This is comparatively benign; its more malignant expressions are much darker.
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However, sharply higher rates accompanied by a flatter yield curve could spell something more malignant.
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Deep-learning algorithms have identified more malignant melanomas and misidentified fewer false positives than human analysts.
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Nowell conjectured that evolutionary forces drive certain cell populations in tumors to become progressively more malignant over time.
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However, we still don't know what the probability is of a single smoking-related DNA mutation turning into cancer, or which mutation types are likely to be more malignant.
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Channeling her sometimes overzealous devotion to the Constitution for dramatic effect, Schreck knows how to build optimism in the American framers before drilling down to its more malignant core.
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No one in any of these situations clicked any links making them vulnerable, and the prankster appears motivated by mischief not anything more malignant, so the severity of these White House pranks should not be overstated.
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But notwithstanding the latest barbs between the world two largest economies, Treasury demand remains strong and likely symptomatic of traders' belief in a larger, more malignant downturn in the global economy and a secular decline in inflation.
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However, the 5 year survival rates in chemotherapy-treated patients with disseminated primary thyroid EMZL or disease that has progressed to a more malignant lymphoma are only 35% and 44%, respectively.
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Chondrosarcoma is a more malignant type of tumor, but most are low grade tumors and often appear in the axial skeletal region. It constitutes 20% of skeletal system tumors in the United States.
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Metastases to regional lymph nodes are extremely rare. Distant hematogenous metastases are even rarer and are most likely in patients who have had multiple local recurrences after inadequate surgical resection. Repeatedly recurring tumors have an increased risk for transformation into a more malignant form (DFSP-FS). The lungs are most frequently affected, but metastases to the brain, bone, and other soft tissues are reported.
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Tumors of the paraganglionic tissues are known as paragangliomas, though this term tends to imply the nonchromaffin type, and can occur at a number of sites throughout the body. Chromaffin paragangliomas are issued from chromaffin cells, and are known as pheochromocytomas. Adrenal pheochromocytomas are usually benign while extraadrenal ones are more malignant. They are most of the time in the adrenals, and only rarely outside of the abdomen.
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Mutations in MYL2 have been associated with familial hypertrophic cardiomyopathy (FHC). Ten FHC mutations have been identified in RLC: E22K, A13T, N47K, P95A, F18L, R58Q, IVS6-1G>C, L103E, IVS5-2A>G, D166V. The first three-E22K, A13T and N47K-have been associated with an unusual mid- ventricular chamber obstruction type of hypertrophy. Three mutations-R58Q, D166V and IVS5-2-are associated with more malignant outcomes, manifesting with sudden cardiac death or at earlier ages.
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For cysts from 1–1.9 cm follow-up is suggested with MRCP or multiphasic CT in 1–2 years. If stable at follow-up, the interval of imaging follow-up is increased to 2–3 years. Cysts from 2–2.9 cm have more malignant potential, and a baseline endoscopic ultrasound is suggested, followed by MRCP or multiphasic CT in 6–12 months. If patients are young, surgery may be considered to avoid the need for prolonged surveillance.
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Most neonates and young children who present with epignathus have exhibited benign tumors, in comparison to older children and adults who have presented with more malignant teratomas. Recent findings have shown some genetic abnormalities associated with epignathi. There have been case reports noting chromosomal irregularities such as a 49,XXXXY karyotype, duplication of 1q and 19p, and ring X chromosome mosaicism. However, this theory is still inconclusive, as there have been other studies that have shown no chromosomal abnormalities.
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Low SMUG1 transcripts can impair DNA repair and thus increase mutation rate, enhance chromosomal instability and promote selection of more malignant clones with aggressive behavior. Loss of SMUG1 was shown to increase cancer predisposition in mice study. In addition low SMUG1 transcripts were shown to be potentially correlated with poor survival and linked to aggressive phenotype in breast cancer. Low SMUG1 expression is also associated with BRCA1, ATM, XRCC1, implying genomic instability in SMUG1 low tumors.
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Springer-Verlag, Berlin, pp. 361–369, 1991. Today, even after more than thirty years, this transplantable tumor model, now established as the MBT-2 tumor and its more malignant derivative MBT-9, are still being used by researchers all over the world to test experimental and targeted therapeutic agents. Dr. Soloway's research was supported by NIH funding throughout his residency in Urology at Case Western Reserve University and as faculty at the University of Tennessee Center for the Health Sciences.
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Congenital mesoblastic nephroma, while rare, is the most common kidney neoplasm diagnosed in the first three months of life and accounts for 3-5% of all childhood renal neoplasms. This neoplasm is generally non-aggressive and amenable to surgical removal. However, a readily identifiable subset of these kidney tumors has a more malignant potential and is capable of causing life- threatening metastases. Congenital mesoblastic nephroma was first named as such in 1967 but was recognized decades before this as fetal renal hamartoma or leiomyomatous renal hamartoma.
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Almost two decades later Appignanesi published Yukio Mishima's Report to the Emperor, a fictional autobiography of the Japanese poet, novelist, playwright, film director, actor and bodybuilder Yukio Mishima (1925–1970), one of the most important Japanese literary and artistic figures of the 20th century as well as an extreme-right activist. Appignanesi's novel is set predominantly in post-World War II reconstruction Japan and in Benares, India. Its narrative builds up to Mishima's horrific ritual suicide by seppuku that accompanied his failed right-wing coup against the Japanese government. The novel explores some of the more malignant recesses of Japanese society and culture.
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February 15, 2013 It's estimated about 150 cases of violence and killings are occurring each year in just the province of Simbu in Papua New Guinea alone. Reports indicate this practice of witch hunting has in some places evolved into "something more malignant, sadistic and voyeuristic." One woman who was attacked by young men from a nearby village "had her genitals burned and fused beyond functional repair by the repeated intrusions of red-hot irons." Few incidents are ever reported, according to the 2012 Law Reform Commission, which concluded that they have increased since the 1980s.
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Just as a population of animals undergoes evolution, an unchecked population of cells also can undergo "evolution". This undesirable process is called somatic evolution, and is how cancer arises and becomes more malignant over time. Most changes in cellular metabolism that allow cells to grow in a disorderly fashion lead to cell death. However, once cancer begins, cancer cells undergo a process of natural selection: the few cells with new genetic changes that enhance their survival or reproduction multiply faster, and soon come to dominate the growing tumor as cells with less favorable genetic change are out-competed.
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All cases arising in pseudocysts had favorable results. Local recurrences of the disease in non-pseudocyst sites did occur but responded to further treatment. Three individuals with disease located in thrombi had serious thromboembolic complications; two the them died from this complication. One individual who had a FA-DLBCL removed from a subdural hematoma developed an Epstein-Barr virus-associated diffuse large B-cell lymphoma (EBV+DLBCL) at a site in the brain near the original hematoma; this case suggests that FA-DLBCL may transform into the far more malignant Epstein-Barr virus-associated lymphoproliferative disease, EBV+ DLBCL.
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Immature, or solid, teratomas are the most common type of ovarian germ cell tumor, making up 40–50% of cases. Teratomas are characterized by the presence of disorganized tissues arising from all three embryonic germ layers: ectoderm, mesoderm, and endoderm; immature teratomas also have undifferentiated stem cells that make them more malignant than mature teratomas (dermoid cysts). The different tissues are visible on gross pathology and often include bone, cartilage, hair, mucus, or sebum, but these tissues are not visible from the outside, which appears to be a solid mass with lobes and cysts. Histologically, they have large amounts of neuroectoderm organized into sheets and tubules along with glia; the amount of neural tissue determines the histologic grade.
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As a member of the RTK family and with responsibilities as diverse as Ephs, it is not surprising to learn that the Ephs have been implicated in several aspects of cancer. While used extensively throughout development, Ephs are rarely detected in adult tissues. Elevated levels of expression and activity have been correlated with the growth of solid tumors, with Eph receptors of both classes A and B being over expressed in a wide range of cancers including melanoma, breast, prostate, pancreatic, gastric, esophageal, and colon cancer, as well as hematopoietic tumors. Increased expression was also correlated with more malignant and metastatic tumors, consistent with the role of Ephs in governing cell movement.
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After Thrawn uncovers and kills rebel Morad Sumar, Pryce and the staff put the factory on lockdown, only for the Jedi rebels, Ezra Bridger and Kanan Jarrus to escape with info about a new TIE fighter project with the help of rebel spy Agent Kallus, who later frames Pryce as the Rebel Spy, leading Lyste to shun her. In "Zero Hour", she learns of Kallus's treason after Thrawn exposes him and later assists Thrawn during the battle of Atollon. When Kallus angers her by saying the Rebels are stronger and more malignant than her, she orders for his imprisonment before he neutralized her two Death Troopers and escapes. In "Jedi Night", she deliberately destroys Lothal's Imperial fuel depot in a failed attempt to prevent the Rebels' escape, killing Kanan in the process.
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