How to use pathogenically in a sentence? Find typical usage patterns (collocations)/phrases/context for "pathogenically" and check conjugation/comparative form for "pathogenically". Mastering all the usages of "pathogenically" from sentence examples published by news publications.
"Of the few strains that are, there is no clear consensus on why they are behaving pathogenically," she added.
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Verticillium klebahnii (or V. klebahnii) is a fungus often pathogenically inhabiting lettuce. It causes verticillium wilt (a disease state) in some plant species. It produces yellow-pigmented hyphae and microsclerotia, while producing abundant chlamydospores and resting mycelium. It is most closely related to V. tricorpus and V. isaacii.
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Chlamydia pecorum, also known as Chlamydophila pecorum is a species of Chlamydiaceae that has been isolated only from mammals: cattle, sheep, goats, koalas and swine. C. pecorum strains are serologically and pathogenically diverse. In the koalas, C. pecorum causes infections in the reproductive systems and urinary tract, as well as infertility, and death. It is considered one of the most important infectious disease of koalas.
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MS has been historically a clinically defined entity including several atypical presentations. Some auto-antibodies have been found in atypical MS cases, giving birth to separate disease families and restricting the previously wider concept of MS. The research in MS heterogeneity is trying to set apart all the pathogenically unrelated conditions that are currently included in the spectrum. It is an ongoing research and the list of separated conditions could grow in the future. First of all, anti-AQP4 autoantibodies were found in neuromyelitis optica (NMO), which was previously considered a MS variant.
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Many of the cytokines elevated in CRS are not produced by CAR-T cells, but by myeloid cells that are pathogenically licensed through T-cell-mediated activating mechanisms. For example, in vitro co-culture experiments have demonstrated IL-6, MCP-1, and MIP-1 are not produced by CAR-T cells, but rather by inflammatory myeloid lineage cells. In vivo models have demonstrated NSG (NOD/SCID/γ-chain deficient mice) with defects of both lymphocyte and myeloid lineage compartments do not develop CRS after CAR-T cell infusion. As a result, therapeutics to prevent or manage CRS largely focus on inhibition CAR-T cell cross-talk with inflammatory myeloid cells or blockade of downstream myeloid-derived cytokines.
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Pathogenically, it is a type II hypersensitivity reaction where circulating complement-fixing IgG antibodies bind to an antigen (a 180-kDa protein, BP-180) in the hemidesmosomes (attach basal cells of epidermis to the basal lamina and hence to dermis) of the dermoepidermal junction, leading to blister formation as loss of hemidesmosomes causes the epidermis to separate from dermis. The immune response is even more highly restricted to the NC16A domain. The primary site of autoimmunity seems not to be the skin, but the placenta, as antibodies bind not only to the basement membrane zone of the epidermis, but also to that of chorionic and amniotic epithelia. Aberrant expression of MHC class II molecules on the chorionic villi suggests an allogenic immune reaction to a placental matrix antigen, thought to be of paternal origin.
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