99 Sentences With "most novel" | Random Sentence Generator

Perhaps most novel, they'll learn to challenge traditional gender roles.

At this point, the proposal's most novel element would kick in.

"Most novel arguments crash and burn, but some soar," Professor Gerrard said.

The most novel thing about them is a two-piece rubber tips system.

And what's going on with "augmented virtual reality," one of Abrash's most novel predictions?

One of the most novel parts of his plan involves extending Social Security benefits to caregivers.

The most novel thing about the first episode is its visual style, which transitions across time periods.

And the two wildly different experiences provided by these products may be the most novel aspect of all.

The most novel legal argument stems from a peculiar action Congress took more than a quarter century ago.

The most novel question is whether Apple should be enlisted to give the government access to iPhone data.

Those pings of information are certainly the most novel thing about Lighthouse, but let's start by discussing the hardware.

Mrs Warren's idea is the most novel of many whack-the-rich proposals to have emerged on America's left.

The lesson of the past two presidential elections is that voters want the most novel candidate available to them.

OF ALL the theories to explain the unexpected success of Donald Trump's presidential campaign, this, surely, is the most novel.

For nine years he did so, until he underwent one of the most novel chef transitions we have ever heard of.

Some of the agency's most novel cases came against private equity firms that failed to disclose fees and conflicts of interest.

Some of the most novel case studies and applications of innovation and crowdsourcing are coming from unexpected places: large enterprises and government agencies.

The United States continues to record far and away the most novel coronavirus cases worldwide, with more than 53,000 as of March 31.

"This case is among the most novel and complex ever undertaken by the Department," The DOT said in its final ruling on the matter.

In fact, Skift also recently rounded up the most novel airline patents of 2016, and it is immediately apparent why so many never become reality.

And the most prestigious titles — including Science and Nature — screen for the most novel, most surprising findings that will stand out to scientists across disciplines.

The most novel part of this section is a widget that shows the live feeds from cameras on the sides and rear of the Byton.

Perhaps the most novel part of Bulletin's business model is that the web-born brands will pay rent to appear in its chic IRL enclaves.

It's one of the most novel events put on by a DSA chapter to date, and also a way to help people in a real way.

In fact, most cancers occur because of defects in apoptosis, and most novel cancer therapies are designed to allow cell death to occur as it normally would.

The most novel element in her personal contribution to the body of evidence, so to speak, was the notion of positioning a bump on either side of her temple.

And the company said in October that the most novel thing about the network it took down was an expanded effort to conceal Russian links to the accounts themselves.

The most novel thing about Mr Trump, though, when compared with the fringe figures who preceded him, is that he is the nominee of one of America's two main parties.

So even in its most novel idea, in allowing a truly free world full of diverse towns and characters, Romancing SaGa shoots itself in the foot by limiting its scope.

Turning to shows like Project Runway and Say Yes to the Dress for inspiration, she came up with her most novel item yet: a wedding dress constructed almost entirely from Styrofoam.

The most novel and controversial feature of the IEX exchange is a so-called speed bump that would slow down trading slightly to throw off traders that rely only on speed.

One of the most novel aspects of the business plan is that while the company won't offer anything tied to flimsy evidence, it does include supplements with inconclusive or newly emerging scientific backing.

Shadow of Mordor told only about half of the story they originally envisioned, and its most novel design feature — the "nemesis system" that generates new stories for everyone who plays — was also pared back.

Like most novel drugs, Lynparza is first being tested in the sickest patients — those who have so-called metastatic disease that has spread to other parts of the body and who often have grim survival prospects.

That's not exactly the most novel concept (and Mozilla has often been criticized for diverting its attention from its core competencies), but the built-in encryption and the open-source nature of the tool do make up for that.

They can market their meals on platforms like Instagram to a wider audience, tapping into a "visual obsession with food" that Mr. Doss says rewards the most "novel, spicy and authentic cuisines" that Torontonians can get their hands on.

Perhaps the most novel aspect of the legislation is its proposal that banks with a simple leverage ratio of 10 percent or higher be exempted from a number of regulatory requirements, including Dodd-Frank's heightened standards for larger lenders.

But perhaps the most novel — and disturbing — of Mr. Asiri's plots involved the recruitment of his own brother to become a suicide bomber in a 2009 plan to assassinate Saudi Arabia's crown prince at the time, Mohammed bin Nayef.

Beyoncé and the Dixie Chicks may have been the evening's most novel pairing onstage, but they were nothing compared to the two men who made fast friends backstage: Thomas Rhett and Beyoncé's husband, Jay Z. Afterward, Rhett was giddy with delight.

In part, channels like Soph's seem inevitable — offer everyone in the world a microphone, and offer the biggest rewards to those who get our attention in the most novel ways, and some of your creators are going to break bad.

"The most novel result is the large contribution of alcohol-use disorders to the burden of dementia over the lifespan," said Dr. Michael Schwarzinger, a researcher at the Transitional Health Economics Network in Paris and a leading author of the study.

The most novel aspect of Wood's book is that he shows, convincingly, that the stifling and abhorrent practices of the Islamic State are rooted in Islam itself — not mainstream Islam, but in scriptures and practices that have persisted for centuries.

One by one, the newest, most novel wrestlers were eliminated from the match (except for Braun Strowman, who once again looked like a superstar) and, once again, the unique badness of turgidity and temporariness in the Raw-versus-Smackdown storyline dragged things down.

Despite being built originally for the Nintendo Wii U, Mario Kart 8 Deluxe feels as if it was always meant to demonstrate the Switch's most novel feature: the ability to pop off two controllers and use the tablet as a shared screen.

The Podpal has a zippered divider inside, tie-down straps and a telescoping handle, but its most novel feature is the cradle on top to hold any currently available tablet—either vertically or horizontally—to better entertain you during downtime at the gate.

As an appendage to a holiday however it is probably one of the most novel things to happen to the world festival scene; not in the sense it's a reggae festival, since these happen the world over, but with the idea Tmrw.

Artificial intelligence research is not immune to such structural factors, and in fact, may even be worse given the incredible surge of excitement around AI, which has pushed researchers to find the most novel advances and share them as quickly and as widely as possible.

Then there is Angel McCoughtry, one of the top scorers in the W.N.B.A. At age 30, her body was signaling that it needed a break, so she devised what might be the most novel approach yet by a professional athlete looking to extend a career.

"The most novel thing about Jeuveau is its unique marketing strategy — targeting younger millennials in a fresher way, with emojis, an app, diverse models, and lots of pink," says Lara Devgan, MD, a New York City plastic surgeon and RealSelf chief medical officer who attended the industry event in Cancun.

But back in March, VR itself was the most novel addition to Rock Band VR. If you got past the eye-activated fireworks and motion-tracked guitar, you were still trying to precisely hit sequences of buttons on the right beats, with the occasional creative flourish via effects pedal or whammy bar.

A number of methods of removing space debris were discussed at the conference, although one of the most novel was a detumbler—this method would deploy CubeSats that would attach to tumbling space debris, reduce the tumbling motion before sending the space junk to a disposal orbit at about 50 kilometers up.

When I first spoke about my love of the criminally underappreciated Unexplored on Waypoint Radio a couple of weeks ago, I focused on its most novel aspects: Its ability to foreshadow what will happen in deeper depths of the game's dungeon; its unique, "cyclical" level generation, which alleviates the amount of backtracking you need to do; its simple, yet deliberate combat.

" Royal Jordanian Airlines took perhaps the most novel approach, responding on Twitter in verse (if not quite in metre): Every week a new banTravel to the U.S. since you canWe are now poets because of you sonNo one can ruin our in-flight funWe have good tips for everyone The airline followed up with a tweet outlining "12 things to do on a 12-hour flight with no laptop or tablet", although some, like #9 ("Pretend tray table is a keyboard"), might not be too persuasive, nor another suggesting, "do what we Jordanians do best… Stare at each other!

Its most novel feature was separate smoking rooms for men and women. Additionally, each dressing room was equipped with a shower and telephone.

G. Wells, The Work, Wealth and Happiness of Mankind (London: William Heinemann, 1932), p. 1. he called it "the least finished work . . . because it is the most novel."H.G. Wells, The Work, Wealth and Happiness of Mankind (London: William Heinemann, 1932), p. 26.

Yet in the assessment of A. A. Seyed-Gohrab, 'Persian literary riddles provide us with some of the most novel and intricate metaphors and images in Persian poetry'.A. A. Seyed-Gohrab, Courtly Riddles: Enigmatic Embellishments in Early Persian Poetry (Leiden: Leiden University Press, 2010), p. 64.

A Rubber Band Christmas is a 1996 instrumental Christmas novelty album featuring traditional and popular Christmas songs played entirely on rubber bands, staplers and other office equipment. The album is noted for its comic effects and has been described as one of the "weirdest" and most novel releases of its type.

Don't bring your children." The Film Daily (July 21, 1929): "Here is one of the most novel cartoon subjects ever shown on a screen. Here we have a bunch of skeletons knocking out the laughs on their own bones, and how. They do a xylophone number with one playing the tune on the others spine.

Clark Field was a baseball park in Austin, Texas, used primarily by the University of Texas Longhorns. The field was used from 1928 until 1974. It is considered one of the most novel ballparks ever conceived thanks to its location. There was a limestone cliff in the outfield that created havoc for outfielders and made baseball games exciting.

Perhaps the most novel feature of the M77 is the only one that has not been redesigned, the angled action screw. The front action screw of traditional bolt-action rifles draws the receiver directly down against the stock. The M77 uses an angled screw that draws the action down and to the rear, tightly bedding it against the stock.

But in 1910 Chagovets arrived and immediately applied for funding for improvement of physiology equipment. He got 20,000 golden roubles (appr. $10,000 of that time which with inflation correction means almost $250,000 in modern US dollars) and bought the most novel German equipment: galvanometers, kymograph, rheostats, microscopes, timers etc. He organized modern animal operation clinics taken as the specimen Pavlov's lab.

The most novel part of the 1968 transit plan was the distributor subway system. It was to be routed from a terminal at Harrison and Morgan Streets at the University of Illinois at Chicago. From there, the line was to run north to Adams Street paralleling Morgan Street. At Adams Street the alignment was to turn east, meeting Monroe Street at Peoria Street.

The school's initial goals were to equip their pupils with a broad understanding of literature, languages, ethics, fine arts, as well as science and mathematics. The most novel feature of the curriculum was the organization of literature and history. Forty years later, the school relocated to a building on Cedar Avenue, on the slope of Mount Royal. By then there were approximately 150 girls attending, which included 17 boarders.

The increased optical gain brings some problems due to the possibility of getting more than one returned photon per pulse. The most novel component of the APOLLO system is the integrated array of Single-Photon Avalanche Diodes (SPADs) used in the detector. This technology is needed to deal with multiple photon returns within each pulse. Most single photon detectors suffer from "dead time": they cannot detect a photon if it arrives soon after another.

A creature in its ontogeny may combine heterochronic features in six vectors, although Gould considers that there is some binding with growth and sexual maturation. A creature may, for example, present some neotenic features and retarded development, resulting in new features derived from an original creature only by regulatory genes. Most novel human features (compared to closely related apes) were of this nature, not implying major change in structural genes, as was classically considered.

The Monitor was the most innovative design by virtue of its low freeboard, shallow-draft iron hull, and total dependence on steam power. The riskiest element of its design was its rotating gun turret, something that had not previously been tested by any navy. Ericsson's guarantee of delivery in 100 days proved to be decisive in choosing his design despite the risk involved. The wooden-hulled Galenas most novel feature was her armor of interlocking iron rails.

Millie isn't in love, but agrees to marry him for everyone's sake. Mike mistakenly thinks she's in love with Frank, so he helps Millie get out of the wedding at the last minute. Mike also stumbles onto a hidden speakeasy in the Drake basement which contains the Drake family's valuable first harpsichord and a fully stocked wine cellar. When the place is opened as "Drake's Amsterdam Tavern, New York's most novel nightclub", their financial troubles are over.

In the late 1950s and early 1960s, while living in Mexico City, he wrote and drew his innovative comic strip, Jackys Diary. It began January 11, 1959, continuing until 1961. The Sunday-only strip is regarded by many comics buffs as one of King Features most novel and clever humor strips. In Toonopedia, Don Markstein wrote: > It purported to be the hand-illustrated, hand-written diary of a young boy, > supposedly Mendelsohn himself in his extreme youth.

B was signed by James G. Douglas, C.J. France and Hugh Kennedy and it differed substantially from A only in proposals regarding the Executive.Douglas p81 This difference was intended by Douglas to permit the anti-treaty faction a say in the final proposed constitution before its submission to the British Government. As such it was, according to Douglas, an attempt to ameliorate the pro- and anti-treaty split. Draft C was the most novel of the three.

AllMusic states that in spite of the unusual instrumentation, the tracks are "still recognizable as--and a whole lot sillier than--the original carols." The reviewer concludes that while the 14 tracks "may be too much of a good thing", the release constitutes "easily the most novel holiday novelty album in a long while. It must be heard to be believed." Scott Frampton of CMJ New Music Monthly wrote that the album would have strong appeal to "aficionados of the pop-culturally weird".

A burst of research on viruses of E. histolytica stems from a series of papers published by Diamond et al. from 1972 to 1979. In 1972, they hypothesized two separate polyhedral and filamentous viral strains within E. histolytica that caused cell lysis. Perhaps the most novel observation was that two kinds of viral strains existed, and that within one type of amoeba (strain HB-301) the polyhedral strain had no detrimental effect but led to cell lysis in another (strain HK-9).

Multiflow's computers were arguably the most novel ever to be broadly sold, programmed, and used like conventional computers. (Other novel computers either required novel programming, or represented more incremental steps beyond existing computers.) Along with Cydrome, an attached- VLIW minisupercomputer company that had less commercial success, Multiflow demonstrated that the VLIW design style was practical, a conclusion surprising to many. While still controversial, VLIW has since been a force in high- performance embedded systems, and has been finding slow acceptance in general- purpose computing.

The Amiri typeface draws inspiration from a naskh typeface pioneered by the Bulaq Press (), also called al-Mataabi' al-Amiriya (), in 1905. On the 1905 typeface and of challenges of digitizing Arabic script, Dr. Hosny wrote: "One of the most novel features of the Bulaq typeface is maintaining the æsthetics of Naskh calligraphy while meeting the requirements (and limitations) of typesetting, a balance that is not easily achieved." The Amiri project was supported by Google Web Fonts, TeX Users Group, and donations from users.

Probably the > most novel feature of the decorative scheme, excepting the incandescent > mirrors was the peacock shell utilized by the orchestra. The initial Astor House orchestra had eight members under the direction of "Whitey" Smith. Later the resident Astor Orchestra was directed by Alex Bershadsky, a White Russian émigré,Valentin Vassilievich Fedoulenko and Boris Raymond, Russian Émigré Life in Shanghai (Bancroft Library, 1967):66; Hibbard, Bund, 217. while the orchestra of Ben Williams, the first American orchestra to travel to Shanghai, also played at the Astor House.

Gray accepted that there are many unconscious systems that detect errors, so this on its own does not establish a survival value for consciousness. However, he distinguished consciousness as being multi-modal, and as directing us towards whatever is most novel within several modalities. Gray argued that the brain takes account of plans as to what to do next, plus memories of past regularities, in assessing what is likely to be the next stage of a particular process. These predictions are submitted to a comparator, but still at an unconscious stage.

In 1984 he became the Director of the Center for Environmental Management at Tufts University, and in 1989 he was named the dean of a newly created Environmental Program at the same University. During his tenure this program established the first program in environmental literacy, a partnership between the university and industry. The most novel feature of this program was the incorporation of environmental literacy into the curricula of a broad spectrum of academic programs. Tufts University received the only Presidential Citation for development of this program in 1990.

It was powered by a 70 hp 4-cylinder Argus engine driving a single propeller at the front of the nacelle via a 5:1 reduction gearbox. The engine also drove a pump to maintain pressure in the internal ballonet. The nacelle was a square-section wire- braced wooden structure which had been used in the unsuccessful design of 1902, and carried a pair of rudders at the rear and a pair of biplane elevators. The most novel feature of the design were the tail surfaces, which consisted of elongated tubes inflated with hydrogen.

One of his most novel techniques in the game is the "Off-the-Wall Kick" which allows Guy to bounce off the wall with a jump kick. He wears the kanji embroidered into his shinobi shozoku. His speech and mannerisms are characterized by a stiff formality. In Street Fighter Alpha, Guy's character design was altered slightly, with his jika-tabi replaced by sneakers (a change that was retained when Guy was brought back into the Final Fight series in Final Fight 3), although his fighting style mimics that of his Final Fight counterpart.

This outcast proletariat—perhaps 1.5 billion people today, 2.5 billion by 2030—is the fastest-growing and most novel social class on the planet. By and large, the urban informal working class is not a labor reserve army in the nineteenth-century sense: a backlog of strikebreakers during booms; to be expelled during busts; then reabsorbed again in the next expansion. On the contrary, this is a mass of humanity structurally and biologically redundant to the global accumulation and the corporate matrix. It is ontologically both similar and dissimilar to the historical agency described in the Communist Manifesto.

In 1978, pushed by Berger, she once again trod the boards of the Théâtre des Champs-Élysées where she had auditioned 15 years earlier, starring in a show titled Made in France. The most novel aspect of this show was that, except for the Brazilian drag act Les Étoiles, the members of the orchestra, choir and the dance troupe were exclusively female. In this show, France sang "Maria vai com as outras" the original, Brazilian (Portuguese) version of "Plus haut que moi". In 1979, Gall took part in a new show which remains memorable for many.

A boom in new construction after 1926 created stiff competition for older buildings like the Monadnock. Occupancy declined from 87 percent in 1929 to 55 percent in 1937 and the building began to lose money. In 1938, building manager Graham Aldis (Owen's nephew) announced what the Chicago Daily Tribune called "the city's largest and most novel modernization job" in a move toward halting the destruction of Chicago's aging skyscrapers. Rejecting the term "modernization", Aldis called his plan "progressive styling", which he believed would revolutionize the way building maintenance was done to preserve millions of dollars worth of buildings that would otherwise be destroyed.

With the lake out of their hands, Leonard and Holt decided to build another, Emerald Lake No. 2 or Upper Emerald Lake. It was to be the centerpiece of the 3,000-resident community the Highlands of Emerald Lake. By summer 1927 they had built the lake by damming a creek and had created a beach, water slide, diving platforms and a playground with "equipment of the most novel design." The lake's clubhouse was what is now the residence at Lakeview and Edgecliff; (it was owned and restored by the Kenneth McBain family from 1964 until 2012); a structure at Lakeview and Jefferson is recalled as a roadhouse.

A very important intelligence item in the 1960-70s was the characteristics of Soviet radars, particularly those systems associated with their defense systems against bombers and ballistic missiles. U-2 and A-12 aircraft flew special missions to gather this information. The most novel collection means was through signals from Soviet radars reflected by the moon; a facility for such collection was set up by the CIA at Stanford University in 1966. Shortly after he became the Director of the DS&T;, Wheelon had proposed using a geosynchronous satellite to relay very-high and ultra-high frequency (VHF and UHF) telemetry signals from Soviet test sites to CIA control stations.

Generally, acute myeloid leukemia is treated using chemotherapy consisting of an induction phase and consolidation phase (Dohner et al., 2009). Patients may also consider hematopoietic stem cell transplantation as a second mode of tackling the cancer. The most novel research is being done in tyrosine kinase inhibitors; however M2 acute myeloid leukemia treatment research involves molecules that inhibit the fusion oncoprotein AML1-ETO. Therefore, in terms of M2 subtype acute myeloid leukemia, the most prominent target is the abnormal AML1-ETO fusion protein. Similarly, chronic myeloid leukemia (CML) is comparable to acute myeloid leukemia M2 because it also forms a fusion oncoprotein – BCR-Abl.

One of Rosary Academy's most novel traditions is that of "Red and Gold", an annual school-wide, student-run musical competition. From January to March, the students are divided into two teams (the Red and Gold teams) which each have student captains in the categories of script, drama, choral, dance, drill, props, publicity, media, fashion, historian, house manager, and stage tech, as well as two overall producers. A neutral ("White") team also participates, made up of ASB members as well as representatives from the junior and senior classes. The White team helps to facilitate the logistical portion of the production and announces the winner at the end of the last performance.

" Marvin Olasky of World (magazine) called Survivors "...not as well-written as some articles Rawles has penned" Rawles uses an unusual contemporaneous approach to writing sequels. Rather than the traditional formula of following the same group of characters farther into the future, he instead uses a novel sequence method that portrays different characters in different geographic regions, but in the same near-future timeframe as in Patriots. In his Introductory note to Survivors, Rawles stated: "Unlike most novel sequels, the storyline of Survivors is contemporaneous with the events described in my previously- published novel Patriots. Thus, there is no need to read it first (or subsequently), but you'll likely find it entertaining.

Perhaps most novel was the suggestion of a "hybrid" world's fair composed of a BIE-sanctioned "recognized" exposition, a horticultural exposition, and a housing ("Habitat 2017") exposition. This was apparently due to the fact that in 2017, only a very small "recognized" expo would be permitted by the Bureau of International Expositions (BIE)—the Paris- based body which governs world's fairs. By holding three smaller expos simultaneously, a city could ostensibly stage a relatively sizeable exposition with a greater degree of flexibility, yet less cost (apparently), than a single larger ("universal") expo such as Expo 67. The proposal also states that the housing and horticultural aspects would be jointly financed through public-private partnerships.

The most novel methodological contribution across many of these works is that they employ Q methodology, an inductive approach to the study of human subjectivity developed in cognitive psychology, her work being one of the few applications of Q methodology in Political Science. In recent years, Zechmeister has examined public opinion in the wake of natural disasters. Building off surveys conducted following the Chilean and Haitian earthquakes in 2010, Zechmeister explores in a set of papers the effect material damage and loss has on democratic attitudes and interpersonal trust. In a paper coauthored with Ryan Carlin and Gregory Love, she shows disaster victims in Chile often become less tolerant and supportive of democracy while also becoming more civically engaged.

Parkin (1979a) Arguably, the most novel aspect of Parkin's contribution was that he wanted to define classes in terms of their closure strategies, as opposed to defining class with reference to some structure of positions. The bourgeoisie could be identified, he held, by their reliance on exclusionary closure, as opposed to, say, their ownership of the means of production. Similarly, a subordinate class would be identified by their reliance on usurpationary closure: :the familiar distinction between bourgeoisie and proletariat, in its classic as well as its modern guise, may be conceived of as an expression of conflict between classes defined not specifically in relation to their place in the productive process but in relation to their prevalent modes of closure, exclusion and usurpation, respectively.Parkin (1979a), p. 46.

Machiavelli shows repeatedly that he saw religion as man-made, and that the value of religion lies in its contribution to social order and the rules of morality must be dispensed with if security requires it. In The Prince, the Discourses, and in the Life of Castruccio Castracani, he describes "prophets", as he calls them, like Moses, Romulus, Cyrus the Great, and Theseus (he treated pagan and Christian patriarchs in the same way) as the greatest of new princes, the glorious and brutal founders of the most novel innovations in politics, and men whom Machiavelli assures us have always used a large amount of armed force and murder against their own people.Especially in the Discourses III.30, but also The Prince Chap.

At the Butterley works he applied the principle of a rapid rotation of the mould in casting iron pipes, and incurred great expense in securing a patent, only to find that a foreigner, who used the same process in casting terra cotta, had recited in his specifications that the same mode might be applied to metals. The most novel and ingenious of his inventions was the walking machine called the Steam Horse, which he made at Butterley in 1813 for use on the company's tramway at Crich. A second one was built for the Newbottle colliery, which worked with a load up a gradient of 1 in 36 during all the winter of 1814. Early in 1815, through some carelessness, this machine exploded and killed thirteen persons.

IUBMB Life is the flagship journal of the International Union of Biochemistry and Molecular Biology and is devoted to the rapid publication of the most novel and significant original research articles, reviews, and hypotheses in the broadly defined fields of biochemistry, molecular biology, cell biology, and molecular medicine. The journal publishes interdisciplinary, basic to translational research and covers all fields in the life science at every level of organization: Research communications are original research articles that present new findings of unusually high importance, which provide major new functional insights in biology. Critical Reviews are short, concise, and sharply focused reviews of current hot topics in the biological sciences. Critical Reviews and Hypotheses Papers make new specialized areas highly accessible to all scientists and develop novel insights and approaches for future research.

The most novel part of the conception of the exchange design was the use of pulse amplitude modulation and time division multiplex techniques for the transmission of up to one hundred conversations over a common channel, which was well ahead of its time. This technique would eventually be used in System X and other digital exchanges as technology caught up. Another interesting feature of the installation was the use of time-sharing in the setting-up of the calls and in their control, which was something that all subsequent digital exchange design would follow. At the time in Strowger exchanges ranks of selectors were interconnected by means of a complex trunking system dictated by the method of setting up the calls and by the need to economise in the total number of switching points.

Most novel drug candidates (NCEs) fail during drug development, either because they have unacceptable toxicity or because they simply do not prove efficacy on the targeted disease, as shown in Phase II–III clinical trials. Critical reviews of drug development programs indicate that Phase II–III clinical trials fail due mainly to unknown toxic side effects (50% failure of Phase II cardiology trials), and because of inadequate financing, trial design weaknesses, or poor trial execution. A study covering clinical research in the 1980–90s found that only 21.5% of drug candidates that started Phase I trials were eventually approved for marketing. During 2006–15, the success rate of obtaining approval from Phase I to successful Phase III trials was under 10% on average, and 16% specifically for vaccines.

Fluckiger called the book "easily the most provocative work on sexuality to have appeared in a long time" and credited Tripp with offering a powerful challenge to established views about homosexuality and showing command of a range of data from many fields. He maintained that Tripp offered the most novel account of the way in which behavioral expression communicates internal states since the naturalist Charles Darwin's The Expression of the Emotions in Man and Animals (1872), but considered his most original contribution to be his explanation of how erotic feeling depends on "resistance". The Atlantic Monthly described the book as "well-written", "authoritative", and "indispensable" for readers with a serious interest in homosexuality. It stated that Tripp contradicted most generally held beliefs about the origins of homosexuality with "an impressive mass of evidence".

It was then examined by an appropriate Sardinian committee and the Reale Udienza of Sardinia. The result was a confection of Sardinian and mainland sources, creating a law which was both traditional and novel.. G. Manno, Biografia di S. A. R. il duca del Genevese poscia re C. F., in Note sarde e ricordi, Torino 1868, p. 288 The most novel changes relate to penal law: the abolition of the giudatico (impunity for criminals who had arrested other criminals) and the esemplarità (cruel extensions of the death penalty, like quartering the corpse and scattering the ashes); restrictions on the imposition of the death penalty; affirmation of the principle that the punishment should fit the crime; and the distinction between attempted crimes and crimes actually committed.C. Sole,La Sardegna di Carlo Felice e il problema della terra, Cagliari 1967 p.

Attack roles were generally assigned to dedicated ground-attack aircraft such as the Sukhoi Su-25 and the A-10 Thunderbolt II. A typical US Air Force fighter wing of the period might contain a mix of one air superiority squadron (F-15C), one strike fighter squadron (F-15E), and two multirole fighter squadrons (F-16C). Perhaps the most novel technology introduced for combat aircraft was stealth, which involves the use of special "low-observable" (L-O) materials and design techniques to reduce the susceptibility of an aircraft to detection by the enemy's sensor systems, particularly radars. The first stealth aircraft introduced were the Lockheed F-117 Nighthawk attack aircraft (introduced in 1983) and the Northrop Grumman B-2 Spirit bomber (first flew in 1989). Although no stealthy fighters per se appeared among the fourth generation, some radar-absorbent coatings and other L-O treatments developed for these programs are reported to have been subsequently applied to fourth-generation fighters.

Sōten Kōro's story is based loosely on the events taking place in Three Kingdoms period of China during the life of the last Chancellor of the Eastern Han Dynasty, Cao Cao (155 – March 15, 220), who also serves as the main character. The Three Kingdoms period has been a popular theme in Japanese manga for decades, but Sōten Kōro differs greatly from most of the others on several points. One significant difference is its highly positive portrayal of its main character, Cao Cao, who is traditionally the antagonist in not only Japanese manga, but also most novel versions of the Three Kingdoms period, including the original 14th-century version, Romance of the Three Kingdoms by Luo Guanzhong. Another significant difference from others is that the storyline primarily uses the original historical account of the era, Records of Three Kingdoms by Chen Shou, as a reference rather than the aforementioned Romance of the Three Kingdoms novel.

Reenactment of an early imperial legionary shield array According to Polybius, the scutum gave Roman soldiers an edge over their Carthaginian enemies during the Punic Wars: "Their arms also give the men both protection and confidence, which they owed to the size of the shield." The Roman writer Suetonius recorded anecdotes of the heroic centurion Cassius Scaeva and legionary Gaius Acilius who fought under Caesar in the Battle of Dyrrachium and the battle of Massilia, respectively: The Roman writer Cassius Dio in his Roman History described Roman against Roman in the Battle of Philippi: "For a long time there was pushing of shield against shield and thrusting with the sword, as they were at first cautiously looking for a chance to wound others without being wounded themselves." The shape of the scutum allowed packed formations of legionaries to overlap their shields to provide an effective barrier against projectiles. The most novel (and specialised, for it afforded negligible protection against other attacks) use was the testudo (Latin for "tortoise"), which added legionaries holding shields from above to protect against descending projectiles (such as arrows, spears, or objects thrown by defenders on walls).

Perhaps most novel, they'll learn to challenge traditional gender roles. from Vice
At this point, the proposal's most novel element would kick in. from The New York Times
"Most novel arguments crash and burn, but some soar," Professor Gerrard said. from The New York Times
The most novel thing about them is a two-piece rubber tips system. from The Verge
And what's going on with "augmented virtual reality," one of Abrash's most novel predictions? from The Verge
One of the most novel parts of his plan involves extending Social Security benefits to caregivers. from Vox
The most novel thing about the first episode is its visual style, which transitions across time periods. from The Verge
And the two wildly different experiences provided by these products may be the most novel aspect of all. from Refinery 29
The most novel legal argument stems from a peculiar action Congress took more than a quarter century ago. from The Hill
The most novel question is whether Apple should be enlisted to give the government access to iPhone data. from The New York Times
Those pings of information are certainly the most novel thing about Lighthouse, but let's start by discussing the hardware. from The Verge
Mrs Warren's idea is the most novel of many whack-the-rich proposals to have emerged on America's left. from Economist
The lesson of the past two presidential elections is that voters want the most novel candidate available to them. from Economist
OF ALL the theories to explain the unexpected success of Donald Trump's presidential campaign, this, surely, is the most novel. from Economist
For nine years he did so, until he underwent one of the most novel chef transitions we have ever heard of. from Vice
Some of the agency's most novel cases came against private equity firms that failed to disclose fees and conflicts of interest. from The New York Times
Some of the most novel case studies and applications of innovation and crowdsourcing are coming from unexpected places: large enterprises and government agencies. from TechCrunch
The United States continues to record far and away the most novel coronavirus cases worldwide, with more than 53,000 as of March 31. from Vox
"This case is among the most novel and complex ever undertaken by the Department," The DOT said in its final ruling on the matter. from Business Insider
In fact, Skift also recently rounded up the most novel airline patents of 2016, and it is immediately apparent why so many never become reality. from Economist
And the most prestigious titles — including Science and Nature — screen for the most novel, most surprising findings that will stand out to scientists across disciplines. from Buzzfeed News
The most novel part of this section is a widget that shows the live feeds from cameras on the sides and rear of the Byton. from The Verge
Perhaps the most novel part of Bulletin's business model is that the web-born brands will pay rent to appear in its chic IRL enclaves. from Mashable
It's one of the most novel events put on by a DSA chapter to date, and also a way to help people in a real way. from Vice
In fact, most cancers occur because of defects in apoptosis, and most novel cancer therapies are designed to allow cell death to occur as it normally would. from The New York Times
The most novel element in her personal contribution to the body of evidence, so to speak, was the notion of positioning a bump on either side of her temple. from Hyperallergic
And the company said in October that the most novel thing about the network it took down was an expanded effort to conceal Russian links to the accounts themselves. from Wired
The most novel thing about Mr Trump, though, when compared with the fringe figures who preceded him, is that he is the nominee of one of America's two main parties. from Economist
So even in its most novel idea, in allowing a truly free world full of diverse towns and characters, Romancing SaGa shoots itself in the foot by limiting its scope. from Vice
Turning to shows like Project Runway and Say Yes to the Dress for inspiration, she came up with her most novel item yet: a wedding dress constructed almost entirely from Styrofoam. from People
The most novel and controversial feature of the IEX exchange is a so-called speed bump that would slow down trading slightly to throw off traders that rely only on speed. from The New York Times
One of the most novel aspects of the business plan is that while the company won't offer anything tied to flimsy evidence, it does include supplements with inconclusive or newly emerging scientific backing. from Mashable
Shadow of Mordor told only about half of the story they originally envisioned, and its most novel design feature — the "nemesis system" that generates new stories for everyone who plays — was also pared back. from The Verge
Like most novel drugs, Lynparza is first being tested in the sickest patients — those who have so-called metastatic disease that has spread to other parts of the body and who often have grim survival prospects. from CNBC
That's not exactly the most novel concept (and Mozilla has often been criticized for diverting its attention from its core competencies), but the built-in encryption and the open-source nature of the tool do make up for that. from TechCrunch
They can market their meals on platforms like Instagram to a wider audience, tapping into a "visual obsession with food" that Mr. Doss says rewards the most "novel, spicy and authentic cuisines" that Torontonians can get their hands on. from The New York Times
Perhaps the most novel aspect of the legislation is its proposal that banks with a simple leverage ratio of 10 percent or higher be exempted from a number of regulatory requirements, including Dodd-Frank's heightened standards for larger lenders. from The New York Times
But perhaps the most novel — and disturbing — of Mr. Asiri's plots involved the recruitment of his own brother to become a suicide bomber in a 2009 plan to assassinate Saudi Arabia's crown prince at the time, Mohammed bin Nayef. from The New York Times
Beyoncé and the Dixie Chicks may have been the evening's most novel pairing onstage, but they were nothing compared to the two men who made fast friends backstage: Thomas Rhett and Beyoncé's husband, Jay Z. Afterward, Rhett was giddy with delight. from People
In part, channels like Soph's seem inevitable — offer everyone in the world a microphone, and offer the biggest rewards to those who get our attention in the most novel ways, and some of your creators are going to break bad. from The Verge
"The most novel result is the large contribution of alcohol-use disorders to the burden of dementia over the lifespan," said Dr. Michael Schwarzinger, a researcher at the Transitional Health Economics Network in Paris and a leading author of the study. from CNN
The most novel aspect of Wood's book is that he shows, convincingly, that the stifling and abhorrent practices of the Islamic State are rooted in Islam itself — not mainstream Islam, but in scriptures and practices that have persisted for centuries. from The New York Times
One by one, the newest, most novel wrestlers were eliminated from the match (except for Braun Strowman, who once again looked like a superstar) and, once again, the unique badness of turgidity and temporariness in the Raw-versus-Smackdown storyline dragged things down. from Vice
Despite being built originally for the Nintendo Wii U, Mario Kart 8 Deluxe feels as if it was always meant to demonstrate the Switch's most novel feature: the ability to pop off two controllers and use the tablet as a shared screen. from The Verge
The Podpal has a zippered divider inside, tie-down straps and a telescoping handle, but its most novel feature is the cradle on top to hold any currently available tablet—either vertically or horizontally—to better entertain you during downtime at the gate. from People
As an appendage to a holiday however it is probably one of the most novel things to happen to the world festival scene; not in the sense it's a reggae festival, since these happen the world over, but with the idea Tmrw. from Vice
Artificial intelligence research is not immune to such structural factors, and in fact, may even be worse given the incredible surge of excitement around AI, which has pushed researchers to find the most novel advances and share them as quickly and as widely as possible. from TechCrunch
Then there is Angel McCoughtry, one of the top scorers in the W.N.B.A. At age 30, her body was signaling that it needed a break, so she devised what might be the most novel approach yet by a professional athlete looking to extend a career. from The New York Times
"The most novel thing about Jeuveau is its unique marketing strategy — targeting younger millennials in a fresher way, with emojis, an app, diverse models, and lots of pink," says Lara Devgan, MD, a New York City plastic surgeon and RealSelf chief medical officer who attended the industry event in Cancun. from Refinery 29
But back in March, VR itself was the most novel addition to Rock Band VR. If you got past the eye-activated fireworks and motion-tracked guitar, you were still trying to precisely hit sequences of buttons on the right beats, with the occasional creative flourish via effects pedal or whammy bar. from The Verge
A number of methods of removing space debris were discussed at the conference, although one of the most novel was a detumbler—this method would deploy CubeSats that would attach to tumbling space debris, reduce the tumbling motion before sending the space junk to a disposal orbit at about 50 kilometers up. from Vice
When I first spoke about my love of the criminally underappreciated Unexplored on Waypoint Radio a couple of weeks ago, I focused on its most novel aspects: Its ability to foreshadow what will happen in deeper depths of the game's dungeon; its unique, "cyclical" level generation, which alleviates the amount of backtracking you need to do; its simple, yet deliberate combat. from Vice
" Royal Jordanian Airlines took perhaps the most novel approach, responding on Twitter in verse (if not quite in metre): Every week a new banTravel to the U.S. since you canWe are now poets because of you sonNo one can ruin our in-flight funWe have good tips for everyone The airline followed up with a tweet outlining "12 things to do on a 12-hour flight with no laptop or tablet", although some, like #9 ("Pretend tray table is a keyboard"), might not be too persuasive, nor another suggesting, "do what we Jordanians do best… Stare at each other! from Economist
Its most novel feature was separate smoking rooms for men and women. Additionally, each dressing room was equipped with a shower and telephone.
G. Wells, The Work, Wealth and Happiness of Mankind (London: William Heinemann, 1932), p. 1. he called it "the least finished work . . . because it is the most novel."H.G. Wells, The Work, Wealth and Happiness of Mankind (London: William Heinemann, 1932), p. 26.
Yet in the assessment of A. A. Seyed-Gohrab, 'Persian literary riddles provide us with some of the most novel and intricate metaphors and images in Persian poetry'.A. A. Seyed-Gohrab, Courtly Riddles: Enigmatic Embellishments in Early Persian Poetry (Leiden: Leiden University Press, 2010), p. 64.
A Rubber Band Christmas is a 1996 instrumental Christmas novelty album featuring traditional and popular Christmas songs played entirely on rubber bands, staplers and other office equipment. The album is noted for its comic effects and has been described as one of the "weirdest" and most novel releases of its type.
Don't bring your children." The Film Daily (July 21, 1929): "Here is one of the most novel cartoon subjects ever shown on a screen. Here we have a bunch of skeletons knocking out the laughs on their own bones, and how. They do a xylophone number with one playing the tune on the others spine.
Clark Field was a baseball park in Austin, Texas, used primarily by the University of Texas Longhorns. The field was used from 1928 until 1974. It is considered one of the most novel ballparks ever conceived thanks to its location. There was a limestone cliff in the outfield that created havoc for outfielders and made baseball games exciting.
Perhaps the most novel feature of the M77 is the only one that has not been redesigned, the angled action screw. The front action screw of traditional bolt-action rifles draws the receiver directly down against the stock. The M77 uses an angled screw that draws the action down and to the rear, tightly bedding it against the stock.
But in 1910 Chagovets arrived and immediately applied for funding for improvement of physiology equipment. He got 20,000 golden roubles (appr. $10,000 of that time which with inflation correction means almost $250,000 in modern US dollars) and bought the most novel German equipment: galvanometers, kymograph, rheostats, microscopes, timers etc. He organized modern animal operation clinics taken as the specimen Pavlov's lab.
The most novel part of the 1968 transit plan was the distributor subway system. It was to be routed from a terminal at Harrison and Morgan Streets at the University of Illinois at Chicago. From there, the line was to run north to Adams Street paralleling Morgan Street. At Adams Street the alignment was to turn east, meeting Monroe Street at Peoria Street.
The school's initial goals were to equip their pupils with a broad understanding of literature, languages, ethics, fine arts, as well as science and mathematics. The most novel feature of the curriculum was the organization of literature and history. Forty years later, the school relocated to a building on Cedar Avenue, on the slope of Mount Royal. By then there were approximately 150 girls attending, which included 17 boarders.
The increased optical gain brings some problems due to the possibility of getting more than one returned photon per pulse. The most novel component of the APOLLO system is the integrated array of Single-Photon Avalanche Diodes (SPADs) used in the detector. This technology is needed to deal with multiple photon returns within each pulse. Most single photon detectors suffer from "dead time": they cannot detect a photon if it arrives soon after another.
A creature in its ontogeny may combine heterochronic features in six vectors, although Gould considers that there is some binding with growth and sexual maturation. A creature may, for example, present some neotenic features and retarded development, resulting in new features derived from an original creature only by regulatory genes. Most novel human features (compared to closely related apes) were of this nature, not implying major change in structural genes, as was classically considered.
The Monitor was the most innovative design by virtue of its low freeboard, shallow-draft iron hull, and total dependence on steam power. The riskiest element of its design was its rotating gun turret, something that had not previously been tested by any navy. Ericsson's guarantee of delivery in 100 days proved to be decisive in choosing his design despite the risk involved. The wooden-hulled Galenas most novel feature was her armor of interlocking iron rails.
Millie isn't in love, but agrees to marry him for everyone's sake. Mike mistakenly thinks she's in love with Frank, so he helps Millie get out of the wedding at the last minute. Mike also stumbles onto a hidden speakeasy in the Drake basement which contains the Drake family's valuable first harpsichord and a fully stocked wine cellar. When the place is opened as "Drake's Amsterdam Tavern, New York's most novel nightclub", their financial troubles are over.
In the late 1950s and early 1960s, while living in Mexico City, he wrote and drew his innovative comic strip, Jackys Diary. It began January 11, 1959, continuing until 1961. The Sunday-only strip is regarded by many comics buffs as one of King Features most novel and clever humor strips. In Toonopedia, Don Markstein wrote: > It purported to be the hand-illustrated, hand-written diary of a young boy, > supposedly Mendelsohn himself in his extreme youth.
B was signed by James G. Douglas, C.J. France and Hugh Kennedy and it differed substantially from A only in proposals regarding the Executive.Douglas p81 This difference was intended by Douglas to permit the anti-treaty faction a say in the final proposed constitution before its submission to the British Government. As such it was, according to Douglas, an attempt to ameliorate the pro- and anti-treaty split. Draft C was the most novel of the three.
AllMusic states that in spite of the unusual instrumentation, the tracks are "still recognizable as--and a whole lot sillier than--the original carols." The reviewer concludes that while the 14 tracks "may be too much of a good thing", the release constitutes "easily the most novel holiday novelty album in a long while. It must be heard to be believed." Scott Frampton of CMJ New Music Monthly wrote that the album would have strong appeal to "aficionados of the pop-culturally weird".
A burst of research on viruses of E. histolytica stems from a series of papers published by Diamond et al. from 1972 to 1979. In 1972, they hypothesized two separate polyhedral and filamentous viral strains within E. histolytica that caused cell lysis. Perhaps the most novel observation was that two kinds of viral strains existed, and that within one type of amoeba (strain HB-301) the polyhedral strain had no detrimental effect but led to cell lysis in another (strain HK-9).
Multiflow's computers were arguably the most novel ever to be broadly sold, programmed, and used like conventional computers. (Other novel computers either required novel programming, or represented more incremental steps beyond existing computers.) Along with Cydrome, an attached- VLIW minisupercomputer company that had less commercial success, Multiflow demonstrated that the VLIW design style was practical, a conclusion surprising to many. While still controversial, VLIW has since been a force in high- performance embedded systems, and has been finding slow acceptance in general- purpose computing.
The Amiri typeface draws inspiration from a naskh typeface pioneered by the Bulaq Press (), also called al-Mataabi' al-Amiriya (), in 1905. On the 1905 typeface and of challenges of digitizing Arabic script, Dr. Hosny wrote: "One of the most novel features of the Bulaq typeface is maintaining the æsthetics of Naskh calligraphy while meeting the requirements (and limitations) of typesetting, a balance that is not easily achieved." The Amiri project was supported by Google Web Fonts, TeX Users Group, and donations from users.
Probably the > most novel feature of the decorative scheme, excepting the incandescent > mirrors was the peacock shell utilized by the orchestra. The initial Astor House orchestra had eight members under the direction of "Whitey" Smith. Later the resident Astor Orchestra was directed by Alex Bershadsky, a White Russian émigré,Valentin Vassilievich Fedoulenko and Boris Raymond, Russian Émigré Life in Shanghai (Bancroft Library, 1967):66; Hibbard, Bund, 217. while the orchestra of Ben Williams, the first American orchestra to travel to Shanghai, also played at the Astor House.
Gray accepted that there are many unconscious systems that detect errors, so this on its own does not establish a survival value for consciousness. However, he distinguished consciousness as being multi-modal, and as directing us towards whatever is most novel within several modalities. Gray argued that the brain takes account of plans as to what to do next, plus memories of past regularities, in assessing what is likely to be the next stage of a particular process. These predictions are submitted to a comparator, but still at an unconscious stage.
In 1984 he became the Director of the Center for Environmental Management at Tufts University, and in 1989 he was named the dean of a newly created Environmental Program at the same University. During his tenure this program established the first program in environmental literacy, a partnership between the university and industry. The most novel feature of this program was the incorporation of environmental literacy into the curricula of a broad spectrum of academic programs. Tufts University received the only Presidential Citation for development of this program in 1990.
It was powered by a 70 hp 4-cylinder Argus engine driving a single propeller at the front of the nacelle via a 5:1 reduction gearbox. The engine also drove a pump to maintain pressure in the internal ballonet. The nacelle was a square-section wire- braced wooden structure which had been used in the unsuccessful design of 1902, and carried a pair of rudders at the rear and a pair of biplane elevators. The most novel feature of the design were the tail surfaces, which consisted of elongated tubes inflated with hydrogen.
One of his most novel techniques in the game is the "Off-the-Wall Kick" which allows Guy to bounce off the wall with a jump kick. He wears the kanji embroidered into his shinobi shozoku. His speech and mannerisms are characterized by a stiff formality. In Street Fighter Alpha, Guy's character design was altered slightly, with his jika-tabi replaced by sneakers (a change that was retained when Guy was brought back into the Final Fight series in Final Fight 3), although his fighting style mimics that of his Final Fight counterpart.
This outcast proletariat—perhaps 1.5 billion people today, 2.5 billion by 2030—is the fastest-growing and most novel social class on the planet. By and large, the urban informal working class is not a labor reserve army in the nineteenth-century sense: a backlog of strikebreakers during booms; to be expelled during busts; then reabsorbed again in the next expansion. On the contrary, this is a mass of humanity structurally and biologically redundant to the global accumulation and the corporate matrix. It is ontologically both similar and dissimilar to the historical agency described in the Communist Manifesto.
In 1978, pushed by Berger, she once again trod the boards of the Théâtre des Champs-Élysées where she had auditioned 15 years earlier, starring in a show titled Made in France. The most novel aspect of this show was that, except for the Brazilian drag act Les Étoiles, the members of the orchestra, choir and the dance troupe were exclusively female. In this show, France sang "Maria vai com as outras" the original, Brazilian (Portuguese) version of "Plus haut que moi". In 1979, Gall took part in a new show which remains memorable for many.
A boom in new construction after 1926 created stiff competition for older buildings like the Monadnock. Occupancy declined from 87 percent in 1929 to 55 percent in 1937 and the building began to lose money. In 1938, building manager Graham Aldis (Owen's nephew) announced what the Chicago Daily Tribune called "the city's largest and most novel modernization job" in a move toward halting the destruction of Chicago's aging skyscrapers. Rejecting the term "modernization", Aldis called his plan "progressive styling", which he believed would revolutionize the way building maintenance was done to preserve millions of dollars worth of buildings that would otherwise be destroyed.
With the lake out of their hands, Leonard and Holt decided to build another, Emerald Lake No. 2 or Upper Emerald Lake. It was to be the centerpiece of the 3,000-resident community the Highlands of Emerald Lake. By summer 1927 they had built the lake by damming a creek and had created a beach, water slide, diving platforms and a playground with "equipment of the most novel design." The lake's clubhouse was what is now the residence at Lakeview and Edgecliff; (it was owned and restored by the Kenneth McBain family from 1964 until 2012); a structure at Lakeview and Jefferson is recalled as a roadhouse.
A very important intelligence item in the 1960-70s was the characteristics of Soviet radars, particularly those systems associated with their defense systems against bombers and ballistic missiles. U-2 and A-12 aircraft flew special missions to gather this information. The most novel collection means was through signals from Soviet radars reflected by the moon; a facility for such collection was set up by the CIA at Stanford University in 1966. Shortly after he became the Director of the DS&T;, Wheelon had proposed using a geosynchronous satellite to relay very-high and ultra-high frequency (VHF and UHF) telemetry signals from Soviet test sites to CIA control stations.
Generally, acute myeloid leukemia is treated using chemotherapy consisting of an induction phase and consolidation phase (Dohner et al., 2009). Patients may also consider hematopoietic stem cell transplantation as a second mode of tackling the cancer. The most novel research is being done in tyrosine kinase inhibitors; however M2 acute myeloid leukemia treatment research involves molecules that inhibit the fusion oncoprotein AML1-ETO. Therefore, in terms of M2 subtype acute myeloid leukemia, the most prominent target is the abnormal AML1-ETO fusion protein. Similarly, chronic myeloid leukemia (CML) is comparable to acute myeloid leukemia M2 because it also forms a fusion oncoprotein – BCR-Abl.
One of Rosary Academy's most novel traditions is that of "Red and Gold", an annual school-wide, student-run musical competition. From January to March, the students are divided into two teams (the Red and Gold teams) which each have student captains in the categories of script, drama, choral, dance, drill, props, publicity, media, fashion, historian, house manager, and stage tech, as well as two overall producers. A neutral ("White") team also participates, made up of ASB members as well as representatives from the junior and senior classes. The White team helps to facilitate the logistical portion of the production and announces the winner at the end of the last performance.
" Marvin Olasky of World (magazine) called Survivors "...not as well-written as some articles Rawles has penned" Rawles uses an unusual contemporaneous approach to writing sequels. Rather than the traditional formula of following the same group of characters farther into the future, he instead uses a novel sequence method that portrays different characters in different geographic regions, but in the same near-future timeframe as in Patriots. In his Introductory note to Survivors, Rawles stated: "Unlike most novel sequels, the storyline of Survivors is contemporaneous with the events described in my previously- published novel Patriots. Thus, there is no need to read it first (or subsequently), but you'll likely find it entertaining.
Perhaps most novel was the suggestion of a "hybrid" world's fair composed of a BIE-sanctioned "recognized" exposition, a horticultural exposition, and a housing ("Habitat 2017") exposition. This was apparently due to the fact that in 2017, only a very small "recognized" expo would be permitted by the Bureau of International Expositions (BIE)—the Paris- based body which governs world's fairs. By holding three smaller expos simultaneously, a city could ostensibly stage a relatively sizeable exposition with a greater degree of flexibility, yet less cost (apparently), than a single larger ("universal") expo such as Expo 67. The proposal also states that the housing and horticultural aspects would be jointly financed through public-private partnerships.
The most novel methodological contribution across many of these works is that they employ Q methodology, an inductive approach to the study of human subjectivity developed in cognitive psychology, her work being one of the few applications of Q methodology in Political Science. In recent years, Zechmeister has examined public opinion in the wake of natural disasters. Building off surveys conducted following the Chilean and Haitian earthquakes in 2010, Zechmeister explores in a set of papers the effect material damage and loss has on democratic attitudes and interpersonal trust. In a paper coauthored with Ryan Carlin and Gregory Love, she shows disaster victims in Chile often become less tolerant and supportive of democracy while also becoming more civically engaged.
Parkin (1979a) Arguably, the most novel aspect of Parkin's contribution was that he wanted to define classes in terms of their closure strategies, as opposed to defining class with reference to some structure of positions. The bourgeoisie could be identified, he held, by their reliance on exclusionary closure, as opposed to, say, their ownership of the means of production. Similarly, a subordinate class would be identified by their reliance on usurpationary closure: :the familiar distinction between bourgeoisie and proletariat, in its classic as well as its modern guise, may be conceived of as an expression of conflict between classes defined not specifically in relation to their place in the productive process but in relation to their prevalent modes of closure, exclusion and usurpation, respectively.Parkin (1979a), p. 46.
Machiavelli shows repeatedly that he saw religion as man-made, and that the value of religion lies in its contribution to social order and the rules of morality must be dispensed with if security requires it. In The Prince, the Discourses, and in the Life of Castruccio Castracani, he describes "prophets", as he calls them, like Moses, Romulus, Cyrus the Great, and Theseus (he treated pagan and Christian patriarchs in the same way) as the greatest of new princes, the glorious and brutal founders of the most novel innovations in politics, and men whom Machiavelli assures us have always used a large amount of armed force and murder against their own people.Especially in the Discourses III.30, but also The Prince Chap.
At the Butterley works he applied the principle of a rapid rotation of the mould in casting iron pipes, and incurred great expense in securing a patent, only to find that a foreigner, who used the same process in casting terra cotta, had recited in his specifications that the same mode might be applied to metals. The most novel and ingenious of his inventions was the walking machine called the Steam Horse, which he made at Butterley in 1813 for use on the company's tramway at Crich. A second one was built for the Newbottle colliery, which worked with a load up a gradient of 1 in 36 during all the winter of 1814. Early in 1815, through some carelessness, this machine exploded and killed thirteen persons.
IUBMB Life is the flagship journal of the International Union of Biochemistry and Molecular Biology and is devoted to the rapid publication of the most novel and significant original research articles, reviews, and hypotheses in the broadly defined fields of biochemistry, molecular biology, cell biology, and molecular medicine. The journal publishes interdisciplinary, basic to translational research and covers all fields in the life science at every level of organization: Research communications are original research articles that present new findings of unusually high importance, which provide major new functional insights in biology. Critical Reviews are short, concise, and sharply focused reviews of current hot topics in the biological sciences. Critical Reviews and Hypotheses Papers make new specialized areas highly accessible to all scientists and develop novel insights and approaches for future research.
The most novel part of the conception of the exchange design was the use of pulse amplitude modulation and time division multiplex techniques for the transmission of up to one hundred conversations over a common channel, which was well ahead of its time. This technique would eventually be used in System X and other digital exchanges as technology caught up. Another interesting feature of the installation was the use of time-sharing in the setting-up of the calls and in their control, which was something that all subsequent digital exchange design would follow. At the time in Strowger exchanges ranks of selectors were interconnected by means of a complex trunking system dictated by the method of setting up the calls and by the need to economise in the total number of switching points.
Most novel drug candidates (NCEs) fail during drug development, either because they have unacceptable toxicity or because they simply do not prove efficacy on the targeted disease, as shown in Phase II–III clinical trials. Critical reviews of drug development programs indicate that Phase II–III clinical trials fail due mainly to unknown toxic side effects (50% failure of Phase II cardiology trials), and because of inadequate financing, trial design weaknesses, or poor trial execution. A study covering clinical research in the 1980–90s found that only 21.5% of drug candidates that started Phase I trials were eventually approved for marketing. During 2006–15, the success rate of obtaining approval from Phase I to successful Phase III trials was under 10% on average, and 16% specifically for vaccines.
Fluckiger called the book "easily the most provocative work on sexuality to have appeared in a long time" and credited Tripp with offering a powerful challenge to established views about homosexuality and showing command of a range of data from many fields. He maintained that Tripp offered the most novel account of the way in which behavioral expression communicates internal states since the naturalist Charles Darwin's The Expression of the Emotions in Man and Animals (1872), but considered his most original contribution to be his explanation of how erotic feeling depends on "resistance". The Atlantic Monthly described the book as "well-written", "authoritative", and "indispensable" for readers with a serious interest in homosexuality. It stated that Tripp contradicted most generally held beliefs about the origins of homosexuality with "an impressive mass of evidence".
It was then examined by an appropriate Sardinian committee and the Reale Udienza of Sardinia. The result was a confection of Sardinian and mainland sources, creating a law which was both traditional and novel.. G. Manno, Biografia di S. A. R. il duca del Genevese poscia re C. F., in Note sarde e ricordi, Torino 1868, p. 288 The most novel changes relate to penal law: the abolition of the giudatico (impunity for criminals who had arrested other criminals) and the esemplarità (cruel extensions of the death penalty, like quartering the corpse and scattering the ashes); restrictions on the imposition of the death penalty; affirmation of the principle that the punishment should fit the crime; and the distinction between attempted crimes and crimes actually committed.C. Sole,La Sardegna di Carlo Felice e il problema della terra, Cagliari 1967 p.
Attack roles were generally assigned to dedicated ground-attack aircraft such as the Sukhoi Su-25 and the A-10 Thunderbolt II. A typical US Air Force fighter wing of the period might contain a mix of one air superiority squadron (F-15C), one strike fighter squadron (F-15E), and two multirole fighter squadrons (F-16C). Perhaps the most novel technology introduced for combat aircraft was stealth, which involves the use of special "low-observable" (L-O) materials and design techniques to reduce the susceptibility of an aircraft to detection by the enemy's sensor systems, particularly radars. The first stealth aircraft introduced were the Lockheed F-117 Nighthawk attack aircraft (introduced in 1983) and the Northrop Grumman B-2 Spirit bomber (first flew in 1989). Although no stealthy fighters per se appeared among the fourth generation, some radar-absorbent coatings and other L-O treatments developed for these programs are reported to have been subsequently applied to fourth-generation fighters.
Sōten Kōro's story is based loosely on the events taking place in Three Kingdoms period of China during the life of the last Chancellor of the Eastern Han Dynasty, Cao Cao (155 – March 15, 220), who also serves as the main character. The Three Kingdoms period has been a popular theme in Japanese manga for decades, but Sōten Kōro differs greatly from most of the others on several points. One significant difference is its highly positive portrayal of its main character, Cao Cao, who is traditionally the antagonist in not only Japanese manga, but also most novel versions of the Three Kingdoms period, including the original 14th-century version, Romance of the Three Kingdoms by Luo Guanzhong. Another significant difference from others is that the storyline primarily uses the original historical account of the era, Records of Three Kingdoms by Chen Shou, as a reference rather than the aforementioned Romance of the Three Kingdoms novel.
Reenactment of an early imperial legionary shield array According to Polybius, the scutum gave Roman soldiers an edge over their Carthaginian enemies during the Punic Wars: "Their arms also give the men both protection and confidence, which they owed to the size of the shield." The Roman writer Suetonius recorded anecdotes of the heroic centurion Cassius Scaeva and legionary Gaius Acilius who fought under Caesar in the Battle of Dyrrachium and the battle of Massilia, respectively: The Roman writer Cassius Dio in his Roman History described Roman against Roman in the Battle of Philippi: "For a long time there was pushing of shield against shield and thrusting with the sword, as they were at first cautiously looking for a chance to wound others without being wounded themselves." The shape of the scutum allowed packed formations of legionaries to overlap their shields to provide an effective barrier against projectiles. The most novel (and specialised, for it afforded negligible protection against other attacks) use was the testudo (Latin for "tortoise"), which added legionaries holding shields from above to protect against descending projectiles (such as arrows, spears, or objects thrown by defenders on walls).