The prescription that the authors give is succinctly, if nonspecifically, captured in the title of the article.
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Your study, "How We Gather," explores the many ways people are finding religious meaning in secular or nonspecifically theistic communities.
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I fear it would assert itself, like a tour director, over the flights of fancy born of the nonspecifically occupied mind.
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They act nonspecifically in the body, meaning they don't work on one single body system or organ, at least according to their proponents.
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A white male character explains his martial art — which was made up by white men in the 1970s as a nonspecifically Asian but definitionally more powerful technique than those invented by actual Asian cultures — to an Asian-American, female expert in actual martial arts developed by actual Asian cultures.
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This became the eventual requirement detailed in Minsk II. To achieve those goals, known as the political package of Minsk II, Russia has agreed to a pullback of its forces — referred to in the accord nonspecifically as "foreign" troops — in eastern Ukraine only in conjunction with Ukraine amending its Constitution to decentralize power.
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Coomassie blue (also brilliant blue) nonspecifically stains proteins a strong blue colour. It is often used in gel electrophoresis.
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Higher concentrations result in the toxin absorbing nonspecifically to the lipid bilayer and forming large, Ca2+ permissive pores. This in turn results in massive necrosis and other secondary cellular reactions triggered by the uncontrolled Ca2+ influx.
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One site, termed the C-terminal subsite, resembles a classic "hot-spot" with predicted salt-bridges and electrostatic interactions. The other site, termed the alpha-clamp subsite, is a deep cleft that nonspecifically binds the N-terminal alpha helix and short beta strand of LF, guiding the N-terminus of the substrate towards the PA prechannel lumen. In this manner, the alpha clamp aids in protein translocation, nonspecifically binding and subsequently unfolding secondary structure as it unfurls from the substrate.Feld GK, Brown MJ, Krantz BA. Ratcheting up protein translocation with anthrax toxin.
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Finally, C5 is unique in that it readily adsorbs in native form to unsensitized erythrocytes. This nonspecifically bound C5 remains firmly attached, although it may be specifically utilized as a source of C5 by an ongoing complement reaction.
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Nucleotidomimetics do not generally qualify as foldamers. Most are designed to mimic single DNA bases, nucleosides, or nucleotides in order to nonspecifically target DNA. These have several different medicinal uses including anti-cancer, anti-viral, and anti-fungal applications.
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Thalamic interneurons process sensory information and signal different regions of the thalamic nuclei. These nuclei extend to relay cells, which in turn innervate distinct areas of the cortex via thalamocortical fibers. Either specifically or nonspecifically, TC relay cells project specifically to organized areas of the cortex directly and nonspecifically project to large areas of cortex through the innervation of many interconnected collateral axons. According to Jones (2001) there are two primary types of relay neurons in the thalamus of primates–core cells and matrix cells–each creating distinct pathways to various parts and layers throughout the cerebral cortex.
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Rather than suppressing the immune system nonspecifically, as corticosteroids do, they target the responses of individual [types of] immune cells. Some of these drugs are already FDA- approved for treatment of rheumatoid arthritis, however due to high-toxicity, its use is limited.
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The first method consists of using fluorescent dyes that are retained nonspecifically in between the double strands. The second method involves probes that code for specific sequences and are fluorescently labeled. Detection of DNA using these methods can only be seen after the hybridization of probes with its complementary DNA takes place. An interesting technique combination is real-time PCR and reverse transcription.
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Active secretion within exosomes has been discussed, but it is still unknown whether this is a relevant or relatively minor source of cfDNA. cfDNA circulates predominantly as nucleosomes, which are nuclear complexes of histones and DNA. They are frequently nonspecifically elevated in cancer but may be more specific for monitoring cytotoxic cancer therapy, mainly for the early estimation of therapy efficacy.
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The conversion of diazinon to diazoxon (Reaction 1) is performed by the liver microsomal enzyme system and requires O2 and NADPH. Diazinon can also be decomposed via oxidation in the liver (Reaction 2). Both reactions are possible, and likely are catalyzed nonspecifically by the same mixed function oxidase. Diazoxon is further broken down by hydrolases in the microsomal and other subcellular functions within the liver (Reaction 3).
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The name differential scanning fluorimetry (DSF) was introduced later but thermofluor is preferable as thermofluor is no longer trademarked and differential scanning fluorimetry is easily confused with differential scanning calorimetry. SYPRO Orange binds nonspecifically to hydrophobic surfaces, and water strongly quenches its fluorescence. When the protein unfolds, the exposed hydrophobic surfaces bind the dye, resulting in an increase in fluorescence by excluding water. Detergent micelles will also bind the dye and increase background noise dramatically.
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Diagram depicting a representative pan-assay interference compound. The drug- like molecule specifically interacts with target B, but the PAINS-like compound non-specifically interacts with multiple targets Pan-assay interference compounds (PAINS) are chemical compounds that often give false positive results in high-throughput screens. PAINS tend to react nonspecifically with numerous biological targets rather than specifically affecting one desired target. A number of disruptive functional groups are shared by many PAINS.
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Ausubel distinguishes between two kinds of advance organizer: comparative and expository. 1\. Comparative Organizers The main goal of comparative organizers is to activate existing schemas. Similarly, they act as reminders to bring into the working memory of what one may not realize is relevant. By acting as reminders, the organizer points out explicitly "whether already established anchoring ideas are nonspecifically or specifically relevant to the learning material" (Ausubel & Robinson, 1969, p. 146).
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Glycosidic bond cleavage follows a “pinch-push-pull” mechanism using the five conserved motifs. Pinch: UDG scans DNA for uracil by nonspecifically binding to the strand and creating a kink in the backbone, thereby positioning the selected base for detection. The Pro-rich and Gly-Ser loops form polar contacts with the 3’ and 5’ phosphates flanking the examined base. This compression of the DNA backbone, or “pinch,” allows for close contact between UDG and base of interest.
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Researchers found that dihydroalprenolol was most likely associated nonspecifically to membrane lipids because of it ability to bind to β-1 and β-2 receptors and a low-affinity site. In 1986, researchers hypothesized that there was a relationship between dihydroalprenolol and major depression. So they studied an olfactory bulbectomized rat model of major depression. Although dihydroalprenolol's binding in the midbrain was the same, there was an increased binding of 30% in the pons and 15% in the hippocampus.
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Naïve D. melanogaster will also attempt to court females that are not yet sexually mature, and other males. D. melanogaster males show little to no preference for D. melanogaster females over females of other species or even other male flies. However, after D. simulans or other flies incapable of copulation have rejected the males’ advances, D. melanogaster males are much less likely to spend time courting nonspecifically in the future. This apparent learned behavior modification seems to be evolutionarily significant, as it allows the males to avoid investing energy into futile sexual encounters.
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Homeodomains can bind both specifically and nonspecifically to B-DNA with the C-terminal recognition helix aligning in the DNA's major groove and the unstructured peptide "tail" at the N-terminus aligning in the minor groove. The recognition helix and the inter-helix loops are rich in arginine and lysine residues, which form hydrogen bonds to the DNA backbone. Conserved hydrophobic residues in the center of the recognition helix aid in stabilizing the helix packing. Homeodomain proteins show a preference for the DNA sequence 5'-TAAT-3'; sequence-independent binding occurs with significantly lower affinity.
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Generally speaking, the data analysis can be divided into three major steps: During the first step, the captured fluorescence signals from the array are normalized, using control signals derived from the same or a second chip. Such control signals tell which probes on the array were hybridized correctly and which bound nonspecifically. In the second step, numerical and statistical tests are applied to control data and IP fraction data to identify POI-enriched regions along the genome. The following three methods are used widely: median percentile rank, single-array error, and sliding-window.
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2007, 27(9) 1533-1539 a large group of researchers who are active in this field agreed to a consensus nomenclature for these terms, with the intent of making the literature in this field more transparent to non-specialists. The convention involves use of the subscripts p for quantities referred to plasma and ND for quantities referred to the free plus nonspecifically bound concentration in brain (NonDisplaceable). Under the consensus nomenclature, the parameters referred to above as f1 and BP1 are now called fp and BPp, while f2 and BP2 are called fND and BPND.
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The consequent improvements in productivity can be of economic benefit to livestock producers for many reasons, including greater overall efficiency of feedstuff use. Selenium yeast supplementation of food-animal diets has an added nutritional benefit to human consumers of food-animal products. Dietary selenomethionine-containing plant or yeast protein can be also stored nonspecifically in animal protein, which can result in nutritionally useful selenium content in meat, milk, and eggs. Consequently, strategies to supplement animal feed with selenium yeast have led to the development of selenium-rich functional foods, including selenium- enriched eggs and meats for human consumption.
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Based on chromatin immunoprecipitation (ChIP) experiments, ParB has the ability to bind not only to high-affinity parS sites but also to adjacent nonspecific DNA, a behavior known as "spreading" . The ParB-DNA complex is thought to be translocated by a Brownian ratchet mechanism involving the ParA ATPase: ParA binds DNA nonspecifically in its ATP-bound state but much more weakly in its ADP-bound state . The ParB-DNA complex binds to ATP-bound ParA , stimulating its ATPase activity and its dissociation from DNA. In this way, the ParB-DNA complex can be translocated by chasing a receding wave .
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It elicits a warm and pungent flavour. The in vitro biological activity of polygodial has been reported in the scientific literature to include antifungal and antimicrobial activities, antihyperalgesia, potent attachment-inhibitory activity, insect antifeedant activity, antinociception, vasorelaxing action in vessels of rabbit and guinea pig, anti-inflammatory and antiallergic activities. Polygodial’s primary antifungal action is as a nonionic surfactant, disrupting the lipid-protein interface of integral proteins nonspecifically, denaturing their functional conformation. It is also likely that polygodial permeates by passive diffusion across the plasma membrane, and once inside the cells may react with a variety of intracellular compounds.
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