The DQ8 haplotypes is found at high frequencies in the !Kung, albeit one expects more DQ8 in Austronesia it is ubiquitously spread if at some times low frequencies, other times higher frequencies (Thai).
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Since nearly all of the glycolytic reactions upstream of PEP and downstream of glucose-6-phosphate (G6P) are reversible, PCK2-mediated synthesis of PEP could fuel multiple biosynthetic processes, such as serine synthesis, glycerol synthesis, and nucleotide synthesis. Notably, PCK2 preferentially converts OAA derived from lactate and, thus, can promote biosynthesis even under low-glucose conditions. As a result, PCK2 activity contributes to cell growth and survival during stress. While PCK1 is mainly expressed in the liver and kidney, PCK2 is ubiquitously expressed in various cell types, including leukocytes and neurons, as well as in non-gluconeogenic tissues, including pancreas, brain, heart.
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Still, it is not known whether TADs are an adaptive strategy to enhance regulatory interactions or an effect of the constrains on these same interactions. TAD boundaries are often composed by housekeeping genes, tRNAs, other highly expressed sequences and Short Interspersed Elements (SINE). While these genes may take advantage of their border position to be ubiquitously expressed, they are not directly linked with TAD edge formation. The specific molecules identified at boundaries of TADs are called insulators or architectural proteins because they not only block enhancer leaky expression but also ensure an accurate compartmentalization of cis-regulatory inputs to the targeted promoter.
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In humans, this gene is ubiquitously expressed at a fairly low level, approximately 0.6 times the expression of the average gene. Keeping that in mind, this gene is expressed the most in the heart. There is some expression in other areas such as the reproductive organs and the brain, but it is much less. When it comes to the common mouse Mus musculus, the expression of the KRBA1 gene occurs in different areas of the body compared to humans. In mice, the highest expression isn’t in the heart but in the reproductive organs along with the adrenal gland and thymus.
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Based on this information, it is likely that CCDC130 plays a similar role in the human spliceosome, but due to the higher complexity of the human spliceosome, this protein may perform other functions or a completely different function. Due to its high number of phosphorylation sites, it is likely that this protein is activated and recruited to the spliceosomal complex through phosphorylation or dephosphorylation (see Post-translational modifications). Since this gene is ubiquitously expressed and expressed 2.9 times higher than the average gene, it is clear that this protein plays an integral part in the proper function of the spliceosome.
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These two sub-groups can be identified in the accompanying image of the rat, but it can also be seen that there is no clear physical boundary between them. This difficulty in delineating the sub-groups visually is reflected by similarly weak boundaries between them in anatomical and functional parameters, though the distinction is nonetheless referred to ubiquitously in scientific literature and is considered useful in analysis. Apart from cranial vibrissae, other groups are found elsewhere on the body. Many land mammals, including domestic cats, also have carpal (of the wrist) vibrissae on the underside of the leg just above the paws.
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The receptor used for cell entry is alpha-dystroglycan, a highly conserved and ubiquitously expressed cell surface receptor for extracellular matrix proteins. Dystroglycan, which is later cleaved into alpha-dystroglycan and beta- dystroglycan is originally expressed in most cells to mature tissues, and it provides molecular link between the ECM and the actin-based cytoskeleton. After the virus enters the cell by alpha-dystroglycan mediated endocytosis, the low-pH environment triggers pH-dependent membrane fusion and releases RNP (viral ribonucleoprotein) complex into the cytoplasm. Viral RNA is unpacked, and replication and transcription initiate in the cytoplasm.
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The species is known as the sungazer because of its distinctive thermoregulatory behaviour of elevating the anterior parts of the body by extending its fore limbs, usually near the entrance of its burrow as if looking at the sun. The species is well known throughout its distribution, and is called by several different common names, in different languages. The most common local name is ouvolk, given by Afrikaans landowners who liken the thermoregulatory basking position of the species to retired farmworkers, who spend much of their days sitting in the sunlight. The sungazer is also known ubiquitously as pPathakalle by Sotho- speaking people and mbedla by Zulu-speaking people.
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BCAR1 is a ubiquitously expressed adaptor molecule originally identified as the major substrate of v-Src and v-Crk . p130Cas/BCAR1 belongs to the Cas family of adaptor proteins and can act as a docking protein for several signalling partners. Due to its ability to associate with multiple signaling partners, p130Cas/BCAR1 contributes to the regulation to a variety of signaling pathways leading to cell adhesion, migration, invasion, apoptosis, hypoxia and mechanical forces. p130Cas/BCAR1 plays a role in cell transformation and cancer progression and alterations of p130Cas/BCAR1 expression and the resulting activation of selective signalling are determinants for the occurrence of different types of human tumors.
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These two variants are proposed to be the products of separate promoters and not to be splice variants from a single promoter. They are differentially expressed in normal tissues, one of which (variant 2) is expressed at significant levels only in the pancreas, whereas another one (variant 1) is expressed more ubiquitously with highest levels in adult kidney, placenta, brain, heart, and spleen. WNT16B expression is regulated by nuclear factor of κ light polypeptide gene enhancer in B cells 1 (NF-κB) after DNA damage, as can occur to normal cells during radiation or chemotherapy. Subsequently WNT16B signals in a paracrine manner to activate the Wnt expression program in tumor cells.
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The UBE2Z gene is ubiquitously expressed in human tissues, and its expression is relatively high in placenta, pancreas, spleen and testis. Notably, its expression in cancer tissues is much higher than in relevant normal tissues, especially in kidney, lymph node, colon and ovary cancer. As an E2 member of the ubiquitin-conjugating enzyme family, UBE2Z mainly participates in the second step of protein ubiquitination, which is a major component of protein degradation machinery. Specifically, UBE2Z receives ubiquitin (Ub) from ubiquitin-activating enzyme (E1), mediates the transfer of Ub from E2 to substrate, directly or indirectly with the help of ligase enzyme (E3), which interacts with the substrate and E2-Ub complex.
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For the promotion of the album, the band adopted a stark new appearance, designed in consultation with theatre designer Ian McNeil. Now, the duo ubiquitously appeared wearing thick, dark eyebrows, inspired by Kabuki theatre; yellow or orange wigs in a variety of hairstyles, inspired by the punk subculture (especially several spiked wigs); and black sunglasses. This was supported by a series of outfits in dark, muted colours, the most deviant of which incorporated culottes, inspired by the attire of samurai, instead of trousers. Photographs involving the costumes were often set in urban environments; the Midland Grand Hotel in Kings Cross, London was used as the setting to debut the look.
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However, the direct relationship that duplication processes have with modularity has yet to be directly examined. [3] Stabilizing selection: While seeming antithetical to forming novel modules, Wagner maintains that it is important to consider the effects of stabilizing selection as it may be "an important counter force against the evolution of modularity". Stabilizing selection, if ubiquitously spread across the network, could then be a "wall" that makes the formation of novel interactions more difficult and maintains previously established interactions. Against such strong positive selection, other evolutionary forces acting on the network must exist, with gaps of relaxed selection, to allow focused reorganization to occur.
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The Late Miocene oil-producing Nestos-Prinos basin is located between Thassos island and the mainland. The floor of the basin is around 1,500 m deep off the Thassos coast (South Kavala ridge; Proedrou, 1988) and up to 4.000–5.000 m in the axial sector between Thassos and the mainland. The basin is filled with Late Miocene-Pliocene sediments, including ubiquitously repeated evaporite layers of rock salt and anhydrite-dolomite that alternate with sandstones, conglomerates, black shales, and uraniferous coal measures (Proedrou, 1979, 1988; Taupitz, 1985). Stratigraphically equivalent rocks on the mainland are clastic sediments with coal beds, marine to brackish fluvial units and travertines.
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Victor used the trademark far more ubiquitously than its UK affiliate. Magazine and newspaper advertisements urged buyers to "look for the dog." Victor erected a large illuminated advertising sign of Nipper on Broadway, near the Metropolitan Opera House in New York City. In 1915, Victor installed stained glass windows depicting the logo in the tower of Building 17 of its manufacturing complex and headquarters in Camden, New Jersey; the building and windows remain today, and have long been an iconic symbol of both RCA Victor and of Camden's industrial heritage. In British Commonwealth countries, the Gramophone Company did not use the dog on its record labels until 1909.
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Shǒuwēn () was a 9th-century Buddhist Chinese monk credited with the invention of the analysis of Middle Chinese as having 36 initials, later ubiquitously used by the rime tables. However, the Dunhuang fragment Pelliot chinois 2012, held at the Bibliothèque Nationale de France, which operates using an earlier tradition of 30 initials, credits him as his author. Pulleyblank, noting that this fragment does recognize a distinction between labial stops and labiodental fricatives despite not enumerating the latter among the 30 initials, suspects that Shǒuwēn out of deference to the Qieyun tradition decided not to list these initials although he clearly recognized them.Pulleyblank, Edwin G. 1970.
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MIF4GD is found only in animals, and is expressed ubiquitously in the body, though it has been discovered to be expressed at a somewhat higher rate in lymph nodes, bone marrow and testes. MIF4GD is expressed at an average rate that is 1.7 times higher than the average gene. The promoter region of MIF4GD is approximately 1137 nucleotide base pairs long, and is predicted to interact with various transcription factors. The 5' untranslated region of MIF4GD mRNA transcripts is relatively short, at a length of around 137 nucleotides, and is predicted to form stem-loops and interior-loops to which RNA-binding proteins may bind.
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GHITM is a mitochondrial protein and a member of the TMBIM family and BAX inhibitor-1 (BI1) superfamily. It is ubiquitously expressed but is especially abundant in the brain, heart, liver, kidney, and skeletal muscle and scarce in the intestines and thymus. This protein localizes specifically to the IMM, where it regulates apoptosis through two separate processes: (1) the BAX-independent management of mitochondrial morphology and (2) the release of cytochrome c. In the first process, GHITM maintains cristae organization, and its downregulation results in mitochondrial fragmentation, possibly through inducing fusing of the cristae structures, thus leading to the release of proapoptotic proteins such as cytochrome c, Smac, and Htra2.
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In mammals talin-1 is ubiquitously expressed; talin-1 is found complexed to integrins and localized to intercalated discs of cardiac muscle and to costamere structures of both skeletal and cardiac muscles, in correspondence with the I-band and M-line. Talin-1 is also found at focal adhesions of smooth muscle cells and non- muscle cells. In undifferentiated cultures of myoblasts, talin-1 expression is perinuclear, and then progresses to a cytoplasmic distribution followed by a sarcomlemmal, costameric-like pattern by day 15 of differentiation. Homozygous disruption of TLN1 in mice is embryonic lethal, demonstrating that talin-1 is required for normal embryogenesis.
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Found ubiquitously, V. paradoxus has been isolated from a diverse range of environments including soil, the rhizosphere of numerous plant species, drinking water, ground water, freshwater iron seeps, ferromanganese deposits in carbonate cave systems, deep marine sediments, silver mine spoil, gold-arsenopyrite mine drainage water, rubber tyre leachate and surface snow. In particularly, V. paradoxus is abundant in numerous environments that are contaminated with either recalcitrant organic compounds or heavy metals. V. paradoxus is also commonly found in plant rhizosphere communities and is a known plant growth-promoting bacterium (PGPB). It is from these two types of environments that V. paradoxus has been most extensively studied.
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Structurally, hepaCAM is a glycoprotein containing an extracellular domain with 2 Ig-like loops, a transmembrane region and a cytoplasmic domain. Matched to chromosome 11q24, gene HEPACAM is ubiquitously expressed in normal human tissues, with particularly high expression levels in the central nervous system (CNS), and is frequently suppressed in a variety of tumour types. Functionally, hepaCAM is involved in cell-extracellular matrix interactions and growth control of cancer cells, and is able to induce differentiation of glioblastoma cells. In cell signaling, hepaCAM directly interacts with F-actin and calveolin 1, and is capable of inducing senescence-like growth arrest via a p53/p21-dependent pathway.
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Glutamate functions as a neurotransmitter in every type of animal that has a nervous system, including ctenophores (comb jellies), which branched off from other phyla at an early stage in evolution and lack the other neurotransmitters found ubiquitously among animals, including serotonin and acetylcholine. Rather, ctenophores have functionally distinct types of ionotropic glutamate receptors, such that activation of these receptors may trigger muscle contraction and other responses. Sponges do not have a nervous system, but also make use of glutamate for cell-to-cell signalling. Sponges possess metabotropic glutamate receptors, and application of glutamate to a sponge can trigger a whole-body response that sponges use to rid themselves of contaminants.
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The first dynasty to be described in Chinese historical records is the Xia dynasty (c. 2070–1600 BCE), established by Yu the Great after Emperor Shun abdicated leadership to reward Yu's work in taming the Great Flood. Yu's son, Qi, managed to not only install himself as the next ruler, but also dictated his sons as heirs by default, making the Xia dynasty the first in recorded history where genealogical succession was the norm. The civilizational prosperity of the Xia dynasty at this time is thought to have given rise to the name "Huaxia" (, "the magnificent Xia"), a term that was used ubiquitously throughout history to define the Chinese nation.
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Expression level: OCC-1 has moderate to high expression throughout the body, therefore OCC-1 is ubiquitously expressed in humans; notably high expression in the kidney, skeletal muscle and pancreas and low expression in the heart. OCC-1 has shown to be overexpressed in various colon carcinomas. In regards to homologous expression, in situ hybridization data revealed that OCC-1 is expressed in the primary visual cortex of the macque, in an activity dependent manner. Disease state expression: Profiles from NCBI UniGene show the expression of OCC-1 in adrenal tumors, chondrosarcoma, gastrointestinal tumors, kidney tumors, leukemia, liver tumors, prostate cancer, soft tissue/muscle tissue tumors, and uterine tumors.
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The HK1 gene spans approximately 131 kb and consists of 25 exons. Alternative splicing of its 5’ exons produces different transcripts in different cell types: exons 1-5 and exon 8 (exons T1-6) are testis-specific exons; exon 6, located approximately 15 kb downstream of the testis-specific exons, is the erythroid-specific exon (exon R); and exon 7, located approximately 2.85 kb downstream of exon R, is the first 5’ exon for the ubiquitously expressed HK1 isoform. Moreover, exon 7 encodes the porin- binding domain (PBD) conserved in mammalian HK1 genes. Meanwhile, the remaining 17 exons are shared among all HK1 isoforms.
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Transgenic mice over-expressing the EGF- like ligand betacellulin (BTC) exhibit increased cortical bone deposition; however, because the transgene is ubiquitously expressed in these mice, the identity of cells affected by BTC and responsible for increased cortical bone thickness remains unknown. We have therefore examined the influence of BTC upon mesenchymal stem cell (MSC) and pre-osteoblast differentiation and proliferation. BTC decreases the expression of osteogenic markers in both MSCs and pre-osteoblasts increases in proliferation require hypoxia-inducible factor-alpha (HIF-alpha), as an HIF antagonist prevents BTC-driven proliferation. Both MSCs and pre-osteoblasts express EGF receptors ErbB1, ErbB2, and ErbB3, with no change in expression under osteogenic differentiation.
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MID1 is nearly ubiquitously expressed in all embryonic tissues, having an important function during development. Several model organisms have been used to study the expression pattern of MID1 transcript at different times of gestation: mouse, chicken, xenopus and also human embryos. At the very early stage of embryonic development, MID1 is expressed in the primitive node where MID1 plays a pivotal role in establishing the molecular asymmetry at the node, which is crucial for the early definition of the laterality as embryonic development progresses. Later in embryogenesis, at the neurulation stage, MID1 transcript is mainly observed in the cranial region of the developing neural folds.
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Ion permeability appears to occur through a pathway different than that used for water/glycerol transport and may involve a channel at the 4 subunit interface rather than the channels through the subunits. MIP family members are found ubiquitously in bacteria, archaea and eukaryotes. Phylogenetic clustering of the proteins is primarily based according to phylum of the organisms of origin, but one or more clusters are observed for each phylogenetic kingdom (plants, animals, yeast, bacteria and archaea). MIPs are classified into five subfamilies in higher plants, including plasma membrane (PIPs), tonoplast (TIPs), NOD26-like (NIPs), small basic (SIPs) and unclassified X (XIPs) intrinsic proteins.
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The ABL1 proto-oncogene encodes a cytoplasmic and nuclear protein tyrosine kinase that has been implicated in processes of cell differentiation, cell division, cell adhesion, and stress response. Activity of ABL1 protein is negatively regulated by its SH3 domain, and deletion of the SH3 domain turns ABL1 into an oncogene. The t(9;22) translocation results in the head-to-tail fusion of the BCR and ABL1 genes, leading to a fusion gene present in many cases of chronic myelogenous leukemia. The DNA-binding activity of the ubiquitously expressed ABL1 tyrosine kinase is regulated by CDC2-mediated phosphorylation, suggesting a cell cycle function for ABL1.
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Currently, the role of the pro-region is unknown although it has been hypothesised that it may act as an intramolecular chaperone, ensuring correct folding or deactivating activity until PE insertion in the cell wall is complete. Recently, particular attention has been devoted to molecular studies of pectinesterase leading to the characterisation of several related isoforms in various higher plant species. Some of these pectinesterases were shown to be ubiquitously expressed, whereas others are specifically expressed during fruit ripening, germination of the pollen grain, or stem elongation. Such data suggests that pectinesterses are encoded by a family of genes that are differentially regulated in cell type in response to specific developmental or environmental cues.
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Potential layout of the zinc finger protein 800 with significant regions highlighted, such as conserved areas of unknown function in grey, zinc finger regions in green, and unstructured region upstream of the zinc finger in blue. ZNF800 is ubiquitously expressed in at least 27 different tissues, with the largest amounts in bone marrow, testis, and lymph nodes. The ZNF800 protein contains 6 C2H2 zinc finger regions, 4 of which are conserved in paralogs, and 5 of which are conserved in orthologs of ZNF800. It also has two larger regions of unknown function, which are conserved in orthologs, and several key amino acids, the function of which in this particular protein has not yet been discovered.
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There are four distinct types of CK subunits in the tissue of mammals, which are expressed species specifically, developmental stage specifically, and tissue specifically. Ubiquitously expressed, CKMT1A is located in the mitochondrial intermembrane space and form both homodimeric and homooctameric molecules that are readily interconvertible. Like all the other CK isoenzymes, CKMT1A catalyzes the reversible transfer of the γ-phosphate group of ATP to the guanidino group of Cr to yield ADP and PCr. According to the “transport” (“shuttle”) hypothesis for the CK system, after synthesis within the mitochondrial matrix, the γ-phosphate group of ATP is transferred by CKMT1A in the mitochondrial intermembrane space to Cr to yield ADP plus PCr.
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Overview of TERRA Telomeric repeat-containing RNA (TERRA) is a long non-coding RNA transcribed from telomeres - repetitive nucleotide regions found on the ends of chromosomes that function to protect DNA from deterioration or fusion with neighboring chromosomes. TERRA has been shown to be ubiquitously expressed in almost all cell types containing linear chromosomes - including humans, mice, and yeasts. While the exact function of TERRA is still an active area of research, it is generally believed to play a role in regulating telomerase activity as well as maintaining the heterochromatic state at the ends of chromosomes. TERRA interaction with other associated telomeric proteins has also been shown to help regulate telomere integrity in a length- dependent manner.
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Tishkoff and colleagues examined the diversity of the malarial-susceptible locus, ICAM-1, and found greater variation within African populations compared to variation in other global populations. They also found several alleles at the locus that were found ubiquitously in malarial regions, and one of them, “ICAM-1Kilifi,” was present in high frequencies in Asian and African populations. This research suggested that there is a strong association between these allele frequencies and the presence of malaria, and that its analysis would help to find factors that affect malarial susceptibility and resistance. In the same year, Tishkoff proposed that an adaptation to one infectious disease can make humans more susceptible to other diseases.
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In late 2019, Bassil became the subject of a popular Arabic-language chant in the Lebanese protests. The chant was oppositional in nature, due to Bassil's close association to his father-in-law, Lebanese president Michel Aoun, as well as the public perception that Bassil profited politically by taking advantage of the country's sectarian divisions. The lyrics to the chant, which was sung as a short melody, went as follows: These explicit lyrics curse Bassil with a vulgar reference to his mother's genitals. The song was sung in the street and was reproduced and parodied in various forms in popular social media posts and mass-forwarded WhatsApp messages until it was nearly ubiquitously known in Lebanon.
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After the death of Rudolph I at Germersheim on 15 July 1291, his son Albert I was to be the most suitable successor to the throne of the Holy Roman Empire. However, Albert's undignified personality (ubiquitously called "Albert the One-Eyed", due to an open eye socket from a battle injury;) and his bad attitude dismayed the prince electors. Mostly, though they feared too strong a kingship of the son of former king Rudolph I, who controlled one of the strongest domestic power bases in the empire. At the Imperial Diet near Frankfurt the following year, they resolved to elect Adolf of Nassau-Weilburg, a cousin of one of the electors, a man with very little domestic power.
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Usually, these events are caused by a breakage in the DNA double helices at two different locations, followed by a rejoining of the broken ends to produce a new chromosomal arrangement of genes, different from the gene order of the chromosomes before they were broken. Structural chromosomal abnormalities are estimated to occur in around 0.5% of newborn infants. Some chromosomal regions are more prone to rearrangement than others and thus are the source of genetic diseases and cancer. This instability is usually due to the propensity of these regions to misalign during DNA repair, exacerbated by defects of the appearance of replication proteins (like FEN1 or Pol δ) that ubiquitously affect the integrity of the genome.
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Maurer's classification of Germanic dialects Mauer asserted that the cladistic tree model, which was used ubiquitously in linguistics in the 19th and the early 20th centuries, was too inaccurate to describe the relation between the modern Germanic languages, especially those belonging to its Western branch. Rather than depicting Old English, Old Dutch, Old Saxon, Old Frisian and Old High German to have simply 'branched off' a single common 'Proto-West Germanic', which many previous linguists equated to "Old German / Urdeutsch", he assumed that there had been much more distance between certain dialectal groupings and proto- languages.Johannes Hoops, Heinrich Beck, Dieter Geuenich, Heiko Steuer: Reallexikon der germanischen Altertumskunde: Band 7; Walter de Gruyter, 1989, (pp 113–114).
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Specificity of vesicular transport is regulated, in part, by the interaction of a vesicle- associated membrane protein termed synaptobrevin/VAMP with a target compartment membrane protein termed syntaxin. These proteins, together with SNAP25 (synaptosome-associated protein of 25 kDa), form a complex which serves as a binding site for the general membrane fusion machinery. Synaptobrevin/VAMP and syntaxin are believed to be involved in vesicular transport in most, if not all cells, while SNAP25 is present almost exclusively in the brain, suggesting that a ubiquitously expressed homolog of SNAP25 exists to facilitate transport vesicle/target membrane fusion in other tissues. SNAP23 is structurally and functionally similar to SNAP25 and binds tightly to multiple syntaxins and synaptobrevins/VAMPs.
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Goethe was vehemently opposed to Newton's analytic treatment of colour, engaging instead in compiling a comprehensive rational description of a wide variety of colour phenomena. Although the accuracy of Goethe's observations does not admit a great deal of criticism, his aesthetic approach did not lend itself to the demands of analytic and mathematical analysis used ubiquitously in modern Science. Goethe was, however, the first to systematically study the physiological effects of colour, and his observations on the effect of opposed colours led him to a symmetric arrangement of his colour wheel, 'for the colours diametrically opposed to each other... are those which reciprocally evoke each other in the eye. (Goethe, Theory of Colours, 1810).
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WASp, is expressed exclusively in hematopoietic cells and neuronal WASp (N-WASp), is ubiquitously expressed. N-WASp contains an output region and a control region that are essential for its regulation. The output region is called the VVCA domain. It is located towards the C-terminal end of the protein and contains four motifs: two verprolin homology motifs (VV) binds actin monomers and delivers them to Arp2/3; the central domain (C) was once thought to bind cofilin but is now believed to enhance the interactions between the V domains and actin monomers, as well as the interaction between the A domain and Arp2/3; and the acidic motif (A) binds Arp2/3.
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While green has emerged as the color of Taiwan independence and can be seen ubiquitously in pro-independence rallies, at the moment, no one flag has achieved consensus among the various groups. Unlike other political movements, those in Taiwan do not feel there is a historical or local flag suitable for use as a symbol. The flag of the short-lived Republic of Formosa is considered to be unsuitable by some, since that republic was declared by Chinese loyalists and designed as a tributary state in a failed attempt to avert Japanese colonization in 1895. The present national flag, the flag of the Republic of China, is seen by others as a symbol of Chinese nationalism.
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Aly/REF export factor, also known as THO complex subunit 4 is a protein that in humans is encoded by the ALYREF gene. The ALYREF gene encodes Aly/REF export factor (ALY; THO complex subunit 4, Tho4; RNA and export factor binding protein 1, Refbp1), a ubiquitously expressed nuclear protein that functions as a molecular chaperone and export adapter involved in nuclear export of spliced and unspliced mRNA. The TRanscription-EXport (TREX) complex, a key player in mRNA export, includes the THO subcomplex, the RNA helicase UAP56, and the RNA- binding protein ALY. In yeast, TREX is recruited co-transcriptionally; in human cells it is recruited during a late step of splicing.
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Certain images such as the China Poblana, rural scenes, charros etc.,began to appear almost ubiquitously on products artisans were making. The promotion of Mexican artesanía was accepted earlier by foreigners than by Mexicans themselves. Very few examples of crafts from the early 20th century survive and most of the best collections of it are in North American or European hands. Native Mexican appreciation of their own crafts would be helped near the mid century, in part because of the popularity of films by Emilio “El Indio” Fernández and Gabriel Figueroa. Eventually, even homes in the exclusive Lomas de Chapultepec neighborhood of Mexico City would have some touch of “lo mexicano” (Mexican-ness) in their décor.
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CCDC130 is a ubiquitously expressed protein, showing some expression level in all tissue and cell samples analyzed. The AceView profile for CCDC130 shows expression levels 2.9 times higher than the average protein. The level of expression varies greatly between tissues, but there is at least some level of expression in every sample. According to NCBI GEO profiles and BioGPS data, the fetal thyroid, adrenal cortex, uterus, prostate, testes, seminiferous tubule, heart, PB-CD4+ T cells, PB-CD8+ T cells, lymph node, lung, thymus, thyroid, leukemia chronic myelogenous K562, and leukemia lymphoblastic molt4 samples all had at expression levels above the 75th percentile for gene expression in at least one of two samples.
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Sortilin (SORT1) is a protein that in humans is encoded by the SORT1 gene on chromosome 1. This protein is a type I membrane glycoprotein in the vacuolar protein sorting 10 protein (Vps10p) family of sorting receptors. While it is ubiquitously expressed in many tissues, sortilin is most abundant in the central nervous system. At the cellular level, sortilin functions in protein transport between the Golgi apparatus, endosome, lysosome, and plasma membrane, leading to its involvement in multiple biological processes such as glucose and lipid metabolism as well as neural development and cell death. Moreover, the function and role of sortilin is now emerging in several major human diseases such as atherosclerosis and coronary artery disease, Alzheimer’s disease, and cancer.
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The term colloquial language does explicitly not mean the many local languages, which in Germany commonly are referred to as "dialects", even if they still dominate everydays communication here and there. It rather means a common regional colloquial language, also termed a Regiolect, which has developed very recently as a kind of dachsprache enveloping the older local languages. It is more or less influenced by the so- called dialects, but in itself a variant of Standard German or High German, which incorporates several mild, globalized and unified localisms. It does have subregional variations itself, but these are less, and almost always ubiquitously comprehended, as opposed to the local languages, which are far more diverse, and most often largely mutually incomprehensible, when geographically somewhat distant.
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Dempster is widely known for his laid-back attitude, constantly joking with fans and teammates, and is said to be a positive contribution to a team's clubhouse. Dempster's fun and easy-going personality was especially evident when, in comments to an Arizona newspaper in March 2007, Dempster stated that if his career as a closer began to tumble, he would pursue ninja training. In early June 2009, Dempster released a statement explaining that his daughter, Riley Dempster, had DiGeorge Syndrome, also known as Velo-cardio-facial syndrome (VCFS), 22q11.2 deletion syndrome, and Shprintzen syndrome (after Dr. Robert Shprintzen who identified it in 1978). About 1 baby in 1800 is born with this genetic deletion which ubiquitously affects swallowing, breathing, and speech.
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Acanthamoeba keratitis is a rare disease in which amoebae of the genus Acanthamoeba invade the clear portion of the front (cornea) of the eye, and affects roughly 100 people in the United States each year. Acanthamoeba are protozoa found nearly ubiquitously in soil and water, and can cause infections of the skin, eyes, and central nervous system. Infection of the cornea by Acanthamoeba is difficult to treat with conventional medications, and Acanthamoeba keratitis (AK) may cause permanent visual impairment or blindness, due to damage to the cornea or through damage to other structures important to vision. Recently, AK has been recognized as an orphan disease and a funded project, orphan diseases Acanthamoeba keratitis (ODAK), has tested the effects of a diverse range drugs and biocides on AK.
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Seafood is generally not consumed in large amounts, though it is very popular in the coastal areas of Sindh and the Makran coast of Balochistan and was a dominant element of the cuisine of the former East Pakistan (now Bangladesh). Curries, with or without meat, combined with local vegetables, such as bitter gourd, cauliflower, eggplant, okra, cabbage, potatoes, rutabaga, saag, and chili peppers are most common and cooked for everyday consumption. A typical example is aloo gosht (literally "potatoes and meat"), a homestyle recipe consisting of a spiced meat and potato stew, and is ubiquitously prepared in many households. Korma is a classic dish of Mughlai origin made of either chicken or mutton, typically eaten with naan or other bread, and is very popular in Pakistan.
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The SH3 domain is a point of contact with polyproline sequences on focal adhesion kinase (FAK). or the related kinase PTK2B, also known as RAFTK/Pyk2/CAKβ. Typically, phosphorylation of the C-terminal region of CAS proteins by FAK or PTK2B creates a binding site for the SH2 domain of a SRC-family protein, which then hyper-phosphorylates the substrate domain, allowing the CAS protein to function as a scaffold for other proteins including CRK proteins and C3G, a guanine nucleotide exchange factor (GEF) for RAP1. PTP-PEST, a soluble protein tyrosine phosphatase that is ubiquitously expressed in mice both during embryonic development and in adult tissues, opposes FAK and PTK2B activity, as it dephosphorylates PTK2B, FAK and CAS family members, among other proteins.
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ATP) than complete oxidation through respiration, and yet overflow metabolism - known as the Warburg effect in the context of cancer \- occurs ubiquitously among fast-growing cells, including bacteria, fungi and mammalian cells. Based on experimental studies of acetate overflow in Escherichia coli, recent research has offered a general explanation for the association of overflow metabolism with fast growth. According to this theory, the enzymes required for respiration are more costly than those required for partial oxidation of glucose. That is, if the cell were to produce enough of these enzymes to support fast growth with respiratory metabolism, it would consume much more energy, carbon and nitrogen (per unit time) than supporting fast growth with an incompletely oxidative metabolism (e.g. fermentation).
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It is likely that some level of adaptation occurred after the loss of the GULO gene by primates. Erythrocyte Glut1 and associated dehydroascorbic acid uptake modulated by stomatin switch are unique traits of humans and the few other mammals that have lost the ability to synthesize ascorbic acid from glucose. As GLUT transporters and stomatin are ubiquitously distributed in different human cell types and tissues, similar interactions can be hypothesized to occur in human cells other than erythrocytes. Pauling observed that after the loss of endogenous ascorbate production, apo(a) and Lp(a) were greatly favored by evolution, acting as ascorbate surrogate, since the frequency of occurrence of elevated Lp(a) plasma levels in species that had lost the ability to synthesize ascorbate is great.
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Popular examples include Promoted Tweets on Twitter, Sponsored Stories on Facebook, and TrueView Video Ads on YouTube. Open platforms are defined by the promotion of the same piece of branded content across multiple platforms ubiquitously, but through some variation of native ad formats. Unlike closed platforms, the content itself lives outside any given website that it appears on, and is usually distributed across multiple sites by a third party company, meaning that the advertisements appearing on open platforms namely are placed there by an advertiser. Hybrid platforms allow the content publishing platforms to install a private marketplace where advertisers have the option to bid on the inventory of ad space either through direct sales or programmatic auction through what is known as Real-Time Bidding (RTB).
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The lethal yellow (Ay) mutation is due to an upstream deletion at the start site of agouti transcription. This deletion causes the genomic sequence of agouti to be lost, except the promoter and the first non-encoding exon of Raly, a ubiquitously expressed gene in mammals. The coding exons of agouti are placed under the control of the Raly promoter, initiating ubiquitous expression of agouti, increasing production of pheomelanin over eumelanin and resulting in the development of a yellow phenotype.Proposed mechanism for the relationship between ectopic agouti expression and the development of yellow obese syndrome The viable yellow (Avy) mutation is due to a change in the mRNA length of agouti, as the expressed gene becomes longer than the normal gene length of agouti.
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Given that the New York City metropolitan area has become home to the largest overseas Chinese population outside of Asia, all popular styles of regional Chinese cuisine have commensurately become ubiquitously accessible in New York City, including Hakka, Taiwanese, Shanghainese, Hunanese, Szechuan, Cantonese, Fujianese, Xinjiang, Zhejiang, Korean-Chinese, and Malaysian Chinese cuisine. Even the relatively obscure Dongbei style of cuisine indigenous to Northeast China is now available in Flushing, Queens, as well as Mongolian cuisine and Uyghur cuisine. The availability of the regional variations of Chinese cuisine originating from throughout the different Provinces of China is most apparent in the city's Chinatowns in Queens, particularly the Flushing Chinatown (法拉盛華埠), but is also notable in the city's Chinatowns in Brooklyn and Manhattan.
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Maurer's classification of Germanic dialects Maurer asserted that the cladistic tree model, ubiquitously used in 19th and early 20th century linguistics, was too inaccurate to describe the relation between the modern Germanic languages, especially those belonging to its Western branch. Rather than depicting Old English, Old Dutch, Old Saxon, Old Frisian and Old High German to have simply 'branched off' a single common 'Proto-West Germanic', he proposed that there had been much more distance between the languages and the dialects of the Germanic regions.Johannes Hoops, Heinrich Beck, Dieter Geuenich, Heiko Steuer: Reallexikon der germanischen Altertumskunde: Band 7; Walter de Gruyter, 1989, (pp 113–114). Weser-Rhine Germanic seems to have been transitional between Elbe Germanic and North Sea Germanic, with a few innovations of their own.
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There is often little obvious difference (particularly when only fragments survive) between Roman bricks used for walls on the one hand, and tiles used for roofing or flooring on the other, so archaeologists sometimes prefer to employ the generic term ceramic building material (or CBM). St. George Rotunda (4th century) and remains of Serdica, Sofia, Bulgaria The Romans perfected brick-making during the first century of their empire and used it ubiquitously, in public and private construction alike. The Romans took their brickmaking skills everywhere they went, introducing the craft to the local populations. The Roman legions, which operated their own kilns, introduced bricks to many parts of the empire; bricks are often stamped with the mark of the legion that supervised their production.
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In fact, there is evidence that VDAC binding by the anti-apoptotic HK1 and by the pro-apoptotic creatine kinase are mutually exclusive, indicating that the absence of HK1 allows creatine kinase to bind and open VDAC. Furthermore, HK1 has demonstrated anti-apoptotic activity by antagonizing Bcl-2 proteins located at the OMM, which then inhibits TNF- induced apoptosis. In the prefrontal cortex, HK1 putatively forms a protein complex with EAAT2, Na+/K+ ATPase, and aconitase, which functions to remove glutamate from the perisynaptic space and maintain low basal levels in the synaptic cleft. In particular, HK1 is the most ubiquitously expressed isoform out of the four hexokinases, and constitutively expressed in most tissues, though it is majorly found in brain, kidney, and red blood cells (RBCs).
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It is reasonable to infer that prior to Siegling's occupancy, all of Roper House's windows were the 6 part sash used ubiquitously in 1838. On August 31, 1886, during Siegling's tenure at Roper House, Charleston was struck by a powerful earthquake resulting in sixty deaths, and tremendous damage to the city's structures. Next door, the portico of William Ravenel's house collapsed, but Roper House suffered minor damage — the east and north facades cracked, requiring patching and anchorage, but the monumental portico escaped unscathed; the Charleston city engineer pronounced it to be in "good" condition. In the years after the earthquake, Siegling demolished the old carriage house, and replaced it with a rear wing to the main house, faithfully reproducing Roper House's neoclassical bracketed cornice and balustrade.
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The well received project has seen more than a million combined streams and downloads via the online mixtape site DatPiff. Monster standout "Commas" was released as an official commercial single in March 2015 and spent 20 weeks on the Billboard Hot 100 chart, peaking at number 55, simultaneity earning an RIAA gold certification further cementing Southside's career boost. In 2015, Southside continued to push his trap sound in the hip hop industry ubiquitously, especially on various songs produced by him and his 808 Mafia collective. Luellen was responsible for producing a significant portion of Future's album, DS2, as well as being responsible for producing nine of the ten tracks of Future's mixtape, 56 Nights, in which Southside made the entire project's worth of beats in only one night.
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TMEM63 is ubiquitously expressed throughout the human body at varying levels, occurring with the highest relative prevalence in CD 8+ T cells and CD 4+ T cells. Moderate relative levels of expression are also observed throughout the brain, particularly in the occipital lobe, parietal lobe, and pancreas. Analysis of TMEM63A expression in the mouse using BioGPS revealed more variable expression patterns, with the highest expression being seen in the stomach and large intestine. Using the El Dorado program from Genomatix, transcription factor regulation was predicted, which found that ‘’TMEM63A’’ is highly regulated by E2F cell cycle regulators and EGR1, a factor believed to be a tumor suppressor gene with expression in the brain. The 3’ UTR is predicted to be bound by the regulatory element miR-9/9ab.
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George and Barbara Bush, 2001 His eldest son, George W. Bush, was inaugurated as the 43rd president of the United States on January 20, 2001, and re-elected in 2004. Through previous administrations, the elder Bush had ubiquitously been known as "George Bush" or "President Bush", but following his son's election the need to distinguish between them has made retronymic forms such as "George H. W. Bush" and "George Bush Sr." and colloquialisms such as "Bush 41" and "Bush the Elder" became much more common. H.W. Bush was traveling to Minnesota for a speaking engagement on the day of the September 11 attacks. George W. made multiple calls to get in contact with his father before the two men reconnected after the elder Bush had gone to a Brookfield, Wisconsin motel.
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Lance left Utah (having completed his PhD course work and exams except the writing of a thesis) in 1977 to join the New York Institute of Technology (NYIT). While at NYIT, Williams invented the mipmapping technique for texture filtering, which is ubiquitously used today by graphics hardware for PCs and video games, and wrote and directed the abandoned project The Works which would have been the first entirely 3D CGI film had it been finished in the early 1980s as intended. Williams was awarded his PhD in 2000 from the University of Utah based on a rule allowing someone who published three seminal papers in his field to bind them together as his thesis. The three papers are Casting Curved Shadows on Curved Surfaces (1978), Pyramidal Parametrics (1983) and View Interpolation for Image Synthesis (1993).
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4-OH-E2 shares the metabolic scheme of 2-OH-E2: methylation to 4-methoxyestradiol (4-meOE2), oxidation to quinones, or dehydrogenation to 4-OH-E1. Conjugation by the ubiquitously present COMT represents the most common extrahepatic pathway of 4-OH-E2 inactivation. However, if estrogen homeostasis is imbalanced by an increase in CYP1B1 and a decrease in COMT, a greater degree of genotoxic quinone formation from 4-OH-E2 will occur. 4-OHE2 can be oxidized by microsomal CYPs or peroxidases to yield estradiol-3,4-semiquinone. This semiquinone can undergo redox cycling with oxygen to form estradiol-3,4-quinone (E2-3,4-Q) and superoxide. E2-3,4-Q can be converted back to 4-OHE2 in a single step by quinone reductase, or in two sequential steps catalysed by P450 reductase via the semiquinone intermediate.
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Romans who competed in the Olympic Games presumably followed the Greek custom of nudity, but athletic nudity at Rome has been dated variously, possibly as early as the introduction of Greek-style games in the 2nd century BC but perhaps not regularly until the time of Nero around 60 AD. At the same time, the phallus was depicted ubiquitously. The phallic amulet known as the fascinum (from which the English word "fascinate" ultimately derives) was supposed to have powers to ward off the evil eye and other malevolent supernatural forces. It appears frequently in the archaeological remains of Pompeii in the form of tintinnabula (wind chimes) and other objects such as lamps. The phallus is also the defining characteristic of the imported Greek god Priapus, whose statue was used as a "scarecrow" in gardens.
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Linux is ubiquitously found on various types of hardware. The Linux kernel is a widely ported operating system kernel, available for devices ranging from mobile phones to supercomputers; it runs on a highly diverse range of computer architectures, including the hand-held ARM- based iPAQ and the IBM mainframes System z9 or System z10. Specialized distributions and kernel forks exist for less mainstream architectures; for example, the ELKS kernel fork can run on Intel 8086 or Intel 80286 16-bit microprocessors, while the µClinux kernel fork may run on systems without a memory management unit. The kernel also runs on architectures that were only ever intended to use a manufacturer-created operating system, such as Macintosh computers (with both PowerPC and Intel processors), PDAs, video game consoles, portable music players, and mobile phones.
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Connexin 43 distribution in the rat myocardium (gap junctions between cardiomyocytes) As a member of the connexin family, GJA1 is a component of gap junctions, which are intercellular channels that connect adjacent cells to permit the exchange of low molecular weight molecules, such as small ions and secondary messengers, to maintain homeostasis. GJA1 is the most ubiquitously expressed connexin and is detected in most cell types. It is the major protein in heart gap junctions and is purported to play a crucial role in the synchronized contraction of the heart. Despite its key role in the heart and other vital organs, GJA1 has a short half-life (only two to four hours), indicating that the protein undergoes daily turnover in the heart and may be highly abundant or compensated with other connexins.
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Typical Southwest circulation, east of the Rockies, of a Colorado low. For a Panhandle hook, the flow should be slightly further east. A panhandle hook storm has its origins as a strong shortwave low pressure system which traverses the base of a long- wave low pressure trough while geographically coincident with the southwestern United States. Such systems ubiquitously develop a surface low-pressure system in the northwestern Texas and western Oklahoma area (as an eddy effect interaction of the topography of the Rocky Mountains in relation to the jet stream) with associated warm front and cold front, with attending snow to the northwest of the low and severe thunderstorms to the southeast -- the "hook" refers to the left-ward east to northeast jog in the track of the surface low as it is plotted on a weather analysis chart.
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Over the years, ORA has advocated and won additional protections for wireless telephone customers as the CPUC adopted rules in requiring phone companies to be responsible for the content of their bills, refund customers for unauthorized charges, and provide customers with the option to block third party charges to their phone bills. The California High Cost Fund-A (CHCF-A) is a CPUC subsidy program established in 1987 based on the concept that basic telephone service should be affordable and ubiquitously accessible to all members of society. In order to optimally utilize ratepayer subsidies, ORA supports CHCF-A improvements that will result in program and rate case processing efficiencies. Beginning 2016, ORA will be actively working to provide evidence and in-depth analysis to shape a robust record in the CPUC's investigation to assess the state of the telecommunications market in California.
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The development of QTAIM was driven by the assumption that, since the concepts of atoms and bonds have been and continue to be so ubiquitously useful in interpreting, classifying, predicting and communicating chemistry, they should have a well-defined physical basis. QTAIM recovers the central operational concepts of the molecular structure hypothesis, that of a functional grouping of atoms with an additive and characteristic set of properties, together with a definition of the bonds that link the atoms and impart the structure. QTAIM defines chemical bonding and structure of a chemical system based on the topology of the electron density. In addition to bonding, AIM allows the calculation of certain physical properties on a per- atom basis, by dividing space up into atomic volumes containing exactly one nucleus, which acts as a local attractor of the electron density.
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Funerary Monument to Sir John Hawkwood: the figure is larger than life-size, central panel (1436), measures 732 × 404 cm (288 × 159 in); with Trompe-l'œil grotto-esque frame added in 1524, 820 × 515 cm (323 × 203 in). Fresco of Sir John Hawkwood (right) shown in situ in the Duomo, Florence, beside a similar depiction of fellow condottiero Niccolò da Tolentino (d.1435) by Andrea del Castagno The Funerary Monument (or Equestrian Monument) to Sir John HawkwoodAlthough the title of "Sir" is ubiquitously attached to Hawkwood, there is no documentary evidence of the circumstances under which Hawkwood was knighted; most of his contemporary condottieri, regardless of their reputations, were also knights. Hawkwood's knighthood is not listed in the "Register" of Edward, the Black Prince, and some proponents of his knighthood claim that it occurred in Italy.
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The industry is fragmented and extends from small, privately owned companies to divisions of big, diversified chemical enterprises. The term "fine chemicals" is used in distinction to "heavy chemicals", which are produced and handled in large lots and are often in a crude state. Since their inception in the late 1970s, fine chemicals have become an important part of the chemical industry. The total production value of $85 billion is split about 60 / 40 among in- house production by the main consumers, the life science industry, on the one hand, and the fine chemicals industry on the other hand. The latter pursues both a “supply push” strategy, whereby standard products are developed in- house and offered ubiquitously, and a “demand pull” strategy, whereby products or services determined by the customer are provided exclusively on a “one customer / one supplier” basis.
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1880, L'Homme au balcon (Man on a Balcony), oil on canvas, 116 x 97 cm, private collection After the completion of both this work and the publication of Du "Cubisme", Gleizes became convinced that artists could explain themselves as well as or better than critics. He wrote and granted interviews during the following years when Du "Cubisme" was enjoying wide circulation and considerable success.Daniel Robbins, MoMA, From Grove Art Online, Oxford University Press, 2009 While still 'readable' in the figurative or representational sense, Man on a Balcony demonstrates the mobile, dynamic fragmentation of form characteristic of Cubism at the artistic movements peak of 1912. Highly sophisticated both physically and in theory, this aspect of visualizing objects from several successive viewpoints called multiple perspective—different from illusion of motion associated with Futurism—would soon become ubiquitously identified with the practices of the Groupe de Puteaux.
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The song won Medley and Warnes a 1988 Grammy Award for Best Pop Performance by a Duo or Group with Vocal and an Academy Award for Best Original Song for the composers. "(I've Had) The Time of My Life" is now seen and heard ubiquitously on TV and radio commercials—covered by singers other than Medley and Warnes—usually connected with vacation, cruise, resort, and other such holiday-themed advertisers. Among his other notable songs are "Most of All You", the closing theme to the movie Major League; "Friday Night's A Great Night For Football" from Tony Scott's movie, The Last Boy Scout; and the theme song for the Growing Pains spinoff, Just The Ten of Us. He also collaborated with Giorgio Moroder and scored a moderate UK hit in 1988 with a version of "He Ain't Heavy, He's My Brother". Medley recorded a video for the song which was also used as the end credit theme for Rambo III.
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While there is much disparity between the two texts, they do agree on at least one issue: In both the Record and Kyotaku Denki the notion of Puhua being an eccentric imbued with a sort of crazy wisdom, and perhaps even an iconoclast, is supported. Yet the texts again diverge on the issue of Fuke's influence on the Fuke sect of Japan: While the Kyotaku Denki directly attributes the founding of the school to him, the Fuke sect did not exist in China and as such he is never mentioned to be the leader of a separate religious tradition in the Linji lu. Although this is the case, the Record does provide certain subtleties regarding Puhua as being a person of his own, self-directed character who often did things ubiquitously and ignored social norms and doctrinal establishments. The following account of Puhua's life is an amalgamation of the accounts featured in both the Record and Kyotaku Denki, although it includes some outside references as well.
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Among interpreters who see the film reflecting more subtly the social concerns that animate other Kubrick films, one of the earliest viewpoints was discussed in an essay by ABC reporter Bill Blakemore entitled "Kubrick's 'Shining' Secret: Film's Hidden Horror Is The Murder Of The Indian", first published in The Washington Post on July 12, 1987.Blakemore's essay has gone on to be discussed in several books on Kubrick particularly Julien Rice's Kubrick's Hope as well as a study of Stephen King films Stephen King on the Big Screen by Mark Browning. It is also assigned in many college film courses, and discussed ubiquitously on the InternetBlakemore is best known as a spearhead for global warming issues and having been ABC News' Vatican Correspondent since 1970. He believes that indirect references to American killings of Native Americans pervade the film, as exemplified by the Amerindian logos on the baking powder in the kitchen and the Amerindian artwork that appears throughout the hotel, though no Native Americans are seen.
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Expression levels of CXorf26 in common human tissues, as referenced in GEO profiles from NCBI Expression data for CXorf26 shows it is highly ubiquitously expressed throughout human tissues and ESTs in nearly all situations. The GEO profile to the right shows the expression levels for CXorf26 in common human tissues to consistently be around the 75th percentile range, suggesting it may possess a housekeeping function due its seemingly ubiquitous expression. If the conserved domain does indeed play a role in polysaccharide biosynthesis of some sort, this high gene expression is sensible to that function. CXorf26 expression goes down greatly when CLDN1 is overexpressed, suggesting a relationship between CXorf26 and the cell surface, as predicted by its polysaccharide biosynthesis domain Gene expression profiles in the Gene Expression Omnibus (GEO) repository located within the NCBI website demonstrated that there were not many treatments that resulted in a changing of expression of CXorf26 in examined tissues.
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LRP1 is a member of the LDLR family and ubiquitously expressed in multiple tissues, though it is most abundant in vascular smooth muscle cells (SMCs), hepatocytes, and neurons. LRP1 plays a key role in intracellular signaling and endocytosis, which thus implicate it in many cellular and biological processes, including lipid and lipoprotein metabolism, protease degradation, platelet derived growth factor receptor regulation, integrin maturation and recycling, regulation of vascular tone, regulation of blood brain barrier permeability, cell growth, cell migration, inflammation, and apoptosis, as well as diseases such as neurodegenerative diseases, atherosclerosis, and cancer. To elaborate, LRP1 mainly contributes to regulate protein activity by binding target proteins as a co-receptor, in conjunction with integral membrane proteins or adaptor proteins like uPA, to the lysosome for degradation. In lipoprotein metabolism, the interaction between LRP1 and APOE stimulates a signaling pathway that leads to elevated intracellular cAMP levels, increased protein kinase A activity, inhibited SMC migration, and ultimately, protection against vascular disease.
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This battle figures in La otra muerte, a short story by Argentine writer Jorge Luis Borges, in his collection El Aleph. The story concerns a certain Pedro Damián, whose personal history initially appears to have been one of a coward who fled the cannon fire at the Battle of Masoller, to survive as a virtual hermit until his death nearly forty years later. During the course of the story, however, the narrator finds that this same history has somehow spontaneously converted into the tale of a hero who died at the head of the charge in the same Battle of Masoller in 1904: the underlying idea of Borges is that personal and historical memory is complex. La otra muerte addresses the relationship between the present and history and the question of how a single event can change, or be perceived to change, an infinite number of destinies, Characteristically, Borges chose for this story a military event ubiquitously interpreted as determining the course of twentieth-century Uruguay.
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Bacterial species that lack the non-mevalonate pathway and synthesize IPP via the classical mevalonate pathway instead, such as Streptococcus, Staphylococcus, and Borrelia, are unable to produce HMB-PP and do not specifically activate Vγ9/Vδ2 T cells. IPP itself is structurally closely related to HMB-PP and ubiquitously present in all living cells (including human cells), yet its potency in vitro is reduced 10,000-fold; whether IPP represents a physiological 'danger' signal of stressed or transformed cells is still unclear. Of pharmacological interest and with bioactivities comparable to that of IPP are synthetic aminobisphosphonates such as zoledronate (Zometa) or pamidronate (Aredia), that are widely used to treat osteoporosis and bone metastases, and incidentally act as Vγ9/Vδ2 T cell receptor agonists. However, increasing evidence suggests that these aminobisphosphonate 'antigens' are not recognised directly by Vγ9/Vδ2 T cells and in fact act indirectly, via their effects on the mevalonate biosynthetic pathway, leading to an accumulation of IPP.
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A Red Ball Express truck gets stuck in the mud during World War II - 1944 1971 AM General M35A2 with winch and camouflage cargo cover The -ton, 6×6 truck was a standard class of medium duty trucks, designed during the beginning of World War II for the US Armed Forces, in service for over half a century, from 1940 into the 1990s. Also frequently known as the deuce and a half, or just deuce, this nickname was popularized post WW II, likely in the Vietnam war era.The American Automobile Industry in World War Two (2-1-2019) The basic cargo versions were designed to transport a cargo load of nominally over all terrain, in all weather. The -ton trucks were used ubiquitously in World War II, and continued to be the U.S. standard medium duty truck class after the war, including wide usage in the Korean and Vietnam Wars, as well as the first Gulf War.
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Mestiço man with gun and sword under a fruiting papaya tree, Albert Eckhout, mid-seventeenth century Dutch Brazil Mestiço, in Colonial Brazil, was initially used to refer to , persons born from a couple in which one was an Indigenous American and the other a European. It literally translates as "mameluke", probably referring to the common Iberian comparisons of swarthy people to North Africans (cf. , "tawny, swarthy, tanned" but also "dark colored" or "dark-haired human", from , "Moor"). The term fell in disuse in Brazil and was replaced by the much more familiar-sounding (formerly , from Tupi ka'abok, "the ones coming from the wilderness") or (from kari'boka, "what comes from the white man"; could also mean the child of a and a white person, equivalent to the Spanish , or to the child of a and an Indigenous person, equivalent to the Spanish ), given the fact that most Brazilians, even those living in ubiquitously Christian villages and towns, spoke Tupi and the Tupi- derived until the 18th century, when they were banned by the Marquis of Pombal in 1777.
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From the 1950s through the 1970s the holster type was popular with American law enforcement due to the high level of security provided to the revolver used ubiquitously during the period. Because the Berns-Martin split-front holsters can only be used with revolvers (the rear loop of the trigger guard being engaged to grasp the revolver), and the near universal adoption of semi-automatic pistols by American law enforcement in the 1980s, the split-front revolver holster has fallen out of favor with American police forces since the 1980s. A second, and equally well-known version, of the Berns-Martin holster was the company's holster, a shoulder holster also for revolvers that carried them with the muzzles pointed upwards; that is, "upside down". It was this holster that was made famous by its inclusion in Ian Fleming's later Bond books, although it was not suited to Bond's Walther semi-auto pistol, causing the company to mark its brochures of the period, "no shoulder holster made for automatics".
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Nevertheless, the partisan struggle, found at the same time as an attraction and as a punishment, is present ubiquitously throughout the whole book; the reason is that "politics forced their way into the Spanish families on the 20th century being cleaved just like an icebreaker". The relatives he speaks about are: his father, Leopoldo Calvo Sotelo, independent monarchical, his liberal grandfather Ramón Sotelo, his conservative uncle José Calvo Sotelo, his great uncle Adolfo Vázquez, founder of the first Masonic lodge in Uruguay, his uncles Francisco Bustelo, an engineer, and Joaquín Calvo Sotelo, playwright, his father-in-law José Ibáñez Martín, ministry during Franco’s government and his brother-in-law Fernando Morán, a socialist politician. Leopoldo Calvo-Sotelo also describes his relationship with figures of the Spanish political scene such as Juan de Borbón, Federico Silva, Alfonso Osorio and Gonzalo Fernández de la Mora. To write about it, Leopoldo Calvo-Sotelo consulted several files and researched in the National Library of Spain, as explained by Paloma Fernández Palomeque, who had been his librarian and archivist, and as explained by the author himself.
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It is a situation similar to lipocalins (from Greek lipos=fat and Greek kalyx=cup), where the name designates a superfamily of widely distributed and heterogenous proteins, which transport small hydrophobic molecules including steroids and lipids. However, in contrast to lipocalins, the “CSP” family refers to homogenous evolutionary-well conserved proteins with characteristic sequence (4 cysteines), tissue profiling (ubiquitously expressed), and rather highly diverse binding properties (not only to long fatty acids (FAs) and straight lipid chains, but also to cyclic compounds such as cinnamaldehyde) [34]. Therefore, it is rather difficult to name groups and sub-groups within the CSP family, although numerous CSP proteins are mainly produced in the gut and the fat body that are considered as the insect body’s principle storage organs for energy in the forms of FAs and lipids, which are mobilized through lipolysis process to provide fuel to other organs to develop, regenerate or grow and/or to respond to an infectious agent [4, 14, 50]. In moths, specific lipid chains are mobilized for pheromone synthesis [9-14].
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By beginning of the 1990s the school had managed to certify their students with English as a second language providing Cambridge certification, provide an ubiquitously environmental education and to be the first school in Acapulco with a computerized multimedia hall. In the year of 1995 the school made an agreement with Lions Clubs International to buy their facilities and transform it from a social club into a school campus. The school has maintained the leadership in each of this matters, specially that of technological culture, being the first school in Acapulco in obtaining the service that allows the parents of our lower school students to see their children work in the classroom via Internet and being again the first school in Acapulco to have a technological partnership with Apple Inc. In 2008 the school designed new architectonic facilities to provide the students with the latest technological advances that go from interactive blackboards to promoting the use of laptops or iPad amongst the students instead of the traditional books and notebooks.
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The New York metropolitan area is home to Chinese populations representing the largest Chinese population outside of Asia, constituting the largest metropolitan Asian American group in the United States, and the largest Asian-national metropolitan diaspora in the Western Hemisphere. The Chinese American population of the New York City metropolitan area was an estimated 893,697 as of 2017; and given the New York metropolitan area's status as the leading gateway for Chinese immigrants to the United States, greater than San Francisco and Los Angeles combined, all popular styles of regional Chinese cuisine have commensurately become ubiquitously accessible in New York City, including Hakka, Taiwanese, Shanghainese, Hunanese, Szechuan, Cantonese, Fujianese, Xinjiang, Zhejiang, and Korean Chinese cuisine. Even the relatively obscure Dongbei style of cuisine indigenous to Northeast China is now available in Flushing, Queens, as well as Mongolian cuisine and Uyghur cuisine. The availability of the regional variations of Chinese cuisine originating from throughout the different provinces of China is most apparent in the city's Chinatowns in Queens, particularly the Flushing Chinatown (法拉盛華埠), but is also notable in the city's Chinatowns in Brooklyn and Manhattan.
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From the introduction of the IBM Personal Computer (ubiquitously known as the PC) in 1981, the market for computers meant for the corporate, business, and government sectors came to be dominated by the new machine and its MS-DOS operating system. Even basic PCs cost thousands of dollars and were far out of reach for typical home computerists. However, in the following years technological advances and improved manufacturing capabilities (mainly greater use of robotics and relocation of production plants to lower-wage locations in Asia) permitted several computer companies to offer lower-cost PC style machines that would become competitive with many 8-bit home-market pioneers like Radio Shack, Commodore, Atari, Texas Instruments, and Sinclair. PCs could never become as affordable as these because the same price-reducing measures were available to all computer makers. Furthermore, software and peripherals for PC style computers tended to cost more than those for 8-bit computers because of the anchoring effect caused by the pricey IBM PC. As well, PCs were inherently more expensive since they could not use the home TV set as a video display.
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