The launch of the Cloud Native Foundation (CNF) last July caused a few stirs because it brought together a very wide range of companies, including AT&T, Box, Cisco, CoreOS, Docker, Google, IBM, Intel, Red Hat, Twitter and VMware.
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Terry believes that Conversica has a clear edge over these, not just because of the revenues it is making and their growth, but because of the size of its customer base — it works with some 1,000 large enterprises including AT&T, Box, Chrysler, Snowflake Computing, CenturyLink, the Sacramento Kings, Oracle, and SAP — and that has afforded it a huge trove of data to "teach" its system to work better.
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T-box transcription factor TBX21, also called T-bet (T-box expressed in T cells) is a protein that in humans is encoded by the TBX21 gene.
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T-box transcription factor TBX3 is a protein that in humans is encoded by the TBX3 gene. T-box 3 (TBX3) is a member of the T-box gene family of transcription factors which all share a highly conserved DNA binding domain known as the T-box. The T-box gene family consists of 17 members in mouse and humans that are grouped into five subfamilies, namely Brachyury (T), T-brain (Tbr1), TBX1, TBX2, and TBX6. Tbx3 is a member of the Tbx2 subfamily which includes Tbx2, Tbx4 and Tbx5.
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T-box transcription factor TBX5 is a protein that in humans is encoded by the TBX5 gene. This gene is a member of a phylogenetically conserved family of genes that share a common DNA-binding domain, the T-box. T-box genes encode transcription factors involved in the regulation of developmental processes. This gene is closely linked to related family member T-box 3 (ulnar mammary syndrome) on human chromosome 12.
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The second tRNA binding sequence, the T box sequence, is complementary to the nucleotide preceding the acceptor end of the tRNA. The T box is found in the side bulge of the antiterminator.
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Eomesodermin also known as T-box brain protein 2 (Tbr2) is a protein that in humans is encoded by the EOMES gene. A representation of the T box DNA binding domain The Eomesodermin/Tbr2 gene, EOMES, encodes a member of a conserved protein family that shares a common DNA-binding domain, the T-box. T-box genes encode transcription factors, which control gene expression, involved in the regulation of developmental processes. Eomesodermin/Tbr2 itself controls regulation of radial glia, as well as other related cells.
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T-box transcription factor TBX19 is a protein that in humans is encoded by the TBX19 gene. This gene is a member of a phylogenetically conserved family of genes that share a common DNA-binding domain, the T-box. T-box genes encode transcription factors involved in the regulation of developmental processes. This gene is the human ortholog of mouse Tbx19/Tpit gene.
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T-box refers to a group of transcription factors involved in embryonic limb and heart development. Every T-box protein has a relatively large DNA-binding domain, generally comprising about a third of the entire protein that is both necessary and sufficient for sequence-specific DNA binding. All members of the T-box gene family bind to the "T-box", a DNA consensus sequence of TCACACCT. Mutations in the first one found caused short tails in mice, and thus the protein encoded was named brachyury, Greek for "short-tail".
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Telstra released "T-Box" in mid-2010, initially to Melbourne Bigpond cable customers. T-Box is a digital set-top box and personal video recorder with access to free-to-air TV channels and an ability to rent movies and TV episodes using Telstra home broadband. It can also access BigPond Internet TV channels and Telstra TV Box Office, as well as apps like YouTube. The T-Box is no longer available for sale, being replaced with Telstra TV;Telstra T-Box but existing T-Boxes continue to be functional.
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The most common model system used to study T-box leader is in the gram-positive bacterium Bacillus subtilis. In terms of what is currently understood about the regulatory role of T box function, it appears that when the uncharged tRNA is abundant, it binds to the specifier and the T box sequence of an appropriate leader RNA, stabilizing the antiterminator and, in turn, preventing terminator formation. Without terminator formation, transcription will proceed. If, however, the tRNA is charged, its acceptor end will be blocked by an amino acid and thus, cannot pair with the T box.
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T-box 6 is a protein that in humans is encoded by the TBX6 gene.
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T box proteins and the polycomb group have been shown to repress p16INK4a, p15INK4b, and ARF.
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T-box transcription factor TBX22 is a protein that in humans is encoded by the TBX22 gene. TBX22 is a member of a phylogenetically conserved family of proteins that share a common DNA-binding domain, the T-box. T-box genes encode transcription factors involved in the regulation of developmental processes. Mutations in this gene have been associated with the inherited X-linked disorder, cleft palate with ankyloglossia (tongue-tie), and it is believed to play a major role in human palatogenesis.
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It is assumed that the mouse nomenclature will also be updated in due course. The mouse T gene was cloned by Bernhard Herrmann and colleagues and proved to encode a 436 amino acid embryonic nuclear transcription factor. T binds to a specific DNA element, a near palindromic sequence TCACACCT through a region in its N-terminus, called the T-box. T is the founding member of the T-box family which in mammals currently consists of 18 T-box genes.
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Usually found in gram-positive bacteria, the T box leader sequence is an RNA element that controls gene expression through the regulation of translation by binding directly to a specific tRNA and sensing its aminoacylation state. This interaction controls expression of downstream aminoacyl-tRNA synthetase genes, amino acid biosynthesis, and uptake-related genes in a negative feedback loop. The uncharged tRNA acts as the effector for transcription antitermination of genes in the T-box leader family. The anticodon of a specific tRNA base pairs to a specifier sequence within the T-box motif, and the NCCA acceptor tail of the tRNA base pairs to a conserved bulge in the T-box antiterminator hairpin.
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Abnormal expression of several T-box genes has been shown to cause developmental anomalies in mouse, Drosophila or zebrafish.
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Brachyury (from Greek βραχύς, "short" and ουρά, "tail") is a protein that, in humans, is encoded by the TBXT (T-box transcription factor T) gene. Brachyury functions as a transcription factor within the T-box family of genes. Brachyury homologs have been found in all bilaterian animals that have been screened, as well as the freshwater cnidarian Hydra.
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T-box transcription factor 2 Tbx2 is a transcription factor that is encoded by the Tbx2 gene on chromosome 17q21-22 in humans. This gene is a member of a phylogenetically conserved family of genes that share a common DNA-binding domain, the T-box. Tbx2 and Tbx3 are the only T-box transcription factors that act as transcriptional repressors rather than transcriptional activators, and are closely related in terms of development and tumorigenesis. This gene plays a significant role in embryonic and fetal development through control of gene expression, and also has implications in various cancers.
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T-box, brain, 1 is a transcription factor protein important in vertebrate embryo development. It is encoded by the TBR1 gene. This gene is also known by several other names: T-Brain 1, TBR-1, TES-56, and MGC141978. TBR1 is a member of the TBR1 subfamily of T-box family transcription factors, which share a common DNA-binding domain.
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This arrangement is consistent with a model of cis-regulation where the RNA allosterically controls access to the Shine-Dalgarno sequence, thus regulating the gene translationally. aspS genes encode aminoacyl tRNA synthetases. T-box leader RNAs detect low levels of various amino acids, and regulate genes in a cis-regulatory manner. Genes regulated by T-box RNAs often include aminoacyl tRNA synthetases.
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It is possible that aspS RNAs are diverged examples of T-box RNAs, or they might implement a different structural solution to the same biological problem.
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Goering LM et al. 2003. An interacting network og T-box genes directs gene expression and fate in the zebrafish mesoderm. Proc. Natl Acad. Sci. 100:9410-15. 13\.
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George Parr was the leading runscorer with 339 @ 18.83. Other leading batsmen were N Felix, A Mynn, WJ Hammersley, T Box, JM Lee, J Wisden, RT King, J Dean.
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This gene is a member of a phylogenetically conserved family of genes that share a common DNA-binding domain, the T-box. T-box genes encode transcription factors involved in the regulation of developmental processes. This gene is the human ortholog of mouse Tbx21/Tbet gene. Studies in mouse show that Tbx21 protein is a Th1 cell-specific transcription factor that controls the expression of the hallmark Th1 cytokine, interferon-gamma (IFNG).
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This gene is a member of a phylogenetically conserved family of genes that share a common DNA-binding domain, the T-box. T-box genes encode transcription factors involved in the regulation of developmental processes. Knockout studies in mice indicate that this gene is important for specification of paraxial mesoderm structures. Tbx6 is also required for the segmentation of the paraxial mesoderm into somites, and for the normal development of the dermomyotome in zebrafish.
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Functional studies have demonstrated that several T-box genes are involved in mesoderm specification in the developing embryo of mouse or Xenopus. In mice, the Brachyury gene is expressed in early mesoderm cells and its expression then becomes restricted to the notochord. The Brachyury protein binds as a dimer to a 20-nucleotide partially palindromic sequence recognized by its T-domain. More generally, T-box genes have been shown to be critical during development for proper morphogenesis and organogenesis.
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T-box transcription factor Tbx4 is a transcription factor that belongs to T-box gene family that is involved in the regulation of embryonic developmental processes. The transcription factor is encoded by the TBX4 gene located on human chromosome 17. Tbx4 is known mostly for its role in the development of the hindlimb, but it also plays a critical role in the formation of the umbilicus. Tbx4 has been shown to be expressed in the allantois, hindlimb, lung and proctodeum.
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Nature 359:609 –614. 23\. Horb ME, Thomsen GH. 1997. A vegetally localized T-box transcription factor in Xenopus eggs specifies mesoderm and endoderm and is essential for embryonic mesoderm formation. Development 124:1689–1698.
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The evolution of TBR1 has been studied in amphioxi, also known as lancelets. A T-box-containing cDNA was isolated in the lancelet Branchiostoma belcheri and found to possess a T-domain orthologous to that of the T-Brain subfamily of T-box genes, specifically TBR1. However, lancelets lack a true brain and no TBR1 transcripts were found in the neural tissue of the lancelet. This suggests that the neuronal role of TBR1 evolved in vertebrates after the lancelet lineage had already diverged from that of vertebrates.
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Flaccid paralysis is a term used in tactical shooting when a headshot is taken and the bullet enters the cranial cavity in the "T-box". T-box shots are normally made in a situation where the suspect is armed and holding a hostage, usually at gun or knife point. The T-zone is roughly a T-shaped area from the outside of one eye socket to the outside of other eye socket and extending down the bridge of the nose to the upper lip. This area forms the "T" from which it derives its name.
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TBR1 was identified in 1995 by the Nina Ireland Laboratory of Developmental Neurobiology Center at the University of California, San Francisco. The gene, initially named TES-56, was found to be largely expressed in the telencephalic vesicles of the developing forebrain of mice. The protein product of TES-56 was discovered to be homologous to the Brachyury protein, a T-box transcription factor, which plays a role in establishing symmetry during embryonic development. Thus, due to its relation to T-box genes (such as Tbx-1, Tbx-2, Tbx-3), TES-56 was renamed TBR1.
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Extensive intermolecular interactions occur at this site. If the length or orientation of these two recognition points is altered or mismatched, the T box riboswitch and tRNA complex is disrupted, and proper functioning of transcriptional regulation cannot occur.
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T-box gene products are required for mesenchymal induction of epithelial branching in the embryonic mouse lung. Developmental Dynamics226: 82 - 90.Ritvos, O., Tuuri, T., Erämaa, M., Sainio, K., Hilden, K., Saxén, L., and Gilbert, S. F. 1995.
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TBR1 is also known as T-box Brain Protein, T-Brain 1, and TES-56. The encoded protein consists of 682 amino acid residues and has a predicted molecular weight of 74,053 Da. It is composed of 6 exons.
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Ganga, the Telugu version collected share in its first week with a gross of .'Ganga' First Week Collection at AP/T Box Office: Lawrence Starrer Grosses ₹19.3 Crore in 7 Days. Ibtimes.co.in (8 May 2015). Retrieved on 2015-05-29.
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The position of FGF10 expression is regulated by Wnt8c in the hindlimb and Wnt2b in the forelimb. The forelimb and the hindlimb are specified by their position along the anterior/posterior axis and possibly by two T-box containing transcription factors: Tbx5 and Tbx4, respectively.
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Haploinsufficiency of the TBX1 gene (T-box transcription factor TBX1) is thought to be the cause of some of the symptoms observed. Point mutations in this gene have also been observed in individuals with DiGeorge syndrome. TBX1 is part of the T-box family of genes which have an important role in tissue and organ formation during embryonic development and it may have a role in the regulation of differentiation of post migration neural crest cells. The neural crest forms many of the structures affected in DiGeorge syndrome, including the skull bones, mesenchyme of the face and palate, the outflow tract of the heart, and the thymus and parathyroid stroma.
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The Hox genes, which define features along the anterior-posterior axis of a developing organism, determine at which points along the axis that limb buds will form. Though limbs emerge at different locations in different species, their positions always correlate with the level of Hox gene expression along the anterior-posterior axis. All limb buds must also rely on other signaling factors to obtain their forelimb or hindlimb identity; Hox gene expression influences expression of T-box proteins that, in turn, determine limb identity for certain organisms. In turn, the activation of T-box protein activates signaling cascades that involve the Wnt signaling pathway and FGF signals.
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Selected content is available in High Definition. In September 2010 TelstraClear released their own PVR called the T-BOX. The launch followed the release by parent company Telstra (AU) of a similar product. As of June 2011, TelstraClear ceased all analogue transmission on its cable network.
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Tbx5 is a gene that is located on the long arm of chromosome 12. Tbx5 produces a protein called T-box 5 that acts as a transcription factor. The Tbx5 gene is involved with forelimb and heart development. This gene impacts the early development of the forelimb by triggering fibroblast growth factor, FGF10.
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SALL4 has also been reported to bind T-box 5 protein (Tbx5) in cardiac tissues as well as genetically interact with Tbx5 in mouse limb development. Other binding partners of SALL4 include promyelocytic leukemia zinc finger protein (PLZF) in sperm precursor cells, Rad50 during DNA damage repair, and b-catenin downstream of the Wnt signaling pathway.
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Burckhardt A. The small patella syndrome. Z Orthop 1988;126:22–29. Ischiopatellar dysplasia has been identified on region 5.6 cM on chromosome 17q22. Mutations in the TBX4 (T-box protein 4) gene have been found to cause ischiopatellar dysplasia due to the essential role TBX4 plays in lower limb development since TBX4 is a transcription factor.
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Super Fight League 2 took place on April 7, 2012 at the T-Box Mobile Arena in Chandigarh, India. As with Super Fight League 1 it was streamed live on YouTube. A lightweight bout between Paul Kelly and Gabe Ruediger was initially scheduled. It would have fulfilled a pairing that had been planned for UFC 123.
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TBX3 has domains which are important for its transcription factor function which include a DNA-binding domain (DBD) also called the T-box, a nuclear localization signal, two repression domains (R2 and R1) and an activation domain (A). The T-box recognizes a palindromic DNA sequence (T(G/C)ACACCT AGGTGTGAAATT) known as the T-element, or half sites within this sequence called half T-elements, although it can also recognize variations within the consensus T-element sequences. While there are 29 predicted phosphorylation sites in the TBX3 protein only the SP190, SP692 and S720 have been fully characterized. The kinases involved are cyclin A-CDK2 at either SP190 or SP354, p38 mitogen-activated protein (MAP) kinase at SP692 in embryonic kidney cells and AKT3 at S720 in melanoma.
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The human TBR1 gene is located on the q arm of the positive strand of chromosome 2. It is 8,954 base pairs in length. TBR1 is one of the three genes that make up the TBR1 subfamily of T-box genes. The two other genes that form the TBR1 subfamily are EOMES (also known as TBR2) and TBX21 (also known as T-BET).
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There are several providers in Australia, the most prominent being Quickflix (formerly listed on the Australian Stock Exchange) and BigPond Movies. BigPond Movies announced in June 2011 that they will be pulling out of the DVD-by-mail market at the end of September 2011 and are, instead, offering subscribers the option of downloading movies directly via their proprietary T-box device.
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Ball v. United States, 163 U.S. 662 (1896), is one of the earliest United States Supreme Court cases interpreting the Double Jeopardy Clause. In 1889, defendants Millard Fillmore Ball, John C. Ball, and Robert E. Boutwell were indicted for the murder of William T. Box. The jury acquitted Millard Fillmore Ball and convicted John C. Ball and Robert E. Boutwell.
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InHomeTV has also been replaced by VodafoneTV, this is a standard IP streaming service available to anyone in NZ with a broadband internet connection. Content is sourced from FreeToAir suppliers and SkyTV on a subscription basis. In September 2010, TelstraClear released their own PVR called the T-BOX. The launch followed the release by its then-parent company Telstra of a similar product.
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Journal of Cellular Biochemistry, 111(3), 535-542. doi: 10.1002/jcb.22747 This layer is unique in the aspect that these cells migrate to the outer edge of the cortex opposed to the migration experienced by the other 5 layers. Layer one is also characterized by expression of reelin, transcription factor T-box brain 1, and cortical migratory neuronal marker.
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In June 2011, Foxtel launched an over-the-top service on Telstra's IPTV set top box called Foxtel on T-Box carrying the same services as the Foxtel on Xbox service. Also as of June 2011, Foxtel's subscribers numbered just over 1.65 million. In November 2014, Foxtel added 2 new SD channels, 9 new HD channels and rebranded 2 sports channels to satellite and cable subscribers.
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In mice this gene is named "T", but in humans it is named "TBXT". Brachyury has been found in all bilaterian animals that have been screened, and is also present in the cnidaria. The mouse T gene was cloned, and proved that brachyury was a 436 amino acid embryonic nuclear transcription factor. Brachyury binds to the T-box, through a region at its N-terminus.
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The All England Eleven played its inaugural fixture against a Sheffield XX in September. The AEE team was: W Clarke, J Dean, W Dorrinton, F Pilch, A Mynn, J Guy, W Martingell, T Sewell, G Butler, VC Smith and W Hillyer. Other players who represented the AEE in its early days included G Parr, FW Lillywhite, N Felix, W Denison, T Box and OC Pell.
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Expression of Tbx4 is activated by a combined "caudal" Hox code, expressing a specified positional code that includes Pitx1 gene expression. The encoded protein plays a major role in limb development, specifically during limb bud initiation. For instance, in chickens Tbx4 specifies hindlimb status. The activation of Tbx4 and other T-box proteins by Hox genes activates signaling cascades that involve the Wnt signaling pathway and FGF signals in limb buds.
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Digital active signal collector (DASC) antenna is an active antenna for digital signal reception. DASC antennas are often used in DVB-T receivers. With a DASC antenna it is possible to receive DVB-T signals with a small in- house antenna or a relative small outside antenna. The amplifier, built into the antenna, receives it power supply via the coax cable between the DVB-T box and the antenna.
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The company obtained the license for a patented "T-Box" from StadiArena U.K. which converts a 20,000 capacity outdoor ground to a 4,000 capacity pillarless 47,000 sq. feet multi-purpose indoor venue in 6 minutes at a touch of a button. The stadium focuses on maximizing fan engagement and multiplying commercial opportunities. The structure is built with highest standards of quality, safety and security; and is Zone 4 earthquake-resistant.
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Alternative processing and splicing results in at least 4 distinct TBX3 isoforms with TBX3 and TBX3+2a being the predominant isoforms. TBX3+2a results from alternative splicing of the second intron which leads to the addition of the +2a exon and consequently this isoform has an additional 20 amino acids within the T-box DNA binding domain. The functions of TBX3 and TBX3+2a may vary slightly across different cell types.
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Various transcription factors are predicted to bind within the conserved parts of the promoter (upstream regulatory) region, on both the plus and minus strands. The transcription factors with the highest matrix scores include NKX homeodomain factors, GATA-binding factors, two-handed zinc finger, E2F transcription factor, and T-box transcription factors. No vertebrate TATA binding protein factors, RNA polymerase transcription factor II B, CCAAT binding factors, or CCAAT enhancer binding proteins were found.
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The Cardigan is a long, low dog with upright ears and a fox brush tail. The old American Kennel Club standard called it an "Alsatian on short legs". The Cardigan's tail is long (unlike the Pembroke Welsh Corgi, whose tail may be long,Hytönen et al. (2008), "Ancestral T-box mutation is present in many, but not all, short-tailed dog breeds", Journal of Heredity, Advance Access published online on October 14, 2008, naturally bobbed or docked).
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The encoded protein plays a major role in limb development, specifically during limb bud initiation. For instance, in chickens Tbx5 specifies forelimb status. The activation of Tbx5 and other T-box proteins by Hox genes activates signaling cascades that involve the Wnt signaling pathway and FGF signals in limb buds. Ultimately, Tbx5 leads to the development of apical ectodermal ridge (AER) and zone of polarizing activity (ZPA) signaling centers in the developing limb bud, which specify the orientation growth of the developing limb.
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StadiArena is an air-conditioned pillar less multipurpose indoor arena with over 32,000 sq. feet area. The stadium is also equipped with the T-Box facility which provides retractable seating system which enables 5,000 seats to convert from the outdoor arena to indoor arena. It is equipped with world's only turf protection system which gets manufactured from truly translucent HDPE material, it allows for continues photosynthesis while at the same time ensures the optimal turf health, together with a 30 years UV degradation guarantee.
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During embryogenesis, the dermomyotome and/or myotome in the somites contain the myogenic progenitor cells that will evolve into the prospective skeletal muscle. The determination of dermomyotome and myotome is regulated by a gene regulatory network that includes a member of the T-box family, tbx6, ripply1, and mesp-ba. Skeletal myogenesis depends on the strict regulation of various gene subsets in order to differentiate the myogenic progenitors into myofibers. Basic helix-loop-helix (bHLH) transcription factors, MyoD, Myf5, myogenin, and MRF4 are critical to its formation.
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Both of these are unusually small for a modern cipher. The algorithm consists of only 3 passes over the data: a non- linear left-to-right diffusion operation, an unkeyed linear mixing, and another non-linear diffusion that is in fact the inverse of the first. The non-linear operations use a keyed lookup table called the T-box, which uses an unkeyed lookup table called the CaveTable. The algorithm is self-inverse; re- encrypting the ciphertext with the same key is equivalent to decrypting it.
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In 1997, Lustig and Randy King invented an in vitro expression cloning technology used to isolate substrates of kinases and proteases. In 1997, Lustig invented a functional genomics approach to gene discovery and used it to identify a new member of the T-box family of transcription factors (Xombi aka VegT). In 1999 and 2000, Lustig and colleagues showed that bile acids are physiological ligands for the farnesoid X receptor (FXR), invented synthetic liver X receptor (LXR) agonists, and demonstrated that both FXR and LXR ligands regulate cholesterol transport.
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T-box genes are members of a family of transcriptional regulators that contain a region encoding a conserved DNA-binding motif of approximately 200 amino acids: the T-domain. These genes are grouped together on the basis of the homology existing between their products and the mouse Brachyury (or T) protein. In human and mouse, numerous T-domain-containing genes have been identified so far and mapped throughout the genome. The spatio-temporal expression of these genes is strictly regulated during the development of both vertebrates and invertebrates.
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The bZIP interacts with the DNA via basic, amine residues (see basic amino acids in (provided table (sort by pH)) of certain amino acids in the "basic" domain, such as lysines and arginines. These basic residues interact in the major groove of the DNA, forming sequence-specific interactions. The mechanism of transcriptional regulation by bZIP proteins has been studied in detail. Most bZIP proteins show high binding affinity for the ACGT motifs, which include CACGTG (G box), GACGTC (C box), TACGTA (A box), AACGTT (T box), and a GCN4 motif, namely TGA(G/C)TCA.
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During the blastula and gastrula stages, vegetal cells (the presumptive endoderm), release signals to marginal zone cells resulting in the induction and patterning of the mesoderm (1, 8). One of these signals, FGF, achieves this through the regulation of T box transcription factors, a strategy which is shared among Xenopus, mouse and zebrafish (9). Upon FGF binding to its receptor, FGFR, the receptor pair dimerizes and is transphosphorylated, enabling it to recruit proteins that activate Ras and Raf. This is followed by the subsequent phosphorylation of MEK and MAPK.
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This led researchers to look into other candidates of the Wnt pathway. Wnt 11 was found to be located specifically at the vegetal pole prior to cortical rotation and is moved to the dorsal side where it activates the wnt signaling pathway. VegT, a T-box transcription factor, is localized to the vegetal cortex and upon cortical rotation is released in a gradient fashion into the embryo to regulate mesoderm development. VegT activates Wnt expression, so while not acted on or moved during cortical rotation, it is active in dorsal-ventral axis formation.
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Before limb development begins, T-box proteins initiate FGF10 expression in the proliferating mesenchymal cells of the lateral plate mesoderm, which form the limb bud mesoderm. WNT2B and WNT8C stabilize this FGF10 expression in the forelimb and hindlimb, respectively. This FGF10 expression stimulates WNT3 expression in the above ectodermal cells – resulting in formation of the apical ectodermal ridge as well as inducing FGF8 expression. The FGF8 secreted by the AER acts to keep the cells of the limb mesenchyme in a mitotically active state and sustains their production of FGF10.
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For example, we can stipulate that, : \Diamond P = P is the case at some time t : \Box P = P is the case at every time t Or we can trade these operators to deal only with the future (or past). For example, : \Diamond_1 P = FP : \Box_1 P = GP or, : \Diamond_2 P = P and/or FP : \Box_2 P = P and GP The operators F and G may seem initially foreign, but they create normal modal systems. Note that FP is the same as ¬G¬P. We can combine the above operators to form complex statements.
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In terms of structure, the T box RNA is highly conserved—especially in the stem I distal region. The stem I region forms an arched conformation, with the apex containing a complex loop-loop interaction between the conserved adenine-guanine bulge and distal loop. This loop-loop structure is similar to that seen in the ribosome exit site, suggesting that it is highly conserved among tRNA recognition sites. The apex of the stem I region recognizes two critical positions on the tRNA: the anticodon and D/T-loops.
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Scanning electron micrograph of a human T cell Eomesodermin/Tbr2 is highly expressed in CD8+ T cells, but not CD4+ T cells. CD4+ T cells are the helper T cells which detect foreign particles in the body, and call CD8+ T cells to facilitate death of the foreign particles. Eomesodermin/Tbr2 was found to play a role in the anti cancer properties of CD8+ T cells. Lack of Eomesodermin/Tbr2, alongside T bet another T box protein caused CD8+ T cells to not penetrate tumors so they could perform their anti cancer duties.
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A small fragment within this gene can repress the promoter of cardiac troponin I (cTnI) selectively in the atrioventricular canal. T-box factor and NK2-homeobox factor binding element are involved in the repression of the atrioventricular canal without affecting its chamber activity. Tbx2 forms a complex with Nkx2.5 on the ANF gene to repress its promoter activity, so that the gene's expression is inhibited in the atrioventricular canal during chamber differentiation. The atrioventricular canal is also the origin of the atrioventricular nodal axis and helps eventually coordinate the beating heart.
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Tbx4 is a transcription factor and member of the T-box family, which have been shown to play important role in fetal development. Tbx4 is expressed in a wide variety of tissues during organogenesis, including the hindlimb, proctodeum, mandibular mesenchyme, lung mesenchyme, atrium of the heart and the body wall. Tbx4 is specifically expressed in the visceral mesoderm of the lung primordium and governs multiple processes during respiratory tract development such as initial endodermal bud development, respiratory endoderm formation, and septation of the respiratory tract and esophagus. Along with Tbx4, Tbx5 is also expressed to help with development of limbs.
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In particular, three T box transcription factors, Brachyury (frogs) or No tail (fish) (10), VegT (frog) or Spadetail (fish), and Tbx6 (fish and frogs) (11) are important FGF targets that play a key role in mesoderm formation (12,13). In Xenopus, zebrafish and mouse, Brachyury (bra), is required for posterior formation (9). FGF is necessary for the initial localization of Xbra to the dorsal side of the embryo in the marginal zone as well as for establishing and maintaining proper expression of the transcript. Disruption of FGF signaling with an FGFR inhibitor, SU5402, results in loss of Xbra expression in embryos (14,15).
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A natural bobtail can be found in some members of the breed, which is not a mutation of the T-box gene, and so is allowed under conformation show rules. Health-related research on the breed has been limited, with no major studies conducted in Britain. However, it has been included in studies outside the UK, including by the Orthopedic Foundation for Animals (OFA) in the United States. The King Charles Spaniel has a number of eye and respiratory system disorders common to brachycephalic dogs, and endocrine and metabolic diseases common to small breeds, as well as specific breed-associated health conditions.
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When beads were placed in the middle of the flank tissue, the anterior portion expressed Tbx5 and forelimb features, while the posterior portion of the limb expressed Tbx4 and hindlimb features. #When chick embryos were engineered to constitutively express Tbx4 (via viral- transfection) throughout their flank tissue, every limb they grew was a leg, even those that formed in the anterior region, which would normally become wings. This confirms the role of T-box proteins in the type of limb that develops. #Knocking out Tbx4 or Tbx5 knockout prevents FGF10 expression in the lateral plate mesoderm in mice.
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Rhombomeres also lead to the creation of vestibular projection neurons, which are probably produced relatively early in the developmental stages of the brain stem. In the rhombomeres, members of the T-box transcription factor family, have been linked to the proper development of migrating cells. While the hindbrain is developing, trigeminal cell bodies have been shown to migrate dorsolaterally within rhombomeres 2 and 3, while facial cells move dorsolaterally into r5 near the pial surface. Neurons that form the facial nucleus are produced in r4, but move along the anteroposterior axis of the hindbrain into r6, after which they move dorsolaterally.
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Saorview, founded by 2RN, is the name for the Irish FTA DTT. The service was launched as a trial service on 31 October 2010 to 90% of the population and it was officially launched on 26 May 2011. Set-top boxes for the service are available By legislation it must be available nationwide by December 2011. The service is free although a MPEG-4 DVB-T box and a UHF aerial will be needed although some newer TV sets have MPEG-4 DVB-T decoders built into the TV set which do not need a separate box.
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TBX20 (gene) is a member of the T-box family that encodes the transcription factor TBX20. Studies in mouse, human and fruitfly have shown that this gene is essential for early heart development, adult heart function and yolk sac vasculature remodeling and has been associated with congenital heart diseases. Tbx20 was also shown to be required for migration of hindbrain motor neurons and in facial neurons was proposed to be a positive regulator of the non- canonical Wnt signaling pathway. Tbx20 is a transcription factor that is essential for proper heart development in a growing fetus.
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Tbx5 is involved with the development of the four chambers in the heart, the electrical conducting system, and the septum separating the right and left sides of the heart. The Tbx5 gene is a transcription factor that codes for the protein called T-box 5. Along with playing roles in the development of the heart, septum, and electrical system of the heart, it also activates genes that are involved in the development of the upper limbs, the arms and hands. This gene is involved in patterning major aspects of the heart; however, it is also involved in the muscle connective tissue for muscle and tendon patterning.
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The indoor arena lies in the south stand of the stadium and houses the best of technology to convert a 20,000 capacity ground into 4,000 capacity indoor venue for sporting events, expositions, musical events, plays, etc. It uses patented stand convertibility technology from StadiArena UK which makes it the largest convertible convention centre in Asia. It also provides a unique mobile spectator experience using a smart alternative to the conventional brick and mortar modular grandstand spectator seating through T-Box technology that enables sporting events to be constructed, retracted, transformed, removed, downsized and made to disappear within a matter of days. It is a modular, multi-purpose and flexible technique which is helpful in providing efficient space utilization.
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The aircraft, designated the Doak Model 16 by the Doak company and assigned the serial number 56-9642, was originally powered by an Lycoming YT53 turboprop engine mounted in the fuselage, later replaced by a Lycoming T53-L-1 turbine.Harding 1990. The engine drove two wingtip-mounted fiberglass tilting ducted fan propellers through a "T" box on the engine that transmitted power to the propellers via a 4-inch (102-mm) aluminum tubular shaft and two smaller shafts. Each propeller was 48-inch (1.22-meter) in diameter and the duct outer diameter was 60-inches (1.52-meter)). The fans were positioned vertically for takeoff and landing - with a rotation speed of 4,800 rpm required for liftoff - and rotated to a horizontal orientation for horizontal flight, the first time this VTOL propulsion concept was tested successfully.
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Although the exact mechanism of T box leader is still unclear and currently being studied, it has recently been recognized as a member of an expanding group of RNAs that are phylogenetically conserved across many gram-positive bacteria. They are structurally complex and able to directly sense physiological signals which results in the control of downstream gene expression. This controlling of gene expression is accomplished by transcriptional attenuation—a general transcriptional regulation strategy that senses when an alteration in the rate of transcription is necessary and initiating alteration at a particular site (sometimes preceding one or more genes of an operon). The operons that encode aminoacyl-tRNA synthetases, regulated by tRNA-mediated transcriptional attenuation, contain a leader region that specifies a transcript segment that can fold and eventually form a complex set of structures.
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In order for an initial assumption to be an expansion, it must be that a subformula F is entailed if and only if \Box F has been initially assumed true. In terms of possible world semantics, an expansion of T consists of an S5 model of T in which the possible worlds consist only of worlds where T is true. [The possible worlds need not contain all such consistent worlds; this corresponds to the fact that modal propositions are assigned truth values before checking derivability of the ordinary propositions.] Thus, autoepistemic logic extends S5; the extension is proper, since eg \Box p and eg \Box eg p are tautologies of autoepistemic logic, but not of S5. For example, in the formula T = \Box x \rightarrow x, there is only a single “boxed subformula”, which is \Box x.
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The limb field is a region specified by expression of certain Hox genes, a subset of homeotic genes, and T-box transcription factors – Tbx5 for forelimb or wing development, and Tbx4 for leg or hindlimb development. Establishment of the forelimb field (but not hindlimb field) requires retinoic acid signaling in the developing trunk of the embryo from which the limb buds emerge. Also, although excess retinoic acid can alter limb patterning by ectopically activating Shh or Meis1/Meis2 expression, genetic studies in mouse that eliminate retinoic acid synthesis have shown that RA is not required for limb patterning. The limb bud remains active throughout much of limb development as it stimulates the creation and positive feedback retention of two signaling regions: the AER and its subsequent creation of the zone of polarizing activity (ZPA) with the mesenchymal cells.
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There is one promoter region in the ISLR gene with a predicted length of 1,912 bp (Figure 5) extracted from Genomatix. Additionally, there is a polyadenylation signal at 3,142 bp in the ISLR nucleotide sequence (humans). There are six distinct transcription factors that bind onto the promoter region of ISLR from Genomatix predictions: two SMAD factors, sine oculis homeobox (SIX), heat shock factor (HSF), PRDM, Snail, and cell cycles gene homology region (CHR). Genomatix results predicted more transcription factor binding sites in ISLR with the highest matrix similarity (0.97~0.99) such as: # Myeloid zinc finger 1 factor (MZF1) # Nuclear factor of activated T-cells # Hepatocyte nuclear factor 3 (alpha, beta) (FOXA1, FOXA2) # E2F transcription factor 1 # Eomesodermin, TBR-2 (T-box, brain, 2) (Brachyury gene, mesoderm developmental factor) # Homeodomain factor Nkx-2.5/Csx # Estrogen-related receptor alpha (secondary DNA binding preference) # Early B-cell factor 1 (Neuron specific olfactory factor) # Nascent polypeptide-associated complex subunit alpha 1 # IKAROS family zinc finger 3 (Aiolos) # 3' half site of ZTRE motif (zinc transcriptional regulatory element) # AREB6 (Atp1a1 regulatory element binding factor 6) Figure 5.
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