The AVOD product right now is actually going through the development phase and the specking of it.
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" Even in Anchorage, about 230 miles from the epicenter, Mr. Specking said, "You could look over down the hall and see everything shaking.
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I.O., specking public appearances with protect-the-little-guy anecdotes from his watchdog role in the hope that voters will not mistake boring for moderate.
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"It was pretty crazy because for a while I just had to calm the people down," said Michael Specking, who works at the front desk of the hotel.
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Koperberg alleges that Gibson was behind the 2006 plot to discredit his reputation and accused Gibson at the time of running a smear campaign against him that "bordered on evil". Central to the tension between Koperberg and Gibson was that in 1994, Koperberg parted from his wife after suspecting that Specking and Gibson were having an affair. Gibson and Specking (who had been Gibson's electorate secretary) went on to have a relationship lasting ten years.
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On 9 January 2008, the police handed the results of their investigation into Koperberg to the NSW Director of Public Prosecutions. The Sydney Morning Herald reported that there was speculation Specking and Coad were not prepared to make statements to the police, making it likely Koperberg would be cleared. On 17 January the prospect of any charges being laid was dismissed. Koperberg resigned from the New South Wales Ministry on 22 February 2008, citing ill health.
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He resigned as Minister of Justice in 1953, after Prime Minister Sir John Kotelawala requested his resignation from the cabinet and returned to his legal practice. In 1965, he actively campaigned for the United National Party, specking of authoritarian actions of the Sri Lanka Freedom Party, following its attempts to nationalize Lake House. Following the United National Party victory in the 1965 general elections, he was appointed Ceylon's Ambassador to France in 1965. In February 1967 he was appointed the Ceylon's High Commissioner to the United Kingdom which he held until October 1969.
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In the aftermath of the election, it was revealed that Koperberg's ex-wife Specking had been involved in an affair with Paul Gibson, the Member for Blacktown and as a result the two men were bitter rivals. Koperberg had in fact earlier suggested Gibson was behind the domestic violence allegations, accusing him of running a smear campaign "bordering on evil". However, Gibson was dumped from Cabinet almost immediately when he was accused of assault against an ex-lover, former Minister for Sport Sandra Nori, in 1991. Police later found Gibson had no case to answer.
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Following union pressure for Gibson to be included in the NSW Ministry and Cabinet Premier Morris Iemma announced on 30 March 2007 that Gibson would become Minister for Sport, Minister for Western Sydney, and Minister Assisting the Minister for Roads (Road Safety). However, immediate conflict arose due to an existing hostile relationship with the Member for the Blue Mountains Phil Koperberg. Elected at the 2007 NSW state election, Koperberg was immediately appointed to the Ministry and Cabinet as Minister for Climate Change, the Environment and Water. When Koperberg sought preselection for Blue Mountains in 2006, Labor officials were secretly notified (by way of an affidavit) that an apprehended violence order had been sought in 1987 by Koperberg's former wife, Katherine Specking.
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On 2 December 2007, the claims regarding Koperberg's violence toward Specking re-emerged, this time with the additional implication that he had also assaulted his stepdaughter Paula Coad "with such force that one of her fillings was knocked out". Further claims were laid that the NSW Labor Party knew of the allegations before Koperberg's nomination for election and attempts were made to cover them up. Koperberg maintains he openly declared the allegations during the pre-selection process. While Koperberg continues to deny any wrongdoing, he was stood down from the front bench of Parliament the following day while a police inquiry was instigated into the allegations, primarily due to pressure on Iemma to take action in light of the allegations against Gibson in March.
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MIA is composed of two main essential cysteine-rich proteins; Mia40 and Erv1. Mia40 is also referred to as Tim40 in yeast and deficiency of Mia40 has been reported to affect import of the small Tims. Mia40 is anchored to the mitochondrial inner membrane via an N-terminal hydrophobic segment, exposing a large domain to the intermembrane space. It contains 6 conserved cysteine residues, which allow the binding of incoming Tim precursor proteins.Chacinska, A., Pfannschimdt, S., Wiedemann, N., Kozjak, V., Sanjuán Szklarz, LK., Schulze-Specking, A., Truscott, KN., Guiard, B., Meisinger, C., Pfanner, N.(2004) Essential role of Mia40 in import and assembly of intermembrane space proteins. EMBO J 23: 3735-3746. Following import of small Tim proteins into the intermembrane space Mia40 interacts with small Tim proteins via disulfide bonds. Following isomerisation of the disulfide bridge, the polypeptide is released. Mia40 which is now in reduced state, is then oxidised by Erv1.Tokatlidis, K. (2005) A disulphide relay system in mitochondria.
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On 2 November 2006 Koperberg announced his intention to seek Labor Party preselection for the state seat of Blue Mountains in the New South Wales Legislative Assembly at the 2007 state election after Attorney-General and Environment Minister Bob Debus announced he would not recontest his safe Labor seat. > "The move comes despite denials as late as this week by Mr Koperberg that he > had no plans to seek preselection in the seat which Labor holds by a 14.8 > per cent margin. Mr Koperberg's years of high profile work fighting fires > would make him a popular choice for the bushland electorate." Almost immediately, it was revealed that Koperberg had been issued with an Apprehended Violence Order in 1987 after a domestic violence incident involving his wife of the time, Katherine Specking. On 6 November, Sydney radio personality Alan Jones made comment on air in response to these revelations: On 12 January 2007, Koperberg stood down from his role as RFS Commissioner in order to begin his campaign for political office.
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