It has become one of the most intractable problems in medicine.
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So was born the subcontinent's most intractable and dangerous political problem.
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So was born the subcontinent's most intractable and dangerous political problem.
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Ethanol has been one of the Trump administration's most intractable problems.
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Immigration has long been one of the most intractable issues in Washington.
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The disposal of nuclear fuel is among the most intractable of infrastructure projects.
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Now Trump faces the world's most intractable conflicts -- and they demand a response.
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And Iran regards Israel, which possesses nuclear weapons, as its most intractable enemy.
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But action is cumulative, and even the biggest, most intractable problems are personal.
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During the past decade Mali has become one of Africa's most intractable security problems.
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The education system is possibly India's most intractable problem, preventing it becoming a consumer powerhouse.
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But he was realistic about his role in one of the most intractable American issues.
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So the virtual companies are being forced to grapple with the most intractable physical issues.
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The homelessness crisis has been the most intractable problem of Mayor Bill de Blasio's tenure.
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Then, Obama warned Trump that North Korea could prove to be his most intractable problem.
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That meeting raised hopes for an end to one of Africa's most intractable military stand-offs.
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But the most intractable difficulty is the pumping of groundwater from ever deeper below the surface.
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Both sides were driven by history and politics in one of the world's most intractable conflicts.
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But in a war with many dilemmas, this may be among the most intractable, analysts say.
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The most intractable issue is home loans, many owed by homeowners who refuse to engage with lenders.
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We are a society in search of an instant fix to some of America's most intractable problems.
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Now, that ingenuity is focused on one of the country's most intractable modern problems: Delhi's toxic air.
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Every few months another app promises to bring tech's disruptive power to bear on our most intractable problems.
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It could take as long again for Swiss courts to resolve the most intractable corporate struggle in Europe.
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The bottom line: The G20 Summit will highlight many of the most intractable problems the U.S. faces abroad.
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Articles, interviews, traction with money and endorsements got the Patrick campaign only so far with the most intractable.
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You are on the brink of solving one of the most intractable problems in American politics— immigration reform.
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Gavin Newsom came out swinging at some of progressives' most intractable bugaboos, including paid parental leave and housing.
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" Instead, the former president suggested the two sides "work together toward solving some of the most intractable global problems.
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It's the most intractable world we can inhabit, and it's the one that will lead to the ugliest outcome.
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Of course, favorable polling doesn't suddenly mean forging agreement on some of America's most intractable problems will be easy.
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By the weekend, she was facing one of Chicago's most intractable problems, when 31 people were shot, three fatally.
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LONDON (Thomson Reuters Foundation) - Could ethical business be the key to ending one of Southeast Asia's most intractable separatist conflicts?
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But a new type of therapy using augmented reality is surprisingly effective at reducing even the most intractable phantom pain.
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Clinton and Mr. Obama, going back to the 2008 campaign, over how to approach one of America's most intractable foes.
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A meeting in Berlin on Sunday will seek an exit to one of the Middle East's most intractable proxy wars.
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Worse still, by bringing the DUP into a governing coalition, May brought out Brexit's most intractable problem: the Irish border crisis.
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The next, he's presiding over covert diplomacy aimed at ending the most intractable foreign policy standoff of the last 70 years.
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Many of our most intractable economic ills can be traced to some degree to this ineluctable fact: America is getting old.
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It would help Mr. Trump argue that he is making progress, albeit slowly, on one of the world's most intractable crises.
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Myanmar's civil war is one of the most intractable conflicts in the world today, up there with the Israeli-Palestinian conflict.
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Much depends on the question of the Irish border — and the proposed "backstop" — which has become the most intractable issue in negotiations.
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Creating a new division of applied scientists to crack some of transportation's most intractable problems seems to be an extension of that.
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Less well-known is the fact that it faces one of France's most intractable problems of Islamic radicalisation outside the Paris region.
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The most effective policymakers weave together the best ideas from a range of perspectives in order to address society's most intractable problems.
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In his tweet on Sunday, Mr. Trump spotlighted Congress's failure to address one of the most intractable issues in Washington: immigration policy.
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"They now again find that the most intractable question is how to reconcile the balances of the Good Friday Agreement with Brexit."
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It's the "ultimate deal," as Trump has called it in his approach to one of the most intractable conflicts in the world.
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His approach -- that he alone with his supposedly masterly negotiating skills can unpick the world's most intractable diplomatic dispute -- now looks exposed.
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More and more Democrats "say they want executive actions or executive orders to solve some of the nation's most intractable problems," Kucinich said.
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Or maybe it's something simpler: a result, perhaps inevitable, of living next door to the most intractable violent conflict of the 21st century.
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The ex-generals and former intelligence chiefs believe that even the most intractable sticking points, such as the fate of Jerusalem, are resolvable.
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But it remains unclear what approach Trump, via Kushner and Greenblatt, plans to take on resolving one of the world's most intractable conflicts.
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Many are also trying to steer its economic benefits to the forlorn towns and neighborhoods that have posed the most intractable economic puzzles.
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And the economic revival plan will be implemented only if a political solution to one of the world's most intractable conflicts is reached.
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If these projects were inspired by dreams of equality, India's large dams have instead entrenched some of the most intractable forms of inequality.
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Swiss drugmaker Novartis wants to become a data science company and use artificial intelligence to solve some of the industry's most intractable problems.
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The conflict has turned into one of the Middle East's most intractable proxy wars, with potentially cascading consequences for stability in Europe's backyard.
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But the most intractable is insistence on the election of the chief executive through universal suffrage — in other words, real Hong Kong democracy.
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Public health experts say there is concern that these attacks are exacerbating what is already one of the world's most intractable public health threats.
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Crafting a viable brain-computer interface is a challenge that weaves together some of tech's trickiest software problems with its most intractable hardware ones.
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But fortunately, the results signal that the American electorate is becoming more supportive of science-backed solutions to confront the nation's most intractable problems.
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It may also herald the eclipse of a kind of discreet diplomacy that for years helped defuse some of the region's most intractable conflicts.
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We can and must embrace the unprecedented opportunities we have to solve the most intractable and ongoing conflicts that continue to plague our world.
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One of the most intractable problems facing negotiators is the spread of Jewish settlements across occupied territory that the Palestinians want for a future state.
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At the same time, his verbal commitment to tackling arguably the world's most intractable conflict has not been matched by bold ideas or new initiatives.
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Third, and knottiest of all, some governments are warming to the idea of weaponising the budget to resolve some of the EU's most intractable disputes.
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Though Congress has come close to passing some type of immigration reform, it has repeatedly failed to resolve one of the country's most intractable debates.
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Maybe it is too much to ask the most powerful world citizens to solve the globe's most intractable problems while frolicking in a winter playground.
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This fantastic piece from Nick Thompson and Fred Vogelstein takes us inside the company's struggle to fix what may be its most intractable problem yet.
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They also underscore the complications of the search for a settlement in Cambodia and illustrate why that remains one of the world's most intractable problems.
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But all of these died with the collapse of the leaders' talks with respect to the fourth and most intractable issue -- the denuclearization of North Korea.
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As their negotiations have dragged on, the status of the Irish language has emerged as one of the most intractable and visibly contested issues at stake.
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If Modi can pull this off, it will buttress his credentials as a reformer brave enough to wade into some of the country's most intractable problems.
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Following the Partition of India in 5003, Pakistan and India fought over the possession of Kashmir, initiating what remains one of the world's most intractable conflicts.
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The West Bank, on the other hand, is densely populated and its future has been the most intractable issue of the Israeli-Palestinian conflict since 1967.
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To solve its most intractable problems, he said, it would have to figure out how to apply artificial intelligence, data science, and other cutting-edge techniques.
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Now, countless entrepreneurs, companies and governments are looking to use similar databases — often independent of Bitcoin — to solve some of the most intractable issues facing society.
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The widely varying quality of the city's neighborhood elementary schools, which have become increasingly segregated since the 1970s, is the public school system's most intractable problem.
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The widely varying quality of the city's neighborhood elementary schools, which have become increasingly segregated since the 1970s, is the public school system's most intractable problem.
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It could treat cancer; it may help us combat some of the most intractable genetic diseases—and it's brought us one step closer to genetically engineered babies.
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A tiny moss that grows in the most arid regions of the world may hold the key to the most intractable problem of the men's bathroom: splashback.
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Trump will seek one anyway, hoping to solve some of the most intractable conflicts with one of America's least trustworthy adversaries in a flashy one-day event.
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The Nordics have been a reliable partner to the U.S. for decades in meeting the most intractable challenges of our time, including threats to peace and security.
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We are learning that one of the most intractable problems with the digital platform model is that advertisers pay to make impressions on viewers but impersonators abound.
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One of the most intractable opponents of the Cuban regime, a Republican congressman in Florida named Lincoln Díaz-Balart, was Fidel Castro's nephew by his first marriage.
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A delegation from Asmara is expected to arrive in the Ethiopian capital this week in a bid to resolve one of Africa's most intractable military stand-offs.
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He's got the big name, most intractable conservatives like Jim Jordan to "yes" and it's a huge help that the most truculent conservative outside groups are now supportive.
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Sanders's views may help the US extricate itself from worrying foreign entanglements — which experts generally applaud — but it may not fix some of the world's most intractable problems.
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The effort, known as Outreach NYC, is the latest attempt from Mayor Bill de Blasio to tackle perhaps the most intractable problem his administration has faced: street homelessness.
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Letter To the Editor: Re "New Priority Means Fewer Beds in City Shelters" (editorial, May 17): Homelessness is among the most intractable and misunderstood challenges our country faces.
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The administration acknowledged that another information-age goal — fighting extremist ideology, including terrorist organizations' ability to continue attracting new recruits — remains one of counterterrorism officials' most intractable problems.
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Described by Trump as the "deal of the century," the Republican president's plan to solve one of the world's most intractable disputes has drawn deep skepticism from Palestinians.
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The legacy of sexual slavery remains one of the most intractable disputes resulting from Japan's colonization of Korea from 1910 to its World War II defeat in 1945.
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Netanyahu was born in Tel Aviv in 1949, a year after Israel's independence and what Palestinians call the Nakba ("catastrophe") forged one of the world's most intractable conflicts.
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Some of these researchers believe machine learning, algorithms and mathematical analysis can give health care providers tools to help solve one of our most intractable public health epidemics: suicide.
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They're already pledging to embark on a take-no-prisoners political crusade — one that also threatens to make the internet's most intractable debate even louder and harder to solve.
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Trump has boasted that with his negotiating skills he can bring Israelis and Palestinians together to resolve one of the world's most intractable conflicts and do "the ultimate deal".
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If we are to solve our most intractable problems, we need political leaders who offer solutions that bring people together and support all of our students, families, and communities.
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It is unfortunately no surprise that the vulnerabilities are vast: high rates of sexual assault endured by campesinas, widespread poverty and dangerous pesticide exposure, to name the most intractable.
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On land, they have light and heavy armor in the form at AT-STs and AT-ATs, giving them heavy platforms to reduce even the most intractable of foes.
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The Trump team concedes that the economic plan — billed "Peace to Prosperity" — will be implemented only if a political solution to one of the world's most intractable conflicts is reached.
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Eritrean President Isaias Afwerki raised hopes of a breakthrough in one of Africa's most intractable conflicts on Wednesday by describing recent peace overtures from arch-enemy Ethiopia as "positive signals".
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NATO is now under pressure to help solve some of the world's most intractable crises and Washington has pushed it to consider its position on China, a growing military power.
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As the threat of Trump has matured, so have Hoffman's political endeavors — beginning with his new efforts to find and fund solutions to some of the country's most intractable political ills.
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Simply handing the microphone to a woman rather than a man when the floor is opened for questions may make a difference, however small, to one of academia's most intractable problems.
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Today, the most intractable problem diesels face is the amount of nasty NOx (mainly nitric oxide and nitrogen dioxide) they emit from their tailpipes (see: "Why diesel cars are under threat").
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The local anger is in stark contrast to the international plaudits Abiy has won for appearing keen to defuse one of the most intractable diplomatic disputes in the Horn of Africa.
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The United States is trying to stop two allies -- Turkey and the Syrian Kurds -- from mauling one another on the margins of the bloodiest, most intractable conflict of the 21st century.
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They are ready to implement policies and pass legislation to address -- to fix -- some of our country's most intractable problems, including inadequate wages, unequal education, gun violence and health care disparities.
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In a joint statement, the two sides said that they had overcome some of the most intractable parts of a peace deal, which they have been negotiating in Havana since 2012.
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A play so serious, so furious and so deeply engaged in the most intractable conflicts of American life that it became both a cause célèbre and a scandal before it opened?
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As Washington and Pyongyang seek to solve the most intractable of conflicts, we should not forget that it is North Korea that has the most to lose if the process fails.
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The relentless toll of graphic videos of people dying can make the issue seem hopeless — police shootings stem from two of the oldest, most intractable American problems, racism and gun violence.
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The disablement of the Arak reactor was among the most intractable issues resolved with the agreement, which will relieve sanctions against Iran in exchange for its verifiable guarantees of peaceful nuclear work.
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It's there — where a physical border with checks and infrastructure has not existed for 2 decades — that complex issues of identity, sectarian violence and trade have coalesced into Brexit's most intractable puzzle.
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In August, Dr. Scott Gottlieb, the agency's commissioner, called the field one of the most promising areas of science and medicine, holding great promise for some of the world's most intractable illnesses.
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For a man who thinks of himself as having an affinity for the downtrodden and disenfranchised populations of this country, President Trump sure can't relate to some of their most intractable problems.
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The most intractable issue during Brexit discussions has for almost two years centered around the future status of the border between the Republic of Ireland and the U.K. nation of Northern Ireland.
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But advocates of the deal, including the Obama administration, praised it, saying that it was an important first step and that it tackled one of the most intractable rifts over reducing carbon emissions.
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London (CNN)The Trump administration's military strike on a Syrian government airbase is barely hours old, but it has plunged the 45th US President headlong into the world's most intractable foreign policy crisis.
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As hard as it is to curb election propaganda, Zuckerberg's most intractable problem may lie elsewhere—in the struggle over which opinions can appear on Facebook, which cannot, and who gets to decide.
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Money is pouring into a new kind of investment strategy — impact investing — aimed at finding and reaching companies like Bosire's, with ideas that could help solve some of the world's most intractable problems.
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It's far more damaging when it influences the makeup of the judiciary, whose legitimacy depends entirely on the public's confidence that it can serve as an impartial arbiter of our most intractable disputes.
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His shock move is consistent with his vow to be a disruptive global force and he is showing characteristic bullish confidence that only he can unpick one of the world's most intractable conflicts.
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Trump will deliver joint remarks with Netanyahu at the White House on Tuesday to outline his plan, which U.S. officials intend to generate momentum toward resolving one of the world's most intractable conflicts.
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But the strike inserted the United States, for a moment at least, into one of the world's most intractable conflicts and demonstrated the potential dangers of Russian and American forces' operating in proximity.
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The solution to one of the deepest and most intractable mysteries facing modern physics might be found in one of Albert Einstein's forgotten theories that the famous physicist abandoned nearly a century ago.
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Visibly buoyed by suggestions from Republican toadies that he already deserved the Nobel peace prize, Mr Trump appeared to believe he was on course to solve one of the world's most intractable security problems.
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It is also a place to learn why it takes extraordinary discipline, courage, and persistence -- often over a lifetime -- to construct new foundations for tackling the most intractable and challenging questions of our time.
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The gunman targeted white officers who were monitoring a group protesting police violence against black civilians, bringing together some of our most intractable problems—rampant gun violence, police brutality—in the most volatile way.
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One of the Bitcoin community's most intractable messaging problems is the incorrect assumption that any one person is in charge—a common misunderstanding for people who don't have much experience with open source protocols.
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The President and his aides have regularly criticized the body for being ineffective at solving the world's most intractable problems and for taking positions on Israel and other matters that oppose the administration's stance.
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The bottom line: If he does triumph, Johnson will take ownership of the most intractable dispute in recent British political history and a divided party that has fallen to once-unthinkable depths in the polls.
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But behind the old town's Belle-Epoque façade, the high-rise neighbourhoods that spread up the ravines beyond the city have become one of the most intractable centres of Islamist radicalism outside the Paris region.
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He sees it as the answer to many of the restaurant industry's most intractable challenges, including the stratospheric cost of real estate and the struggle to pay talented chefs a living wage in expensive cities.
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She said nothing about what that approach would be, nor did she go any further in revealing a coherent picture of United States policy on the conflict, one of the most intractable in the world.
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The current suit is perhaps even more daunting, a case of an ambitious aspiring New Yorker coming head to head with the force and opacity of one of the city's most intractable and immovable institutions.
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The Selfish Ledger positions Google as the solver of the world's most intractable problems, fueled by a distressingly intimate degree of personal information from every user and an ease with guiding the behavior of entire populations.
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The first of them, including the one by Peter Shor that showed how quantum computers could crack global encryption systems, tested the theoretical idea by aiming at the most intractable problems on the biggest notional machines.
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The most intractable are the loss of anonymity and the risk that parts of society will be left out of the financial system, in a world where smartphones and plastic become the only ways to pay.
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That is one reason Matthew Nimetz, a 78-year-old American diplomat, has dedicated more than 20 years to mediating a resolution of what must be one of the world's most arcane, yet most intractable, disputes.
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Mr. Moss also said that when the state took over the Long Island Rail Road, it could have taken another step that might have solved one of the most intractable problems in the city's infrastructure network.
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ADDIS ABABA (Reuters) - Ethiopian Prime Minister Abiy Ahmed greeted a delegation of Eritrean officials at Addis Ababa airport on Tuesday to discuss peace overtures, raising hopes of a breakthrough in one of Africa's most intractable military standoffs.
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She's looking instead for deeper cuts — to understand first whether empathy is inborn or a skill to be learned, and then, either way, to investigate how it can be applied to some of our most intractable problems.
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But perhaps the most intractable problem facing Hyperloop designers is how to deal with not just the jostling, vibration and noise bombarding passengers as the compressed air screamed around the pod, but also the g-forces involved.
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"President Trump obviously doesn't lack for confidence and is not unique in this view that if he could just get leaders in a room he could solve some of the world's most intractable prob-lems," Keiser said.
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ADDIS ABABA (Reuters) - Ethiopia's prime minister will meet the Eritrean president soon as the once-warring nations try to resolve one of Africa's most intractable military stand-offs, Ethiopian state-affiliated media said, citing the foreign minister.
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Matt Harris, a partner at Bain Capital Ventures, said that among the most intractable hurdles facing online lenders were the high cost of acquiring customers and the difficulty of building a relationship that outlasts the first loan.
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How does a group of teenagers – most of them not even old enough to vote – galvanize an offensive that actually forces a change in the law dealing with one of America's most intractable and divisive political issues?
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Comprised of members from anti-bullying research groups, AAA game developers, and some things in between, the board will bring the collective experience of the multi-disciplinary leadership to bear on one of the web's most intractable problems.
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The Jared-Jason jitney — Trump's son-in-law and Jason Greenblatt, his former chief legal officer now charged with resolving the world's most intractable conflict in their spare time — rolls into town but its drivers don't say much.
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It can be hard to know how to deal with the costs without canceling out the benefits; indeed, the openness of the American social networks can appear to be at once their greatest strength and most intractable weakness.
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Mindless immigration policies in 2015 only added oil to fire by feeding and spreading xenophobia as one of the most intractable socio-political issues that is now being dealt with by the EU and Germany's highest judicial authorities.
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"We cannot solve our most intractable problems unless we are honest about what they are, unless we are willing to have difficult conversations and accept what facts make plain," Harris writes in her new memoir, The Truths We Hold.
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Between the lines: Two senior White House officials told Axios they are stunned that Kushner thinks he could be the mediator who solves one of the most intractable problems in American politics for the past 20 years: immigration reform.
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Remember that awkward handshake between foes -- Arafat and Israeli Prime Minister Yitzhak Rabin -- as they embarked on the long and winding road towards peace and accommodation, and a two-state solution to this most intractable of Middle East crises.
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The early results indicate that more homeless individuals were moved to permanent housing since the small pilot began and the providers and city alike believe this could drive systemic change in how the city addresses its most intractable problems.
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Yes, they are capitalists, but rather than bringing them up in the context of Trumps and Kushners, why not appreciate, rather than resent, their commitment of substantial resources and effort to address some of the world's most intractable problems?
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Just four weeks into his tenure as New York City schools chancellor, Richard Carranza has marched into one of the most intractable and divisive problems in New York City's schools: the entrenched segregation of students by race and class.
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Washington (CNN)House Democrats wrested control of the national spotlight Wednesday, leading a sit-in on the floor of the U.S. House of Representatives, chanting over Speaker Paul Ryan, all for gun control -- one of the most intractable issue in Congress.
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Mexico has the second-largest economy in Latin America, it&aposs the third-largest trading partner of the U.S. and a major oil exporter, and it plays a key role in two of America's most intractable problems, immigration and drugs.
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A senior police officer in Peshawar complains that the Afghans have turned an erstwhile "city of flowers" into a place of teeming slums, which harbour the most intractable redoubts of the polio virus, a disease that has nearly been eradicated elsewhere.
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Ever since Britain stunned the world in June 2016 with a referendum setting Brexit in motion, the future of the Irish border has hovered over the proceedings as the single most intractable problem and the element most liable to yield disaster.
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He also delighted in once again presenting himself as a deal maker: tackling one of the world's most intractable security challenges, the threat of North Korea's arsenal of up to 60 nuclear weapons and the missiles on which to deliver them.
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A hastily arranged meeting between two bellicose egomaniacs, premised on a basic misunderstanding, is unlikely to resolve one of the world's most intractable geopolitical conflicts; a flimsy agreement that roughly preserves the status quo seems like a best-case scenario.
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Trump's bravado, arrogance and bad analysis somehow brought him to the conclusion that as the world's greatest negotiator, he or his designated envoy, his son-in-law Jared Kushner, should take on and resolve one of the world's most intractable problems.
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Ignoring the obviously enormous costs associated with both flying taxis and high-speed tunnels for a moment, there's a strain of Silicon Valley thinking that assumes our most intractable problems can be solved by something glossy, mobile, and wrapped in carbon fiber.
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NAIROBI, Kenya (Thomson Reuters Foundation) - When two university students knocked on the door of Lillian Kanari's organic food shop five years ago seeking work, she realized their web design skills could help her business solve one of its most intractable problems: food waste.
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It is not a clear cut case that either Russia or China is ready to relieve Washington of one of its most intractable foreign policy problems, and given differences with the US elsewhere may have an incentive to keep Trump on the hook.
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In fact, some of the most intractable areas in the ongoing negotiations over Nafta are with Canada — like the United States' effort to get rid of a particular type of trade panel that has often ruled in favor of the Canadian lumber industry.
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DUBLIN, Jan 29 (Reuters) - Ryanair plans to implement a new pay structure for its Irish pilots based on the recommendations of an independent mediator, the Irish airline said on Wednesday, in an effort to end one of its most intractable labour disputes.
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DUBLIN, Jan 29 (Reuters) - Ryanair plans to implement a new pay structure for its Irish pilots based on the recommendations of an independent mediator, the Irish airline said on Wednesday, in an effort to end one of its most intractable labor disputes.
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Like many along the 500 km (310 mile) frontier that remains one of the most intractable issues in Britain's negotiations to leave the European Union, the Crockett's farm lies in both the Irish Republic and Northern Ireland, straddling the counties of Donegal and Londonderry.
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LONDON/JERUSALEM (Reuters) - In a 67-word statement composed 100 years ago, Britain endorsed the establishment of a Jewish homeland in the Middle East, triggering a process that would culminate in the creation of Israel - and with it one of the world's most intractable conflicts.
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"This office will bring together the best ideas from government, the private sector, and other thought leaders to ensure that America is ready to solve today's most intractable problems," Trump said in a memorandum creating the office that includes about a dozen White House officials.
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But with Puerto Rico carrying $72 billion in debt after decades of borrowing and overspending, and an independent, federally appointed control board poised to take charge of its finances, municipios — with their mayors, employees and government offices — represent one of the island's most intractable problems.
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"They believe in Detroit, they have been tremendously successful with their first private real estate fund, and they believe that opening access to investment can be a building block for wealth creation and addressing some of the most intractable issues in the society," he said.
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Perhaps more than any modern president — even more than Bill Clinton — he believes in the Great Man theory of history: He believes to his core that his singular charisma and "talent" (a word he uses so often) can solve the world's most intractable problems.
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"But now he is no longer seen, and we are only left to wonder about the boy whose father-in-law placed the hope of unraveling the world's most intractable public policy puzzles from peace in the Middle East to reinventing government" in him.
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Once again she has chosen to use her power for purpose, by putting a spotlight on this devastating disease and illuminating the critical role women can and must play if we want to solve the world's most intractable issues, be they medical, social or legal.
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And just like that, in the course of 45 minutes in the Oval Office, Mr. Trump threw aside caution and dispensed with decades of convention to embark on a daring, high-wire diplomatic gambit aimed at resolving one of the world's most intractable standoffs.
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With only two months left before Britain is due by law to leave the European Union, a narrow majority in the British parliament instructed May on Tuesday to go back to Brussels to revise what is arguably the most intractable part of the deal.
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LONDON, July 30 (Reuters) - Britain's new Prime Minister Boris Johnson will be confronted by the most intractable riddle of Brexit on Wednesday when he visits Northern Ireland on a nationwide tour to sell his plan to pull Britain out of the EU with or without a deal.
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The issue of what to do about the world's most erratic nuclear power looms large over this week's meeting between President Donald Trump and Chinese president Xi Jinping in Florida, and is one of the most intractable foreign policy problems the US has to deal with.
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A day earlier, Gladys Carrión resigned as commissioner of the agency, following two other senior officials tasked with addressing some of the city's most intractable problems: the deputy mayor in charge of health and human services last year, and the Homeless Services Department commissioner several months later.
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Since the public increasingly views air pollution as one of India's most intractable and urgent problems, a tension has grown between the country's need to provide clean air for its citizens and the need to provide power to the nearly 300 million residents who live without electricity.
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The hardest, and likely most intractable, problem is to recognize the validity of claims — claims for recognition of hardship, claims for redistribution of benefits and burdens — when they have been cloaked in language that we rightly regard as indefensible: racist, sexist, xenophobic, anti-Semitic, classist, or ableist.
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And the plans adopt an unrealistic assessment of the starting point for any talks -- in some cases just ignoring impediments that do not fit the White House vision of a solution to these problems and conflicts -- some of the most intractable issues that previous administrations have failed to solve.
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New advances are taking automation to the highest end of human endeavors, offering scientists a shot at some of the most intractable problems that have confounded them — and along the way tipping a global balance to give upstarts like China a more level playing field in the lab.
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Given the rich history of State of the Union addresses, Americans can hope the president will follow in the tradition of his predecessors — act presidential, find common ground in our divided republic, and model civil and respectful discourse to solve some of America's and the world's most intractable problems.
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And after working in many different arenas — from government to think tanks and the charity sector — trying to tackle our most intractable social challenges, it was clear to me that we needed new institutions, creativity and knowledge in order to navigate the growing complexity of our social systems.
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But it foresees allowing goods to flow more or less unimpeded across the border between Ireland, a member of the European Union, and Northern Ireland, which is part of the United Kingdom — a position that would go a long way toward solving one of the most intractable problems facing negotiators.
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Now, they are teaming up to try to influence one of the city's most intractable and divisive debates: how to address the lack of black and Hispanic students at Stuyvesant High School, Bronx High School of Science and the other elite public high schools that use a test to determine admission.
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A gruff "No" is his response when asked if he would consider selling it, though it is unclear that this division, or another that builds lorries, or Ducati, a maker of exotic motorbikes, is a core part of VW. The most intractable problem is low productivity, especially at the mass-market VW brand.
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A few years ago on TechCrunch, Kim-Mai Cutler wrote a deeply-researched analysis of the complexity of these issues, including the permitting process, environmental reviews, community support and opposition, as well as the basic economics of construction that make housing and development one of the most intractable policy problems for municipal leaders.
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While one of the studies was only done in mice, it follows on the heels of FDA approval to use a modified herpes virus to treat melanoma in humans, and heralds a future in which viruses will help harness the body's own immune system to fight some of the most intractable cancers.
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Their presence remains one of the most intractable challenges facing the city: Solutions are complex at best, and finding the proper balance of medical care, casework and law enforcement to ease them off the streets has proved daunting to the de Blasio administration, as it has been to many that came before.
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Our story found that Mr. Wright and his colleagues at the time were accused by regulators — and in one instance, by an internal whistle-blower — of mishandling data on contamination, misrepresenting scientific research on the health risks of dioxin and slowing the Tittabawassee cleanup, one of the nation's most intractable Superfund projects.
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As the richest people in America fixate on how to give money to the poorest, the Cherokee program is a case study of whether a basic income is in fact a practical proposal for alleviating economic inequality or just another oversimplified, undercooked Silicon Valley fix to one of the most intractable problems our society faces.
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There's also a history of duels, fisticuffs and other violence among 19th-century congressmen as the country braced for civil war, and a trove of novels including a World War I story, an immigration narrative and a debut set in Ohio (the book is titled "Ohio") that encompasses some of our culture's most intractable problems.
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The Trump administration released the economic portion of its peace plan during a conference with mainly regional officials in Bahrain last June, but it has yet to unveil the political portion, which will address the most intractable issues -- like the matter of Palestinian statehood, the status of Jerusalem and the fate of Palestinian refugees -- to resolving the conflict.
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The Trump administration released the economic portion of its peace plan during a conference with Arab officials in Bahrain last June, but it has yet to unveil the political portion of its plan, which will address the most intractable issues -- like the matter of statehood, the status of Jerusalem and the fate of Palestinian refugees -- to resolving the conflict.
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The border issue separating Ireland from the U.K.'s Northern Irish province has emerged as one of the most intractable flashpoints of the Brexit debate: after 20 years of open borders and trade following the 1998 Good Friday Agreement, which ended the sectarian conflict between Northern Ireland and the Irish Republic, the U.K. wants to take Northern Ireland out of the EU customs union.
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Read more opinion on CNN (CNN)I want to salute three different groups of heroes that have emerged in these early days of the Covid-19 crisis: the teachers in our public schools; government officials whose leadership skills come to the fore in times like these; and the corporations who share my belief in public-private partnerships to solve the most intractable of problems.
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How to keep EU-member Ireland's 500km (350 mile) border with Northern Ireland open after Brexit is proving the most intractable issue in Britain's tortuous efforts to leave the EU. May's government is now in talks with the opposition Labour Party to build support for her divorce deal that parliament has already rejected three times, forcing a delay of at least six months in the UK's departure date.
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How to keep EU-member Ireland's 500km (350 mile) border with Northern Ireland open after Brexit is proving the most intractable issue in Britain's tortuous efforts to leave the EU. British Prime Minister Theresa May's government is in talks with the opposition Labour Party to build support for a Brexit divorce deal that parliament has already rejected three times, potentially delaying the UK's departure date from the European Union until the end of October.
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Washington (CNN)President Donald Trump announced a broad plan to reform border security and legal immigration during a speech on Thursday afternoon, calling for changes that would favor young, educated immigrants instead of those with family ties to the US. Yet even as Trump cast the measure as a consensus plan that would finally solve one of Washington's most intractable challenges, there were signs the proposal faces an uphill battle for consensus even among the Republican Party's own ranks.
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How to keep EU-member Ireland's currently seamless 500-km (350-mile) border with Northern Ireland open after Brexit and ensure it does not jeopardise two decades of peace in the British province is proving the most intractable issue in Britain's tortuous efforts to leave the EU. Before meeting Varadkar on his arrival at Shannon Airport, Trump said he expected the premier would ask him about Brexit and it would all work out "very well" for Ireland.
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The symbiotic relationship between school and state means that Ms. Christ and her counterparts grapple with the consequences of some of California's most intractable conditions: a housing crisis that forces many students to commute for hours because they cannot afford to live anywhere near the Bay Area; a poverty rate that means some students skip meals and others send financial aid money home; a volatile state budget dependent on the superwealthy and prone to boom-and-bust cycles; and decades of underfunded primary and secondary public schools that strain to educate a diverse student body.
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