This interpretation is more consistent with the open- ended balancing style that the more liberal justices have consistently advocated. San Antonio Indep. Sch. Dist. v. Rodriquez, 411 U.S. 1, 98 (Marshall, J., dissenting) (showing "disagreement with the Court's rigidified approach to equal protection analysis"). Justice Souter, for example, argued in Washington v.
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AMG-1 (part of the AM cannabinoid series) is an analgesic drug which is a cannabinoid agonist. It is a derivative of Δ8THC with a rigidified and extended 3-position side chain. AMG-1 is a potent agonist at both CB1 and CB2 with moderate selectivity for CB1, with a Ki of 0.6 nM at CB1 vs 3.1 nM at CB2.
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It was shown that the rigidified analogue; the thiophene analogue exhibited higher free radical scavenging potential than the bosseopentaenoic acid. The results showed that by lowering the flexibility of the BPA as lead compound by incorporation thiophene ring in its structure, an increased antioxidant activity was observed. This study opens the door to investigate the relationship between the flexibility of other polyunsaturated fatty acids (PUFAs) and enhancement in the biological activity.
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O-GalNAc sugars are important in a variety of processes, including leukocyte circulation during an immune response, fertilisation, and protection against invading microbes. O-GalNAc sugars are common on membrane glycoproteins, where they help increase rigidity of the region close to the membrane so that the protein extends away from the surface. For example, the low-density lipoprotein receptor (LDL) is projected from the cell surface by a region rigidified by O-glycans. In order for leukocytes of the immune system to move into infected cells, they have to interact with these cells through receptors.
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AM-938 (part of the AM cannabinoid series) is an analgesic drug which is a cannabinoid receptor agonist. It is a derivative of HU-210 which has been substituted with a 6β-(3-hydroxyprop-1-ynyl) group. This adds a "southern" aliphatic hydroxyl group to the molecule as seen in the CP-series of nonclassical cannabinoid drugs, and so AM-938 represents a hybrid structure between the classical and nonclassical cannabinoid families, with the 6-hydroxyalkyl chain rigidified with a triple bond. This gives AM-938 a greater degree of selectivity, so while it is still a potent agonist at both CB1 and CB2, it is reasonably selective for CB2, with a Ki of 0.3nM at CB2 and 1.2nM at CB1, a selectivity of around 4x.
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AM-4030 is an analgesic drug which is a cannabinoid receptor agonist. It is a derivative of HU-210 which has been substituted with a 6β-((E)-3-hydroxyprop-1-enyl) group. This adds a "southern" aliphatic hydroxyl group to the molecule as seen in the CP-series of nonclassical cannabinoid drugs, and so AM-4030 represents a hybrid structure between the classical and nonclassical cannabinoid families, with the 6-hydroxyalkyl chain rigidified with a double bond with defined stereochemistry. This gives AM-4030 a greater degree of selectivity, so while it is still a potent agonist at both CB1 and CB2, it is reasonably selective for CB1, with a Ki of 0.7nM at CB1 and 8.6nM at CB2, a selectivity of around 12x.
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Like with examples of compound words in the political language of the 20th century—Nazi, Gestapo, Politburo, Comintern, Inprecorr, Agitprop, and many others—Orwell remarks that the Party believed that abbreviating a name could "narrowly and subtly" alter a word's meaning. Newspeak is supposed to make this effort a conscious purpose: The B words in Newspeak are supposed to sound at least somewhat nice, while also being easily pronounceable, in an attempt to make speech on anything political "staccato and monotonous" and, ultimately, mask from the speaker all ideological content. The words of the C vocabulary are scientific and technical terms that supplement the linguistic functions of the A and B vocabularies. These words are the same scientific terms in English, but many of them have had their meanings rigidified in order to, just like with the A vocabulary, attempt to prevent speakers from being able to express anti- government thoughts.
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With a suitable choice of the rigidifying data, the modified moduli problem will have a (fine) moduli space T, often described as a subscheme of a suitable Hilbert scheme or Quot scheme. The rigidifying data is moreover chosen so that it corresponds to a principal bundle with an algebraic structure group G. Thus one can move back from the rigidified problem to the original by taking quotient by the action of G, and the problem of constructing the moduli space becomes that of finding a scheme (or more general space) that is (in a suitably strong sense) the quotient T/G of T by the action of G. The last problem, in general, does not admit a solution; however, it is addressed by the groundbreaking geometric invariant theory (GIT), developed by David Mumford in 1965, which shows that under suitable conditions the quotient indeed exists. To see how this might work, consider the problem of parametrizing smooth curves of the genus g > 2. A smooth curve together with a complete linear system of degree d > 2g is equivalent to a closed one dimensional subscheme of the projective space Pd−g.
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