Diamox, a non-antibiotic sulfa drug, speeds up your breathing rate so that you acclimatize more quickly, according to the American Alpine Institute.
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Sulfathiazole is an organosulfur compound used as a short-acting sulfa drug. Formerly, it was a common oral and topical antimicrobial, until less toxic alternatives were discovered. Sulfathiazole exists in various forms (polymorphs). The imine tautomer is dominant, at least in the solid state.
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The arsphenamines was then made available in 1910, known as Salvarsan. In 1929 Alexander Fleming developed the most commonly used antibiotic substance both at the time and now: penicillin. In 1939 Gerhard Domagk found Prontosil red protected mice from pathogenic streptococci and staphylococci without toxicity. Domagk received the Nobel Prize in physiology, or medicine, for the discovery of the sulfa drug.
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The sulfa drug Sulfathiazole was one of the results of these research activities. The company Tika was acquired in 1939, and the pharmaceutical factories of Paul G. Nordström in Hässleholm (later renamed to Hässle, and operated as a division of Astra) in 1942. This established Astra as the leading Swedish pharmaceutical company. In the 1940s, two product families were established which were to become quite important to Astra: penicillin and anaesthetics, initially in the form of Xylocain, which was introduced on the Swedish market in 1948.
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The first synthetic antimicrobial drug, arsphenamine, discovered in 1909 by Sahachiro Hata in the laboratory of Paul Ehrlich, is not toxic to bacteria until it has been converted to an active form by the body. Likewise, prontosil, the first sulfa drug (discovered by Gerhard Domagk in 1932), must be cleaved in the body to release the active molecule, sulfanilamide. Since that time, many other examples have been identified. Terfenadine, the first non-sedating antihistamine, had to be withdrawn from the market because of the small risk of a serious side effect.
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Sterling, who manufactured British Army weapons and Jaguar car parts, were also based in Dagenham until they went bankrupt in 1988. Other industrial names once known worldwide were Ever Ready, whose batteries could be found in shops throughout the Commonwealth, Bergers Paint and the chemical firm of May & Baker who in 1935 revolutionized the production of antibiotics with their synthetic sulfa- drug known as M&B; 693\. The May & Baker plant, owned and run by Sanofi- Aventis, occupied a 108-acre site in Rainham Road South, near Dagenham East Underground station. It was abandoned in 2013 when the company closed it.
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Thomas Hager, The Demon Under the Microscope (2006) (cited in "The Saga of a Sulfa Drug Pioneer" – NPR Weekend Edition 23 December 2006)NobelPrize.org (This was because the Nazi-critical Carl von Ossietzky had won the Nobel Peace Prize in 1935, which had angered the German government and resulted in German nationals not being permitted by law to accept the Nobel Prize.) In the same year, Domagk was also awarded the Cameron Prize for Therapeutics of the University of Edinburgh. In 1941 Domagk was awarded the Medaglia Paterno (Rome) by the Kingdom of Italy and also the Von-Klebelsberg- Medal and Prize by the Kingdom of Hungary. He became a member of the German Academy of Sciences Leopoldina in 1942.
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