420 Sentences With "specificities" | Random Sentence Generator

To say that Trump's platform lacked policy specificities is an understatement.

Crazy Rich Asians focuses on the specificities of elitist Asian class politics.

Yet by the latter date of 2008, these specificities began to unravel.

He is very well aware of specificities of race in this country.

Some had sensitivities and specificities pretty close to the ideal of 100.

These specificities don't bog down the series, they help to make it better.

Working in the UAE means that certain cultural specificities must be designed around.

He adds "we maintain an advanced knowledge of the specificities of each country in terms of communication rules, and telco specificities," which makes it easier for Wavecell to advise clients when they tailor its APIs to their own use cases.

"The work of the Basel (Committee) should not question virtuous national specificities," Villeroy said.

At the same time, each case has its specificities and involves complex legal questions.

"These national specificities should be reviewed," Ophele told the annual IDX derivatives industry conference in London.

Like all of Wiseman's work, Model is observational and rooted in the specificities of social codes.

And each country has its characteristics and specificities and social fabrics and different unions, different political parties.

Athleticism is usually identified and easily understood in a series of specificities—blinding speed, towering leaps, smashing through.

It's important that women are included in running events, that the specificities of our bodies and lives are considered.

"When you combine antibodies that have different specificities, you decrease the chance of creating immunization-resistant viruses," says Ruprecht.

The biographical specificities of silhouettes of white individuals, in other words, were also centrifugal, created outside the objects themselves.

Ms. deBessonet focuses on the way the characters, of whatever world, reflect varieties rather than specificities of human affection.

While the overarching storylines of "Teddy Perkins" and White Face are notably different, the overlapping specificities are hard to ignore.

This is mainly because vertical software is much more geography-dependent (local legal specificities, local industry rules, customers, culture, etc).

"Those observers understand the language and are trained on the regional specificities of the respective fan cultures," said the statement.

In doing so, she also turns away from the specificities of the Bosnian war (though she later returns to them).

A systematic review of them found that they had sensitivities greater than 85 percent and specificities greater than 90 percent.

I think it's important to highlight the specificities of this ecosystem — taking risks is important when you are an entrepreneur for example.

With mercy and charity claimed as Jewish specificities, the sarcasms of the book at last rise and resolve into something like poetry.

You get older, and your idea of success changes from generic astronomical stardom to something more personal, shaped around the specificities of your dreams.

When I'm driving my car on a new road, I can learn about it: some of its specificities or dangers, like a hazardous turn.

"We have to think about the specificities of the European economy and the European banking sector," he said at a European Parliament hearing on Tuesday.

I question him on the specificities of fake reviewing; the shed opening night; the amount of brothers Oobah has, and their names—all of it.

I asked Gant to elaborate on some of these other specificities that aren't apparent in his Instagram posts, and he laid them out to me.

In this, curators play a decisive and extremely delicate role because they must construct a frame of meaning that responds to the specificities of his practice.

Funnily, the specificities of the Qing dynasty, which lasted from 1644–1912, a period when the arts flourished, never quite made it into the exhibition design.

Even at a young age, Denise is aware of the cultural specificities: "Being gay isn't something black people love to talk about," she patiently explains to Dev.

It is quite a time-consuming process involving various painting techniques with their inherent specificities; hence I usually work on each painting for a couple of years.

"We're fully aware of Mosul's specificities and the difficulties on the ground ... but it's exactly because the situation is still fragile that we need to act," Azoulay said.

When fear fuels violence and violence proliferates fear, against all that have reduced humankind to vicious specificities, it is to this one sign that we must inevitably return.

The European Commission said the new rules proposed by the Basel Committee will be applied in the European Union taking into account "specificities" of the bloc's banking sector.

The psychology students whose thesis project this experiment exists for ask their subjects: Do they embrace the history, meaning, and specificities of the black experience in their relationships?

In the first half of the year, Tiffany will roll out the provenances for all of their diamonds, as well other specificities typically not found in the industry's lab reports.

With all their quirks, specificities, and perfectly produced personas, you can't help but imagine who would win in a battle to the death between, say, Margot Tenenbaum and M. Gustave.

At times this "we" detracts from the specificities of the central characters, but it works, because this is a story of a generation, a class, a community, a gender, a world.

As cannabis dispensaries flourish across the country alongside the push to legalize medicinal and recreational marijuana use, demand for tools to manage the specificities of the weed retail business continues to increase.

"The people running onboarding didn't do much training in terms of the specificities of the challenges that we would be facing," an ex-Twitter employee who worked alongside Abouammo told BuzzFeed News.

CBK regulations are comparable between conventional and Islamic banks, but they take account of Islamic banks' specificities, such as the 50% Alpha factor used to calculate specific real estate risk-weighted assets.

Last year's events were a raucous beginning, but it was during this year at GDC where the focus was on the mechanics and specificities of growing and sustaining a healthier games labor industry.

And when considering the specificities of a cybersecurity strategy there are key considerations that decision-makers should consider to maximize outcomes: the understanding that we cannot tacitly endorse the cybersecurity status quo any longer.

"Having the real virus means we now have the ability to actually validate and verify all test methods, and compare their sensitivities and specificities," the Doherty Institute's virus identification laboratory head, Julian Druce, said.

And then the "screenplay sort of stalled in people's drawers," as producers waited for the right black director — something her husband felt was necessary, she said, to bring respect and attention to cultural specificities.

"We have put forward new risk reduction proposals that build on the agreed global standards while taking into account the specificities of the European banking sector," said Valdis Dombrovskis, the EU commissioner on financial services.

"The complexity of that medium, the specificities around things like, not only however many frames per second, but then adding in things like making meaning out of what has been recorded, is very difficult," she said.

"Having the real virus means we now have the ability to actually validate and verify all test methods, and compare their sensitivities and specificities", the Doherty Institute's virus indentification laboratory head, Julian Druce, said in a statement.

The explanation is simple: Irrespective of political specificities and personal misconduct, Trump delivered on the original promise of his election — namely heaping abuse on Washington insiders, embracing political chaos and caring little about norms, expertise and legalities.

The former students accurately paint the picture of all-girl Catholic school life, from the nervous excitement of waiting for high school acceptance letters down to the specificities of saddle shoes—details so familiar they made me cringe.

Thus, Torn juggles with a combination of tools—including Photoshop, Maya 3D animation, a bunch of modeling softwares and even a liquid simulator called Real Flow—allowing her to embrace the whole space despite the shape and scale specificities.

"It's important to acknowledge the writers engaging in the specificities of actual trans experience," said Talusan, if only to counter a long cultural tradition of transgender people "cast as the other or the villain" (think "Silence of the Lambs").

Nyong'o actually filmed Little Monsters before her phenomenal double-duty turn in Jordan Peele's Us, spending two weeks working with an Australian kindergarten teacher to help her grasp the specificities of professional kid-wrangling as well as the Australian school system.

The specificities of the site are further highlighted by her piece "Inverted Mediterranean Pine" (2019), in which the sculptural remains of a burned tree are placed precariously over an existing hole in the church floor, revealing the foundations and lagoon beneath.

What is missing—the absence is surely intended—is, precisely, the middle: an artifice bold enough to invent and evoke the day-to-day specificities of people whose lives are very different from our own, and whose hardship seems almost unreachable.

Her story, rendered through a series of lyrical vignettes that alternately float through your hand and punch you in the gut, captures both the universal pathos of childhood, and the specificities of life as a Latinx girl moving into womanhood.

True, they propose a campaign to "treasure the talent" at State and USAID, but the relevant recommendations are boilerplate stuff from a freshman year business administration textbook, not reflecting any understanding of the specificities of the unusual agencies under review.

Indifference to political specificities is for once a boon, as it allows Malick to paint Nazism and resistance to it as a moral dichotomy, and suggest in no uncertain terms that any inch given to evil is one inch too many.

Positioning the equator as central to global conversations about artmaking — in spite of whether or not these geographies are perceived as "central" to the mainstream arts world — the Biennale has, over its last five iterations, explored the specificities of art being made there.

Dear White People is full of specificities, references, and utter realness that you didn't know you needed, so much so that it can catch you off guard, like stumbling across a pitcher of water and suddenly realizing you've been thirsty for decades.

Rather than just throw in a few non-white characters to balance out the cast, Netflix's programming slate actively explores the specificities, cultures, and lived experiences of marginalized groups that don't often get to tell their stories—or have them told at all.

"Having the real virus means we now have the ability to actually validate and verify all test methods, and compare their sensitivities and specificities," said Julian Druce, head of the virus identification lab at the Peter Doherty Institute for Infection and Immunity.

She employs insightful close analysis of works by artists such as Mel Chin, Newton and Helen Mayer Harrison, Mierle Laderman Ukeles, and Vik Muniz, to explore the specificities of contemporary waste art and to highlight the diversity of approaches being used to scrutinize global capital.

To spend your time with someone who feels set apart from other people, and to have your specificities highlighted by how your partner appreciates them, draws them out, and combines them with their own to make something rad, shared, and new—aka your relationship.

BRUSSELS (Reuters) - The European Commission said new global banking rules agreed on Thursday will be applied in the European Union taking into account "specificities" of the bloc's banking sector and making full use of the agreed phase-in period until the end of 2026.

"Prudential rules could favour 'green' investments and loans, naturally while keeping prudential considerations in mind," he said, adding that the reform will take into account "European specificities" to avoid increased capital requirements having a disproportionately negative impact on some specific sectors, business models or activities.

I'm a theorist, so I've utilized the term to construct a theory of representation specific to contemporary African-American art: a theory that attempts to unpack the conceptual and aesthetic specificities of post-Civil Rights visual artists, who are creatively reimagining the visual rhetorics of blackness.

When I was young, I felt a high-minded scorn for the whodunits my elders favored: mystery novels that inducted you into the specificities of British racecourses or Native American reservations while satisfying the same itch for neat solutions as my father's games of solitaire, my mother's crossword puzzles.

The nuances, specificities, and friction points vary from issue to issue, but the ultimate reality is the same: While public support for fixing immigration and changing the country's gun control laws is high, members across the Capitol admit that Congress is unable -- and at times unwilling -- to lead social change.

"Being evaluated that way can't help but make you feel that is how they view my contributions," Lim told THR, adding she felt women of color were regarded as "soy sauce" — hired to work on projects solely for cultural specificities on TV and film rather than to substantially shape and tell a story.

"Chinese officials released the genome sequence of this novel coronavirus, which is helpful for diagnosis, however, having the real virus means we now have the ability to actually validate and verify all test methods, and compare their sensitivities and specificities – it will be a game-changer for diagnosis," Druce said in a statement.

At their best, "scene reports" delve into the specificities of a scene, placing it in a larger context and letting its participants speak as much as the reporter, as in the iconic documentary film series by Penelope Spheeris on the Los Angeles punk and heavy metal scenes, The Decline of Western Civilization.

In fact, the very specificities of Page's own dynamic "hands down" style you see in the cage is a direct consequence of the technical demands needed to compete with the elite of the UK/Europe's sport karate scene, an environment he has been a part of since his initiation into martials arts from just three years old.

There are some regional and generational specificities to his various manias, but there is nothing that is not mediocre or entirely predictable, here; he is in every way a replacement-level codger, and there is some downmarket version of him muttering know-nothing bitchery into a tabloid in every diner in every town from sea to shining sea.

Looking at the past with rose-colored shutter shades and treating the notion of "tomorrow" like a looming threat are both common subjects for the ankle-deep reflections contained in EDM lyrics, and despite The Chainsmokers' attempts to elevate the artform by way of scene-setting specificities, they more often than not land in shallow lyrical waters.

Contrast the UI specificities of having an onboard 4K Blu-ray player and a video streaming app drawer with a web browser, a digital storefront, a cloud save, and file and hard drive management system, and you have a dashboard that feels like it needs all the complexities of a full-blown PC. In many ways, an Xbox One already is a PC: the console now runs a slimmed-down version of Windows 10.

Humans are context-seeking creatures, and this need to feel woven into the world takes many forms: research into family history; pride about one's hometown, state, or country and the specificities of these places that have marked one's character, behavior, and speech; nostalgia for a past when people appeared to have stable destinies, when gender roles, social hierarchies, and the "order of things" seemed clearer, and when inherited categories went uncontested; and the pastoral longing to restore a lost communion with the earth itself.

General porins have no substrate specificities, though some exhibit slight preferences for anions or cations. Selective porins are smaller than general porins, and have specificities for chemical species. These specificities are determined by the threshold sizes of the porins, and the amino acid residues lining them. In gram-negative bacteria, the inner membrane is the major permeability barrier.

This discovery was used to re-engineer coenzyme specificities of enzymes.

Different isoforms of RORα have different binding specificities and strengths of transcriptional activity.

As the most variable parts of the molecules, CDRs are crucial to the diversity of antigen specificities generated by lymphocytes.

The protein encoded by this gene is highly homologous to other family members; however, the enzymes have different substrate specificities.

Examples of tetrapolar organisms are the smuts Ustilago maydis and U. longissima, and the mushrooms Coprinopsis cinerea, Schizophyllum commune, Pleurotus djamor and Laccaria bicolor. It is believed that multi-allelic systems favor outcrossing in Basidiomycota. For example, in the case of U. maydis, which bears more than 25 b but only 2 a specificities, an individual has an approximately 50% chance to encounter a compatible mate in nature. However, species such as C. cinerea, which has more than 240 A and B specificities each, and S. commune, which has more than 339 A specificities and 64 B specificities, approach close to 100% chance of encountering a compatible partner in nature due to the huge number of mating types generated by these systems.

Alternative promoter use and alternative splicing results in multiple transcript variants that have different tissue specificities. [provided by RefSeq, Dec 2016].

London: Sage.—and stylistics—which is finely attuned to the grammatical/rhetorical/narratorial specificities of texts as texts.Simpson, P. (2004) Stylistics. London: Routledge.

These loops are responsible for the various substrate specificities. These proteases rely upon binding of lipopolysaccharide for activity. Omptins have been linked to bacterial pathogenesis.

Clerch, B., E. Rivera, and M. Llagostera, Bacteriophage PSP3 and phi R73 activator proteins: analysis of promoter specificities. Journal of Bacteriology, 1996. 178(19): p. 5568-5572.

The substrate specificities of VanX and VanY ensure that essentially only precursors with low affinity for the glycopeptide antibiotics are available for peptidoglycan synthesis in resistant strains.

In France, one hierarchy of road is based on the owner who manages the road. Independently of that, roads can have various specificities such as speed or crossings.

L-lysine 6-transaminase belongs to the aminotransferase class-III family. Crystal structures of L-lysine 6-transaminase reveal a Glu243 “switch” through which the enzyme changes substrate specificities.

GalNAc-Ts have different, but overlapping, substrate specificities and patterns of expression. Transcript variants derived from this gene that utilize alternative polyA signals have been described in the literature.

The high specificities however indicated that a neonate adjudged to be hypothermic or pyretic using the rectal route will also be detected as hypothermic or pyretic by the tympanic route.

The Republican Circle or CRK (Dutch: Republikeinse Kring, French: Cercle républicain, German: Republikanischer Kreis) is a Belgian trilingual republican association that aims to promote republican values and various republican forms of government whilst respecting cultural specificities.

The transference of the epithet to the biography of Rumi's mentor suggests that this Imam's biography must have been known to Shams-i Tabrīzī's biographers. The specificities of how this transference occurred, however, are not yet known.

The latter two receptors were subsequently found to have very different specificities for the formyl oligopeptides and very different functions than those for FPR1. FPR1 is the premiere receptor for the pro- inflammatory actions of formyl peptides.

He does not compare these two events but instead introduces a typology of disasters that locates them within the wide spectrum of calamities generated by humans to exhibit both the specificities and general patterns that subsequently emerge.

Brand, Fischer, Harter, Kohlbacher and Wanke (2013) Elucidating the evolutionary conserved DNA-binding specificities of WRKY transcription factors by molecular dynamics and in vitro binding assays. Nucleic Acids Research. 41(21). 9764-9778 Additionally, contrary to early reports, both WRKY domains of group I family members can bind DNA.Brand, Fischer, Harter, Kohlbacher and Wanke (2013) Elucidating the evolutionary conserved DNA-binding specificities of WRKY transcription factors by molecular dynamics and in vitro binding assays. Nucleic Acids Research. 41(21). 9764-9778 Implications of these results are still being resolved.

The EFI is developing an integrated sequence-structure based strategy for functional assignment by predicting the substrate specificities of unknown members of mechanistically diverse enzyme superfamilies. The approach leverages conserved features within a given superfamily such as known chemistry, identity of active site functional groups, and composition of specificity-determining residues, motifs, or structures to predict function but relies on multidisciplinary expertise to streamline, refine, and test the predictions. The integrated sequence-strategy under development will be generally applicable to deciphering the ligand specificities of any functionally unknown protein.

These six methyltransferase specificities (SpnD39IIIA-F) result in six differentiated cell types in a pneumococcal population. A potential phasevarion controlled by a Type IIG R-M system has been recently described in the human gastric pathogen Campylobacter jejuni.

This gene is different from the GAL3ST3 gene located on chromosome 11, which has also been referred to as GAL3ST2 and encodes a related enzyme with distinct tissue distribution and substrate specificities, compared to galactose-3-O-sulfotransferase 2.

The Greco-Iberian alphabet is a direct adaptation of an Ionic variant of a Greek alphabet to the specificities of the Iberian language. The inscriptions that use the Greco-Iberian alphabet have been found mainly in Alicante and Murcia.

Sulfotransferase enzymes catalyze the sulfate conjugation of many hormones, neurotransmitters, drugs, and xenobiotic compounds. These cytosolic enzymes are different in their tissue distributions and substrate specificities. The gene structure (number and length of exons) is similar among family members.

Medulla is also important for implementation of self tolerance, which is mediated by CD4+CD25+Foxp3 nTreg cells. Foxp3 Treg development is supported by mTECs during negative selection, when thymocytes have TCR specificities with intermediate affinity for self antigens.

Viruses can encode proteins with sequence homology to cyclins. One much-studied example is K-cyclin (or v-cyclin) from Kaposi sarcoma herpes virus (see Kaposi’s sarcoma), which activates CDK6. Viral cyclin-CDK complexes have different substrate specificities and regulation sensitivities.

Each has its > own history, its specificities, its similarities, its demands, its > struggles, its successes. If humanity wants to survive and improve, its only > hope resides in these pockets made up of the excluded, the left-for-dead, > the 'disposable'.

Extrapolation of this data to other species requires caution – individual species may require different flanking sequences, as binding specificities of scavenger receptors vary across species. Additionally, species such as ruminants may be insensitive to immunostimulatory sequences due to their large gastrointestinal load.

GalNAc-Ts have different, but overlapping, substrate specificities and patterns of expression. The encoded protein is capable of glycosylating fibronectin peptide in vitro and is expressed in a fibroblast cell line, indicating that it may be involved in the synthesis of oncofetal fibronectin.

The specificities were 95%, 72%, and 73% for PAMG-1, fFN and CL, respectively. The NPVs were 96%, 87%, and 89% for PAMG-1, fFN and CL, respectively. The PPVs were 76%, 29%, and 30% for PAMG-1, fFN and CL, respectively.

The frequent association of anti-LKM-1 antibodies and hepatitis C virus (HCV) infections and the probable existence of an infectious and autoimmune form of anti-LKM-1-associated hepatitis, requiring different therapeutical strategies, necessitates the exact determination of anti-LKM-1 specificities.

Picking a fish stock is trying to compensate for the regular stocking of, which in turn leads to the question of local populations gene pool, because of the autochthonous specificities, even in the source area of the flows of the Vrbanja river and its tributaries.

These compounds are primarily used in scientific research, as their high binding affinity for monoamine transporters, and the wide range of radiolabelled phenyltropane compounds available with different binding specificities makes them very useful for mapping the distribution of the various monoamine transporters in the brain.

Along scFv and Fab fragments, diabodies or bispecific recombinant antibodies are the third major format. Bispecific antibodies combine two different antigen binding specificities within one molecule. The bispecific antibodies are used to crosslink the target molecules with two different cells and mediate direct cytotoxicity.

The book describes the history and development of languages of the world, the specificities and commonalities of languages, ancient language writing and decoding, the development and spread of language families and individual languages, as well as the development and history of auxiliary languages like Esperanto and Interlingua.

Two main strategies have been described to engineer the scFv fragments. The first one is the so- called non-colinear approach. It works on the principle of heterodimerization of two chains. Non-colinear approach leads to production of diabodies and recombinant antibodies, which combine two specificities.

It has been proposed that the main mechanism of evolution in phage lysins is the exchange of modular units, a process by which different catalytic and cell-binding domains have been swapped between lysins, which would have resulted in new combinations of both bacterial binding and catalytic specificities.

For the Homeric hero, nothing is as he remembered; everything has changed. His world is literally covered in mist. It's a fraught experience, this double gesture of identification and alienation. Finally, these works point to something far more universal than the specificities of national politics or geo-historical coordinates.

Nearly all scientific computations involve linear algebra. Consequently, linear algebra algorithms have been highly optimized. BLAS and LAPACK are the best known implementations. For improving efficiency, some of them configure the algorithms automatically, at run time, for adapting them to the specificities of the computer (cache size, number of available cores, ...).

The antibodies will attack the self-antigens and the tissues harboring them by activating various mechanisms like the complement activation and antibody-dependent cell-mediated cytotoxicity. Hence, wider the range of antibody-specificities, greater the chance that one or the other will react against self-antigens (native molecules of the body).

Orbiviruses primarily cause diseases in animals. The different Orbivirus species have different host specificities. Orbiviruses are vector-borne pathogens transmitted between vertebrate hosts by vectors such as mosquitoes, midges, gnats, sandflies, and ticks. Bluetongue virus (BTV) is an Orbivirus that causes bluetongue disease in sheep, cattle, goats, and wild ungulates.

This typing is designated as Dw types. Serotyped DR1 has cellularly defined as either of Dw1 or of Dw20 and so on for other serotyped DRs. Table shows associated cellular specificities for DR alleles. However, cellular typing has inconsistency in the reaction between cellular-type individuals, sometimes resulting differently from predicted.

Its specificities: to broadcast Japanese animation aiming at 15 to 25-year-old core target group (although the audience of the channel is in fact much broader going from 12 to 35 years old). GONG Television: GONG launched its first 24/7 Pay TV version on 28 April 2009 in France.

There are two other brain-specific angiogenesis inhibitor genes, designated BAI2 and BAI3 which along with BAI1 have similar tissue specificities and structures, however only BAI1 is transcriptionally regulated by p53. BAI1 is postulated to be a member of the secretin receptor family, an inhibitor of angiogenesis and a growth suppressor of glioblastomas.

In ideal circumstances, influenza virus neuraminidase (NA) should act on the same type of receptor the virus hemagglutinin (HA) binds to, a phenomenon that does not always happen. It is not quite clear how the virus manages to function when there is no close match between the specificities of NA and HA.

Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product inactivates ERK1 and ERK2, is predominantly expressed in hematopoietic tissues, and is localized in the nucleus.

Sulfotransferase 1C4 is an enzyme that in humans is encoded by the SULT1C4 gene. Sulfotransferase enzymes catalyze the sulfate conjugation of many hormones, neurotransmitters, drugs, and xenobiotic compounds. These cytosolic enzymes are different in their tissue distributions and substrate specificities. The gene structure (number and length of exons) is similar among family members.

Due to the distance (Sombor is away from Belgrade) and the specificities of the waste treatment, only one truck weekly will transport the bones, so it is planned for the proncess to lasts for several months. The transport was intensified and the bones were completely removed by the end of August 2019.

The C-terminus helps bind acetyl CoA and differs among NATs including prokaryotic homologues. NAT1 and NAT2 have different but overlapping substrate specificities. Human NAT1 preferentially acetylates 4-aminobenzoic acid (PABA), 4 amino salicylic acid, sulfamethoxazole, and sulfanilamide. Human NAT2 preferentially acetylates isoniazid (treatment for tuberculosis), hydralazine, procainamide, dapsone, aminoglutethimide, and sulfamethazine.

Containment continued to grow and suppression work began in impacted areas, including on Coffee Pot Rd. On the afternoon of August 30, a storm generated wind gusts of 40 MPH, resulting in crews being pulled from fire lines. The fire was determined to be human caused, with further investigation required to determine specificities.

Sulfotransferase 1A1 is an enzyme that in humans is encoded by the SULT1A1 gene. Sulfotransferase enzymes catalyze the sulfate conjugation of many hormones, neurotransmitters, drugs, and xenobiotic compounds. These cytosolic enzymes are different in their tissue distributions and substrate specificities. The gene structure (number and length of exons) is similar among family members.

Estrogen sulfotransferase is an enzyme that in humans is encoded by the SULT1E1 gene. Sulfotransferase enzymes catalyze the sulfate conjugation of many hormones, neurotransmitters, drugs, and xenobiotic compounds. These cytosolic enzymes are different in their tissue distributions and substrate specificities. The gene structure (number and length of exons) is similar among family members.

Sulfotransferase 1A2 is an enzyme that in humans is encoded by the SULT1A2 gene. Sulfotransferase enzymes catalyze the sulfate conjugation of many hormones, neurotransmitters, drugs, and xenobiotic compounds. These cytosolic enzymes are different in their tissue distributions and substrate specificities. The gene structure (number and length of exons) is similar among family members.

Many participate in phase I metabolism of xenobiotics such as toxins or drugs; the resulting carboxylates are then conjugated by other enzymes to increase solubility and eventually excreted. The carboxylesterase family of evolutionarily related proteins (those with clear sequence homology to each other) includes a number of proteins with different substrate specificities, such as acetylcholinesterases.

World Health Organization. WHO/MAL/83.999, WHO/MAL/83.873M. P. falciparum is one of the four main protozoan parasites that cause malaria and is one of the leading causes of malaria deaths. This species complex is of high medical importance for malaria control, in view of the biological specificities of the members of this complex.

The study of human populations has been at the forefront of genomic and clinical research since the Human Genome Project (HGP) was completed. Projects similar to HGDP are the 1000 Genomes Project and the HapMap Project. Each has its own specificities and each has been used by scientists to a large extent for overlapping purposes.

Sulfotransferase 1A3/1A4 is an enzyme that in humans is encoded by the SULT1A3 gene. Sulfotransferase enzymes catalyze the sulfate conjugation of many hormones, neurotransmitters, drugs, and xenobiotic compounds. These cytosolic enzymes are different in their tissue distributions and substrate specificities. The gene structure (number and length of exons) is similar among family members.

In the town, some basins (fountains) cut in the stone are very famous. Indeed, in 1999, most of the basins of the township were renovated. Ovens of different hamlets are also significant and have their specificities. The walking tour "ovens and fountains" was created specially to visit most of the ovens and fountains of the township.

The PTS Fructose-Mannitol (Fru) Family (TC# 4.A.2) is a large and complex family that is part of the PTS-GFL superfamily. It includes several sequenced fructose, mannose and mannitol-specific porters, as well as several putative PTS porters of unknown specificities. The fructose porters of this family phosphorylate fructose on the 1-position.

G. intestinalis contains two functionally equivalent nuclei that are inherited independently during mitosis. In the giardial cyst these nuclei fuse (karyogamy) and undergo homologous recombination facilitated by meiosis gene homologs. The recombination associated with karyogamy may primarily function to repair DNA damage. G. intestinalis is divided into eight assemblages based on host specificities and genetic divergence of marker genes.

Sulfotransferase family cytosolic 1B member 1 is an enzyme that in humans is encoded by the SULT1B1 gene. Sulfotransferase enzymes catalyze the sulfate conjugation of many hormones, neurotransmitters, drugs, and xenobiotic compounds. These cytosolic enzymes are different in their tissue distributions and substrate specificities. The gene structure (number and length of exons) is similar among family members.

Governance would also appear to be a sensitive issue for French mutualists, who have been faced with significant successive changes to their regulations (in 2002, 2003 and then again in 2005) and so have had to respond to the continual challenge regarding the recognition of their statute and of their specificities by adapting to these changes.

The couple also offered a Hawaiian Hula class taught by the dance instructor Kulamanu, as well as a class taught by Misha Ito that emphasized specificities of the technique to Japanese sword dancing. Outside of movement classes, the school had lectures, music classes, the art of dyeing and the treatment of fabrics, and libraries to study for these courses.

The majority of bacterial pathogens exploit specific adhesion to host cells as their main virulence factor. "A large number of bacterial adhesins with individual receptor specificities have been identified." Many bacterial pathogens are able to express an array of different adhesins. Expression of these adhesins at different phases during infection play the most important role in adhesion based virulence.

The Amino Acid/Auxin Permease (AAAP) Family (TC# 2.A.18) is a family of secondary carrier proteins, a member of the APC Superfamily that includes hundreds of proteins from plants, animals, fungi and lower eukaryotes. Six AAAPs in A. thaliana are well characterized and transport neutral and charged amino acids with varying specificities and affinities.

Inca architecture is strongly characterized by its use of the natural environment. The Inca managed to seamlessly merge their architecture into the surrounding land and its specificities. At its peak, the Inca Empire spanned from Ecuador to Chile. Yet despite geographic variances, Inca architecture remained consistent in its ability to visually blend the built and natural environment.

Lefebvre JL, Zhang Y, MeisterM, Wang X, Sanes JR. 2008. γ-Protocadherins regulate neuronal survival but are dispensable for circuit formation in retina. Development 135:4141–51 Isoform- specific homophilic recognition Compelling evidence for discrete binding specificities of different clustered Pcdhs isoforms was uncovered in 2010 by Schreiner & Weiner, who verified that Pcdhs promote isoform-specific homophilic recognition.

Sulfotransferase enzymes catalyze the sulfate conjugation of many hormones, neurotransmitters, drugs, and xenobiotic compounds. These cytosolic enzymes are different in their tissue distributions and substrate specificities. The gene structure (number and length of exons) is similar among family members. This gene is primarily expressed in liver and adrenal tissues where the encoded protein sulfonates steroids and bile acids.

The best-characterised variant of this of enzyme is Bacillus subtilis lichenase, which is used as a molecular biology tool in determining the structure of mixed-linkage glucans. This variant cleaves (1,4) bonds that immediately follow a (1,3) bond. Other lichenases have different specificities, for example Aspergillus japonicus lichenase cleaves (1,4) bonds that immediately precede a (1,3) bond.

It looked like a "railroad car", without any specificities. In the 1990s it was relocated to the neighborhood of Ušće. At the time, Ada wasn't that well connected to the rest of the city which gave this venues a certain aura of exclusivity. Splav "Sara" was the very first venue in Belgrade with solely electronic music.

1648-1650, voce a cura di C. Zambelli. The original rule was revised in 1872 by Darowska, which highlighted the specificities of the congregation. Pius IX granted the Sisters of the Immaculate Conception a decretum laudis on May 22, 1863 and approved the congregation on July 29, 1874. The founder was beatified by John Paul II in 1996.

PcTx1 and APETx2, like mambalgins, are ASIC inhibitors, albeit with different subtype specificities; MitTx is an activator associated with causing pain in vivo. The four proteins have no detectable sequence similarity. The natural function of ASIC-inhibiting analgesic peptides is unclear, as all are produced by predator animals yet have no known toxic effects on the corresponding prey.

Sulfotransferase family cytosolic 2B member 1 is an enzyme that in humans is encoded by the SULT2B1 gene. Sulfotransferase enzymes catalyze the sulfate conjugation of many hormones, neurotransmitters, drugs, and xenobiotic chemical compounds. These cytosolic enzymes are different in their tissue distributions and substrate specificities. The gene structure (number and length of exons) is similar among family members.

This concept is related to multi-compartmentalization. Any drugs within an organism will act as a solute and the organism's tissues will act as solvents. The differing specificities of different tissues will give rise to different concentrations of the drug within each group. Therefore, the chemical characteristics of a drug will determine its distribution within an organism.

Some serotyping antibodies proved to be poor, with broad specificities, and new serotypes were found that identified a smaller set of antigens more precisely. These broad antigen groups, like A9 and B5, were subdivided into "split" antigen groups, A23 & A24 and B51 & B52, respectively. As the HL-A serotyping developed, so did identification of new antigens.

Housing in Portugal is generally similar to housing in the rest of Europe. However, some specificities exist. Portugal has the highest rate of rural population in Western Europe, which means that roughly a third of the Portuguese families live in farms or properties outside urban areas. Another characteristic is that most of the urban population is actually suburban.

HTC EVO 4G+ (codenamed HTC Rider) is an Android smartphone developed by HTC Corporation, released exclusively in South Korea through Korea Telecom in 2011.A variation of HTC Evo 3D, the device is distinguished by its single 8 MP rear camera, which means all the 3D specificities are gone, and is running on Korea Telecom's WiBro network.

Vasoactive intestinal peptide (VIP) and pituitary adenylate cyclase activating polypeptide (PACAP) are homologous peptides that function as neurotransmitters and neuroendocrine hormones. While the receptors for VIP (VIRP 1 and 2) and PACAP (ADCYAP1R1) share homology, they differ in their substrate specificities and expression patterns. VIPR2 transduction results in upregulation of adenylate cyclase activity. Furthermore, VIPR2 mediates the anti-inflammatory effects of VIP.

With just one exception, the HMTases belong to SET family that can be classified according to the sequences surrounding the SET domain. Structural studies on the human SET7/9, a mono- methylase, have revealed the molecular basis for the specificity of the enzyme for the histone-target and the roles of the invariant residues in the SET domain in determining the methylation specificities.

Lectins is a generic name for proteins with carbohydrate-recognizing domains (CRD). Although it became almost synonymous with glycan-binding proteins, it does not include antibodies which also belong to the class. Lectins found in plants and fungi cells have been extensively used in research as a tool to detect, purify, and analyze glycans. However, useful lectins usually have sub- optimal specificities.

NCS1 proteins are H+/Na+ symporters specific for the uptake of purines, pyrimidines and related metabolites. Krypotou et al. 2015 studied the origin, diversification and substrate specificities of fungal NCS1 transporters, suggesting that the two fungal NCS1 subfamilies, Fur and Fcy, and plant homologues, originated through independent horizontal transfers from prokaryotes. Expansion by gene duplication led to functional diversification of fungal NCS1 porters.

Actin exists in two states in the axonal and dendritic processes: globular or G-actin and filament/filamentous or F-actin. G-actin are the monomer building blocks that assemble via weak noncovalent interactions to form F-actin. F-actin is a two-stranded asymmetrical helical polymer. The asymmetrical quality of F-actin allows for different binding specificities at each end.

The Plant Cell Online. 15(9). 2076-2092 Since then, WRKYs have been found to bind a more generic GAC core cis-element with flanking sequences dictating DNA-protein interactions.Brand, Fischer, Harter, Kohlbacher and Wanke (2013) Elucidating the evolutionary conserved DNA-binding specificities of WRKY transcription factors by molecular dynamics and in vitro binding assays. Nucleic Acids Research. 41(21).

The workshops of the OECD (Organization for Economic Cooperation and Development) let 130 countries participate in exchanging ideas in the organization for the rural development. Pierre Guerry, consultant of this workshop as marketing expert, proposed an approach of ecotourism to promote the local products and the territorial specificities in the supranational level. Afterward, the approach was suggested to the institutional organizations.

Several single-nucleotide polymorphisms have been described in M-ficolin in humans, with effect on ligand-binding ability and serum levels. Historically, the larger fragment of C2 was named C2a, but it is now referred to as C2b. In invertebrates without an adaptive immune system, ficolins are expanded and their binding specificities diversified to compensate for the lack of pathogen-specific recognition molecules.

Integrins are heterodimers composed of alpha and beta subunits, that are noncovalently associated transmembrane glycoprotein receptors. Different combinations of alpha and beta polypeptides form complexes that vary in their ligand-binding specificities. Integrins mediate cell-matrix or cell-cell adhesion, and transduced signals that regulate gene expression and cell growth. This gene encodes the integrin beta 4 subunit, a receptor for the laminins.

All three SHC1 proteins share the same domain arrangement consisting of an N-terminal phosphotyrosine- binding(PTB) domain and a C-terminal Src-homology2(SH2) domain. Both of the domains for the three proteins can bind to tyrosine-phosphorylated proteins but they are different in their phosphopeptide-binding specificities. P66SHC is characterized by having an additional N-terminal CH2 domain.

These differing tissue specificities cause the differing clinical manifestations of the various forms of leishmaniasis. (5,6) Sandflies become infected during blood meals on infected hosts when they ingest macrophages infected with amastigotes. (7) In the sandfly's midgut, the parasites differentiate into promastigotes, (8) which multiply, differentiate into metacyclic promastigotes, and migrate to the proboscis. The genomes of three Leishmania species (L.

Sulfotransferase enzymes catalyze the sulfate conjugation of many hormones, neurotransmitters, drugs, and xenobiotic compounds. These cytosolic enzymes are different in their tissue distributions and substrate specificities. The gene structure (number and length of exons) is similar among family members. This gene encodes a protein that belongs to the SULT1 subfamily, responsible for transferring a sulfo moiety from PAPS to phenol- containing compounds.

Crystals of a DNase protein. A deoxyribonuclease (DNase, for short) is an enzyme that catalyzes the hydrolytic cleavage of phosphodiester linkages in the DNA backbone, thus degrading DNA. Deoxyribonucleases are one type of nuclease, a generic term for enzymes capable of hydrolyzing phosphodiester bonds that link nucleotides. A wide variety of deoxyribonucleases are known, which differ in their substrate specificities, chemical mechanisms, and biological functions.

In this regard, successful routines application depends on the context specificities where there exist complementarities between routines and context. It is possible to alleviate specificity but not to neutralize it through standardisation. Routines can be transferred to various contexts in a limited manner indicating that they can reflect local optimum solutions but not global best solutions. History shapes routines and they are dependent on the path.

Published by Leeds University, 1995. Reprinted in: Drawing Papers, nº 24, 2001. that has established a feminine gaze and has articulated its differences from the phallic gaze and its relation to feminine as well as maternal specificities and potentialities of "coemergence", offering a critique of Sigmund Freud's and Jacques Lacan's psychoanalysis, is extensively used in analysis of filmsGriselda Pollock, After-effects - After-images. Manchester University Press, 2013.

Brennan, J., Mahon, G., Mager, D., Jefferies, W. and Takei, F., 1996. Recognition of class I major histocompatibility complex molecules by Ly-49: specificities and domain interactions. The Journal of Experimental Medicine, 183(4), pp.1553-1559. Takei, F., Brennan, J. and Mager, D., 1997. The Ly-49 family: genes, proteins and recognition of class I MHC. Immunological Reviews, 155(1), pp.67-77.

EHEST is also the European component of the International Helicopter Safety Team (IHST). EHEST features representatives of manufacturers, operators, research organisations, regulators, accident investigators and military from across Europe. To address the specificities of the safety of helicopter operations in Europe, the European members of the IHST have established EHEST in November 2006. The European Helicopter Safety Analysis Team (EHSAT) is the safety team of EHEST.

The results of some studies are generated mostly from the histochemical analysis of tumor specimens using JADE1 antibody with uncharacterized specificities towards JADE1 in general, and JADE1S or JADE1L in particular. Results of study using in silico microarray algorithm analysis shows, that PHF17 mRNA may play a role in the development of pancreatic cancer. These promising lines of investigations require further controls and additional assessments.

In 1992, her work on proteases led to the identification of the first caspase, caspase-1/Interleukin-1 converting enzyme (ICE). She determined that ICE was the cysteine protease responsible for IL-1β processing in monocytes. Thornberry also developed a novel method for analyzing protease specificities in combinatorial libraries of positional scanning substrates. Her work has led to the broader study of proteases in apoptosis.

Catechol dioxygenases are metalloprotein enzymes that carry out the oxidative cleavage of catechols. This class of enzymes incorporate dioxygen into the substrate (biochemistry). Catechol dioxygenases belong to the class of oxidoreductases and have several different substrate specificities, including catechol 1,2-dioxygenase (), catechol 2,3-dioxygenase (), and protocatechuate 3,4-dioxygenase (). The active site of catechol dioxygenases most frequently contains iron, but manganese-containing forms are also known.

Selection boards are partially renewed each year. They have many international members and international character is one of the specificities of the IUF. The use of top international experts avoids any risk of cooptation and guarantees the high quality of appointments to the IUF. Since 2009, the jury is officially made up for more than half of foreign scientists known for their international reputation.

Muller-Roeber B, Pical C. Inositol Phospholipid Metabolism in Arabidopsis. Characterized and Putative Isoforms of Inositol Phospholipid Kinase and Phosphoinositide-Specific Phospholipase C. Plant Physiol 2002 130:22–46 PIPKs are today divided into three groups, type I, II and III that share significant sequence homology but differ in the substrate specificities, subcellular localisations and functions.Anderson RA, Boronenkov IV, Doughman SD, Kunz J, Loijens JC .

We are on the brink of a convergence of high-throughput technologies and genomic theory that is allowing researchers to start mapping these interactions on a genome-wide scale. Only recently has a complete survey of DNA-binding specificities been attempted for a large family of DNA-binding domains. B1H is just one emerging technique among many that is useful for studying protein–DNA interactions.

Problems encountered in this work provoked him to develop analysis methods addressing the specificities of structure and meaning in various types popular music, e.g. the “Kojak thesis” (1979) and the reception tests at the basis of his book Ten Little Title Tunes (2003). Tagg was at this time also songwriter and keyboard player in the left-wing “rock cabaret” band Röda Kapellet (1972–76).

There are three aminoacylation specificities, valine, histidine and tyrosine. For example, valine binds to the tRNA-like structure of the turnip yellow mosaic virus genome whilst tyrosine binds to the tRNA-like structure of the barley stripe mosaic virus genome. tRNA-like structures which lack the 3' termini lack complete or partial tRNA mimicry. tRNA-like structures are required for RNA encapsulation and increase RNA stability.

The alpha chain is approximately 33-35 kDa. It is encoded by 5 exons, exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane and the cytoplasmic tail. Within the DP molecule both the alpha chain and the beta chain contain the polymorphisms specifying the peptide binding specificities, resulting in up to 4 different molecules.

IAVs binds to host cells using the HA protein. These proteins recognise sialic acid that reside on the terminal regions of external glycoproteins on host cell membranes. However, HA proteins have different specificities for isomers of sialic acid depending on which species the IAV is adapted for. IAVs adapted for birds recognise α2-3 sialic acid isomers whereas human adapted IAV HAs bind to α2-6 isomers.

Gene duplications have played a crucial role in the evolution of species. This applies particularly to transcription factors. Once they occur as duplicates, accumulated mutations encoding for one copy can take place without negatively affecting the regulation of downstream targets. However, changes of the DNA binding specificities of the single-copy LEAFY transcription factor, which occurs in most land plants, have recently been elucidated.

The festivity consists of getting together around the fire and socializing. Each particular celebration, however, has its own specificities which reflect traditions of the local community, and other local factors. In Serbia, Montenegro and North Macedonia Christmas is celebrated on January 7. This is a result of their Eastern Orthodox churches marking Christmas Day based on the Julian calendar, which is now 13 days behind the internationally used Gregorian calendar.

Its offices, as well as the showroom and store, were on the main street in Perugia, Corso Vannucci, at number 8. It was managed by the Marchioness and by Carolina Amari who produced an advertising brochure in several languages, outining the specificities of each school and of the embroideries produced there. to which the "Scuola di ricami Ranieri di Sorbello" became affiliated and which was active until 1929.

Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product is the human ortholog of the Saccharomyces cerevisiae YVH1 protein tyrosine phosphatase. It is localized predominantly in the nucleus, and is novel in that it contains, and is regulated by a zinc finger domain.

Roe deer and wild boar are being bred in the facility. The section of the forest, called Dugi Rt, was declared a protected area by the city on 29 November 2013. It is protected for the both biological (forest complex) but also for the geomorphological and hudrological values. The specificities of the Dugi Rt ridge and the bed of the Sremačka river helped the development of the diverse flora and fauna.

To enhance this effect, FokI nucleases have been engineered that can only function as heterodimers. Several approaches are used to design specific zinc finger nucleases for the chosen sequences. The most widespread involves combining zinc-finger units with known specificities (modular assembly). Various selection techniques, using bacteria, yeast or mammal cells have been developed to identify the combinations that offer the best specificity and the best cell tolerance.

The alpha chain contains 5 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular protein domains, exon 4 encodes the transmembrane domain and the cytoplasmic tail. Within the DQ molecule both the alpha chain and the beta chain contain the polymorphisms specifying the peptide binding specificities, resulting in up to 4 different molecules. Typing for these polymorphisms is routinely done for bone marrow transplantation.

Though the majority of the overall structure of the aldolase enzyme is conserved amongst the three isozymes, four regions of the generic aldolase enzyme have been identified to be highly variable among isozymes. Such regions have been denoted isozyme-specific regions (ISR1-4). These regions are thought to give isozymes their specificities and structural differences. ISRs 1-3 are all found in exon 3 of the ALDOB gene.

Glycosylation is an important parameter in the optimization of many glycoprotein-based drugs such as monoclonal antibodies. Glycosylation also underpins the ABO blood group system. It is the presence or absence of glycosyltransferases which dictates which blood group antigens are presented and hence what antibody specificities are exhibited. This immunological role may well have driven the diversification of glycan heterogeneity and creates a barrier to zoonotic transmission of viruses.

Although most C2 domains interact with the membrane (phospholipids) in a Ca2+-dependent manner, some C2 domains can interact with the membrane without binding to Ca2+. Similarly, C2 domains have been evolved to have different specificities for lipids. Many C2 domains such as synaptotagmin C2A, bind to anionic phospholipids (PS or PIP2 containing phospholipids). However, other C2 domains such as cPLA2-α C2 domain bind to zwitterionic lipids (e.g. PC).

Both are quite similar with an approximately 63% amino acid identity, but show slightly different protein substrate specificities. TPST is a prevalent enzyme, found in many multicellular eukaryotes including mammals, most vertebrates, and a number of invertebrate species as well, including Drosophila melanogaster. Its importance can be further demonstrated by the fact as much as 1% of all secreted and membrane tyrosine residues are found to be sulfated.

CSLI was founded in Austria in 2006 as a subsidiary of the LHW (Lazarus Hilfswerk), which was founded in 1973. It is an international organization with headquarters in Austria, in Vienna, and is recognized by the authorities of that country with registration no. 023914681 (Austrian central register). In a short time the CSLI expands in Europe and in many other countries, in each of which develops projects with local specificities.

As the movement lost some of its vigor, intellectuals started to debate just what could be considered Chicano art. This debate claimed that art could not be mainstream in any way and must go against the grain of classic European artistic notions. Nobody ever came to a conclusion on the specificities of Chicano art and most forms that champion culture, community, or Meso-American ties are considered forms of Chicano art.

The beta chain is approximately 26–28 kDa. It is encoded by 6 exons, exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and exon 5 encodes the cytoplasmic tail. Within the DR molecule the beta chain contains all the polymorphisms specifying the peptide binding specificities. Typing for these polymorphisms is routinely done for bone marrow and kidney transplantation.

Passive memory is usually short-term, lasting between a few days and several months. Newborn infants have had no prior exposure to microbes and are particularly vulnerable to infection. Several layers of passive protection are provided by the mother. In utero, maternal IgG is transported directly across the placenta, so that, at birth, human babies have high levels of antibodies, with the same range of antigen specificities as their mother.

This brings us back to step 1: measure consumption. One of the specificities of M&T; is that it is an ongoing process, requiring constant feedback in order to consistently improve performance. Once the targets are set and the desired measures are implemented, repeating the procedure from the start ensures that the managers are aware of the success or failure of the measures, and can then decide on further action.

Peroxisomal beta-oxidation of fatty acids, originally described by Lazarow and de Duve (1976), is catalyzed by 3 enzymes: acyl-CoA oxidase (see, e.g., ACOX1, MIM 609751); the 'D-bifunctional enzyme,' with enoyl-CoA hydratase and D-3-hydroxyacyl-CoA dehydrogenase activity, and 3-ketoacyl-CoA thiolase (MIM 604054). See also the L-bifunctional peroxisomal protein (EHHADH; MIM 607037). The D- and L-bifunctional proteins have different substrate specificities.

Proteins of the DASS family are divided into two groups of transporters with distinct anion specificities: the Na+-sulfate (NaS) cotransporters and the Na+-carboxylate (NaC) cotransporters. Mammalian members of this family are: SLC13A1 (NaS1), SLC13A2 (NaC1), SLC13A3 (NaC3), SLC13A4 (NaS2) and SLC13A5 (NaC2). DASS family proteins encode plasma membrane polypeptides with 8-13 putative transmembrane domains, and are expressed in a variety of tissues. They are all Na+-coupled symporters.

In this arrangement there were cells that were 'blank' or had new specificities, these new antigens were called "W" antigens, and as they were reassigned to new groups, for example "A" serotypes, they became Aw or Bw antigens. It was found that some antigens that behaved like A and B antigens but could be excluded based on '2-type max' exclusion. Thus a new group, "C" was created.

Queuine () (Q) is a hypermodified nucleobase found in the first (or wobble) position of the anticodon of tRNAs specific for Asn, Asp, His, and Tyr, in most eukaryotes and prokaryotes. The nucleoside of queuine is queuosine. Queuine is not found in the tRNA of archaea; however, a related 7-deazaguanine derivative, the nucleoside of which is archaeosine, occurs in different tRNA position, the dihydrouridine loop, and in tRNAs with more specificities.

Lectin histochemistry of fish muscles infected by a myxozoan Lectins from legume plants, such as PHA or concanavalin A, have been used widely as model systems to understand the molecular basis of how proteins recognize carbohydrates, because they are relatively easy to obtain and have a wide variety of sugar specificities. The many crystal structures of legume lectins have led to a detailed insight of the atomic interactions between carbohydrates and proteins.

Each region possesses its own specificities, thus contributing to the national culture and to the legacy of civilization. Morocco has set among its top priorities the protection of its diverse legacy and the preservation of its cultural heritage. Culturally speaking, Morocco has always been successful in combining its Berber, Jewish and Arabic cultural heritage with external influences such as the French and the Spanish and, during the last decades, the Anglo-American lifestyles.

In 2009, with several organizations led by Kimirina corporation, Diane Rodriguez gave life to the first comics or preventive character transgender, which she called "Victor Victoria".AG Magazine , "Diane Marie Armoire and Exclusion to Militancy and action - In Spanish". Retrieved August 10, 2013. The magazine was intended to give the necessary attention to the transgender population in the different aspects of everyday life such as health, education, employment, violence, including trans specificities.

The European Commission is sensitive to the issue which was addressed in a speech by the EU's High Representative/Vice-President Federica Mogherini at the European Parliament Plenary Session on the Western Balkan Strategy: " shared, unequivocal, concrete perspective for European Union integration for each and every one of the six partners. Each at its own pace, with its own specificities and under different conditions, but the direction is clear and is one ".

There are many different types of bacterial 60 kDa transmembrane receptors, which share similar topology and signalling mechanisms. They possess three domains: a periplasmic ligand-binding domain, two transmembrane segments, and a cytoplasmic domain. The structure of the ligand-binding domain comprises a closed or partly opened, four-helical bundle with a left-handed twist. The difference in the sequence of the ligand-binding domain between receptors reflects the different ligand specificities.

Protein-arginine deiminase type-2 is an enzyme that in humans is encoded by the PADI2 gene. This gene encodes a member of the peptidyl arginine deiminase family of enzymes, which catalyze the post-translational deimination of proteins by converting arginine residues into citrullines in the presence of calcium ions. The family members have distinct substrate specificities and tissue-specific expression patterns. The type II enzyme is the most widely expressed family member.

TASER devices are used by the French National Police and Gendarmerie. In September 2008, they were made available to local police by a government decree, but in September 2009, the Council of State reversed the decision judging that the specificities of the weapon required a stricter regulation and control. However, since the murder of a policewoman on duty, the TASER CEW has been in use again by local police forces since 2010.

The catabolite repression in this case is achieved through the utilization of phosphotransferase system. An important enzyme from the phosphotransferase system called Enzyme II A (EIIA) plays a central role in this mechanism. There are different catabolite-specific EIIA in a single cell, even though different bacterial groups have specificities to different sets of catabolites. In enteric bacteria one of the EIIA enzymes in their set is specific for glucose transport only.

Brand, Fischer, Harter, Kohlbacher and Wanke (2013) Elucidating the evolutionary conserved DNA-binding specificities of WRKY transcription factors by molecular dynamics and in vitro binding assays. Nucleic Acids Research. 41(21). 9764-9778 The original WRKY protein domain has been proposed to have arisen from the GCM1 and FLYWCH zinc finger factors.Babu, Iyer, Balaji and Aravind (2006) The natural history of the WRKY–GCM1 zinc fingers and the relationship between transcription factors and transposons.

B1H system provides a tool in our arsenal for identifying the DNA-binding specificities of transcription factors and thus predicting their target genes and genomic DNA regulatory elements. It also allows for examination of the effects of protein–protein interactions on DNA binding, which may further guide the prediction of cis regulatory modules based on binding-site clustering. Moreover, the B1H selection system has implications for the predicting regulatory roles of previously uncharacterized transcription factors.

Galactokinases across different species display a great diversity of substrate specificities. E. coli galactokinase can also phosphorylate 2-deoxy-D-galactose, 2-amino-deoxy-D- galactose, 3-deoxy-D-galactose and D-fucose. The enzyme cannot tolerate any C-4 modifications, but changes at the C-2 position of D-galactose do not interfere with enzyme function. Both human and rat galactokinases are also able to successfully phosphorylate 2-deoxy-D-galactose.

The biochemical mechanism that determines product length is not fully characterized. Although the three catalytic β subunits have a common mechanism, they have slightly different substrate specificities, which are considered chymotrypsin-like, trypsin-like, and peptidyl-glutamyl peptide- hydrolyzing (PHGH)-like. These variations in specificity are the result of interatomic contacts with local residues near the active sites of each subunit. Each catalytic β subunit also possesses a conserved lysine residue required for proteolysis.

These three receptors have been renamed as FPR1, FPR2, and FPR3 and found to have very different specificities for the formyl oligopeptides and very different functions that include initiating inflammatory responses to N-formyl peptides released not only by bacteria but also a multiplicity of elements released by host tissues; dampening and resolving inflammatory responses; and perhaps contributing to the development of certain neurological cancers and an array of neurological diseases Amyloid-based diseases.

The linker is rich in glycine, which gives it more flexibility, and serine/threonine, which gives it specificity. Two different scFv fragments can be connected together, via a hinge region, to the constant domain of the heavy chain or the constant domain of the light chain. This gives the antibody bispecificity, allowing for the binding specificities of two different antigens. The "knobs-into-holes" format enhances heterodimer formation but doesn't suppress homodimer formation.

The specific activities of sv-LAAOs with various L-amino acids have been explored. Many studies show that a number of sv-LAAOs exhibit a preference for hydrophobic L-amino acids as substrates. For example, results have indicated that most sv-LAAOs demonstrate relatively high specificities toward hydrophobic amino acids such as L-Met, L-Leu, and L-Ile in addition to aromatic amino acids such as L-Phe and L-Trp.

The PDEs have different substrate specificities. Some are cAMP selective hydrolases (PDE 4, -7 and -8), others are cGMP selective hydrolases (PDE 5, -6 and -9) and the rest can hydrolyse both cAMP and cGMP (PDE1, -2, -3, -10 and -11). There is only one gene family coding for the PDE2, which is the PDE2A. Three splice variants have been found, the PDE2A1, PDE2A2 and PDE2A3 (PDE2A2 has only been found in rats).

The RNA-binding Proteins Database (RBPDB) is a biological database of RNA- binding protein specificities that includes experimental observations of RNA- binding sites. The experimental results included are both in vitro and in vivo from primary literature. It includes four metazoan species, which are Homo sapiens, Mus musculus, Drosophila melanogaster, and Caenorhabditis elegans. RNA-binding domains included in this database are RNA recognition motif, K homology, CCCH zinc finger, and more domains.

It is likely that different family members have different substrate specificities, which may overlap. Dus 1 from Saccharomyces cerevisiae (Baker's yeast) acts on pre-tRNA- Phe, while Dus 2 acts on pre-tRNA-Tyr and pre-tRNA-Leu. Dus 1 is active as a single subunit, requiring NADPH or NADH, and is stimulated by the presence of FAD. Some family members may be targeted to the mitochondria and even have a role in mitochondria.

Oturu emphasised the historical roots of these tensions, in the slave trade and African ignorance of the African American experience.Bound: Africans vs African Americans At an African Diaspora Conference in November 2017 she emphasised the opportunities for Africans and African Americans to enlighten each other about the specificities of their respective cultures.The Resurgence and Redefinition of Pan-Africanism, Our Culture Our Identity, The Immigrant Magazine, 15 November 2017. Accessed 17 August 2020.

In an introduction to Beasts of Burden, he writes, "The world is an ocean, in which concepts and theories are like ships which appear and disappear. My works were not composed with the comfort offered by these ships, but written from within the sea and by looking at its vastness." The result is that this story, rooted in specificities of a certain experience, has a resounding universality: it is simply about how life goes on.

Thymoglobulin (manufactured by Sanofi) is an anti-human thymocyte immunoglobulin preparation made of purified polyclonal antibodies derived from rabbits. While these antibodies have a variety of specificities, their main mechanism of immunosuppression is through depletion of T cells. Thymoglobulin is currently approved for clinical use in Europe and the United States for renal allograft rejection, prevention of graft-vs.-host disease, and conditions involving bone marrow failure, including aplastic anemia and has additional off-label uses.

For example, one gene R1 produces one agglutinogen (antigen) Rh1 which is composed of three "factors": rh', Rh(o), and hr' '. The three factors are analogous to C, D, and e respectively in the CDE nomenclature. The d gene does not exist in Wiener's theory, and, in fact, has been proven not to exist at all. In fact, it has recently been proven that there are two connected genes, one of which has multiple specificities, as Wiener theorized.

The beta chain is approximately 26-28 kDa. It is encoded by 6 exons, exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and exon 5 encodes the cytoplasmic tail. Within the DR molecule the beta chain contains all the polymorphisms specifying the peptide binding specificities. Hundreds of DRB1 alleles have been described and typing for these polymorphisms is routinely done for bone marrow and kidney transplantation.

The professors of the Athénée demanded a reform of secondary education and the re-establishment of the academic courses. William II came to the throne in 1840, ending his father's policies of reaction and Germanisation. The Constitution of 1841 allowed a free choice of universities, and laid the foundation for an education policy that took account of the specificities of the country. The coming reform was supported by the liberals, but opposed by the advocates of the Friedemann reform.

As evidenced the artist in an interview, the concepts of identity, cultural specificities are again at the centre of his artistic gesture of re-appropriation. Also, in 2008, the project Contained measures of Land used soil both as a symbol of the territory and competition and conflict. A year later, during his residence at Pointe-Noire, in the Congo, it has collected eight different colours of Earth. Pointe-Noire was colonized by the Portuguese and the French.

The product of this gene is the polyamine oxidase. This enzyme potentially represents a new class of catabolic enzymes in the mammalian polyamine metabolic pathway capable of the efficient oxidation of polyamines. More than five transcript variants encoding four active isoenzymes have been identified for this gene, however, not all variants have been fully described. The characterized isoenzymes have distinctive biochemical characteristics and substrate specificities, suggesting the existence of additional levels of complexity in polyamine catabolism.

Baseline nerve conduction measurements are different for everyone, as they are dependent upon the individual's age, sex, local temperatures, and other anthropometric factors such as hand size and height. It is important to understand the effect of these various factors on the normal values for nerve conduction measurements to aid in identifying abnormal nerve conduction study results. The ability to predict normal values in the context of an individual's anthropometric characteristics increases the sensitivities and specificities of electrodiagnostic procedures.

Board of Education. Educational racism also took other forms throughout history such as the creation of Canadian Indian residential school system in 1831, which forcefully integrated indigenous children into schools aimed at erasing their ethnic, linguistic and cultural specificities in order to assimilate them into a white settler society. Until the last residential school closed in 1996, Canada had an educational system which specifically harmed and targeted indigenous children. An estimated 6,000 children died under that system.

The beta chain is approximately 26-28 kDa. It is encoded by 6 exons, exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and exon 5 encodes the cytoplasmic tail. Within the DR molecule the beta chain contains all the polymorphisms specifying the peptide binding specificities. Hundreds of DRB1 alleles have been described and typing for these polymorphisms is routinely done for bone marrow and kidney transplantation.

As a result of allelic exclusion, all the antigen receptors on an individual lymphocyte will have the same amino acid sequence in the variable domain of the heavy chain protein. As the specificity of the antigen receptor is modulated by the variable domain of the light chain encoded by one of the immunoglobulin light chain loci, the specificities of B cells containing the same heavy chain recombination event can differ according to their light chain recombination event.

Clayton Thyne and Jonathan Powell's dataset of coups defines attempted coups as "illegal and overt attempts by the military or other elites within the state apparatus to unseat the sitting executive." They arrive at this definition by combining common definitions in the existing literature, and removing specificities and ambiguities that exist in many definitions. In looser usage, as in "intelligence coup" or "boardroom coup", the term simply refers to gaining a sudden advantage on a rival.

A paradoxical observation has been the strong association of certain microbial organisms with autoimmune diseases. For example, Klebsiella pneumoniae and coxsackievirus B have been strongly correlated with ankylosing spondylitis and diabetes mellitus type 1, respectively. This has been explained by the tendency of the infecting organism to produce super-antigens that are capable of polyclonal activation of B-lymphocytes, and production of large amounts of antibodies of varying specificities, some of which may be self-reactive (see below).

Heterodimer combinations have been shown to range from 3000 to 25000, and many remain uncharacterized. A technology like SMiLE-seq, which is able to detect these dimeric interactions, is essential to broaden current knowledge and characterization of transcription factor-DNA binding profiles. Additionally, previous technologies have used transcription factor probes in their truncated form, which may reduce their ability to bind and dimerize. SMiLE-seq enables robust identification of DNA binding specificities of full length, previously uncharacterized transcription factors.

Sturgeons are long-lived, late maturing fishes with reproductive cycles that include long migrations, and require specific environmental conditions. They are an ancient species that have survived for millions of years but their future is threatened, due in part to their inherent ancestral characteristics and reproductive specificities. The negative impacts of overfishing, poaching, habitat destruction, and the construction of dams that have altered or blocked their annual migration to ancestral spawning grounds have taken a serious toll.Clover, Charles. 2004.

By sequence analyses of the large oxidoreductase type of enzyme families, he noted that the FAD-binding site is a classical Rossmann fold, but the NADPH binding site has a different consensus sequence that could be responsible for NAD vs. NADP coenzyme specificity. The importance of the motifs he identified was confirmed by re-engineering of coenzyme specificities of different enzymes. Elucidation of the crystal structure of adrenodoxin reductase further verified Israel's identification of the coenzyme binding sites.

According to the Chemoaffinity hypothesis, chemical labels are distributed in a graded fashion across the retina and tectum. This allows each retinal ganglion cell to recognize its proper termination site. Experiments with artificially created compound eyes in Xenopus demonstrate that not only the ganglion cells but also their axons carry these specificities. Axons must be able to communicate with each other to ensure that ones with the same positional tags innervate the same area of the superior colliculus.

Not only was Boris Ginsburg a master of lithography, he also had a perfect command of watercolour technique; he sensed its specificities and masterfully varied intense and serene colours. It gave the artist an opportunity to create, amazing in their execution, watercolours of sea views, piers and ships at anchor. Crimean landscapes always excited Boris’ creative imagination. The biggest attraction for him was the subtle beauty of Koktebel, which had become a magnet for creative circles when Maximillian Voloshyn settled there.

Ecklonia cava is an important food source for snails, such as Littorina brevicula (Philippi) and Haliotis discus (Hannai Ino), and other marine organisms. Interestingly, it has also been shown that Ecklonia cava has a defense mechanism that causes it to be less palatable after having already been attacked by a herbivore, and these defenses are specific to each species of herbivore. Many species of seaweed and other plants have defenses similar to this, but the specificities of each defense have not been pinpointed.

Brain-specific angiogenesis inhibitor 2 is a protein that in humans is encoded by the BAI2 gene. It is a member of the adhesion-GPCR family of receptors. BAI1, a p53-target gene, encodes brain-specific angiogenesis inhibitor, a seven-span transmembrane protein and is thought to be a member of the secretin receptor family. Brain-specific angiogenesis proteins BAI2 and BAI3 are similar to BAI1 in structure, have similar tissue specificities and may also play a role in angiogenesis.

The pathogen had five ABC-type transporters with overlapping substrate specificities that together work to pump toxic chemicals out of the cell.Zwiers, L. H. et al. (2003) ABC transporters of the wheat pathogen Mycosphaerella graminicola function as protectants against biotic and xenobiotic toxic compounds. Molecular Genetics and Genomics 269:499–507 In addition to the mechanisms outlined above, fungi may also develop metabolic pathways that circumvent the target protein, or acquire enzymes that enable metabolism of the fungicide to a harmless substance.

Carbohydrate-binding module family 6 (CBM6) is unusual in that it contains two substrate-binding sites, cleft A and cleft B. Cellvibrio mixtus endoglucanase 5A contains two CBM6 domains, the CBM6 domain at the C-terminus displays distinct ligand binding specificities in each of the substrate-binding clefts. Both cleft A and cleft B can bind cello-oligosaccharides, laminarin preferentially binds in cleft A, xylooligosaccharides only bind in cleft A and beta1,4,-beta1,3-mixed linked glucans only bind in cleft B.

Current data suggest that by quantifying pathway reporter gene expression, molecular phenotyping is able to cluster compounds based on pathway profiles and dissect associations between pathway activities and disease phenotypes simultaneously. Furthermore, molecular phenotyping can be applicable to compounds with a range of binding specificities and is able to triage false positives derived from high-content screening assays. Furthermore, molecular phenotyping allows integration of data derived from in vitro and in vivo models as well as patient data into the drug discovery process.

It was not until 2011 when Lai started to focus on painting and drawing as her main profession. A majority of her painted and drawn works portray anonymous figures intertwined with the surrounding settings which are sometimes identifiable, local spaces (e.g. the interior of a public bus, the walls inside an MTR station). Although these works display local specificities, she emphasized the possibility of going beyond such geographical confines when viewing her pieces, which can essentially be depicting anywhere and even anyone.

Switzerland has a legal framework to combat corruption and several authorities are in charge of curbing the levels of it, particularly when it comes to corruption within Swiss financial institutions. Several sources suggest that the country's fight against corruption has been effective. However, efforts to combat corruption, especially with respect to political party financing have been described as unsatisfactory. Council of Europe's Group of State Against Corruption (GRECO) in its evaluation report noted that specificities of Switzerland's institutions which enjoy considerable public confidence.

Plants cells adhere closely to each other and are connected through plasmodesmata, channels that cross the plant cell walls and connect cytoplasms of adjacent plant cells. Molecules that are either nutrients or signals required for growth are transported, either passively or selectively, between plant cells through plasmodesmata. Protozoans express multiple adhesion molecules with different specificities that bind to carbohydrates located on surfaces of their host cells. cell–cell adhesion is key for pathogenic protozoans to attach en enter their host cells.

Galectin-1 and galectin-3 have been found, surprisingly, to associate with nuclear ribonucleoprotein complexes including the spliceosome. Studies revealed that galectin-1 and -3 are required splicing factors, since removal of the galectins by affinity chromatography with lactose resulted in loss of splicing activity. It appears that the splicing capability of galectins is independent of their sugar-binding specificities. Site-directed mutagenesis studies to the carbohydrate recognition domain removes glycan binding but does not prevent association with the spliceosome.

As only a small part of Crkvine was physically explored so far, the results concerning the tools are still considered preliminary. The stone tools were found in two stratigraphic units, fitting the final phase of the Vinča culture. In general, the tools don't show any major local specificities which would distinguish them from the other late Vinčan tools, or late Neolithic in general. They are almost a textbook examples of what the tool producing looked like in the final Vinčan phase.

The beta chain is approximately 26-28 kDa and it contains 6 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular protein domains, exon 4 encodes the transmembrane domain, and exon 5 encodes the cytoplasmic tail. Within the DQ molecule, both the alpha chain and the beta chain contain the polymorphisms specifying the peptide binding specificities, resulting in up to 4 different molecules. Typing for these polymorphisms is routinely done for bone marrow transplantation.

The DHHC domain was discovered in 1999 and named after a conserved sequence motif found in its protein sequence. Roth and colleagues showed that the yeast Akr1p protein could palmitoylate Yck2p in vitro and inferred that the DHHC domain defined a large family of palmitoyltransferases. In mammals twenty three members of this family have been identified and their substrate specificities investigated. Some members of the family such as ZDHHC3 and ZDHHC7 enhance palmitoylation of proteins such as PSD-95, SNAP-25, GAP43, Gαs.

These specificities are more than practices, they're rituals, like Margaret Lantis described the Canadian tribes and their whaling traditions. Indeed, she asked herself if the dangerous aspect of the hunt was the reason why it was naturally ritualized. There is an inevitable historical and cultural force of this cult in the tribes, as a community but also an individual relation with this cult and nature. In her research she finds some spatial resemblances between the tribes who comes from approximately the same place.

Common tests used to diagnose an aortic dissection include a CT scan of the chest with iodinated contrast material and a transesophageal echocardiogram. The proximity of the aorta to the esophagus allows the use of higher-frequency ultrasound for better anatomical images. Other tests that may be used include an aortogram or magnetic resonance angiogram of the aorta. Each of these tests has pros and cons, and they do not have equal sensitivities and specificities in the diagnosis of aortic dissection.

Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The beta chain is approximately 26-28 kDa and its gene contains 6 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and exon 5 encodes the cytoplasmic tail. Within the DP molecule both the alpha chain and the beta chain contain the polymorphisms specifying the peptide binding specificities, resulting in up to 4 different molecules.

Given some technical specificities, both the nuraghe models and the "oragiana type" baetyls, point to the same conclusion. In this case the necropolis and the statues could be reminiscent of Giants' graves. The layout of the complex recalls in fact the plan of a Giants' grave, and this suggestion is reinforced by the presence of baetyls, a feature typical of the ancient Bronze Age Sardinian tombs. This analogy would attest the ancient architects' will to perpetuate a link with the funerary traditions of their ancestors.

He was a Board Chairperson of the Ukrainian Interdenominational Christian Mission during 2007 - 2011 as well. On the background of the program elaborated with the Greek-Catholic Chaplaincy in the year 2008 he developed the educational seminar for Christian Churches Ministry in Prisons. The goal was to promote active cooperation with Christian Churches and Denominations, taking into account specificities of Ukrainian Penal System institutions. Heads of the regional Prison Management Units of Ukraine made reports about improving of cooperation of prison personnel with chaplains and volunteers.

Reprinted in: Drawing Papers, nº 24, 2001. that has established a feminine gaze and has articulated its differences from the phallic gaze and its relation to feminine as well as maternal specificities and potentialities of "coemergence", offering a critique of Sigmund Freud's and Jacques Lacan's psychoanalysis, is extensively used in analysis of filmsGriselda Pollock, After-effects – After-images. Manchester University Press, 2013Maggie Humm, Feminism and Film. Edinburgh University Press, 1997 by female authors, like Chantal Akerman,Lucia Nagib and Anne Jerslev (ends.), Impure Cinema.

Analogously, beta-ketoacyl- ACP synthase in plants is found in type II FAS; note that synthases in plants have been documented to have a range of substrate specificities. The presence of similar ketoacyl synthases present in all living organisms point to a common ancestor. Further examination of beta-ketoacyl-ACP synthases I and II of E. coli revealed that both are homodimeric, but synthase II is slightly larger. However, even though they are both involved in fatty acid metabolism, they also have highly divergent primary structure.

NAAA cleaves C-N non-peptide bonds in linear amides, particularly ethanolamides. Its mechanism is quite similar to that of AC, which is further supported by AC's ability to cleave N-acylethanolamines (NAEs), albeit at far lower rates and with different specificities. While mechanistic details are not very well known, catalytic activity of NAAA is thought to be activated by Cys-126 and Asp-145. This is the speculated mechanism for the hydrolysis of ethanolamides by NAAA, which is very similar to that of acid ceramise.

Lysine methylation can be reverted by lysine demethylases (PKDMs). Different SET domain-containing proteins possess distinct substrate specificities. For example, SET1, SET7 and MLL methylate lysine 4 of histone H3, whereas Suv39h1, ESET and G9a specifically methylate lysine 9 of histone H3. Methylation at lysine 4 and lysine 9 are mutually exclusive and the epigenetic consequences of site-specific methylation are diametrically opposed: Methylation at lysine 4 correlates with an active state of transcription, whereas methylation at lysine 9 is associated with transcriptional repression and heterochromatin.

Dual specificity protein phosphatase 10 is an enzyme that in humans is encoded by the DUSP10 gene. Dual specificity protein phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the MAPK superfamily (MAPK/ERK, SAPK/JNK, p38), which is associated with cellular proliferation and differentiation. Different members of this family of dual specificity phosphatases show distinct substrate specificities for MAPKs, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli.

These systems therefore solve the specificity problem by possessing such broad substrate specificities that they metabolise almost any non-polar compound. Useful metabolites are excluded since they are polar, and in general contain one or more charged groups. The detoxification of the reactive by-products of normal metabolism cannot be achieved by the systems outlined above, because these species are derived from normal cellular constituents and usually share their polar characteristics. However, since these compounds are few in number, specific enzymes can recognize and remove them.

Chemogenetics is the process by which macromolecules can be engineered to interact with previously unrecognized small molecules. Chemogenetics as a term was originally coined to describe the observed effects of mutations on chalcone isomerase activity on substrate specificities in the flowers of Dianthus caryophyllus. This method is very similar to optogenetics; however, it uses chemically engineered molecules and ligands instead of light and light-sensitive channels known as opsins. In recent research projects, chemogenetics has been widely used to understand the relationship between brain activity and behavior.

Chadian President Idriss Deby said of his arrest that it was a step towards "an Africa free of all evil, an Africa stripped of all dictatorships." Senegal's court, set up with the African Union, charged him with crimes against humanity and torture. That year he was also sentenced to death in absentia for crimes against humanity by a Chadian court. The Tribunal that judged Hissiène Habré in Sénégal is said to have a huge range of specificities On 20 July 2015 the trial started.

However, the empirical findings that constitute S.F.3 prove the exact opposite of Friedman's prediction: very different "genes" survive to the market. As a consequence, a realistic representation of economic behavior should rather allow for firm-specificities, which would explain the heterogeneity found in the data: a point that was clearly made by Richard Nelson and Sidney Winter in their book An Evolutionary Theory of Economic Change.Nelson, R.R. and Winter S.G., An Evolutionary Theory of Economic Change, Harvard University Press, Cambridge, MA, (1982). pp.72-136.

From the outset Cohen’s ethnographic work has been grounded in the specificities of place, as an anchorage of symbolic or moral claims over public amenity and resource as well as a locus of collective identity and belonging. In early work he contrasted rules and rituals of territoriality with protocols of public propriety as two complimentary forms of civic stake holding. In more recent work this model has been refined, drawing on the ideas of Michael Balint and Jay Appleton to outline a psychosocial geography of place attachment.

Zinc finger (Znf) domains are relatively small protein motifs that bind one or more zinc atoms, and which usually contain multiple finger-like protrusions that make tandem contacts with their target molecule. They bind DNA, RNA, protein and/or lipid substrates. Their binding properties depend on the amino acid sequence of the finger domains and of the linker between fingers, as well as on the higher- order structures and the number of fingers. Znf domains are often found in clusters, where fingers can have different binding specificities.

Inspired by Solar Bell, Saraceno developed the idea of entire cities built upon lighter-than-air structures and sustainable energy technologies, lifted by the wind and suspended above the surface of the Earth. This 'flying plaza' represents an inquiry into public space, which according to Saraceno's vision, can be erected in alternative and fossil-free ways. Saraceno imagines spaces of dwellings as new urban skyscapes: flying buildings elevated by wind power alone, which erase the boundaries defined by geopolitics, and start to respond to local specificities.

It is poorly understood how ANCA are developed, although several hypotheses have been suggested. There is probably a genetic contribution, particularly in genes controlling the level of immune response – although genetic susceptibility is likely to be linked to an environmental factor, some possible factors including vaccination or exposure to silicates. Two possible mechanisms of ANCA development are postulated, although neither of these theories answers the question of how the different ANCA specificities are developed, and there is much research still being undertaken on the development of ANCA.

The assembly of filamentous actin arises as a result of weak, noncovalent interactions between G-actin and appears in the arrangement of a two-stranded asymmetrical helical polymer. The asymmetrical nature of F-actin allows for distinct binding specificities at each terminus. The terminus that presents an actin subunit with an exposed ATP binding site is commonly labeled the "(-) end". Whereas, the opposite end of the polymer that presents a cleft and lacks a free ATP binding site is referred to as the "(+) end".

This is because more Van der Waals interactions can occur between sugar and binding pocket. Carbohydrate binding is calcium independent, unlike C-type lectins. The strength of ligand binding is determined by a number of factors: The multivalency of both of ligand and the galectin, the length of the carbohydrate and the mode of presentation of ligand to carbohydrate recognition domain. Different galectins have distinct binding specificities for binding oligosaccharides depending on the tissue in which they are expressed and the function that they possess.

Different connexins may exhibit differing specificities for solutes. For example, adenosine passed about 12-fold better through channels formed by Cx32 while AMP and ADP passed about 8-fold better, and ATP greater than 300-fold better, through channels formed by Cx43. Thus, addition of phosphate to adenosine appears to shift its relative permeability from channels formed by Cx32 to channels formed by Cx43. This may have functional consequence because the energy status of a cell could be controlled via connexin expression and channel formation.

The Aran Islands is a four part collection of journal entries regarding the geography and people of the Aran Islands. It was completed by John Millington Synge in 1901 and first published in 1907. It is based on Synge's multiple travels through the Irish speaking and predominately rural set of islands off the Western coast of Ireland. The book presents many of the local specificities of the Aran Island people while simultaneously contextualizing the Aran Islands as part of broader European and global commercial networks.

Archives of Osteoporosis is a peer-reviewed medical journal published by Springer Science+Business Media.Journal homepage It was established in 2006 and is an official journal of the International Osteoporosis Foundation and the United States' National Osteoporosis Foundation. The journal is published yearly and covers the specificities of regions around the world concerning epidemiology, including reference values for bone density and bone metabolism, as well as clinical aspects of osteoporosis and other bone diseases. The co- editors-in-chief are R. Lindsay and J.A. Kanis.

These domains are joined by residue loops to form a substrate binding cleft, where the glucosyl group acceptor binds. Although H. orenii is a non-photosynthetic bacterium, various studies indicate that the structure of its SPS is similar to plant SPS. First, antibodies with high specificities for plant SPS also target the bacterial SPS, indicating the structure is conserved enough for the antibody to recognize the enzyme as an antigen. Furthermore, genomic studies reveal that closely related plant homologues exhibit up to 54% sequence identities.

Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene maps in a region that contains the BRCA1 locus which confers susceptibility to breast and ovarian cancer. Although DUSP3 is expressed in both breast and ovarian tissues, mutation screening in breast cancer pedigrees and in sporadic tumors was negative, leading to the conclusion that this gene is not BRCA1.

Substrate specificities that are common among all coronavirus 3CL proteases The 3C-like protease is able to catalytically cleave a peptide bond between a glutamine at position P1 and a small amino acid (serine, alanine, or glycine) at position P1'. The SARS coronavirus 3CLpro can for instance self-cleave the following peptides: The protease is important in the processing of the coronavirus replicase polyprotein (). It is the main protease in coronaviruses and corresponds to nonstructural protein 5 (nsp5). It cleaves the coronavirus polyprotein at 11 conserved sites.

The geopark is located at an extension foot mount East of the Himalayas. Geoheritages date from the Cambrian (about 550 million years ago) to the present in seven different stages and include palaeobiology, stratigraphy, geomophology, tectonics, karst, caves and also important faults. The geology in this geopark reflects important events in Earth history, like of two mass extinction boundaries of Frasnian-Famennian (360 million years ago) and Permian-Triassic (250 million years ago). This includes 3 groups of sedimentary, igneous and metamorphic rocks, as well as stratigraphic, lithostratigraphic and biostratigraphic specificities.

The various paralogues in a mammal have differing but overlapping substrate specificities and tissue distributions as summarized by Hagenbuch and Meier. These authors also provide a phylogenetic tree of the mammalian members of the family, showing that they fall into five recognizable subfamilies, four of which exhibit deep branching sub-subfamilies. However, all sequences within a subfamily are >60% identical while those between subfamilies are >40% identical. As also shown by Hagenbuch and Meier, all but one (OatP4a1) of the mammalian homologues cluster together, separately from all other animal (insect and worm) homologues.

The plants are fragile and require regular care of experienced farmers. Diseases and insects can heavily reduce the production, and the cost of chemical products used impact the farmer harder when the vanilla prices are low. As the vanilla production falls, the price increase and the government started a new program of development, starting a new cycle. Despite the high price of Tahitian dried vanilla on the international market, it usually still finds buyers in the high-end market because of the specificities of its cultivar and quality.

These risks become critical in case of vulnerable, non- compliant or rogue nations and organisations. "The FATF standards are implemented without any form of tailoring to the specificities of Islamic finance. The FATF, the Islamic finance standard-setters, and the national regulators should seek a greater understanding of the specific ML/TF risks that may arise in Islamic finance and develop an appropriate response."Nadim Kyriakos-Saad, Manuel Vasquez, et el, 2016, Islamic Finance and Anti-Money Laundering andCombating the Financing of Terrorism (AML/CFT), International Monetary Fund.

Mediated stylistics or media stylistics is a new and still emerging approach to the analysis of media texts (e.g. news programs, newspaper articles). It aims to take seriously two ideas: first, that media texts involve 'the construction of stories by other means'; and second, that in an age marked by digital connectivity, media texts are inherently interactive phenomena. To meet this twofold aim, mediated stylistics has brought together the analytic toolkits of discursive psychology—which is finely attuned to the contextual specificities of interactionPotter, J. (1996) Representing Reality.

Memory and naïve B cells normally exist in relatively small numbers. As the body needs to be able to respond to a large number of potential pathogens, it maintains a pool of B cells with a wide range of specificities. Consequently, while there is almost always at least one B (naive or memory) cell capable of responding to any given epitope (of all that the immune system can react against), there are very few exact duplicates. However, when a single B cell encounters an antigen to which it can bind, it can proliferate very rapidly.

Peptidyl arginine deiminase, type III, also known as PADI3, is a protein which in humans is encoded by the PADI3 gene. This gene encodes a member of the peptidyl arginine deiminase family of enzymes, which catalyze the post- translational deimination of proteins by converting arginine residues into citrullines in the presence of calcium ions. The family members have distinct substrate specificities and tissue-specific expression patterns. The type III enzyme modulates hair structural proteins, such as filaggrin in the hair follicle and trichohyalin in the inner root sheath, during hair follicle formation.

The results obtained from metabarcoding are limited or biased to the frequency of occurrence. It is also problematic that far from all species have barcodes attached to them. Even though metabarcoding may overcome some practical limitations of conventional sampling methods, there is still no consensus regarding experimental design and the bioinformatic criteria for application of eDNA metabarcoding. The lack of criteria is due to the heterogeneity of experiments and studies conducted so far, which dealt with different fish diversities and abundances, types of aquatic ecosystems, numbers of markers and marker specificities.

The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which are associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli.

Depending on the amino acids located at the calcium binding site and the loops, C2 domains can have different specificities for calcium and lipid binding, suggesting that they are evolved to function in different environments. The DysF domain exists as an internal duplication where an inner DysF domain is surrounded by an outer DysF domain. Such structure is a result of gene duplication and both inner and outer DysF domains have adopted the same fold. The structure of DysF is mainly consist of two antiparallel long β-strands.

Phosphodiesterases (PDEs) are a superfamily of enzymes. This superfamily is further classified into 11 families, PDE1 - PDE11, on the basis of regulatory properties, amino acid sequences, substrate specificities, pharmacological properties and tissue distribution. Their function is to degrade intracellular second messengers such as cyclic adenine monophosphate (cAMP) and cyclic guanosine monophosphate (cGMP) which leads to several biological processes like effect on intracellular calcium level by the Ca2+ pathway. Phosphodiesterase 5 (PDE5) is widely expressed in several tissues in the body for example brain, lung, kidney, urinary bladder, smooth muscle and platelets.

They characterized all Fur proteins in Aspergillus nidulans. Homology modelling, substrate docking, molecular dynamics and systematic mutational analysis in three Fur transporters with distinct specificities identified residues critical for function and specificity, located within a major substrate binding site, in transmembrane segments TMS1, TMS3, TMS6 and TMS8. They predicted and confirmed that residues determining substrate specificity are located not only in the major substrate binding site, but also in a putative outward-facing selectivity gate. Their evolutionary and structure-function analyses led to the concept that selective channel-like gates may contribute to substrate specificity.

The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which are associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli.

Phages that are related to lambda have different N genes and different antitermination specificities. The region on the phage genome in which the nut sites lie has a different sequence in each of these phages, and each phage must therefore have characteristic nut sites recognized specifically by its own pN. Each of these pN products must have the same general ability to interact with the transcription apparatus in an antitermination capacity, but each product also has a different specificity for the sequence of DNA that activates the mechanism.

Despite its aforementioned advantages as a specialized tool, the B1H system does have some drawbacks. First, the B1H selection system is limited in its capacity to determine the binding specificities of transcription factors with lengthy binding sites. This arises from the fact that the number of randomized “prey” clones required to represent all possible target sequences increases exponentially with the number of nucleotides in that target sequence. Second, some eukaryotic factors may not express or fold efficiently in the bacterial system, attributed to differing regulatory networks and transcriptional machinery.

An Escherichia coli genetic system for studying the relationship between I-CreI structure and its homing site specificity was created in 1997. In 1997, the structure of the I-CreI protein was determined, and in 1998, its crystal structure bound to its native DNA homing site was solved, greatly aiding research in altering the homing site recognition of the protein. Mutant forms of the protein have since been created that exhibit altered homing site specificity. A genetic system in Saccharomyces cerevisiae has also been created, yielding additional I-CreI mutants with modified homing site specificities.

The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen- activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which is associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli.

Hayes, L. J., Pickett, M. A., Conlan, J. W., Ferris, S., Everson, J. S., Ward, M. E., & Clarke, I. N. (1990). The major outer membrane proteins of Chlamydia trachomatis serovars A and B: Intra-serovar amino acid changes do not alter specificities of serovar- and C subspecies-reactive antibody-binding domains. Journal of General Microbiology, 136(8), 1559–1566. DOI:10.1099/00221287-136-8-1559 Furthermore, there have been over 220 Chlamydia vaccine trials done on mice and other non-human host species to target C. muridarum and C. trachomatis strains.

Anthocyanins (delphinidin pictured) confer plants, particularly their flowers, with a variety of colours to attract pollinators and a typical example of plant secondary metabolite. Plants produce a large number of secondary metabolites thanks to enzymes that, unlike those involved in primary metabolism, are less catalytically efficient but have a larger mechanistic elasticity (reaction types) and broader specificities. The liberal drift threshold (caused by the low selective pressure due to the small population size) allows the fitness gain endowed by one of the products to maintain the other activities even though they may be physiologically useless.

Council of Europe's Group of State Against Corruption (GRECO) in its evaluation report noted that specificities of Switzerland's institutions which enjoy considerable public confidence. It underlines, however, that the very organisation of the system allows subtle pressure to be exerted on politicians and the judiciary. Transparency International's 2017 Corruption Perception Index ranks Switzerland as the 5th least corrupt state out of 180 countries. In 2018 the Tax Justice Network ranked Switzerland's banking sector as the "most corrupt" in the world due to a large offshore banking industry and very strict secrecy laws.

Another recent extension is the triplet Markov model, in which an auxiliary underlying process is added to model some data specificities. Many variants of this model have been proposed. One should also mention the interesting link that has been established between the theory of evidence and the triplet Markov models and which allows to fuse data in Markovian contextBoudaren et al., M. Y. Boudaren, E. Monfrini, W. Pieczynski, and A. Aissani, Dempster-Shafer fusion of multisensor signals in nonstationary Markovian context, EURASIP Journal on Advances in Signal Processing, No. 134, 2012.

Examples of degeneracy are found in the genetic code, when many different nucleotide sequences encode the same polypeptide; in protein folding, when different polypeptides fold to be structurally and functionally equivalent; in protein functions, when overlapping binding functions and similar catalytic specificities are observed; in metabolism, when multiple, parallel biosynthetic and catabolic pathways may coexist. More generally, degeneracy is observed in proteins of every functional class (e.g. enzymatic, structural, or regulatory), protein complex assemblies, ontogenesis, the nervous system, cell signalling (crosstalk) and numerous other biological contexts reviewed in.

As nuclear RNA emerges from RNA polymerase, RNA transcripts are immediately covered with RNA-binding proteins that regulate every aspect of RNA metabolism and function including RNA biogenesis, maturation, transport, cellular localization and stability. All RBPs bind RNA, however they do so with different RNA-sequence specificities and affinities, which allows the RBPs to be as diverse as their targets and functions. These targets include mRNA, which codes for proteins, as well as a number of functional non-coding RNAs. NcRNAs almost always function as ribonucleoprotein complexes and not as naked RNAs.

The array is probed with a complex protein solution such as a cell lysate. Analysis of the resulting binding reactions using various detection systems can provide information about expression levels of particular proteins in the sample as well as measurements of binding affinities and specificities. This type of microarray is especially useful in comparing protein expression in different solutions. For instance the response of the cells to a particular factor can be identified by comparing the lysates of cells treated with specific substances or grown under certain conditions with the lysates of control cells.

The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which are associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli.

Two α-fucosyltransferase genes, FUT4 and FUT6, both belonging to GT37 family, encode enzymes which add α-1,2-fucose residues to AGPs. They appear to be partially redundant as they display somewhat different AGP substrate specificities. A GT77 family member, REDUCED ARABINOSE YARIV (RAY1), was found to be a β-arabinosyltransferase that adds a β-Araf to methyl β-Gal of a Yariv-precipitable wall polymer. More research is expected to functionally identify other genes involved in AGP glycosylation and their interactions with other plant cell wall components.

The creation of synthetic small molecules with affinities and sequence specificities for predetermined DNA sequences makes it possible to design cell-permeable molecules for the regulation of gene expression. The use of small molecules to regulate gene expression in living cells has possible application to human medicine. The most important of these small molecules are pyrrole–imidazole polyamides. Dervan's lab has identified pairing rules to control the DNA sequence specificity of minor-groove binding polyamides that contain the aromatic ring amino acids hydroxypyrrole (Hp), imidazole (Im), and pyrrole (Py).

Brain-specific angiogenesis inhibitor 3 is a protein that in humans is encoded by the BAI3 gene. BAI1, a p53-target gene, encodes brain-specific angiogenesis inhibitor, a seven-span transmembrane protein and is thought to be a member of the secretin receptor family. Brain-specific angiogenesis proteins BAI2 and BAI3 are similar to BAI1 in structure, have similar tissue specificities and may also play a role in angiogenesis. }} The adhesion GPCR BaI3 is an orphan receptor that has a long N-terminus consisting of one cub domain, five BaI Thrombospondin type 1 repeats, and one hormone binding domain.

Previously it was called the Place du Trône, where guillotines were set up during the French Revolution. From the 1960s to 2010, the decorative style Mouton-Duvernet was applied to the platforms of lines 2, 6 and 9 with some specificities. The tiles of line 6 have particular patterns, while those of lines 2 and 9 are bevelled and in two shades of orange, colour randomly distributed on the walls and the tympans. The lighting strips are fitted with metal blades on line 2, while they are typical of the Mouton style on lines 6 and 9.

The haik is of Arab-Andalusian origin, and present throughout the Maghreb. In 1792, the m'laya, a black veil, popular in the eastern part of Algeria, made its appearance to mourn Salah Bey, Bey of Constantine. Made from wool, silk or synthetic silk fabric, the haik succeeded, in a very short time, to spread throughout all regions of the country, but its use was adapted to the socio- cultural specificities of the region. One variety of the haik, the haik mrama, became very popular among women for its design, the way it was worn, and the quality of the fabric used by artisans.

Further biochemical studies elucidated specificity and localization of human Sulfs 1 and 2. Sulf1 and 2 hydrophilic domains associate with the cell membrane components through electrostatic interactions and not by integration with into the lipid bilayer. In addition to cell membrane association, Sulfs also secreted freely into the media, which contrasts the findings with QSulf1 and 2. Biochemical analysis of HSPGs in Sulf 1 and 2 knockout MEFS reveal enzyme specificities to disulfated and, primarily, trisulfated 6S disaccharide units UA-GlcNS(6S) and UA(2S)-GlcNS(6S) within the HS chain, with specific exclusion of monosulfated disaccharide units.

Peptidyl arginine deiminase, type I, also known as PADI1, is a protein which in humans is encoded by the PADI1 gene. This gene encodes a member of the peptidyl arginine deiminase family of enzymes, which catalyze the post- translational deimination of proteins by converting arginine residues into citrullines in the presence of calcium ions. The family members have distinct substrate specificities and tissue-specific expression patterns. The type I enzyme is involved in the late stages of epidermal differentiation, where it deiminates filaggrin and keratin K1, which maintains hydration of the stratum corneum, and hence the cutaneous barrier function.

Because both zinc fingers and TALEs happen in repeated patterns, different combinations can be tried to create a wide variety of sequence specificities. Zinc fingers have been more established in these terms and approaches such as modular assembly (where Zinc fingers correlated with a triplet sequence are attached in a row to cover the required sequence), OPEN (low-stringency selection of peptide domains vs. triplet nucleotides followed by high-stringency selections of peptide combination vs. the final target in bacterial systems), and bacterial one-hybrid screening of zinc finger libraries among other methods have been used to make site specific nucleases.

In 2010 Jou, et al., found that patients diagnosed with oral squamous cell carcinoma had elevated levels transferrin in saliva compared to healthy controls and, moreover, that salivary transferrin measurement using ELISA technique was “highly specific, sensitive, and accurate for the early detection of oral cancer.” A 2009 study reported that the levels of two biomarkers, Cyclin D1 (increased compared to controls) and Maspin (decreased compared to controls), had sensitivities and specificities of 100% for oral cancer detection when measured in saliva. Saliva testing for specific mRNAs has been found to possess significant potential for oral cancer diagnosis.

Apart from obvious analytical abilities, authors are asked to write quality text and a sensitivity to illustration. A "Découvertes" is not a book of authorship, the author is only one of the many speakers. Bruno Blasselle, director of the Bibliothèque de l'Arsenal, author of two volumes of ('History of the Book', and ), and co-author of the 88 title , explains his experience of working for the collection: "For an author, to write a Découvertes title is to be trapped, to put oneself in a situation of being obliged to go beyond his/her own formulation." The cover design is one of the specificities.

All join together what is apart or mend what has been rent, broken, or sundered." In Marshall's opinion, this loss of individual identity not only blurs specificities, it creates new identities found in community, which Marshall points out may lead to some understanding of Shakespeare's opinions on love and marriage. Further, the mechanicals understand this theme as they take on their individual parts for a corporate performance of Pyramus and Thisbe. Marshall remarks that "To be an actor is to double and divide oneself, to discover oneself in two parts: both oneself and not oneself, both the part and not the part.

In addition to a gRNA target, Cas9 requires binding to a specific 2-6 nucleotide sequence PAM. In commonly used SpCas9 systems the PAM motif is 5’ NGG 3’, where N represents any of the four DNA nucleotides. The requirement of the PAM sequence can cause specificity limitations as some regions will not have an available target sequence to make a desired genetic modification. The PAM sequence can be edited to non-canonical NAG and NGA motifs which not only improve the specificity but also reduced off-target effects. A D1135E mutant appears to alter PAM specificities.

Protein phosphatase 2 (formerly named type 2A) is one of the four major Ser/Thr phosphatases and is implicated in the negative control of cell growth and division. Protein phosphatase 2 holoenzymes are heterotrimeric proteins composed of a structural subunit A, a catalytic subunit C, and a regulatory subunit B. The regulatory subunit is encoded by a diverse set of genes that have been grouped into the B/PR55, B'/PR61, and B/PR72 families. These different regulatory subunits confer distinct enzymatic specificities and intracellular localizations to the holozenzyme. The product of this gene belongs to the B family.

Even today, an Alsatian and a Mosellan have their local form to designate their agglomeration. This also applies to village names in Lorraine dialect and beyond for all regions of France in local languages and dialects. The difference is that Moselle suffered the arrival of 'prussification' as a denial of its specificity in view of the brutality of certain measures that followed the de facto annexation after the abandonment of the territories by the parliament meeting in Bordeaux in May 1871. This annexation was difficult to experience throughout the annexed Moselle because of the desire to 'prussify' Moselle by erasing its specificities.

These maps had a first layout of the five European routes, Atlantic, Mediterranean, Nordic, Central and Western route. Approved by the rural tourism group of the Assembly of European Regions, the route map took the following denomination: Touring Nature, the Pan European Routes to rural tourism (based on the village + sustainable development European label). The Minister of Planning and Hungarian Tourism gave a press conference before a dozen journalists from the print and two television channels. He considered this private initiative as an example to follow for all the regional territories in Europe wishing to promote their specificities.

Affibody molecules are based on a three-helix bundle domain, which can be expressed in soluble and proteolytically stable forms in various host cells on its own or via fusion with other protein partners. They tolerate modification and are independently folding when incorporated into fusion proteins. Head-to-tail fusions of Affibody molecules of the same specificity have proven to give avidity effects in target binding, and head-to-tail fusion of Affibody molecules of different specificities makes it possible to get bi- or multi-specific affinity proteins. Fusions with other proteins can also be created genetically or by spontaneous isopeptide bond formation.

The European Parliament periodically commissions opinion polls and studies on public opinion trends in Member States to survey perceptions and expectations of citizens about its work and the overall activities of the European Union. Topics include citizens' perception of the European Parliament's role, their knowledge of the institution, their sense of belonging in the European Union, opinions on European elections and European integration, identity, citizenship, political values, but also on current issues such as climate change, current economy and politics, etc.. Eurobarometer analyses seek to provide an overall picture of national situations, regional specificities, socio-demographic cleavages, and historical trends.

Standard concentration ratios have performed poorly in explaining margins in certain markets, especially electricity markets, where supply and demand must be balanced in real time. As to account for the specificities of electricity markets the specific structural measures such as the Pivotal Supplier Index and Residual Supplier Index have been proposed. The Herfindahl index and the concentration ratios focus on the market shares of companies, but measures such as the PSI and the RSI identify the "pivotalness" of companies to meeting the demand on the system. A company that is very pivotal can be said to have a potential for high market power.

In traditional animist Waodani worldview, there is no distinction between the physical and spiritual worlds, and spirits are present throughout the world. The Waodani once believed that the entire world was a forest (and used the same word, ', for both). The Oriente's rain forest remains the essential basis of their physical and cultural survival. For them, the forest is home, while the outside world is considered unsafe. In short, as one Waodani put it, “The rivers and trees are our life.” In all its specificities, the forest is woven into each Waodani life and conceptions of the world.

The different specificities of the Tcrs born by the individual T cells are generated by a special mechanism during the lymphocyte development from precursor cells in the thymus. The generation is entirely random, so that receptors arise against all possible antigens, including those borne by the individual in which the differentiation takes place (the self-molecules). The cells with receptors for self-molecules must be eliminated to prevent an immune reaction against the individual's own components. The eliminated Tcrs might, however, by chance have had the capability of recognizing certain foreign antigens (nonself) in association with the nonresponder’ own Mhc molecules.

These writers generally tackled domestic issues, such as relations between the sexes, family, friendship and war, Eileen Chang's writing uses the spatial specificities of the modern apartment as essential to the construction of a vision of life in wartime.Nicole Huang, "Introduction," in Eileen Chang, Written on Water, translated by Andrew F. Jones (New York: Columbia University Press, 2005), xxi. But they were revolutionary in giving direct expression to female subjectivity. Ding Ling's story Miss Sophia's Diary exposes the thoughts and feelings of its female diarist in all their complexity. The 1920s and 1930s saw the emergence of spoken drama.

In polymer chemistry "cross-linking" usually refers to the use of cross-links to promote a change in the polymers' physical properties. When "crosslinking" is used in the biological field, it refers to the use of a probe to link proteins together to check for protein–protein interactions, as well as other creative cross-linking methodologies. Although the term is used to refer to the "linking of polymer chains" for both sciences, the extent of crosslinking and specificities of the crosslinking agents vary greatly. As with all science, there are overlaps, and the following delineations are a starting point to understanding the subtleties.

There have been many debates surrounding the regulatory exemptions for hydraulic fracturing. It has been noted that if not for the exemption for hydraulic fracturing in the Energy Policy Act of 2005 or the RCRA exemption that exempts oil and gas waste from being designated as a hazardous waste, underground injection would have included fracking operations, and the EPA would have had the power to further regulate it as well as enforcing disclosure requirements. The oil and gas industry supports the idea that states should control the regulatory specificities of fracking. Some contend that these exemptions are carefully analyzed.

Heterothallism is the most common mating system in Basidiomycota and in Agaricomycotina (the mushroom-forming Fungi) about 90% of the species are heterothallic. The tetrapolar type of mating system is ruled by two unlinked mating loci termed A and B (in Agaricomycotina) or b and a (in Ustilaginomycotina and Pucciniomycotina), both of which can be multiallelic. The combination of A and B (or b and a) alleles, termed mating type, determine the specificity or sexual identity of the individual harboring them. Only individuals with different specificities are compatible with each other and therefore able to start the mating event.

Along with Turkey's aspirations to join the European Union population groups with specificities started receiving more attention on the basis of their ethnicity or culture. In Middle Eastern countries, which were created from the dismembered Ottoman Empire (and were initially under British protectorate) the fate of the ethnos was better. The Al Jeish al Arabi (Arab Legion), created in Trans-Jordan under the influence of Lawrence, in significant part consisted of Chechens — arguably because the Bedouin were reluctant to serve under the centralized command. In addition, the modern city of Amman was born after Circassians settled there in 1887.

The amino acid residues in the structural calcium site are conserved among intelectins, thus it is likely that most, if not all, intelectins have two structural calcium ions. In the ligand binding site of XEEL and hIntL-1, the exocyclic vicinal diol of the carbohydrate ligand directly coordinates to the calcium ion. There are large variations in the ligand binding site residues among intelectin homologs suggesting that the intelectin family may have broad ligand specificities and biological functions. As there is no intelectin numbering conventions in different organisms, one should not assume functional homology based on the intelectin number.

The trendy district of Bairro Alto, in Lisbon, is an example of this. Portuguese traditional architecture is quite similar to others of the Mediterranean, and whether a traditional country house or a suburban apartment bloc, Portuguese buildings and towns will look like those in Italy or Spain. This apart from the specificities of Portuguese architecture and its traditions, also excluding high rise projects inspired by the English Post-War tradition, the Socialist Bloc tradition and nowadays modern trends. Another strange, but somewhat common sight in Portugal, are the Swiss-like chalets, built by Portuguese people who lived in Switzerland or Germany.

Water treatment plant Barra da Tijuca, Rio de Janeiro In January 2007, at the beginning of his second term, the President signed a new federal water and sanitation law (Lei 11.445/07 para o saneamento básico) that outlines federal policies in the sector. The law aims at increasing investments to provide universal access to water and sanitation, while taking into account local specificities and using appropriate technologies that are in line with users' ability to pay. It also aims at increasing transparency and "social control". The law is a compromise between diverging interests of a broad array of stakeholders.

With an emphasis on simplicity and generalizability, Billard was able to ensure that neither specificities about the environment nor the particular robotic agent were necessary for success of the architecture in practice. During her graduate work, Billard continued to use the teacher- learner situation as an environment with which to develop robots with social communication abilities. Billard tested her novel learning architecture and found that learning through imitation can be achieved with simple computations and a photodetection system between the teacher and the learner to impart information about movement. However, Billard mentioned in her thesis there are still limitations to learning capabilities when the only means of learning is by imitation.

The stature of Sinantropus was calculated by Weidenreich to be 156 cm for males and 144 cm for females. This contrasts the claims of Soviet anthropologists, who suggested a higher stature, namely 162 cm for males and 152 cm for females. More specificities described by researchers indicated that Sinanthropus had a different jaw than found in gorillas, similar cranial size to Pithecanthropus, and smaller molars than those found in Pithecanthropus. Researchers were also able to conclude that the teeth found were larger in comparison to Neanderthal men found at the time and the upper canine was long, wide, and similar to that of a tusk.

The promotion of the Channel Arc Manche co-operation network originates from two main concerns : # To develop the recognition of the Channel Arc among political and institutional stakeholders, may they be private, local, national or European. It entails interventions at the national and European levels, the reinforcement of a common strategic vision to be able to have influence on the European regional policy, and for the specificities of this maritime space to be taken into account. # Promote and intensify Franco-British Cooperation By constituting a stakeholders' network on coastal and maritime issues, by encouraging co-operation in areas of common interest, by supporting exchanges in economic, social, cultural and administrative realms.

From 1972, Moshé Yaniv decided to focus his research on the biology of oncogenic DNA viruses such as Polyome, SV40 and later on papilloma viruses in collaboration with Professor Gérard Orth. It highlights the chromatin structure of the viral genome and the absence of nucleosomes (histone octamers) on the sequences of expression regulation of viral and cellular genes.Saragosti S, et al., « Absence of nucleosomes in a fraction of SV40 chromatin between the origin of replication and the region coding for the late leader RNA. », Cell, 1980, p. 20:65Herbomel P, et al., « Two distinct enhancers with different cell specificities coexist in the regulatory region of polyoma. », Cell, 1984, p.

The DNA-binding domains of individual ZFNs typically contain between three and six individual zinc finger repeats and can each recognize between 9 and 18 basepairs. If the zinc finger domains perfectly recognize a 3 basepair DNA sequence, they can generate a 3-finger array that can recognize a 9 basepair target site. Other procedures can utilize either 1-finger or 2-finger modules to generate zinc- finger arrays with six or more individual zinc fingers. The main drawback with this procedure is the specificities of individual zinc fingers can overlap and can depend on the context of the surrounding zinc fingers and DNA.

Transnationality is the principal of acting at a geographical scale larger than that of states, so as to take into account the interests of a supranational entity. Transnational policies or programmes are not simply aggregations of national policies or programmes, but seek to submerge these within a greater whole. According to Aihwa Ong, the term differs from that of transnationalism, as transnationalism refers "to the cultural specificities of global processes, tracing the multiplicity of the uses and conceptions of "culture"" whereas transnationality is "the condition of cultural interconnectedness and mobility across space". Transnationality is practised by organisations such as the United Nations and the European Union.

Ultrastructure of Bodo saltans virus particles and its replication Klosneuvirus (KNV, also KloV) is a new type of giant virus found by the analysis of low-complexity metagenomes from a wastewater treatment plant in Klosterneuburg, Austria. It has a 1.57-Mb genome coding unusually high number of genes typically found in cellular organisms, including aminoacyl transfer RNA synthetases with specificities for 19 different amino acids, over 10 translation factors and several tRNA-modifying enzymes. Klosneuvirus, Indivirus, Catovirus and Hokovirus, are part of a group of giant viruses denoted as Klosneuviruses or Klosneuvirinae, a proposed subfamily of the Mimiviridae. Species in this clade include Bodo saltans virus infecting the kinetoplastid Bodo saltans.

There have been small movements to preserve and develop Garhwali language and culture but primarily, these have been restricted to individuals and communities. The Akhil Garhwal Sabha, a citizen's group in Dehradun aims to raise awareness amongst young Garhwalis about Garhwali language and culture. From 2012 onwards, it has been organising an annual 2 week Garhwali language workshop in which it provides training in the language and presents the interesting specificities of the language to the learners in Dehradun. It has also been the organiser of a series of 7 days cultural programmes called Kautig Uttarakhand Mahotsava from 1998 onwards to promote traditional folk dances and traditions of Uttarakhand.

Across all living organisms, regulation of gene expression is controlled by interactions between DNA- binding regulatory proteins (transcription factors) and cis-regulatory elements, DNA sequences in or around genes that act as target sites for DNA- binding proteins. By binding to cis-regulatory sequences and to each other, transcription factors fine-tune transcriptional levels by stabilizing/destabilizing binding of RNA polymerase to a gene's promoter. But despite their importance and ubiquity, little is known about where exactly each of these regulatory proteins binds. Literature suggests that nearly 8% of human genes encode transcription factors and the functions and specificities of their interactions remain largely unexplored.

This evaluation is performed by Professors and or Researchers aiming to assess the student's professional knowledge and skills. For instance, as defined by the Brazilian National Council of Education (Ministry of Education), a Licenciatura modality in Biological Sciences should include, in addition to specific topics of Biology, contents in the areas of Chemistry, Physics and Health, to attend elementary and secondary education. Pedagogical training, in addition to its specificities, should contemplate an overview of the education and the formative processes of the students. It should also emphasize the instrumentation for the teaching of Sciences at the fundamental level and for the teaching of biology at the intermediate level.

Diagnosis of an IgE-mediated soy allergy is based on the person's history of allergic reactions, skin prick test (SPT), patch test and measurement of soy protein specific serum immunoglobulin E (IgE or sIgE). A negative IgE test does not rule out non-IgE mediated allergy, which is also described as cell-mediated allergy. SPT and sIgE have sensitivities of 55% and 83%, respectively, and specificities of 68% and 38%. These numbers mean that either test may miss diagnosing an existing soy allergy, that both could be positive for other food allergens, and that the tests have wide variability leading to a false-positive outcome of 30%.

Title page from a Latin edition of Colliget, Averroes' main work in medicine Averroes, who served as the royal physician at the Almohad court, wrote a number of medical treatises. The most famous was al-Kulliyat fi al- Tibb ("The General Principles of Medicine", Latinized in the west as the Colliget), written around 1162, before his appointment at court. The title of this book is the opposite of al-Juz'iyyat fi al-Tibb ("The Specificities of Medicine"), written by his friend Ibn Zuhr, and the two collaborated intending that their works complement each other. The Latin translation of the Colliget became a medical textbook in Europe for centuries.

Most domains have a very broad substrate specificity and usually only the A-domain determines which amino acid is incorporated in a module. Ten amino acids that control substrate specificity and can be considered the 'codons' of nonribosomal peptide synthesis have been identified, and rational protein design has yielded methodologies to computationally switch the specificities of A-domains. The condensation C-domain is also believed to have substrate specificity, especially if located behind an epimerase E-domain-containing module where it functions as a 'filter' for the epimerized isomer. Computational methods, such as SANDPUMA and NRPSpredictor2, have been developed to predict substrate specificity from DNA or protein sequence data.

The legume lectins (or L-type lectins) are a family of sugar-binding proteins or lectins found in the seeds and, in smaller amounts, in the roots, stems, leaves and bark of plants of the family Fabaceae. The exact function of the legume lectins in vivo is unknown but they are probably involved in the defense of plants against predators. Related proteins in other plant families and in animals have also been found. They have been used for decades as a model system for the study of protein-carbohydrate interactions, because they show an amazing variety of binding specificities and are easy to obtain and purify.

Once assessment is completed and palliative sedation has been decided for the person, a written consent for administration to proceed must be given by the individual. The consent must state their agreement for sedation and lowering their consciousness, regardless each individual's stage in illness or the treatment period of palliative sedation. In order to make a decision, one must be sufficiently informed of their disease state, the specificities and implications of treatment, and potential risks they may face during the treatment. At the time of consent, the person should fully be aware of and understand all necessary legal and medical consequences of palliative sedation.

Li Xinggang is always interested in the Chinese feature in architecture, so he focuses on the classical Chinese gardens and their contemporary characteristics, as well as applies the modern architecture languages of structure and form, skin and material. He intends to strengthen personal design power, and express his own value judgment and architectural philosophy on these two main routes. He has won several architecture honors and awards, and has also been invited to take part in some exhibitions concerning architecture and art. Atelier Li Xinggang advocates the process of "Research + Design", and emphasizes the response of architecture to the specificities of context, nature, site, material, and user.

The work was criticised by some for failing to probe Marshal Philippe Pétain's attitude towards the Resistance.Bénédicte Vergez-Chaignon, Les Vichysto-résistants: de 1940 à nos jours, Perrin, 2008, p. 721. In 2002, Venner wrote Histoire et tradition des Européens (History and Tradition of the Europeans), in which he set out what he believed to be the common cultural bases of European civilisation, and outlined his theory of "traditionalism" (a concept that, inter alia, assesses the specificities of each society and civilisation). Venner served as editor in chief of the revue Enquête sur l'histoire (Study of History, or Historical Inquest) until its dissolution in the late 1990s.

If a person has group O blood, the H antigen remains unmodified. Therefore, the H antigen is present more in blood type O and less in blood type AB. Hh antigen system - diagram showing the molecular structure of the ABO(H) antigen system Two regions of the genome encode two enzymes with very similar substrate specificities: the H locus (FUT1) which encodes the Fucosyl transferase and the Se locus (FUT2) that instead indirectly encodes a soluble form of the H antigen, which is found in bodily secretions. Both genes are on chromosome 19 at q.13.3. - FUT1 and FUT2 are tightly linked, being only 35 kb apart.

Multiple copies of the V, D and J gene segments exist, and are tandemly arranged in the genomes of mammals. In the bone marrow, each developing B cell will assemble an immunoglobulin variable region by randomly selecting and combining one V, one D and one J gene segment (or one V and one J segment in the light chain). As there are multiple copies of each type of gene segment, and different combinations of gene segments can be used to generate each immunoglobulin variable region, this process generates a huge number of antibodies, each with different paratopes, and thus different antigen specificities. The rearrangement of several subgenes (i.e.

Individual PH domains possess specificities for phosphoinositides phosphorylated at different sites within the inositol ring, e.g., some bind phosphatidylinositol (4,5)-bisphosphate but not phosphatidylinositol (3,4,5)-trisphosphate or phosphatidylinositol (3,4)-bisphosphate, while others may possess the requisite affinity. This is important because it makes the recruitment of different PH domain containing proteins sensitive to the activities of enzymes that either phosphorylate or dephosphorylate these sites on the inositol ring, such as phosphoinositide 3-kinase or PTEN, respectively. Thus, such enzymes exert a part of their effect on cell function by modulating the localization of downstream signaling proteins that possess PH domains that are capable of binding their phospholipid products.

Serine/threonine-protein phosphatase 2A regulatory subunit B' is an enzyme that in humans is encoded by the PPP2R4 gene. Protein phosphatase 2A is one of the four major Ser/Thr phosphatases and is implicated in the negative control of cell growth and division. Protein phosphatase 2A holoenzymes are heterotrimeric proteins composed of a structural subunit A, a catalytic subunit C, and a regulatory subunit B. The regulatory subunit is encoded by a diverse set of genes that have been grouped into the B/PR55, B'/PR61, and B/PR72 families. These different regulatory subunits confer distinct enzymatic specificities and intracellular localizations to the holozenzyme.

Serine/threonine-protein phosphatase 2A regulatory subunit B subunit alpha is an enzyme that in humans is encoded by the PPP2R3A gene. Protein phosphatase 2 (formerly named type 2A) is one of the four major Ser/Thr phosphatases and is implicated in the negative control of cell growth and division. Protein phosphatase 2 holoenzymes are heterotrimeric proteins composed of a structural subunit A, a catalytic subunit C, and a regulatory subunit B. The regulatory subunit is encoded by a diverse set of genes that have been grouped into the B/PR55, B'/PR61, and B/PR72 families. These different regulatory subunits confer distinct enzymatic specificities and intracellular localizations to the holozenzyme.

All RBPs can bind to RNA depends on different specificities and affinities. RBPs contain at least one RNA-binding domains and usually they have multiple binding domains. RNA-binding domain (RBD, also known as RNP domain and RNA recognition motif, RRM), K-homology (KH) domain (type I and type II), RGG (Arg-Gly-Gly) box, Sm domain; DEAD/DEAH box, zinc finger (ZnF, mostly C-x8-X-x5-X-x3-H), double stranded RNA-binding domain (dsRBD), cold- shock domain; Pumilio/FBF (PUF or Pum-HD) domain, and the Piwi/Argonaute/Zwille (PAZ) domain have been well characterized. RBPs are constructed by multiple binding domains.

Selective microfluidics-based ligand enrichment followed by sequencing (SMiLE- seq) is a technique developed for the rapid identification of DNA binding specificities and affinities of full length monomeric and dimeric transcription factors in a fast and semi-high-throughput fashion. SMiLE-seq works by loading in vitro transcribed and translated “bait” transcription factors into a microfluidic device in combination with DNA molecules. Bound transcription factor-DNA complexes are then isolated from the device, which is followed by sequencing and sequence data analysis to characterize binding motifs. Specialized software is used to determine the DNA binding properties of monomeric or dimeric transcription factors to help predict their in vivo DNA binding activity.

Elucidating the regulatory mechanisms used to govern essential cellular processes is one of the most intensely studied branches of science. Cellular regulatory networks can be incredibly complex, and often involve the coordination of multiple processes that begin with the modulation of gene expression. The binding of transcription factor molecules to DNA, either alone or in combination with other transcription factors, is used to control gene expression in response to both intra- and extracellular stimuli. Characterizing the binding mechanisms and specificities of transcription factors to specific regions of DNA – and identifying these transcription factors – is a fundamental component of the process of resolving cellular regulatory dynamics.

Visualisation methods such as electron microscopy (SEM and TEM) and atomic force microscopy (AFM) analysis allow visualisation of the nano world. Further nanotoxicology studies will require precise characterisation of the specificities of a given nano-element: size, chemical composition, detailed shape, level of aggregation, combination with other vectors, etc. Above all, these properties would have to be determined not only on the nanocomponent before its introduction in the living environment but also in the (mostly aqueous) biological environment. There is a need for new methodologies to quickly assess the presence and reactivity of nanoparticles in commercial, environmental, and biological samples since current detection techniques require expensive and complex analytical instrumentation.

In education, the party advocates the creation of a National High Council of Education to correct imperfections which in his line, undermined Algeria's schools become an experimentation testing ground. This council would consist of executives and scientific skills that would have the task of promoting the sector of education and teaching, and promote the obtaining of an educational product quality. Towards the youth, he defended a replacement of the National Support Agency for youth employment (ANSEJ) through the creation of investment banks who do not practice usury and according to the specificities of each region. In management, the party advocates a modernization of the administration through the establishment of e-governance.

On 21 November 2005, the Northern Dimension ministerial meeting held in Brussels approved by unanimity The Guidelines for the Development of a Political Declaration and Policy Framework Document for Northern Dimension Policy from 2007. These guidelines were the agreed basis to draft in 2006 new basic Northern Dimension documents that opened for a new phase of this policy. For example, the parties agreed that the Northern Dimension is a shared policy and that it will be the regional expression in the North of Europe of the EU / Russia Common Spaces although keeping its own specificities i.e. full membership of Norway and Iceland, special concern about environment and health issues, protection of indigenous peoples, etc.

The molecular basis of the action of these enzymes consists in binding of nicotinamide adenine dinucleotide (NAD), splitting NAD into its ADP-ribose and nicotinamide components, and transferring the ADP-ribose moiety to a specific residue on to a protein substrate, often of eukaryotic origin. All the toxins of this family share a highly conserved glutamate, which is the catalytic residue critical for the NAD-glycohydrolase activity. ADP-ribosyltransferase toxins have distinct substrate specificities and variable pathophysiological properties and can be subdivided into four subfamilies: diphtheria-like toxins, cholera- like toxins, binary toxins and C3-like exoenzymes. C3-like exoenzymes unlike other ADP-ribosyltransferase toxins do not require a specific cell-surface binding translocation component for cell entry.

While queer IR incorporates transgender individuals in its expanded scope, some argue its emphasis on sexuality fails to adequately capture transgender experiences. Susan Stryker contests that queer theory's approach merely treats the ‘T’ in LGBT as another, detached genre of sexual identity, “rather than perceived, like race or class, as something that cuts across existing sexualities, revealing in often unexpected ways the means through which all identities achieve their specificities.” While queer theoretical spaces remain friendly to transgender work, Stryker argues that ‘queer’ often acts as code for ‘gays’ or ‘lesbians,’ implicitly excluding transgender issues by privileging sexual orientations and identities. This leads Stryker to advocate that transgender studies follows its own trajectory.

Galactose-3-O-sulfotransferase 3 is an enzyme that in humans is encoded by the GAL3ST3 gene. This gene encodes a member of the galactose-3-O-sulfotransferase protein family. The product of this gene catalyzes sulfonation by transferring a sulfate group to the 3' position of galactose in N-acetyllactosamine in both type 2 (Gal-beta-1-4GlcNAc-R) oligosaccharides and core-2-branched O-glycans, but not on type 1 or core-1-branched structures. This gene, which has also been referred to as GAL3ST2, is different from the GAL3ST2 gene located on chromosome 2 that encodes a related enzyme with distinct tissue distribution and substrate specificities, compared to galactose-3-O-sulfotransferase 3.

On the transnational or regional level, the anti-violence movements also deploy different strategies based on the specificities of their cultures and beliefs in their particular regions. On this level, the activist movements are known as "transnational feminist networks" or TFNs. The TFNs have a significant effect, like the autonomous movements on the national level, in shaping sets of policies as well pushing for the recognition and inclusion of language of VAW in the United Nations human rights mechanisms: the international human rights agreements. Their activities are ranging from lobbying the policy makers; organizing demonstrations on the local and regional levels; to creating institutional pressure that could push for changes in the international institutional measures.

In the Frappe series, Pasquali experiments with neoprene, assembling layers oyyf the material into spirals which are then mounted onto wooden panels or metal nets. Works from the Bristles series consist of plastic broom bristles assembled into wooden containers and arranged to form a soft, compact surface. More recently, the artist has been experimenting with long, uncut, plastic bristles, in particular with the site-specific installation Francesca Pasquali for Salvatore Ferragamo travelling to Milan and London in 2016. Pasquali’s work is also characterised by a sensitivity to materiality, experimenting with various materials including plastic, marble and bread and the artist often works to commissions, marrying the specificities of her practice with the particularities of the request.

The main purpose of the European Alliance of Cities and Regions for Roma Inclusion is – through its participating cities and regions, in coordination with the respective national governments and while taking into account the specificities of each country – to favour projects and policies for RomaThe term "Roma" used at the Council of Europe refers to Roma, Sinti, Kale and related groups in Europe, including Travellers and the Eastern groups (Dom and Lom), and covers the wide diversity of the groups concerned, including persons who identify themselves as Gypsies. inclusion at local and regional level. In this regard, a strategic guideline for 2014-2020 has been approved by the Congress Bureau in Strasbourg on 8 September 2014.

When dealing with multiple architecture description languages, propagating changes may be a complex task; such a task is inevitable and requires to be managed by a dedicated approach. In DUALLy, the interoperability among various architecture description languages is ensured via model transformation techniques. Instead of creating a point-to-point relationship among all languages, DUALLY defines the transformations among architecture description languages by passing through A0, which is a core set of architectural concepts defined as generally as possible (to potentially represent and support any kind of architectural representation) and extensible (in order to add domain specificities). In other words, A0 acts as a bridge among the different architectural languages to be related together.

Later during infection, another antitermination protein pQ acts specifically on the late transcription unit, to allow its transcription to continue past a termination sequence. The different specificities on pN and pQ establish an important general principle: RNA polymerase interacts with transcription units in such a way that an ancillary factor can sponsor antitermination specifically for some transcripts. Termination can be controlled with the same sort of precision as initiation. The antitermination activity of pN is highly specific, but the antitermination event is not determined by the terminators tL1 and tR1; the recognition site needed for antitermination lies upstream in the transcription unit, that is, at a different place from the terminator site at which the action eventually is accomplished.

For example, twenty- one unique modA alleles have been identified in Haemophilus influenzae; Neisseria species contain seven modB alleles; and Helicobacter pylori contains seventeen modH alleles. Individual strains of Neisseria gonorrhoeae and Neisseria meningitidis can contain multiple, independently switching mod genes; for example, N. gonorrhoae can contain both modA and modB genes002C and individual N. meningitidis strains that contain modA, modB and modD have been identified. A phasevarion controlled by a methyltransferase associated with a Type I R-M system has been identified and studied in Streptococcus pneumoniae. This phase-variable methyltransferase switches between six different methyltransferase specificities by shuffling between multiple, variable copies of the specificity subunit, hsdS, that dictates the sequence to be methylated.

SCOPE was then used to construct a synthetic enzyme lineage, which was biochemically characterized to recapitulate the evolutionary divergence of two modern day enzymes. The rapid evolvability of chemical diversity in terpene synthases were demonstrated through processes akin to both Darwinian gradualism and saltation: some mutational pathways show steady, additive changes, whereas others show drastic jumps between contrasting product specificities with single mutational steps. Further, a metric was devised to describe the chemical distance of mutational steps to derive a chemical-based phylogeny relating sequence variation to chemical output. These examples establish SCOPE as a standardized method for the construction of synthetic gene libraries from close or distantly related parental sequences to identify functional novelty among the encoded proteins.

The more McLaren began engaging in the work of Marx, and meeting social activists driven by Marxist anti-imperialist projects throughout the Americas, he no longer believed that the work on "radical democracy" convincingly demonstrated that it was superior to the Marxist problematic. It appeared to McLaren that, in the main, such work had despairingly capitulated to the inevitability of the rule of capital and the regime of the commodity. That work, along with much of the work in post-colonialist criticism, appeared to McLaren as too detached from historical specificities and basic determinations. McLaren believed that Marxist critique more adequately addressed the differentiated totalities of contemporary society and their historical imbrications in the world system of global capitalism.

Through this practice, they develop a certain disposition for social action that is conditioned by their position on the field.Dominant/dominated and orthodox/heterodox are only two possible ways of positioning the agents on the field; these basic binary distinctions are always further analysed considering the specificities of each field This disposition, combined with every other disposition the individual develops through their engagement with other fields operating within the social world, will eventually come to constitute a system of dispositions, i.e. habitus: lasting, acquired schemes of perception, thought and action. Habitus is somewhat reminiscent of some preexisting sociological concepts, such as socialization, though it also differs from the more classic concepts in several key ways.

This research was later developed and completed by the IAURIF (called IAU nowadays). In 1986, she opens and manages the Mostra gallery in Paris. Surrounded by artists, designers and architects such as Jean Nouvel, Rem Koolhaas, Christian de Portzamparc, François Rouan, Pierre Buraglio, Arata Isozaki, Bernar Venet and Peter Klasen, among others, she questioned the creative approach proper to architects, artists and contemporary furniture designers of that time. Consequently, through themed exhibitions, she developed a profusion of unique ideas showing very clearly the specificities of each creative field, which brought her to the headlines of many French and international magazines and put her gallery on the podium of the best Parisian galleries.

In archaea such as Thermoplasma acidophilum, all the α and all the β subunits are identical, whereas eukaryotic proteasomes such as those in yeast contain seven distinct types of each subunit. In mammals, the β1, β2, and β5 subunits are catalytic; although they share a common mechanism, they have three distinct substrate specificities considered chymotrypsin-like, trypsin-like, and peptidyl-glutamyl peptide-hydrolyzing (PHGH). Alternative β forms denoted β1i, β2i, and β5i can be expressed in hematopoietic cells in response to exposure to pro-inflammatory signals such as cytokines, in particular, interferon gamma. The proteasome assembled with these alternative subunits is known as the immunoproteasome, whose substrate specificity is altered relative to the normal proteasome.

The enzymes produced by X-linked genes AWAT1 and AWAT2 have been shown to esterify long chain alcohols to produce wax esters and is most predominantly expressed in skin. Both enzymes have dissimilar substrate specificities: AWAT1 prefers decyl alcohol (C10) and AWAT2 prefers C16 and C18 alcohols while using oleoyl-CoA as the acyl donor. However, when using acetyl alcohol as the acyl acceptor, AWAT1 prefers saturated acyl groups, while AWAT2 shows activity with all four acyl-CoAs and performs two times better with unsaturated acyl-CoAs than with saturated ones. Along with the murine wax ester synthase, AWAT1 and AWAT2 are likely the most significant contributors in wax ester production in mammals.

To guard itself from other microorganisms that live in the environment, the Cascades frog produces high concentrations of antimicrobial peptides it secretes from its skin in response to infection or stress. According to Conlon, "frogs belonging to the genus Rana represent a particularly rich source of peptides with diverse structures and specificities against micro-organisms". He began testing the frog secretions to determine whether or not the peptides would have an effect on bacteria that attack human cells. He found the chemical ranatuerin-2CSa, which is produced by R. cascadae, impeded the growth of E. coli and S. aureus in humans. These anti- infective agents give the Cascades frogs “therapeutic potential for the future”, according to Conlon.

Vessels in the head and neck may also be evaluated to look for atherosclerotic lesions that may benefit from interventions, such as carotid endarterectomy. The vasculature can be evaluated through the following imaging modalities: magnetic resonance angiography (MRA), CT angiography (CTA), and carotid ultrasonography/transcranial doppler ultrasonography. Carotid ultrasonography is often used to screen for carotid artery stenosis, as it is more readily available, is noninvasive, and does not expose the person being evaluated to radiation. However, all of the above imaging methods have variable sensitivities and specificities, making it important to supplement one of the imaging methods with another to help confirm the diagnosis (for example: screen for the disease with ultrasonography, and confirm with CTA).

Thus, at any given stage of disease or rejection, the T-cell response is likely to be heterogenic, involving multiple TCR specificities, leading to difficulties in prescribing the antigen, dosing, and timing of administration required to induce tolerance. While antigen-specific tolerance induction is an attractive strategy,Chatenoud, L. & Bluestone, J.A. “CD3-specific antibodies: a portal to the treatment of autoimmunity”, Nature Reviews Immunology 20 July 2007. it’s limited by a lack of knowledge, and because of its stringent requirements, a slightly broader approach is more practical. SCIIT attempts to occupy the middle ground of immuno-therapeutics by avoiding the dangerous side effects of general immunosuppressive therapy, while alleviating the stringent demands of antigen-specific tolerance induction.

The Kinshasa Convention is the most recent small arms control and disarmament legal instrument elaborated within the United Nations framework. This Convention, which addresses the security, legal, institutional and cultural specificities of the Central African subregion, demonstrates the eleven UNSAC countries' willingness to establish a coherent subregional strategy to act collectively against illicit arms and ammunition. The mobilization of the eleven Central African countries to negotiate this arms control and disarmament instrument contributes also to a significant confidence-building measure amongst countries, the majority of which had been at war with each other. The Convention's scope is broad and takes into account the most recent developments in global and regional initiatives aimed at combating illicit small arms and light weapons.

While the number of Pcdhs isoforms pales in comparison to the number of Dscam1 isoforms, hetero-oligomerization of Pcdhs markedly increases the number of discrete binding specificities encoded by the locus. Pcdhs are required for self-avoidance To seek roles of Pcdh-γs in self- avoidance, Lefebvre et al. (2012) focused on a retinal interneuron, the starburst amacrine cell (SAC), which expresses Pcdh-γs and exhibits dramatic dendritic self-avoidance. They used a Cre-Lox system to delete all the variable domains of the Pcdh-γ locus in the developing retina and verified that dendrites arising from a single SAC frequently crossed each other and sometimes formed loose bundles, similarly to the removal of Dscam1 from da neurons (Figure 8).

Assessing the extent to which Gandhi's ideas of satyagraha were or were not successful in the Indian independence struggle is a complex task. Judith Brown has suggested that "this is a political strategy and technique which, for its outcomes, depends of historical specificities."Brown, Judith M., "Gandhi and Civil Resistance in India, 1917–47: Key Issues", in Adam Roberts and Timothy Garton Ash (eds.), Civil Resistance and Power Politics: The Experience of Non- violent Action from Gandhi to the Present, Oxford University Press, 2009 p. 57 The view taken by Gandhi differs from the idea that the goal in any conflict is necessarily to defeat the opponent or frustrate the opponent's objectives, or to meet one's own objectives despite the efforts of the opponent to obstruct these.

However, the goal of the Shah has been partially been accomplished since extraterritoriality has not been abolished. By going to Europe, Naser al-Din Shah also intended to pay attention to the specificities of European civilization and to the factors contributing to their success and superiority. He would then be able to inform the Persian audience and to apply some models and ideas to his country. In an announcement, the Shah expressively asserted that one of the main goal for travelling to Europe was to collect "all information and gathering experiences, which can be valuable for the Persian government and nation". Back home, the Shah indeed tried to improve Persia’s railway and telegraph by taking European railways and telegraph infrastructures as a model.

Communities exercise competences only within linguistically determined geographical boundaries, originally oriented towards the individuals of a community's language: culture (including audiovisual media), education, the use of the relevant language. Extensions to personal matters less directly attributed to the language comprise health policy (curative and preventive medicine) and assistance to individuals (protection of youth, social welfare, aid to families, immigrant assistance services, etc.) Regions have authority in fields connected with their territory in the widest meaning of the term, thus relating to the economy, employment, agriculture, water policy, housing, public works, energy, transport, the environment, town and country planning, nature conservation, credit, and foreign trade. They supervise the provinces, municipalities and intercommunal utility companies. In several fields, the different levels each have their own say on specificities.

Multimeric forms of Affimer proteins have been generated and shown to yield titrimetric volumes in the range of 200–400 mg/L under small scale culture using bacterial host systems. Multimeric forms of Affimer proteins with the same target specificity provided avidity effects in target binding, while fusion of different Affimer proteins with different target specificities would enable multi-specific affinity proteins. Many different tags and fusion proteins, such as fluorophores, single-stranded DNA, His, and c-Myc tags can be easily conjugated to Affimer proteins. Specific cysteine residues can be introduced to the protein to allow thiol chemistry to uniformly orient Affimer proteins on a solid support for the purposes of increasing target capture in ligand binding assays and biosensors.

Out of 16 Cpf1-family proteins, scientists identified two candidate enzymes from Acidaminococcus and Lachnospiraceae, with efficient genome-editing activity in human cells.Genome- wide specificities of CRISPR-Cas Cpf1 nucleases in human cells by Benjamin P Kleinstiver, Shengdar Q Tsai, Michelle S Prew, Nhu T Nguyen, Moira M Welch, Jose M Lopez, Zachary R McCaw, Martin J Aryee & J Keith Joung in "Nature Biotechnology" 34, 869–874 (2016) doi:10.1038/nbt.3620 Published online 27 June 2016 Cpf1 was introduced with features that SpCas9 is lacking. Cpf1 requires only a 42-nt short CRISPR RNA (crRNA) to find its target, instead of the ~100-nt guide RNA for SpCas9, and it recognizes a protospacer-adjacent motif (PAM) that is 5′ instead of 3′ of the target site.

The work also traces the historic specificities of the Greek socio- economic formation and argues that one of the most important aspects of this formation is the landownership regime, which constitutes a Greek historic peculiarity and which was to play a decisive role both to the economic developments of the period and the social stratification of the Greek society. The work also focus on a specific sector of the post-war Greek economy, the house-building production, which is characterized by small scale of production. The work reveals that it functioned as an economic mechanism distributing incomes to the benefit of the lower and middle strata of the population. This analysis grasps, among other things, the importance of small- scale production for the distribution of the social wealth to wider social strata.

Ferry docked at Konak ferry terminal Karataş The name "Konak" was previously used for İzmir's historic core neighborhood, as well as for its key central square (Konak Square – Konak Meydanı). For example, Karşıyaka along the opposing northern shore did not always consider itself as an integral part of İzmir, or in any case, had marking specificities and points of rivalry. Administrative history of Konak started in 1983–1984 when the steps towards the constitution of a Metropolitan Municipality of İzmir, itself divided into districts, were taken. In 1987, the territory of former district of central İzmir of was renamed the district of Konak (with the exception of its former dependency of Buca, which was turned into a separate district), and the name İzmir implies the entire metropolitan area since then.

Both proteins are encoded on the same operon within the bacterial genome. Unlike many eukaryotic proteasomes, which have several different peptide substrate specificities, hslV has a specificity similar to that of chymotrypsin; hence it is inhibited by proteasome inhibitors that specifically target the chymotrypsin site in eukaryotic proteasomes.Rohrwild M, Coux O, Huang HC, R P Moerschell RP, Yoo SJ, Seol JH, Chung CH, Goldberg AL. (1996). HslV-HslU: A novel ATP-dependent protease complex in Escherichia coli related to the eukaryotic proteasome. Proc Natl Acad Sci USA 93(12): 5808–5813 Although the HslVU complex is stable on its own, some evidence suggests that the complex is formed in vivo in a substrate-induced manner due to a conformational change in the hslU-substrate complex that promotes hslV binding.

In the Climate Summit of 2015, Colombia, Germany, Norway, and the United Kingdom signed a Joint Declaration to strengthen collaboration on the climate and forests in Colombia. Norway has committed to a total of 1.8 billion Norwegian crones to Colombia within 2020. The project has been adopted as a national policy and priority in the new National Development Plan 2014-2018. The inclusion of the Program in this PND meant that for the first time in the country there is a framework for development policy that promotes green growth strategies with concrete goals of education of consequences of deforestation and goals of conservation and sustainable use for the Amazon region, offering the opportunity to influence national policies by inserting specificities of the Amazon region that help the region reduce deforestation.

1967 - The serine proteases are a historically very important group of enzyme structures, because collectively they illuminated catalytic mechanism (in their case, by the Ser-His-Asp "catalytic triad"), the basis of differing substrate specificities, and the activation mechanism by which a controlled enzymatic cleavage buries the new chain end to properly rearrange the active site. The early crystal structures included chymotrypsin (PDB file 2CHA), chymotrypsinogen (PDB file 1CHG), trypsin (PDB file 1PTN), and elastase (PDB file 1EST). They also were the first protein structures that showed two near- identical domains, presumably related by gene duplication. One reason for their wide use as textbook and classroom examples was the insertion-code numbering system (hated by all computer programmers), which made Ser195 and His57 consistent and memorable despite the protein-specific sequence differences.

Retinyl ester hydrolysis requires the presence of bile salts that serve to solubilize the retinyl esters in mixed micelles and to activate the hydrolyzing enzymes Noy, N. (2006) "Vitamin A", "Biochemical, Physiological, & Molecular Aspects of Human Nutrition", M. H. Stipanuk 2nd Ed. Several enzymes that are present in the intestinal lumen may be involved in the hydrolysis of dietary retinyl esters. Cholesterol esterase is secreted into the intestinal lumen from the pancreas and has been shown, in vitro, to display retinyl ester hydrolase activity. In addition, a retinyl ester hydrolase that is intrinsic to the brush-border membrane of the small intestine has been characterized in the rat as well as in the human. The different hydrolyzing enzymes are activated by different types of bile salts and have distinct substrate specificities.

In patients with multiple sclerosis (MS), disease-associated myelin-specific T cells from the blood are predominantly co-stimulation- independent effector-memory T cells that express high numbers of Kv1.3 channels. T cells in MS lesions in postmortem brain lesions are also predominantly effector-memory T cells that express high levels of the Kv1.3 channel. In children with type-1 diabetes mellitus, the disease-associated insulin- and GAD65-specific T cells isolated from the blood are effector- memory T cells that express high numbers of Kv1.3 channels, and the same is true of T cells from the synovial joint fluid of patients with rheumatoid arthritis. T cells with other antigen specificities in these patients were naive or central memory T cells that upregulate the KCa3.1 channel upon activation.

In order to take into account the specificities of this surface, new tactics and new techniques (such as the Indian dribble) have been developed and new rules have been introduced in order to control these new techniques. Regarding the evolution of the hockey player material, the sticks have changed shape, with the bent head at the bottom, which used to be about 15 centimetres long, becoming much stubbier. The extra length was no longer necessary, as the ball travelled much straighter on the flatter synthetic fields. The shorter length made playing the ball with the "backhand" (playing with the head of the stick to the player's left, with the head rotated 180 degrees from its usual position) much easier, increasing the speed with which this tactic, often used for evasive manoeuvres, could be used.

Due to the sensitivity of materials to the specificities in the irradiation conditions, such as the α-particle generation/dpa ratio at damage levels above 15 dpa per year of operation under temperature controlled conditions, material tests require the neutron source to be comparable to a fusion reactor environment. In steels, the 54Fe(n,α)51Cr and 54Fe(n,p)54Mn reactions are responsible for most of the protons and α-particles produced, and these have an incident neutron energy threshold at 0.9 MeV and 2.9 MeV respectively. Therefore, conventional fast fission reactors, which produce neutrons with an average energy around 1-2 MeV, cannot adequately match the testing requirements for fusion materials. In fact the leading factor for embrittlement, the generation of α-particles by transmutation, is far from realistic conditions (actually around 0.3 appm He/dpa).

The Arbëreshe identity, tempered in a foreign land (te dheu i huaj), seals its strong indigenous character. The cornerstones of the community are: the Albanian language, the Byzantine rite, traditional customs and customs, history. The social component was the endogenous force of Piana degli Albanesi: the intelligentsia Arbëreshe, the priests in the first place and exponents of political and cultural life, through institutions and the work of many illustrious men, worked with zeal to defend the peculiarities identity. The maintenance of the Albanian status, as in every identity reality, is confronted daily with the socio-cultural transformism and if once ignoring each other between Albanians and Sicilians was the way to preserve each one's own specificities, the current territorial dynamics not they allow it to the extent that the world-system is expressed through relations from the local to the supra-local.

MsbA is a multi- drug resistant (MDR) ABC transporter and possibly a lipid flippase. It is an ATPase that transports lipid A, the hydrophobic moiety of lipopolysaccharide (LPS), a glucosamine-based saccharolipid that makes up the outer monolayer of the outer membranes of most gram-negative bacteria. Lipid A is an endotoxin and so loss of MsbA from the cell membrane or mutations that disrupt transport results in the accumulation of lipid A in the inner cell membrane resulting to cell death. It is a close bacterial homolog of P-glycoprotein (Pgp) by protein sequence homology and has overlapping substrate specificities with the MDR-ABC transporter LmrA from Lactococcus lactis. MsbA from E. coli is 36% identical to the NH2-terminal half of human MDR1, suggesting a common mechanism for transport of amphiphatic and hydrophobic substrates.

The IL-17 receptor family consists of five, broadly distributed receptors (IL-17RA, B, C, D and E) that present with individual ligand specificities. Within this family of receptors, IL-17RA is the best-described. IL-17RA binds both IL-17A and IL-17F and is expressed in multiple tissues: vascular endothelial cells, peripheral T cells, B cell lineages, fibroblast, lung, myelomonocytic cells, and marrow stromal cells. Signal transduction for both IL-17A and IL-17F requires the presence of a heterodimeric complex consisting of both IL-17RA and IL-17RC and the absence of either receptor results in ineffective signal transduction. This pattern is reciprocated for other members of the IL-17 family such as IL-17E, which requires an IL-17RA-IL-17RB complex (also known as IL-17Rh1, IL-17BR or IL-25R) for effective function.

Another method uses 2-finger modules to generate zinc finger arrays with up to six individual zinc fingers. The Barbas Laboratory of The Scripps Research Institute used phage display to develop and characterize zinc finger domains that recognize most DNA triplet sequences while another group isolated and characterized individual fingers from the human genome. A potential drawback with modular assembly in general is that specificities of individual zinc finger can overlap and can depend on the context of the surrounding zinc fingers and DNA. A recent study demonstrated that a high proportion of 3-finger zinc finger arrays generated by modular assembly fail to bind their intended target with sufficient affinity in a bacterial two-hybrid assay and fail to function as zinc finger nucleases, but the success rate was somewhat higher when sites of the form GNNGNNGNN were targeted.

The METEO System was in operational use at Environment Canada from 1982 to 2001. It stems from a prototype developed in 1975-76 by the TAUM Group, known as TAUM-METEO. The initial motivation to develop that prototype was that a junior translator came to TAUM to ask for help in translating weather bulletins at Environment Canada. Since all official communications emanating from the Canadian government must be available in French and English, because of the Official Languages Act of 1969, and weather bulletins represent a large amount of translation in real time, junior translators had to spend several months producing first draft translations, which were then revised by seniors. That was a difficult and tedious job, because of the specificities of the English and French sublanguages used, and not very rewarding, as the lifetime of a bulletin is only 4 hours.

However, under Icelandic law, it is not the Government but the Icelandic Parliament which decides to end negotiations. On 13 June, Iceland's Foreign Minister Gunnar Bragi Sveinsson informed the European Commission that the newly elected government intended to "put negotiations on hold". European Commission President Manuel Barroso responded on 16 July 2013 by requesting that the new Icelandic Prime Minister make a decision on the continuation of their accession bid "without further delay", and stressed that the EU remained "committed to continue the accession negotiations process, which I'm certain could address Iceland's specificities". In August 2013 the Icelandic government revealed that it had received a legal opinion that the 2009 Parliamentary vote did not oblige it to continue accession negotiations with the EU. In light of this, the Foreign Ministry stated that it had "decided to consider dissolving the negotiation committee".

"The passage to postindustrial society takes place when investment results in the production of symbolic goods that modify values, needs, representations, far more than in the production of material goods or even of 'services'. Industrial society had transformed the means of production: post-industrial society changes the ends of production, that is, culture. (…) The decisive point here is that in postindustrial society all of the economic system is the object of intervention of society upon itself. That is why we can call it the programmed society, because this phrase captures its capacity to create models of management, production, organization, distribution, and consumption, so that such a society appears, at all its functional levels, as the product of an action exercised by the society itself, and not as the outcome of natural laws or cultural specificities" (Touraine 1988: 104).

Slavs and Tatars' exhibitions, books, printed matter and lecture-performances draw upon the stylistic palette of popular culture, spiritual and esoteric traditions, oral histories, modern myths, as well as scholarly research. Nicholas Cullinan in Artforum describes Slavs and Tatars as "the most cosmopolitan of collectives, where a geopolitics of globe- trotting allows their shape-shifting projects and concerns to continuously cross-pollinate divergent, and sometimes diametrically opposed, cultural specificities.” The artists’ work can be organized according to cycles of research, each on a different theme or topic, from alphabet politics (Language Arts), to medieval advice literature (Mirrors for Princes) to an investigation of syncretism (Not Moscow Not Mecca). H.G. Masters in Asia Art Pacific writes: "Beginning with the collective’s name, everything related to Slavs and Tatars is about building connections between seemingly disparate subjects—whether places, histories or ideologies.

This debate has direct consequences on the assessment of the housecarls' specificities, and whether or not they were an elite troop. For instance, Charles Oman, in his book The Art of War in the Middle Ages (1885), states that the main advantage of the housecarls at Hastings were their esprit de corps. This view, still widely held today, mainly stems from Svend Aggesen's 12th-century description of Cnut's housecarls as a group characterized by a strict code (see above); Aggesen having been used as a main source by L.M. Larson's The King's Household in England Before the Norman Conquest (1902). However, more recently, historian Nicholas Hooper criticised Larson and stated that "it is time to debunk the housecarl"; according to Hooper, housecarls were not in effect distinguishable from Saxon thegns, and were mainly retainers who received lands or pay (or both), but without being really a standing army.

PA is a vital cell lipid that acts as a biosynthetic precursor for the formation (directly or indirectly) of all acylglycerol lipids in the cell. In mammalian and yeast cells, two different pathways are known for the de novo synthesis of PA, the glycerol 3-phosphate pathway or the dihydroxyacetone phosphate pathway. In bacteria, only the former pathway is present, and mutations that block this pathway are lethal, demonstrating the importance of PA. In mammalian and yeast cells, where the enzymes in these pathways are redundant, mutation of any one enzyme is not lethal. However, it is worth noting that in vitro, the various acyltransferases exhibit different substrate specificities with respect to the acyl-CoAs that are incorporated into PA. Different acyltransferases also have different intracellular distributions, such as the endoplasmic reticulum (ER), the mitochondria or peroxisomes, and local concentrations of activated fatty acids.

The Language Act was based upon the principle of Russian/Estonian bilingualism which requires that the holders of certain jobs be proficient in Estonian in addition to Russian. The Act impacted those who were employed in positions that involve communication with the public or subordinates in state administration and in most cases required an elementary level of knowledge of around 800 words, impacting about 12% of the Russian speaking population. The Language Inspectorate was thus established to supervise the implementation of the Language Act. Later, new Language Acts were adopted, in 1995 and 2011.Language Act In 2006, the European Commission against Racism and Intolerance has noted that "it appears that no system has been put in place to monitor the Language Inspectorate's implementation of the Law on Language" and that "the Language Inspectorate does not appear to take into account regional specificities when applying the Language Law".

Cellular studies of self-avoidance imply that any underlying molecular mechanism must enforce robust and selective contact-dependent cell surface recognition only between sister branches, and must link recognition to changes in growth cone behavior. Recent studies to define the molecular basis of contact-dependent homotypic interactions led to the identification of two large families of cell-surface proteins encoded by the Drosophila Down syndrome cell adhesion molecule 1 (Dscam1) locus and the clustered protocadherin (Pcdh) loci in mammals. These proteins, with diverse extracellular domains, and shared cytoplasmatic presumptive intracellular signaling domains, are able to provide diverse recognition specificities to a vast array of different neurites, endowing neurons with a unique cell-surface identity that allows neurons to distinguish self from non-self. Additional self-surface receptors implicated in self- avoidance include the immunoglobulin superfamily member Turtle, which functions in some Drosophila da neurons to enforce terminal branch spacing.

" However, while the boarding schools were undeniably detrimental to Native Americans, their efforts to assimilate and erase tribal identities through forced "education" were unfulfilled, since "instead of replacing their students' Indian identity with an American one as planned, the schools reinforced it while creating a pan-Indian identity alongside other tribal identities." The emergence of pan-Indianism as an effect of the off- reservation boarding schools unified Native American resistance to colonialism and served as an important "tool for future unity and cohesion among Indians." Native Americans have since resisted further detribalization through the institution of tribal colleges and vocational education programs which do not adopt "an assimilationist or a detribalization approach" but rather function in encouraging "revitalization, as a retribalization process serving Indian communities and their members." Retribalization may function as a means of perpetuating "the development, and the revitalization of tribal linguistic and cultural specificities through educational programs.

The Barbas Laboratory of The Scripps Research Institute used phage display to develop and characterize zinc finger domains that recognize most DNA triplet sequences while another group isolated and characterized individual fingers from the human genome. A potential drawback with modular assembly in general is that specificities of individual zinc finger can overlap and can depend on the context of the surrounding zinc fingers and DNA. A recent study demonstrated that a high proportion of 3-finger zinc finger arrays generated by modular assembly fail to bind their intended target with sufficient affinity in a bacterial two-hybrid assay and fail to function as zinc finger nucleases, but the success rate was somewhat higher when sites of the form GNNGNNGNN were targeted. A subsequent study used modular assembly to generate zinc finger nucleases with both 3-finger arrays and 4-finger arrays and observed a much higher success rate with 4-finger arrays.

The political scope of the Mediterranean Commission establishes UCLG as the largest framework for direct political exchanges between local elected representatives in the Mediterranean respecting a North-South balance that undertakes to: \- Promote local and regional autonomy and the institutional reinforcement of local authorities South and East of the Mediterranean, as well as their national networks or associations. To this end, the Commission favors structuring local authorities through its support to national associations of elected officials and local authorities of the South or by fostering their creation. \- Assure direct exchanges between the many different actors on common issues at Mediterranean scale, for example, the organization of the Permanent Forum of Local and Regional Authorities of the Mediterranean, an opportunity for dialogue and a special occasion to amplify the voice of Mediterranean local authorities and to allow exchanges between Mediterranean and non-Mediterranean politicians and actors. \- Develop decentralized cooperation and initiatives advocating common values that respect Mediterranean specificities.

Bangladesh is quite religiously homogeneous in comparison to West Bengal. The Muslim population in Bangladesh is over 134.8 million in 2011, which makes up 90% of the population in the country, while Hinduism is the second largest religious affiliation in Bangladesh, with around 12.5 million people identifying themselves as Hindus making up about 8.5% of the total population according to the 2011 census. West Bengal is quite religiously diverse in comparison to Bangladesh, with regional cultural and religious specificities. As of 2011, Hinduism is the most common religion in West Bengal, with adherents representing 70.54% of the total population, while Muslims are the second-largest community as well as the largest minority group, comprise 27.01% of the total population of the state. The Hindu population of West Bengal is 64,385,546 ,while the Muslim population is 24,654,825, according to the 2011 census. This figures give a population density of 1003.9/km2; making it among the most densely populated areas in the world.World Bank Development Indicators Database, 2006.

There is a continuum that reveals several aspects: greater or lesser education, greater or lesser exposure to Portuguese, greater or lesser frequency in Portuguese usage, etc. There is no institution that regulates the usage of Portuguese in Cape Verde. Nevertheless, there are some empiric concepts about what is "correct" or "incorrect" concerning the way of speaking, resulting from: # consensual models among people that are the more educated and/or more exposed to Portuguese; # consensual models among scholars, language teachers, etc. # when some linguistic phenomena occur in a systematic and regular way, they are no longer considered deviance to the standard, but rather a genuine expression of a regional community; Another interesting phenomenon is that, if by one side the Portuguese in Cape Verde has developed some specificities, on the other side, during the years of colonization the paradigmatic models were from European Portuguese, and as of today, the reference works (grammars, dictionaries, school manuals, etc.) are from Portugal.

Other Modernities studies three generations of female silk workers in a factory in Hangzhou, comparing the social attitudes of each generation - those who entered work during the Chinese Communist Revolution, those who grew up during the Cultural Revolution, and those who grew up during the reign of Deng Xiaoping. Emily Chao, reviewing the book for Anthropological Quarterly, described it as "a theoretically sophisticated yet broadly accessible account which combines an analysis of narrative based on cultural and historical specificities, and on the politics of representation, with a reflexive interrogation of western representations of Chinese women and China; beginning with views formerly held by Rofel herself". Mary Gallagher, in The China Journal, took issue with a lack of coverage of labour issues, saying that "Wage differentials, differences in welfare benefits between contract and permanent workers, and the implementation of new incentive policies, for example, seem from Rofel's narrative to play little role in the way workers view their work, their fellow workers, or factory management".

Under Henry J. Eder's stewardship (1965–2008), Manuelita's standing in Colombia's sugar sector in terms of production was fully recovered and even surpassed when compared to Manuelita and Ingenio del Cauca's combined production levels in 1980. During this period of time, Manuelita also expanded its sugar production to ventures in Peru and Brasil, including a project named Arena Dulce, or Sweet Sand, in which nearly 2000 hectares of Peruvian desert were planted in sugarcane using vanguard drip irrigation technology adapted by Manuelita technicians to the specificities of cane cultivation and harvesting and which are producing record levels of tons of cane per hectare and percentage of sucrose in cane. Additionally, Henry Eder diversified Manuelita into other products and countries in order to diversify risk, namely shrimp (Colombia), mussels (Chile), palm oil (Colombia), ethanol (Colombia, Brazil, Peru), asparagus (Peru), and table grapes (Peru). Many details of Manuelita's business affairs from the nineteenth and early twentieth centuries are preserved at the Phanor James Eder Collection at the University of Miami, which includes a great deal of don Santiago's business correspondence.

The starting point for this Report was the observation that Arab countries have undoubtedly attained significant achievements in the advancement of women, and Arab women have made outstanding achievements in diverse fields of human activity, but much more remains to be accomplished in enabling the equitable acquisition and utilization of human capabilities and human rights by women. The Report argued for the full ratification and implementation of all the provisions of the United Nations Convention on the Elimination of All Forms of Discrimination Against Women (CEDAW), as well as a wide-ranging movement in Arab civil society that engages both women and men in the struggle to steadily expand the frontier of women's opportunities – for the benefit not only of women but for Arab society as a whole. In particular, the Report calls for the adoption of time-bound affirmative action, tailored to the specificities of each Arab society, in order to expand the participation of women in all fields of human activity. The Report argued that such measures were imperative to dismantle the structures of centuries of discrimination.

The existing urban agglomeration and architectural construction fund of the Old Core of Zemun are in themselves sources for the particular study and research on the development of methods of organizing and formation of the settlement, the construction of the object, the use of construction materials, municipal development, styles of buildings, functional, targeted and content features of architecture and spatial organization of life in general. Architectural heritage by which we mean the total physical fundus of spatial achievements, is also a source for the study of social differentiation and infrastructure of certain periods of growth, social possibilities, regional, ethnic and religious specificities, the taste of the epoch, and many other forms of life. The studies can be carried out by analyzing the material remains or continents created and saved for most of the early 18th century to today. Many buildings were preserved in their original condition, especially from the second half of the 19th century (like the Spirta House from 1855), while a smaller number of buildings from the earliest period, from the period of the first decades of the 18th century, when Zemun became part of the Austrian Empire, was only partially preserved in its original state.

Globally circulating sexual identifiers therefore risk being reductive or generalizing the geopolitical and cultural specificities of gender and sexuality. Attention must also be given to gioi tinh, the local gender/sex construct that shapes les linguistic, subjective self- determination. Unlike globally translatable, and hence accessible, labels like ‘LGBT’ or ‘lesbian’, Newton writes that gioi tinh “is more complex than either “gender” or “sexual orientation,” and holds contradictory, “multiple meanings.”Natalie Newton, “A queer political economy of ‘community’: Gender, space, and the transnational politics of community for Vietnamese lesbians (les) in Saigon” (PhD diss., University of California, Irvine, 2012), 175-6. Moreover, its discrepancies and contestations are “not a problem of translation,” but “reflect a broader conceptual disjuncture between Western and Vietnamese conceptions of gender/sex,” where the former model cannot simply be mapped onto the latter.Newton, “Queer political,” 198. As Newton discovered through her fieldwork, gioi tinh is “a complex combination of both gender and sexuality,” comprising four categories that will be briefly introduced here.Newton, “Queer political,” 183-4. Firstly, gioi tinh can refer to “biological sex [male/female] or heteronormative social gender [man/woman].”Newton, “Queer political,” 184.

Many of those active in the ANL and especially its defence "squads" were denounced as "squadist" and expelled, later going on to form Anti-Fascist Action and Red Action.Birchall, Sean, Beating The Fascists: The Untold Story of Anti-Fascist Action (London: Freedom Press, 2010) Hann, Dave and Steve Tilzey, No Retreat (Milo Books, 2003) The closure of Women's Voice in 1982, reputedly because it tried to inject feminist thinking into SWP theoretical practice rather than gaining women members for the party,Boothroyd The History of British Political Parties, p.303 was a bitterly disputed action made by the leadership,See Lindsey German Sex, Class and Socialism, Chapter 10 and Dave Isaacson "SWP and women: Countless zigs and zags over women’s oppression", Weekly Worker, No.945, 17 January 2013 a sharp debate taking place between those who believed the result would be to ignore the specificities of women's oppression, and those who believed that feminist theories were in danger of losing contact with the united interests of men and women workers. During the 1984–1985 miners' strike, the SWP's propaganda concentrated on the need for solidarity and explaining why this was not happening.

He added that despite the work's "minor" issues, he book has merit and that "It is only because the scholarship is generally so solid and the subject matter worthy of the serious attention El-Rouayheb gives it that I have been so critical of" the issues. Steven Wozniak of the Archives of Sexual Behavior argued that the author's view that the premodern relationships were not homosexuality "appears to" be undermined by his "somewhat myopic view of male- male relationships" and also that the author did not discuss relationships with adult men and women as well as a lack of discussion of "ideas from the feminist and queer theory perspectives". Wozniak concluded that "The book is well written, rich in detail, elegantly produced, but ultimately only descriptive in nature." Andrew K. T. Yip of Nottingham Trent University argued that the message, paraphrased by Yip as "No matter how tempting it is to universalize, we must exercise humility and caution; and take historical and cultural specificities seriously in our exploration of homosexuality, and indeed human sexuality", "is of great importance" "from a cross-cultural perspective particularly".