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The Simoceratinae is a subfamily in the Aspidoceratidae, a family of ammonites in the Perisphinctaceae, that lived during most of the Late Jurassic, especially in the Pacific and Tethyan realms. Early genera more closely resemble Perisphictidae and have constricted apertures. Later, more aberrant forms are unconstricted and develop grooved or concave venters.
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The accipitrids have been variously divided into some five to 10 subfamilies. Most share a very similar morphology, but many of these groups contain taxa that are more aberrant. These are placed in their respective position more for lack of better evidence than anything else. It is thus not very surprising that the phylogenetic layout of the accipitrids has always been a matter of dispute.
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Following the historical findings cited above, studies identified the cytokine, interleukin 5 (IL5), as the eosinophil growth-stimulating CFU made by T cells from patients suffering the idiopathic hypereosinophilic syndrome. Subsequent studies likewise identified IL5 as a cytokine being overproduced by certain lymphocytes taken from patients with lymphocyte-variant eosinophilia. These and other studies support the view that lymphocyte-variant hypereosinophilia is a unique disease characterized by hypereosinophilia secondary to the pathological production of eosinophil growth factors, particularly IL5 but possibly also IL4; IL13, and GM-CSF by one or more aberrant clones of T cells. The aberrant T cell clone, as defined by immunophenotyping their expression of certain cell surface molecules, the cluster of differentiation (i.e.
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