There are two major types of narcolepsy: narcolepsy with cataplexy and narcolepsy without cataplexy.
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But narcolepsy is manageable, and people with narcolepsy can lead "full and rewarding lives" thanks to different treatment regimens.
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When people learn that I have narcolepsy, their eyes often get big and they say, 'I've never met anyone with narcolepsy before.
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Julie Flygare, a narcolepsy advocate and founder of Project Sleep, says this type of listening has made all the difference in her experience with narcolepsy.
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What it means to live with narcolepsy Narcolepsy affects about one in 2,000 people in the United States, according to the Division of Sleep Medicine at Harvard Medical School.
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"It didn't look like a candidate for narcolepsy," says Mignot.
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It could also point toward depression, sleep apnea, or narcolepsy.
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To some extent, that's what people with narcolepsy go through.
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This ignores the fact that narcolepsy is probably undiagnosed in many people, and that someone who develops narcolepsy in their teens and lives into their 80s would need some 25,000 doses over their lifetime.
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Creators: How long have you suffered from narcolepsy and sleep paralysis?
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Since becoming pregnant almost three years ago, my narcolepsy symptoms have receded.
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In human narcolepsy, there are many ways to break the orexin system.
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Broadly spoke to Dr Emmanuel Mignot, a world leading expert on narcolepsy.
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Countless online forums are dedicated to narcolepsy sufferers struggling with suicidal thoughts.
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Pitolisant is licensed in Europe to treat narcolepsy, a neurological sleep disorder.
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HLA-DQB2000*22018 is pretty common–around one in four people in Europe boasts a copy–but it plays a key role in many cases of narcolepsy, and is present in 98 percent of those with narcolepsy and cataplexy.
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In narcolepsy, my complicated understanding of science, health, religion, and personal experience intersect.
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Still, nine years later, people who suffer from narcolepsy aren't using Orexin-A.
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Modafinil is a generic drug usually prescribed for sleep disorders such as narcolepsy.
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But it's interesting with the sleepiness of narcolepsy that can be really invisible.
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Kleine-Levin is thought to be a genetic, immune-triggered disease, like narcolepsy.
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Or what if they have narcolepsy, or what if they have sleep apnea?
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Get creative with a hockey team that is the athletic manifestation of narcolepsy.
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HLA-DQB1*0602 is pretty common -- around one in four people in Europe boasts a copy -- but it plays a key role in many cases of narcolepsy, and is present in 98 per cent of those with narcolepsy and cataplexy.
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In addition, methamphetamine is approved to treat obesity and d-amphetamine to treat narcolepsy.
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Dubbed cataplectic attacks, it is thought that 70 percent of narcolepsy sufferers experience cataplexy.
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Ritalin, for example, which is used by people with ADHD and narcolepsy, improves concentration.
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There's a brand of GHB called Xyrem and it's prescribed to people with narcolepsy.
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Unbeknownst to me, hallucinations and sleep paralysis are two of the most common narcolepsy symptoms.
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When many people think of narcolepsy, they envision someone randomly dropping into a deep sleep.
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Xyrem is an approved treatment for excessive daytime sleepiness and cataplexy in patients with narcolepsy.
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Rebis Abolar: Narcolepsy is a genetic disorder, so really, I've had it my whole life.
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In most cases, however, narcolepsy is caused by the series of unfortunate events outlined above.
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I know a lot of people who have narcolepsy go through this kind of thing.
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I'm luckier still to live in a time and place where narcolepsy is a recognized disorder.
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It's an inaccurate perception of narcolepsy, one often misportrayed or played for laughs in the media.
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One founder told CNBC that he uses Provigil, a drug designed for narcolepsy, to stay alert.
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If people know one thing about narcolepsy, it's that it involves frequent bouts of uncontrollable sleepiness.
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"I describe my narcolepsy to people like a little kid who needs a nap," she said.
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But that narrative is complicated by the fact that I was diagnosed with narcolepsy in my twenties.
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According to the National Sleep Foundation, lucid dreaming tends to be more common in people with narcolepsy.
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These studies prompted a trial of opioids (using the drug codeine) for narcolepsy patients published in 1986.
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People with narcolepsy have a dysfunctional immune system that kills off the cells responsible for making hypocretin.
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The drug, solriamfetol, will treat excessive sleepiness in adult patients with narcolepsy or obstructive sleep apnea (OSA).
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And it's a six-foot-something man with Matthew McConaughey-if-he-had-narcolepsy eyes: Jay Cutler.
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Jazz Pharmaceuticals (JAZZ) struck a patent settlement with Britain's Hikma Pharmaceuticals related to the narcolepsy drug Xyrem.
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Jazz Pharmaceuticals — Jazz struck a patent settlement with Britain's Hikma Pharmaceuticals related to the narcolepsy drug Xyrem.
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At least half of participants could correctly define sleep disorders such as sleep apnea, insomnia and narcolepsy.
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Modafinil, used in the treatment of narcolepsy, and piracetam, for dementia, are two of the most popular.
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A drug that promoted sleepiness was not the application that most people with narcolepsy were looking for.
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Ms. Perich said she was fired for pursuing an employment discrimination claim based on a disability, narcolepsy.
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"I'd say that having narcolepsy on an everyday basis is much harder than running a marathon," Flygare said.
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Back in the 1s, the idea of locating the gene for canine narcolepsy was off-the-scale ambitious.
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I ask him if the story of the discovery of narcolepsy is really as good as it appears.
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Then came the breakthrough: a litter of around seven Doberman puppies, all of them with narcolepsy and cataplexy.
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People with narcolepsy are slightly but significantly more likely to be born in March (as, indeed, I was).
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He also has an odd variety of narcolepsy that friends and colleagues say can be difficult to detect.
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However, amphetamines can also be prescribed for narcolepsy, and methamphetamine can be used to treat ADHD and obesity.
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For example, amphetamines can be prescribed for narcolepsy, and methamphetamine can be used to treat ADHD and obesity.
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Consider Xyrem, a drug for narcolepsy made by Jazz Pharmaceuticals, whose price rose 841 percent over seven years.
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Although an estimated 200,000 people in the United States have narcolepsy, only 25 percent are diagnosed and receive treatment.
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Narcolepsy is a condition that causes people to lose consciousness and fall asleep in the middle of the day.
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But the FMCSA is considering exemptions for these two truck drivers, because they are receiving medical treatment for narcolepsy.
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The narcolepsy medication modafinil is among the most common medications in the United States to be consumed off-label.
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Of course, Adderall is also used to treat narcolepsy and to facilitate wakefulness in soldiers, among many other things.
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And EEG, which is used to diagnose disorders like narcolepsy, Alzheimer's, and certain brain disorders, is an imperfect tool.
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Dr. Jouvet also conducted early research on Modafinil, a stimulant used to successfully treat narcolepsy and other sleep disorders.
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Some guy tried to talk to me about universal basic income yesterday and I just pretended I had narcolepsy.
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About 60 percent of narcolepsy patients are initially misdiagnosed, often with depression but sometimes with schizophrenia, as I had feared.
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Having once been a young teen with narcolepsy, I can imagine how scary that must have been for the child.
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Having PMDD at a PMDD conference could not be more clichéd — it was like falling asleep at a narcolepsy conference.
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Xyrem is an approved treatment for both excessive daytime sleepiness and cataplexy in patients with narcolepsy, a chronic neurological disorder.
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I'm hoping I can get my art into some galleries and start making a name for myself and for narcolepsy.
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"Narcolepsy has as much impact on people's lives and on their quality of life as diseases like epilepsy," Scammell said.
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Modafinil was developed in the 1970s by a French professor of experimental medicine to treat narcolepsy and other sleep disorders.
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There are some occupations that are not suitable for someone with untreated narcolepsy and this is probably one of them.
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Adderall is a drug used to treat attention deficit hyperactivity disorder (ADHD) as well as sleep disorders such as narcolepsy.
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In short, people who have narcolepsy don't get much sleep and when they do sleep it's rarely of good quality.
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They just thought I had chronic fatigue but after I did these tests they found out that I had narcolepsy.
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The only thing I actually ironically ended up getting was narcolepsy, which Phoenix's character has in My Own Private Idaho.
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Her brother also joins the organization, as a proofreader of nonsensical texts that induce in him a kind of narcolepsy.
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Some speculate that this caused her debilitating "spells" or blackouts, while others believe she may have had epilepsy or narcolepsy.
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When my sleep doctor first diagnosed me, I balked because my symptoms didn't conform to the depictions of narcolepsy I'd seen.
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That fear might have encouraged researchers to give up studying the connection between opioids and narcolepsy after a single poor study.
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Xyrem is the only approved treatment for both excessive daytime sleepiness and cataplexy in patients with narcolepsy, a chronic neurological disorder.
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Although she never said anything to me in class about my narcolepsy, she wrote me a long note at semester's end.
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According to the FDA, modafinil is intended to bolster "wakefulness" in people with narcolepsy, obstructive sleep apnea or shift work disorder.
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Henry's book Sleepyhead: Neuroscience, narcolepsy and the search for a good night will be published by Profile Books in March 2018.
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Originally synthesized in France in the 1970s, modafinil was approved as a treatment for narcolepsy and other sleep disorders in 1998.
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Jazz also makes cancer drugs but gets most of its revenue from Xyrem, a drug used to treat side effects of narcolepsy.
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"It's thought that the fundamental problem in narcolepsy is that they're moving between states of consciousness too quickly and abruptly," Wamsley says.
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In short, most cases of narcolepsy are probably the result of an unfortunate combination of events that create the perfect immunological storm.
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Around this time, the Doberman project in Stanford was on the verge of unravelling the genetic basis of narcolepsy in this breed.
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In theory, it should be possible to transplant this into the brains of people with narcolepsy and restore some of the function.
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So I asked some friends who have Crohn's disease, asthma, and narcolepsy how their sex lives have been affected by their illnesses.
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And a vaccine used in some European countries against H1N1 flu in 2009 caused some people to develop the sleep disorder narcolepsy.
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In a person with narcolepsy, the neurotransmitters responsible for controlling sleep have died, blurring the divide between wakefulness and sleep, dreaming and seeing.
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I'm lucky that a sleep doctor correctly diagnosed me with narcolepsy when I first sought help, almost 13 years after my spiritual experience.
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Teva kept a generic of Provigil, a drug used to treat narcolepsy, from entering the market for almost six years, according to Becerra.
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"Sometimes drowsy driving is caused by a medical disorder such as sleep apnea, narcolepsy or a drug side effect," Redelmeier said by email.
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After decades of clinical trials in France, the US Food and Drug Administration (FDA) okayed modafinil as a treatment for narcolepsy in 1998.
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But in narcolepsy, the hippocampus might stay in "write" mode during sleep, encoding dreams as real experiences as it would when you're awake.
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In the case of narcolepsy, it seems that those of us born in March are just a little bit more vulnerable than others.
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Here he is on Garth Hudson, the Band's multi-instrumentalist: "He had narcolepsy and could fall asleep at any time," the book recounts.
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Boyer and McCurdy worked on a 2008 case study of a man who mixed kratom and the narcolepsy drug modafinil and experienced seizures.
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We spoke to Alobar about how he turns his dreams into art and seeks to change the way narcolepsy is perceived in popular culture.
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And so, with doubts and cracks entering his portrait, and no narcolepsy pills to protect him, Gary's struggle is not for infallibility, but resilience.
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"In narcolepsy patients, this was definitely something they were really suffering from," Wamsley says, even though it's not an official symptom of the disorder.
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When he got wind that Yanagisawa had engineered a mouse lacking orexins that slept in a manner characteristic of narcolepsy, the race was on.
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Narcolepsy is a neurological sleep disorder that messes up the sleep cycle, causing people with the condition to be extremely sleepy during waking hours.
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VICE asked Claire*, a 26-year-old Torontonian who was diagnosed with narcolepsy four years ago, how she copes without ever really feeling rested.
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Will you remember an exhausted Helen melodramatically Googling "Can Narcolepsy Kill You," or Joanie referring to her boss's unborn child as a "carbon bomb"?
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The hand of modafinil, the drug designed to treat narcolepsy and used by fighter pilots to stay sharp, is all over university coursework these days.
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Dedekind Cut tweeted about his intentions for the track this past Friday, September 30, suggesting that it might come in handy for listeners with narcolepsy.
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On the hunt Around this time, the Doberman project in Stanford was on the verge of unraveling the genetic basis of narcolepsy in this breed.
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While the symptoms of narcolepsy can vary wildly from one person to the next, the underlying pathology—the absence of orexins—is still the same.
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Image: sferrario1968 (Pixabay)A new study could revive an abandoned theory about how to treat narcolepsy, the thus-far incurable disorder that makes people chronically sleepy.
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"Narcolepsy is very disabling to people as they often get diagnosed young and stop their education and drop out of high school or college," Koffler said.
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Then, a U.S. court overturned the conviction of drugs salesman Alfred Caronia, who was caught talking to physicians about unapproved uses for the narcolepsy drug Xyrem.
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Round size and year: $295 million in 2018More about Harmony Biosciences: The Pennsylvania-based biotech was founded in 2017 and makes a new medication for narcolepsy.
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"We hope to discover exactly where in the brain the dysfunction occurs that causes narcolepsy," Mitler had told the newspapers soon after Monique's arrival at Stanford.
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The fact that narcolepsy appeared to be more common in some breeds than others suggested there could be some kind of genetic basis to the disorder.
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"Narcolepsy has given us a thread we can pull on to unravel a lot about what underlies the systems that govern wakefulness and sleep," he says.
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This has been a long-term project for Masashi Yanagisawa, who was in the race with Mignot to link the orexins with narcolepsy 20 years ago.
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Even more compellingly perhaps, the orchestrating role that the orexins play in the brain suggests the market for such a drug would go far beyond narcolepsy.
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Extreme tiredness from narcolepsy can lead to low sex drive or impotence, according to the Mayo Clinic, and some narcoleptics will even fall asleep during sex.
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It helps with mood but it has stimulant like effects that so far with my narcolepsy has helped me enough that I can come to work.
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Bangalore-based artist Sonaksha Iyengar has launched a series of gorgeous illustrations on Instagram called #AtoZofMentalHealth, through which she depicts conditions like anxiety, PTSD and narcolepsy.
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As a result, the United States was spared a controversy over an unpredictable side effect — narcolepsy — that struck people in Finland who got the newer shots.
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According to Meir H. Kryger, editor of Principles and Practice of Sleep Medicine, doctors are often unfamiliar with sleep disorders and miss the classic symptoms of narcolepsy.
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Even if it was certain that opioids are reversing cataplexy, though, that doesn't mean we'll be able to use them as a narcolepsy treatment, given their risks.
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One study has suggested that some narcolepsy symptoms, such as sleepiness and cataplexy, can decrease with age, but it's unclear if that might apply to all symptoms.
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The department said Jazz similarly asked a foundation to set up funds to cover copays for patients using its narcolepsy treatment Xyrem and its pain medication Prialt.
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The decision is a big win for the drugmaker whose patents covering its blockbuster narcolepsy drug, Xyrem, was declared invalid by a U.S. appeals court in July.
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However, the millions of us with narcolepsy are still hoping for a drug that could work in the brain to rouse rather than silence the orexin system.
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Scientists are looking for genetic signatures in other sleep disorders, such as insomnia and narcolepsy, which all together affect an estimated 50 million to 73 million Americans.
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Yet while there are drugs that can help manage the worst of the symptoms of narcolepsy, none of these comes close to repairing the underlying brain damage.
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Back at Stanford, Mignot heard about the two papers, but there was no reason to imagine this new pathway had anything to do with narcolepsy or sleep.
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Thomas Scammell, a narcolepsy expert at Harvard Medical School and Beth Israel Deaconess Medical Center, is encouraged by the findings, though he cautions reading too much into them.
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Preliminary findings from these screening showed U.S. consumers had purchased certain unapproved drug products from abroad to treat depression, narcolepsy, high cholesterol, glaucoma, and asthma, among other conditions.
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Shortly after my 215st birthday, though, I began to experience symptoms of narcolepsy, a rare but not-so-rare disorder thought to affect around one in 220,2185 people.
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Shortly after my 21st birthday, though, I began to experience symptoms of narcolepsy, a rare but not-so-rare disorder thought to affect around one in 2,500 people.
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Recently, his lab has developed methods to do something similar for people with narcolepsy, starting with a skin cell and ending up with a fully functional orexin neuron.
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Friday's edition of the Federal Register contains new safety requirements for public transportation systems, truck drivers with narcolepsy and a ban on a new form of synthetic marijuana.
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I have a sleep disorder similar to narcolepsy that one of my medications helps mitigate, but even with treatment I tend to run out of steam relatively early.
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John Crowley's listless direction and a cast apparently afflicted with narcolepsy make this the first big bomb of #TIFF29 Some books were never meant to be movies. pic.twitter.
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In one case, Kryger had a 12-year-old narcolepsy patient who was admitted to a psychiatric ward where a resident physician thought the pre-teen's hallucinations indicated schizophrenia.
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Narcolepsy is one, and it's related to a condition called hypersomnia, which is where where people might sleep for upwards of 16 hours a day and still feel sleepy.
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The approval comes as Jazz is trying to reduce its reliance on its blockbuster narcolepsy drug, Xyrem, whose patents were declared invalid by a U.S. appeals court in July.
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The sleeping part of narcolepsy is kind of its hallmark, but it's all the other symptoms, ones that most people don't really know about, that affect me the most.
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That could be a specific sleep disorder (such as narcolepsy or idiopathic hypersomnia), a medical condition (such as sleep apnea), or a medication (such as antihistamines or beta-blockers).
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When vets at the University of Saskatchewan observed Monique, they suspected these were bouts of cataplexy, and hence figured this might be a case of narcolepsy with accompanying cataplexy.
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Trucks: The Federal Motor Carrier Safety Administration (FMCSA) is considering exempting two truck drivers who have narcolepsy from rules that would otherwise prohibit them from operating commercial motor vehicles.
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In 2012, the 2nd U.S. Circuit Court of Appeals overturned the conviction of a drug salesman for promoting Jazz Pharmaceuticals' narcolepsy drug Xyrem off-label, also on First Amendment grounds.
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Through his materials, he seizes visions that appear to him in the throes of sleep paralysis, a symptom of the narcolepsy he says he was diagnosed with in high school.
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Unless you have reason to believe you have narcolepsy (meaning you have intense, sudden episodes of sleepiness even during the day), Dr. Kothare says you're most likely in fine standing.
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By preventing the orexins from binding to their receptors, Belsomra effectively creates an acute case of narcolepsy, but where the fog, ideally, will have started to lift by the morning.
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"So it was natural to ask if opiates would reverse narcolepsy," senior author Jerry Siegel, a neuroscientist at the Brain Research Institute at the University of California, Los Angeles, told Gizmodo.
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The new study, published today in Nature Communications, highlights 15 different genetic variants associated with being a morning person, including traits associated with narcolepsy, prolonged REM sleep, and extended circadian rhythms.
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The national charity Narcolepsy UK said that as some NHS wards don't offer it, sufferers have to "jump through hoops" to access, which includes going through organizations like Clinical Commissioning Groups.
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In the 1960s the drug was prescribed to treat narcolepsy and depression but by the 1980s the medical community determined that Captagon's addictive properties outweighed clinical benefits and it was banned.
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Originally developed to treat sleep disorders such as narcolepsy, the drug Modafinil has become popular among members of the general public as a way to increase focus and help retain information.
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Ritalin, or methylphenidate, is in a class of medications called central nervous system stimulants, which are often used in children and adults to help control symptoms of ADHD or to treat narcolepsy.
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There is a widespread perception that narcolepsy is a rare disorder with a small market, so any pharmaceutical research and development in this area would be unlikely to reap a significant return.
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The Prozac made her drowsy, so he prescribed two hundred milligrams of Provigil, a drug for narcolepsy that is often taken by soldiers and truck drivers to stay awake during overnight shifts.
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And because that same neurotransmitter seems to play a role in making people without narcolepsy vulnerable to addiction, finding a way to create the opposite effect might just help treat addiction to boot.
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The drug was first used in the 1960s to treat attention deficit hyperactivity disorder and narcolepsy but became illegal in most countries, including the U.S., in the 1980s after its addictiveness became apparent.
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Nonetheless, the documents detailing VA's current experiments on dogs focus primarily on narcolepsy and heart attack research, which do not seem to fall into VA's enumerated research priorities listed in the budget proposal.
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It is probably safe to say that people like Franklin Delano Roosevelt (polio), Harriet Tubman (narcolepsy) or even the Oscar-winning actress Marlee Matlin (deafness) succeeded both despite and because of their impairments.
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The symptoms of narcolepsy, especially cataplexy, are caused by having incredibly low levels of hypocretin (also called orexin), a chemical produced in the brain that helps govern our sense of wakefulness, among other things.
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Narcolepsy is a chronic sleep disorder with overwhelming daytime drowsiness and sudden attacks of sleep, while obstructive sleep apnea is a potentially serious sleep disorder that can cause breathing to repeatedly stop and start.
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"It's like situational narcolepsy; the minute you start talking about the tax code, you've lost your audience," said Erica Payne, a progressive strategist and president of the Patriotic Millionaires, the group making the endorsements.
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I am delighted to see these developments, but the millions of us with narcolepsy are still hoping for a drug that could work in the brain to rouse rather than silence the orexin system.
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Injections of this molecule into narcoleptic mice significantly improves their wakefulness and cataplexy and reduces the abundance of the REM stage of sleep in which most dreaming occurs (one of the characteristics of narcolepsy).
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Another study available on the National Center for Biotechnology Information found "no signs of abnormal development" and "no adverse reactions" in two infants whose mothers were treated for narcolepsy with prescribed doses of amphetamine.
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On Bachelor in Paradise, Katie Morton's main stressor seems to be whether her boyfriend Chris Bukowski is fully committed to their relationship — but behind the scenes, she's also trying to deal with her narcolepsy.
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Nicholls, a science journalist in England, chose the topic of sleep in part because of his personal experience with narcolepsy, a rare neurological disorder that impacts the brain's ability to control sleep-wake cycles.
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"No mother of a 15-year-old with narcolepsy would sign onto us giving them several doses of morphine a day," he said, especially when there are other widely available and generally safe treatments around.
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Because methamphetamine doesn't share the same prescription distribution as opioids—pharmaceutical methamphetamine (Desoxyn) is only prescribed in cases of severe narcolepsy, ADD, and morbid obesity—its usage rate will likely never rival that of opioids.
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According to the US-based National Institute of Neurological Disorders and Stroke, people with narcolepsy experience "sleep attacks"—irresistible bouts of sleep—that can strike at any time and last from a few seconds to minutes.
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The former Penn State player alleges he was retaliated against for making the reports, including scorn from coaches, "irrational and inappropriate censure" by the team's academic adviser and denial of medical accommodations to treat anxiety and narcolepsy.
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In 2007, Flygare, then a 24-year-old law student, was diagnosed with narcolepsy with cataplexy, a neurological disorder that causes chronic sleepiness and, in her case, symptoms of brief episodes of muscle weakness triggered by strong emotions.
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In passing, he also told us about narcolepsy, a rare condition that could cause people to sink into slumber at any moment and that had other fascinating features, such as vivid hallucinations and abrupt loss of muscle control.
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Studies have also shown that orgasm can be a trigger for cataplexy, a narcolepsy-related condition that can cause someone to collapse from muscle weakness (yet remain conscious) at the onset of extreme emotions—fear, laughter, or orgasm.
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Although narcolepsy didn't exist as a diagnosis during her lifetime, the most famous person in history with narcoleptic symptoms was the Underground Railroad conductor and Civil War scout Harriet Tubman, who believed God spoke to her through her hallucinations.
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I can never reconstruct the combination of factors that led to the onset of my own narcolepsy, but the stage was set at the moment of my conception in 2000, at around the time of Monique's birth in Saskatchewan.
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Unbeknownst to most of us, for decades, the VA Medical Center in Los Angeles has been breeding Dobermans to have narcolepsy and was about to undertake a new project to inject 18 of them with methamphetamine and kill them.
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I can never reconstruct the combination of factors that led to the onset of my own narcolepsy, but the stage was set at the moment of my conception in 22015, at around the time of Monique's birth in Saskatchewan.
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There's an underlying puzzle (narcolepsy), an origin story (Monique), foresight (Dement), ambition (Mignot), technological developments (genetics), a photogenic animal (Dobermans), a race (with Yanagisawa), it looks like science (optogenetics) and there's a still-higher purpose (sleep and the brain).
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Watch more from VICE: Sensory Deprivation Tanks Napping can reverse some of the negative effects of sleep deprivation (that is, if you're a normal sleeper with regular sleep and wake schedules—let's leave out people with sleep disorders like narcolepsy).
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Kahn, who weighed 300 pounds and suffered from narcolepsy, had gained renown with his book On Thermonuclear War, in which he considered every facet of nuclear disaster: how to avoid it, how to win, and how to rebuild civilization afterward.
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What there is, though, is overwhelming evidence that the most common cause of narcolepsy is an autoimmune attack, where the body's immune system mishandles an upper respiratory infection and mistakenly wipes out the estimated 2185,21 neurons in the center of the brain.
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Dement made the decision to focus on Dobermans and, by the end of the 280s, he was the proud custodian of a large colony and had established that narcolepsy in this breed was caused by the transmission of a single recessive gene.
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Erin Wamsley, a psychology professor at Furman University, led a study that found an overwhelming link between dream delusions and people with type 1 narcolepsy, the type accompanied by cataplexy, a complete and sudden muscle paralysis often brought on by strong emotions.
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As Wamsley reported: Healthy people became "very briefly confused about a minor thing that's of no consequence" while "the narcolepsy patients were confused for longer periods of time about more serious things that a typical person would not be confused about," Wamsley says.
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There is now overwhelming evidence that by far the most common cause of narcolepsy is an autoimmune attack, where the body's immune system mishandles an upper respiratory infection and mistakenly wipes out the estimated 30,000 neurons in the center of the brain.
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Dement made the decision to focus on Dobermans and, by the end of the 2000s, he was the proud custodian of a large colony and had established that narcolepsy in this breed was caused by the transmission of a single recessive gene.
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What we now know about orexins also helps explain why losing just a few tens of thousands of cells should result in a disabling, multi-symptomatic disorder like narcolepsy—something that messes with wakefulness and sleep, body temperature, metabolism, feeding, motivation and mood.
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About 2100 drugs or classes of drugs are subject to such risk-management programs, including the narcolepsy drug sodium oxybate, the antipsychotic drug olanzapine and the acne drug isotretinoin, which used to be branded as Accutane and can cause severe birth defects.
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"After all this studying that I did, I kind of felt like we were caught in this catch-53, where we don't like these misperceptions and these jokes that people make about narcolepsy, so then we're not sharing that we have it," Flygare said.
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Gary reveals early on that he suffers from narcolepsy, and that he spent ten years braced by a heavy cocktail of prescription drugs that removed his capacity for self-reflection and minimized his perception of risk, causing him to partake in "completely reckless, wild behavior".
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While Orexin-A, an agonist, works by binding to receptors in the brain, Belsomra is an antagonist drug: it blocks molecules from binding at those receptors, and can be used to treat symptoms of insomnia, a sleep disorder that can be called the opposite of narcolepsy.
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Jazz Pharmaceuticals PLC: * JAZZ PHARMACEUTICALS ANNOUNCES FDA ACCEPTANCE OF NEW DRUG APPLICATION FOR JZP-258 FOR CATAPLEXY AND EXCESSIVE DAYTIME SLEEPINESS ASSOCIATED WITH NARCOLEPSY * JAZZ PHARMACEUTICALS - PDUFA GOAL DATE FOR AN FDA DECISION FOR JZP-258 IS JULY 21, 2020 Source text for Eikon: Further company coverage:
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I will never know how much of my spiritual experience can be attributed to narcolepsy versus the powers of my own mind, but it seems to me that on that night almost 19 years ago, a miracle and a disorder met at a perfect confluence of science and faith.
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"What's generally said, and it's a very hard thing to prove, is that only about half of people with narcolepsy are actually diagnosed as such," said Dr. Thomas Scammell, a professor of neurology at Harvard Medical School and a physician at Beth Israel Deaconess Medical Center in Boston.
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It's a central nervous system stimulant that treats both ADHD and narcolepsy, but in recent years it's been more in the spotlight because of abuse fears — as college students take it to focus before tests, and eSports athletes use it as a performance-enhancing drug (to sharpen their game-playing skills).
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These, conceivably, symbolize an unvarying actual state of things existing beneath the hyperactive surface of life—not death, exactly, which causes matter to continue doing things, nor what one would care to call life, but a state like narcolepsy, in which just enough energy accumulates and gets expended to maintain immobility.
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The number of people who suffer from insomnia in the US (60 million) is much higher than the number of people who have narcolepsy (200,000), and—excluding the market of college students who want to stay up all night to study for finals—therefore there is much greater demand for insomnia cures.
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Catie Weimer, a record store employee in Salt Lake City who was given a diagnosis of narcolepsy after getting a subsidized marketplace plan last year, said she had joined a group called Utahns Speak Out, which she found on Facebook, as she grew increasingly anxious about the prospect of losing her insurance.
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I went away to college for the first time, and over the course of nine months was diagnosed with narcolepsy, gastroesophageal reflux disease (which may actually be IBS, am still running tests), had one of my worst periods of depression and bad anxiety flare-ups, and gained about 40 pounds because of all of it.
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Within just 15 years of the Cell publication by Mignot and colleagues that linked a loss of orexin to narcolepsy, Merck had received US Food and Drug Administration (FDA) approval for suvorexant (or Belsomra as it's known in the trade), a small molecule capable of getting through the blood--brain barrier and blocking orexin receptors.
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Within just 15 years of the Cell publication by Mignot and colleagues that linked a loss of orexin to narcolepsy, Merck had received US Food and Drug Administration (FDA) approval for suvorexant (or Belsomra as it's known in the trade), a small molecule capable of getting through the blood–brain barrier and blocking orexin receptors.
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"Part of the challenge is because narcolepsy isn't a common disease and because most doctors get very little training in sleep disorders, our concern is that a lot of times, when people go to their primary care doctor, neither the patient nor the doctor may really have an appreciation of what are the right questions to ask to lead to the diagnosis," Scammell said.
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While the episode does feature too much Jackie Jr. (note: any amount of Jackie Jr. is too much Jackie Jr.), it makes up for it by introducing Aaron Arkaway, Janice's boyfriend and Christian songwriting partner, who suffers from narcolepsy and can't keep his eyes open during dinner—but is excited to announce the news that "he is risen" to everyone who enters the Soprano home.
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The duo of John Sterling and Suzyn Waldman is unlike other radio broadcasts in the sense that where one team might employ a wild card—a play-by-play man prone to curlicues or puns or narcolepsy, say, or a benignly sozzled ex-player given to MC Escher-esque digression—the Yankees employ two of the most relentlessly, intensely weird broadcasters in the sport, at the same time.
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