However, glioblastoma is considered a grade IV tumor, the most malignant of gliomas.
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But in its most malignant form, hostile architecture can deter homeless folks from resting.
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Senator John McCain has one of the most malignant types of brain tumor, his office disclosed on Wednesday.
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Meanwhile, some of the internet's most malignant rhetoric has been spilling out into the real world with terrifying results.
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Mr. McCain, 20153, has a glioblastoma, one of the most common but also one of the most malignant brain tumors.
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And in Far Cry 5, a game that directly evokes some of the most malignant elements of American culture and politics, it feels particularly disingenuous.
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It had been a hub for some of the most malignant trolls on the internet — including people who had sent me violent anti-Semitic threats in the past.
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" In his resignation letter, Mr. Stern singled out Ms. Mercer and her billionaire father, calling her "an accomplice in one of the most malignant political movements in the country.
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The reckoning around sex and power that has gripped the country during the past year has virtually transformed the culture, and the most malignant strains of male prerogative have been exposed and universally condemned.
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According to Gold, a parallel development occurs in the case of human beings: A loss of a job or other events that lower a person's rank, status, or capacity to make an adequate living are the most malignant stressors that people experience.
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It spreads from the benignant disease uncomplicated partial mole to the most malignant choriocarcinoma in stage IV of disease with brain metastases.
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The P2RX7 receptor is overexpressed in most malignant tumors. The expression of the adenosine A2A receptor on endothelial cells is upregulated in the early stages of human lung cancer.
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The class IA PI3K p110α is mutated in many cancers. Many of these mutations cause the kinase to be more active. It is the single most mutated kinase in glioblastoma, the most malignant primary brain tumor. The PtdIns(3,4,5)P3 phosphatase PTEN that antagonises PI3K signaling is absent from many tumours.
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They are known to grow in the liver, but this finding is usually a manifestation of metastatic disease from a primary carcinoid occurring elsewhere in the body. They have a very slow growth rate compared to most malignant tumors. The median age at diagnosis for all patients with neuroendocrine tumors is 63 years.
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Brain tumours can be either benign or cancerous. Most malignant tumours arise from another part of the body, most commonly from the lung, breast and skin. Cancers of brain tissue can also occur, and originate from any tissue in and around the brain. Meningioma, cancer of the meninges around the brain, is more common than cancers of brain tissue.
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Malignant peripheral nerve sheath tumors are a rare type of cancer that arise from the soft tissue that surrounds nerves. They are a type of sarcoma. Most malignant peripheral nerve sheath tumors arise from the nerve plexuses that distribute nerves into the limbs--the brachial and lumbar plexuses--or from nerves as they arise from the trunk.
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They are the most malignant type of canine mammary tumor. Malignant tumors are also subdivided histopathologically into those showing blood vessel wall invasion and those that do not. Without blood vessel wall invasion there is a better prognosis. Dogs with noninvasive adenocarcinomas have an average survival time of two years, while dogs with invasive adenocarcinomas have an average survival time of one year.
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Individuals with the benign form will have the typical papules persisting anywhere from a few years to throughout their whole lives. In the benign form, no inner organs are affected. If an individual develops the malignant form, it means that not only are the papules present, but inner organs are involved. Most malignant cases involve problems of the gastrointestinal tract leading to small intestine lesions, abdominal pain, diarrhea, and bowel perforation.
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In most cases, thyroid cancer presents as a painless mass in the neck. It is very unusual for thyroid cancers to present with other symptoms, although in some cases cancer may cause hyperthyroidism. Most malignant thyroid cancers are papillary, followed by follicular, medullary, and thyroid lymphoma. Because of the prominence of the thyroid gland, cancer is often detected earlier in the course of disease as the cause of a nodule, which may undergo fine needle aspiration.
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Patients undergoing chemotherapy are administered drugs designed to kill tumor cells. Although chemotherapy may improve overall survival in patients with the most malignant primary brain tumors, it does so in only about 20 percent of patients. Chemotherapy is often used in young children instead of radiation, as radiation may have negative effects on the developing brain. The decision to prescribe this treatment is based on a patient's overall health, type of tumor, and extent of the cancer.
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White wrote in 1864 that tobacco was "a slow, insidious, but most malignant poison." Later text spoke of a member of the church called Doctor Osborn who had not quit, saying that despite his use of tobacco, the judgment lodged against him was more offensive. She was also critical of the consumption of alcohol, saying: "Moderate drinking is the school in which men are educated for the drunkard’s career." Early in 1866, responding to the instruction given to White on Christmas Day in 1865Testimonies for the Church, vol. 1, p.
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Enhanced telomerase activity can be an indicator of abnormal cells. Most normal tissues have inactivated or repressed telomerase activity, but it becomes activated in germ cells and most malignant tumors. Treatment of SPC-A1 cells with gambogic acid resulted in a significant decline in telomerase activity when treated for 48 or 72 hours (detecting 80.7% and 84.9% reduction in activity, respectively). When treated with gambogic acid for only 24 hours, the decrease was only 25.9% which led researchers to believe there are at least two mechanisms responsible for slowing cell growth.
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Ovarian cancer is the most malignant tumour of the female reproductive organs. After endometrial cancer, it is the second most common genital tumour in women with c. 9,000 women newly affected each year and, because of its aggressiveness, it has the highest mortality rate. This is due in part to the fact that there is no screening examination for early detection, and that the disease is therefore usually only discovered at an advanced stage, and in part to the tumour's tendency, although responding well to initial treatment, to recur again later.
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A unit of Army gunners was brought aboard to oversee the use of the mortars. In May 1758 she bombarded the French ports of St Malo and Cherbourg returning to Portsmouth in June. Disease had broken out on board, and a substantial part of the crew were offloaded to the Haslar Hospital, suffering from what surgeon James Lind described as "fevers of the most malignant kind."Lind 1965, p. 111 Replacements having been found, Infernal returned to sea and was present at the Battle of Saint Cast in September.
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A man of doubtful reputation, Alexander's confidant and favourite, he paid the pope a large sum for his elevation. Castellesi served as the de facto if not appointed cardinal protector of England. Castellesi bought a vigna in Borgo near the Vatican, where he built a sumptuous palace designed by Donato Bramante: it is now known as Palazzo Torlonia. In the summer of 1503 he entertained the Pope and Cesare Borgia here at a banquet that went on till nightfall despite the unhealthy season of the year, when ague in its most malignant form was rife.
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A link between vitamin A deficiency and emphysema in smokers was described in 2005 to be due to BaP, which induces vitamin A deficiency in rats. A 1996 study provided molecular evidence linking components in tobacco smoke to lung cancer. BaP was shown to cause genetic damage in lung cells that was identical to the damage observed in the DNA of most malignant lung tumours.Denissenko MF, Pao A, Tang M, Pfeifer GP. Preferential formation of benzo[a]pyrene adducts at lung cancer mutational hotspots in P53. Science. 1996 October 18;274(5286):430-2.
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The film, his first feature to reach theaters, was critically well received, with Desson Howe of The Washington Post reporting that Eckhart is the "movie's most malignant presence" and that he "is in chilling command as a sort of satanic prince in shirtsleeves". In the Company of Men was a critical success, winning Best First Film at the 63rd annual New York Film Critics Circle Award. His performance won him the Independent Spirit Award in the category of Best Debut Performance. The film was ranked as one of "The 25 Most Dangerous Movies" by Premiere magazine.
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KIF2B) as well as cellular activation, proliferation, and apoptosis (e.g. CIDEC, TP52, ATM, KRAS, NRAS, Wnt, and NF- κB). In the most malignant form of plasma cell dyscrasias, primary plasma cell leukemia, the plasma cell population contains >1900 distinct DNA alterations in >600 genes. In general, the plasma cell dyscrasias are defined by 1) the presence of these genetically unstable clonal plasma cells, lymphoplasmacytoid cells, or B cells infiltrating the bone marrow or forming distinct masses in bone, and/or other tissues as defined by biopsy of involved tissues and 2) the presence of these cells' myeloma proteins (i.e.
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Rutledge assaulted Ellery in January 1803, "publicly caning him and pulling him by the nose and ears". Although Rutledge vehemently maintained his innocence in the affair, he decided not to seek reelection in 1803 given the negative publicity. In another curious incident recorded by Channing, "a sudden and most malignant disease appeared in the house of Mr. Nicholas Geffroy... supposed to have originated from some foul substances thrown upon the ground occupied by Mr. Geffroy." Several of Geffroy's mechanics died within a few hours of being attacked, but the illness did not spread beyond a few houses on either side of Geffroy.
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Because the tumor grade is based upon the most malignant portion of the tumor, biopsy or subtotal tumor resection can result in undergrading of the lesion. Imaging of tumor blood flow using perfusion MRI and measuring tumor metabolite concentration with MR spectroscopy may add diagnostic value to standard MRI in select cases by showing increased relative cerebral blood volume and increased choline peak, respectively, but pathology remains the gold standard for diagnosis and molecular characterization. Distinguishing primary glioblastoma from secondary glioblastoma is important. These tumors occur spontaneously (de novo) or have progressed from a lower- grade glioma, respectively.
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Gwin accused Wilson of demagoguery, and Wilson responded by saying he'd rather be thought a demagogue than a thief. Gwin then challenged Wilson to a duel; Wilson declined in the same terms he used to decline a duel with Preston Brooks. In fact neither Gwin nor Wilson wanted to follow through, and commentary about the dispute broke down along partisan lines. One pro-Gwin editorial called the insinuation that Gwin was corrupt "a most malignant falsehood", while a pro-Wilson editorial called his reluctance to take part in a duel evidence that he was "honest" and "conscientious", and had "more respect for the laws of this country than his adversary".
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Because most malignant cells rely on the activity of the protein telomerase for their immortality, it has been proposed that a drug that inactivates telomerase might be effective against a broad spectrum of malignancies. At the same time, most healthy tissues in the body express little if any telomerase, and would function normally in its absence. Currently, inositol hexaphosphate, which is available over-the-counter, is undergoing testing in cancer research due to its telomerase-inhibiting abilities. A number of research groups have experimented with the use of telomerase inhibitors in animal models, and as of 2005 and 2006 phase I and II human clinical trials are underway.
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As they search for answers, the townspeople conclude that they are under siege by extraterrestrial invaders who have come as an advance party to reverse-terraform the Earth so that its altered atmosphere will support their alien physiological needs. In doing so, however, they will poison the planet for its human residents, who must die so that the invaders may live. At all times, while they encounter the most horrible and twisted creatures during their journey, Molly senses that the invaders are of the most malignant kind, and that they want nothing but destruction. After going through different horrors, Molly and Neil are able to save 13 children total, with the help of Virgil and other animals.
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After the initial discovery of the neutron in 1932 by Sir James Chadwick, H. J. Taylor in 1935 showed that boron-10 nuclei had a propensity to capture thermal neutrons. This results in nuclear fission of the boron-11 nuclei into stripped down helium-4 nuclei (alpha particles) and lithium-7 ions. In 1936, G.L. Locher, a scientist at the Franklin Institute in Philadelphia, Pennsylvania, recognized the therapeutic potential of this discovery and suggested that neutron capture could be used to treat cancer. W. H. Sweet, from Massachusetts General Hospital, first suggested the technique for treating malignant brain tumors and a trial of BNCT against the most malignant of all brain tumors, glioblastoma multiforme, using borax as the boron delivery agent in 1951.
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Species 8472 also has an enormous fleet of bioships which are able to go toe to toe with, arguably the Federation's most malignant enemy, The Borg. In the fictional universe of Warhammer 40,000, an extragalactic race known as the tyranids (who swarm entire planets and consume all available biomass to reproduce and further spread to other planets) travel through the galaxy using giant organic bioships known as hive ships that transport the various types of the race inside. These ships travel in large numbers known as hive fleets and are often described as "tendrils" weaving into the galaxy from other galaxies they had previously devoured. Numerous hive fleets have been recorded in the 40K universe and have even been named, with the first recorded fleet designated as Hive Fleet Behemoth.
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It wur nesecerry to be more particular in Virginia than in the other States, because the white people was heavy in the majority, and so we shet down on 'em with the artikkle No. three excluding the most malignant rebbels from the ballot, wharby we killed about phifleen thousand uv the best kind uv votes. We cum at 'em then with fixin' uv the Legislature, and give the niggers a clean majority of 21 thar. And then we phixt the counties so as to git the moast of them, and we A lowed about two hundred officers to a county, so as to have enuff for All. But the worst thing they minded was when we give 'em the Test Oath--that was like a Senter shot, and I noad the dog was certinly Hit by the way he howled when we phixt it.
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