As most American workers are painfully aware, such an acquisition often generates pink slips in an attempt to "synergize" the business.
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And yes, the rounded corners of the Galaxy S8's display definitely synergize nicely with Samsung's predilection for rounded shapes on the screen.
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These will be "meetings from international collaborators getting together to get and compare the research agendas and trying to synergize on research," he said.
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The kinds of markets in which electric cars, home batteries, and solar panels could fully, uh, synergize do not currently exist in most places.
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Android 6.0 Marshmallow works with great fluidity here, and its power optimizations synergize with the efficient 820 chip inside to give the G5 satisfyingly long battery life4.
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But an important question, he added, "is to what degree could combined psychosocial intervention -- cognitive behavioral intervention, for example -- synergize with or at least augment the pharmacological effect" of ketamine.
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Such collaborations will not only address the limited availability of ODA resources to deal with the multitrillion dollar challenge, but also help various development partners complement and synergize their efforts.
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Honestly, just knowing that a product like this is on the market and that people are trying to synergize weed and lube for the sake of orgasms makes me so happy.
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"To synergize food policy, especially strategic goods in the food sector, we will exempt livestock from VAT," said Astera Primanto Bhakti, a member of the special staff of the finance minister.
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Perks have to be unlocked using a variety of in-game resources (which look similar to Destiny's planetary materials), and there are gear sets with specific perks that will synergize together.
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You're the master of extremes, going from highest highs to lowest lows, but figure out how to synergize the two in order to make an informed choice that sits comfortably with you.
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"Using therapies that target different aspects of a cancer, to try to bring them together so that they synergize, that will unquestionably be a real focus in the next half-decade," he said.
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"To synergize food policy, especially strategic goods in the food sector, we will exempt livestock from VAT," said Astera Primanto Bhakti, one of the special staff of the finance minister, without assigning a reason for the removal.
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Phillips Collection Director Dorothy Krosinski also said, "We are proud to be at the forefront of dialogue around these important and timely issues in the U.S." Words like "concerned", "crisis", "important", and "timely" synergize to feel fully political.
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Most of us are familiar with these (still rudimentary) assistive qualities, which synergize nicely with voice controls and natural-language searches to set the stage for a future where we just talk to our smart and informed pocket computers.
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It's augmented reality done in the most unintrusive way possible, and I foresee it being a runaway success because of how well it will synergize with Apple's new bezel-less screen and because of how good the early attempts with it have been.
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During each turn, you're given a number of different buildings which you can place on the island, and location counts for a lot; what you place them near gives you positive or negative amounts of points based on what they synergize with.
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And there's always a "god roll" version of an item to chase after — a perfect hand cannon for Crucible matches, for example, or a perfect bow for world activities — because the assortment of random perks can synergize so well that your gun feels vastly different than the same gun, with different perks.
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Here's the full list of jargon, by state, below: Alabama: value add Alaska: corporate values Arkansas: driven results Arizona: build synergy California: tee up Colorado: change driver Connecticut: leverage expertise Delaware: exhibits good judgement Florida: win-win outcome Georgia: hit your numbers Hawaii: magic happens Iowa: exit strategy Idaho: achieve alignment Illinois: be action-oriented Indiana: fire in the belly Kansas: identify opportunity Kentucky: possess strength Louisiana: synergize Massachusetts: thought leaders Maryland: corporate alignment Maine: goes the extra mile Michigan: eye of the tiger Minnesota: face time Mississippi: bring to the table Missouri: company value Montana: strategic initiative Nebraska: overachiever Nevada: increase productivity New Hampshire: manage escalation New Jersey: in our DNA New Mexico: close the loop New York: herd cats North Carolina: good practice North Dakota: drives change Ohio: out of the park Oklahoma: bleeding edge Oregon: revolutioneering Pennsylvania: message alignment Rhode Island: push the envelope South Carolina: buy in South Dakota: reach out to you Tennessee: touch base Texas: statement of duties Utah: learnings Vermont: KPIs Virginia: not intimidated Washington: through the roof Washington, D.C.: shift the paradigm West Virginia: off the floor Wisconsin: blaze the trail Wyoming: strategic communications
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Rom designed a lung-specific dominant negative p53 mouse that spontaneously developed adenocarcinoma of the lung over 9 months, and that intratracheal benzo(a)pyrene could synergize in causing lung cancer demonstrating gene- environment interaction.
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Lallemand-Breitenbach, V., M.-C. Guillemin, A. Janin, M.-T. Daniel, L. Degos, S.C. Kogan, J.M. Bishop, and H. de The, « Retinoic acid and arsenic synergize to eradicate leukemic cells in a mouse model of acute promyelocytic leukemia », J. Exp. Med., 1999.
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In the opinion of Arnab Das of the Maritime Research Centre at Pune, India, meaningful engagement of the young for nation building is probably the most critical aspect that deserves attention. Multi-disciplinary and multi-functional entities can interact and contribute to synergize their efforts towards a larger goal.
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Sake kasu can commonly be found in Japanese food recipes since it has a distinct taste and also contains yeast and enzymes which can synergize with other food ingredients. Marinating food ingredients in sake kasu can increase the amount of inosine-monophosphate, which is one of the substances that contribute to the umami flavor of the dish.
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Analysts at the time were generally upbeat about the prospects for the bank. Raymond H. Graber of TowerGroup suggested the bank could synergize with the other operations of Sony Financial. Still, Paul Jamieson of Gomez Advisors warned that customers would have high expectations for Sony Bank, given Sony's existing reputation for the ease of use and elegant design of its products.
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Using a DC pulse as the electric current, spark plasma, spark impact pressure, joule heating, and an electrical field diffusion effect would be created. By modifying the graphite die design and its assembly, it was demonstrated to create pressureless sintering condition in spark plasma sintering facility. This modified die design setup is reported to synergize the advantages of both conventional pressureless sintering and spark plasma sintering techniques.
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Mukhopadhyay was a renowned writer and thinker and combined nationalism with rationalism in his works. He strived to reform Hindu customs and family laws to synergize with modern times. He had an immense knowledge of Sanskrit, as evidenced by his numerous essays, and critiques of Sanskrit literature. He wrote several books for young people, historical novels and fused many different philosophies into characters he portrayed.
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Cannabis cofactors have also been linked to lowering body temperature, modulating immune function, and cell protection. The essential oil of cannabis contains many fragrant terpenoids which may synergize with the cannabinoids to produce their unique effects. THC is converted rapidly to 11-hydroxy-THC, which is also pharmacologically active, so the euphoria outlasts measurable THC levels in blood. THC and cannabidiol are neuroprotective antioxidants.
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The D-motifs found in MKK7 are highly specific for JNKs, but have a relatively low binding affinity. It was suggested that the motifs of MKK7 can synergize with each other to provide an efficient substrate phosphorylation It has been shown that all three D-motifs are necessary for correct JNK1:MKK7 complex formations, and for the phosphorylation and activation of JNK1 by MKK7.
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One of Karen-Lisbeth Rasmussen's main accomplishments has been the transformation of Spinderihallerne in Vejle, Denmark (an abandoned cotton factory) into a respected exhibition space and artist's "commune". In 2003 the project was awarded a multimillion dollar grant from the Real Dania Foundation to completely refurbish the old cotton mill and combine the art activities with desirable office spaces, thus effectively seeking to synergize art and business activities.
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Kumbhabhishekham is a Hindu temple ritual that is believed to homogenize, synergize and unite the mystic powers of the deity. This process is believed to keep the icon rejuvenated for a period of 12 years. Sri Mariamman Temple's first Kumbhabhishekham was recorded in 1936 whereas the last one has taken place in 2010, during which artisans from Tamil Nadu were brought in to restore the sculptures and murals of the temple.
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Won made his Overwatch League debut on March 21, 2018 against the Florida Mayhem. Months without competing in a competitive environment hurt his performance, and he was unable to synergize well with his team; this would significantly contribute to them subsequently losing the match. The team's struggles continued throughout the season, as they finished the season in ninth place out of twelve. It was not until the 2019 season that Won came into his own.
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First-line treatment consists of warming the patient; more persistent/severe cases may be treated with medications such as tramadol, pethidine, clonidine, and nefopam, which work by reducing the shivering threshold temperature and reducing the patient's level of discomfort. As these medications may react and/or synergize with the anesthetic agents employed during the surgery, their use is generally avoided when possible. The anesthetic ketamine can also be used to manage postanesthetic shivering.
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Studies have shown an absence of emetic side effects within the half-life of the Levonantradol administered. Other studies suggest that cannabinoid agonists can synergize opioid anti-nociception. Cannabinoid receptors are located in nociceptive pathways, and CBs can promote signal transduction in TRP channels. Although Levonantradol relieves nociceptive and postoperative pain, decreases nausea, and improves spasticity in addition to being more effective than placebos, it has yet to be approved as legal medicine.
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The 3rd Alternative thinking involves applying four paradigms: "I See Myself", "I See You", "I Seek You Out", and "I Synergize With You". The first step or paradigm is about coming to know oneself. It is about stepping outside of normal associations and examining personal worth, feelings, and interests. When a person adopts this paradigm and wins the "private victory," he or she is ready to turn toward others, according to Covey's 7 Habits.
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Step 2 Synergize – Professional Development and Organizational Structure for Mentors. At this phase recruited Ignition mentors learn how to do their job by developing leadership skills, understanding how to manage the organization, and planning for a full year of mentorship and activities. At the conclusion of this day committees have formed, and each committee has several well developed goals to guide their efforts in preparation the first day. Step 3 Train – Facilitation Training for Mentors and Preparation for Orientation.
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These same genes did not show significant expression changes in healthy cells upon treatment with Mdcec. This suggests a degree of specificity which has promise for development of novel cancer therapies. Further supporting therapeutic efficacy, a study of cecropin A affirmed that cecropin A selectively lyses leukemia cells while exerting little effect on normal lymphocytes. In the same study, chemotherapy drugs cytarabine and 5-fluorouracil synergize with cecropin A in vitro to enhance cytotoxic effects on leukemia cells.
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If more than one character's ATB gauges are full, they will perform actions in the order in which instructions are issued to them. Each character may equip "Spritnite" crystals on their gear. These crystals grant both passive bonuses and the abilities on the "Techs" menu. Some of these Techs can synergize together into a new attack; for instance, the spinning "Cyclone" and rushing "Charge" techs can become "X-Strike," a two-person attack directed at one enemy.
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In fact, aberrant transcripts from this gene have been found in about half of all esophageal, stomach, and colon carcinomas. Though the exact molecular function of FHIT is still partially unclear, the gene works as a tumor suppressor as it has been demonstrated in animal studies. Furthermore FHIT has been shown to synergize with VHL, another tumor suppressor, in protecting against chemically - induced lung cancer. FHIT also acts as a tumor suppressor of HER2/neu driven breast cancer.
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First day Vedic rituals of Kumbhabhishekham of the restoration of the Gunjanarasimha Swamy Temple Kumbhabhishekham, also known as Samprokshanam is a Hindu temple ritual that is believed to homogenize, synergize and unite the mystic powers of the deity. It is part of the consecration ceremony of Hindu temples. Kumbha means the Head and denotes the Shikhara or Crown of the Temple (usually in the gopuram) and abhisekham or prokshanam is ritual bathing. Kumbhabhishekham is widely celebrated as a festival in South India.
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Katabon Mosque () in Shahbag, Dhaka is a center for Muslim missionaries in Bangladesh. It houses the Bangladesh Masjid Mission (Bangladesh Mosque Mission) and is officially named as the "Bangladesh Masjid Mission Complex Central Mosque".Bangladesh Yellow Pages Bangladesh Trade Zone Bangladesh Trade Info It is founded at the stables of Dhaka Nawab Family. The mosque houses the Islamic Economics Research Bureau, which works to "synergize the intellectual capabilities of the modern day professionals, academicians, and students of Islamic banking and finance".
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The 3rd Alternative: Solving Life's Most Difficult Problems, published in 2011, is a self-help book by Stephen Covey, also the author of The Seven Habits of Highly Effective People. In it, he takes a more detailed look at habit six from that book, "synergize". Co-author Breck England stated that The 7 Habits of Highly Effective People leads up to The 3rd Alternative. The book focuses on a process of conflict resolution that Covey said is distinct from compromise.
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MALT1 and Bcl10 thought to synergize in the activation of NF-κB, and the deregulation of either of them may contribute to the same pathogenetic process that leads to the malignancy. Bcl10 is evolutionary conserved since cnidaria and has been shown to be functionally conserved all the way back to zebrafish. Notably, just like the upstream CARD- CC family, Bcl10 is absent in insects and nematodes, and the correlated phylogenetic distribution of Bcl10 and CARD-CC proteins indicate a conserved complex.
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The differentiation and proliferation of CFU-GEMM are promoted by growth factors, such as interleukins and cytokines. IL-3 and GM-CSF as single factors are equally active in stimulating CFU-GEMM, but the combination of both factors produces additive stimulatory effects upon CFU-GEMM. The growth of CFU-GEMM is stimulated by the stem cell factor, or SCF. SCF has been found also to synergize with GM-CSF, IL-6, IL-3, IL-11 or erythropoietin to increase the numbers of CFU-GEMM.
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In 2004, SPH television operations SPH MediaWorks was taken over by MediaCorp. However, UnionWorks was not directly affected by the merger. Variety host Quan Yi Fong, and newscasters Helen Cheung (Zhang Haijie) and Wang Yanqing, who left SPH MediaWorks, became regular talkshow guests on UFM 1003's morning drive time show. In an effort to synergize with SPH's other media platforms, UFM 1003 began to host news broadcasts, with daily broadcasts from Lianhe Zaobao, Lianhe Wanbao, Shin Min Daily News, The Straits Times and The New Paper.
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Upon binding to its cis-element, an activator can recruit polymerase directly or recruit other factors needed by the transcriptional machinery. An activator can also recruit nucleosome modifiers that alter chromatin in the vicinity of the promoter and thereby help initiation. Multiple activators can work together, either by recruiting a common or two mutually dependent components of the transcriptional machinery, or by helping each other bind to their DNA sites. These interactions can synergize multiple signaling inputs and produce intricate transcriptional responses to address cellular needs.
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During an observation in 1909 by Flammarion with an telescope, irregular patterns were observed, but no canali were seen. Starting in 1909 Eugène Antoniadi was able to help disprove the theory of Martian canali by viewing through the great refractor of Meudon, the Grande Lunette (83 cm lens). A trifecta of observational factors synergize; viewing through the third largest refractor in the World, Mars was at opposition, and exceptional clear weather. The canali dissolved before Antoniadi's eyes into various "spots and blotches" on the surface of Mars.
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While in a town or staging area, a character's skill and attribute selection can be freely modified to construct a "build". Once in a combat zone (such as an explorable area or a PvP arena), the build becomes immutable until the character exits the combat zone and returns to a staging area. Players generally either choose a specific build for a given area or role, or use builds that synergize with the builds of other characters in the party. A player's ability to help the party is based on the way a player's "build" works.
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In this relation, I-SAPS started reporting education budgets in Pakistan in 2007-08. Each year, the Institute publishes its report on the state of education financing which analyzes the trends in education spending in Pakistan at Federal, provincial and district levels. The latest report in the series analyzed education budgets in Pakistan for a period of 2010-11 to 2015-16. I-SAPS has also facilitated the creation of Pakistan's National Caucus on Education with an aim to synergize the political and technical sides of education reforms in the country.
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While in a town or staging area, a character's skill and attribute selection can be freely modified to construct a "build". Once in a combat zone (such as an explorable area or a PvP arena), the build becomes immutable until the character exits the combat zone and returns to a staging area. Players generally either choose a specific build for a given area or role, or use builds that synergize with the builds of other characters in the party. A player's ability to help the party is based on the way a player's "build" works.
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A trifecta of observational factors synergize; viewing through the third largest refractor in the World, Mars was at opposition, and exceptional clear weather. The canali dissolved before Antoniadi's eyes into various "spots and blotches" on the surface of Mars. Antoniadi's use of the Meudon refractor (often called the 33 inch) added to a growing body of evidence from astronomer's around the world using large telescopes that were not seeing the canals of Mars. There was a counter-theory that small telescopes, in which the canals could sometimes be seen, were somehow better than larger telescopes, in which the canals could not.
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Psoriasis is an auto- inflammatory skin disease characterized by circumscribed, crimson red, silver- scaled, plaque-like inflammatory lesions. Initially, psoriasis was considered to be a Th1-mediated disease since elevated levels of IFN-γ, TNF-α, and IL-12 was found in the serum and lesions of psoriasis patients. However, the finding of IL-17-producing cells as well as IL17A transcripts in the lesions of psoriatic patients suggested that Th17 cells may synergize with Th1 cells in driving the pathology in psoriasis. The levels of IL-17A in the synovium correlate with tissue damage, whereas levels of IFN-γ correlate with protection.
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A few dozen English verbs are derived from the corresponding Greek verbs; examples are baptize, blame and blaspheme, stigmatize, ostracize, and cauterize. In addition, the Greek verbal suffix -ize is productive in Latin, the Romance languages, and English: words like metabolize, though composed of a Greek root and a Greek suffix, are modern compounds. A few of these also existed in Ancient Greek, such as crystallize, characterize, and democratize, but were probably coined independently in modern languages. This is particularly clear in cases like allegorize and synergize, where the Greek verbs ἀλληγορεῖν and συνεργεῖν do not end in -ize at all.
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Together, the inhibitory signaling effects (particularly of PKCε and PI3k) and the presence of ROS synergize to induce autophagy. Following autophagic activity, cell death is eventually induced by an as of yet unknown mechanism. Missing from this cellular death are any signs of apoptotic induction such as characteristic changes to nuclear morphology and PARP cleavage.Sachs, C. W., Safa, A. R., Harrison, S. D., & Fine, R. L. (1995). Partial inhibition of multidrug resistance by safingol is independent of modulation of P-glycoprotein substrate activities and correlated with inhibition of protein kinase C. Journal of Biological Chemistry, 270(44), 26639-26648.
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The first p97 inhibitor Eeyarestatin (EerI) was discovered by screening and characterizing compounds that inhibit the degradation of a fluorescence-labeled ERAD substrate. The mechanism of p97 inhibition by EerI is unclear, but when applied to cells, it induces biological phenotypes associated with p97 inhibition such as ERAD inhibition, ER stress elevation, and apoptosis induction. Importantly, EerI displays significant cancer-killing activity in vitro preferentially against cancer cells isolated from patients, and it can synergize with the proteasome inhibitor bortezomib to kill cancer cells. These observations prompt the idea of targeting p97 as a potential cancer therapy.
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Thymosin α1 (TA1), a molecule with immune enhancing properties, was the first of the Thymosins to enter clinical trials. It has been approved in China and more than 30 other countries, and has shown great promise in the treatment of severe sepsis, cancer, and a number of other diseases including the potential treatment of cystic fibrosis. Most recently, TA1 has been found to synergize with a check-point inhibitor and further extend the survival of Stage III/IV melanoma patients previously treated with TA1. Thymosin β4 (Tβ4), the second of the Thymosins to reach the clinic, has been shown to accelerate wound healing and the remodeling of injured tissues.
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Rom designed a lung-specific dominant negative p53 transgenic mouse that spontaneously developed adenocarcinoma of the lung over 9 months, and after intratracheal benzo(a)pyrene could synergize in causing lung cancer demonstrating gene-environment interaction. Rom founded and directed the NYU Lung Cancer Biomarker Center that was part of the NCI Early Detection Research Network (2001-2015). His findings in collaborative studies for early detection of lung cancer focused on networks of immune response, metabolism, growth factors and receptors, signaling pathways, cytokines, and altered methylation biomarkers. Rom WN, Goldberg JD, Addrizzo-Harris D, Watson HN, Khilkin M, Greenberg AK, Naidich DP, Crawford B, Eylers E, Liu D, Tan EM. Identification of an autoantibody panel to separate lung cancer from smokers and nonsmokers.
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In 2019, NBCUniversal parent company Comcast acquired the British telecom and media conglomerate Sky plc. As a result, the NBC Sports division became a sibling to Sky Sports, a domestic rightsholder of the Premier League in the UK. Sky began to synergize with NBC Sports throughout 2019, beginning with a collaboration with its reporters for coverage of the transfer deadline, and adding a weekday simulcast from its Sky Sports News channel to the daytime lineup of NBCSN. On-air collaboration with Sky Sports intensified with the beginning of the 2019–20 season; as Sky holds the first pick of matches for 12:30 p.m. (Eastern Time) kickoffs under its renewed contract, NBC will be able to air more prominent matches in its early-afternoon broadcasts.
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PAC-1 is notable for the unique path it has taken to the clinic, as it is possibly the only cancer drug to first be rigorously evaluated in pet dogs with spontaneous cancer as a prelude to the human clinical trial. In 2010, a study showed PAC-1 to be safe for dogs, and a second study published later that same year reported that a PAC-1 derivative (called S-PAC-1) was well tolerated in a small phase I clinical trial of dogs with lymphoma. More recently, in addition to this single-agent activity PAC-1 has shown to potently synergize with approved cancer drugs, for example with doxorubicin in the treatment of pet dogs with lymphoma and metastatic osteosarcoma, and with temozolomide in treating pet dogs with spontaneous glioma.
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From The Airport came together in early 2012 when Milo (Producing, Guitar, Bass, Keys, Vocals) and Zee (Producing, DJ, Drums, Keys, Vocals) met at a friend's underground studio. They quickly realized they both had very similar musical taste and style and arranged to do a jam session for fun. During the session, the duo‟s natural chemistry led them to experiment and create the product of which was the foundation for their first track “Colors.” Both Milo and Zee have a nice blend of experiences prior to teaming up. Milo’s guitar mastery and composing prowess were honed from film music production (Jesus Band, Korea, Shirano Agency) and Zee developed on the keys and DJ/producing while composing for K-pop music scene (Banana Dynamite, MC Sniper, J). Together, their collaborative abilities and skills synergize to create From The Airport’s unique sound.
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Any class-specific Classic cards retired in this manner are eventually replaced with new Classic cards for that class to prevent class card-count imbalances. At the start of Year of the Dragon in April 2019, two legendaries from The Witchwood set that powers up the hero power, Genn Greymayne and Baku the Mooneater, as well as four cards that synergize with those cards, were moved to the Hall of Fame so those cards left the Standard set a year earlier than normal. Prior to the year moniker system, the Reward set consisted of four cards that could only be obtained by completing meta-game achievements in Hearthstone, such as by collecting at least one copy of every "murloc" card in the Basic and Classic sets. As with other Classic cards, these have since been retired to the Hall of Fame, still usable in Wild play and available through crafting.
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Similarly, humans with homozygous splice variants in CD79A predicted to result in loss of the transmembrane region and a truncated or absent protein display agammaglobulinemia and no peripheral B cells. The CD79a ITAM tyrosines (human CD79a Tyr188 and Tyr199, mouse CD79a Tyr182 and Tyr193) phosphorylated in response to BCR crosslinking, are critical for binding of Src-homology 2 domain-containing kinases such as spleen tyrosine kinase (Syk) and signal transduction by CD79a. In vivo, the CD79a ITAM tyrosines synergize with the CD79b ITAM tyrosines to mediate the transition from the pro to the pre B cell stage as suggested by the analysis of mice with targeted mutations of the CD79a and CD79b ITAM. Loss of only one of the two functional CD79a/b ITAMs resulted in impaired B cell development but B cell functions such as the T cell independent type II response and BCR mediated calcium flux in the available B cells were intact.
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Rumbo, Joseph D. (2002) "Consumer Resistance in a World of Advertising Clutter: The Case of Adbusters", Psychology & Marketing 19(2): 127–48. Others posit that the culture jamming strategy of rhetorical sabotage, used by Adbusters, is easily incorporated and appropriated by clever advertising agencies, and thus is not a very powerful means of social change. More positively, some practitioners have called for moving beyond the negative sense of "jamming" to the more positive, musical understanding of the term that would encourage artists, scholars and activists to come together and literally "jam" in the best musical sense of the term—to synergize and in so doing augment and amplify their experiences and ideas to create new, innovative, flexible and praxically mobile art, intellectual and political concepts, strategies and actions that together would offer deeper, more compelling and even transformational visions of futures in which, as the Zapatistas have taught, many worlds are possible.
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Therefore, by controlling the dosage, one can achieve selectivity between normal and cancerous cells. In addition to its stand-alone activity, PAC-1 has also been shown to markedly synergize with a variety of approved cancer drugs, for example with BRAF and MEK inhibitors in mouse models of melanoma, and with conventional chemotherapeutic agents such as doxorubicin in pet dogs with spontaneous cancers including lymphoma and metastatic osteosarcoma, and with temozolomide in pet dogs with naturally occurring glioma. Vanquish Oncology reported their intention to begin a Phase I human clinical trial in cancer patients to begin in early 2015, and indeed the Phase 1 trial of PAC-1 opened for enrollment in February 2015 (NCT02355535). This trial is being conducted at the University of Illinois Cancer Center in Chicago, at the Sidney Kimmel Cancer Center at Johns Hopkins, and at Regions Hospital in St. Paul, MN. A Phase 1b trial of PAC-1 plus temozolomide opened in late 2017 at the same three sites (NCT03332355); patients with high grade glioma (glioblastoma multiforme (GBM) or anaplastic astrocytoma) after progression following standard first line therapy are eligible for this trial.
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