From there the neuron doctrine spread, replacing the prevailing reticular theory.
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The old brain includes the brain stem, medulla, pons, reticular formation, thalamus, cerebellum, amygdala, hypothalamus and hippocampus.
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"Crow's-feet around eyes refer to contractions of their reticular oculi muscles, which are activated when someone smiles," Rule explains.
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In a class on the brain, an instructor mentioned a neural pathway, the reticular activating system, that was associated with wakefulness.
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"Light is the strongest stimulus to the reticular activating system," Dr. Rodrigues told me, referring to the system that regulates your sleepiness/wakefulness.
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Spindles are produced in the thalamic reticular nucleus, which is kind of like a relay station for signals coming from the cerebral cortex.
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An irony of the joint prize (for revealing the structure of the nervous system) is that Golgi remained unconvinced by the Neuron Doctrine and true to reticular theory, which saw neurons as physically connected.
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Reticular connective tissue is a type of connective tissue with a network of reticular fibers, made of type III collagen (reticulum = net or network). Reticular fibers are not unique to reticular connective tissue, but only in this type are they dominant. Reticular fibers are synthesized by special fibroblasts called reticular cells. The fibers are thin branching structures.
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Neurons of the reticular formation, particularly those of the ascending reticular activating system, play a crucial role in maintaining behavioral arousal and consciousness. The overall functions of the reticular formation are modulatory and premotor, involving somatic motor control, cardiovascular control, pain modulation, sleep and consciousness, and habituation. The modulatory functions are primarily found in the rostral sector of the reticular formation and the premotor functions are localized in the neurons in more caudal regions. The reticular formation is divided into three columns: raphe nuclei (median), gigantocellular reticular nuclei (medial zone), and parvocellular reticular nuclei (lateral zone).
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The fibroblasts contain organelles that are necessary for the synthesis and excretion of proteins needed to repair the tissue damage. Fibrocytes usually do not leave the connective tissue. Reticular cells are usually larger than fibrocytes. Reticular cells are the fibrocytes of reticular connective tissue and form a network of reticular fibers.
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The midbrain reticular formation (MRF) also reticular formation of midbrain, mesencephalic reticular formation, tegmental reticular formation, formatio reticularis (tegmenti) mesencephali) is a structure in the midbrain consisting of the dorsal tegmental nucleus, ventral tegmental nucleus, and cuneiform nucleus. These are also known as the tegmental nuclei.NeuroNames. tegmental nuclei. BrainInfo. Accessed January 25, 2011.
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The parvocellular reticular nucleus is part of the brain located dorsolateral to the caudal pontine reticular nucleus. The dorsal portion of the reticular nucleus has been shown to innervate the mesencephalic trigeminal nucleus and its surrounding area. Also, it projects to the facial nucleus, hypoglossal nucleus and parabrachial area along with parts of the caudal parvocellular reticular formation.Ter Horst, GJ et al.
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The oral pontine reticular nucleus, or rostral pontine reticular nucleus, is delineated from the caudal pontine reticular nucleus. This nucleus tapers into the lower mesencephalic reticular formation and contains sporadic giant cells. Different populations of the pontis oralis have displayed discharge patterns which coordinate with phasic movements to and from paradoxical sleep. From this information it has been implied that the n.r.
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The caudal pontine reticular nucleus or nucleus reticularis pontis caudalis is an portion of the reticular formation, composed of gigantocellular neurons. In rabbits and cats it is exclusively giant cells, however in humans there are normally sized cells as well. The caudal pontine reticular nucleus is rostral to the gigantocellular reticular nucleus and is located in the caudal pons. The caudal pontine reticular nucleus has been known to mediate head movement, in concert with the gigantocellular nucleus and the superior colliculus.
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Ascending reticular activating system. Reticular formation labeled near center. The ascending reticular activating system (ARAS), also known as the extrathalamic control modulatory system or simply the reticular activating system (RAS), is a set of connected nuclei in the brains of vertebrates that is responsible for regulating wakefulness and sleep-wake transitions. The ARAS is a part of the reticular formation and is mostly composed of various nuclei in the thalamus and a number of dopaminergic, noradrenergic, serotonergic, histaminergic, cholinergic, and glutamatergic brain nuclei.
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There are more than 20 types of reticular fibers. In Reticular Connective Tissue type III collagen/reticular fiber (100-150 nm in diameter) is the major fiber component. It forms the architectural framework of liver, adipose tissue, bone marrow, spleen and basement membrane, to name a few.
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The dorsal and ventral tegmental nuclei receive connections from the mammillo-tegmental bundle of Gudden, a branch of the mammillothalamic tract. The bundle of Gudden might be identical to the hypothalamotegmental tract. Along with the oral pontine reticular nucleus, the midbrain reticular formation projects to the gigantocellular reticular nucleus. The midbrain reticular formation is the point at which the different algedonic signals come together, ensuring that the organism is aware of potential threats.
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A liver biopsy stained with a reticulin stain demonstrating a normal hepatic plate thickness and mild steatosis. Reticular fibers, reticular fibres or reticulin is a type of fiber in connective tissue composed of type III collagen secreted by reticular cells. Reticular fibers crosslink to form a fine meshwork (reticulin). This network acts as a supporting mesh in soft tissues such as liver, bone marrow, and the tissues and organs of the lymphatic system.
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The ventral reticular nucleus is a continuation of the parvocellular nucleus in the brainstem. The ventral reticular nucleus has been shown to receive afferent projections from the dentate gyrus in rabbits.Tang, ZW et al. The fiber projections from the dentate nucleus to the reticular formation of the brain stem in the rabbit.
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Anatomy and Embryology (Berlin). 1987;175(4):517-20. The rostral portion of the ventral reticular nucleus has been shown to mediate inspiration along with a portion of the lateral reticular nucleus.
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In human neuroanatomy, the hypothalamotegmental tract is a pathway from the hypothalamus to the reticular formation. Axons from the posterior hypothalamus descend through the mesencephalic and pontine reticular formations. They connect with reticular neurons important in visceral and autonomic activity. The tract is a continuation of the medial forebrain bundle in the lateral portion of the tegmentum.
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Medium sized moths. Male and female antennae cup-shaped; forewing elongate with slight reticular pattern, often with a spot in the costal area and spots in the postdiscal area; hindwing with indistinct reticular pattern.
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Thalamic Reticular Nucleus is variously abbreviated TRN, RTN, NRT, and RT.
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The medial pontine reticular formation (MPRF) is a part of the human brain located in the pons of the brainstem (specifically the central pontine reticular formation). It plays a critical function in the generation of REM sleep.
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The reticular formation is a set of interconnected nuclei that are located throughout the brainstem. It is not anatomically well defined, because it includes neurons located in different parts of the brain. The neurons of the reticular formation make up a complex set of networks in the core of the brainstem that extend from the upper part of the midbrain to the lower part of the medulla oblongata. The reticular formation includes ascending pathways to the cortex in the ascending reticular activating system (ARAS) and descending pathways to the spinal cord via the reticulospinal tracts.
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The reticular dermis is the lower layer of the dermis, found under the papillary dermis, composed of dense irregular connective tissue featuring densely packed collagen fibers. It is the primary location of dermal elastic fibers. The reticular region is usually much thicker than the overlying papillary dermis. It receives its name from the dense concentration of collagenous, elastic, and reticular fibers that weave throughout it.
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The thalamic reticular nucleus receives input from the cerebral cortex and dorsal thalamic nuclei. Most input comes from collaterals of fibers passing through the thalamic reticular nucleus. Primary thalamic reticular nucleus efferent fibers project to dorsal thalamic nuclei, but never to the cerebral cortex. This is the only thalamic nucleus that does not project to the cerebral cortex, instead it modulates the information from other nuclei in the thalamus.
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The 1953 Science article mentioned above concluded that the reticular and regular collagenous materials contains the same four sugars – galactose, glucose, mannose, and fucose – but in a much greater concentration in the reticular than in the collagenous material. In a 1993 paper, the reticular fibers of the capillary sheath and splenic cord were studied and compared in the pig spleen by transmission electron microscopy. This paper attempted to reveal their components and the presence of sialic acid in the amorphous ground substance. Collagen fibrils, elastic fibers, microfibrils, nerve fibers, and smooth muscle cells were observed in the reticular fibers of the splenic cord.
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Retrograde studies have shown that the deep mesencephalic reticular formation and oral pontine reticular nucleus project to the gigantocellular nucleus. The dorsal rostral section of the nucleus reticularis gigantocellularis is also involved in mediating expiration (or out-breathing) along with the parvocellular nucleus.
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A reticular cell is a type of fibroblast that synthesizes collagen alpha-1(III) and uses it to produce reticular fibers. The cell surrounds the fibers with its cytoplasm, isolating it from other tissue components and cells. Reticular cells provide structural support, since they produce and maintain the thin networks of fibres that are a framework for most lymphoid organs. They are found in many tissues including the spleen, lymph nodes and lymph nodules.
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The reticular region lies deep in the papillary region and is usually much thicker. It is composed of dense irregular connective tissue, and receives its name from the dense concentration of collagenous, elastic, and reticular fibres that weave throughout it. These protein fibres give the dermis its properties of strength, extensibility, and elasticity. Also located within the reticular region are the roots of the hairs, sebaceous glands, sweat glands, receptors, nails, and blood vessels.
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Eysenck's three-factor model of personality was a causal theory of personality based on activation of reticular formation and limbic system. The reticular formation is a region in the brainstem that is involved in mediating arousal and consciousness. The limbic system is involved in mediating emotion, behavior, motivation, and long-term memory. #Extraversion (E) – degree to which people are outgoing and are interactive with people, which is mediated by the activation of the reticular formation.
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Noradrenergic cell group A1 is a group of cells in the vicinity of the lateral reticular nucleus of the medullary reticular formation that label for norepinephrine in primates and rodents. They are found in the ventrolateral medulla in conjunction with the adrenergic cell group C1.
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The other four nuclei (the external cuneate nucleus, the lateral reticular nucleus, the pontine nucleus, and the thalamic reticular nucleus) project mossy fibers to innervate granule neurons. Meanwhile, cells in the ventricular zone evolve into GABAergic Purkinje cells (another type of cerebellar neuron) and deep cerebellar nuclei.
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Running across it are a number of finer trabeculae of reticular fibers, mostly covered by ramifying cells.
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On the other hand, only microfibrils were recognized in the reticular fibers of the capillary sheath. The binding of LFA lectin to the splenic cord was stronger than the capillary sheath. These findings suggested that the reticular fibers of the splenic cord include multiple functional elements and might perform an important role during contraction or dilation of the spleen. On the other hand, the reticular fiber of the capillary sheath resembled the basement membrane of the capillary in its components.
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Its function is modulatory on signals going through thalamus (and the reticular nucleus). The thalamic reticular nucleus receives massive projections from the external segment of the Globus Pallidus, thought to play a part in disinhibition of thalamic cells, which is essential for initiation of movement (Parent and Hazrati, 1995) It has been suggested that the reticular nucleus receives afferent input from the reticular formation and in turn projects to the other thalamic nuclei, regulating the flow of information through these to the cortex. There is debate over the presence of distinct sectors within the nucleus that each correspond to a different sensory or cognitive modality. For original connectivity anatomy see Jones 1975.
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The forewings are white, with a small grey reticular pattern. There is a costal row of dark dots and greyish brown transverse striae on the dorsum. The hindwings have a similar reticular pattern and a white anal area., 2011: Two new species of the goat moths (Lepidoptera, Cossidae) from New Guinea.
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A good example of this is a person who can sleep through loud traffic in a large city, but is awakened promptly due to the sound of an alarm or crying baby. Reticular formation nuclei that modulate activity of the cerebral cortex are part of the ascending reticular activating system.
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In the cat the superior colliculus projects through the reticular formation and interacts with motor neurons in the brainstem.
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Therefore, MRN is a functional antagonist of the reticular formation which plays a critical role in hippocampal theta generation.
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The medulla contains plasma cells, as well as macrophages which are present within the medullary sinuses. As part of the reticular network, there are follicular dendritic cells in the B cell follicle and fibroblastic reticular cells in the T cell cortex. The reticular network provides structural support and a surface for adhesion of the dendritic cells, macrophages and lymphocytes. It also allows exchange of material with blood through the high endothelial venules and provides the growth and regulatory factors necessary for activation and maturation of immune cells.
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The paramedian nucleus receives afferents mostly from the fastigial nucleus in the cerebellum and the cerebral cortex; however, the projections from the spinal cord are very sparse. The descending afferent connections come mostly from the frontal and parietal lobes; however the pontine reticular formation also sends projections to the paramedian reticular nucleus. There are also very sparse innervations from the superior colliculus. Lesions in the paramedian reticular nucleus have been shown to cause a stereotyped increase in the random patterns of motion in rats.
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The condition's name derives from the Latin livere which means bluish, and reticular which refers to the net-like pattern.
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The macrophages are usually located on the edge of the milky spot and the lymphocytes in the middle. Other structural elements are plasmocytes and various connective tissue cells including reticular and elastic fibres. There is seen to be a delicate framework of reticular fibres supporting the structure. Blood supply is from the gastroepiploic arteries.
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Hall pp51 These cochlear supporting cells include a somatic part, with its cupula, and a phalangeal process, which links the Deiters soma to the reticular lamina. The part of the phalanx which is included in the reticular lamina is the apex of the phalanx (phalangeal apex). The cells are named for neuroanatomist Otto Deiters.
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The term "reticular formation" was coined in the late 19th century by Otto Deiters, coinciding with Ramon y Cajal’s neuron doctrine. Allan Hobson states in his book The Reticular Formation Revisited that the name is an etymological vestige from the fallen era of the aggregate field theory in the neural sciences. The term "reticulum" means "netlike structure", which is what the reticular formation resembles at first glance. It has been described as being either too complex to study or an undifferentiated part of the brain with no organization at all.
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There are three types of fibers commonly found within the stroma: collagen type I, elastic, and reticular (collagen type III) fibres.
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These protein fibers give the dermis its properties of strength, extensibility, and elasticity. Within the reticular region are the roots of the hair, sebaceous glands, sweat glands, receptors, nails, and blood vessels. The orientation of collagen fibers within the reticular dermis creates lines of tension called Langer's lines, which are of some relevance in surgery and wound healing.
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The reticulotegmental nucleus also receives efferent axons from the cerebellum. This nucleus is known for its large number of multipolar cells and its particularly reticular structure. The reticulotegmental nucleus is topographically related to pontine nuclei (non-reticular), being just dorsal to them. The reticulotegmental nucleus has been known to mediate eye movements, otherwise known as saccadic movement.
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Planning needed a structure to allow natural and meaningful input from citizens.[Smith, R. W. A theoretical basis for participatory planning. Policy Sci 4, 275–295 (1973)] In order for this to happen, planning needed to move away from its hierarchical model and move toward a reticular model. The reticular model would allow for more citizen participation.
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There, it terminates in the tegmentum of the midbrain at the dorsal and ventral tegmental nuclei and the tegmental pontine reticular nucleus.
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The medial reticular formation and lateral reticular formation are two columns of nuclei with ill-defined boundaries that send projections through the medulla and into the midbrain. The nuclei can be differentiated by function, cell type, and projections of efferent or afferent nerves. Moving caudally from the rostral midbrain, at the site of the rostral pons and the midbrain, the medial RF becomes less prominent, and the lateral RF becomes more prominent. Existing on the sides of the medial reticular formation is its lateral cousin, which is particularly pronounced in the rostral medulla and caudal pons.
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Anchoring fibrils (composed largely of type VII collagen) extend from the basal lamina of epithelial cells and attach to the lamina reticularis (also known as the reticular lamina) by wrapping around the reticular fiber (collagen III) bundles. The basal lamina and lamina reticularis together make up the basement membrane. Anchoring fibrils are essential to the functional integrity of the dermoepidermal junction.
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The gigantocellular reticular nucleus (Gi) is a subregion of the medullary reticular formation. As the name indicates, it consists mainly of so-called giant neuronal cells. This nucleus has been known to innervate the caudal hypoglossal nucleus, and responds to glutamatergic stimuli. The gigantocellular nucleus excites the hypoglossal nucleus, and can play a role in the actions of the said nerve.
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The thalamic reticular nucleus is part of the ventral thalamus that forms a capsule around the thalamus laterally. However, recent evidence from mice and fish question this statement and define it as a dorsal thalamic structure. It is separated from the thalamus by the external medullary lamina. Reticular cells are GABAergic, and have discoid dendritic arbors in the plane of the nucleus.
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Fibroblastic reticular cells (FRCs) are located in the T cell zone of the cortex. FRCs produce collagen alpha-1(III) rich reticular fibers that form a dense network within the lymphoid tissue. These are connected by collagen XIV, small leucine-rich proteoglycans and lysyl oxidase. The network of fibers supports and guides the movement of dendritic cells (DCs), T lymphocytes and B lymphocytes.
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The paradigm shift from radial-orbital to Reticular-Matrix means changing the metropolitan game from darts (aiming for the center) to chess (diverse location strategies).
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The most common types of myoclonus include action, cortical reflex, essential, palatal, those seen in the progressive myoclonus epilepsies, reticular reflex, sleep and stimulus-sensitive.
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Tooth plates of R. tuberculatus are characterised by four transverse ridges, broadly rounded crests, a reticular pattern of ridges and hollows, and large adult size.
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The midbrain tegmentum is the part of the midbrain extending from the substantia nigra to the cerebral aqueduct in a horizontal section of the midbrain. Structures included in the midbrain tegmentum include the red nucleus, reticular formation, and substantia nigra. The red nucleus is responsible for controlling basic body and limb movements. The reticular formation controls arousal and self-consciousness, and the [substantia nigra] integrates voluntary movements.
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Marginal reticular cells (MRCs) form a layer of cells beneath the subcapsular sinuses. Via the reticular network, the MRCs bring antigens from the sub- capsular sinuses to the B cell follicles. MRCs express the molecule TRANCE (also known as RANKL), a type of tumor necrosis factor. They are one of organizer cells involved in the formation of the structure of lymph node during organogenesis.
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The reticular formation consists of more than 100 small neural networks, with varied functions including the following: # Somatic motor control – Some motor neurons send their axons to the reticular formation nuclei, giving rise to the reticulospinal tracts of the spinal cord. These tracts function in maintaining tone, balance, and posture—especially during body movements. The reticular formation also relays eye and ear signals to the cerebellum so that the cerebellum can integrate visual, auditory, and vestibular stimuli in motor coordination. Other motor nuclei include gaze centers, which enable the eyes to track and fixate objects, and central pattern generators, which produce rhythmic signals of breathing and swallowing.
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They are short, fine lines throughout the lungs, with a reticular appearance. They may represent thickening of anastomotic lymphatics or superimposition of many Kerley B lines.
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Eggshells possibly belonging to Eolambia have been discovered at various localities alongside isolated teeth. They have reticular (net-like) surface patterns, and have a thickness of .
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Ascending reticular activation in cats can produce mydriasis, which can result from prolonged pain. These results suggest some relationship between ARAS circuits and physiological pain pathways.
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The paramedian reticular nucleus (in Terminologia Anatomica, or paramedian medullary reticular group in NeuroNames) sends its connections to the spinal cord in a mostly ipsilateral manner, although there is some decussation. It projects to the vermis in the anterior lobe, the pyramis and the uvula. The paramedian nucleus also projects to the contralateral PRN, the gigantocellular nucleus, and the nucleus ambiguous.Jouvet, M. Handbook of clinical neurology vol 3.
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The pedunculopontine nucleus is a part of the reticular formation in the brainstemMesulam et al. 1989 and a main component of the reticular activating system, and gives a major input to the basal ganglia. As indicated by its name, it is located at the junction between the pons and the cerebral peduncle, and near the substantia nigra. The axons are either excitatory or inhibitory and mainly target the substantia nigra.
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It is different from retrosynthesis of organic compounds, because the structural integrity and rigidity of the building blocks in reticular synthesis remain unaltered throughout the construction process—an important aspect that could help to fully realize the benefits of design in crystalline solid-state frameworks. Similarly, reticular synthesis should be distinguished from supramolecular assembly, because in the former, building blocks are linked by strong bonds throughout the crystal.
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Acta Veterinaria Scandinavica 53:19] The reticulum is adjacent to the diaphragm, lungs, abomasum, rumen and liver. The heights of the reticular crests and depth of the structures vary across ruminant animal species.[Clauss, M., Hofmann, R. R., Streich, W. J., Fickel, J., and Hummel, J. 2009. Convergence in the macroscopic anatomy of the reticulum in wild ruminant species of different feeding types and a new resulting hypothesis on reticular function.
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Thalamocortical networks consist of neurons in both the thalamus and cortex. The thalamic neurons are typically one of three types: thalamocortical, with axons extending into the cortex, reticular, and thalamic interneurons. Thalamocortical neurons (TC) vary significantly in size, which is correlated with the depth to which they project into the cortex. These cells are limited in their outputs and seem to only connect to the cortical layers and reticular thalamic neurons.
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Fibroblasts make collagen fibres, glycosaminoglycans, reticular and elastic fibers. Growing individuals' fibroblasts are dividing and are synthesizing ground substance. Tissue damage stimulates fibrocytes and induces the production of fibroblasts.
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The fibers form a soft skeleton (stroma) to support the lymphoid organs (lymph node stromal cells, red bone marrow, and spleen). Adipose tissue is held together by reticular fibers.
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It sends nerve fibres to the subthalamic nucleus and putamen. It receives nerve fibres from the cerebral cortex, vestibular nuclei, globus pallidus, superior colliculus, reticular formation, and spinothalamic tract.
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Along with the vestibular membrane, several tissues held by the basilar membrane segregate the fluids of the endolymph and perilymph, such as the inner and outer sulcus cells (shown in yellow) and the reticular lamina of the organ of Corti (shown in magenta). For the organ of Corti, the basilar membrane is permeable to perilymph. Here the border between endolymph and perilymph occurs at the reticular lamina, the endolymph side of the organ of Corti.
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The reticular theory predominated until the 1890s when Ramon y Cajal brought forth his neuron doctrine of synaptic junctions, which in essence replaced the reticular theory. Gerlach was one of the first physicians to use photomicrography for medical research. In 1863 he published a handbook titled Die Photographie als Hilfsmittel mikroskopischer Forschung (Engl. "Photography as a tool in microscopic science") in which he discusses the practical and technological aspects of microscopic photography.
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Reticular neurons send signals to the thalamus, which in turn sends activity- level-controlling signals to every part of the cortex. Damage to the reticular formation can produce a permanent state of coma. Sleep involves great changes in brain activity. Until the 1950s it was generally believed that the brain essentially shuts off during sleep, but this is now known to be far from true; activity continues, but patterns become very different.
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Cell group B8 is located in the dorsal part of the median raphe nucleus (superior central nucleus) and adjacent structures of the pontine reticular formation of the rodent and the primate.
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Ocular flutter is an opsoclonic disorder that results in horizontal saccades. It is caused by damage to the brainstem paramedian pontine reticular formation cells or the cerebellar neurons controlling those cells.
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The ascending reticular activating system is an important enabling factor for the state of consciousness. The ascending system is seen to contribute to wakefulness as characterised by cortical and behavioural arousal.
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Foltz’ initial research concerned "coma of head injury." He studied monkeys with electrodes implanted in the reticular system and also cortical electrodes. He used evoked responses to demonstrate a selective depression of electrical activity in the reticular formation by the cerebral concussion, with minimal effect on primary ascending sensory pathways. The effect was reversed (in part) by atropine therapy. "Psychosomatic disease states in monkeys and the limbic system" was the result of Foltz’ investigation of chaired "executive" monkeys.
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The RAS, on the other hand, is a more primitive structure in the brainstem which includes the reticular formation (RF). The RAS has two tracts, the ascending and descending tract. The ascending track, or ascending reticular activating system (ARAS), is made up of a system of acetylcholine-producing neurons, and works to arouse and wake up the brain. Arousal of the brain begins from the RF, through the thalamus, and then finally to the cerebral cortex.
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The reticulotegmental nucleus, tegmental pontine reticular nucleus (or pontine reticular nucleus of the tegmentum) is an area within the floor of the midbrain. This area is known to affect the cerebellum with its axonal projections. These afferent connections have been proven to project not only ipsilaterally, but also to decussate and project to the contralateral side of the vermis. It has also been shown that the projections from the pontine tegmentum to the cerebellar lobes are only crossed fibers.
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Eric Kandel describes the reticular formation as being organized in a similar manner to the intermediate gray matter of the spinal cord. This chaotic, loose, and intricate form of organization is what has turned off many researchers from looking farther into this particular area of the brain. The cells lack clear ganglionic boundaries, but do have clear functional organization and distinct cell types. The term "reticular formation" is seldom used anymore except to speak in generalities.
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Furthermore, single-shock stimulation of the sciatic nerve also activated the medial reticular formation, hypothalamus, and thalamus. Excitation of the ARAS did not depend on further signal propagation through the cerebellar circuits, as the same results were obtained following decerebellation and decortication. The researchers proposed that a column of cells surrounding the midbrain reticular formation received input from all the ascending tracts of the brain stem and relayed these afferents to the cortex and therefore regulated wakefulness.
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The gene product is found primarily in the perinuclear region, the sarcolemmal membrane, and in the reticular pattern of the sarcoplasm. However, localization assays predict it to also be found in the cytoplasm.
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The ryanodine-inositol 1,4,5-triphosphate receptor Ca2+ channel (RIR-CaC) family includes Ryanodine receptors and Inositol trisphosphate receptors. Members of this family are large proteins, some exceeding 5000 amino acyl residues in length. This family belongs to the Voltage-gated ion channel (VIC) superfamily. Ry receptors occur primarily in muscle cell sarcoplasmic reticular (SR) membranes, and IP3 receptors occur primarily in brain cell endoplasmic reticular (ER) membranes where they effect release of Ca2+ into the cytoplasm upon activation (opening) of the channel.
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Schematic Figure of Reticular Chemistry. The term ‘secondary building unit’ has been used for some time to describe conceptual fragments which can be compared as bricks used to build a house of zeolites; in the context of this page it refers to the geometry of the units defined by the points of extension.Yaghi, O. M.; O'Keeffe, M.; Ockwig, N. W.; Chae, H. K.; Eddaoudi, M.; Kim, J.; Reticular synthesis and the design of new materials. Nature. 2003, 423, pp 705-714.
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The model of a reticular network of directly interconnected cells was one of the early hypotheses for the organization of the nervous system at the beginning of the 20th century. This reticular hypothesis was considered to conflict directly with the now predominant neuron doctrine, a model in which isolated, individual neurons signal to each other chemically across synaptic gaps. These two models came into sharp contrast at the award ceremony for the 1906 Nobel Prize in Physiology or Medicine, in which the award went jointly to Camillo Golgi, a reticularist and widely recognized cell biologist, and Santiago Ramón y Cajal, the champion of the neuron doctrine and the father of modern neuroscience. Golgi delivered his Nobel lecture first, in part detailing evidence for a reticular model of the nervous system.
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Reticular erythematous mucinosis (REM) is a skin condition caused by fibroblasts producing abnormally large amounts of mucopolysaccharides. It is a disease that tends to affect women in the third and fourth decades of life.
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Reticular connective tissue is found around the kidney, liver, the spleen, and lymph nodes, Peyer's patches as well as in bone marrow.Martini, Frederic H. Fundamentals of Anatomy and Physiology. Seventh Edition. Pearson Benjamin Cummings.
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The hypoglossal nucleus interacts with the reticular formation, involved in the control of several reflexive or automatic motions, and several corticonuclear originating fibers supply innervation aiding in unconscious movements relating to speech and articulation.
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It has been shown in cats that electrical stimulation of the reticular formation can make a standing cat lie down. Also, stimulation of the cat in an alternative spot can make a lying cat stand.
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PLoS ONE 7(4): e33479. . This species is part of a complex that comprises Felimida binza (Ev. Marcus & Er. Marcus, 1963). These species share a similar reticular pattern of yellow and red pigment and morphology.
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Mitochondria routinely undergo fission and fusion events that maintain a dynamic reticular network. Drp1 is a fundamental component of mitochondrial fission. Indeed, Drp1 deficient neurons have large, strongly interconnected mitochondria., due to dysfunctional fission machinery.
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In eukaryotes, they are present in the plasma membranes or endoplasmic reticular membranes. In prokaryotes, they are localized to the cytoplasmic membranes. P-type ATPases from 26 eukaryotic species were analyzed later. Chan et al.
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Medium sized moths. Male antennae cup-shaped, those of female bipectinate (apically with gradually reducing pectin); forewing long, with rounded apex, with dense reticular pattern formed by transverse lines and spots; hindwing lightly coloured and uniform.
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Reticular formation (includes Raphe nuclei responsible for serotonin production) is signaled to release serotonin during and after a meal to suppress appetite.Hornung, Jean-Pierre. "The Human Raphe Nuclei and the Serotonergic System."Science Direct. Dec. 2003. Web.
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The sparsely to moderately villous pods have a length of around and a width of and have obscure nerves that are arranged in a reticular manner. The seeds inside are arranged transversely and are about in length.
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Lymph node stromal cells can give rise to a number of malignancies including: follicular dendritic cell sarcoma; fibroblastic reticular cell sarcoma; inflammatory myofibroblastic tumours and others.Jones D. "Neoplastic Hematopathology: Experimental and Clinical Approaches." Springer, 2010 p461. , 9781607613848.
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Once at Northwestern, Moruzzi met Horace Winchell Magoun and Donald B. Lindsley, and they worked to elucidate the neural processes responsible for wakefulness. Until the 1940s, some scientists felt like wakefulness simply required an adequate level of sensory input rather than a specific process inside the brain. In a 1949 experiment with a cat, Moruzzi and Magoun proved that stimulation of a certain brain region (near the intersection of the pons and midbrain) created a state of alertness. This stimulated area of the brain became known as the reticular activating system or reticular formation.
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A lengthening of prestin lengthens the hair cell while prestin contraction leads to a decrease in OHC length. Because the OHC is tightly associated with the reticular lamina and the Deiter's cell, shape change of the OHC leads to movement of these upper and lower membranes, causing changes in vibrations detected in the cochlear partition. Upon initial deflection of the BM causing positive hair bundle deflection, the reticular lamina is pushed downward, resulting in a negative deflection of the hair bundles. This causes stereocilia channel closing which leads to hyperpolarization and OHC elongation.
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McCulloch also posited the concept of "poker chip" reticular formations as to how the brain deals with contradictory information in a democratic, somatotopical neural network. His principle of "Redundancy of Potential Command"Some Mechanisms For A Theory of the Reticular Formation was developed by von Foerster and Pask in their study of self-organization"A Predictive Model for Self-Organizing Systems", Part I: Cybernetica 3, pp. 258–300; Part II: Cybernetica 4, pp. 20–55, 1961 Heinz von Foerster and Gordon Pask and by Pask in his Conversation Theory and Interactions of Actors Theory.
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Epithelial reticular cells are the primary cell involved with making sure that no T cells are allowed to survive which could attack the body's own cells. It does this by expressing a very large proportion of its genome, and expressing as many 'self' proteins on its cell membrane as possible. As the T cells migrate from the cortex of the thymus to the medulla, they come into contact with many epithelial reticular cells, and if they recognise self proteins as a pathogen, then the epithelial cells destroy them.
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In this study, relay and reticular thalamic neurons of epileptic and non-epileptic rats were dual extracellularly recorded and juxtacellularly labeled. Medium oscillations (5–9 Hz) in both types of rats were noted to occur randomly in an unsynchronized pattern in relay and reticular neurons. However, spontaneous spike-and-wave discharges were observed in epileptic rats when the medium oscillations became synchronized, suggesting a dependence of the two. However, since medium ranged oscillations only developed into spike-and-wave discharges spontaneously, genetic factors also seem to contribute to the initiation of synchronized oscillations.
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The reticular membrane (RM, also called reticular lamina or apical cuticular plate)Histology and Virtual Microscopy Learning Resources University of Michigan Medical School; accessed 4 Apr 2013 is a thin, stiff lamina that extends from the outer hair cells to the Hensen's cells.Radivoj V. Krstic. Human Microscopic Anatomy: An Atlas for Students of Medicine and Biology Springer, 1991; pp 554. . The RM is composed of "minute-fiddle-shaped cuticular structures" called the phalangeal extensions of the outer hair cells, interspaced with extensions coming from the outer phalangeal cells.
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In response to audio stimuli, the mind's way of interpreting sound can be translated through a regulatory process called The Reticular Activating System. Located in the brain stem, The Reticular Activating System continually listens, even throughout delta-wave sleep, to determine importance of sounds in relation to waking the cortex or the rest of the body from sleep. Chalkboard scraping, or noises that elicit an emotional response have been known to trigger tendencies from the fight or flight response which acts as the body's primary self-defense mechanism.
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P. J. Vinken and G. W. Bruyen, eds. North Holland Publishing company. Amsterdam (1969). The paramedian reticular formation is adjacent to the abducens (VI)nucleus in the pons and adjacent to the oculomotor nucleus(III) in the midbrain.
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Deposits of versican are not present in normal skin but are found in the reticular dermis during keloid scarring, a condition where scar formation becomes uncontrolled and overgrowth of skin tissue occurs at the site of the wound.
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Yaghi pioneered reticular chemistry, a new field of chemistry concerned with stitching molecular building blocks together by strong bonds to make open frameworks." Omar Yaghi wins Albert Einstein World Award of Science ", Chemical & Engineering News, 10 July 2017.
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There is a small, horn-like tubercle at the edge of the eyelid. Ventral surface is smooth. Colouration above is red brown or olive brown, with the dorsum bearing a dark, reticular marking. Males have a single vocal sac.
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The descending rubrospinal tract and reticulospinal tract originate in the red nucleus and reticular formation (which is closely associated with the central tegmental tract) respectively, thereby providing the mechanism by which this circuit exerts its effects on spinal cord motor activity.
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For terms see gastropod shell. Shell The shell is amber reddish in colour, rarely whitish. It is milky white near the umbilicus. The shell is finely striated with spiral lines producing a fine reticular pattern (less prominent than in A. pura).
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Selenite crystals that exhibit in either reticular or acicular habits, satin spar, in general (as fibrous crystals are thin and narrow), desert roses that are thinly bladed, and gypsum flowers, particularly acicular gypsum flowers, can be quite brittle and easily broken.
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Some of the "pain fibers" in the ALS deviate from their pathway towards the VPLN. In one such deviation, axons travel towards the reticular formation in the midbrain. The reticular formation then projects to a number of places including the hippocampus (to create memories about the pain), the centromedian nucleus (to cause diffuse, non-specific pain) and various parts of the cortex. Additionally, some ALS axons project to the periaqueductal gray in the pons, and the axons forming the periaqueductal gray then project to the nucleus raphes magnus, which projects back down to where the pain signal is coming from and inhibits it.
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Von Economo, in his studies, noticed that lesions in the connection between the midbrain and the diencephalon caused prolonged sleepiness and therefore proposed the idea of an ascending arousal system. During the past few decades major ascending pathways have been discovered with located neurons and respective neurotransmitters. This pathway divides into two branches: one that ascends to the thalamus and activates the thalamus relay neurons, and another one that activates neurons in the lateral part of the hypothalamus and the basal forebrain, and throughout the cerebral cortex. This refers to the ascending reticular activating system (cf reticular formation).
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Perihypoglossal nuclei (nuclei perihypoglossales), called also perihypoglossal complex or perihypoglossal nuclear complex or satellite nuclei is a group of neurons in the floor of the fourth ventricle, in close proximity to the nucleus of the hypoglossal nerve in the gray substance of the medulla oblongata, all of which contain cells with characteristics suggestive of reticular connections. The complex includes three nuclei: the intercalated nucleus, the nucleus prepositus, and the sublingual nucleus. The nucleus prepositus is the largest of the three. Perihypoglossal nuclei receive afferents from the cerebral cortex, vestibular nuclei, accessory oculomotor nuclei, and paramedian pontine reticular formation.
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In contrast, reticular reflex myoclonus occurs spontaneously to stimuli applied to distal limbs. Spinal myoclonus is caused by defects in spinal organization or connections, and peripheral myoclonus has symptoms of rhythmic jerks due to a neuron-the most common being the hemifacial spasm.
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Projections from the rostral parvocellular reticular formation to pontine and medullary nuclei in the rat: involvement in autonomic regulation and orofacial motor control. Neuroscience. 1991;40(3):735-58. This nucleus is also involved in expiration with a part of the gigantocellular nucleus.
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Vertebrate hematopoietic stem cells niche in the bone marrow is formed by cells subendosteal osteoblasts, sinusoidal endothelial cells and bone marrow stromal (also sometimes called reticular) cells which includes a mix of fibroblastoid, monocytic and adipocytic cells (which comprise marrow adipose tissue).
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Touch-position information is handled differently. Diffuse thalamic projections from the IL and other thalamic nuclei are responsible for a given level of consciousness, with the thalamus and reticular formation "activating" the brain; peripheral pain-temperature information also feeds directly into this system.
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In their experiments, Moruzzi and Magoun also transected the cat's reticular formation without disrupting any of the sensory nerves; the cat was rendered comatose. The experiment shifted science's conception of sleep from a passive process to one that was actively controlled by the brain.
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The disease has started to invade the neocortex and spreads into the structures of the temporal, parietal, and frontal lobes. Cell death can be observed in the substantia nigra, the dorsal motor nucleus of the vagus nerve, the gigantocellular reticular nucleus, and the locus ceruleus.
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Metropolitan Reticular Matrix Planning detected that, counter to Walter Christaller’s Central Place Theory, metropolises and urban systems do not exist in ‘featureless plains’. This notion is the precondition to the application of Christaller's theory.Christaller, Walter (1933): Die zentralen Orte in Süddeutschland. Gustav Fischer, Jena.
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Infection may remain as the latent form for a long time, and when the function of reticular endothelial cells is deteriorated, it may become activated and consequently, it may secondarily induce spreading infection in the bone several months or several years after acute salmonellosis.
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A large portion of the brainstem is involved in such autonomic control of the body. Such functions may engage the heart, blood vessels, and pupils, among others. The brainstem also holds the reticular formation, a group of nuclei involved in both arousal and alertness.
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The Lombard effect depends upon audio-vocal neurons in the periolivary region of the superior olivary complex and the adjacent pontine reticular formation. It has been suggested that the Lombard effect might also involve the higher cortical areas that control these lower brainstem areas.
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Mass lesions in the brain stem normally cause coma due to their effects on the reticular formation. Mass lesions that occur above the tentorium cerebelli (pictured) normally do not significantly alter the level of consciousness unless they are very large or affect both cerebral hemispheres.
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The ARAS also helps mediate transitions from relaxed wakefulness to periods of high attention. There is increased regional blood flow (presumably indicating an increased measure of neuronal activity) in the midbrain reticular formation (MRF) and thalamic intralaminar nuclei during tasks requiring increased alertness and attention.
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Lymph node tissue showing trabeculae Thin reticular fibers (reticulin) of reticular connective tissue form a supporting meshwork inside the node. The lymph node capsule is composed of dense irregular connective tissue with some plain collagenous fibers, and a number of membranous processes or trabeculae extend from its internal surface. The trabeculae pass inward, radiating toward the center of the node, for about one-third or one-fourth of the space between the circumference and the center of the node. In some animals they are sufficiently well-marked to divide the peripheral or cortical portion of the node into a number of compartments (nodules), but in humans this arrangement is not obvious.
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This raises ethical problems which seem not to have been addressed. It has been argued that sound scientific support is lacking for the claim that the specified purely bedside tests have the power to diagnose true and total death of the brainstem, the necessary condition for the assumption of permanent loss of the intrinsically untestable consciousness-arousal function of those elements of the reticular formation which lie within the brainstem (there are elements also within the higher brain). Knowledge of this arousal system is based upon the findings from animal experimentsWard AA. The relationship between the bulbar-reticular suppressor region and the EEG. Clin Neurophysiol 1949;1:120Lindsley DB et al.
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Obscurin belongs to the family of giant sarcomeric signaling proteins that includes titin and nebulin, and may have a role in the organization of myofibrils during assembly and may mediate interactions between the sarcoplasmic reticulum and myofibrils. Obscurin is the major cytoplasmic ligand for small ankyrin 1 (sANK1), a sarcoplasmic reticular protein, and the scaffolding function of obscurin appears to prevent degradation of sANK1. These data indicate that obscurin serves as a signaling link between the sarcomeric and sarcoplasmic reticular domains, Obscurin plays a role in the formation of new sarcomeres during myofibril assembly. specifically, at the sarcomeric periphery where sites of initiation and progression of myofibrilogenesis lie.
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Reticular theory is an obsolete scientific theory in neurobiology that stated that everything in the nervous system, such as brain, is a single continuous network. The concept was postulated by a German anatomist Joseph von Gerlach in 1871, and was most popularised by the Nobel laureate Italian physician Camillo Golgi. However, the theory was refuted by later observations of a Spanish pathologist Santiago Ramón y Cajal, using a staining technique discovered by Golgi, which showed that nervous tissue, like other tissues, is made of discrete cells. This neuron doctrine turned out to be the correct description of the nervous system, whereas the reticular theory was discredited.
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Although the neural science behind alertness, wakefulness, and arousal are not fully known, the reticular formation is known to play a role in these. The ascending reticular activating system is a postulated group of neural connections that receives sensory input and projects to the cerebral cortex through the midbrain and thalamus from the retucular formation. Since this system is thought to modulate wakefulness and sleep, interference with it, such as injury, illness, or metabolic disturbances, could alter the level of consciousness. Normally, stupor and coma are produced by interference with the brain stem, such as can be caused by a lesion or indirect effects, such as brain herniation.
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The nucleus raphe pallidus receives afferent connections from the periaqueductal gray, the Paraventricular nucleus of hypothalamus, central nucleus of the amygdala, lateral hypothalamic area, and parvocellular reticular nucleus. Also, the nucleus raphe pallidus receives afferents from the medial preoptic area, median preoptic nucleus and lateral paragigantocellular reticular nuclei.Hermann, Dirk M. et al. Afferent projections to the rat nuclei raphe magnus, raphe pallidus and reticularis gigantocellularis pars demonstrated by iontophoretic application of choleratoxin (subunit b). Journal of Chemical Neuroanatomy Volume 13, Issue 1, June 1997, Pages 1-21 The nucleus raphe pallidus has recently been shown to be involved in the activation of a fever as an immunoreaction.
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Kv3.1 and Kv3.2 channels are prominently expressed in neurons that fire at high frequency. Kv3.1 channels are prominently expressed in brain (cerebellum > globus pallidus, subthalamic nucleus, substantia nigra > reticular thalamic nuclei, cortical and hippocampal interneurons > inferior colliculi, cochlear and vestibular nuclei), and in retinal ganglion cells.
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However, the fibers to the abducens (VI) nucleus do not terminate directly onto the nucleus. Instead, they terminate onto the paramedian pontine reticular formation (PPRF). The PPRF contains excitatory “burst” neurons that transmit the pulse to the ipsilateral (the same side of the body) abducens nucleus.
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Also, fibers to the paramedian pontine reticular formation mediates the movements with the oculomotor (III) and trochlear (IV) nerves through the medial longitudinal fasciculus (MLF). The MLF coordinates the interaction between the oculomotor (III) and the abducens (VI) nuclei, which create bilateral conjugate horizontal eye movements.
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In the course of the lymph, lymphocytes may be activated as part of the adaptive immune response. There is usually only one efferent vessel though sometimes there may be two. Medullary sinuses contain histiocytes (immobile macrophages) and reticular cells. A lymph node contains lymphoid tissue, i.e.
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G, Magoun HW. Brain stem reticular formation and activation of the EEG. Electroencephalog Clin neurophysiol 1949;1:455–73 In humans, light flashes have been observed to disturb the sleep-like EEG activity persisting after the loss of all brainstem reflexes and of spontaneous respiration.Zwarts MJ, Kornips FHM.
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Although it is mostly reported from Japan, it is reported also from other countries. It is characterized by itchy red papules over the trunk and neck, which fade leaving reticular pigmentation. This disorder has been more common in adult females. About one third respond to Dapsone.
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Lesions in the brain stem can cause visual hallucinations. Visual hallucinations are frequent in those with certain sleep disorders, occurring more often when drowsy. This suggests that the reticular activating system plays a part in visual hallucinations, although the precise mechanism has still not fully been established.
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Other colors, e.g. yellow and brown, can be present in the sample; they are caused by intrinsic pigments such as melanin. Basal laminae need to be stained by PAS stain or some silver stains, if they have to be well visible. Reticular fibers also require silver stain.
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Reticular dysgenesis (RD) is a rare, inherited autosomal recessive disease that results in immunodeficiency. Individuals with RD have mutations in both copies of the AK2 gene. Mutations in this gene lead to absence of AK2 protein. AK2 protein allows hematopoietic stem cells to differentiate and proliferate.
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Thalamic cells synapse on apical dendrites of pyramidal cells in the cortex. These pyramidal cells reciprocally synapse back on thalamic neurons. Each loop is self-contained and modulated by sensory input. Inhibitory interneurons both in the cortex and the reticular nucleus of the thalamus regulate circuit activity.
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The outer cortex consists of groups of mainly inactivated B cells called follicles. When activated, these may develop into what is called a germinal centre. The deeper paracortex mainly consists of the T cells. Here the T-cells mainly interact with dendritic cells, and the reticular network is dense.
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Yang, CC et al. Excitatory innervation of caudal hypoglossal nucleus from nucleus reticularis gigantocellularis in the rat. Neuroscience. 1995 Mar;65(2):365-74. It additionally receives connections from the periaqueductal gray, the paraventricular hypothalamic nucleus, central nucleus of the amygdala, lateral hypothalamic area, and parvocellular reticular nucleus.
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A liver biopsy stained using the reticulin demonstrating the normal hepatic plate thickness and mild steatosis. In pathology, the reticulin stain, is a popular staining method in histology. It is used to visualize reticular fiber and used extensively in liver histopathology.Lefkowitch JH. Special stains in diagnostic liver pathology.
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In some cases stroke and transient ischemic attacks have occurred after sclerotherapy. Varicose veins and reticular veins are often treated before treating telangiectasia, although treatment of these larger veins in advance of sclerotherapy for telangiectasia may not guarantee better results.Treatment of Leg Veins. Procedures in Cosmetic Dermatology Series.
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Other brainstem sites, such as the parabrachial nucleus, the dorsal raphe, locus coeruleus, and the medullary reticular formation also mediate pain relief and use many different neurotransmitters to either facilitate or inhibit activity of the neurons in the dorsal horn. These neurotransmitters include noradrenaline, serotonin, dopamine, histamine, and acetylcholine.
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He was among the first to study the dynamics of the brain during sleep, and one of his key discoveries was determining the role of thalamic reticular neurons as pacemakers in producing the sleep spindle rhythm. He also discovered slow (<1 Hz) sleep rhythms associated with intracortical activity.
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The term gaze is frequently used in physiology to describe coordinated motion of the eyes and neck. The lateral gaze is controlled by the paramedian pontine reticular formation (PPRF). The vertical gaze is controlled by the rostral interstitial nucleus of medial longitudinal fasciculus and the interstitial nucleus of Cajal.
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Columnar crystal habit "Gypsum flower" speleothem, Mammoth Cave Kentucky. Orange color is iron oxide from groundwater. Crystal habit refers to the shapes that crystals exhibit. Selenite crystals commonly occur as tabular, reticular, and columnar crystals, often with no imperfections or inclusions, and thereby can appear water or glass-like.
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EST can have a multitude of morphologic patterns including: reticular, endodermal sinus-like, microcystic, papillary, solid, glandular, alveolar, polyvesicular vitelline, enteric and hepatoid. Schiller-Duval bodies on histology are pathognomonic and seen in the context of the endodermal sinus-like pattern. Rarely, it can be found in the vagina.
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The forewings have a reticular pattern with brownish-grey streaks in the discal area. There is a brown streak from the base to the costa and a small semicircular brown spot. The hindwings are uniform grey., 2011: Two new species of the goat moths (Lepidoptera, Cossidae) from New Guinea.
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However, their interpretation of discoveries were directly in opposition. Much as Golgi made significant contributions to the techniques in the study of nervous system in terms of actual structure, he made a completely erroneous conclusion that nervous system is nothing but a single continuous network, the notion called reticular theory. On the other hand, Ramón y Cajal described nervous system as composed of interlinking nerve cells or neurons as suggested by a theory called the neuron doctrine. Golgi strongly advocated the reticular theory such that even his Nobel lecture was a direct attack on Cajal's work and the neuron doctrine, and even depicted a diagram of continuous network which he claimed was "an exact reproduction after life".
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Reticular pigmented anomaly of the flexures (also known as "dark dot disease", and "Dowling–Degos' disease") is a fibrous anomaly of the flexures or bending parts of the axillae, neck and inframammary/sternal areas.James, William; Berger, Timothy; Elston, Dirk (2005). Andrews' Diseases of the Skin: Clinical Dermatology. (10th ed.). Saunders. .
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Lee EH, et al. Multiple inhibitory actions of the paramedian reticular nucleus—effects on blood pressure and motor activities in rats. Chin J Physiol. 1990;33(1):49–61. The paramedian nuclei on either side of the brain stem have been shown to mediate the horizontal eye movements on their ipsilateral sides.
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Group A8 is a small group of dopaminergic cells in rodents and primates. It is located in the midbrain reticular formation dorsolateral to the substantia nigra at the level of the red nucleus and caudally. In the mouse it is identified with the retrorubral field as defined by classical stains.
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Varun has co-founded three startups, Alma Mater, an online store for merchandise especially for students of colleges and schools which was started in 2009, Reticular, a social media marketing company started in 2010, and Last minute Films, a production company for online video content which was started in 2005.
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Oxford University Press. Eysenck looked at the ascending reticular activating system (ARAS) for answering questions about personality. The ARAS is part of the brain structure and has been proposed to deal with cortical arousal, hence the term arousal theory. Eysenck compared levels of arousal to a scale of introversion versus extraversion.
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Oropharyngeal candidiasis (also known as thrush) is a common infection that has a predilection for infants, older adults with dentures, immunosuppressed individuals, and individuals utilizing intraoral corticosteroid therapy. Patients present with white plaques or erythematous patches on the buccal mucosa, palate, tongue, or oropharynx that may be mistaken for reticular LP.
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Mesenchyme is characterized morphologically by a prominent ground substance matrix containing a loose aggregate of reticular fibers and unspecialized mesenchymal stem cells.Mesenchymal tissue Mesenchymal cells can migrate easily, in contrast to epithelial cells, which lack mobility, are organized into closely adherent sheets, and are polarized in an apical-basal orientation.
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The spores are as spore mass ochre to olive brown, in transmitted light faint-coloured. They are round and have a diameter from 5 to 7 µm, but distydian pellets are generally absent. Its surface is sharply sculptured and occasionally produces a reticular structure. In transmitted light they appear finely thorned.
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Dermal dendrocyte hamartoma is characterized by a rounded, medallion-like lesion on the upper trunk in which there is a proliferation of fusiform CD34, factor XIIIa-positive cells in the mid and reticular dermis.James, William; Berger, Timothy; Elston, Dirk (2005). Andrews' Diseases of the Skin: Clinical Dermatology. (10th ed.). Saunders. .
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Mass lesions in brainstem ARAS nuclei can cause severe alterations in level of consciousness (e.g., coma). Bilateral damage to the reticular formation of the midbrain may lead to coma or death. Direct electrical stimulation of the ARAS produces pain responses in cats and elicits verbal reports of pain in humans.
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Chest decorations included several circles of necklaces. Special circular collars had a hard base which was covered with canvas and embroidered with glass beads, buttons and chains. Also there were reticular breast-collars made of red glass-beads and copper buttons. They finally matched perfectly with a huge embroidery of «panar» and «ruca».
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Plum and Swanson suggested that failure to inhibit the activity of this particular region of the brain results in continuous stimulation of the respiratory center by the lateral pontile reticular formulation and laterally located descending neural pathway. The destruction of this required negative feedback mechanism causes the uncontrollable hyperventilation associated with CNH.
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1996 Aug;49(5):481-515. In particular, the reticular formation in the pons plays an important role in inducing locomotion. The parapyramidal region (PPR) in the ventral medulla is also known to produce locomotion when stimulated in neonatal rats. Several different command pathways play a role in the initiation of locomotion.
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Peduncular hallucinosis therefore might emanate from disturbances in distal portions of the visual system. Lesions in the frontal and temporal lobes can also lead to complex visual hallucinations because the lobes connect to the visual system via the lateral geniculate nucleus and medial pulvinar. In addition, visual processing and salience can be disrupted by thalamic lesions which affect important structures such as the pulvinar. The effect lesions on the brainstem have on the ascending reticular activating system (ARAS) has also been hypothesized. It was proposed that since the ARAS plays a role in consciousness and waking, the lesions of the brainstem common to peduncular hallucinosis may “disrupt ARAS impulses from the brainstem reticular formation” and, as a consequence, lead to the sleep disturbances characteristic of peduncular hallucinosis.
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Ramón y Cajal's illustration of the neuronal morphologies in the auditory cortex In 1877 an English physiologist Edward Schäfer described the absence of connections between the nerve elements in the mantles of the jellyfish. The Norwegian zoologist Fridtjof Nansen also reported in 1887 that he found no connections between the processes of the ganglion cells of aquatic animals in his doctoral research (The Structure and Combination of Histological Elements of the Central Nervous System). By the late 1880s, serious opposition to the reticular theory began to emerge. Wilhelm His in Leipzig studied the embryological development of the central nervous system and concluded that his observations were consistent with the classic cell theory (that nerve cells were individual cells), and not the reticular theory.
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As direct electrical stimulation of the brain could simulate electrocortical relays, Magoun used this principle to demonstrate, on two separate areas of the brainstem of a cat, how to produce wakefulness from sleep. He first stimulated the ascending somatic and auditory paths; second, a series of "ascending relays from the reticular formation of the lower brain stem through the midbrain tegmentum, subthalamus and hypothalamus to the internal capsule." The latter was of particular interest, as this series of relays did not correspond to any known anatomical pathways for the wakefulness signal transduction and was coined the ascending reticular activating system (ARAS). Next, the significance of this newly identified relay system was evaluated by placing lesions in the medial and lateral portions of the front of the midbrain.
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Accessory abducens nucleus is a small cluster of neurons in the pontine reticular formation of the rat and rabbit. In the rabbit, motoneurons that are involved in the nictitating membrane response are found in the accessory abducens nucleus. Crosby et al. (1962) questioned whether, in the human, it exists independently of the accessory facial nucleus.
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The blood vessels in the dermis provide nourishment and waste removal from its own cells as well as from the stratum basale of the epidermis. The dermis is structurally divided into two areas: a superficial area adjacent to the epidermis, called the papillary region, and a deep thicker area known as the reticular region.
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These tubes sometimes branch forming a network that is reticular in appearance. In some cells, there are dilated areas like the sacs of rough endoplasmic reticulum. The network of smooth endoplasmic reticulum allows for an increased surface area to be devoted to the action or storage of key enzymes and the products of these enzymes.
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The rumen and reticulum are very close in structure and function and can be considered as one organ. They are separated only by a muscular fold of tissue. In immature ruminants a reticular groove is formed by the muscular fold of the reticulum. This allows milk to pass by the reticulorumen straight into the abomasum.
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Logorrhea has been shown to be associated with traumatic brain injuries in the frontal lobe as well as with lesions in the thalamus and the ascending reticular inhibitory system and has been associated with aphasia. Logorrhea can also result from a variety of psychiatric and neurological disorders including tachypsychia, mania, hyperactivity, catatonia, and schizophrenia.
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The usual appearance of portal hypertensive gastropathy on endoscopy is a mosaic- like or reticular pattern in the mucosa. Red spots may or may not be present. The pattern is usually seen throughout the stomach. A similar pattern can be seen with a related condition called gastric antral vascular ectasia (GAVE), or watermelon stomach.
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Dyskeratosis is abnormal keratinization occurring prematurely within individual cells or groups of cells below the stratum granulosum.Kumar, Vinay; Fausto, Nelso; Abbas, Abul (2004) Robbins & Cotran Pathologic Basis of Disease (8th ed.). Saunders. Page 1392. . Dyskeratosis congenita is congenital disease characterized by reticular skin pigmentation, nail degeneration, and leukoplakia on the mucous membranes associated with short telomeres.
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Tar melanosis is an occupational dermatosis that occurs among tar handlers after several years of exposure, characterized by a severe widespread itching that is soon followed by the appearance of reticular pigmentation, telangiectases, and a shiny appearance of the skin.James, William; Berger, Timothy; Elston, Dirk (2005). Andrews' Diseases of the Skin: Clinical Dermatology. (10th ed.). Saunders. .
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In addition to the pathology observed in Stage 1, Stage 2 is characterized by additional lesions in the raphe nuclei and gigantocellular reticular nucleus of the medulla oblongata. The disease then moves up the brainstem, traveling from the medullary structures to the locus ceruleus in the pontine tegmentum. Similar to Stage 1, Lewy neurites outnumber Lewy bodies.
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Noradrenergic cell group A7 is a group of cells fluorescent for norepinephrine that is located in the pontine reticular formation ventral to the superior cerebellar peduncle of the pons in rodentsDahlstrom A; Fuxe K (1964). "Evidence for the existence of monoamine-containing neurons in the central nervous system". Acta Physiologica Scandinavica 62:1-55. and in primates.
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Eur J Neurosci. 2003 May;17(10):2156-62. The caudal pontine reticular nucleus is also thought to play a role in the grinding of teeth during sleep. The region also suppresses muscle tone during REM sleep, activates eye movements, and decreases the sensory input to the cerebral cortex, specifically the primary and sensory somatosensory cortices.
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Peduncular Hallucinosis - a Syndrome of Impaired Reality Monitoring. Journal of Neurology, 253(12), 1561-1571. Peduncular hallucinosis has been described as a “release phenomenon” due to damage to the ascending reticular activating system, which is supported by the sleep disturbance characteristic of this syndrome. In most cases, people are aware that the hallucinations are not real.
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High quality data was recorded throughout the flight, other than the reticular measurements and data recorded during reentry. Electrical shocks were administered to C341 at a higher rate than intended. She was vigilant during the ascent phase, due to being a payload in a rocket. During the microgravity phase, her heart rate slowed and her breathing became nominal.
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Delta waves can arise either in the thalamus or in the cortex. When associated with the thalamus, they are thought to arise in coordination with the reticular formation.Maquet, P., Degueldre, C., Delfiore, G., Aerts, J., Peters, J. M., Luxen, A., et al. (1997). Functional neuroanatomy of human slow wave sleep. Journal of Neuroscience, 17(8), 2807-2812.
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Lesions involving the reticular dermis, may be out of the reach of pulsed-dye laser, cautery or shave excision and therefore have a recurrence rate of 43.5%. Definitive management requires full-thickness skin excision. Other options are currettage or laser therapy. Furthermore, thorough currettage and cauterization are often used for small lesions and full-thickness excision for larger lesion.
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He was a specialist in neuroanatomy, and was particularly interested in the cerebellum, the reticular substance and the vestibular nuclei. He worked closely with Jan Birger Jansen. His books include Nevro-anatomi i relasjon til klinisk nevrologi (1943), the translation Neurological Anatomy in Relation to Clinical Medicine (1st edition 1948),(2d edition 1969,(3d edition 1981) and Centralnervesystemet (1949).
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It is involved in the special sense of vision and sends its superior brachium to the lateral geniculate body of the diencephalon. The tegmentum which forms the floor of the midbrain, is ventral to the cerebral aqueduct. Several nuclei, tracts, and the reticular formation are contained here. The ventral tegmental area (VTA) is composed of paired cerebral peduncles.
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Models of horizontal eye movements: Part I: Early models of Saccades and smooth pursuit. S.l.: Morgan & Claypool. Several centers in the brainstem are involved. Horizontal conjugate gaze is controlled by the nuclei of the Ocular Nerve, CN III, and the Abducens nerve, CN VI, the paramedian pontine reticular formation, and the nucleus prepositus hypoglossi-medial vestibular nucleus.
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Zhao and Y.-G. Jiang. 2010. A new oogenus of Elongatoolithidae from the Upper Cretaceous Chichengshan Formation of Tiantai Basin, Zhejiang Province. Vertebrata PalAsiatica 48(2):111-118 The outer surface of its shell is decorated with nodes and ridges arranged into a net-like, or reticular, pattern. The eggshell is 0.5-0.6 mm thick, excluding the ornamentation.
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Palatine tonsils consist of approximately 15 crypts, which result in a large internal surface. The tonsils contain four lymphoid compartments that influence immune functions, namely the reticular crypt epithelium, the extrafollicular area, the mantle zones of lymphoid follicles, and the follicular germinal centers. In human palatine tonsils, the very first part exposed to the outside environment is tonsillar epithelium.
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This is in agreement with a previous study that showed a selective increase in the T-type conductance in GAERS nRT neurons.Tsakiridou, E., Bertollini, L., deCurtis, M., Avanzini, G., Pape, H.C., 1995. Selective increase in T-Type calcium conductance of reticular thalamic neurons in a rat model of absence epilepsy. Journal of Neuroscience 15, 3110–3117.
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Reticular neurons (RE), on the other hand, are highly interconnected and have their own intrinsic oscillatory properties. These neurons are capable of inhibiting thalamocortical activity via their direct connections to TCs. Corticothalamic neurons are the cortical neurons that TC neurons synapse on. These cells are glutaminergic excitatory cells that exhibit increasing activity as they become more depolarized.
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Antigen-presenting cells accumulate near high endothelial venules to process soluble antigens. Antigens are also presented on the surface of dendritic cells. In an inflammatory state, lymphatic endothelial cells increase their surface adhesion molecules, and dendritic cells express a surface CCR7 receptor. This type of receptor interacts with the chemokine CCL21, produced by fibroblastic reticular cells.
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The reticular nature of signaling cascades necessitates that the downstream effectors of ICAM-1 mediated signaling through various kinases including p56lyn, Raf-1, and the MAPKs are largely unknown. A more thorough study of the cross-talk between these signaling molecules may shed further light onto the biological endpoints produced by ICAM-1 ligation and signal transduction.
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American Journal of Physiology Regulator Integratory Comp Physiology. Volume 297, Issue 5, November 2009, Pages R1400-8. The nucleus raphe magnus receives descending afferents from the periaqueductal grey matter (PAG), the paraventricular hypothalamic nucleus, central nucleus of the amygdala, lateral hypothalamic area, parvocellular reticular nucleus and the prelimbic, infralimbic, medial and lateral precentral cortices.Hermann, Dirk M. et al.
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The raphe nuclei are the place of synthesis of the neurotransmitter serotonin, which plays an important role in mood regulation. The gigantocellular nuclei are involved in motor coordination. The parvocellular nuclei regulate exhalation. The reticular formation is essential for governing some of the basic functions of higher organisms and is one of the phylogenetically oldest portions of the brain.
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The amygdala sends projections to the hypothalamus, the dorsomedial thalamus, the thalamic reticular nucleus, the nuclei of the trigeminal nerve and the facial nerve, the ventral tegmental area, the locus coeruleus, and the laterodorsal tegmental nucleus. The basolateral amygdala projects to the nucleus accumbens, including the medial shell. Coronal section of brain through intermediate mass of third ventricle. Amygdala is shown in purple.
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Lennox–Gastaut syndrome is often associated with intellectual deficits as well as a lack of response to anti-epileptic drugs. It usually begins in the first years of life. Reticular reflex myoclonus is a generalized form of epilepsy originating from the brain stem. Jerks associated with the disorder can affect all muscles on the body or be selective in certain areas.
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Livedoid vasculopathy is a chronic cutaneous disease seen predominantly in young to middle-aged women. One acronym used to describe its features is "Painful purpuric ulcers with reticular pattern of the lower extremities" (PURPLE). It can be divided into a primary (or idiopathic) form and a secondary form, which has been associated with a number of diseases, including chronic venous hypertension and varicosities.
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The large N-terminal hydrophilic domains and the small C-terminal hydrophilic domains are localized to the cytoplasm. Mammals possess at least three isoforms which probably arose by gene duplication and divergence before divergence of the mammalian species. Homologues are present in Drosophila melanogaster and Caenorabditis elegans. Tetrameric cardiac and skeletal muscle sarcoplasmic reticular ryanodine receptors (RyR) are large (~2.3 MDa).
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Collagen is a structural protein, often referred to as “the steel of biological materials”. There are multiple types of collagen: Type I (comprising skin, tendons and ligaments, vasculature and organs, as well as teeth and bone); Type II (a component in cartilage); Type III (often found in reticular fibers); and others. Collagen has a hierarchical structure, forming triple helices, fibrils, and fibers.
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Life cycle of Stemonitis sp. (Stemonitales) The spores of Myxogastria are haploid, mainly round and measure between 5 µm and 20 µm, rarely up to 24 µm in diameter. Their surface is generally reticular, sharp, warty or spiky and very rarely smooth. The typical colour of the spore mass becomes visible through the structure, since the spores themselves are not pigmented.
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In the earlier stages of actinic elastosis, elastic fiber proliferation can be seen in the dermis. As the condition becomes more established, the collagen fibers of the papillary dermis and reticular dermis become increasingly replaced by thickened and curled fibers that form tangled masses and appear basophilic under routine haematoxylin and eosin staining. These fibers stain black with the Verhoeff stain.
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The stroma of the ovary is a unique type of connective tissue abundantly supplied with blood vessels, consisting for the most part of spindle-shaped stroma cells. These appear similar to fibroblasts. The stroma also contains ordinary connective tissue such as reticular fibers and collagen. Ovarian stroma differs from typical connective tissue in that it contains a high number of cells.
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Meprobamate binds to GABAA receptors which interrupts neuronal communication in the reticular formation and spinal cord, causing sedation and altered perception of pain. Meprobamate has the ability to activate currents even in the absence of GABA. This relatively unique property makes meprobamate exceptionally dangerous when used in combination with other GABA-mediated drugs (including alcohol). It is also a potent adenosine reuptake inhibitor.
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Circadian rhythms also play a part in the reticular activating system, which is crucial for maintaining a state of consciousness. A reversal in the sleep–wake cycle may be a sign or complication of uremia, azotemia or acute kidney injury. Studies have also shown that light has a direct effect on human health because of the way it influences the circadian rhythms.
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The LGN receives input from the retina and many other brain structures, especially visual cortex. The principal neurons in the LGN receive strong inputs from the retina. However, the retina only accounts for a small percentage of LGN input. As much as 95% of input in the LGN comes from the visual cortex, superior colliculus, pretectum, thalamic reticular nuclei, and local LGN interneurons.
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Patients with subacute HP gradually develop a productive cough, dyspnea, fatigue, anorexia, weight loss, and pleurisy. Symptoms are similar to the acute form of the disease, but are less severe and last longer. On chest radiographs, micronodular or reticular opacities are most prominent in mid-to- lower lung zones. Findings may be present in patients who have experienced repeated acute attacks.
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The pathogenesis of erythema ab igne remains unknown. It has been proposed that thermal radiation exposure can induce damage to superficial blood vessels that subsequently leads to epidermal vascular dilation. The dilation of vessels presents morphologically as the initially observed erythema. Red blood cell extravasion and deposition of hemosiderin that follows clinically appears as hyperpigmentation, which can occur in a reticular distribution.
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New York: Plenum. In particular, the three-factor model identifies the reticular system and the limbic system in the brain as key components that mediate cortical arousal and emotional responses respectively. Eysenck advocates that extraverts have low levels of cortical arousal and introverts have high levels, leading extraverts to seek out more stimulation from socializing and being venturesome.Eysenck, H.J. (1967).
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Although Golgi's earlier works between 1873 and 1885 clearly depicted the axonal connections of cerebellar cortex and olfactory bulb as independent of one another, his later works including the Nobel Lecture showed the entire granular layer of the cerebellar cortex occupied by a network of branching and anastomosing nerve processes. This was due to his strong conviction in the reticular theory.
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Ramón y Cajal even commented that: "What a cruel irony of fate to pair, like Siamese twins united by the shoulders, scientific adversaries of such contrasting character!". In the 1950s electron microscopy finally confirmed the existence of individual neurons in the central nervous system, and the existence of gaps in between neurons called synapse. The reticular theory was finally put to rest.
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All etiologies lead to local dermal lymphostasis pathogenesis. A maximum variation was observed after the resection of block subcutaneous tissue in patients suffering from congenital lymphedema. Signals that the current condition are different, either in the dermis or in the subcutaneous area. In dermis, principal signs found are precollectors initial nodes, injection tank, the reticular distribution, cutaneous reflexes, and lymphatic cysts.
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In molecular biology mir-708 microRNA is a short RNA molecule. MicroRNAs function to regulate the expression levels of other genes by several mechanisms. miR-708 is located on chromosome 11q14.1 and is endcoded in intron 1 of the ODZ4 gene. It is most highly expressed in the brain and eyes, and has a supposed role in endoplasmic reticular stress of the eye.
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But the idea of the "universal city" the artist will later on call "Olospolis"– that may be compared to the western "counter-architecture"– had been locally accepted due to its exulting a symbolic structure having its origin in the ancient peasant wooden architecture. In Ragon's book, in the chapter about a new type of architecture referring to new techniques, he read about A. Foppl's old notion of "reticular structure"(1882), Graham Bell's experimenting in Canada with "floating" structures composed tetrahedrons, and about Robert Le Ricolais' essay on reticular systems in three dimensions, as a new language in architecture. The tridimensional, or bi-, tri- or quadri-directional structures realized of different materials have a knot which is the key element of spatial structures. The idea, as important as it had been, brought no fame and recognition to the unknown French architect (b.
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Loose connective tissue is a category of connective tissue which includes areolar tissue, reticular tissue, and adipose tissue. Loose connective tissue is the most common type of connective tissue in vertebrates. It holds organs in place and attaches epithelial tissue to other underlying tissues. For example, it forms telae, such as the tela submucosa and tela subserosa, which connect mucous and serous membranes to the muscular layer.
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Those synapse ipsilaterally in the reticular formation, then via the inferior and middle peduncles into the cerebellar vermis. The motor cortex and somatosensory cortex projects onto the ipsilateral inferior and accessory olivary nuclei, then forming the olivocerebellar tract. Cortico-olivary fibers synapse bilaterally in the inferior olivary nucleus. The order is preserved in the olivocerebellar tract projections onto the ‘body maps’ in the contralateral cerebellar cortex.
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The terminal wall holds a large late-Gothic window divided into four lights by mullions. Its head is filled with reticular tracery. This window must in the 15th century have replaced an earlier smaller Romanesque window. In front of this window stands the table of the high altar, the front of which is divided into nine panels decorated with late-gothic cusped arches and foliage in relief.
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The perception of mental fatigue is believed to be modulated by the brain's reticular activating system (RAS). Fatigue impacts a driver's reaction time, awareness of hazards around them and their attention. Drowsy drivers are three times more likely to be involved in a car crash and if they are awake over 20 hours, is the equivalent of driving with a blood-alcohol concentration level of 0.08%.
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Koch 2004, p. 92 These structures therefore enable and control brain arousal (as determined by metabolic or electrical activity) and are necessary neural correlates. One such example is the heterogeneous collection of more than two dozen nuclei on each side of the upper brainstem (pons, midbrain and in the posterior hypothalamus), collectively referred to as the reticular activating system (RAS). Their axons project widely throughout the brain.
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Mebicar (mebicarum) is an anxiolytic produced in Latvia and used in Eastern Europe. Mebicar has an effect on the structure of limbic-reticular activity, particularly on hypothalamus emotional zone, as well as on all 4 basic neuromediator systems – γ aminobutyric acid (GABA), choline, serotonin and adrenergic activity. Mebicar decreases the brain noradrenaline level, exerts no effect on the dopaminergic systems, and increases the brain serotonin level.
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Although a coma patient may appear to be awake, they are unable to consciously feel, speak, hear, or move. For a patient to maintain consciousness, two important neurological components must function impeccably. The first is the cerebral cortex which is the gray matter covering the outer layer of the brain. The other is a structure located in the brainstem, called reticular activating system (RAS or ARAS).
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They set and maintain the rate of respiration. Most of the neurons are located in the nucleus of the solitary tract. Other important neurons are found in the adjacent areas including the reticular substance of the medulla. The solitary nucleus is the end-point for sensory information arriving from the pontine respiratory group, and from two cranial nerves – the vagus nerve, and the glossopharyngeal nerve.
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These connections are both excitatory and inhibitory. Neurons send excitatory fibers to neurons in the thalamus and also send collaterals to the thalamic reticular nucleus that inhibit these same thalamus neurons or ones adjacent to them. One theory is that because the inhibitory output is reduced by cholinergic input to the cerebral cortex, this provides the brainstem with adjustable "gain control for the relay of lemniscal inputs".
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Gamma motor neurons are also involved through their action on intrafusal muscle fibers. The intrafusal muscle fibers control the resting level of the Ia afferent pathway, which in turn creates a steady level of alpha neuron activity. Muscle tone can also be due to tonic discharge of gamma motor neurons. The activation to these neurons are mostly from the descending fibers of the facilitatory reticular formation.
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Like alpha motor neurons, their cell bodies are located in the anterior grey column of the spinal cord. They receive input from the reticular formation of the pons in the brainstem. Their axons are smaller than those of the alpha motor neurons, with a diameter of only 5 μm. Unlike the alpha motor neurons, gamma motor neurons do not directly adjust the lengthening or shortening of muscles.
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It also creates a porous molecular sieve in the lymph node. The lymph carries chemokines (molecular chemical messengers) and antigens to the lymph node. At the lymph node, the lymph passes quickly through the reticular network to the T cell zone and the high endothelial venules. FRCs express chemokines such as CCL21 and CCL19 which assist the movement of T cells and dendritic cells with CCR7 receptors.
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FRCs also produce components of extracellular matrix, such as ER-TR7, fibrillin, laminin, fibronectin and intracellular components such as desmin and α-actin smooth muscle that may influence the formation of the reticular fiber network. For example, the chemokine CCL21 attaches to the surface of the FRCs through collagen and glycosaminoglycan molecules. FRCs express cytokine IL-7, a regulator of the survival of resting T lymphocytes.
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Ground-glass opacity seen on CT caused by hypersensitivity pneumonitis, not flock worker's lung. This type of abnormality is commonly seen in flock worker's lung. Signs and symptoms of flock worker's lung include rales (crackling noises caused by fluid in the lungs), dyspnea (shortness of breath), and coughing. Abnormalities seen on a computed tomography (CT) scan of the lungs can include ground glass opacity and reticular opacity.
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Many pretectal nuclei share targets of efferent projections. All pretectal nuclei, except for the ON, project to nuclei in the thalamus, subthalamus, superior colliculus, reticular formation, pons, and inferior olive. Both the ON and the CPA have efferent projections to the Edinger- Westphal nucleus. The NPP and NPA both project to the pulvinar, the lateral posterior nucleus of the thalamus, and several precerebellar nuclei.
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Modern scientists usually refer to the individual nuclei that compose the reticular formation. Moruzzi and Magoun first investigated the neural components regulating the brain's sleep-wake mechanisms in 1949. Physiologists had proposed that some structure deep within the brain controlled mental wakefulness and alertness. It had been thought that wakefulness depended only on the direct reception of afferent (sensory) stimuli at the cerebral cortex.
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Patients with Reis-Bücklers dystrophy develop a reticular pattern of cloudiness in the cornea. This cloudiness, or opacity, usually appears in both eyes (bilaterally) in the upper cornea by 4 or 5 years of age. The opacity elevates the corneal epithelium, eventually leading to corneal erosions that prompt attacks of ocular hyperemia, pain, and photophobia. These recurrent painful corneal epithelial erosions often begin as early as 1 year of age.
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Giuseppe Moruzzi (July 30, 1910 – March 11, 1986) was an Italian neurophysiologist. He was one of three scientists who connected wakefulness to a series of brain structures known as the reticular activating system, and his work reframed sleep as an active process in the brain rather than a passive one. He received the Karl Spencer Lashley Award from the American Philosophical Society and the Feltrinelli Prize from the Accademia dei Lincei.
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Ramón y Cajal in his laboratory. Ramón y Cajal made several major contributions to neuroanatomy. He discovered the axonal growth cone, and demonstrated experimentally that the relationship between nerve cells was not continuous, or a single system as per then extant reticular theory, but rather contiguous; there were gaps between neurons. This provided definitive evidence for what Heinrich Waldeyer would name "neuron theory", now widely considered the foundation of modern neuroscience.
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Since carbachol is poorly absorbed through topical administration, benzalkonium chloride is mixed in to promote absorption. Carbachol is a parasympathomimetic that stimulates both muscarinic and nicotinic receptors. In topical ocular and intraocular administration its principal effects are miosis and increased aqueous humour outflow. In the cat and rat, carbachol is well known for its ability to induce rapid eye movement (REM) sleep when microinjected into the pontine reticular formation.
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Upper and lower septal necks are recumbent or narrowly free. The canal system is reticular, characteristic of the Wutinoceratidae.Flower R.H.,1968;The First Great Expansion of the Actinoceroids, New Mexico Bureau of Mines and Mineral Resources, Memoir 19 Part I, Socorro NM Cyrtonybyoceras and Wutinoceras are similar, except for Cyrtonybyoceras being slightly cyrtoconic, and almost intergrade. Cyrtonybyoceras is so far known only from the Whiterock Stage in North America.
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The fibers of the corticomesencephalic tracts are involved in the control of the conjugate eye movement. The fibers to the oculomotor (III) nucleus control the medial rectus, superior rectus, inferior rectus, and inferior oblique muscles. Fibers to the trochlear (IV) nucleus control the superior oblique muscle. Fibers to the paramedian pontine reticular formation (PPRF) project to the abducens (VI) nucleus, which controls the movement of the lateral rectus muscle.
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The tower was built of large, red monk bricks and ornamented with a reticular pattern of dark burned bricks. Between 1880-1885 the rampart area around Jarmers Tower was excavated and the moat leveled in connection with the Nordic Exhibition of 1888. Jarmers Tower was subsequently restored and preserved as a ruin. The plaza built around the excavation where Nørre Voldgade becomes H.C. Andersens Boulevard has been named Jarmers Plads.
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Figure 3: Cross- section of the cochlea. Outer hair cells (OHCs) contribute to the structure of the Organ of Corti, which is situated between the basilar membrane and the tectorial membrane within the cochlea (See Figure 3). The tunnel of corti, which runs through the Organ of Corti, divides the OHCs and the inner hair cells (IHCs). OHCs are connected to the reticular laminar and the Deiters’ cells.
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Epithelial reticular cells, or epithelioreticular cells (ERC), some called thymic epithelial cell (TEC), are a structure in both the cortex and medulla of the thymus. However, histologically, they are more easily identified in the medulla. These cells contain secretory granules which are thought to contain the thymic hormones. There are six different types: Types 1-3 are in the cortex, and types 4-6 are in the medulla.
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The righting reflex involves complex muscular movements in response to a stimulus. When startled, the brain can evoke anticipatory postural adjustments, or a series of muscle movements, which involves the function of the midbrain. However, the mechanisms of such an origin are yet to be elucidated. Data support the generation of these movements from circuits in the spine connected to the supplementary motor area, the basal ganglia, and the reticular formation.
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However, as Cajal points out, though Waldeyer "supported the theory with the prestige of his authority, he did not contribute a single personal observation. He limited himself to a short brilliant exposition of the objective proofs, adduced by His, Kölliker, Retzius, van Gehuchten and myself, and he invented the fortunate term neuron." Cajal, S. Ramón y. (1954) Neuron theory or reticular theory: Objective evidence of the anatomical unity of nerve cells.Transl.
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Another research in the field of sleep, Batini, questioned Bremer's hypothesis and did an experiment similar to Bremers'. In 1939 Batini's experiment performed his experiment in which he stimulated of different areas of the reticular activating system, and his results concluded that sleep is not dependent on an influx or lack of stimulus from the body. Our bodies do not require input to have or maintain evidence of being awake.
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It is proposed that CCL2 and RANTES act as autocrine loop in human osteoclast differentiation. The CCL2 chemokine is also expressed by neurons, astrocytes and microglia. The expression of CCL2 in neurons is mainly found in the cerebral cortex, globus pallidus, hippocampus, paraventricular and supraoptic hypothalamic nuclei, lateral hypothalamus, substantia nigra, facial nuclei, motor and spinal trigeminal nuclei, gigantocellular reticular nucleus and in Purkinje cells in the cerebellum.
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Trichoblastomas are a cutaneous condition characterized by benign neoplasms of follicular germinative cells. Trichoblastic fibroma is a designation used to characterize small nodular trichoblastomas with conspicuous fibrocytic stroma, sometimes constituting over 50% of the lesion. left Image at left shows a trichoblastoma from a 68-year-old Caucasian male. It shows a pseudo- encapsulated, multinodular, basaloid tumor with fibrocellular stroma spanning the reticular dermis extending into subcutaneous fat (A).
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The amygdala is an almond-shaped group of nuclei found deep and medially within the temporal lobes of the brain. Known to be the area of the brain responsible for emotional reaction, but plays an important role in processing of memory and decision making as well. It is part of the limbic system. The amygdala projects to various structures in the brain including the hypothalamus, the thalamic reticular nucleus, and more.
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Reticular fiber is composed of one or more types of very thin and delicately woven strands of type III collagen. These strands build a highly ordered cellular network and provide a supporting network. Many of these types of collagen have been combined with carbohydrate. Thus, they react with silver stains and with periodic acid-Schiff reagent but are not demonstrated with ordinary histological stains such as those using hematoxylin.
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The reticular nucleus of the thalamus, for example, is a thin layer of inhibitory neurons that surrounds the thalamus. Some of the major anatomical components of the brain are organized as clusters of interconnected nuclei. Notable among these are the thalamus and hypothalamus, each of which contains several dozen distinguishable substructures. The medulla and pons also contain numerous small nuclei with a wide variety of sensory, motor, and regulatory functions.
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The EEG arousal response to auditory stimulation and to electric stimulation of the mesencephalic reticular formation, posterior hypothalamus and centromedian thalamus is significantly suppressed. The photic driving response elicited by a flash light in the visual cortex is also suppressed by nitrazepam. Estazolam was found to be more potent however. Nitrazepam increases the slow wave light sleep (SWLS) in a dose-dependent manner whilst suppressing deep sleep stages.
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In common with the aforementioned reticular system the thalamus is involved in wakefullness and consciousness, such as though the SCN. The hypothalamus engages in functions of a number of primitive emotions or feelings such as hunger, thirst and maternal bonding. This is regulated partly through control of secretion of hormones from the pituitary gland. Additionally the hypothalamus plays a role in motivation and many other behaviors of the individual.
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The scleredema is usually proposed as a diagnosis based on the appearance of the skin and the patient's medical history. To confirm the diagnosis, the doctor performs a skin biopsy, in which hematoxylin and eosin staining will show a thick reticular dermis with thick collagen bundles separated by clear spaces. The patient's blood may be examined for diseases that may appear after the onset of symptoms, such as multiple myeloma.
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Human Myeloblasts Myeloblasts reside extravascularly in the bone marrow. Hematopoiesis takes place in the extravascular cavities between the sinuses of the marrow. The wall of the sinuses is composed of two different types of cells, endothelial cells and adventitial reticular cells. The hemopoietic cells are aligned in cords or wedges between these sinuses, with myeloblasts and other granular progenitors concentrated in the subcortical regions of these hemopoietic cords.
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Descending tracts are the axons of upper motor neurons destined to synapse on lower motor neurons in the ventral horn and posterior horn. In addition, there are upper motor neurons that originate in the brainstem's vestibular, red, tectal, and reticular nuclei, which also descend and synapse in the spinal cord. # The cranial nerves III-XII emerge from the brainstem. These cranial nerves supply the face, head, and viscera.
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As glycosaminoglycans are produced, water is drawn in between the cells, stretching them apart. As they are moved further away from one another, the stellate reticular cells maintain contact with one another through desmosomes, resulting in their unique appearance. The stellate reticulum is lost after the first layer of enamel is laid down. This brings cells in the inner enamel epithelium closer to blood vessels at the periphery.
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Fibronectin is a glycoprotein that is believed to act as a template for the oriented deposition of the collagen fibers, stabilizing the collagen fibrils. Fibronectin also acts as a skeleton for the elastic tissue formation. Reticular and collagenous fibers were seen to run along the edges of the VF throughout the entire lamina propria. Fibronectin in the Reinke's space appeared to guide those fibers and orient the fibril deposition.
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He wrote a seminal paper describing a technique to record the electrical responses of deep brain structures to sensory stimuli such as a flash of light or a loud sound. The paper is highly cited, having been referenced in 384 articles by January 2019.Starzl TE, Taylor CW, Magoun HW. Collateral Afferent Excitation of Reticular Formation of Brain Stem. Journal of Neurophysiology, Nov 1951 In 1959, he gained a Markle scholarship.
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Other causes of congenital neutropenia are Shwachman–Diamond syndrome, Cyclic neutropenia, bone marrow failure syndromes, cartilage–hair hypoplasia, reticular dysgenesis, and Barth syndrome. Viruses that infect neutrophil progenitors can also be the cause of neutropenia. Viruses identified that have an effect on neutrophils are rubella and cytomegalovirus. Though the body can manufacture a normal level of neutrophils, in some cases the destruction of excessive numbers of neutrophils can lead to neutropenia.
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Urbanization became more elaborated as well, with reticular street design in sites like La Hoya (Biasteri, Araba). The Atlantic basin remains less developed and purely rural but there are many coincidences with the south. There are many sites, especially in the Northern Basque Country, that are awaiting archaeological excavation. The economy became more and more centered in agriculture, specially cereals, with less importance of cattle and a marginal role for hunt.
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The biochemical mechanism of action of general anaesthetics is not well understood. Theories need to explain the function of anaesthesia in animals and plants. To induce unconsciousness, anaesthetics have myriad sites of action and affect the central nervous system (CNS) at multiple levels. Common areas of the central nervous system whose functions are interrupted or changed during general anaesthesia include the cerebral cortex, thalamus, reticular activating system, and spinal cord.
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The DLF ascending tract has its origins in nuclei of the reticular formation. These fibers synapse onto the hypothalamus and carry visceral information to the brain. Brainstem afferents in DLF include fibers coming from the parabrachial area, which conveys taste & general visceral sensation to the hypothalamus from the nucleus of the tractus solitarius in the medulla. Afferents distribute to the posterior nucleus and periventricular nuclei of the hypothalamus.
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Due to this interaction, dendritic cells move to the T cell zone or to the B cell follicle along the fibroblast reticular cell network. Dendritic cells exhibit C-type lectin receptors (CLEC-2), which bind to gp38 on the surface of lymphatic endothelial cells. Lymphocytes leave the lymph node, as effector immune cells, via the efferent lymph vessels. Their numbers compensate for the removal of dead peripheral lymphocytes.
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Atto Tigri (22 May 1813 - 1875) was an Italian anatomist born in Pistoia. He studied medicine in Pistoia and at the University of Pisa, where he became an assistant to Filippo Civinini (1805–1844). Later he was a professor of human and comparative anatomy at the University of Siena. In the late 1840s, Tigri is credited for providing the first comprehensive description of the reticular tissue of the spleen, which he called trama microscopica.
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Adamsoceras is a genus of actinocerids of the family Wutinoceratidae, with spheroidal siphuncle segments like Ormoceras, but having a reticular canal system like Wutinoceras. Adamsoceras has a slender, gently expanding, orthoconic shell that is slightly broader than high, i.e. depressed, with close spaced septa that form ventral lobes and a siphuncle that is near the ventral margin. Adamsoceras is known from rocks of Whiterockian age (early Middle Ordovician) in Nevada, the Baltic, Tasmania, and Manchuria.
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The lumen is filled with lymphatic fluid, but often contains red blood cells, lymphocytes, macrophages, and neutrophils. The channels are lined with flat endothelial cells. The interstitium has many lymphoid cells and shows evidence of fibroplasia (the formation of fibrous tissue). Nodules (A small mass of tissue or aggregation of cells) in cavernous lymphangioma are large, irregular channels in the reticular dermis and subcutaneous tissue that are lined by a single layer of endothelial cells.
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PYY is found in L cells in the mucosa of gastrointestinal tract, especially in ileum and colon. Also, a small amount of PYY, about 1-10%, is found in the esophagus, stomach, duodenum and jejunum. PYY concentration in the circulation increases postprandially (after food ingestion) and decreases by fasting. In addition, PYY is produced by a discrete population of neurons in the brainstem, specifically localized to the gigantocellular reticular nucleus of the medulla oblongata.
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In biology, a whorl is a cluster of cells or tissue that surrounds another and wraps around another in an expanding circular pattern. Whorls occur at the ends of different structures or in the middle of structures. Structures of some organs are often described as whorls and used in the aid of identification. The Hassall's corpuscle, formed from type VI epithelial reticular cells in the thymus, is an example of a whorl-shaped structure.
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Reductions in arousal generally correspond to reductions in vigilance. Arousal is defined as a component of vigilance, though it is not, as one may believe, the sole source of the main effect of the vigilance decrement.Moruzzi, G. and Magoun, H.W. (1949) Brain stem reticular formation and activation of the EEG. EEG Clinical Neurophysiology I: 455-473 As such, subcortical brain regions associated with arousal play a critical role in the performance of vigilance tasks.
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These neurons are located throughout the reticular formation as well as the lumbar ventral roots of the spinal cord. Stimulating the MLR produces postsynaptic potentials (PSP) in motoneurons with an average conduction velocity of 88 m/s, which indicates that this is a myelinated glutamatergic pathway.Noga, B.R., Kriellaars, D.J., Brownstone, R.M., Jordan, L.M. Mechanism for activation of locomotor centers in the spinal cord by stimulation of the mesencephalic locomotor region. J. Neurophysiol.
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There are different kinds of TBI that cause different brain dysfunctions. Research suggests that TBI results in damage to sleep-regulation centers including the reticular activation system, specifically damage to the suprachiasmatic nuclei (SCN) which leads to disturbances in the circadian rhythm. Considering hypersomnia, mostly areas involving the maintenance of wakefulness are damaged, such as the rostral pons, caudal midbrain and thalamus. Sleep disorders are more frequently reported when patients suffer from mild TBI (mTBI).
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Polidocanol is also used as a sclerosant, an irritant injected to treat varicose veins, under the trade names Asclera, AethoxysklerolSclerotherapy, Laurence Z Rosenberg, MD, eMedicine.com and Varithena. Polidocanol causes fibrosis inside varicose veins, occluding the lumen of the vessel, and reducing the appearance of the varicosity. The FDA has approved polidocanol injections for the treatment of small varicose (less than 1 mm in diameter) and reticular veins (1 to 3 mm in diameter).
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These tracts regulate the sensitivity of flexor responses to ensure that only noxious stimuli elicit the responses. The reticular formation also contains circuitry for many complex actions, such as orienting, stretching, and maintaining a complex posture. Commands that initiate locomotor circuits in the spinal cord are also transmitted through the medullary reticulospinal tract. Thus, the reticulospinal tracts are involved in many aspects of motor control, including the integration of sensory input to guide motor output.
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Striate arteries or ganglionic arteries arise from the middle cerebral artery and supply deep structures in the cerebrum, including the internal capsule and reticular formation. Strokes in these vessels are common and can cause extensive damage. This is because emboli are carried up the carotid and tend to be swept into the MCA, sometimes called the "artery of stroke", and are prone to getting stuck at this branch point in the lateral sulcus.
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Sadick N, Sorhaindo L, Laser Treatment of Telangiectatic and Reticular Veins, Ch 16, p157. The Vein Book / editor, John J. Bergan, 2007. Unlike a laser, the sclerosing solution additionally closes the "feeder veins" under the skin that are causing the spider veins to form, thereby making a recurrence of the spider veins in the treated area less likely. Multiple injections of dilute sclerosant are injected into the abnormal surface veins of the involved leg.
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Sequenced NSCC2 family proteins are 283-402 amino acyl residues in length and exhibit two putative transmembrane α-helical segments (TMSs). The S. cerevisiae protein, of 283 amino acyl residues, has cytoplasmic N- and C-termini with two putative TMSs at positions 159-178 and 193-213. The C-terminal 25 residues are rich in arginine and lysine. These proteins have been reported to be present in both endoplasmic reticular and cytoplasmic membranes.
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Parvalbumin is present in some GABAergic interneurons in the nervous system, especially the reticular thalamus, and expressed predominantly by chandelier and basket cells in the cortex. In the cerebellum, PV is expressed in Purkinje cells and molecular layer interneurons. In the hippocampus, PV+ interneurons are subdivided into basket, axo-axonic, and bistratified cells, each subtype targeting distinct compartments of pyramidal cells.free full text PV interneurons' connections are mostly perisomatic (around the cell body of neurons).
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The septum is considered a part of the limbic system, mediating the connection between the cortex and subcortical limbic nuclei. The septum projects fibres to the hypothalamus, hippocampus, amygdala, reticular formation and olfactory cortical areas, suggesting a role in limbic regulation. While the exact function remains controversial, the septum is considered a pleasure zone in animals, studies have shown that stimulation of the septal area can bring feelings of satisfaction to euphoria and damage can cause hyperactivity and fury.
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The brainstem also contains many cranial nerve nuclei and nuclei of peripheral nerves, as well as nuclei involved in the regulation of many essential processes including breathing, control of eye movements and balance. The reticular formation, a network of nuclei of ill-defined formation, is present within and along the length of the brainstem. Many nerve tracts, which transmit information to and from the cerebral cortex to the rest of the body, pass through the brainstem.
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The effects of sleep deprivation show the absolute need for sleep. The lateral hypothalamus contains orexinergic neurons that control appetite and arousal through their projections to the ascending reticular activating system. The hypothalamus controls the pituitary gland through the release of peptides such as oxytocin, and vasopressin, as well as dopamine into the median eminence. Through the autonomic projections, the hypothalamus is involved in regulating functions such as blood pressure, heart rate, breathing, sweating, and other homeostatic mechanisms.
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The dermis is the middle layer of skin, composed of dense irregular connective tissue and areolar connective tissue such as a collagen with elastin arranged in a diffusely bundled and woven pattern. The dermis has two layers. One is the papillary layer which is the superficial layer and consists of the areolar connective tissue. The other is the reticular layer which is the deep layer of the dermis and consists of the dense irregular connective tissue.
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The lesions that disturb brainstem reticular formation or thalamic targets seem to be the source behind peduncular hallucinosis. For example, lesions affecting the dorsal raphe system can lead to hallucinations by preventing ascending inhibition to the dorsal lateral geniculate nucleus (LGN). This inhibition may hyper-excite the LGN, inducing visual hallucinations. Lesions of the retina and areas proximal to it can remove or alter the inputs coming in from the external environment to the visual system.
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This occurs as a result of the development cycle of the bacteria. The reticular body is basically the structure in which the chlamydial genome is transcribed into RNA, proteins are synthesized, and the DNA is replicated. The reticulate body divides by binary fission to form particles which, after synthesis of the outer cell wall, develop into new infectious elementary body progeny. The fusion lasts about three hours and the incubation period may be up to 21 days.
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Many adjacent epithelial tissues (which are avascular) get their nutrients from the interstitial fluid of areolar tissue; the lamina propria is areolar in many body locations. Its fibers run in random directions and are mostly collagenous, but elastic and reticular fibers are also present. Areolar tissue is highly variable in appearance. In many serous membranes, it appears as a loose arrangement of collagenous and elastic fibers, scattered cells of various types; abundant ground substance; numerous blood vessels.
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Mossy fibers are one of the major inputs to cerebellum. There are many sources of this pathway, the largest of which is the cerebral cortex, which sends input to the cerebellum via the pontocerebellar pathway. Other contributors include the vestibular nerve and nuclei, the spinal cord, the reticular formation, and feedback from deep cerebellar nuclei. Axons enter the cerebellum via the middle and inferior cerebellar peduncles, where some branch to make contact with deep cerebellar nuclei.
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Often they are performed in surgical suites or in professional medical centers. Since the procedure can typically remove the top to deeper layers of the epidermis, and extend into the reticular dermis, there is always minor skin bleeding. The procedure carries risks of scarring, skin discoloration, infections, and facial herpes virus (cold sore) reactivation. In aggressive dermabrasion cases, there is often tremendous skin bleeding and spray during the procedure that has to be controlled with pressure.
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Stage I yolk sac tumors are highly treatable, with a 5-year disease- free survival rate of 93%, but stage II-IV tumors are less treatable, with survival rates of 64–91%. Their gross appearance is solid, friable, and yellow, with necrotic and hemorrhagic areas. They also often contain cysts that can degenerate or rupture. Histologically, yolk sac tumors are characterized by the presence of Schiller-Duval bodies (which are pathognomonic for yolk sac tumors) and a reticular pattern.
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Donald Benjamin Lindsley (December 23, 1907 – June 19, 2003) was a physiological psychologist most known as a pioneer in the field of brain function study. Considered by his colleagues to have been worthy of winning the Nobel Prize in Physiology for discovering the reticular activating system along with Horace Winchell (Tid) Magoun and Giuseppe Moruzzi, Lindsley was instrumental in demonstrating the use of electroencephalography (EEG) in the study of brain function.Chalupa, L.M. (2005). Obituaries: Donald B. Lindsley.
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What Beritashvili called the neuropil is the structure, which is now well known as the reticular formation. Sadly, his four papers on this problem were published only in Soviet journals and the world physiological community did not pay them proper attention. In 1949 Horace Winchell Magoun and Giuseppe Moruzzi rediscovered and described this phenomenon precisely. While studying single reflex contractions of muscles in cats in 1941, Beritashvili demonstrated, independently of B. Renshow, the antidromic inhibitory effect.
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One study reported an improvement in lesions in 46% of patients within 3 years. If CMTC persists into adulthood, it can result in complaints due to paresthesia, increased sensitivity to cold and pain, and the formation of ulcers. Few reports included long-term follow up of CMTC into adolescence and adulthood. While about 50% of patients seem to show definite improvement in the reticular vascular pattern, the exact incidence and cause of persistent cases are unknown.
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Although originally thought to stem from spontaneous firing of motor units, the origin of ocular microtremors is now believed to be in the oculomotor nuclei in the reticular formation of the brainstem. This new insight opened the possibility of using ocular tremors as a gauge for neuronal activity in that region of the central nervous system. More research must be done, but recent studies strongly suggest that decreased activity in the brainstem correlates with decreased frequency of OMTs.
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Each rhombomere can cause a repeated pattern of rhombomere-specific neurons, including reticulospinal neurons, many of which share properties such as mediolateral location. Reticulospinal neurons also occupy different areas in rhombomeres in different species. It was found in one study that reticular neurons in the lamprey hindbrain, which included isthmic, bulbar, and Mauthner cells, developed in conserved rhombomere- specific positions, similar to those in the zebrafish. In different species, however, reticulospinal neurons occupy different areas in rhombomeres.
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The output neurons of the nucleus accumbens send axonal projections to the basal ganglia and the ventral analog of the globus pallidus, known as the ventral pallidum (VP). The VP, in turn, projects to the medial dorsal nucleus of the dorsal thalamus, which projects to the prefrontal cortex as well as the striatum. Other efferents from the nucleus accumbens include connections with the tail of the ventral tegmental area, substantia nigra, and the reticular formation of the pons.
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Because the amygdala plays an important role in the recognition of emotional stimuli, it appears to be an important brain structure in the regulation of vigilance. Subcortical brain regions associated with arousal include the basal forebrain cholinergic system, and the locus coeruleus (LC) noradrenergic system.Parasuraman, R., Warm, J. & See, J. (1998) Brain Systems of Vigilance in The Attentive Brain R. Parasuraman (Ed.) pp. 221–256. Cambridge MA: MIT Press Both regions are components of the reticular activating system (RAS).
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Hensen's stripe is the section of the tectorial membrane above the inner hair cell. Nuel's spaces refer to the fluid-filled spaces between the outer pillar cells and adjacent hair cells and also the spaces between the outer hair cells. Hardesty's membrane is the layer of the tectoria closest to the reticular lamina and overlying the outer hair cell region. Reissner's membrane is composed of two cell layers and separates the scala media from the scala vestibuli.
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Golgi refused to accept the neuron theory and hung on to the reticular theory. Golgi and Ramón y Cajal were jointly awarded the 1906 Nobel Prize for Physiology or Medicine, but the controversy between the two scientists continued. The matter was finally resolved in 1950s with the development of electron microscopy by which it was unambiguously demonstrated that nerve cells were individual cells interconnected through synapses to form a nervous system, thereby validating the neuron theory.
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Between the borders of the striae and skin, there are curled, broken, reticular elastic fibres sometimes present. These symptoms are responsible for cobweblike skin appearances in patients with MFS. Management of MFS is to operate on the individual through open heart surgery. Management of MFS includes standard implications such as counselling on lifestyle to reduce and restrict physical activity, endo prophylaxis, serial imaging the aorta, ß-blocker medication for aortic protection and prophylactic replacement of the aortic root.
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He described an extremely dense and intricate network, composed of a web of intertwined branches of axons coming from different cell layers ("diffuse nervous network"). This network structure, which emerges from the axons, is essentially different from that hypothesized by Gerlach. It was the main organ of the central nervous system according to Golgi. Thus, Golgi presented the reticular theory which states that the brain is a single network of nerve fibres, and not of discrete cells.
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The blood–thymus barrier regulates exchange of substances between the circulatory system and thymus, providing a sequestered environment for immature T cells to develop. The barrier also prevents the immature T cells from contacting foreign antigens (since contact with antigens at this stage will cause the T cells to die by apoptosis). The barrier is formed by the continuous blood capillaries in the thymic cortex, reinforced by type 1 epithelial reticular cells (sometimes called thymic epithelial cells) and macrophages.
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The latter pathways are analogous to the spinomesencephalic and spinoreticular tracts of the spinal cord, which send pain-temperature information from the rest of the body to the same areas. The mesencephalon modulates painful input before it reaches the level of consciousness. The reticular formation is responsible for the automatic (unconscious) orientation of the body to painful stimuli. Incidentally, Sulfur-containing compounds found in plants in the onion family stimulate receptors found in trigeminal ganglia, bypassing the olfactory system.
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Vestibulo-ocular reflex The disorder is caused by injury or dysfunction in the medial longitudinal fasciculus (MLF), a heavily myelinated tract that allows conjugate eye movement by connecting the paramedian pontine reticular formation (PPRF)-abducens nucleus complex of the contralateral side to the oculomotor nucleus of the ipsilateral side. In young patients with bilateral INO, multiple sclerosis is often the cause. In older patients with one-sided lesions a stroke is a distinct possibility. Other causes are possible.
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Thalamic nuclei. Metathalamus labelled MTh Nuclei of the thalamus Dorsal view Coronal section of lateral and third ventricles Derivatives of the diencephalon include the dorsally-located epithalamus (essentially the habenula and annexes) and the perithalamus (prethalamus) containing the zona incerta and the thalamic reticular nucleus. Due to their different ontogenetic origins, the epithalamus and the perithalamus are formally distinguished from the thalamus proper. The metathalamus is made up of the lateral geniculate and medial geniculate nuclei.
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The dermis or corium is a layer of skin between the epidermis (with which it makes up the cutis) and subcutaneous tissues, that primarily consists of dense irregular connective tissue and cushions the body from stress and strain. It is divided into two layers, the superficial area adjacent to the epidermis called the papillary region and a deep thicker area known as the reticular dermis.James, William; Berger, Timothy; Elston, Dirk (2005). Andrews' Diseases of the Skin: Clinical Dermatology (10th ed.). Saunders.
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The reproductive organs include an anterior genital atrium armed with a crown of 13 hooks, a cirrus bulbous projecting into genital atrium, armed with a crown of slender spines, one row of ventrosubmarginal vaginae on each side of the body, each row divided into a longitudinal row of transverse slit-like areolae with heavily cuticularized margins, and each row is connected with the reticular vitelline ducts of its own side, an ovary, and 40-65 large testes pre, para and post-ovarian.
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Many types of problems can cause a coma. Forty percent of comatose states result from drug poisoning. Certain drug use under certain conditions can damage or weaken the synaptic functioning in the ascending reticular activating system (ARAS) and keep the system from properly functioning to arouse the brain. Secondary effects of drugs, which include abnormal heart rate and blood pressure, as well as abnormal breathing and sweating, may also indirectly harm the functioning of the ARAS and lead to a coma.
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Myoclonus dystonia has been characterized under subcortical origin, specifically under nonsegmented myoclonus or brainstem myoclonus. Symptoms within this classification include the startle response and reticular reflex myoclonus. Sudden stimuli like noise or touch to areas around the head or chest cause the startle response which will go up the brain stem and down the spinal cord causing jerk-like movements. Hyperekplexia is a heightened brainstem response where an affected person will continue to elicit the same response to a repeated stimuli.
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Sasaki S, The neural control of orienting: role of multiple-branching reticulospinal neurons. Prog Brain Res. 2004;143:383-9. The neurons in the dorsal half of this nucleus fire rhythmically during mastication, and in an anesthetized animal it is possible to induce mastication via electrical stimulation of the nucleus reticularis pontis caudalis or adjacent areas of the gigantocellular nucleus.Scott G, Effect of lidocaine and NMDA injections into the medial pontobulbar reticular formation on mastication evoked by cortical stimulation in anaesthetized rabbits.
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The deepest layer of epidermis also contains nerve endings. Beneath this, the dermis comprises two sections, the papillary and reticular layers, and contains connective tissues, vessels, glands, follicles, hair roots, sensory nerve endings, and muscular tissue.The Ageing Skin - Structure of Skin The deepest layer, the hypodermis, is primarily made up of adipose tissue. Substantial collagen bundles anchor the dermis to the hypodermis in a way that permits most areas of the skin to move freely over the deeper tissue layers.
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In contrast to the perpetual sleep state, the lower transection simply caused and alteration of sleep and wake cycle that was not different from a regular cat. This strengthened his belief in his hypothesis. Although unaware of the reticular activating system, discovered 14 years later by Giuseppe Moruzzi and Horace Magoun, Bremer attributed the sleep-wake cycle to the effects of sensory input to the brain. He concluded that sleep is simply a manifestation of a decrease in cortical "tone".
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The thalamic reticular nucleus is considered to be the pacemaker of the sleep spindles. This has been further substantiated by the fact that rhythmic stimulation of the thalamus leads to increased secondary depolarization in cortical neurons, which further results in the increased amplitude of firing, causing self-sustained activity. The sleep spindles have been predicted to play a role in disconnecting the cortex from sensory input and allowing entry of calcium ions into cells, thus potentially playing a role in Plasticity.
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LNSCs are generally divided into several sub-populations based on the expression of gp38 (PDPN) and CD31 surface markers. Among those, only fibroblastic reticular cells and lymph node stromal cells were shown to play a role in the peripheral tolerance. Both of those populations are able to induce CD8 T cell tolerance by presentation of the endogenous antigens on MHCI molecules and even the CD4 T cell tolerance by the presentation of the peptide-MHCII complexes, which they acquired from the DCs.
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Unfortunately one still sees cases of uncomplicated retinoschisis treated by laser retinopexy or cryopexy in an attempt to stop its progression towards the macula. Such treatments are not only ineffective but unnecessarily risk complications. There is no documented case in the literature of degenerative retinoschisis itself (as opposed to the occasional situation of retinal detachment complicating retinoschisis) in which the splitting of the retina has progressed through the fovea. There is no clinical utility in differentiating between typical and reticular retinoschisis.
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Paolo Mazzarello, Alberto Calligaro, Vanio Vannini and Umberto Muscatello The sarcoplasmic reticulum: its discovery and rediscovery Nature Reviews Molecular Cell Biology 4, 69-74 (January 2003) doi:10.1038/nrm1003 In March 1902, he provided the first accurate description of the reticular network (sarcoplasmic reticulum) in skeletal muscle fibers. His published findings attracted little attention at the time, and as years passed by, his discovery was all but forgotten. In 1961 "Veratti's reticulum" was re-discovered through the use of electron microscopy.
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The locus coeruleus (LC) (\\-si-ˈrü-lē-əs\\), also spelled locus caeruleus or locus ceruleus, is a nucleus in the pons of the brainstem involved with physiological responses to stress and panic. It is a part of the reticular activating system. The locus coeruleus is the principal site for brain synthesis of norepinephrine (noradrenaline). The locus coeruleus and the areas of the body affected by the norepinephrine it produces are described collectively as the locus coeruleus-noradrenergic system or LC-NA system.
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Possible causes of opsoclonus include neuroblastoma and encephalitis in children, and breast, lung, or ovarian cancer in adults. Other considerations include multiple sclerosis, toxins, medication effects (e.g. Serotonin Syndrome), celiac disease, certain infections (West Nile virus, Lyme disease), non-Hodgkin lymphoma, and renal adenocarcinoma. It can also be caused by a lesion in the omnipause neurons which tonically inhibit initiation of saccadic eye movement (until signaled by the superior colliculus) by blocking paramedian pontine reticular formation (PPRF) burst neurons in the pons.
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The middle peduncle is the largest of the three and its afferent fibers are grouped into three separate fascicles taking their inputs to different parts of the cerebellum. The inferior cerebellar peduncle receives input from afferent fibers from the vestibular nuclei, spinal cord and the tegmentum. Output from the inferior peduncle is via efferent fibers to the vestibular nuclei and the reticular formation. The whole of the cerebellum receives modulatory input from the inferior olivary nucleus via the inferior cerebellar peduncle.
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Among the handful of cases that Evers and Ellgers studied, major lesion sites included the temporal cortex; however, the specific location and laterality (left vs. right temporal cortex) was variable. Many cases of focal brain lesions had comorbidity with hearing impairment (see hypoacusis), epileptic activity and intoxication. There have also been several findings of acute musical hallucinations in patients with dorsal pons lesions post-stroke and encephalitis potentially due to disruption of connections between the sensory cortex and reticular formation.
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The rough endoplasmic reticulum and Golgi apparatus, as shown by electron micrographs, are not well developed, indicating that the cells are in a resting phase. The collagenous and reticular fibers in the newborn VF are fewer than in the adult one, adding to the immaturity of the vocal fold tissue. In the infant, many fibrous components were seen to extend from the macula flava towards the Reinke's space. Fibronectin is very abundant in the Reinke's space of newborn and infant.
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The dermis is the layer of skin between the epidermis and subcutaneous tissue, and comprises two sections, the papillary dermis and the reticular dermis. The superficial papillary dermis interdigitates with the overlying rete ridges of the epidermis, between which the two layers interact through the basement membrane zone. Structural components of the dermis are collagen, elastic fibers, and ground substance also called extra fibrillar matrix. Within these components are the pilosebaceous units, arrector pili muscles, and the eccrine and apocrine glands.
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Finally, some fibers are sent to the intralaminar nucleus (IL) of the thalamus via the reticular formation. The IL projects diffusely to all parts of the cerebral cortex. The insular and cingulate cortices are parts of the brain which represent touch-position and pain-temperature in the context of other simultaneous perceptions (sight, smell, taste, hearing and balance) in the context of memory and emotional state. Peripheral pain-temperature information is channeled directly to the brain at a deep level, without prior processing.
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Neural networks that regulate arousal and sleep comprise a bottom-up (from the brainstem to the cortex) pathway and a top-down (corticothalamic) pathway. The bottom-up pathway emerges from the ascending reticular arousal system (ARAS) and activates the cortex via well-characterized thalamic and nonthalamic pathways through cholinergic and aminergic neurotransmission. The bottom-up pathway represents the leverage point for pharmaceutical interventions. It is complemented by a corticothalamic top-down pathway, which appears to be modifiable through noninvasive brain stimulation (NIBS) techniques.
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Reticulocytes are immature red blood cells (RBCs). In the process of erythropoiesis (red blood cell formation), reticulocytes develop and mature in the bone marrow and then circulate for about a day in the blood stream before developing into mature red blood cells. Like mature red blood cells, in mammals, reticulocytes do not have a cell nucleus. They are called reticulocytes because of a reticular (mesh-like) network of ribosomal RNA that becomes visible under a microscope with certain stains such as new methylene blue and Romanowsky stain.
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It is a multisynaptic network of neurons that is involved in many subconscious homeostatic and reflexive pathways. It is a motor center that relays inhibitory signals to the thalamus and basal nuclei preventing unwanted body movement. The tegmentum area includes various different structures, such as the rostral (=frontal/cranial/oral) end of the reticular formation, several nuclei controlling eye movements, the periaqueductal gray matter, the red nucleus, the substantia nigra, and the ventral tegmental area. The tegmentum is the location of several cranial nerve (CN) nuclei.
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The pathway fibers travel up the spinal cord and connect with second-order neurons in the reticular formation of the brainstem for pain and temperature, and also terminate at the ventrobasal complex of the thalamas for gross touch. Vision is generated by light that hits the retina of the eye. Photoreceptors in the retina transduce the sensory stimulus of light into an electrical nerve signal that is sent to the visual cortex in the occipital lobe. Visual signals leave the retinas through the optic nerves.
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Owing to its large size and distinctive structure, the Golgi apparatus was one of the first organelles to be discovered and observed in detail. It was discovered in 1898 by Italian physician Camillo Golgi during an investigation of the nervous system. After first observing it under his microscope, he termed the structure as apparato reticolare interno ("internal reticular apparatus"). Some doubted the discovery at first, arguing that the appearance of the structure was merely an optical illusion created by the observation technique used by Golgi.
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To the contrary, Metropolitan Reticular Matrix Planning analyzes that most metropolises develop in a particular geographical site, a strategic location for economic and social relations.Febvre, Lucien (1925): A Geographical Introduction to History. in collaboration with Lionel Bataillon, London. (Originally published in Paris in 1922 as La Terre et l'évolution humaine : introduction géographique à l'histoire.) A strategic location is one that has a comparative advantage mostly related to a point of transition between two geographical systems: the comparative advantage at the border between two ecosystems.
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Oakland, USA: New Harbinger Publications Inc. • Setting an objective to be mindful – at the start of an activity that requires concentration, establishing a deliberate objective to remain focused, such as "I am going to let my mind be steady." • Remaining awake and alert to the environment - the brain cannot pay attention when sleep-deprived. For example, sitting up in a straight posture helps as this sends information to the reticular formation, which is involved in consciousness, telling it to stay vigilant to environmental stimuli.
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It also surrounds the blood vessels and nerves. Cells called fibroblasts are widely dispersed in this tissue; they are irregular branching cells that secrete strong fibrous proteins and proteoglycans as an extracellular matrix. The cells of this type of tissue are generally separated by quite some distance by a gelatinous substance primarily made up of collagenous and elastic fibers. Usually "loose connective tissue" is considered a parent category that includes the mucous connective tissue of the fetus, areolar connective tissue, reticular connective tissue, and adipose tissue.
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Mukherjee's team is also known for defining and characterizing skeletal stem/progenitor cells (also called osteochondroreticular or OCR cells). In 2015, they prospectively identified these progenitor cells from bone, and showed, using lineage tracing, that these cells can give rise to bone, cartilage, and reticular cells (hence the term "OCR" cells). They established that these cells form a part of the adult skeleton in vertebrates, and that they maintain and repair the skeleton. OCR cells are among the newest progenitor cells to be defined in vertebrates.
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Pneumocystis pneumonia can present with interstitial lung disease, as seen in the reticular markings on this AP chest x-ray. A chest X-ray demonstrating pulmonary fibrosis due to amiodarone Investigation is tailored towards the symptoms and signs. A proper and detailed history looking for the occupational exposures, and for signs of conditions listed above is the first and probably the most important part of the workup in patients with interstitial lung disease. Pulmonary function tests usually show a restrictive defect with decreased diffusion capacity (DLCO).
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Lindsley was one of the first in his field to utilize electroencephalography (EEG) to record brain activity. He developed a means for measuring human sensory processing and rapid electrical changes in the brain. He contributed to understanding wakefulness and arousal in relation to brainstem activating systems. He developed an interdisciplinary approach to researching the psychological variables associated with the reticular activating systemHuang, C.C. Polysensory responses and sensory interaction in pulvinar and related postero-lateral thalamic nuclei in cat. Electroen. Clin. Neuro. 34:265-270.
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Decerebration is the elimination of cerebral brain function in an animal by removing the cerebrum, cutting across the brain stem, or severing certain arteries in the brain stem. As a result, the animal loses certain reflexes that are integrated in different parts of the brain. Furthermore, the reflexes which are functional will be hyperreactive (and therefore very accentuated) due to the removal of inhibiting higher- brain centers (e.g. the facilitatory area of the reticular formation will not receive regulating input from cerebellum, basal ganglia and the cortex).
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The abundantly produced spores are stored in a reticular or filamentous structure – the so-called capillitium – and are found on nearly all species except Liceida and other species from the genus Echinostelium. When the open fruit bodies have dried, the spores are dispersed by wind or by small animals such as woodlice, mites or beetles, which either pick up the spores through contact with the fruit bodies or ingest and then excrete them. Dispersal by running water is also possible, but it plays a minor role.
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A. Blanton (Personal Communication, March 11, 2009). The superficial layer of the lamina propria is a structure that vibrates a great deal during phonation, and the viscoelasticity needed to support this vibratory function depends mostly on extracellular matrices. The primary extracellular matrices of the vocal fold cover are reticular, collagenous and elastic fibers, as well as glycoprotein and glycosaminoglycan. These fibers serve as scaffolds for structural maintenance, providing tensile strength and resilience so that the vocal folds may vibrate freely but still retain their shape.
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This feature is unique to Influenza C virus particles. Even when HEF is removed from the membrane, the polymeric reticular structure that it originally had can still be seen. These results indicate that the hexagonal arrangement is an intrinsic feature of HEF and does not require other viral proteins such as M1 and that its formation likely involves lateral interaction between the ectodomains of HEF. The formation of the spike arrangement in virus particles acts like a coat around the virus particle by creating and covering it.
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This centre sends descending projections to lower motor neurones of the limbs. In slightly more detail this corresponds to ear (cochlea) → cranial nerve VIII (auditory) → cochlear nucleus (ventral/inferior) → LLN → caudal pontine reticular nucleus (PnC). The whole process has a less than 10ms latency. There is no involvement of the superior/rostral or inferior/caudal colliculus in the reaction that "twitches" the hindlimbs, but these may be important for adjustment of pinnae and gaze towards the direction of the sound, or for the associated blink.
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Distant homologues include the Lec15/Lec35 suppressor, SL15, of Chinese hamster ovary cells and ERS1, the ERD suppressor in S. cerevisiae. Both of these suppressors, when overexpressed, have been reported to influence retention of lumenal endoplasmic reticular proteins as well as glycosylation in the Golgi apparatus. The Lec15 and Lec35 mutations are characterized by inefficient synthesis and utilization, respectively, of mannose-P-dolichol for glycolipid biosynthesis. All proteins in the LCT family are distantly related to the proteins of the microbial rhodopsin (MR) family (TC #3.
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An organelle in eukaryotice cells now known as Golgi apparatus or Golgi complex, or sometimes simply as Golgi, was discovered by Camillo Golgi. Golgi modified his black reaction using osmium dichromate solution with which he stained the nerve cells (Purkinje cells) of the cerebellum of an owl. He noticed thread-like networks inside the cells and named them apparato reticolare interno (internal reticular apparatus). Recognising them to be unique cellular components, he presented his discovery before the Medical- Surgical Society of Pavia in April 1898.
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The LGN is a small, ovoid, ventral projection at the termination of the optic tract on each side of the brain. The LGN and the medial geniculate nucleus which deals with auditory information are both thalamic nuclei and so are present in both hemispheres. The LGN receives information directly from the ascending retinal ganglion cells via the optic tract and from the reticular activating system. Neurons of the LGN send their axons through the optic radiation, a direct pathway to the primary visual cortex.
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It is thought that the forces from the injury disrupt the normal cellular activities in the reticular activating system located in these areas and that this disruption produces the loss of consciousness often seen in concussion. Other areas of the brain that may be affected include the upper part of the brain stem, the fornix, the corpus callosum, the temporal lobe, and the frontal lobe. Angular accelerations of 4600, 5900, or 7900 rad/s2 are estimated to have 25, 50, or 80% risk of mTBI respectively.
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Trimeperidine produces similar effects to other opioids, such as analgesia and sedation, along with side effects such as nausea, itching, vomiting and respiratory depression which may be harmful or fatal. Trimeperidine is in Schedule I of the Controlled Substances Act 1970 of the United States as a Narcotic with ACSCN 9646 with an annual aggregate manufacturing quota of 2 grammes as of 2014. The free base conversion ratio for salts includes 0.883 for the hydrochloride. Promedol increases the activity of the reticular activating system in the brain.
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In addition to the cytokines and cell signaling molecules mentioned above, the HSC niche in the bone marrow provides soluble factors, forces, and cell-mediated interactions necessary to maintain the hematopoietic potential of the stem cells located there. This niche is generally separated into 2 sections: #Endosteal niche-the outer edge of the bone marrow that contains osteocytes, bone matrix, and quiescent HSCs. #Perivascular niche-the inner core of the bone marrow that contains actively dividing HSCs, sinusoidal endothelium, CARs (CXCL12-abundant reticular cells), and MSCs (Mesenchymal stem cells).
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The dentatothalamic fibers also cross over and ascend to synapse in the ventral intermediate (VI) and ventral anterior (VA) nuclei of the thalamus. The fastigioreticular fibers enter the reticular formation of the midbrain, pons, and medulla oblongata. Afferent pathways include the anterior spinocerebellar and tectocerebellar tracts. The fibers of the anterior spinocerebellar tract originate in Clarke's column of the spinal cord and cross in the anterior white commissure to the lateral funiculus, where they ascend to upper pontine levels before crossing back to enter the cerebellum through the superior peduncle.
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A given set of splits can have more than one representation thus internal nodes may not be ancestors and are only an "implicit" representation of evolutionary history as distinct from the "explicit" representation of phylogenetic networks. In a splits network the phrenetic distance is that of the shortest path between two languages. A further type is the reticular network which shows incompatibilities (due to for example to contact) as reticulations and its internal nodes do represent ancestors. A network may also be constructed by adding contact edges to a tree.
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All of these sinuses drain into the efferent lymphatic vessels to exit the node at the hilum on the concave side. These are channels within the node lined by endothelial cells along with fibroblastic reticular cells, allowing for the smooth flow of lymph. The endothelium of the subcapsular sinus is continuous with that of the afferent lymph vessel and also with that of the similar sinuses flanking the trabeculae and within the cortex. These vessels are smaller and don't allow the passage of macrophages so that they remain contained to function within a lymph node.
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This makes sense concerning their connections, as it would require a nucleus that receives and projects to the cerebellum to mediate that kind of complex circuitry. Furthermore, in terms of behavior, one does not think about saccadic movements when scanning a room, as the saccadic movements are not directly controlled by the cortex. The pontine nuclei are the most traditionally studied mostly because it is easy to see which nuclei degrade when the cerebellum is amputated. The neurons of the lateral reticular formation are very important for reflexes and the mediation of posture.
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The Madrid Metropolitan Plan (Spanish: Plan Regional de Estrategia Territorial) is a regional development plan. It was approved on March 1, 1996 and backed with initial parliamentary approval in 1997. It was enforced until 2001, when the new planning law (Ley del Suelo) required final approval from the Madrid Assembly in order to be enforced.Madrid Community Formal Approval (Spanish) Madrid Reticular Matrix Plan The Madrid Plan was indicative in nature and was a framework for decision-making in regional planning terms for the Community of Madrid (Comunidad de Madrid).
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They first saw a non compact tissue which should be submucosa using a technology called endomicroscopy. They hypothesised that the submucosa was not compact as it was previously seen on histological analysis but form a reticular pattern. To confirm their findings, they performed fixed samples of bile duct into a freezing media in order to conserve the shape of the submucosa. They then performed a histological analysis and with several staining technics, they described the submucosa as a network of collagenous bands separating open, formerly fluid-filled spaces.
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Spinal flexion leads to nuchal rigidity, or stiff neck, due to the stretching of the inflamed meninges. The increase in intracranial pressure stimulates the area postrema to create nausea sensations which may lead to brain herniation and damage to the reticular formation. Ultimately, the increase in cerebrospinal fluid from inflammation of the meninges increases intracranial pressure and leads to the destruction of the central nervous system. Although it is unknown of the exact pathophysiology behind the seizures caused by PAM, scientists speculate the seizures arise from altered meningeal permeability caused by increased intracranial pressure.
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The dark tone at the head is marked with yellow dots above the mouth, and the yellowish cream background colour of the underside displays a blackish reticular pattern. The largest specimens are those found at Kangaroo Island, near the coast of South Australia, these are also darker than those on the mainland and possess a greater number of scale rows at the ventral side. Fat layers in V. rosenbergi constitute around 7.6% of body weight, allowing energy reserves to be stored throughout the body and tail. This monitor can reach a length of 1.5 metres.
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Evidence for low-threshold calcium current was first described in neurons of the inferior olivary nucleus (1981). This nucleus generates synchronous rhythmic activity, which under certain conditions is manifested as a tremor. Low-threshold calcium spikes have been described in neurons from a variety of brain nuclei, including the thalamic relay, medial pontine reticular formation, lateral habenula, septum, deep cerebellar nuclei, CA1-CA3 of the hippocampus, association cortex, paraventricular and preoptic nuclei of the hypothalamus, dorsal raphe, globus pallidus, striatum, and subthalamic nucleus. Thalamic relay cells show two types of responses.
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At the midpoint of an oscillation the hair bundles resume their resting position. When the basilar membrane moves downward, the hair bundles are driven in the inhibitory direction. Basilar Membrane motion causes a shearing motion between the reticular lamina and the tectorial membrane, thereby activating the mechano-sensory apparatus of the hair bundle, which in turn generates a receptor potential in the hair cells. Thus the sound pressure wave is transduced to an electrical signal which can be processed as sound in higher parts of the auditory system.
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Mebicar (or tetramethylglycoluril) is an anxiolytic medication produced by Latvian pharmaceutical company Olainfarm and sold in Latvia and Russia under the brand name Adaptol. Mebicar is not approved for use in the United States. Mebicar has an effect on the structure of limbic-reticular activity, particularly on hypothalamus emotional zone, as well as on all 4 basic neuromediator systems – γ aminobutyric acid (GABA), choline, serotonin and adrenergic activity. Mebicar decreases the brain noradrenaline level, exerts no effect on the dopaminergic systems, increases the brain serotonin level, and does not elicit cholinolytic action.
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Before any treatment of leg telangectasia (spider veins) is considered, it is essential to have duplex ultrasonography, the test that has replaced Doppler ultrasound. The reason for this is that there is a clear association between leg telangectasia (spider veins) and underlying venous reflux. Research has shown that 88 to 89% of women with telangectasia (spider veins) have refluxing reticular veins close, and 15% have incompetent perforator veins nearby. As such, it is essential to both find and treat underlying venous reflux before considering any treatment at all.
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Lymphoid tissue associated with the lymphatic system is concerned with immune functions in defending the body against infections and the spread of tumours. It consists of connective tissue formed of reticular fibers, with various types of leukocytes (white blood cells), mostly lymphocytes enmeshed in it, through which the lymph passes. Regions of the lymphoid tissue that are densely packed with lymphocytes are known as lymphoid follicles. Lymphoid tissue can either be structurally well organized as lymph nodes or may consist of loosely organized lymphoid follicles known as the mucosa-associated lymphoid tissue (MALT).
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The first mechanism has to do with cortical centers responsible for visual processing. Irritation of visual association cortices (Brodmann's areas 18 and 19) cause complex visual hallucinations. The second mechanism is deafferentation, the interruption or destruction of the afferent connections of nerve cells, of the visual system, caused by lesions, leading to the removal of normal inhibitory processes on cortical input to visual association areas, leading to complex hallucinations as a release phenomenon. The third mechanism has to do with the reticular activating system, which plays a role in the maintenance of arousal.
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The RM separates endolymph in the cochlear duct from underlying corticolymph and perilymph of the scala tympani. The hair processes of the outer hair cells emerge through and above the RM, thus immobilizing the apical pole of the outer hair cells. At the opposite basilar pole, the outer hair cells are firmly held by the phalangeal cells. The inner phalangeal cells that surround the inner hair cells reach the surface of the organ of corti, but, even their inner-most row, are not included in the reticular membrane.
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Hans Eysenck described extraversion-introversion as the degree to which a person is outgoing and interactive with other people. These behavioral differences are presumed to be the result of underlying differences in brain physiology. Eysenck associated cortical inhibition and excitation with the ascending reticular activation system (ARAS), a pathway located in the brainstem. Extraverts seek excitement and social activity in an effort to raise their naturally low arousal level, whereas introverts tend to avoid social situations in an effort to avoid raising their naturally high arousal level too far.
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The only spike of Influenza C virus, the hemagglutinin‐esterase‐fusion glycoprotein (HEF) combines receptor binding, receptor hydrolysis and membrane fusion activities. Like other hemagglutinating glycoproteins of influenza viruses HEF is S‐acylated, but only with stearic acid at a single cysteine located at the cytosol‐facing end of the transmembrane region. This HE protein however, has spikes in its structural organization as well. HEF trimers on the surfaces of both spherical and filamentous particles are arranged in a reticular structure that has been described to consist mainly of hexagons.
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These blocks were built into a reticular system, composed by austere buildings in clear rationalist style, such as the impressive Hotel Principi di Piemonte and the former Hotel Nazionale in Piazza CLN. Porches are built in a continuous entablature and marked with double columns, to be consistent with those of Piazza San Carlo. The section of the street between Piazza San Carlo and Piazza Castello was built in eclectic style, with arcades characterised by Serliana-type arches. To this day Via Roma is the street featuring the most fashionable boutiques of the city.
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It is evident that its expression depends on neural paths arising in close association with the telencephalic and diencephalic centers concerned with respiration. Wilson considered the mechanism to be in the region of the mesial thalamus, hypothalamus, and subthalamus. Kelly and co-workers, in turn, postulated that the tegmentum near the periaqueductal grey contains the integrating mechanism for emotional expression. Thus, supranuclear pathways, including those from the limbic system that Papez hypothesised to mediate emotional expressions such as laughter, probably come into synaptic relation in the reticular core of the brain stem.
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But when environmental conditions are favorable and the female is in estrus, the estrogen hormone, estradiol, induces sexual receptivity by the neurons in the ventromedial nucleus, the periaqueductal gray, and other areas of the brain. The ventromedial hypothalamus sends impulses down axons synapsing with neurons in the periaqueductal gray. These convey an impulse to neurons in the medullary reticular formation which project down the reticulospinal tract and synapse with the neurobiological circuits of the lordosis reflex in the spinal cord (L1–L6). These neurobiological processes induced by estradiol enable the tactile stimuli to trigger lordosis.
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Sneezing is also triggered by sinus nerve stimulation caused by nasal congestion and allergies. The neural regions involved in the sneeze reflex are located in the brainstem along the ventromedial part of the spinal trigeminal nucleus and the adjacent pontine- medullary lateral reticular formation. This region appears to control the epipharyngeal, intrinsic laryngeal and respiratory muscles, and the combined activity of these muscles serve as the basis for the generation of a sneeze. The sneeze reflex involves contraction of a number of different muscles and muscle groups throughout the body, typically including the eyelids.
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There was also a limited number of dyes and fixatives available prior to the middle of the 19th century. A landmark development came from Camillo Golgi who invented a silver staining technique in 1873 which he called la reazione nera (black reaction), but more popularly known as Golgi stain or Golgi method, in his honour. Using this technique nerve cells with their highly branched dendrites and axon could be clearly visualised against a yellow background. Unfortunately Golgi described the nervous system as a continuous single network, in support of a notion called reticular theory.
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In immunology, the mononuclear phagocyte system or mononuclear phagocytic system (MPS) also known as the reticuloendothelial system or macrophage system is a part of the immune system that consists of the phagocytic cells located in reticular connective tissue. The cells are primarily monocytes and macrophages, and they accumulate in lymph nodes and the spleen. The Kupffer cells of the liver and tissue histiocytes are also part of the MPS. The mononuclear phagocyte system and the monocyte macrophage system refer to two different entities, often mistakenly understood as one.
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They also possess an identifiable thymus and a well-developed spleen (their most important immune organ) where various lymphocytes, plasma cells and macrophages develop and are stored. Chondrostean fish (sturgeons, paddlefish and bichirs) possess a major site for the production of granulocytes within a mass that is associated with the meninges, the membranes surrounding the central nervous system. Their heart is frequently covered with tissue that contains lymphocytes, reticular cells and a small number of macrophages. The chondrostean kidney is an important hemopoietic organ; it is where erythrocytes, granulocytes, lymphocytes and macrophages develop.
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Reticular Synthesis of MOFs is a term that has been recently coined to describe the bottom-up method of assembling cautiously designed rigid molecular building blocks into prearranged structures held together by strong chemical bonds. The synthesis of two-dimensional MOFs begins with the knowledge of a target "blueprint" or a network, followed by identification of the required building blocks for its assembly. By interchanging metal centers and organic ligands, one can fine-tune electronic and magnetic properties observed in MOFs. There have been recent efforts synthesize conductive MOFs using triyphenylene linkers.
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Visual input from the optic tract is processed by the lateral geniculate nucleus of the thalamus, auditory input in the medial geniculate nucleus, and somatosensory input in the ventral posterior nucleus of the thalamus. Thalamic nuclei project to cortical areas of distinct architectural organization and relay the processed information back to the area of original activity in the thalamus via corticothalamic (CT) fibers. The thalamic reticular nucleus (TRN) receives incoming signals via corticothalamic pathways and regulates activity within the thalamus accordingly. Cortico-thalamic feedback neurons are mostly found in layer VI of the cortex.
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The I1 receptor appears to be a G protein-coupled receptor that is localized on the plasma membrane. It may be coupled to PLA2 signalling and thus prostaglandin synthesis. In addition, activation inhibits the sodium- hydrogen antiporter and enzymes of catecholamine synthesis are induced, suggesting that the I1 receptor may belong to the neurocytokine receptor family, since its signaling pathways are similar to those of interleukins. It is found in the neurons of the reticular formation, the dorsomedial medulla oblongata, adrenal medulla, renal epithelium, pancreatic islets, platelets, and the prostate.
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An animal study in rabbits demonstrated that estazolam induces a drowsy pattern of spontaneous EEG including high voltage slow waves and spindle bursts increase in the cortex and amygdala, while the hippocampal theta rhythm is desynchronized. Also low voltage fast waves occur particularly in the cortical EEG. The EEG arousal response to auditory stimulation and to electric stimulation of the mesencephalic reticular formation, posterior hypothalamus and centromedian thalamus is significantly suppressed. The photic driving response elicited by a flash light in the visual cortex is significantly suppressed by estazolam.
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In particular, in the region of the brain a large number of fine filaments called arachnoid trabeculae pass from the arachnoid through the subarachnoid space to blend with the tissue of the pia mater. The arachnoid barrier has no extracellular collagen and is considered to represent an effective morphological and physiological meningeal barrier between the cerebrospinal fluid and subarachnoid space and the blood circulation in the dura. The arachnoid barrier layer is characterized by a distinct continuous basal lamina on its inner surface toward the innermost collagenous portion of the arachnoid reticular layer.
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These fibers provide very powerful, excitatory input to the cerebellum which results in the generation of complex spike excitatory postsynaptic potential (EPSP) in Purkinje cells. In this way climbing fibers (CFs) perform a central role in motor behaviors. The climbing fibers carry information from various sources such as the spinal cord, vestibular system, red nucleus, superior colliculus, reticular formation and sensory and motor cortices. Climbing fiber activation is thought to serve as a motor error signal sent to the cerebellum, and is an important signal for motor timing.
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A repeated burst of action potentials occurs at lower frequencies in the 4–10 Hz range. These bursts can be sustained by inhibition from the thalamic reticular nucleus and may cause an activation of cortical regions that are normally inhibited by gamma-band activity during resonance column formation. While the effect of the deviation from normal patterns of gamma oscillatory activity during conscious perception is not entirely settled, it is proposed that the phenomenon can be used to explain chronic pain in cases where there is no specific peripheral nerve damage.
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In fact, when herniation is visible on a CT scan, the prognosis for a meaningful recovery of neurological function is poor. The patient may become paralyzed on the same side as the lesion causing the pressure, or damage to parts of the brain caused by herniation may cause paralysis on the side opposite the lesion. Damage to the midbrain, which contains the reticular activating network which regulates consciousness, will result in coma. Damage to the cardio-respiratory centers in the medulla oblongata will cause respiratory arrest and (secondarily) cardiac arrest.
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Past this period CD3 blocks the TCR- antigen binding and causes conformational change or the removal of the entire TCR3/CD3 complex from the T-cell surface. This lowers the number of available T-cells, perhaps by sensitizing them for the uptake by the epithelial reticular cells. The cross-binding of CD3 molecules as well activates an intracellular signal causing the T cell anergy or apoptosis, unless the cells receive another signal through a co-stimulatory molecule. CD3 antibodies shift the balance from Th1 to Th2 cells as CD3 stimulates Th1 activation.
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Effect upon the EEG of acute injury to the brain stem activating system. EEG Clin Neurophysiol 1949;1:475–8627 as illuminated by pathological studies in humans.Parvizi J, Damasio AR. Neuroanatomical correlates of brainstem coma. Brain 2003;126:1524–36 The current neurological consensus is that the arousal of consciousness depends upon reticular components which reside in the midbrain, diencephalon and pons.Textbook of clinical neurology, 2nd Edn. Ed. Goetz CG. Elsevier Science, 2003Bleck TP. In Textbook of clinical neurology, 3rd Edn. Ed. Goetz CG. Elsevier Science, 2007 It is said that the midbrain reticular formation may be viewed as a driving centre for the higher structures, loss of which produces a state in which the cortex appears, on the basis of electroencephalographic (EEG) studies, to be awaiting the command or ability to function. The role of diencephalic (higher brain) involvement is stated to be uncertain and we are reminded that the arousal system is best regarded as a physiological rather than a precise anatomical entity. There should, perhaps, also be a caveat about possible arousal mechanisms involving the first and second cranial nerves (serving sight and smell) which are not tested when diagnosing brainstem death but which were described in cats in 1935 and 1938.
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Bust of Santiago Ramón y Cajal in Burgos, 2014. Ramón y Cajal received many prizes, distinctions, and societal memberships during his scientific career, including honorary doctorates in medicine from Cambridge University and Würzburg University and an honorary doctorate in philosophy from Clark University. The most famous distinction he was awarded was the Nobel Prize in Physiology or Medicine in 1906, together with the Italian scientist Camillo Golgi "in recognition of their work on the structure of the nervous system". This caused some controversy because Golgi, a staunch supporter of reticular theory, disagreed with Ramón y Cajal in his view of the neuron doctrine.
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For instance, communication between an activated amygdala and the lateral hypothalamus results in increased blood pressure and dilation of the pupils; the initiation of the central grey via communication from the amygdala results in the organism's becoming frozen in its tracks; communication between the activated amygdala and the paraventricular nucleus of the hypothalamus releases hormones associated with stress. Literature has linked the FPS response to interplay between the central nucleus of the amygdala and both the central grey and nucleus reticular pontis caudalis. Insult (e.g., traumatic brain injury) to these brain areas inhibits any display of FPS response in humans.
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The somatic motor is the OHC cell body and its ability to elongate or contract longitudinally due to changes in membrane potential. This function is aptly associated with the OHC structure within the organ of Corti. As seen through scanning electron micrograph imagery, the apical side of the OHC is mechanically coupled to the reticular lamina while the basal side of the OHC is coupled to the Deiter's cell cupula. Because the cell body is not in direct contact with any structure and is surrounded by the fluid-like perilymph, the OHC is considered dynamic and able to support electromotility.
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Cerebellar vermis has three main parts: vestibulocerebellum (eye movements regulated by the integration of visual info provided by the superior colliculus and balance info), spinocerebellum [integrates visual, auditory, proprioceptive, and balance info to act out body and limb movements. Trigeminal and dorsal column (of spinal cord) proprioceptive input, midbrain, thalamus, reticular formation and vestibular nuclei (medulla) outputs], and cerebrocerebellum (plans, times, and initiates movement after evaluating sensory input from, primarily, motor cortex areas, via pons and cerebellar dentate nucleus. It outputs to thalamus, motor cortex areas, and red nucleus).Chen, S.H. Annabel, and John E. Desmond.
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In the adult rat central nervous system (CNS), plexin A4 was present in neurons and fibers throughout the brain and spinal cord, including neocortex, hippocampus, lateral hypothalamus, red nucleus, facial nucleus, and the mesencephalic trigeminal nucleus. Fibers expressed Plexin A4 in the lateral septum, nucleus accumbens, several thalamic nuclei, substantia nigra pars reticulata, zona incerta, pontine reticular formation, as well as in several cranial nerve nuclei. Plexin A4 has been found in dorsal and, to a greater extent, ventral horns of the spinal cord. Both motor neurons and interneurons in the ventral horn express Plexin A4.
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It receives information from the caudal solitary tract and transmits signals mainly to the medial hypothalamus but also to the lateral hypothalamus and many of the nuclei targeted by the medial parabrachial nucleus. The subparabrachial nucleus, also known as the Kölliker-Fuse nucleus and diffuse reticular nucleus, is one of the three parabrachial nuclei between the midbrain and the pons. The subparabrachial nucleus regulates the breathing rate. It receives signals from the caudal, cardio-respiratory part of the solitary nucleus and sends signals to the lower medulla oblongata, the spinal cord, the amygdala and the lateral hypothalamus.
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Peripheral neuropathy should also be considered as a principal rule-out in young chickens with paralysis and nerve enlargement without visceral tumors, especially in nerves with interneuronal edema and infiltration of plasma cells. The presence of nodules on the internal organs may also suggest Marek's disease, but further testing is required for confirmation. This is done through histological demonstration of lymphomatous infiltration into the affected tissue. A range of leukocytes can be involved, including lymphocytic cell lines such as large lymphocyte, lymphoblast, primitive reticular cells, and occasional plasma cells, as well as macrophage and plasma cells.
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Brodmann area 8 The frontal eye fields (FEF) are a region located in the frontal cortex, more specifically in Brodmann area 8 or BA8, of the primate brain. In humans, it can be more accurately said to lie in a region around the intersection of the middle frontal gyrus with the precentral gyrus, consisting of a frontal and parietal portion. The FEF is responsible for saccadic eye movements for the purpose of visual field perception and awareness, as well as for voluntary eye movement. The FEF communicates with extraocular muscles indirectly via the paramedian pontine reticular formation.
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Injury to either or both of the cerebral cortex or the reticular activating system (RAS) is sufficient to cause a person to enter coma. The cerebral cortex is the outer layer of neural tissue of the cerebrum of the brain. The cerebral cortex is composed of gray matter which consists of the nuclei of neurons, whereas the inner portion of the cerebrum is composed of white matter and is composed of the axons of neuron. White matter is responsible for perception, relay of the sensory input via the thalamic pathway, and many other neurological functions, including complex thinking.
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The Oculocardiac reflex, also known as Aschner phenomenon, Aschner reflex, or Aschner–Dagnini reflex, is a decrease in pulse rate associated with traction applied to extraocular muscles and/or compression of the eyeball. The reflex is mediated by nerve connections between the ophthalmic branch of the trigeminal cranial nerve via the ciliary ganglion, and the vagus nerve of the parasympathetic nervous system. Nerve fibres from the maxillary and mandibular divisions of the trigeminal nerve have also been documented. These afferents synapse with the visceral motor nucleus of the vagus nerve, located in the reticular formation of the brain stem.
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The main bulk of the tegmentum contains a complex synaptic network of neurons, primarily involved in homeostasis and reflex actions. It includes portions of the reticular formation. A number of distinct nerve tracts between other parts of the brain pass through it. The medial lemniscus – a narrow ribbon of fibres – passes through in a relatively constant axial position; at the level of the inferior colliculus it is near the lateral edge, on the ventral side, and retains a similar position rostrally (due to widening of the tegmentum towards the rostral end, the position can appears more medial).
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The interposed nucleus is smaller than the dentate nucleus but larger than the fastigial nucleus and functions to modulate muscle stretch reflexes of distal musculature. It is located dorsal to the fourth ventricle and lateral to the fastigial nucleus; it receives afferent neuronal supply from the anterior lobe of the cerebellum and sends output via the superior cerebellar peduncle and the red nucleus. The fastigial nucleus is the most medial efferent cerebellar nucleus, targeting the pontine and medullary reticular formation as well as the vestibular nuclei. This region deals with antigravity muscle groups and other synergies involved with standing and walking.
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The ascending reticular activating system consists of a set of neural subsystems that project from various thalamic nuclei and a number of dopaminergic, noradrenergic, serotonergic, histaminergic, cholinergic, and glutamatergic brain nuclei. When awake, it receives all kinds of non-specific sensory information and relays them to the cortex. It also modulates fight or flight responses and is hence linked to the motor system. During sleep onset, it acts via two pathways: a cholinergic pathway that projects to the cortex via the thalamus and a set of monoaminergic pathways that projects to the cortex via the hypothalamus.
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Cell membrane details between extracellular and intracellular fluid Sodium-potassium pump and the diffusion between extracellular fluid and intracellular fluid The extracellular fluid provides the medium for the exchange of substances between the ECF and the cells, and this can take place through dissolving, mixing and transporting in the fluid medium. Substances in the ECF include dissolved gases, nutrients, and electrolytes, all needed to maintain life. The ECF also contains materials secreted from cells in soluble form, but which quickly coalesces into fibres (e.g. collagen, reticular, and elastic fibres) or precipitates out into a solid or semisolid form (e.g.
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Superficial fascia is the lowermost layer of the skin in nearly all of the regions of the body, that blends with the reticular dermis layer. It is present on the face, over the upper portion of the sternocleidomastoid, at the nape of the neck, and overlying the breastbone. It consists mainly of loose areolar, and fatty adipose connective tissue and is the layer that primarily determines the shape of a body. In addition to its subcutaneous presence, superficial fascia surrounds organs and glands, neurovascular bundles, and is found at many other locations where it fills otherwise unoccupied space.
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On 17October, six feline finalists were selected as candidates for the flight, and a tuxedo cat with the designation C341 was chosen for the flight on launch day, along with a backup. Weighing in at , C341 was selected as the best of the six finalists due to her calm demeanor and appropriate weight. Electrodes were attached to her forward left and right rear leg to monitor cardiac activity. Nine electrodes had previously been implanted on her skull: two in the front sinus, one in the somatic area, two in the ventral hippocampal, two in the reticular area, and two in the association cortex.
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These genetic factors may contribute to spike-and- wave oscillations by decreasing the action potential threshold in reticular cells, making them more excitable and potentially easier to initiate synchronized firing. Another study has shown that these medium oscillations have led to spike-and-wave discharges. The activity of the primary and secondary cortical regions, as well as the adjacent insular cortex were recorded using an EEG and where applied with electrical stimulation. The findings here showed that the onset of spike-and-wave discharged were followed by 5–9 Hz oscillations in these cortical regions as well.
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A gap junction located in neurons is often referred to as an electrical synapse. The electrical synapse was discovered using electrical measurements before the gap junction structure was described. Electrical synapses are present throughout the central nervous system and have been studied specifically in the neocortex, hippocampus, vestibular nucleus, thalamic reticular nucleus, locus coeruleus, inferior olivary nucleus, mesencephalic nucleus of the trigeminal nerve, ventral tegmental area, olfactory bulb, retina and spinal cord of vertebrates. There has been some observation of weak neuron to glial cell coupling in the locus coeruleus, and in the cerebellum between Purkinje neurons and Bergmann glial cells.
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The anatomy of the flocculus shows that it is composed of two disjointed lobes or halves. The “halves” of the flocculus refer to the caudal half and the rostral half, and they indicate from where fiber projections are received and the path in which a signal travels. The caudal half of the flocculus receives mossy fiber projections mainly from the vestibular system and tegmental pontine reticular nucleus, an area within the floor of the midbrain that affects the axonal projections or images received by the cerebellum. Vestibular inputs are also carried through climbing fibers that project into the flocculus, stimulating Purkinje cells.
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Although Golgi's earlier works between 1873 and 1885 clearly depicted the axonal connections of cerebellar cortex and olfactory bulb as independent of one another, his later works including the Nobel Lecture showed the entire granular layer of the cerebellar cortex occupied by a network of branching and anastomosing nerve processes. This was due to his strong conviction in the reticular theory. Golgi's theory was challenged by Ramón y Cajal, who used the same technique developed by Golgi. According to Ramón y Cajal's neurone theory, the nervous system is but a collection of individual cells, the neurones, which are interconnected to form a network.
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The OLF family is found in the endoplasmic reticular membranes of eukaryotes. N-linked glycosylation in eukaryotic cells follows a conserved pathway in which a tetradecasaccharide substrate (Glc3Man9GlcNAc2) is initially assembled in the ER membrane as a dolichylpyrophosphate (Dol- PP)-linked intermediate before being transferred to an asparaginyl residue in a lumenal protein. An intermediate, Man5GlcNAc2-PP-Dol is made on the cytoplasmic side of the membrane and translocated across the membrane so that the oligosaccharide chain faces the ER lumen where biosynthesis continues to completion. The flippase that catalyzes the translocation step is dependent on the Rft1 protein (TC# 2.A.66.3.
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In 1863 a German anatomist Otto Friedrich Karl Deiters described the existence of an unbranched tubular process (the axon) extending from some cells in the central nervous system, specifically from the lateral vestibular nucleus. In 1871 Gerlach proposed that the brain is composed of "protoplasmic network", hence the basis of reticular theory. According to Gerlach, the nervous system simply consisted of a single continuous network called the reticulum. In 1873 Golgi invented a revolutionary method for microscopic research based on a specific technique for staining nerve cells, which he called "la reazione nera" (the "black reaction").
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The branchial motor component of CN IX provides voluntary control of the stylopharyngeus muscle, which elevates the pharynx during swallowing and speech. Origin and central course The branchial motor component originates from the nucleus ambiguus in the reticular formation of the medulla Rostral medulla. Fibers leaving the nucleus ambiguus travel anteriorly and laterally to exit the medulla, along with the other components of CN IX, between the olive and the inferior cerebellar peduncle. Intracranial course Upon emerging from the lateral aspect of the medulla the branchial motor component joins the other components of CN IX to exit the skull via the jugular foramen.
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Cats with mesencephalic interruptions to the ARAS entered into a deep sleep and displayed corresponding brain waves. In alternative fashion, cats with similarly placed interruptions to ascending auditory and somatic pathways exhibited normal sleeping and wakefulness, and could be awakened with physical stimuli. Because these external stimuli would be blocked on their way to the cortex by the interruptions, this indicated that the ascending transmission must travel through the newly discovered ARAS. Finally, Magoun recorded potentials within the medial portion of the brain stem and discovered that auditory stimuli directly fired portions of the reticular activating system.
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Various molecular, genetic and imaging studies have been conducted as for the localization of the CPGs. The results have shown that the networks responsible for locomotion are distributed throughout the lower thoracic and lumbar regions of the spinal cord. Rhythmic movements of the tongue, that participate in swallowing, mastication and respiration, are driven by hypoglossal nuclei, which receive inputs from the dorsal medullary reticular column (DMRC) and the nucleus of the tractus solitarius (NTS). The hypoglossal nucleus receives rhythmic excitatory inputs also from brainstem respiratory neurons within the pre-Boetzinger complex, which appears to play an important role in the origin of respiration rhythmogenesis.
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Individuals with GATA2 deficiency commonly exhibit abnormalities in their circulating blood cells (see above "Hematologic" section of Signs and symptoms) that may precede other signs and symptoms of the disease by years. Their bone marrow typically shows significant reductions in one or more types of blood cell lines (i.e. hypocellularity) with characteristic dysplastic features of increased sizes of cells in the red blood cell line (i.e. macrocytic erythropoiesis), small or enlarged megakaryocytes, abnormalities in the maturation of cells in the granulocyte cell line, fibrosis consisting of reticular fibers, increased numbers of T cells containing numerous large granules in their cytoplasm, and in advanced cases increases in blast cell numbers.
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Neurons are more susceptible to brain ischemia than the supporting glial cells, because neurons have higher energy demand, conduct an action potential, and produce glutamate, whereas glial cells lack those properties. Yet neurons differ among themselves in their sensitivity to ischemia, depending on the specific properties they exhibit, relating to their locations in the brain. Selective vulnerability is how some parts of the brain are more sensitive to anoxia than others, and thus to ischemic insult. Anoxia-prone cells in the brain include the hippocampal pyramidal cells of CA1, cerebellar purkinje cells, pyramidal neocortical neurons in some layers, basal ganglia, reticular neurons of the thalamus, and brainstem neurons.
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When a US is delivered to the cornea of the eye, sensory information is carried to the trigeminal nucleus and relayed both directly and indirectly (via reticular formation) to the accessory abducens and abducens motor nuclei (see Cranial nerve nucleus). Output from these nuclei control various eye muscles that work synergistically to produce an unconditioned blink response to corneal stimulation (reviewed, Christian & Thompson, 2003). Electromyogram (EMG) activity of the orbicularis oculi muscle, which controls eyelid closure, is considered to be the most prominent and sensitive component of blinking (Lavond et al., 1990) and is, thus, the most common behaviorally-derived dependent variable in studies of EBC.
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Scheme showing anatomical location of lesions in one and a half syndrome. The syndrome usually results from single unilateral lesion of the paramedian pontine reticular formation and the ipsilateral medial longitudinal fasciculus. An alternative anatomical cause is a lesion of the abducens nucleus (VI) on one side (resulting in a failure of abduction of the ipsilateral eye and adduction of the contralateral eye = conjugate gaze palsy towards affected side), with interruption of the ipsilateral medial longitudinal fasciculus after it has crossed the midline from its site of origin in the contralateral abducens (VI) nucleus (resulting in a failure of adduction of the ipsilateral eye).
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In line with the features described by Berg (1955) to be the significant diagnostic characters of Tristichopteridae, Eusthenodon possesses proportionately large, distinctively round scales without cosmine that exhibit a reticular pattern of ridges with rare appearance of independent tubercles. Furthermore, each of these round cosmineless scales include a proximal central attachment boss, also diagnostic of Tristichopteridae. In contrast to most other tristichopterids, the ornamentation of Eusthenodon scales exhibit ridges forming distinct networks whereas scales from Eusthenopteron tend to have an ornamentation of considerably shorter ridges present in the incompletely fused tubercles. The area of overlap between scales in Eusthenodon is also larger than the scales of Eusthenopteron.
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Damage to any of the physiology described above can disrupt Listing's law, and thus have negative impacts for vision. Disorders of the eye muscles (such as strabismus) often cause torsional offsets in eye position that are particularly troublesome when they differ between the two eyes, as the resulting cyclodisparity may lead to cyclodisplopia (double vision due to relative torsion) and may prevent binocular fusion. Damage to the vestibular system and brainstem reticular formation centres for 3-D eye control can cause torsional offsets and/or torsional drifting motion of the eyes that severely disrupts vision. Degeneration of the Cerebellum causes torsional control to become 'sloppy'.
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Structures of the brainstem, the origin of the arousal system, viewed along the sagittal plane Wakefulness is regulated by the ascending reticular activating system, which is composed of five major neurotransmitter systems – the acetylcholine, norepinephrine, dopamine, histamine, and serotonin systems – that originate in the brainstem and form connections which extend throughout the cerebral cortex. When stimulated, these systems produce cortical activity and alertness. The noradrenergic system is a bundle of axons that originate in the locus coeruleus and ascends up into the neocortex, limbic system, and basal forebrain. Most of the neurons are projected to the posterior cortex which is important with sensory information, and alertness.
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The exact mechanism for the induction of the sopite syndrome is still unknown; however, a leading theory asserts that the sopite syndrome (and perhaps motion sickness in general) is somehow related to the reticular formation, an area of the brainstem associated with arousal. A study of motion-induced effects on the P50 potential (a measure of arousal) showed that subjects exposed to motion environments experience decreased sensory gating, which involves the filtering of information in the brain.Dornhoffer, J. L., Mamiya, N., Bray, P., Skinner, R. D., & Garcia-Rill, E. (2002). Effects of rotation on the sleep state- dependent midlatency auditory evoked P50 potential in the human.
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In fact, neurons isolated from the reticular nucleus of the thalamus of the GAERS showed 55% greater T-type currents, and these currents were attributed to an increase in the Cav3.2 mRNA, according to Tally et al. suggesting that T-type protein expression was up regulated in the GAERS. Further experiments on the GAERS showed that, indeed, the expression of T-type calcium channels play a key role in seizures caused by absence epilepsy in the GAERS. Also, other evidence suggest that T-type calcium channel expression is not only up regulated in absence epilepsy, but also in other forms of epilepsy as well.
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Denervation of skeletal muscle tissue secondary to poliovirus infection can lead to paralysis. In around 1 percent of infections, poliovirus spreads along certain nerve fiber pathways, preferentially replicating in and destroying motor neurons within the spinal cord, brain stem, or motor cortex. This leads to the development of paralytic poliomyelitis, the various forms of which (spinal, bulbar, and bulbospinal) vary only with the amount of neuronal damage and inflammation that occurs, and the region of the CNS affected. The destruction of neuronal cells produces lesions within the spinal ganglia; these may also occur in the reticular formation, vestibular nuclei, cerebellar vermis, and deep cerebellar nuclei.
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Subsequent findings revealed CNH can also occur in conscious patients. Patients with tumor-induced CNH remain conscious because the reticular activating system of the brain is not affected by the tumor in the early stages of the condition. The condition is considered extremely uncommon, and only 21 additional cases of tumor-inducing CNH were reported up until 2005. Only five of these cases were reported in children. The causes associated with conscious CNH are more varied than originally predicted by Plum and Swanson’s study of comatose patients, although the most commonly reported causes of CNH involve infiltrative gliomas and lymphomas of the brainstem and pons.
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The superior salivatory nucleus (or nucleus salivatorius superior) of the facial nerve is a visceromotor cranial nerve nucleus located in the pontine tegmentum. It is one of the salivatory nuclei. Parasympathetic efferent fibers of the facial nerve (preganglionic fibers) arise according to some authors from the small cells of the facial nucleus, or according to others from a special nucleus of cells scattered in the reticular formation, dorso-medial to the facial nucleus – the superior salivatory nucleus. Some of the preganglionic fibers travel along the greater petrosal nerve through the pterygoid canal, where they join the postsynaptic fibers of the deep petrosal nerve to become the nerve of the pterygoid canal.
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Retrieved on 12 March 2018." Makoto Fujita and Omar Yaghi win Wolf Prize in Chemistry ", Chemical & Engineering News, 19 February 2018. Retrieved on 12 March 2018." Spiers Memorial Lecture - Progress and prospects of reticular chemistry ", Royal Society of Chemistry, 18 August 2017. Retrieved on 12 March 2018. His most recognizable work is in the design and production of new classes of compounds known as metal-organic frameworks (MOFs), zeolitic imidazolate frameworks (ZIFs)," Combinatorial Crystals ", Chemical & Engineering News, 18 February 2008. Retrieved on 12 March 2018. and covalent organic frameworks (COFs)." Porous Crystalline Organic Frameworks ", Chemical & Engineering News, 28 May 2007. Retrieved on 12 March 2018.
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MCH is a cyclic 19-amino acid neuropeptide, as it is a polypeptide chain that is able to act as a neurotransmitter. MCH neurons are mainly concentrated in the lateral hypothalamic area, zona incerta, and the incerto-hypothalamic area, but they are also located, in much smaller amounts, in the paramedian pontine reticular formation (PPRF), medial preoptic area, laterodorsal tegmental nucleus, and the olfactory tubercle. MCH is activated by binding to two G-coupled protein receptors (GCPRs), MCHR1 and MCHR2. MCHR2 has only been identified in certain species such as humans, dogs, ferrets, and rhesus monkeys, while other mammals such as rodents and rabbits do not have the receptor.
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Spinal cord tracts - reticulospinal tract labeled in red, near-center at left in figure The reticulospinal tracts, also known as the descending or anterior reticulospinal tracts, are extrapyramidal motor tracts that descend from the reticular formation in two tracts to act on the motor neurons supplying the trunk and proximal limb flexors and extensors. The reticulospinal tracts are involved mainly in locomotion and postural control, although they do have other functions as well. The descending reticulospinal tracts are one of four major cortical pathways to the spinal cord for musculoskeletal activity. The reticulospinal tracts works with the other three pathways to give a coordinated control of movement, including delicate manipulations.
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Actinic keratosis, atrophic form A lesion biopsy is performed if the diagnosis remains uncertain after a clinical physical exam, or if there is suspicion that the AK might have progressed to squamous cell carcinoma. The most common tissue sampling techniques include shave or punch biopsy. When only a portion of the lesion can be removed due to its size or location, the biopsy should sample tissue from the thickest area of the lesion, as SCCs are most likely to be detected in that area. If a shave biopsy is performed, it should extend through to the level of the dermis in order to provide sufficient tissue for diagnosis; ideally, it would extend to the mid- reticular dermis.
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It can also be defined as a score of ≤ 8 on the Glasgow Coma Scale (GCS) lasting ≥ 6 hours. For a patient to maintain consciousness, the components of wakefulness and awareness must be maintained. Wakefulness describes the quantitative degree of consciousness, whereas awareness relates to the qualitative aspects of the functions mediated by the cortex, including cognitive abilities such as attention, sensory perception, explicit memory, language, the execution of tasks, temporal and spatial orientation and reality judgment. From a neurological perspective, consciousness is maintained by the activation of the cerebral cortex—the gray matter that forms the outer layer of the brain and by the reticular activating system (RAS), a structure located within the brainstem.
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While basal ganglia, cerebellar purkinje cells, hippocampal, and neocortical cells are more vulnerable to transient ischemic attack (TIA), brainstem and thalamic reticular neurons are more vulnerable to prolonged ischemic attack (stroke proper). Meanwhile, the hippocampal pyramidal cells have been identified as the most vulnerable cells to ischemia. One possible explanation for why selective vulnerability exists attributes the phenomenon to the different amounts of glutamate produced by different neurons, since it is glutamate release to the synaptic cleft that triggers Ca2+ influx, which in turn triggers biochemical processes that damage the neurons. In other research, variation in the expression of immediate early gene and heat shock protein was identified as causing selective vulnerability.
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Microscopically, areas of "apparent fatty degeneration and/or necrosis, often with pooled fat from destroyed adipose cells (oil cysts) and with marrow fibrosis (reticular fatty degeneration)" are seen. These changes are present even if "most bony trabeculae appear at first glance viable, mature and otherwise normal, but closer inspection demonstrates focal loss of osteocytes and variable micro cracking (splitting along natural cleavage planes). The microscopic features are similar to those of ischaemic or aseptic osteonecrosis of long bones, corticosteroid-induced osteonecrosis, and the osteomyelitis of caisson (deep-sea diver's) disease". In the cancellous portion of femoral head it is not uncommon to find trabeculae with apparently intact osteocytes which seem to be "alive" but are no longer synthetizing collagen.
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They also possess an identifiable thymus and a well-developed spleen (their most important immune organ) where various lymphocytes, plasma cells and macrophages develop and are stored. Chondrostean fish (sturgeons, paddlefish and bichirs) possess a major site for the production of granulocytes within a mass that is associated with the meninges (membranes surrounding the central nervous system.) Their heart is frequently covered with tissue that contains lymphocytes, reticular cells and a small number of macrophages. The chondrostean kidney is an important hemopoietic organ; where erythrocytes, granulocytes, lymphocytes and macrophages develop. Like chondrostean fish, the major immune tissues of bony fish (or teleostei) include the kidney (especially the anterior kidney), which houses many different immune cells.
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In the ventral reticulum, less dense, larger digesta particles may be propelled up into the oesophagus and mouth during contractions of the reticulum. Digesta is chewed in the mouth in a process known as rumination, then expelled back down the oesophagus and deposited in the dorsal sac of the reticulum, to be lodged and mixed into the ruminal mat again. Denser, small particles stay in the ventral reticulum during reticular contraction, and then during the next contraction may be swept out of the reticulorumen with liquid through the reticulo-omasal orifice, which leads to the next chamber in the ruminant animal's alimentary canal, the omasum. Water and saliva enter through the rumen to form a liquid pool.
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The cochlea thus acts as an 'acoustic prism', distributing the energy of each Fourier component of a complex sound at different locations along its longitudinal axis. Hair cells in the cochlea are stimulated when the basilar membrane is driven up and down by differences in the fluid pressure between the scala vestibuli and scala tympani. Because this motion is accompanied by a shearing motion between the tectorial membrane and the reticular lamina of the organ of Corti, the hair bundles that link the two are deflected, which initiates mechano-electrical transduction. When the basilar membrane is driven upward, shear between the hair cells and the tectorial membrane deflects hair bundles in the excitatory direction, toward their tall edge.
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Abbreviations: ACC, anterior cingulate cortex; Am, nucleus ambiguus; Amyg, amygdala; AT, anterior thalamus; Av, nucleus avalanche; DLM, dorsolateral nucleus of the medial thalamus; DM, dorsal medial nucleus of the midbrain; HVC, high vocal center; LMAN, lateral magnocellular nucleus of the anterior nidopallium; LMC, laryngeal motor cortex; OFC, orbito-frontal cortex; PAG, periaqueductal gray; RA, robust nucleus of the arcopallium; RF, reticular formation; vPFC, ventral prefrontal cortex; VLT, ventro-lateral division of thalamus; XIIts, bird twelfth nerve nucleus. From Petkov, CI; Jarvis ED (2012). "Birds, primates, and spoken language origins: behavioral phenotypes and neurobiological substrates". Front. Evol. Neurosci. 4:12. Humans seem to have analogous anterior and posterior vocal pathways which are implicated in speech production and learning.
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The altered coat of the arterioles, consisting of adenoid tissue, presents here and there thickenings of a spheroidal shape, the white pulp. The arterioles end by opening freely into the splenic pulp; their walls become much attenuated, they lose their tubular character, and the endothelial cells become altered, presenting a branched appearance, and acquiring processes which are directly connected with the processes of the reticular cells of the pulp. In this manner the vessels end, and the blood flowing through them finds its way into the interstices of the reticulated tissue of the splenic pulp. Thus the blood passing through the spleen is brought into intimate relation with the elements of the pulp, and no doubt undergoes important changes.
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Historically, crystals were developed by experimentation, currently formalized as combinatorial chemistry, but one contemporary desideratum is the synthesis of materials designed in advance, and one proposal is to design crystals (the designs being crystal nets, perhaps represented as one unit cell of a crystal net) and then synthesize them from the design. This effort, in what Omar Yaghi described as reticular chemistry is proceeding on several fronts, from the theoretical to synthesizing highly porous crystals. One of the primary issues in annealing crystals is controlling the constituents, which can be difficult if the constituents are individual atoms, e.g., in zeolites, which are typically porous crystals primarily of silicon and oxygen and occasional impurities.
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There are conflicting hypotheses for the function of the many mGlu receptors with regards to epileptic seizures, however the role of the mGlu4 receptor is undisputed in the generation of SWDs, shown in animal models. In one study, knockout mice lacking mGlu4 receptors showed a disruption of glutamate and GABA release in the thalamocortical network and were resistant to absence seizures induced by low doses of pentylenetetrazole. Another study showed that bilateral injection of a mGlu4 receptor antagonist into the nRT (thalamic reticular nucleus) of normal mice protected against pentylenetetrazole induced seizures. Also, WAG/Rij rats show an increased expression of mGlu4 receptors in the nRT when compared to a control group of normal rats.
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Arousal is the physiological and psychological state of being awoken or of sense organs stimulated to a point of perception. It involves activation of the ascending reticular activating system (ARAS) in the brain, which mediates wakefulness, the autonomic nervous system, and the endocrine system, leading to increased heart rate and blood pressure and a condition of sensory alertness, mobility, and readiness to respond. Arousal is mediated by several neural systems. Wakefulness is regulated by the ARAS, which is composed of projections from five major neurotransmitter systems that originate in the brainstem and form connections extending throughout the cortex; activity within the ARAS is regulated by neurons that release the neurotransmitters acetylcholine, norepinephrine, dopamine, histamine, and serotonin.
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Gastric mucosa at low magnification (H&E; stain) Epithelial tissue is composed of closely packed cells, bound to each other by cell adhesion molecules, with little intercellular space. Epithelial cells can be squamous (flat), cuboidal or columnar and rest on a basal lamina, the upper layer of the basement membrane, the lower layer is the reticular lamina lying next to the connective tissue in the extracellular matrix secreted by the epithelial cells. There are many different types of epithelium, modified to suit a particular function. In the respiratory tract there is a type of ciliated epithelial lining; in the small intestine there are microvilli on the epithelial lining and in the large intestine there are intestinal villi.
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They also possess an identifiable thymus and a well-developed spleen (their most important immune organ) where various lymphocytes, plasma cells and macrophages develop and are stored. Chondrostean fish (sturgeons, paddlefish, and bichirs) possess a major site for the production of granulocytes within a mass that is associated with the meninges (membranes surrounding the central nervous system.) Their heart is frequently covered with tissue that contains lymphocytes, reticular cells and a small number of macrophages. The chondrostean kidney is an important hemopoietic organ; where erythrocytes, granulocytes, lymphocytes and macrophages develop. Like chondrostean fish, the major immune tissues of bony fish (or teleostei) include the kidney (especially the anterior kidney), which houses many different immune cells.
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Microscopically, the eggs differ from most other coccinellid eggs in that they have a more definite reticular pattern of sculpting on the chorion; in most Coccinellidae, the chorion is externally smooth. The larvae differ in appearance from those of other Coccinellidae in that they are covered with bands of spiny projections. A larva generally passes through five instars in a period of four to five weeks, after which it will anchor itself to a suitable surface, usually in a protected spot on the plant, where it changes its skin once more, forming a typical coccinellid pupa, from which it emerges as a beetle imago after several days. Many species have just one or perhaps two generations in a year.
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Large parts of the brain that are activated and sending signals during waking are inactive during NREM sleep and become reactivated during REM sleep. It is based on the fact that the brain and its neural circuitry is plastic and self- regulating, especially in its own activation and inactivation. This was observed by two experiments: development of sleepiness after dopamine neuron destruction in substantia nigra in the midbrain, and discovery of the reticular activating system, which are visual cues received through our eyes and to our brain that begin the waking process, that waking consciousness depends sleep. Following these studies, it became clear that activity levels and quality of consciousness were functions of brain activation and deactivation.
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Isolated lesions of the VI nerve nucleus will not give rise to an isolated VIth nerve palsy because paramedian pontine reticular formation fibers pass through the nucleus to the opposite IIIrd nerve nucleus. Thus, a nuclear lesion will give rise to an ipsilateral gaze palsy. In addition, fibers of the seventh cranial nerve wrap around the VIth nerve nucleus, and, if this is also affected, a VIth nerve palsy with ipsilateral facial palsy will result. In Millard-Gubler syndrome, a unilateral softening of the brain tissue arising from obstruction of the blood vessels of the pons involving sixth and seventh cranial nerves and the corticospinal tract, the VIth nerve palsy and ipsilateral facial paresis occur with a contralateral hemiparesis.
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Published in 1906, this was a compendium of ten of Sherrington's Silliman lectures, delivered at Yale University in 1904. The book discussed neuron theory, the "synapse" (a term he had introduced in 1897, the word itself suggested by classicist A. W. Verrall), communication between neurons, and a mechanism for the reflex-arc function. The work effectively resolved the debate between neuron and reticular theory in mammals, thereby shaping our understanding of the central nervous system. He theorized that the nervous system coordinates various parts of the body and that the reflexes are the simplest expressions of the interactive action of the nervous system, enabling the entire body to function toward a definite purpose.
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The membranous hypothallus is barely larger than the plasmodiocarp and dark brown to darkish. The peridium is double-layered: the outer layer, which occasionally features lime tubercles, is rough, gristly, wrinkled and shiny to faint, and the membranous inner layer is iridescent. The reticular, dense capillitium is composed of transparent strands, which connect the small, rotund to angular, light yellow to medium brown, occasionally whitish-coloured lime tubercles. The spores are in diameter 7 to 9 (rarely 6 to 10) µm and are nearly smooth to finely spiky and in the mass brown, individually pale purple or purple brown in transmitted light, occasionally groups of bigger, darker warts are found on them.
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The onion skin distribution differs from the dermatome distribution of the peripheral branches of the fifth nerve. Lesions which destroy lower areas of the spinal trigeminal nucleus (but spare higher areas) preserve pain-temperature sensation in the nose (V1), upper lip (V2) and mouth (V3) and remove pain- temperature sensation from the forehead (V1), cheeks (V2) and chin (V3). Although analgesia in this distribution is "nonphysiologic" in the traditional sense (because it crosses several dermatomes), this analgesia is found in humans after surgical sectioning of the spinal tract of the trigeminal nucleus. The spinal trigeminal nucleus sends pain-temperature information to the thalamus and sends information to the mesencephalon and the reticular formation of the brainstem.
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Mesenchymal stem cells within mesenchyme or the medullary cavity of a bone fracture initiate the process of intramembranous ossification. A mesenchymal stem cell, or MSC, is an unspecialized cell that can develop into an osteoblast. Before it begins to develop, the morphological characteristics of a MSC are: A small cell body with a few cell processes that are long and thin; a large, round nucleus with a prominent nucleolus that is surrounded by finely dispersed chromatin particles, giving the nucleus a clear appearance; and a small amount of Golgi apparatus, rough endoplasmic reticulum, mitochondria, and polyribosomes. Furthermore, the mesenchymal stem cells are widely dispersed within an extracellular matrix that is devoid of every type of collagen, except for a few reticular fibrils.
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It has previously been shown that repeated short trains of action potentials causes an exponential decay of the synaptic response amplitudes in the neurons of many neural networks, specifically the caudal pontine reticular nucleus (PnC). Recent research has suggested that only repeated burst stimulation, as opposed to single or paired pulse stimulation, at a very high frequency can result in SF. Some cells like aortic baroreceptor neurons could have devastating effects including the inability to regulate aortic blood pressure if the onset of synaptic fatigue were to affect them. Metabotropic glutamate autoreceptor activation in these neurons may inhibit synaptic transmission by inhibiting calcium influx, decreasing synaptic vesicle exocytosis and modulating the mechanisms governing synaptic vesicle recovery and endocytosis.Hay, M., Hoang, C. J., & Pamidimukkala, J. (2001).
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They are shrubs or small trees, which rarely reach a size of 4 m in height. The branches are purple brown when young, greyish brown when old, cylindrical, initially brown tomentose, glabrous in old age. Petiole 0.5-1.8 cm or almost absent, slightly brown or tomentose, subglabra; stipules deciduous, lanceolate, little brown tomentose, acuminate apex; ovate blade blade, oblong, rarely obovate, oblong- lanceolate, narrowly elliptical or elliptical-lanceolate, (2 -) 4-8 × 1.5-4 cm, coriaceous, abaxially prominent veins, abaxially visible reticular veins and visible or non-adaxially, back pale, glabrous or scarcely tomentose, shiny adaxially, glabrous, the apex obtuse, acute acuminate. The inflorescences in panicles or terminal of clusters, with many or few flowers; pedicels and peduncles rusty-tomentose; bracts and deciduous bracteoles.
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The eye muscles may also contribute to Listing's law by having position-dependent pulling directions during motion, i.e., this might be the mechanism that implements the 'half angle' rule described above. Higher gaze control centers in the frontal cortex and superior colliculus are only concerned with pointing gaze in the right direction and do not appear to be involved in 3-D eye control or the implementation of Listing's law. However the brainstem reticular formation centers that control vertical eye position (the interstitial nucleus of Cajal; INC) and saccade velocity (the rostral interstitial nucleus of the medial longitudinal fasciculus; riMLF) are equally involved in torsional control, each being divided into populations of neurons that control directions similar to those of the vertical and torsional pulling eye muscles.
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Most cases (80%) of squamous cell carcinoma attributed to ultraviolet radiation present in areas of the skin that are usually more exposed to sunlight (e.g., head, face, neck). Although a particular form of squamous cell carcinoma, Kangri cancer is more often associated with the abdomen, thigh, and leg regions due to the usage and positioning of kangri pots, which come in close contact with these anatomical features. Over time, the use of kangri pots to keep warm results in erythema ab igne, a precancerous keratotic growth that “take the shape of superficial, serpegenous, reticular blackish brown colored lesions.” Eventually, the cells at the lesion site become more irregular in shape and form; the lesions ulcerate and may become itchy and bloody.
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FLCN has been shown to interact through its C-terminus with two novel proteins, folliculin interacting protein 1 (FNIP1) and folliculin interacting protein 2 (FNIP2/FNIPL), and indirectly through FNIP1 and FNIP2 with AMP-activated protein kinase (AMPK). AMPK is an important energy sensor in cells and negative regulator of mechanistic target of rapamycin (mTOR) suggesting that FLCN and FNIP1 may play a role in modulating mTOR activity through energy or nutrient sensing pathways. Coimmunoprecipitation experiments with FNIP1 and FLCN expressed in HEK293 cells and in vitro binding assays have shown that the C-terminus of FLCN and amino acids 300 to 1166 of FNIP1 are required for optimal FLCN-FNIP1 binding. FLCN and FNIP1 colocalized to the cytoplasm in a reticular pattern.
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"Role of the Hippocampus, the Bed Nucleus of the Stria Terminalis, and the Amygdala in the Excitatory Effect of Corticotropin-Releasing Hormone on the Acoustic Startle Reflex". The Journal of Neuroscience, 1997, p. 6434 Activation of the BNST by certain hormones is thought to promote a startle responseLee, Younglim. "Role of the Hippocampus, the Bed Nucleus of the Stria Terminalis, and the Amygdala in the Excitatory Effect of Corticotropin-Releasing Hormone on the Acoustic Startle Reflex". The Journal of Neuroscience, 1997, p. 6434 The auditory pathway for this response was largely elucidated in rats in the 1980s. The basic pathway follows the auditory pathway from the ear up to the nucleus of the lateral lemniscus (LLN) from where it activates a motor centre in the reticular formation.
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Cleavage of ATN1 to an N terminal fragment relieves ATN1 of its nuclear export signal and concentrates it in the nucleus. Increased nuclear concentrations have been demonstrated via transfection assay to enhance cellular toxicity. In both the juvenile and adult forms, regions in which more than 40% of neurons became immunoreactive to 1C2 (a monoclonal antibody against expanded polyglutamine stretches) included: the nucleus basalis of Meynert, large striatal neurons, globus pallidus, subthalamic nucleus, thalamic intralaminar nucleus, lateral geniculate body, oculomotor nucleus, red nucleus, substantia nigra, trigeminal motor nucleus, nucleus raphes pontis, pontine nuclei, vestibular nucleus, inferior olive and the cerebellar dentate nucleus. The juvenile type also shows reactivity in the cerebral cortex, hippocampal CA1 area, and the reticular formation of the brainstem.
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The ascending MLF mainly arises from the superior and medial vestibular nucleus (VN) and is involved in the generation of the vestibulo-ocular reflex (VOR). This is achieved by inputs to the VN from: # the vestibulocochlear (8th cranial) nerve about head movements, # gait adjustments from the flocculus of the cerebellum, # head and neck proprioceptors and foot and ankle muscle spindle, via the fastigial nucleus. Descending fibers can also arise from the superior colliculus in the rostral midbrain for visual reflexes, the accessory occulomotor nuclei in the rostral midbrain for visual tracking, and the pontine reticular formation, which facilitates extensor muscle tone. Ascending tracts arise from the vestibular nucleus (VN) and terminate in the III, IV and VI nuclei, which are important for visual tracking.
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Primates are already developing the ability of three-dimensional vision, and humans have seen the most perfect vision, which is especially related to the high degree of development of the cerebral cortex, especially the associative optical cortex. The optical pathway is a system of interconnected neurons, which connect the retina to the subcortical and cortical visual centers. This time, the neurons accept and transmit the image of the observed object, enabling its understanding and spatial vision. Reflex neurons this time start from the reflex optical center (stratum griseum profundum colliculi superioris) and connect it with the motor nuclei of the spinal nerves (tractus tectospinalis), the motor nuclei of the cerebral nerves (tractus tectobulbaris), the reticular nuclei of the cerebral tract in the cerebral tract (tectocerebellar tract).
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Neurons there show activity levels that rise and fall with a period of about 24 hours, circadian rhythms: these activity fluctuations are driven by rhythmic changes in expression of a set of "clock genes". The SCN continues to keep time even if it is excised from the brain and placed in a dish of warm nutrient solution, but it ordinarily receives input from the optic nerves, through the retinohypothalamic tract (RHT), that allows daily light-dark cycles to calibrate the clock. The SCN projects to a set of areas in the hypothalamus, brainstem, and midbrain that are involved in implementing sleep-wake cycles. An important component of the system is the reticular formation, a group of neuron-clusters scattered diffusely through the core of the lower brain.
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The length of the shell attains 23 mm, its diameter 10 mm. (Original description) The small, thin, polished shell has a pointed simisigera protoconch of 3½ whorls and six subsequent whorls. The protoconch is bright yellow-brown, often caducous, leaving the white internal callus to represent it, which being molded on the interior of the protoconch whorls, is polished and smooth, while the original protoconch has an oblique reticular curved sculpture. The sculpture is much like that of Spergo glandiniformis, but having the whorls appressed at the suture lower on the antecedent whorl, the riblets more prominent, less oblique, and higher on the whorl, the fasciole more deeply impressed and its sculpture indicating a deeper sinus, and the fine spiral grooving continuous and uniform over the whole surface of the shell.
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Recent hypotheses have incorporated these ALC theories into the psychopathological study of schizophrenia, suggesting that each altered level of awareness is connected to a degree of suffering or shock experienced by the patient, arguably traversing the Qliphoth in the process. As the situation increases in seriousness, patients will descend to lower levels of consciousness and consequentially lose the capacity to cry, to smile, or to exhibit a wide range of emotions when reacting to the environment. In more physiologically based studies, scientists have found that while the reticular formation controls alertness, wakefulness, and arousal in the brain, many mental responses to internal and external stimuli are dictated through signals relayed to and from the thalamus. Propofol and other consciousness-altering drugs are therefore antagonists of thalamus activity, possibly leading to a drug-induced comatose state.
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The Madrid Metropolitan Plan was the first application, under the direction of Pedro B. Ortiz, of the CT method, approved administratively in 1996 and backed by the Madrid Regional Parliament in May 1997.Madrid Regional Parliament official publication (Spanish) The Plan was the physical continuation of a previously developed exercise of Strategic Urban Planning in 1989-1994 and established a framework for the future development of the Metropolis of Madrid. The numerous territorial decisions taken during the enforcement period until the new Planning Law of 2001 required revision and approval, have been determinant to the actual shape and efficiency of the metropolitan structure of Madrid. Under the plan, to respond to the rapid growth Madrid was experiencing (50% every 20 years), the Metropolitan Reticular Matrix Planning methodology was set in place.
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La Vila Olímpica del Poblenou or La Villa Olímpica (The Olympic Village of Poblenou) is a neighborhood in the Sant Martí district of Barcelona, Catalonia (Spain). It was constructed in the late 1980s and early 1990s for the 1992 Summer Olympic Games which took place in Barcelona. Its construction was devised by Oriol Bohigas, David Mackay and Albert Puigdomènec as a residential area in the otherwise industrial and working-class district of Poblenou, which underwent regeneration but involved massive expropriation, as well as the destruction of a sizeable portion of the district, including Industrial Revolution factories of architectural value such as Fàbrica Foret. It follows essentially the reticular outline of Eixample and Poblenou, with about 2000 new apartments in the area, owned by the mixed public-private company VOSA (Vila Olímpica Societat Anònima).
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Diagnosis can be established on clinical grounds and this may be enhanced with studies on surgically excised corneal tissue and in some cases with molecular genetic analyses. As clinical manifestations widely vary with the different entities, corneal dystrophies should be suspected when corneal transparency is lost or corneal opacities occur spontaneously, particularly in both corneas, and especially in the presence of a positive family history or in the offspring of consanguineous parents. Superficial corneal dystrophies - Meesmann dystrophy is characterized by distinct tiny bubble-like, punctate opacities that form in the central corneal epithelium and to a lesser extent in the peripheral cornea of both eyes during infancy that persists throughout life. Symmetrical reticular opacities form in the superficial central cornea of both eyes at about 4–5 years of age in Reis-Bücklers corneal dystrophy.
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In 1971, Ivan Illich envisioned 'learning webs' as a model for people to network the learning they needed: :I will use the words "opportunity web" for "network" to designate specific ways to provide access to each of four sets of resources. "Network" is often used, unfortunately, to designate the channels reserved to material selected by others for indoctrination, instruction, and entertainment. But it can also be used for the telephone or the postal service, which are primarily accessible to individuals who want to send messages to one another. I wish we had another word to designate such reticular structures for mutual access, a word less evocative of entrapment, less degraded by current usage and more suggestive of the fact that any such arrangement includes legal, organizational, and technical aspects.
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This stratified squamous epithelium is maintained by cell division within the stratum basale, in which differentiating cells slowly displace outwards through the stratum spinosum to the stratum corneum, where cells are continually shed from the surface. In normal skin, the rate of production equals the rate of loss; about two weeks are needed for a cell to migrate from the basal cell layer to the top of the granular cell layer, and an additional two weeks to cross the stratum corneum. The dermis is the layer of skin between the epidermis and subcutaneous tissue, and comprises two sections, the papillary dermis and the reticular dermis. The superficial papillary dermis interdigitates with the overlying rete ridges of the epidermis, between which the two layers interact through the basement membrane zone.
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The neural source of the visual P2 is difficult to ascertain given the limited spatial resolution of the ERP technique. Since the recordings obtained from the scalp reflect only the dipole moments created by post- synaptic potential changes, they are subject to several factors including orientation, magnitude, and number of generator dipoles. Thus, the observed topographies of the P2 observed in experimental conditions may not be indicative of their true source. It is thought that the visual P2 encompasses both a frontal and a posterior source component; in particular some of the neural activity may originate from the visual cortex in the occipital region, while the similar auditory P2 is likely generated at least in part in the auditory cortex in the temporal region and the reticular activating system.
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The hippocampus also receives a number of subcortical inputs. In Macaca fascicularis, these inputs include the amygdala (specifically the anterior amygdaloid area, the basolateral nucleus, and the periamygdaloid cortex), the medial septum and the diagonal band of Broca, the claustrum, the substantia innominata and the basal nucleus of Meynert, the thalamus (including the anterior nuclear complex, the laterodorsal nucleus, the paraventricular and parataenial nuclei, the nucleus reuniens, and the nucleus centralis medialis), the lateral preoptic and lateral hypothalamic areas, the supramammillary and retromammillary regions, the ventral tegmental area, the tegmental reticular fields, the raphe nuclei (the nucleus centralis superior and the dorsal raphe nucleus), the nucleus reticularis tegementi pontis, the periaqueductal gray, the dorsal tegmental nucleus, and the locus coeruleus. The hippocampus also receives direct monosynaptic projections from the cerebellar fastigial nucleus.
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Sensory information is processed and modified at each level in the chain by interneurons and input from other areas of the nervous system. For example, cells in the main trigeminal nucleus (Main V in the diagram below) receive input from the reticular formation and cerebral cortex. This information contributes to the final output of the cells in Main V to the thalamus. C = Cervical segment, S = Sacral segment, VPL = Ventral posterolateral nucleus, SI = Primary somatosensory cortex, VM = Ventromedial prefrontal cortex, MD = Medial dorsal thalamic nucleus, IL = Intralaminar nucleus, VPM = Ventral posteromedial nucleus, Main V = Main trigeminal nucleus, Spinal V = Spinal trigeminal nucleus Touch-position information from the body is carried to the thalamus by the medial lemniscus, and from the face by the trigeminal lemniscus (both the anterior and posterior trigeminothalamic tracts).
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Expression of this hairy-like bHLH transcription factor, which represses Neurogenin but is required for Ascl1, is progressively lost from the caudal thalamus but maintained in the prethalamus and in the stripe of rostral thalamic cells. In addition, studies on chick and mice have shown that blocking the Shh pathway leads to absence of the rostral thalamus and substantial decrease of the caudal thalamus. The rostral thalamus will give rise to the reticular nucleus mainly whereby the caudal thalamus will form the relay thalamus and will be further subdivided in the thalamic nuclei. In humans, a common genetic variation in the promoter region of the serotonin transporter (the SERT-long and -short allele: 5-HTTLPR) has been shown to affect the development of several regions of the thalamus in adults.
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The pontine tegmentum contains nuclei of the cranial nerves (trigeminal (5th), abducens (6th), facial (7th), and vestibulocochlear (8th) cranial nerve nuclei) and their associated fibre tracts, the tegmental pontine reticular nucleus, the mesopontine cholinergic system comprising the pedunculopontine nucleus and the laterodorsal tegmental nucleus, and in the respiratory center the pontine respiratory group – the pneumotaxic centre and the apneustic centre. Nearby important structures include the cranial nerve nuclei of the oculomotor (3rd) and trochlear (4th) nerve nuclei, which are located in the midbrain, the pontine nuclei, which are located within the basilar pons, and the raphe nucleus and the locus ceruleus, nuclei of cranial nerves 9-12, and the dorsal respiratory group, which are located further caudally in the brainstem. The dorsal respiratory group are connected to the pneumotaxic and apneustic centres of the pontine tegmentum.
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Art and Medicine Die Photographie als Hülfsmittel mikroskopischer Forschung Along with Camillo Golgi, he was a major proponent of the reticular theory that the brain's nervous system consisted of processes of contiguous cells fused to create a massive meshed network. Gerlach summed up his theory by stating: > the finest divisions of the protoplasmic processes ultimately take part in > the formation of the fine nerve fibre network which I consider to be an > essential constituent of the gray matter of the spinal cord. The divisions > are none other than the beginnings of this nerve fibre net. The cells of the > gray matter are therefore doubly connected by means the nerve process which > becomes the axis fibre and through the finest branches of the protoplasmic > processes which become a part of the fine nerve fibre net of the gray > matter.
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In the human brainstem, the solitary nucleus (SN) (nucleus of the solitary tract, nucleus solitarius, nucleus tractus solitarii) is a series of purely sensory nuclei (clusters of nerve cell bodies) forming a vertical column of grey matter embedded in the medulla oblongata. Through the center of the SN runs the solitary tract, a white bundle of nerve fibers, including fibers from the facial, glossopharyngeal and vagus nerves, that innervate the SN. The SN projects to, among other regions, the reticular formation, parasympathetic preganglionic neurons, hypothalamus and thalamus, forming circuits that contribute to autonomic regulation. Cells along the length of the SN are arranged roughly in accordance with function; for instance, cells involved in taste are located In the rostrum part, while those receiving information from cardio-respiratory and gastrointestinal processes are found in the caudal part.
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Human bone marrow derived Mesenchymal stem cell showing fibroblast-like morphology seen under phase contrast microscope (carl zeiss axiovert 40 CFL) at 63 x magnification An example of human mesenchymal stem cells imaged with a live cell imaging microscope Mesenchymal stem cells are characterized morphologically by a small cell body with a few cell processes that are long and thin. The cell body contains a large, round nucleus with a prominent nucleolus, which is surrounded by finely dispersed chromatin particles, giving the nucleus a clear appearance. The remainder of the cell body contains a small amount of Golgi apparatus, rough endoplasmic reticulum, mitochondria and polyribosomes. The cells, which are long and thin, are widely dispersed and the adjacent extracellular matrix is populated by a few reticular fibrils but is devoid of the other types of collagen fibrils.
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Although the synthesis of new materials has long been recognized as the most essential element in advancing technology, it generally remains more of an art than a science—in that the discovery of new compounds has mostly been serendipitous, using methods referred to by critics as 'shake and bake', ‘mix and wait', 'mash and smash' and 'heat and beat'. The reason is that the starting entities do maintain their structure during the reaction, leading to poor correlation between reactants and products. However, the design of an extended network that will maintain its structural integrity throughout the construction process can be realized by starting with well-defined and rigid molecular building blocks. In essence, reticular synthesis can be described as the process of assembling judiciously designed rigid secondary building units into predetermined ordered structures (networks), which are held together by strong bonding.
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Left right coordination is mediated by commissural and fore-hind as well as diagonal coordination is mediated by long-projecting propiospinal interneurons. The balance of the left-right alternation (mediated genetically identified V0d and V0v neuron classes) to left-synchronization promoting commissural interneurons (potentially mediated V3 neurons) determines whether walk and trot (alternating gaits) or gallop and bound (synchronous gaits) are expressed. This balance changes with increasing speed, potentially because of modulation by supraspinal drive from the MLR and mediated by the reticular formation, and causes speed dependent gait transitions characteristic for quadrupedal animals. The walk to trot transition potentially occurs because of the stronger decrease of extension than flexion phase durations with increasing locomotor speed and could be mediated by descending diagonal inhibition through V0d long propriospinal neurons, which leads to progressively increasing overlap between the diagonal limbs up until diagonal synchronization (trot).
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Horace Winchell Magoun (June 23, 1907 – March 6, 1991) studied medicine first at the Rhode Island State College and the Syracuse University, graduating in medicine in 1931. In 1934 earned a Ph.D. in anatomy at the Faculty of Medicine 'Northwestern University, and remained in it first as a university assistant (1934–1937) and then as professor of microscopic anatomy (1937–1950). In 1948, in collaboration with the Italian neurophysiologist Giuseppe Moruzzi, Magoun identified the brain center responsible for the state of sleep: electrical stimulation of the brain stem, by Moruzzi and Magoun found a link between the station cerebellum and motor cortex, producing EEG waves typical of a state of intense supervision. With further investigation showed that both the deep brain stimulation of this structure, which they named "reticular formation", caused the awakening of the animal, while its destruction made him fall into a coma permanent.
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Cerebrospinal fluid HCRT-1/OX-A is undetectable in up to 95% of patients with type 1 narcolepsy. The system which regulates sleep, arousal, and transitions between these states in humans is composed of three interconnected subsystems: the orexin projections from the lateral hypothalamus, the reticular activating system, and the ventrolateral preoptic nucleus. In narcoleptic individuals, these systems are all associated with impairments due to a greatly reduced number of hypothalamic orexin projection neurons and significantly fewer orexin neuropeptides in cerebrospinal fluid and neural tissue, compared to non-narcoleptic individuals. Those with narcolepsy generally experience the REM stage of sleep within five minutes of falling asleep, while people who do not have narcolepsy (unless they are significantly sleep deprived) do not experience REM until after a period of slow-wave sleep, which lasts for about the first hour or so of a sleep cycle.
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Further studies have shown that the beta-hairpin loops within the ankyrin repeat domain of ankyrin-B are required for the interaction with the inositol trisphosphate receptor, and a reduction of ankyrin-B in neonatal cardiomyocytes reduces the half-life of the inositol trisphosphate receptor by 3-fold and destabilizes its proper localization; all of these effects were rescued by reintroducing ankyrin-B. Moreover, a specific sequence in ankyrin-B (absent in other ankyrin isoforms) folds as an amphipathic alpha helix is required for normal levels of sodium-calcium exchanger, sodium potassium ATPase and inositol triphosphate receptor in cardiomyocytes, and is regulated by HDJ1/HSP40 binding to this region. Additional insights into ankyrin-B function have come from studies employing ankyrin-B transgenic animals. Cardiomyocytes from ankyrin-B (-/+) mice exhibited irregular spatial patterns and periodicity of calcium release, as well as abnormal distribution of the sarcomplasmic reticular calcium ATPase, SERCA2, and ryanodine receptors; effects that were rescued by transfection of ankyrin-B.
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For example, if a 530 Hz pure tone is presented to a subject's right ear, while a 520 Hz pure tone is presented to the subject's left ear, the listener will perceive the auditory illusion of a third tone, in addition to the two pure-tones presented to each ear. The third sound is called a binaural beat, and in this example would have a perceived pitch correlating to a frequency of 10 Hz, that being the difference between the 530 Hz and 520 Hz pure tones presented to each ear. Binaural-beat perception originates in the inferior colliculus of the midbrain and the superior olivary complex of the brainstem, where auditory signals from each ear are integrated and precipitate electrical impulses along neural pathways through the reticular formation up the midbrain to the thalamus, auditory cortex, and other cortical regions. Some potential benefits of binaural beats therapy may include: reduced stress, reduced anxiety, increased focus, increased concentration, increased motivation, increased confidence, and deeper meditation.
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Relationships between creative capitals, creative city and urban smartness With the very important book Reimagining Urbanism (Trento, ListLab, 2014) he has investigated and interpreted the challenges of western cities - and Sicilian one - in the age of never-ending metamorphosis not only as a powerful attractor of population, but also as a responsible subject of a new relationship with the suburban and rural areas, as activators of beautiful creative eco-systems based on new digital/physical citymakers. The book proposes an urbanism capable of producing resources for a new urban metabolism that can be reconciled with environmental protection, with the reduction of consumption, with the consolidation of the welfare state, food creation, as well as the promotion of innovative startups can stimulate the intelligence and creativity, to extend urban agriculture and recycling, to manage energy adaptation and climate efficiency of the city of the futureSee the Institute for Advanced Architecture of Catalonia 2014 Spring Lectures. With the new book Augmented City. A Paradigm Shift (Trento-Barcelona, ListLab, 2017) he proposes a new paradigm for more sensible, open source, intelligent, creative and resilient cities, based on recycle for being more productive, fluid and reticular.
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Oil painting by Clarke from the Via Crucis series, titled And He is Condemned (1983), exhibited at the reopening of the Robert Fraser Gallery At the start of 1980, Clarke began to paint in oils again after a period of working primarily graphically and in acrylic, and created his first constructions, in wood and steel, and designs for furniture. Clarke accepted a proposal to design stage sets for Kraftwerk, and collaborated on unrealised projects with David Bailey, with Brian Eno, and with Malcolm McLaren and Vivienne Westwood as designer of the aborted zine Chicken, whose creation was funded by EMI and filmed by BBC's Arena. Noticing the similarity between the reticular, Constructivist-derived symbols that dominated his work and the light-metering computergrams from the Olympus OM System cameras, he produced a series of technology-related paintings, including one titled Time Lag Zero for the headquarters of Olympus Optical (UK). Its unveiling at Langan's Brasserie by Patrick Lichfield for the fifth anniversary of Olympus UK was filmed by Granada Television as part of a documentary on Clarke and his work, released by ITV as Time Lag Zero: Impressions of Brian Clarke.
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