844 Sentences With "mammary" | Random Sentence Generator

A mouse's mammary gland that was grown in a lab.

Myoepithelial cells wrapped around milk-producing sacs in a mouse's mammary gland.

I can't go around walking exposing my genitals like they can the mammary glands.

"They'd get stuck in the mammary gland and never reach the baby," Dr. Power said.

And he decided, instead, to punch her right in the mammary gland and fuck up his whole night.

Milk is produced and stored in the breasts by little cavities in the breast tissue called mammary alveoli.

It&aposs produced and stored in the breasts by little cavities in the breast tissue called mammary alveoli.

A sample from a mouse mammary gland, used in research to understand tumor initiation and progression (University of Amsterdam).

As in, they've got ovaries, mammary glands, Fallopian tubes, uteri, rectouterine pouches, cervices, and, last but not least, vaginas.

"The developing brain is also very sensitive to estrogen, as is the mammary gland and the heart," she notes.

"That's important," Trump said, adding that in such a case of mammary mercy, he would stay by Melania's side.

But pumping both breasts increases levels of prolactin, a hormone involved in milk production, and increases mammary gland stimulation.

But her initial studies of mice proved disappointing—their left and right mammary glands didn't seem to differ at all.

It has enormous ears, a bushy tail, mammary glands between its legs and white hairs that bristle when it's agitated.

Myoepithelial cells in the mammary gland contract, moving the milk into the nipple, through the ducts, and into the baby's mouth.

The most common carrier is a rodent of the Mastomys species, 4 to 7 inches long and with 24 mammary glands.

"Because gynecomastia is an overgrowth of the mammary gland, not fat, working out doesn't get rid of it," Dr. Blau writes.

During her admission check-up, shelter workers discovered the cat had a rare form of breast cancer known as bilateral mammary adenocarcinoma.

She's been overbred, has ear infections, skin infections, dry eye in both eyes, and multiple mammary tumors — one as big as an orange.

NTRK genes are rare but occur in many types of cancer, the FDA said, such as mammary analogue secretory carcinoma and infantile fibrosarcoma.

Years later, after her recovery, Ramsdell decided to leave the heart behind and to start looking for asymmetry in the mammary glands of mammals.

In mammals, social isolation has been associated with faster progression of type 2 diabetes, cardiovascular or cerebrovascular disorders, and mammary cancer development, she adds.

Sendler was one of many authors of a mammary gland study that was conducted by the lab and published in the journal Genes and Development.

"The benefits of spaying before your dog's first heat cycle are significant, because it removes the hormones that cause mammary cancer in dogs," says Dr. Zabell.

They took a body cell (a mammary cell extracted from a 6-year-old ewe) and placed it in an ovum with a scooped-out nucleus.

The second dries off the mammary region with a towel to avoid getting salt water in the milk and holds a pump with a suction cup to those slits.

Dr. Delaney's team identified it as a malignant tumor and diagnosed adenocarcinoma, a type of cancer that develops from the body's mucus-secreting glands, like the salivary glands or mammary glands.

When human (non-Laron) mammary cells were mixed with Laron blood serum (low IGF-1) and exposed to hydrogen peroxide to mimic cell damage from oxidation, they were protected from damage.

The sheep, named Dolly Parton because the cell from which they'd cloned her had been taken from a sheep's mammary gland, would be the first cloned mammal to survive into adulthood.

So much so that a group of ad men subliminally decided to use them as inspiration for what we now know as the "double arches," which are a pair of mammary glands.

" In 1997, the first cloned mammal, a sheep derived from a mammary gland cell, was named after her because the scientists "couldn't think of a more impressive pair of glands than Dolly Parton's.

While about 80 percent of breast cancer are diagnosed in the invasive state, about 20 percent are non-invasive, just confined to the ducts of the mammary glands, so-called ductal carcinoma in situ.

When a baby latches onto the nipple, the nerves send impulses to the brain that trigger the release of the prolactin hormone in your pituitary gland, which tells your mammary glands to produce breast milk.

The finding, published Thursday in Science, suggests that despite milk's strong association with mammals—a group named for its lactating mammary organs—nursing behaviors may be widespread in organisms that we wouldn't think of as breastfeeders.

Though the spiders aren't using mammary glands to produce the fluid, and hence are "lactating" in name only, the findings should prompt scientists to reconsider what they know about nursing and how it evolved, the researchers said.

Though T. magnus, an Asian spider that mimics ants, does not have traditional mammary hardware like nipples or udders, it does have a small opening in its abdomen called an "epigastric furrow" from which the spider milk flows.

Still a relatively inefficient technology, SCNT is performed by taking the nucleus from an adult cell (such as a mammary gland, as with Dolly and her clones) and swapping it with the nucleus of a donated egg cell.

Bourgeois's "Arch of Hysteria" (21917), a cloth sculpture of a female figure suspended in midair, levitates more convincingly and, backed up by a full wall of mammary-laden drawings, connects more viscerally with Schiele's work than Polanszky's abstractions.

Lola's Legacy was created in honor of a dog named Lola with an unbreakable spirit, who was saved from overbreeding and survived under the rescue's care for 37 days before succumbing to the massive mammary tumors taking over her body.

If dairy and meat marketers really wanted consumers to know what they are buying, they would be transparent, and they would use descriptions like "bovine mammary secretion" for cows' milk and "carcass" for meat from slaughtered animals, but they don't.

The EPA said Hexythiazox is classified as "likely to be carcinogenic to humans" based on a treatment related to an increase in benign and malignant liver tumors in female mice and the presence of mammary gland tumors in male rats.

Biologists warn against the wanton use of the word milk — sorry, almond "milk" really isn't — and some mammalogists would like to restrict the term to the secretions of a dedicated mammary gland, which only their study subjects happen to possess.

I found myself reminded of these unfulfilled summer dreams — my original mammary failure — as a new mother hunched over a whinging breast pump that for its best efforts could only exert the rare, stingy drop of milk from my sore and feckless tits.

The study doesn't pinpoint which of the chemicals caused the damage, but makes some suggestions: Some aromatic amines, chemicals also found in tobacco smoke and industrial byproducts, disrupt the endocrine system, and some dyes have been found to induce tumors in rats' mammary glands.

Breastmilk is really made up of a few "ingredients," including blood and water, that are synthesized into milk in the mammary gland, Katie Hinde, PhD, associate professor at the School of Human Evolution and Social Change and the Center for Evolution and Medicine at Arizona State University told Refinery29.

The variety of flavors that you eat during pregnancy go into your blood and then into the amniotic fluid, which the baby is constantly drinking, in utero, and the flavors that you eat while nursing cross from the blood vessels that supply the mammary glands into the breast milk.

Then, that person's body gathers "ingredients" to make the milk from their blood, and synthesizes them (sometimes pulling in water) in the mammary gland, says Katie Hinde, PhD, associate professor at the School of Human Evolution and Social Change and the Center for Evolution and Medicine at Arizona State University.

Using a breakthrough technique called somatic cell nuclear transfer, scientists at Roslin took a nucleus -- the part of the cell that contains most of its genetic information -- from cells within the mammary gland of an adult sheep and stuck it inside an unfertilized egg from which the nucleus had been removed.

When a baby is finding it difficult to breast-feed, as McKeever's newborn did, syringe feeding is an alternate method to make sure that the baby gets colostrum, the concentrated milk that is produced in a mother's mammary glands during pregnancy and is expressed in the earliest days of breast-feeding.

If the mockery misfired, it may be because Synthia fits easily into the rhetoric of invented life, the specific kind of whimsy of those who, playing God or not, enjoy playing with words: Dolly, the cloned sheep (named after Dolly Parton, because the sheep was cloned from a mammary cell); cc, the cloned cat; Hercules, the genetically engineered, supermuscular beagle; Eau d'E.

The mammary ridge or mammary crest is a primordium specific for the development of the mammary gland.

The Breast: cross-section scheme of the mammary gland. A mammary alveolus (plural: alveoli, from Latin alveolus, "little cavity") is a small cavity or sac found in the mammary gland. Mammary alveoli are the site of milk production and storage in the mammary gland. Mammary alveoli cluster into groups called mammary lobules, and each breast may contain 15 to 20 of these lobules.

The majority of mammary tumors in mice are caused by mouse mammary tumor virus.

Mouse mammary tumor virus molecular biology and oncogenesis. Viruses 2(9), 2000-2012. doi: 10.3390/v2092000 Whey acidic protein (WAP), is another common promoter used to generate mouse mammary cancer models. For a list of other mammary gland specific promoters and mouse models see.

DMBA induces mammary tumors and allows chemicals that predispose for mammary cancer to increase the number of mammary adenocarcinomas. The results of the study showed that female rats in the control, BPA 25, and BPA 250 groups administered DMBA exhibited a BPA dose-dependent increase in mammary tumors. The groups had 2.84, 3.82, and 5.00 mammary tumors per rat respectively. Treatment with BPA also reduced tumor latency, with the median tumor latency of 65, 53, and 56.5 days for 0, BPA 25, and BPA 250 groups respectively.

Greater expression of QSER1 was also noted in mammary epithelial cells of immortalized cell lines than in mammary epithelial cells from cell lines with finite lifespan.

RANKL knockout mice show an almost identical mammary phenotype to PR knockout mice, including normal mammary ductal development but complete failure of the development of lobuloalveolar structures.

Mammary tumor in a dog A mammary tumor is a neoplasm originating in the mammary gland. It is a common finding in older female dogs and cats that are not spayed, but they are found in other animals as well. The mammary glands in dogs and cats are associated with their nipples and extend from the underside of the chest to the groin on both sides of the midline. There are many differences between mammary tumors in animals and breast cancer in humans, including tumor type, malignancy, and treatment options.

Riegel et al. demonstrate that mouse ME cells isolated from normal mammary glands or from mouse mammary tumor virus (MMTV)-Neu–induced mammary tumors, can be cultured indefinitely as conditionally reprogrammed cells (CRCs). Cell surface progenitor-associated markers are rapidly induced in normal mouse ME-CRCs relative to ME cells. However, the expression of certain mammary progenitor subpopulations, such as CD49f+ ESA+ CD44+, drops significantly in later passages.

These animal findings suggest that, while not essential for full mammary ductal development, progesterone seems to play a potentiating or accelerating role in estrogen-mediated mammary ductal development.

The presence of two pairs mammary glands in the groin area and the absence of mammary glands in the pectoral area is a key feature for this species.

The specific immunodeficient mice that were used were the NOD/SCID mouse (non-obese diabetic/severe conditional immunodeficient). These mutations allow for the integration of new xenograft tissue. The mouse must first have their mammary fat pads humanized by injecting human telemorase-immortalized human mammary stromal fibroblasts(RMF/EG fibroblasts) into the mammary fat pads. Without this injection, the human mammary epithelial cells en-grafted onto the pad are unable to colonize and grow.

Knockout mice of the PR have been found to have severely impaired lobuloalveolar development of the mammary glands as well as delayed but otherwise normal mammary ductal development at puberty.

Using the mammary tumor virus-polyoma middle T-antigen (MMTV-PyMT) mouse model of mammary tumorigenesis, it was shown that reduced Sam68 expression decreases tumor burden and metastasis. Kaplan-Meier curves showed that loss of one sam68 allele (PyMT; Sam68+/-) was associated with a significant delay in the onset of palpable tumors and a significant reduction in tumor multiplicity. These findings suggest that Sam68 is required for PyMT-induced mammary tumorigenesis. The knockdown of Sam68 expression in PyMT-derived mammary cells reduced the number of lung tumor foci in athymic mice, suggesting that Sam68 is also required for mammary tumor metastasis.

This type of tissue can be observed in sweat glands, mammary glands, circumanal glands, and salivary glands. They protect areas such as the ducts of sweat glands, mammary glands, and salivary glands.

The exact causes for the development of canine mammary tumors are not fully understood. However, hormones of the estrous cycle seem to be involved. Female dogs who are not spayed or who are spayed later than the first heat cycle are more likely to develop mammary tumors. Dogs have an overall reported incidence of mammary tumors of 3.4 percent.

Breast: mS100a7a15 is weakly expressed in normal mammary gland tissue.

A functional breast: a mammary gland feeding an infant child.

Mammary stem cells provide the source of cells for growth of the mammary gland during puberty and gestation and play an important role in carcinogenesis of the breast. Mammary stem cells have been isolated from human and mouse tissue as well as from cell lines derived from the mammary gland. Single such cells can give rise to both the luminal and myoepithelial cell types of the gland and have been shown to have the ability to regenerate the entire organ in mice.

Mammary myofibroblastoma (MMFB) is a rare, benign tumor of the breast.

Wnt signaling is an inducer of EMT, particularly in mammary development.

Limb–mammary syndrome is a cutaneous condition characterized by p63 mutations.

Breast cancer metastatic mouse models are experimental approaches in which mice are genetically manipulated to develop a mammary tumor leading to distant focal lesions of mammary epithelium created by metastasis. Mammary cancers in mice can be caused by genetic mutations that have been identified in human cancer. This means models can be generated based upon molecular lesions consistent with the human disease.

It aids in normal mammary gland development. It is necessary for maintenance of the mammary bud. Loss of PTHrP or its receptor causes the mammary bud cell fate to change back into epidermis. In lactation, it may regulate in conjunction with the calcium sensing receptor the mobilization and transfer of calcium to the milk, as well as placental transfer of calcium.

A mammary tumor in a rat. Most mammary tumors in rats are benign fibroadenomas, which are also the most common tumor in the rat. Less than 10 percent are adenocarcinomas. They occur in male and female rats.

A mammary souffle is a maternal cardiac murmur heard over the breasts.

A mammary ridge, or crest, usually stops growing at eight weeks and its length is regressed starting at the caudal end and extending cranially, so that what remains is a round, ectodermic placode where the axilla develops. When shortening of the mammary crest is complete, the structure remains prominent in the areas where the mammary glands eventually form. The mammary lines begin to shorten and ectodermal cells begin to divide and grow into the mesenchymal cell layer. A basement membrane separating the expanding ectodermal crest structure and the underlying mesoderm usually remains.

Terminal end buds (TEBs) are highly proliferative structures at the ends of elongating lactiferous ducts which are involved in development of the mammary glands. TEBs are responsible for the formation of the mammary ductal tree during female puberty.

One sex worker said that mammary intercourse was one alternative used; mammary intercourse performed by a woman with large breasts felt to the client like penetrative vaginal sex.Woods, 1996, in Davis, pages 125-127 Depictions of the practice, at least in advertising, have been described as pornographic or erotic. Mammary intercourse has sometimes been considered a perversion.Clifford Allen, A Textbook of Psychosexual Disorders (1969) p.

Females have enlarged breasts due to functional mammary glands, which develop from puberty onward due to the effects of estrogen. Mammary glands do not contain muscle tissue. The shape of female breasts is affected by age, genetic factors, and body weight.

Article titles included "Attempt to Detect a Mammary Tumor-Agent in Strain C Mice by X-Radiation" (1950), "Transplantation of Hepatomas in Mice" (1955), "Morphology of Mammary Tumors in Mice" (1958),Dunn, Thelma B. "Morphology of Mammary Tumors in Mice" (1958). "Studies of the Mammary-Tumor Agent of Strain RIII Mice" (1961), "Further Studies of the Mammary Tumor Agent of Strain RIII Mice" (1962), "Occurrence of Tumors in Wild House Mice" (1962), "Histology of Some Neoplasms and Non-Neo- plastic Lesions Found in Wild Mice Maintained Under Laboratory Conditions" (1963), "Attempts to Detect Nodule-Inducing Virus in Strain RIII Mice" (1970). In retirement she wrote a book, The Unseen Fight Against Cancer (1975), explaining cancer research for a general readership.

Amazia refers to the absence of one or both mammary glands but the nipples remain present. While athelia refers to the absence of one or both nipples, but the mammary gland remains. Amastia is presumably due to failure of embryologic mammary ridge development, or incomplete involution. People with amastia often suffer from ectodermal defects, which include various syndromes such as cleft palate, isolated pectoral muscle and abnormal formation of upper limb.

Accordingly, it was reported that mammary circRNAs respond slowly to stimulation by growth factors.

In this research article titled "Irradiation of Juvenile, but not Adult, Mammary Gland Increases Stem Cell Self-Renewal and Estrogen Receptor Negative Tumors", two agent-based models were developed and were used in parallel with in vivo and in vitro experiments to evaluate cell inactivation, dedifferentiation via epithelial-mesenchymal transition (EMT), and self-renewal (symmetric division) as mechanisms by which radiation could increase stem cells. The first agent- based model is a multiscale model of mammary gland development starting with a rudimentary mammary ductal tree at the onset of puberty (during active proliferation) all the way to a full mammary gland at adulthood (when there is little proliferation). The model consists of millions of agents, with each agent representing a mammary stem cell, a progenitor cell, or a differentiated cell in the breast. Simulations were first run on the Lawrence Berkeley National Laboratory Lawrencium supercomputer to parameterize and benchmark the model against a variety of in vivo mammary gland measurements.

American Journal of Obstetrician Gynecology, 142, 735-738. In the second half of pregnancy, progesterone and prolactin prepare the mammary glands for lactation.Atwood, C. et al (2000). Progesterone induces side- branching of the ductal epithelium in the mammary glands of peripubertal mice.

During pregnancy until after birth, mammary glands grow steadily to a size required for optimal milk production. At the end of breastfeeding, the number of cells in the mammary gland becomes reduced until approximately the same number is reached as before the start of pregnancy.

Therefore, when amastia patients receive medical ultrasound examination, asymmetry or disproportioned mammary tissue may be found.

And the cow's mammary system has a glandular udder, good size, quite firm and well irrigated.

Though to a far lesser extent than estrogen, which is the major mediator of mammary ductal development (via the ERα), progesterone may be involved in ductal development of the mammary glands to some extent as well. PR knockout mice or mice treated with the PR antagonist mifepristone show delayed although otherwise normal mammary ductal development at puberty. In addition, mice modified to have overexpression of PRA display ductal hyperplasia, and progesterone induces ductal growth in the mouse mammary gland. Progesterone mediates ductal development mainly via induction of the expression of amphiregulin, the same growth factor that estrogen primarily induces the expression of to mediate ductal development.

In mice, Pinc is expressed in the developing embryo and in the mammary glands of adults. Its expression in the mammary gland is induced by pregnancy and drops during lactation. It may have a role in cell survival and in the regulation of cell cycle progression.

Metastasis for any malignant mammary tumor is usually to the regional lymph nodes and lungs. The molecular carcinogenesis of canine mammary tumors are not completely understand. However, the increasing information on molecular pathways involved in the carcinogenesis of this canine tumor has potential to complement and refine the current diagnostic and therapeutic approach to this tumor type. Furthermore, current data show that significant similarities and differences exist between canine and human mammary tumors at the molecular level.

The mammary glands of mammals are specialized to produce milk, the primary source of nutrition for newborns. The monotremes branched early from other mammals and do not have the nipples seen in most mammals, but they do have mammary glands. The young lick the milk from a mammary patch on the mother's belly. Compared to placental mammals, the milk of marsupials changes greatly in both production rate and in nutrient composition, due to the underdeveloped young.

Udder of a cow An udder is an organ formed of two or four mammary glands of dairy animals ruminants such as cattle, goats, and sheep. A mammary gland is equivalent to the breast in primates. The udder is a single mass hanging beneath the animal, consisting of pairs of mammary glands with protruding teats. In cattle, there are normally two pairs, in sheep, goats and deer, there is one pair, and in some animals, there are many pairs.

Thus, the mammary gland and breast milk have critical roles alongside M cells in mucosal immune system.

Adult female and male with clean-shaven pubic regions. A distinguishing characteristic of the class Mammalia is the presence of mammary glands. The mammary glands are modified sweat glands that produce milk, which is used to feed the young for some time after birth. Only mammals produce milk.

These mice developed mammary tumors that were highly metabolic and hyperactive for MTOR. Pre-clinical studies that simultaneously targeted mTOR and metabolism with AZD8055 (inhibitor of mTORC1 and mTORC2) and 2-DG, respectively inhibited mammary tumors from forming. Mitochondria function In control mice that did not have mammary tumors were not affected by AZD8055/2-DG treatments. LKB1 catalytic deficient mutants found in Peutz-Jeghers Syndrome activate the expression of cyclin D1 through recruitment to response elements within the promoter of the oncogene.

The change in intracellular processes and gene regulation causes a decrease in milk production until all milk production from mammary epithelial cells cease. Concentrations of milk-specific components such as lactose and fat will also decrease as milk production decreases. This stage is followed by a steady state period where the mammary glands remain in a non-lactating state. Preceding parturition, parenchymal tissue within the mammary gland will redevelop, allowing the reconstruction of new udder tissue in preparation for lactation.

MMTV codes for the retroviral structural genes and additionally for a superantigen. This stimulates T lymphocytes with a certain type of V beta chain in their T cell receptor, which in turn stimulates B cell proliferation increasing the population of cells that can be infected. During puberty, the virus enters the mammary glands with migrating lymphocytes and infects proliferating mammary gland epithelial cells. As a retrovirus the mouse mammary tumor virus (MMTV) is able to insert its viral genome in the host genome.

Endogenous MMTV reacts to the whole range of hormones that regulate normal mammary development and lactation, response has been demonstrated to steroid hormones (androgens, glucocorticoids and progestins), as well as prolactin. When the mouse reaches puberty the virus begins to express its messenger RNA in the estrogen sensitive tissues. As a result, after puberty all mammary cells will contain the active retrovirus and begin to replicate in the genome and express viral messenger RNA in all new mammary tissue cells.

In some cases, the mammary intercourse can be combined with oral sex by the woman who, through fellatio, can bring the man to orgasm. Mammary intercourse may be carried out face to face or head to tail. Mammary intercourse is mostly suited for women with naturally larger breasts, while it is recommended that woman with smaller breasts be on top.Alex Comfort, The Joy of Sex (1972) p. 69 Smaller female breasts, however, tend to be more sensitive than larger ones.

Females have one genital slit, housing the vagina and the anus, with a mammary slit on either side.

Derlin 1 (DERL1) is up-regulated in metastatic canine mammary tumors as part of the unfolded protein response.

The mammary ridge is primordial for the mammary gland on the breast in humans, and is associated with mammary gland and breast development. In human embryogenesis the mammary ridge usually appears as a narrow, microscopic ectodermal thickening during the first seven weeks of pregnancy and grows caudally as a narrow, linear ridge. In many mammals, these glands first appear as elevated ridges along the milk lines, which then separate into individual buds located in regions lateral to the ventral midline. The location of these buds varies according to species: they are located in the thoracic region in primates, in the inguinal area in ungulates, and along the entire length of the trunk in rodents and pigs.

What counts as a synapomorphy for one clade may well be a primitive character or plesiomorphy at a less inclusive or nested clade. For example, the presence of mammary glands is a synapomorphy for mammals in relation to tetrapods but is a symplesiomorphy for mammals in relation to one another—rodents and primates, for example. So the concept can be understood as well in terms of "a character newer than" (autapomorphy) and "a character older than" (plesiomorphy) the apomorphy: mammary glands are evolutionarily newer than vertebral column, so mammary glands are an autapomorphy if vertebral column is an apomorphy, but if mammary glands are the apomorphy being considered then vertebral column is a plesiomorphy.

Historically, about 50 percent of mammary tumors in dogs were found to be malignant, although taking into account tumor behavior, one study has estimated true malignancy in mammary tumors to be 21 to 22 percent. Adenomas and fibroadenomas make up the benign types. Malignant mammary tumors are divided into sarcomas, carcinosarcomas, inflammatory carcinomas (usually anaplastic carcinomas), and carcinomas (including adenocarcinomas), which are the most common. Inflammatory carcinomas describe tumors that are fast growing and have bruising, edema, and pain, and can also cause disseminated intravascular coagulation.

RANK is constitutively expressed in mammary epithelial tissues. Calcium transferred from mother to fetus and neonate is provided by the degradation of the female bone by increased osteoclastic activity, which is regulated by the RANK/RANKL axis. RANKL also works through RANK to provide proliferative and survival signals to promote the final stages of lactating mammary gland development. Dysfunctional RANK or RANKL causes the arrest of differentiation and expansion of the alveolar bunds into mature lobulo-alveolar mammary structures, disabling the production of milk.

Specialized sweat glands, including the ceruminous glands, mammary glands, ciliary glands of the eyelids, and sweat glands of the nasal vestibulum, are modified apocrine glands. Ceruminous glands are near the ear canals, and produce cerumen (earwax) that mixes with the oil secreted from sebaceous glands. Mammary glands use apocrine secretion to produce milk.

250x250px Mammary glands are arranged in breasts of the primates to produce milk for feeding offspring. They are enlarged and modified sweat glands. In the embryological development, mammary glands firstly appear after six weeks of pregnancy in the form of ectodermal ridges. The ectodermal ridge grows thicker and compresses to form mesoderm.

SCGB1D2 expression is high in mammary tissue, and is sometimes used for identification and detection of disseminated breast cancer cells.

Danazol in the Treatment of Mammary Dysplasia. Drugs(19), 349-355.Greenblatt, R., Mahesh, V., & Dmowski, P., Scholoer, H. (1969).

Based on its mixed effects in different tissues, estetrol has been described as a unique, "natural" selective estrogen receptor modulator (SERM) rather than as a "weak estrogen." Estetrol is weakly estrogenic in breast/mammary gland, but shows very low potency in this tissue and, when administered in combination with estradiol, antagonizes the effects of estradiol. Relative to estradiol, estetrol shows 100-fold lower potency in stimulation of the proliferation of human breast epithelial cells in vitro and of mouse mammary gland cells in vivo. In animal models, estetrol shows antiestrogenic effects in mammary gland tissue comparable to those of the SERM tamoxifen and of ovariectomy, antagonizing the stimulatory effects of estradiol and preventing tumor development in a 7,12-dimethylbenz(a)anthracene (DMBA) mammary tumor model.

In human lactation, glucose is changed into galactose via hexoneogenesis to enable the mammary glands to secrete lactose. However, most lactose in breast milk is synthesized from galactose taken up from the blood, and only 35±6% is made from galactose from de novo synthesis. Glycerol also contributes some to the mammary galactose production.

Mammary tumors are the third most common neoplasia in cats, following lymphoid and skin cancers. The incidence of mammary tumors in cats is reduced by 91 percent in cats spayed prior to six months of age and by 86 percent in cats spayed prior to one year, according to one study. Siamese cats and Japanese breeds seem to have increased risk, and obesity also appears to be a factor in tumor development. Malignant tumors make up 80 to 96 percent of mammary tumors in cats, almost all adenocarcinomas.

Nevertheless, mouse ME-CRCs grown in a three-dimensional extracellular matrix gave rise to mammary acinar structures. ME-CRCs isolated from MMTV-Neu transgenic mouse mammary tumors express high levels of HER2/neu, as well as tumor-initiating cell markers, such as CD44+, CD49f+ and ESA+ (EpCam). These patterns of expression are sustained in later CRC passages. Early and late passage ME-CRCs from MMTV-Neu tumors that were implanted in the mammary fat pads of syngeneic or nude mice developed vascular tumors that metastasized within 6 weeks of transplantation.

Targeted disruption of the related gene in mice led to severe osteopetrosis and a lack of osteoclasts. Deficient mice, with an inactivation of RANKL or its receptor RANK, exhibited defects in early differentiation of T and B lymphocytes, and failed to form lobulo-alveolar mammary structures during pregnancy. It was observed that during pregnancy, RANK-RANKL signaling played a critical role in regulating skeletal calcium release; in which contributed to the hormone response that stimulated proliferation in the mammary cells. Ultimately, impaired lobuloalveolar mammary structures resulted in death of the fetus.

It was concluded that perinatal exposure to low doses of BPA results in altered mammary gland morphogenesis, induction of precancerous lesions, and carcinoma in situ. A study sought to determine whether early exposure to BPA could accelerate mammary carcinogenesis in a dimethylbenzanthracene (DMBA) model of rodent mammary cancer. In the study, scientists exposed neonatal/prebubertal rats to BPA via lactation from nursing dams treated orally with 0, 25, and 250 µg BPA/kg body weight/day. For tumorigenesis studies, female offspring were exposed to 30 mg DMBA/kg body weight at 50 days of age.

SCGB2A1 expression is highly specific of mammary tissue, and has been used for identification and detection of disseminated breast cancer cells.

SCGB2A2 expression is highly specific of mammary tissue, and is increasingly used for identification and detection of disseminated breast cancer cells.

In January 2013 her group proved that vitamin D plays an important role in preventing risk of mammary and breast cancer.

This addresses the issue in terms of modeling the amplification of HER2 in mice development. In the non-fused mouse, the mammary gland would revert to a near virgin, but with this addition the mammary gland maintained the developed function.Fry, EA; Taneka, P; Inoue, K. (2016). Oncogenic and tumor-suppressive mouse models for breast cancer engaging HER2/neu.

TS/A is a mouse mammary adenocarcinoma cell line established in the early 1980s from a spontaneous tumor of a retired breeder BALB/c female mouse.Nanni P, C De Giovanni, P-L Lollini, G Nicoletti, and G Prodi. 1983. "TS/A: a new metastasizing cell line from a BALB/c spontaneous mammary adenocarcinoma". Clinical and Experimental Metastasis.

Breast cancer: mS100a7a15 is upregulated in DMBA induced mammary gland tumors confined to epithelial tumor cells. mS100a7a15 overexpression in mammary epithelial cells enhances proliferation, angiogenesis and metastasis through induction of prometastatic and angiogenic factors like CCL2, Cox-2, MMP2, MMP9 and VEGF. Furthermore mS100a7a15 recruits tumor-associated-macrophages (TAM) through RAGE and Stat3 activation to promote tumorigenesis.

In molecular biology, ZNFX1 antisense RNA 1, also known as ZNFX1-AS1 or ZFAS1, is a long non-coding RNA. It is expressed in the lung and mammary gland in mice. Its expression is down-regulated in mammary tumours, it may function as a tumour suppressor gene. The ZNFX1-AS1 gene hosts three snoRNA genes (SNORD12, SNORD12B and SNORD12C)).

Mastitis occurs when white blood cells (leukocytes) are released into the mammary gland, usually in response to bacteria invading the teat canal or occasionally by chemical, mechanical, or thermal trauma on the udder. Milk-secreting tissue and various ducts throughout the mammary gland are damaged due to toxins released by the bacteria resulting in reduced milk yield and quality.

Impaired Mammary Gland Development in Cyl-12/2 Mice during Pregnancy and Lactation Is Epithelial Cell Autonomous. Developmental Biology, 212, 1–11.

Microdochectomy is the surgical removal (excision) of a lactiferous duct. A mere incision of a mammary duct (without excision) is called microdochotomy.

Metastatic canine mammary carcinoma and their metastases are characterized by decreased HEPACAM2 but unchanged HEPACAM2 expression levels when compared to normal glands.

The mammary ridge then becomes recognizable in the thoracic region in the human embryo. Nipples develop on the milk lines of mammals.

The females have four pairs of mammary glands. The snout is pointed, the ears are rounded and the long slender tail is hairless.

While the origins of the human milk microbiome are not exactly known, several hypotheses for its establishment have been proposed. Bacteria present in human milk may be derived from the surrounding breast skin flora, or the infant's oral cavity microbiota. Retrograde backflow during nursing or suckling may also lead to bacterial establishment in the mammary ducts, supported by the observation that a certain degree of flowback has been shown to occur during nursing using infrared photography. Alternatively, bacteria may be translocated to the mammary duct from the maternal gastrointestinal tract via an entero-mammary pathway, facilitated by dendritic cells.

Experiments have shown that exposure to ionizing irradiation of pubertal mammary glands results in an increase in the ratio of mammary stem cells in the gland. This is important because stem cells are thought to be key targets for cancer initiation by ionizing radiation because they have the greatest long-term proliferative potential and mutagenic events persist in multiple daughter cells. Additionally, epidemiology data show that children exposed to ionizing radiation have a substantially greater breast cancer risk than adults. These experiments thus prompted questions about the underlying mechanism for the increase in mammary stem cells following radiation.

237–249 It has been said that breast implants are not flexible enough to sustain mammary intercourse. The woman does not receive direct sexual stimulation during mammary intercourse, other than the erotic stimulation of bringing her sexual partner to orgasm, without sexual penetration. However, Alex Comfort has said that mammary intercourse can produce orgasm in women with sensitive breasts (what Margot Anand terms local orgasms of the breast), and it was one of the nine substitute exercises for penetrative sexual activities, as detailed in the Paradis Charnels of 1903.Alex Comfort, The Joy of Sex (1972) pp.

Bio-active components in human milk are speculated to colonize in human milk in several ways including secretion by the mammary gland, epithelium cells, and by milk cells. Maternal immune factors are transferred by lymphocytes traveling from the mother's gut to the mammary gland where the secretory cells of the breast produce antibodies. The origin of the human milk microbiota, including those with immune-modulating functions, are not well established. However, several theories including skin-to-skin contact, the entero-mammary pathway, and retrograde back-flow hypothesis have been put forth to explain the microbial composition of human milk.

Using lineage tracing of basal cells and luminary mammary gland cells during embryonic development and post-natal development, the Blanpain lab showed that different mammary tissue lineages stem from multipotent embryonic progenitors. These multipotent progenitors are replaced soon after birth by unipotent stem cells. His group developed new techniques to perform quantitative lineage tracing to unravel the multilineage differentiation potential of stem cells during development and adult homeostasis. Using novel lineage tracing strategies, they demonstrated that ER positive cells in the mammary gland developed and are maintained in adult gland through unipotent progenitors that are restricted to hormone receptor expressing cells.

Appearance and location of the tumor is enough to identify it as a mammary tumor. Biopsy will give type and invasiveness of the tumor. In addition, newer studies showed that certain gene expression patterns are associated with malignant behaviour of canine mammary tumors. Surgical removal is the treatment of choice, but chest x-rays should be taken first to rule out metastasis.

Duct ectasia of the breast, mammary duct ectasia or plasma cell mastitis is a condition in which occurs when a milk duct beneath the nipple widens, the duct walls thicken and the duct fills with fluid. This is the most common cause of greenish discharge. Mammary duct ectasia can mimic breast cancer. It is a disorder of peri- or post-menopausal age.

For example, in normal condition, mammary ridge (milk line) would extend from the bilateral axillary tail to the inguinal region. If this extension does not occur in normal way, the breast would not develop successfully. Amastia may also be caused by the inability of producing parathyroid hormone related protein. The absence of this protein will disrupt the normal development of mammary gland.

There are two known isoforms of SIM2 which play different roles in various tissues. The isoform SIM2 Short (SIM2s) has been shown to be specifically expressed in mammary gland tissue. SIM2s is a splice variant which lacks exon 11 of SIM2. It has been researched that SIM2s acts in mammary gland development and has tumor suppressive characteristics specifically in breast cancer.

Other components found in raw cow's milk are living white blood cells, mammary gland cells, various bacteria, and a large number of active enzymes.

The parasternal line is a vertical line on the front of the thorax. It is midway between the lateral sternal and the mammary line.

The show is a production of "The Tapes Team" at SIRIUS, along with Master Tape Theatre, Mammary Lane, and The History of Howard Stern.

More recently, it was discovered that CSF-1 and its receptor CSF1R are implicated in the mammary gland during normal development and neoplastic growth.

It results in vasodilation, renoprotection, mammary gland development, etc. Sulfated steroids and bile acids are also detected by vomeronasal receptors, specifically the V1 family.

Progesterone prepares the uterus for pregnancy, and the mammary glands for lactation. Progesterone functions with estrogen by promoting menstrual cycle changes in the endometrium.

Moreover, suppression of PGE2 in breast tissue is relevant because, via activation of prostaglandin EP receptors, PGE2 potently induces amphiregulin expression in breast tissue, and activation of the EGFR by amphiregulin increases COX-2 expression in breast tissue, in turn resulting in more PGE2, and thus, a self-perpetuating, synergistic cycle of growth amplification due to COX-2 appears to potentially be present in normal breast tissue. Accordingly, overexpression of COX-2 in mammary gland tissue produces mammary gland hyperplasia as well as precocious mammary gland development in female mice, mirroring the phenotype of VDR knockout mice, and demonstrating a strong stimulatory effect of COX-2, which is downregulated by VDR activation, on the growth of the mammary glands. Also in accordance, COX-2 activity in the breasts has been found to be positively associated with breast volume in women.

There are several hypotheses on the molecular mechanisms involved in the development of canine mammary tumors but a specific genetic mutation has not been identified.

The hallux (big toe) bears a nail rather than a claw, a unique characteristic of this genus. The female has three pairs of mammary glands.

The action of iodine in mammary tissue is related to fetal and neonatal development, but in the other tissues, it is (at least) partially unknown.

Estrogens and progesterone promote mammary epithelial cell proliferation resulting in the formation of the primary and secondary ductal structure. Progesterone induces formation of tertiary side-branches in the mammary glands during puberty and during the luteal phase of the menstrual cycle upon which lobuloalveolar structures form under the influence of prolactin. Prolactin stimulates lactogenesis.Fantl, V., Edwards, P., Steel, J., Vonderhaar, B., & Dickson, C. (1999).

S100A2, also known as CaN19 or S100L was first isolated from bovine lung tissue. However, in human tissue it was discovered several years later, in the mammary epithelial cells. Under normal circumstances it is highly expressed in human lungs, prostate, kidneys, hair follicles and salivary and mammary glands. S100A2 is predominantly found in the nucleus, which is not very common in other S100 proteins.

Bisphenol A (BPA) is an example of an endocrine disruptor which negatively affects reproductive development. BPA is a known as an estrogen mimicker (Xenoestrogen) and a likely androgen mimicker. It is used in the production of various plastic products. BPA exposure in fetal female rats leads to mammary gland morphogenesis, increased formation of ovarian tumors, and increased risk of developing mammary gland neoplasia in adult life.

The prevalence in dogs is about three times that of women. In dogs, mammary tumors are the second most common tumor (after skin tumors) over all and the most common tumor in female dogs with a reported incidence of 3.4%. Multiple studies have documented that spaying female dogs when young greatly decreases their risk of developing mammary neoplasia when aged. Compared with female dogs left intact, those spayed before puberty have 0.5% of the risk, those spayed after one estrous cycle have 8.0% of the risk, and dogs spayed after two estrous cycles have 26.0% of the risk of developing mammary neoplasia later in life.

TBX3 has been implicated in human diseases including the ulnar mammary syndrome, obesity, rheumatoid arthritis and cancer. In humans, heterozygous mutations of TBX3 lead to the autosomal dominant developmental disorder, ulnar mammary syndrome (UMS), which is characterized by a number of clinical features including mammary and apocrine gland hypoplasia, upper limb defects, malformations of areola, dental structures, heart and genitalia. Several UMS causing mutations in the TBX3 gene have been reported which include 5 nonsense, 8 frameshift (due to deletion, duplication and insertion), 3 missense and 2 splice site mutations. Missense mutations within the T-domain, or the loss of RD1 result in aberrant transcripts and truncated proteins of TBX3.

A well known tumor virus of the mouse is the mouse mammary tumor virus, which may be the most common cause of this tumor in mice.

Heart-type fatty acid binding protein (hFABP) also known as mammary-derived growth inhibitor is a protein that in humans is encoded by the FABP3 gene.

Extra nipples or breasts sometimes appear along the mammary lines of humans, appearing as a remnant of mammalian ancestors who possessed more than two nipples or breasts.

Casein kinase activity associated with the endoplasmic reticulum of mammary glands was first characterized in 1974, and its activity was shown to not depend on cyclic AMP.

Sterneck began to study the functions of CCAAT-enhancer-binding proteins (C/EBP) transcription factors, including their roles in normal mammary gland development, through genetically engineered mice.

Human mammary tumor virus (HMTV) is a B-type retrovirus that is closely related to the mouse mammary tumor virus (MMTV). The existence of this virus was suspected for decades but nucleotide sequences identifying a unique virus in human breast cancer tumors were not confirmed until 2001. Viral particles were isolated several years later. Evidence for a role of HTMV/MMTV in human breast cancer has recently been reviewed.

Lactiferous ducts are those ducts that converge and form a branched system connecting the nipple to the lobules of the mammary gland. When lactogenesis occurs, under the influence of hormones, the milk is moved to the nipple by the action of smooth muscle contractions along the ductal system to the tip of the nipple. They are also referred to as galactophores, galactophorous ducts, mammary ducts, mamillary ducts or milk ducts.

In addition, this study showed increased in vivo liver metastasis by the breast cancer with c-jun overexpression. This finding suggests that c-jun plays a critical role in the metastasis of breast cancer. In mammary tumors, endogenous c-jun was found to play a key role in ErbB2-induced migration and invasion of mammary epithelial cells. Jun transcriptionally activates the promoters of SCF (stem cell factor) and CCL5.

Spaying and neutering holds many advantages for cats, including lowering the risk of developing cancer. Neutering male cats makes them less subject to testicular cancer, FeLV, and FIV. Spaying female cats lowers the risk of mammary, ovarian, and uterine cancer, as it prevents them from going into heat. Female cats should be spayed before their first heat, as each cycle of heat creates a greater risk of mammary cancer.

Increased levels of CSF1R1 are found in microglia in Alzheimer's disease and after brain injuries. The increased receptor expression causes microglia to become more active. Both CSF1R, and its ligand colony stimulating factor 1 play an important role in the development of the mammary gland and may be involved in the process of mammary gland carcinogenesis. Mutations in CSF1R are associated with chronic myelomonocytic leukemia and type M4 acute myeloblastic leukemia.

Various mouse mammary carcinoma cell lines, like 4T1Pulaski BA, S Ostrand-Rosenberg. 2001. "Mouse 4T1 breast tumor model". Curr Protoc Immunol. Chapter 20:Unit 20.2. doi: 10.1002/0471142735.

Emaciated female dog with a 9-month-old mammary tumor. The same, closer Radiograph (x-ray) of an affected dog. The metastases cause the dog difficulty in breathing.

The tumors can be large and occur anywhere on the trunk. There is a good prognosis with surgery. Spayed rats have a decreased risk of developing mammary tumors.

During mouse embryonic development, Tbx3 is expressed in the inner cell mass of the blastocyst, in the extraembryonic mesoderm during gastrulation, and in the developing heart, limbs, musculoskeletal structures, mammary glands, nervous system, skin, eye, liver, pancreas, lungs and genitalia. Tbx3 null embryos show defects in, among other structures, the heart, mammary glands and limbs and they die in utero by embryonic day E16.5, most likely due to yolk sac and heart defects. These observations together with numerous other studies have illustrated that Tbx3 plays crucial roles in the development of the heart, mammary glands, limbs and lungs. TBX3 has been implicated in the regulation of Wnt target genes by tissue-specific crosstalk with the protein BCL9 .

Prolactin, a major hormone of the HPP axis. The hypothalamic–pituitary–prolactin axis (HPP axis), also known as the hypothalamic–pituitary–mammary axis or hypothalamic–pituitary–breast axis, is a hypothalamic–pituitary axis which includes the secretion of prolactin (PRL; luteotropin) from the lactotrophs of the pituitary gland into the circulation and the subsequent action of prolactin on tissues such as, particularly, the mammary glands or breasts. It is involved in lobuloalveolar maturation of the mammary glands during pregnancy and the induction and maintenance of lactation following parturition. Hormones that control the secretion of prolactin from the pituitary gland include dopamine ("prolactin-inhibiting factor", or "PIF"), estradiol, progesterone, thyrotropin-releasing hormone (TRH), and vasoactive intestinal peptide (VIP).

At very low levels the FDA has long considered BPA in food to be safe, but this has been challenged over the years as more information is discovered regarding the effects of the chemical. Rats exposed prenatally to environmentally relevant doses of BPA show an increased number of intraductal hyperplasias (precancerious lesions) in mammary glands that appear during adulthood, while high doses induce the development of carcinomas in breast tissue. Animals exposed to BPA during fetal life develop palpable tumors, and all studies show an increased susceptibility to mammary gland neoplasia that manifests during adulthood. Exposure of mouse dams to environmentally relevant levels of BPA during organogenesis results in considerable alterations in the mammary gland.

GPER knockout mice have also been generated, and exhibit obesity, cardiovascular dysfunction, insulin resistance, glucose intolerance, differences in mammary carcinogenesis and metastasis, and differences in central nervous system function.

Integrins also serve as receptors to trigger signal transduction cascades when binding to the ECM. A well-studied example of morphogenesis that involves ECM is mammary gland ductal branching.

Jarid1B has been implicated in the development of prostate, breast, and skin cancer and also has been associated with melanoma maintenance. Knockout mice (Jarid1b−/−) produced are viable in neonatal life. These mice do exhibit the phenotype of premature mortality, decreased fertility in female mice, reduction in body weight and impairment in mammary gland development. It also acted to decrease serum estrogen levels and caused reduced mammary epithelial cell proliferation in the early stages of puberty.

In Canada, each breed is compared to a different breed conformation chart. The traits are split into 4 sections: Rump, Mammary System, Dairy Strength, and Feet and Legs. Each of the traits that falls under these categories is assigned a percentage of the total component. The weight of each of the four major categories by breed all place the highest value on mammary system, with value percentages ranging from 40 to 48 percent.

Most primates have two mammary glands, but the number and positions vary between species within strepsirrhines. Lorises have two pairs, while others, like the ring-tailed lemur, have one pair on the chest (pectoral). The aye-aye also has two mammary glands, but they are located near the groin (inguinal). In females, the clitoris is sometimes enlarged and pendulous, resembling the male penis, which can make sex identification difficult for human observers.

Prolactin has a wide variety of effects. It stimulates the mammary glands to produce milk (lactation): increased serum concentrations of prolactin during pregnancy cause enlargement of the mammary glands and prepare for milk production, which normally starts when levels of progesterone fall by the end of pregnancy and a suckling stimulus is present. Prolactin plays an important role in maternal behavior. In general, dopamine inhibits prolactin but this process has feedback mechanisms.

Mitchell Mammary is a Lebanon international rugby league footballer who plays as a for the Wentworthville Magpies. He was selected to represent Lebanon in the 2017 Rugby League World Cup.

Besides, a more recent work by Pattanayak et al. (2008) shows significant tumor reduction in induced mammary carcinogenesis in Wistar female rats when fed with hydroalcoholic extracts of D. falcata.

The induced SCF and CCL5 expression promotes a self-renewing mammary epithelial population. It suggests that c-jun mediates the expansion of breast cancer stem cells to enhance tumor invasiveness.

However, a role of PSMA5 was also indicated in neuroendocrine pulmonary tumors. The PSMA5 protein has further been associated with the biosynthesis of conjugated linoleic acid (CLA) in mammary tissue.

Mammary tumors in beagle dogs treated by (left) MK-665 (ethynerone with mestranol) and (right) chloroethynylnorgestrel with mestranol for 4 years at a dosage of 1.05 mg/kg/day cyclically.

Then the infant turns towards the mammary glands and after suckling it stretches either one or both of its wings repeatedly. Apparently mothers spend most of the night inside the cave.

4T1 cell line was originally isolated by Fred Miller and colleagues as one of four sublines derived from the 410.4 tumor that was isolated from a single spontaneously arising mammary tumor.

In addition, expression of PDGFRα and -β correlated with invasive behavior in human mammary carcinomas. This indicates the numerous pathways through which autocrine signaling can regulate metastatic processes in a tumor.

It is known that this species is dependent on maternal care for the first couple of weeks after birth. Female forest dormice have eight mammary glands."The Dormouse Hollow." Dryomys. Web.

Removal should be with wide margins to prevent recurrence, taking the whole mammary gland if necessary. Because 40 to 50 percent of dog mammary tumors have estrogen receptors, spaying is recommended by many veterinarians. A recent study showed a better prognosis in dogs that are spayed at the time of surgery or that had been recently spayed. However, several other studies found no improvement of disease outcome when spaying was performed after the tumor had developed.

Cell death activator CIDE-A is a protein that in humans is encoded by the CIDEA gene. Cidea is an essential transcriptional coactivator regulating mammary gland secretion of milk lipids.Cidea is an essential transcriptional coactivator regulating mammary gland secretion of milk lipids This gene encodes the homolog of the mouse protein Cidea that has been shown to activate apoptosis. This activation of apoptosis is inhibited by the DNA fragmentation factor DFF45 but not by caspase inhibitors.

Netrin has been discovered to play a key role in the development and mature regulation of tissue outside the nervous system. Some of the non-neural tissues implicated include lung, placental, vasculature, pancreas, muscle and mammary gland tissue. Netrin contributes to tissue morphogenesis by controlling developing cell migration and cell adhesion in different organs. In developing mammary glands, the growing tips of the ductal network consist of two layers made up of luminal epithelial cells and cap cells.

Whereas free steroids like estradiol are lipophilic and can enter cells via passive diffusion, steroid conjugates like E1S are hydrophilic and are unable to do so. Instead, steroid conjugates require active transport via membrane transport proteins to enter cells. Studies in animals and humans have had mixed findings on uptake of exogenously administered E1S in normal and tumorous mammary gland tissue. This is in contrast to substantial uptake of exogenously administered estradiol and estrone by the mammary glands.

Like other placental mammals, cetaceans give birth to well- developed calves and nurse them with milk from their mammary glands. When suckling, the mother actively splashes milk into the mouth of the calf, using the muscles of her mammary glands, as the calf has no lips. This milk usually has a high fat content, ranging from 16 to 46%, causing the calf to increase rapidly in size and weight. In many small cetaceans, suckling lasts for about four months.

The TRPV6 protein is expressed in epithelial tissues such as the intestine, kidney, placenta, epididymis, and exocrine glands such as pancreas, prostate and salivary, sweat, and mammary glands. TRPV6 protein expression in humans has been demonstrated in the esophagus, stomach, small intestine, colon, pancreas, mammary glands, ovary, thyroid, and prostate by immunohistochemistry approaches. TRPV6 expression mainly confines on the apical membrane of epithelial cells. In the intestine, the protein is expressed on the brush- border membrane of enterocyte.

An illustration of mammary intercourse Mammary intercourse is a sex act, performed as either foreplay or as non-penetrative sex, that involves the stimulation of a man's penis by a woman's breasts and vice versa.Alex Comfort, The Joy of Sex (1972) p. 67-9 It involves placing the penis between a woman's breasts and moving the penis up and down to simulate sexual penetration and to create sexual pleasure. It may be used as an alternative to a handjob.

In a mouse specimen, when SIM2s was not expressed in mammary epithelial cells there were development defects leading to cancer-like characteristics in the cells. The defects were increased cell proliferation, cellular invasion of local stroma, loss of cellular polarity, and loss of E-cadherin cellular adhesion molecules. These observations suggest that SIM2s is essential for proper mammary gland development. Experiments reintroducing SIM2s in human breast cancer cells allowed for the tumor suppressive characteristics to be observed.

Radioactivity is also seen from uptake by the liver, and excretion and accumulation in the bladder. Extra-thyroidal iodine exists in several other organs, including the mammary glands, eyes, gastric mucosa, cervix, cerebrospinal fluid, arterial walls, ovary and salivary glands . In the cells of these tissues the iodide ion (I−) enters directly by the sodium-iodide symporter (NIS). Different tissue responses for iodine and iodide occur in the mammary glands and the thyroid gland of rats.

Whey Acidic Protein(WAP) is the major milk protein in certain mammals. There are exceptions in some mammalian species, whereby WAP has not been found to be synthesized in the mammary gland.

C1orf74 is ubiquitously expressed in most tissues in humans during embryonic development and through adulthood. This gene is expressed throughout the nervous system, mammary and salivary glands, skin, and most internal organs.

Baby tapirs of all types have striped- and-spotted coats for camouflage. Females have a single pair of mammary glands,Gorog, A. (2001). Tapirus terrestris, Animal Diversity Web. Retrieved June 19, 2006.

"Mammary mia!" -- findarticles.com. Retrieved 18 August 2007. During the process of choosing which celebrity to give a makeover, Constantine and Woodall compiled a list of who they thought were the worst dressed celebrities.

Males play an active role in lactation and feeding the young. They have mammary glands that are the same size as those of the female and exceed 8% of their overall body mass.

EMT suppression allows for E-cadherin to remain and for the cell to not undergo pathological EMT associated with tumor formation. These actions show the tumor suppressive effects of SIM2s in mammary epithelium.

RANK and RANKL have been reported to be expressed in some breast cancer and prostate cancer cell lines. RANKL expression in infiltrating T cells within mammary carcinomas activate RANK-expressing neoplastic mammary epithelial cells which stimulate metastasis. The expression of RANKL in these cells and the expression of RANK in bone cells may be the biological presentation of Paget’s seed and soil idea. The affinity for RANK of RANKL may be the reason these cancers tend to metastasize to bone.

Female cats and dogs are seven times more likely to develop mammary tumors if they are not spayed before their first heat cycle. The high dietary estrogen content of the average commercial pet food may be contributing factors in the development of mammary cancer, especially when these exogenous sources are added to those normal estrogens produced by the body. Dog food containing soybeans or soybean fractions have been found to contain phytoestrogens in levels that could have biological effects when ingested longterm.

In molecular biology, the Whey acidic proteins (WAP) have been identified as a major whey protein family in milk, and are important in regulating the proliferation of mammary epithelial cells. Additionally, their physiological function is thought to be similar to a protease inhibitor. It has been concluded, therefore, that WAP regulate the proliferation of mammary epithelial cells by preventing elastase-type serine proteases from carrying out laminin degradation and by suppressing the MAP kinase signal pathway in the cell cycle.

Several additional studies have found that eflornithine in combination with other compounds decreases the carcinogen concentrations of ethylnitrosourea, dimethylhydrazine, azoxymethane, methylnitrosourea, and hydroxybutylnitrosamine in the brain, spinal cord, intestine, mammary gland, and urinary bladder.

1824-1832 The PRLR has been found to be essential for lobuloalveolar maturation of the mammary glands during pregnancy, as evidenced by the fact that PRLR knockout mice show severely impaired development of lobuloalveolar structures.

1(4): 373-80. De Giovanni C, Nicoletti G, Landuzzi L, Palladini A, Lollini PL, Nanni P. "Bioprofiling TS/A Murine Mammary Cancer for a Functional Precision Experimental Model". Cancers (Basel). 2019 Nov 27;11(12).

Central duct excision is the surgical removal (excision) of all lactiferous duct under the nipple. The excision of a single duct is called microdochectomy, a mere incision of a mammary duct (without excision) is microdochotomy.

ADAM17 also regulates the MAP kinase signaling pathway by regulating shedding of the EGFR ligand amphiregulin in the mammary gland. ADAM17 also has a role in the shedding of L-selectin, a cellular adhesion molecule.

The production of phosphocholine from CK is necessary for the signal transduction pathways related to mitogenesis. It has also been found that CK plays a critical role in the proliferation of human mammary epithelial cells.

Ineffectiveness of doxorubicin treatment on solitary dormant mammary carcinoma cells or late-developing metastases. Breast Cancer Res Treat. 82:3, 199 – 206.Ranganathan A. C., Zhang L., Adam A. P., Aguirre- Ghiso J. A. (2006).

Mammary glands are most obvious in humans, as the female human body stores large amounts of fatty tissue near the nipples, resulting in prominent breasts. Mammary glands are present in all mammals, although they are seldom used by the males of the species. Most mammalian females have two copies of the X chromosome as opposed to males which have only one X and one smaller Y chromosome; some mammals, such as the platypus, have different combinations.Adrian T. Sumner, Chromosomes: Organization and Function (2008), pp.

Extramammary Paget’s Disease (EMPD), is a rare and slow-growing malignancy which occurs within the epithelium and accounts for 6.5% of all Paget’s disease. The clinical presentation of this disease is similar to the characteristics of mammary Paget’s disease (MPD). However, unlike MPD, which occurs in large lactiferous ducts and then extends into the epidermis, EMPD originates in glandular regions rich in apocrine secretions outside the mammary glands. EMPD incidence is increasing by 3.2% every year, affecting hormonally-targeted tissues such as the vulva and scrotum.

Methylselenocysteine, also known as Se-methylselenocysteine, is an analog of S-methylcysteine in which the sulfur atom is replaced with a selenium atom. It is an inhibitor of DMBA-induced mammary tumors and a "chemopreventive agent that blocks cell cycle progression and proliferation of premalignant mammary lesions and induces apoptosis of cancer cell lines in culture." Apoptosis has been proposed as the most plausible mechanism for the chemopreventive activities of selenocompounds. Se-Methylselenocysteine was more efficient at inducing apoptosis than selenite, but was less toxic.

Most mammary tumors in mice are adenocarcinomas. They can be caused by viral infection. Recurrence rates are high, and therefore there is a poor prognosis. There is frequently local tissue invasion and metastasis to the lungs.

The EGFR is essential for ductal development of the mammary glands, and agonists of the EGFR such as amphiregulin, TGF-α, and heregulin induce both ductal and lobuloalveolar development even in the absence of estrogen and progesterone.

Histologically, the inframammary fold is an intrinsic dermal structure consisting of regular arrays of collagen held in place by a specialized superficial fascia system. The fold is formed by the fusion of the superficial and mammary fasciae.

For example, there may be critical differences between cancer pathogenesis in mice and people. A human homologue of the mammary virus has been described in 1971 and linked to human breast cancer in several small epidemiologic studies.

KLK9 belongs to the kallikrein subgroup of serine proteases, which have diverse physiologic functions in many tissues. KLK9 is primarily expressed in thymus, testis, spinal cord, cerebellum, trachea, mammary gland, prostate, brain, salivary gland, ovary, and skin.

Mammaglobin is a gene that encodes a 10-kilodalton glycoprotein. In humans expression of the gene is limited to the adult mammary gland, a correlation between increased expression of the gene and breast cancer has been reported.

Dry periods that are too short have been associated with reduced milk yields and increased risks of infections. Dry periods that are too long have also been linked to an overall decrease in lifetime milk yields but could also lead to over-conditioning, metabolic diseases and infections. During this time the cow is highly susceptible to intra-mammary infections due to the anatomical and functional changes occurring within the mammary gland. Proper individualized treatments and management must be implemented for optimal health and production as well as disease prevention.

Estrogen stimulation of ERα is known to stimulate cell proliferation in breast tissue. ERα is thought to be responsible for pubertal development of the adult phenotype, through mediation of mammary gland response to estrogens. This role is consistent with the abnormalities of female ERKO mice: the epithelial ducts of female ERKO mice fail to grow beyond their pre-pubertal length, and lactational structures do not develop. As a result, the functions of the mammary gland—including both lactation and release of prolactin—are greatly impaired in ERKO mice.

In animals with udders, the mammary glands develop on the milk line near the groin, and mammary glands that develop on the chest (such as in humans and apes) are generally referred to as breasts. Udder care and hygiene in cows is important in milking, aiding uninterrupted and untainted milk production, and preventing mastitis. Products exist to soothe the chapped skin of the udder. This helps prevent bacterial infection, and reduces irritation during milking by the cups, and so the cow is less likely to kick the cups off.

PTHrP acts as an endocrine, autocrine, paracrine, and intracrine hormone. It regulates endochondral bone development by maintaining the endochondral growth plate at a constant width. It also regulates epithelial–mesenchymal interactions during the formation of the mammary glands.

There are short hairs on the lower sides of the interdigital webs. The four-lobed plantar pads are longer than wide. The claws are short, almost erect, and in some individuals even absent. Females have four mammary glands.

Trichinella is the smallest human nematode parasite, yet it is also the largest of all intracellular parasites. Oral ingestion of larvae-contaminated tissue is the usual route of infection, but congenital and mammary transmission can occur in rats.

67 (Suppl. 1): 467.Mollett, T. A., C. B. Brooks and E. A. Leighton. 1988. Milk quality, composition and isolation of microorganisms from the mammary gland of the dam associated with reduced calf weaning weight in beef cattle.

Effects of estramustine phosphate (Estracyt) on growth of DMBA-induced mammary tumors in rats. In Acta Pharmacologica et Toxicologica (Vol. 35, pp. 28-28). 35 Norre Sogade, PO Box 2148, DK-1016 Copenhagen, Denmark: Munksgaard Int Publ Ltd.

Atypical hyperplasia is a high-risk premalignant lesion of the breast. It is believed that atypical ductal hyperplasia (ADH) is a direct precursor for low- grade mammary ductal carcinoma, whereas atypical lobular hyperplasia (ALH) serves as a risk indicator.

David S. Salomon, Ph.D. (born 1947) is a cancer research scientist and co- discoverer of the Cripto-1 gene. His areas of research include stem cells, cell signaling, breast cancer, mammary gland development, small molecule inhibitors, and embryonic development.

In the absence of specific markers for mammary cells, models with genetic marking of tumor cells gives the best experimental advantage, however the low volume of peripheral blood that can be obtained from live animals limits the application of this technique.

Some marsupials (e.g. phascogales) lack the true, permanent pouches seen in other species. Instead, they form temporary skin folds (sometimes called "pseudo- pouches") in the mammary region when reproducing. This type of pouch also occurs in monotremes (platypus and echidnas).

Zumpt I. F. 1970. "The ground squirrel", African Wild Life 24:115-121. The belly and groin area of the females each have two pairs of mammary glands. The glans penis of the males are large with a prominent baculum.

CD133 is expressed in hematopoietic stem cells, endothelial progenitor cells, glioblastoma, neuronal and glial stem cells, various pediatric brain tumors, as well as adult kidney, mammary glands, trachea, salivary glands, uterus, placenta, digestive tract, testes, and some other cell types.

Estrogens can be used to suppress and cease lactation and breast engorgement in postpartum women who do not wish to breastfeed. They do this by directly decreasing the sensitivity of the alveoli of the mammary glands to the lactogenic hormone prolactin.

Cancer Res. 2016;76:5994-6005. mammary,Demaria S, Kawashima N, Yang AM, et al. “Immune-mediated inhibition of metastases after treatment with local radiation and CTLA-4 blockade in a mouse model of breast cancer. Clin Cancer Res. 2005;11:728‐734.

In endothelial cells and mammary epithelial cells, the stimulatory effect of IGFBP-3 has been shown to involve activation of the enzyme sphingosine kinase, and generation of the bioactive lipid, sphingosine-1-phosphate, which promotes growth by transactivating the EGFR receptor.

AGR2 may help regulate the protein and mRNA levels in a cell overall as well. During late pregnancy and lactation, AGR2 levels peak when milk proteins are produced, and mammary-specific Agr2 knockout mice had downregulated milk protein mRNA expression.

The hind feet are narrow and the slender tail is clad with short hairs, and often has a white tip. There are three pairs of mammary glands. The chief differences between the two species lies in the morphology of the skull.

2-Tolidine is toxic and possibly carcinogenic. It is listed as an IARC Group 2B carcinogen, meaning it is "possibly carcinogenic to humans". Animal studies have shown that animals exposed to tolidine developed tumors in the liver, kidney, and mammary glands.

Male cats may also develop mammary adenocarcinoma, albeit rarely, and the clinical course is similar to female cats. As in dogs, tumor size is an important prognostic factor, although for tumors less than three centimeters the individual size is less predictive. According to one study, cats with tumors less than three cm had an average survival time of 21 months, and cats with tumors greater than three cm had an average survival of 12 months. About 10 percent of cat mammary tumors have estrogen receptors, so spaying at the time of surgery has little effect on recurrence or survival time.

In approximately 70% of diagnosed cases of breast cancers, the ER activity is over expressed. Growing exposure of the mammary epithelium to estrogen is related to risk of breast cancer as the binding of estrogen to the HER2 (cancerous breast cell receptor) in mammary cells causes a rise in division and cell synthesis. This ultimately leads to a higher risk of replication errors, and the disruption of the normal cellular processes result in errors in apoptosis, cellular proliferation, or DNA repair. The ERT has been suggested as a predictor for the level of success of use of endocrine therapy in cancer treatment.

Living mammal species can be identified by the presence in females of mammary glands which produce milk. Other features are required when classifying fossils, since mammary glands and other soft-tissue features are not visible in fossils. Paleontologists therefore use the ossicles as distinguishing bony features shared by all living mammals (including monotremes), but is not present in any of the early Triassic therapsids ("mammal-like reptiles"). left Early amniotes had a jaw joint composed of the articular (a small bone at the back of the lower jaw) and the quadrate (a small bone at the back of the upper jaw).

69, 175 and 176Margo Ananad, The Art of Sexual Ecstasy (1990) p. 309 Since mammary intercourse is a non- penetrative sex act, the risk of passing a sexually transmitted infection (STI) that requires direct contact between the mucous membranes and pre- ejaculate or semen is greatly reduced. HIV is among the infections that require such direct contact and is therefore very unlikely to be transmitted via mammary intercourse. A study of the condom usage habits of New Zealand's sex workers said that they offered various safe sex alternatives to vaginal sex to clients who refused to wear a condom.

Ulnar–mammary syndrome or Schinzel syndrome is a cutaneous condition characterized by nipple and breast hypoplasia or aplasia.Schinzel Syndrome Features of UMS can be mild to severe and can vary significantly from person to person, even within the same family. The main features of UMS include upper limb defects (including abnormal or incomplete development of the fingers and forearm), underdevelopment of the apocrine and mammary glands (leading to absent breast development and the inability to produce breast milk), and various genital abnormalities. Other signs and symptoms may include hormonal deficiencies, delayed puberty (particularly in males), dental problems and obesity.

Majewska H, Skálová A, Stodulski D, Klimková A, Steiner P, Stankiewicz C, Biernat W. "Mammary analogue secretory carcinoma of salivary glands: a new entity associated with ETV6 gene rearrangement." Virchows Arch. 2015 Mar;466(3):245-54. doi: 10.1007/s00428-014-1701-8.

Past Mammary Lane episodes are airing currently on Howard 101 in afternoon drivetime, 3-7 PM Eastern time, the time of day in which Bubba the Love Sponge had been broadcasting on Howard 101 prior to leaving Sirius due to unsuccessful contract negotiations.

The vulva is the external opening of the vagina, and consists of the clitoris and two labia. It lies ventral to the rectum. The mare has two mammary glands, which are smaller in maiden mares. They have two ducts each, which open externally.

However, it would not have possessed mammary glands, and would have fed its young, as birds do, on regurgitated food. He speculated that its language would have sounded somewhat like bird song.Naish, D. (2006). Dinosauroids Revisited Darren Naish: Tetrapod Zoology, April 23, 2011.

Sir Astley Paston Cooper, 1st Baronet (23 August 176812 February 1841) was an English surgeon and anatomist, who made historical contributions to otology, vascular surgery, the anatomy and pathology of the mammary glands and testicles, and the pathology and surgery of hernia.

The breasts are apocrine glands which produce milk for the feeding of infant children,Tortora, Gerard J. Introduction to the Human Body, Fifth Edition. John Wiley & Sons, Inc.: New York, 2001. p. 560. Breast augmentation: cross-section scheme of the mammary gland.

Prolactin is responsible for the behaviours seen during pseudopregnancy. Dogs may exhibit mothering of toys, nesting or aggression. Mammary development and milk production are common. Pseudopregnancy can also be acutely induced by spaying (removing of ovaries) a dog near the end of estrus.

Breeding receptivity in the yellow-bellied sheath-tailed bat begins in August when the right uterine horn increases in diameter, achieving maximum size in November. A single offspring is produced between December and March, with mammary glands regressing by the end of May.

In 1939 Fieschi introduced internal mammary ligation as a procedure to improve blood flow to the heart. Not until a controlled study was done two decades later could it be demonstrated that the procedure was only as effective as the sham surgery.

Cancer cell. 2008 Sep 9;14(3):238-49.Liu S, Dontu G, Mantle ID, Patel S, Ahn NS, Jackson KW, Suri P, Wicha MS. Hedgehog signaling and Bmi-1 regulate self- renewal of normal and malignant human mammary stem cells. Cancer research.

LPL is attached to the luminal surface of endothelial cells in capillaries by the protein glycosylphosphatidylinositol HDL-binding protein 1 (GPIHBP1) and by heparan sulfated peptidoglycans. It is most widely distributed in adipose, heart, and skeletal muscle tissue, as well as in lactating mammary glands.

Decreased health in the new born calf will negatively impact the quality of the replacement herd. There is also evidence that increased rates of mammary cell proliferation occur during the dry period that is essential to maintaining high production levels in subsequent lactation cycles.

Mammary health in the animals themselves has improved over this time period as well as the overall health of the dairy herd in general. This is mostly attributed to better application methods of rBST and a better understanding of how the hormone affects the animals.

Microarray and EST data indicates that the DHRS7B gene is highly expressed in the testes, thyroid, kidneys, and adipose tissues. There is moderate expression in the brain, pancreas, mammary glands, and ovaries. Finally, there is little expression in spleen, thymus, tonsils, bone marrow, and bladder.

The mouse counterpart of this gene is found to induce the expression of BCL2L1/BCL-X(L), which suggests the antiapoptotic function of this gene in cells. It also transduces prolactin signals to the milk protein genes and is necessary for mammary gland development.

Leptin is produced primarily in the adipocytes of white adipose tissue. It also is produced by brown adipose tissue, placenta (syncytiotrophoblasts), ovaries, skeletal muscle, stomach (the lower part of the fundic glands), mammary epithelial cells, bone marrow,gastric chief cells and P/D1 cells.

Overexpression of this gene in mammary epithelial cells leads to sensitization of the cells to epidermal growth factor and results in a partially transformed phenotype. Expression of this gene has been detected at low levels in some breast tumors but not in normal breast tissue.

The lymphatic drainage of the breasts is especially relevant to oncology because breast cancer is common to the mammary gland, and cancer cells can metastasize (break away) from a tumour and be dispersed to other parts of the body by means of the lymphatic system.

Proteins that are capable of enhancing the identification of labeled cells or a specific population in unlabelled cells are encoded by the reporter transgenes. After harvesting all the ten mouse mammary glands from the transgenic mice, single cell suspension is usually made and transplanted either in tail vein of non transgenic recipient mice or in cleared fat pad of non-transgenic mice repopulating the mammary fat pad. These cells are then followed in the blood stream, lungs, bone marrow and liver to look for the favorable site of metastasis.these transgenic cells can be traced according to their special features of either fluorescence or induced by placing the recipients on doxycycline food.

This latter prediction, however, contradicted the in vivo data; irradiation of adult mammary glands did not lead to increased stem cell frequency. These simulations therefore suggested self-renewal as the primary mechanism behind pubertal stem cell increase. To further evaluate self-renewal as the mechanism, a second agent-based model was created to simulate the growth dynamics of human mammary epithelial cells (containing stem/progenitor and differentiated cell subpopulations) in vitro after irradiation. By comparing the simulation results with data from the in vitro experiments, the second agent-based model further confirmed that cells must extensively proliferate to observe a self-renewal dependent increase in stem/progenitor cell numbers after irradiation.

Lysozyme in donkey milk is present in large amounts, indeed ranges from 1.0 mg/mL to 4 mg/mL, depending on the analytical method used (chemical or microbiological); this substance is present also in human (0.12 mg/ml) but only in trace amounts in cow and goat milk. Lysozyme in donkey milk is highly thermo-stable and is very resistant to acid and protease and may play a significant role in the intestinal immune response. In donkey mammary secretion, defatted or not, growth factors and hormones have also been determined. In detail, donkey mammary secretions contain human-like leptin at levels close to human milk (3.35 e 5.32 ng/mL milk).

Cell counts begin at a moderate number, increase during the first part of the lactation, then decrease as the lactation proceeds. Once lost, these cells generally do not regrow until the next lactation. Administration of rBST or BST prior to peak production, in cows that are well- fed, slows the rate at which the number of mammary cells decreases, and increases the amount of nutrients directed away from fat and toward the mammary cells, leading to an extension of peak milk production. The effects are mediated by the insulin-like growth factor (IGF) system, which is upregulated in response to BST or rBST administration in well-fed cows.

Arzoxifene (; developmental code name LY-353381) is a selective estrogen receptor modulator (SERM) of the benzothiophene group which was never marketed. It is a potent estrogen antagonist in mammary and uterine tissue while acting as an estrogen agonist to maintain bone density and lower serum cholesterol. Arzoxifene is a highly effective agent for prevention of mammary cancer induced in the rat by the carcinogen nitrosomethylurea and is significantly more potent than raloxifene in this regard. Arzoxifene is devoid of the uterotrophic effects of tamoxifen, suggesting that, in contrast to tamoxifen, it is unlikely that the clinical use of arzoxifene will increase the risk of developing endometrial carcinoma.

54 no. 1 106-113 Staphylococcus caprae was first described in 1983 by Devisee et al. based on a strain isolated from some goat milk. It can sometimes cause mastitis in the goats, and it is considered a commensal organism for the goats’ skin and mammary glands.

Metastasis tends to be to the lungs and lymph nodes, and rarely to bone. Diagnosis and treatment is similar to the dog. There is a better prognosis with bilateral radical surgery (removing both mammary chains) than with more conservative surgery. Doxorubicin has shown some promise in treatment.

State Premier Nathan Rees dismissed Noreen Hay from her position as Parliamentary Secretary for Health on 12 September 2008 after allegations arose that she participated in simulated mammary intercourse with Police Minister Matt Brown at an office party in June. Both Brown and Hay denied the allegations.

A human baby is nearly helpless and the growing child requires high levels of parental care for many years. One important type of early parental care is lactation, feeding the baby milk from the mother's mammary glands in her breasts.Sexual Reproduction in Humans. 2006. John W. Kimball.

Tibullus observes that a woman just might wear loose clothing so that her breasts "flash" when she reclines at dinner.Tibullus 1.6.18; Dalby, Empire of Pleasures, p. 263. An astrological tradition held that mammary intercourse was enjoyed by men born under the conjunction of Venus, Mercury, and Saturn.

Mammary (breast) cancer on a dog. Mast cell tumor on dog. Veterinary pathologists are veterinarians who specialize in the diagnosis of diseases through the examination of animal tissue and body fluids. Like medical pathology, veterinary pathology is divided into two branches, anatomical pathology and clinical pathology.

In human anatomy, the internal thoracic vein (previously known as the internal mammary vein) is a vessel that drains the chest wall and breasts. Bilaterally, it arises from the superior epigastric vein, accompanies the internal thoracic artery along its course and terminates in the brachiocephalic vein.

It is located in mitochondria of several tissues in the body, with most abundance in the kidney and prostate. It may be found at lower levels in macrophages, lactating mammary glands, and brain. The second isozyme may be found in the absence of other urea cycle enzymes.

Spayed female dogs are less likely to develop cancer, affecting mammary glands, ovaries, and other reproductive organs. However, neutering increases the risk of urinary incontinence in female dogs, and prostate cancer in males, and osteosarcoma, hemangiosarcoma, cruciate ligament rupture, obesity, and diabetes mellitus in either sex.

The incidence of mammary desmoid tumours is less than 0.2% of primary breast neoplasms. In Gardner’s syndrome the incidence ranges from 4% to 17%. Desmoid tumours associated with Gardner’s syndrome have been shown to have an alteration of the β-catenin pathway and over express β-catenin.

The mammary glands and genitals of pinnipeds can retract into the body. Pinnipeds range in size from the and Baikal seal to the and southern elephant seal. Overall, they tend to be larger than other carnivorans; the southern elephant seal is the largest carnivoran.Berta, A. "Pinnipedia, overview", pp.

Rats were fed PhIP at concentrations of 25, 100, and 200 ppm. The rats gained weight throughout the experiment, but feeding concentration of PhIP remained constant. Rats were fed PhIP ad libitum at concentrations of 12.5 and 50ppm. Rats developed mammary tumors at each concentration of PhIP administered.

TMEM205 has been shown to be expressed in greater amounts in tissues that have secretory function. These tissues include the thyroid, adrenal gland, pancrease, and mammary tissues. The protein has also been shown to have increased expression in tumor tissue that have become resistant to platinum based chemotherapy drugs.

Environmental conditions such as ventilation and temperature should be considered. Managing heat stress can be implemented through the use of shade and water sprinklers. Research has shown that heat stress during this period can compromise the immune system, reduce mammary tissue development and reduce milk production following lactation.

Braun-Menedez, J.C. Fasciolo, L.F. Leloir, J.M. Muñoz)The Journal of Physiology(1940) no.98 pg.283-298 That same year, his colleague Ranwel Caputto, in his investigations of the mammary gland, made discoveries regarding carbohydrate storage and its subsequent transformation into a reserve energy form in organisms.

The underparts are paler than the back fur. The majority of species have long, soft fur, but the woolly and lesser woolly horseshoe bats (R. luctus and R. beddomei) are unusual in their very long, woolly fur. Like most bats, horseshoe bats have two mammary glands on their chests.

Members of the IGF receptor family and their ligands also seem to be involved in the carcinogenesis of mammary tumors of dogs. IGF1R is amplified in several cancer types based on analysis of TCGA data, and gene amplification could be one mechanism for overexpression of IGF1R in cancer.

This occurs in around 10% of cases. The mammary glands are also controlled by the pituitary gland, so lactation can also be affected. The pituitary gland is controlled by the hypothalamus. In 10% of cases, alterations in the chemical signals from the hypothalamus can easily seriously affect the ovaries.

Also known as the systemic arch. The fourth right arch forms the right subclavian as far as the origin of its internal mammary branch. The fourth left arch forms the arch of the aorta between the origin of the left carotid artery and the terminus of the ductus arteriosus.

She then completed graduate studies at McGill in the Department of Genetics under Charles Leonard Huskins. Her Ph.D. thesis was The correlation between chromosome behaviour and susceptibility to mammary gland cancer in mice (1938), for which she won the Governor General's Academic Medal for graduate work in science.

Based on the EST profile, CORO6 expressed in high level at the larynx, nerve and muscle. CORO6 has also been shown to be expressed in high levels in the breast (mammary gland) tumor. During the human development stage, the higher level of CORO6 expressed at blastocyst and adult.

In human anatomy, the lateral thoracic artery (or external mammary artery) is a blood vessel that supplies oxygenated blood to the lateral structures of the thorax and breast. It originates from the axillary artery and follows the lower border of the Pectoralis minor muscle to the side of the chest, supplies the Serratus anterior muscle and the Pectoralis major muscle, and sends branches across the axilla to the axillary lymph nodes and Subscapularis muscle. It anastomoses with the internal thoracic artery, subscapular, and intercostal arteries, and with the pectoral branch of the thoracoacromial artery. In the female it supplies an external mammary branch which turns round the free edge of the Pectoralis major and supplies the breasts.

At the same time in Germany, Hansjörg Eibl, at the Max Planck Institute for Biophysical Chemistry, and Clemens Unger, at the University of Göttingen, demonstrated that the antineoplastic activity of the phospholipid analogue miltefosine (at the time known as hexadecylphosphocholine) was indeed tumour- specific. It was highly effective against methylnitrosourea-induced mammary carcinoma, but less so on transplantable mammary carcinomas and autochthonous benzo(a)pyrene-induced sarcomas, and relatively inactive on Walker 256 carcinosarcoma and autochthonous acetoxymethylmethylnitrosamine-induced colonic tumors of rats. It was subsequently found that miltefosine was structurally unique among lipids having anticancer property in that it lacks the glycerol group, is highly selective on cell types and acts through different mechanism.

Plasma FGF21 was similarly increased in the absence of parturition when an energy-deficit state was induced by feed restricting late- lactating dairy cows, implicating energy insufficiency as a cause of chronically elevated FGF21 in EL. The liver was the major source of plasma FGF21 in early lactation with little or no contribution by WAT, skeletal muscle, and mammary gland. Meaningful expression of the FGF21 coreceptor β-Klotho was restricted to liver and WAT in a survey of 15 tissues that included the mammary gland. Expression of β-Klotho and its subset of interacting FGF receptors was modestly affected by the transition from LP to EL in liver but not in WAT.

During the dry period (late gestation, non-lactating), dairy cattle have relatively low calcium requirements, with a need to replace approximately 30 g of calcium per day due to utilization for fetal growth and fecal and urinary losses. At parturition, the requirement for calcium is greatly increased due to initiation of lactation, when mammary drainage of calcium may exceed 50g per day. Due to this large increase in demand for calcium, most cows will experience some degree of hypocalcemia for a short period following parturition as the metabolism adjusts to the increased demand. When the mammary drain of plasma calcium causes hypocalcemia severe enough to compromise neuromuscular function, the cow is considered to have clinical milk fever.

In 1966, during its clinical development, ethynerone was found to produce mammary gland tumors in dogs treated with it at very high doses for prolonged periods of time. Subsequent investigation found that 17α-hydroxyprogesterone derivatives included anagestone acetate, chlormadinone acetate, medroxyprogesterone acetate, and megestrol acetate produced similar mammary gland tumors, and that their ability to do so correlated directly with their progestogenic actions. In contrast, the non-halogenated 19-nortestosterone derivatives norgestrel, norethisterone, noretynodrel, and etynodiol diacetate, which are much less potent as progestogens, did not produce such effects at the dosages tested. Clinical development of ethynerone was discontinued, and many of the 17α-hydroxyprogesterone derivatives were withdrawn for the indication of hormonal contraception.

Keith Henry Stockman Campbell (23 May 1954 – 5 October 2012) was a British biologist who was a member of the team that in 1996 first cloned a mammal, a Finnish Dorset lamb named Dolly, from fully differentiated adult mammary cells. He was Professor of Animal Development at the University of Nottingham.

Mice genetically altered to delete Sirt3 develop estrogen and progesterone receptor (ER/PR) positive breast mammary tumors. In tumor samples from women with breast cancer, SIRT3 expression was decreased, as compared to normal breast tissues. Thus, the Sirt3 knockout model may be used to investigate ER/PR positive breast tumor development.

Cefacetrile (INN, also spelled cephacetrile) is a broad-spectrum first generation cephalosporin antibiotic effective in gram-positive and gram- negative bacterial infections. It is a bacteriostatic antibiotic. Cefacetrile is marketed under the trade names Celospor, Celtol, and Cristacef, and as Vetimast for the treatment of mammary infections in lactating cows.

Research later on revealed species differences between dogs and humans and established that there is no similar risk in humans. Mammary tumors in beagle dogs treated by (left) MK-665 (ethynerone with mestranol) and (right) chloroethynylnorgestrel with mestranol for 4 years at a dosage of 1.05 mg/kg/day cyclically.

The International Agency for Research on Cancer and the National Toxicology Program have labeled benzene as a definite human carcinogen. Multiple studies point to a correlation between benzene exposure and breast cancer risk. Laboratory studies on mice have shown that a high level of benzene exposure can lead to mammary cancer.

The expression levels of TTC39A found throughout the human body There are 17 splice variants for TTC39A. TTC39A is a highly expressed protein in the human body. The highest levels of expression are located in mammary glands and testis. The lowest levels of expression are found in the immune system.

The mammary gland is thought to have derived from apocrine skin glands. It has been suggested that the original function of lactation (milk production) was keeping eggs moist. Much of the argument is based on monotremes (egg-laying mammals). The original adaptive significance of milk secretions may have been nutrition or immunological protection.

The cells were derived from the pleural effusion of a ductal carcinoma found in the mammary gland of an elderly human patient. T-47D cells are distinct from other human breast cancer cells in that their progesterone receptors are not regulated by estradiol, a hormone that is abundant within the cells themselves.

Abnormal function of Syk has been implicated in several instances of hematopoietic malignancies including translocations involving Itk and Tel. Constitutive Syk activity can transform B cells. Several transforming viruses contain "Immunoreceptor Tyrosine Activation Motifs" (ITAMs) which lead to activation of Syk including Epstein Barr virus, bovine leukemia virus, and mouse mammary tumor virus.

The MTA3-NuRD complex represses Snail, a master regulator of epithelial-to-mesenchymal transition (EMT), Wnt4 expression in mammary epithelial cells, and BCL6-corepressor target genes The MTA3-NuRD complex interacts with GATA3 to regulate the expression of GATA3 downstream targets. In addition, MTA3 upregulates HIF1 and its transactivation activity in hypoxic conditions.

PTPkappa is expressed in human keratinocytes. TGFβ1 is a growth inhibitor in human keratinocytes. Stimulation of the cultured human keratinocyte cell line, HaCaT, with TGFβ1 increases the levels of PTPkappa (PTPRK) mRNA as assayed by northern blot analysis. TGFβ1 also increased PTPkappa mRNA and protein in normal and tumor mammary cell lines.

RANKL is expressed in several tissues and organs including: skeletal muscle, thymus, liver, colon, small intestine, adrenal gland, osteoblast, mammary gland epithelial cells, prostate and pancreas. Variation in concentration levels of RANKL throughout several organs reconfirms the importance of RANKL in tissue growth (particularly bone growth) and immune functions within the body.

In ICD-10 the condition is called diffuse cystic mastopathy, or, if there is epithelial proliferation, fibrosclerosis of breast.Disorders of breast (N60-N64) in ICD-10. Other names for this condition include chronic cystic mastitis, fibrocystic mastopathy and mammary dysplasia. The condition has also been named after several people (see eponyms below).

The human mammary gland provides the baby with a unique fat composition where the fatty acids arranged in specific combinations, different from the triglycerides in other human tissues and plasma,Breckenridge, W.C., L. Marai, and A. Kuksis, Triglyceride structure of human milk fat. Can J Biochem, 1969. 47(8): p. 761-9.

2-meOE2 appeared to be able to halve the basal aromatase activity in mammary fibroblasts, possibly through destabilisation of the microtubules that mediate translocation of the cytokine receptors to the plasma membrane. Inhibition of cytokine receptor synthesis and blockade of the autocrine and paracrine actions of cytokines and PGE2 were also observed.

Breeder costs consist of prenatal care, postnatal care and maintenance of breeding status. Prenatal care is the amount of maternal investment during fetus gestation and postnatal care is the investment following birth. Examples of prenatal care are fetal, placentae, uterus and mammary tissue development. Postnatal examples are lactation, food provisions and guarding behavior.

This trilayer is collectively known as MFGM. This secretion process occurs in all types of mammalian milk, including human and bovine. However, it is distinct from the lipid secretion mechanism used by all other non-mammary cells. That makes MFGM unique to milk and it is not present in non-dairy food products.

Lagomorphs are similar to other mammals in that they all have hair, four limbs (i.e., they are tetrapods), and mammary glands and are endotherms. Lagomorphs possess a moderately fused postorbital process to the cranium, unlike other small mammals. They differ in that they have a mixture of "primitive" and "advanced" physical traits.

According to the National Center for Biotechnology Information, C2CD4D has only been found to be expressed in adult individuals with some form of cancer.National Center for Biotechnology Information C2CD4D is not ubiquitously expressed, and thus far scientists have only found C2CD4D expressed in the tissues of the brain, intestine, and mammary gland.

File:GEO Profile of A1BG tissue expression.jpg#filelinks A1BG is expressed at high levels in the adult and fetal liver. Additionally, the mammary gland shows roughly half as much expression as the liver. Trace amounts of A1BG expression can be found in the blood, brain, lung, lymph node, ovary, testis, pancreas, and pancreas.

This dynamic affirms the consensus among researchers that human milk evolved to provide not only nutritional but immunological benefits to the infant. Some researches have proposed that the mammary gland and milk production evolved as a part of the human innate immune system, with its immunological protective role predating its nutritional role.

VDR knockout mice show more extensive ductal development relative to wild-type mice, as well as precocious mammary gland development. In addition, VDR knockout has also been shown to result in increased responsiveness of mouse mammary gland tissue to estrogen and progesterone, which was represented by increased cell growth in response to these hormones. Conversely however, it has been found that VDR knockout mice show reduced ductal differentiation, represented by an increased number of undifferentiated TEBs, and this finding has been interpreted as indicating that vitamin D may be essential for lobuloalveolar development. As such, calcitriol, via the VDR, may be a negative regulator of ductal development but a positive regulator of lobuloalveolar development in the mammary gland. A possible mechanism of the negative regulatory effects of the VDR on breast development may be indicated by a study of vitamin D3 supplementation in women which found that vitamin D3 suppresses cyclooxygenase-2 (COX-2) expression in the breast, and by doing so, reduces and increases, respectively, the levels of prostaglandin E2 (PGE2) and transforming growth factor β2 (TGF-β2), a known inhibitory factor in breast development.

BrdU pulse/chase experiments with these cells demonstrated that chromosomes segregated non-randomly only when the cells were induced to divide asymmetrically like adult stem cells. These asymmetrically dividing cells provide an in vitro model for demonstration and investigation of immortal strand mechanisms. Scientists have strived to demonstrate that this immortal DNA strand mechanism exists in vivo in other types of adult stem cells. In 1996 Nik Zeps published the first paper demonstrating label retaining cells were present in the mouse mammary gland and this was confirmed in 2005 by Gilbert Smith who also published evidence that a subset of mouse mammary epithelial cells could retain DNA label and release DNA label in a manner consistent with the immortal DNA strand mechanism.

The luminal cells secrete netrin 1, which binds to the receptor neogenin (a homologue of DCC) on the cap cells. This allows for adhesion between the two cell layers, which is necessary for the proper morphogenesis of the terminal end buds (TEBs) in the mammary glands. Loss of the gene coding for either netrin 1 or neogenin leads to the improper formation of the (TEBs), suggesting that rather than acting as a guidance molecule as in neuronal systems, netrin 1 serves as an adhesive in mammary tissue. During the morphogenesis of the embryonic lung, epithelial cells express netrin 1 and netrin 4. These netrins surround endoderm buds in the basement membrane, preventing distal tip cells from expressing DCC and UNC5B.

The choice of is highly dependent upon the particular surgeon and institution. Typically, the left internal thoracic artery (LITA) (previously referred to as left internal mammary artery or LIMA) is grafted to the left anterior descending artery and a combination of other arteries and veins is used for other coronary arteries. The great saphenous vein from the leg is used approximately in 80% of all grafts for CABG. The right internal thoracic (mammary) artery (RITA or RIMA) and the radial artery from the forearm are frequently used as well; in the U.S., these vessels are usually harvested either endoscopically, using a technique known as endoscopic vessel harvesting (EVH), or with the open-bridging technique, employing two or three small incisions.

Human ALOX15 protein is highly expressed in circulating blood eosinophils and reticulocytes, cells, bronchial airway epithelial cells, mammary epithelial cells, the Reed-Sternberg cells of Hodgkin's lymphoma, corneal epithelial cells, and dendritic cells; it is less strongly expressed in alveolar macrophages, tissue mast cells, tissue fibroblasts, circulating blood neutrophils, vascular endothelial cells, joint Synovial membrane cells, seminal fluid, prostate epithelium cells, and mammary ductal epithelial cells. The distribution of Alox15 in sub-human primates and, in particular, rodents differs significantly from that of human ALOX15; this, along with their different principal product formation (e.g. 12-HETE rather than 15-HETE) has made the findings of Alox15 functions in rat, mouse, or rabbit models difficult to extrapolate to the function of ALOX15 in humans.

It harbors a regulatory DNA sequence called the long terminal repeat (LTR), which promotes steroid- hormone-inducible transcription. Tumorgenesis that was induced by the mouse mammary tumor virus can also be done by integration of the viral genome. The sites of integration have been known to be critical genes for cellular regulation.Ross, RS. (2010).

The majority of deaths were caused by neoplasms, mainly mammary tumors. The Siamese also has a higher rate of morbidity. They are at higher risk of neoplastic and gastrointestinal problems but have a lower risk of feline lower urinary tract disease. Vet clinic data from England shows a higher median lifespan of 14.2 years.

Lactoperoxidase is a peroxidase enzyme secreted from mammary, salivary, and other mucosal glands that functions as a natural antibacterial agent. Lactoperoxidase is a member of the heme peroxidase family of enzymes. In humans, lactoperoxidase is encoded by the LPO gene. Lactoperoxidase catalyzes the oxidation of a number of inorganic and organic substrates by hydrogen peroxide.

Expression Levels found in Leukemia It is also found to be highly expressed in breast (mammary gland) tumor, cervical tumor, esophageal tumor, leukemia, liver tumor; lung tumor, pancreatic tumor, prostate cancer, and soft tissue/muscle tissue tumor. TMEM106C is found in all stages of development from embryoid body, blastocyst, fetus, infant, juvenile and adult.

NCBI GEO Profiles detailed several conditions under which NHLRC2 expression is increase in comparison to base expression levels. Many, but not all, conditional cases involved an increase of NHLRC2 expression in various cancer types, including—but not limited to—the following: leukemia, lymphomas, breast & mammary gland cancer, colorectal cancer, Wilms' tumor, and lung cancer.

These include lacrimal, parotid, submaxillary, sublingual, preputial and mammary glands. In some species, such as cats and pigs, Mups appear not to be expressed in urine at all and are mainly found in saliva. Sometimes the term urinary Mups (uMups) is used to distinguish those Mups expressed in urine from those in other tissues.

That work predated clinical application of the same concept in human breast cancer by several decades.Galante M, McCorkle HJ: Clinical evaluation of bilateral adrenalectomy and oophorectomy for advanced mammary carcinoma. Am J Surg 1955; 90: 180-188. In 1915, Loeb was appointed as professor of comparative pathology at Washington University School of Medicine (WUSM).

Expressed sequence tag mapping of TMEM229B gene expression indicates that it is ubiquitously expressed throughout the body. TMEM229B is more heavily expressed in the parathyroid, skin, and thyroid tissues, and moderately expressed in bone marrow, trachea, spleen, eye, brain, pancreas, mammary gland, intestine, liver, thymus, lymph node, ovarian, muscle, lung, blood, and kidney tissues.

Russell speculated that it would have required a navel, as a placenta aids the development of a large brain case. However, it would not have possessed mammary glands and would have fed its young, as birds do, on regurgitated food. He speculated that its language would have sounded somewhat like bird song.Naish, D. (2006).

Expression of KIAA1107 does not appear to be ubiquitous in Homo sapiens. KIAA1107 is found to be expressed mostly in the brain, with lower levels of expression occurring in the bladder, mammary gland, muscle, prostate, and testis. Within the brain, KIAA1107 is expressed highest in the pineal gland, prefrontal cortex, cingulate cortex, and subthalamic nucleus.

When the cheek pouches become full, they extend back to the shoulder blades, which restrict movement. Campbell's dwarf hamster is prone to genetic abnormalities in the metabolism of carbohydrates and lipids. They can develop tumours of the mammary glands, lungs, uterus, and ovaries. Tumours can also develop if the animal is exposed to chemical carcinogens.

The pituitary gland grows by about one-third as a result of hyperplasia of the lactrotrophs in response to the high plasma estrogen. Prolactin, which is produced by the lactrotrophs increases progressively throughout pregnancy. Prolactin mediates a change in the structure of the breast mammary glands from ductal to lobular-alveolar and stimulates milk production.

It has been associated with TBX3. This gene is located on the long arm of chromosome 12 (12q24.21). Another gene that has been associated with this condition is SYNM.Zlotina A, Kiselev A, Sergushichev A, Parmon E, Kostareva A (2018) Rare case of ulnar-mammary-like syndrome With left ventricular tachycardia and lack of TBX3 mutation.

Russell speculated that it would have required a navel, as a placenta aids the development of a large brain case. However, it would not have possessed mammary glands, and would have fed its young, as some birds do, on regurgitated food. He speculated that its language would have sounded somewhat like bird song.Naish, D. (2006).

Elizabeth Macfarlane Sloan was born in Glasgow, the daughter of Elizabeth Macfarlane and Samuel Sloan. Her father was a physician. She attended Queen Margaret College, Glasgow, where she was awarded an MB and ChB in 1901. In 1919 she obtained her medical degree from Glasgow with a thesis titled "Breast-Feeding: Faradisation of the Mammary Glands".

Grolleau, I.Garrido; Mammary implant selection or chest implants fabrication with computer help; Ann.de chirurgie plastique esthétique (2010) 55,471-480. The implants are made of medical silicon rubber which is age- resistant and unbreakable (different to the silicon gel used in breast implants). They will last for life (apart from the case of adverse reactions) and are not visible externally.

The mice undergoing the process of transgenesis are known as transgenic mice. A basic transgene has a promoter region, Protein coding sequence, Intron and a stop codon. Mouse mammary tumor virus (MMTV), is a retro virus that has been a known promoter to cause breast tumors once activated. MMTV is a heritable somatic mutagen whose target range is limited.

TET1 binds (is recruited to) the OGG1 bound to 8-OHdG (see figure). This likely allows TET1 to demethylate an adjacent methylated cytosine. When human mammary epithelial cells (MCF-10A) were treated with H2O2, 8-OHdG increased in DNA by 3.5-fold and this caused about 80% demethylation of the 5-methylcytosines in the MCF-10A genome.

Leptin is an adipocyte hormone that has important implications of puberty and sex hormone secretion. Increased leptin has been linked to estrogen and estradiol secretion. Leptin has key roles in maintaining age appropriate body composition and desired weight. Leptin receptors are also found in mammary epithelial cells and leptin has been observed as a growth factor in breast tissue.

In addition, the mammary glands have more autonomy allowing them to supply separate milks to young at different development stages. Lactose is the main sugar in placental mammal milk while monotreme and marsupial milk is dominated by oligosaccharides. Weaning is the process in which a mammal becomes less dependent on their mother's milk and more on solid food.

In particular if the patient wishes to preserve breastfeeding ability, the condition of the mammary duct system is investigated by means of galactography (ductography) or ductoscopy in order to determine whether the excision of a single duct (microdochectomy) would be sufficient. Pre-operatively, also breast ultrasound and mammogram are performed to rule out other abnormalities of the breast.

The breast cancer susceptibility protein BRCA2 and PALB2 controls the function of Rad51 in the pathway for DNA repair by homologous recombination. In addition to the data listed in Table 1, increased RAD51 expression levels have been identified in metastatic canine mammary carcinoma, indicating that genomic instability plays an important role in the carcinogenesis of this tumor type.

Irish Independent. 3 March 2009. bisningsPeter Bird, Northamptonshire ACRE 'Village Voices' oral history recordings, Northamptonshire ACRE and Northamptonshire County Archives or first milk) is the first form of milk produced by the mammary glands of mammals (including humans) immediately following delivery of the newborn. Most species will begin to generate colostrum just prior to giving birth.

Hernandez grew up in El Paso, Texas. Initially she studied at Iowa State University, however she transferred to New Mexico State University where she completed her masters in animal science and toxicology. She started her PhD in 2005 at the University of Arizona with mammary gland physiologist Bob Collier. Hernandez joined the University of Wisconsin–Madison in 2011.

TRIM62, also called DEAR1 (for ductal epithelium–associated RING chromosome 1), is a protein in the tripartite motif family. In human it is encoded by the gene TRIM62. TRIM62 is involved in the morphogenesis of the mammary gland, and loss of TRIM62 gene expression in breast is associated with a higher risk of recurrence in early-onset breast cancer.

In human anatomy, the internal thoracic artery (ITA), previously known as the internal mammary artery (a name still common among surgeons), is an artery that supplies the anterior chest wall and the breasts. It is a paired artery, with one running along each side of the sternum, to continue after its bifurcation as the superior epigastric and musculophrenic arteries.

N-acetyllactosamine synthase falls under the category of beta-1,4-galactosyltransferase, a type-II membrane protein found in the Golgi. Alpha-lactalbumin is a Ca2+ binding protein specific to mammary glands. Beta-1,4-galactosyltransferase consists of the catalytic component and alpha- lactalbumin consists of the regulatory component of lactose synthase. Alpha- lactalbumin promotes glucose binding to beta-1,4-galactosyltransferase.

Pseudoephedrine may also suppress lactation, as it is known to cause low supply. In the US. Spitz et al. in a 100-year review of all available information concluded that there was nothing new or helpful to assist with the mammary involution or milk suppression process or to treat the pain or discomfort of severely engorged breasts.

These two ER types are encoded by different genes located on separate chromosomes and have different functions. ERα is mostly active in the mammary gland and uterus, and aide in the regulation of skeletal homeostasis and metabolism. ER-β on the other hand, plays a more prominent role in the central nervous and immune systems functional mechanisms.

She was promoted to Associate Professor in 2012 and full Professor in 2016. Her research considers how cells within tissues integrate complicated biological systems spatially and dynamically. At Princeton Nelson leads the Tissue Morphodynamic Laboratory, which combines engineering, cell biology and developmental biology. She investigates the morphogenesis process that builds both the mammary gland and vertebrate lung.

This causes the cells at the edge of the yolk to be cytoplasmically continuous with the egg's cytoplasm. This allows the yolk, which contains the embryo, to exchange waste and nutrients with the cytoplasm. The newly hatched young are vulnerable, blind, and hairless, and are fed by the mother's milk. Although possessing mammary glands, the platypus lacks teats.

Microcalcifications are tiny deposits of calcium salts that are too small to be felt but can be detected by imaging. They can be scattered throughout the mammary gland, or occur in clusters. Microcalcifications can be an early sign of breast cancer. Based on morphology, it is possible to classify by radiography how likely microcalcifications are to indicate cancer.

Gums contain galactose in form of galacturonic acid. This sugar is part of lactose, which is milk sugar, so consumption of gums in early mammals or their precursors might be a cause for development of mammary glands in mammals along with maternal instincts to feed their offspring and increased body lipids in females of early mammals.

Debnath, J, KR Mills, NL Collins, MJ Reginato, SK Muthuswamy, JS Brugge. "The role of apoptosis in creating and maintaining luminal space within normal and oncogene-expressing mammary acini." Cell 111.1 (2002): 29-40.Muranen, Taru, Laura M. Selfors, Devin T. Worster, Marcin P. Iwanicki, Loling Song, Fabiana C. Morales, Sizhen Gao, Gordon B. Mills, and Joan S. Brugge.

Pinc (pregnancy induced noncoding RNA) is a long non-coding RNA. It was originally identified in the mammary glands of oestrogen and progesterone- treated rats. Pinc may be a mammal-specific gene. It is conserved in a number of mammalian genomes (human, mouse, rat, chimpanzee, dog, cow and opossum), but not in fugu, zebrafish or xenopus genomes.

Nude mice have a spontaneous deletion in the FOXN1 gene. (Humans with mutations in FOXN1 also are athymic and immune deficient.) Mice with a targeted deletion in the FOXN1 ("knockout" mice) also show the "nude" phenotype. Since nude females have underdeveloped mammary glands and are unable to effectively nurse their young, nude males are bred with heterozygous females.

The female will develop mammary glands, lactate, and build nests in the pseudopregnant state. Pseudopregnancy in mice is somewhat common in laboratory mice because it is often induced for the purpose of implanting embryos into a surrogate dam, but is uncommon in wild mice because most wild males are fertile and will genuinely impregnate the female.

Normal breast tissue does not express H19 RNA, except during puberty and pregnancy in the mammary glands. However, in breast cancer, 72.5% of the breast adenocarcinomas studied by Adriaenssens et al. displayed increased H19 expression when compared to normal breast tissue. Of the tissues with upregulated H19, 92.2% are stromal cells and only 2.9% are epithelial cells.

This is the intrapulmonary variant. In contrast, later development of the accessory lung bud results in the extrapulmonary type that may give rise to communication with the GI tract. Both types of sequestration usually have arterial supply from the thoracic or abdominal aorta. Rarely, the celiac axis, internal mammary, subclavian, or renal artery may be involved.

There is a hypothesis that ID4 acts as a tumour suppressor factory in human breast tissue where oestrogen is responsible for regulation of ID4 expression in the mammary ductal epithelium. It is unclear whether the ID4 gene plays a role in bladder cancer. ID4 is found on the 6p22.3 amplicon which is frequently associated with advance stage bladder cancer.

Lymph vessels originating at the base of the nipples can ventrally extend as far as the intermammary cleftCharles Wesley Turner, The mammary gland (vol. 1), page 80, Lucas Bros., 1952 and to the opposite breast. The intermammary lymphatics begin as a bunch of small channels consisting of a single layer of epithelium that is supported by stroma tissues.

They give the breast its offspring-feeding functions as a mammary gland. They are distributed throughout the body of the breast. Approximately two-thirds of the lactiferous tissue is within 30 mm of the base of the nipple. The terminal lactiferous ducts drain the milk from TDLUs into 4–18 lactiferous ducts, which drain to the nipple.

Side effects of osaterone acetate include diminished sperm quality (for up to 6 weeks post-treatment), transient elevation of liver enzymes (caution should be observed with known liver disease), vomiting, diarrhea, polyuria/polydipsia, lethargy, and hyperplasia of the mammary glands. It can also decrease cortisol levels, interfere with adrenocorticotropic hormone response, induce or exacerbate adrenal insufficiency, and exacerbate diabetes mellitus.

Targeted expression of oncogenes in mouse mammary epithelial cells is a way of modeling human breast cancer. Mutation or over expression of oncogenes can be kept under controlled expression in a very specific cellular context rather than throughout the organism. Another way to model human breast cancer is done through the targeted inhibition of a tumor suppressor gene.Gupta, PB; Kuperwasser, C. (2004).

The RMF/EG fibroblast must then be irradiated to allow the expression of key proteins and growth factors. After 4 weeks of development, the newly en-grafted human mammary epithelial cells expanded within the fat pad.Kuperwasser, C; Chavarria, T; Wu, M; Magrane, G; Gray, JW; Carey, L; Richardson, A; Weinberg, RA. (2004). Reconstruction of functionally normal and malignant human breast tissue in mice.

They are the most malignant type of canine mammary tumor. Malignant tumors are also subdivided histopathologically into those showing blood vessel wall invasion and those that do not. Without blood vessel wall invasion there is a better prognosis. Dogs with noninvasive adenocarcinomas have an average survival time of two years, while dogs with invasive adenocarcinomas have an average survival time of one year.

Instead, they form temporary folds of skin - sometimes called a "pseudo-pouch" around the mammary glands during pregnancy. Young stay in this pseudo-pouch area, nursing for about 7 weeks before being moved to a nest where they stay until they are weaned at about 20 weeks of age. Females live for about 3 years, and generally produce one litter.

Some women use the pencil test to determine if their breasts are sagging. However, some degree of ptosis is normal and natural. Sagging is partly determined by inherited traits like skin elasticity and breast density, which affects the ratio of lightweight fat to heavier mammary glands. Some sagging is due to the aging of the glandular tissues that produce breast firmness.

Breast development, also known as mammogenesis, is a complex biological process in primates that takes place throughout a female's life. It occurs across several phases, including prenatal development, puberty, and pregnancy. At menopause, breast development ceases and the breasts atrophy. Breast development results in prominent and developed structures on the chest known as breasts in primates, which serve primarily as mammary glands.

Free floating intragastric balloons were used by Nieben and Harboe in 1982. Percival presented a “balloon diet” in 1984 when he placed inflated mammary implants as gastric balloons. In 1985 the Garren-Edwards Bubble was introduced as the first FDA-approved device, but the approval was withdrawn seven years later because of complications. Analysis of its problems led to recommendations for safer designs.

A similar but less severe immune disease is immune-mediated thrombocytopenia, characterized by destruction of platelets by the immune system. Clinical signs include bruising and petechiae (pinpoint bruising, often seen in the mouth). Common reproductive diseases include pyometra (distension of the uterus with pus), mammary tumors, and benign prostatic hyperplasia. Psychological anxieties affecting dogs include noise phobia and separation anxiety.

By influencing DNA damage repair, these three proteins play a role in maintaining the stability of the human genome. BRCA1 is also involved in another type of DNA repair, termed mismatch repair. BRCA1 interacts with the DNA mismatch repair protein MSH2. MSH2, MSH6, PARP and some other proteins involved in single-strand repair are reported to be elevated in BRCA1-deficient mammary tumors.

In 1922 Cheatle proposed that inflamed and cystic breasts should be removed surgically. He coauthored the textbook Tumours of the Breast (1931) with the American surgeon Max Cutter. This was called "the first modern textbook of mammary pathology". The textbook said that if there was only one "blue dome cyst" in a breast, removal of the cyst was usually sufficient.

The chemical compound Bisphenol A found in can linings "...is associated with organizational changes in the prostate, breast, testis, mammary glands, body size, brain structure and chemistry, and behavior of laboratory animals",Vogel, S. (2009). "The Politics of Plastics: The Making and Unmaking of Bisphenol A 'Safety'" . American Journal of Public Health 99 (S3): 559–566. unborn children and adults.

External abscesses are the most common form of pigeon fever seen in horses. Abscesses develop on the body, usually in the pectoral region and along the ventral midline of the abdomen. However, abscesses can also develop on other areas of the body such as the prepuce, mammary gland, triceps, limbs and head. The fatality rate for this form infection is very low.

Gunnison's prairie dogs are 12 to 14 inches (30 to 37 centimeters) in length and have tails that measure 1.25 to 2.25 inches (3 to 6 centimeters). This species weighs from 1.5 to 2.5 lbs (0.5 to 1 kg). On average, males are larger in size than females. Gunnison's prairie dogs have 22 teeth, and five pairs of mammary glands.

Adult females additionally have two teat-like projections on their abdomens, called pubic nipples or false nipples, which are not connected to mammary glands. Only a few other bat families have pubic nipples, including Hipposideridae, Craseonycteridae, Megadermatidae, and Rhinopomatidae; they serve as attachment points for their offspring. In a few horseshoe bat species, males have a false nipple in each armpit.

In 1999 Barbulescu, et al. showed that, of ten HERV-K proviruses cloned, eight were unique to humans, while one was shared with chimpanzees and bonobos, and one with chimpanzees, bonobos and gorillas. Originally, HERV-K was observed by low-stringency hybridization with probes for the mammary tumor virus of the mouse and A particle intracutaneous mouse. In 2015 Grow et al.

The Bittner virus is now known as the Mouse mammary tumor virus (MMTV), a retrovirus. (see Timeline of Discovery 1936 under Oncovirus). In 1947-48, Bittner was president of the American Association for Cancer Research and was a member of their board of directors from 1945 to 1951. He also served on the editorial advisory board of Cancer Research from 1941-1957.

Na+/I− symporter (NIS) – Sodium-Iodide is a type of symporter that is responsible for transferring iodide in the thyroid gland. NIS is primarily found in cells of the thyroid gland and also in the mammary glands. They are located on the basolateral membrane of thyroid follicular cells where 2 Na+ ions and 1 I− ion is coupled to transfer the iodide.

TET1 binds (is recruited to) the OGG1 bound to 8-OHdG (see figure). This likely allows TET1 to demethylate an adjacent methylated cytosine. When human mammary epithelial cells (MCF-10A) were treated with H2O2, 8-OHdG increased in DNA by 3.5-fold and this caused large scale demethylation of 5-methylcytosine to about 20% of its initial level in DNA.

Koala (Phascolarctos cinereus) Marsupials have the typical characteristics of mammals—e.g., mammary glands, three middle ear bones, and true hair. There are, however, striking differences as well as a number of anatomical features that separate them from Eutherians. In addition to the front pouch, which contains multiple teats for the sustenance of their young, marsupials have other common structural features.

A few species, such as the beluga whale, lack them. Both the flipper and the fin are for stabilization and steering in the water. The male genitals and mammary glands of females are sunken into the body. The body is wrapped in a thick layer of fat, known as blubber, used for thermal insulation and gives cetaceans their smooth, streamlined body shape.

At the apical membranes of the liver and kidney, it enhances excretion of xenobiotics. In the lactating mammary gland, it has a role on excreting vitamins such as riboflavin and biotin into milk. In the kidney and gastrointestinal tract, it has a role in urate excretion. The protein also carries the Jr(a) antigen, which defines the Junior blood group system.

This protein is known to be a factor that supports androgen and anchorage independent growth of mammary tumor cells. Overexpression of this gene has been shown to increase tumor growth and angiogenesis. The adult expression of this gene is restricted to testes and ovaries. Temporal and spatial pattern of this gene expression suggests its function as an embryonic epithelial factor.

The ZNF703 gene generally plays an active role in luminal B tumor cells contained in mammary ducts. Typically, ZNF703 expression is greater when the tumors are estrogen receptor positive as opposed to estrogen receptor negative. ZNF703 is co-expressed in a nuclear complex containing genes DCAF7, NCRO2 and PHB2. ZNF703 generates a nuclear protein responsible for oestrogen receptor associated protein repression.

The medication has weak glucocorticoid activity and no other important hormonal activity. CMA was discovered in 1959 and was introduced for medical use in 1965. It may be considered a "first-generation" progestin. The medication was withdrawn in some countries in 1970 due to concerns about mammary toxicity observed in dogs, but this turned out not to apply to humans.

The abdominal area is the region between the chest and the pelvis. The breast is called the mamma or mammary, the armpit as the axilla and axillary, and the navel as the umbilicus and umbilical. The pelvis is the lower torso, between the abdomen and the thighs. The groin, where the thigh joins the trunk, are the inguen and inguinal area.

Mammary system, developed and well set, with well-implanted teats of moderate size. The milk production often exceeds the intake capacity of calves during the first months of life but these run out in the following months until weaning. End and uprightness: short and slender members below the knee and hock; the right hind and forelegs knees deflected inward. Thigh convex.

Twist1 and Twist2, as well as ZEB1 protects human cells and mouse embryonic fibroblasts from senescence. Similarly, TGF-β can promote tumor invasion and evasion of immune surveillance at advanced stages. When TGF-β acts on activated Ras-expressing mammary epithelial cells, EMT is favored and apoptosis is inhibited. This effect can be reversed by inducers of epithelial differentiation, such as GATA-3.

Several preclinical trials were conducted in different model systems. In 2002, a study published by Vacca et al. showed that endothelial cells incubated with NAMI-A, were not able to proliferate but that NAMI-A didn't kill the cells that were already grown. One trial was done to test the efficacy of NAMI-A in female grafted with MCa mammary carcinoma cells.

Litters can range in size from two to six, with a typical litter size of three. The females have only four mammary glands, so larger litters most likely have higher attrition rates. Females have been observed breeding as soon as 12 hours after giving birth, and may be pregnant with one litter while nursing another. Gestation period in captivity is 27–32 days.

Similarly, levels of estradiol, estrone, and estrone sulfate are all strongly associated with the risk of breast cancer in women. Preclinical studies have shown that estrone sulfate, via local transformation into estradiol, stimulates the growth of mammary cancer cells. Due to the first pass through the liver, disproportionate and supraphysiological levels of estrogens occur locally in the liver with oral estradiol.

By the end of the fourth month of pregnancy, at which time lobuloalveolar maturation is complete, the breasts are fully prepared for lactation and breastfeeding. Insulin, glucocorticoids such as cortisol (and by extension adrenocorticotropic hormone (ACTH)), and thyroid hormones such as thyroxine (and by extension thyroid-stimulating hormone (TSH) and thyrotropin-releasing hormone (TRH)) also play permissive but less well-understood/poorly- characterized roles in breast development during both puberty and pregnancy, and are required for full functional development. Leptin has also been found to be an important factor in mammary gland development, and has been found to promote mammary epithelial cell proliferation. In contrast to the female- associated sex hormones, estrogen and progesterone, the male-associated sex hormones, the androgens, such as testosterone and dihydrotestosterone (DHT), powerfully suppress the action of estrogen in the breasts.

In the mammary epithelium and breast cancer cells, MTA3 is an estrogen regulated gene and part of a larger regulatory network involving MTA1 and MTAs, all modifiers of hormone response, and participate in the processes involved in growth and differentiation. Accordingly, the MTA3-NuRD complex regulates the expression of Wnt4 in mammary epithelial cells and mice, and controls Wnt4-dependent ductal morphogenesis. In contrast to its repressive actions, MTA3 also stimulates the expression of HIF1α as well as its target genes under hypoxic conditions in trophoblasts and is thought to be involved in differentiation during pregnancy. MTA3-NuRD complex and downstream targets have been shown to participate in primitive hematopoietic and angiogenesis in a zebrafish model system As a part of BCL6 corepressor complex, MTA3 regulates BCL6-dependent repression of target genes, including PRDM1, and modulates the differentiation of B-cells.

The fore feet have five long digits with broad, blunt tips and short, narrow claws that hardly project beyond the tips of the digits. The hind feet are short and broad and have five digits with blunt, calloused tips, the hallux (big toe) being shorter than the others and having a nail rather than a claw. The female has three pairs of mammary glands.

Overall, unspayed female dogs have a seven times greater risk of developing mammary neoplasia than do those that are spayed. While the benefit of spaying decreases with each estrous cycle, some benefit has been demonstrated in female dogs even up to 9 years of age. There is a much lower risk (about 1 percent) in male dogs and a risk in cats about half that of dogs.

Loss of p27 expression has been observed in metastatic canine mammary carcinomas. Decreased TGF-beta signalling has been suggested to cause loss of p27 expression in this tumor type. A structured cis-regulatory element has been found in the 5' UTR of the P27 mRNA where it is thought to regulate translation relative to cell cycle progression. P27 regulation is accomplished by two different mechanisms.

A galactocele (also called lacteal cyst or milk cyst) is a retention cyst containing milk or a milky substance that is usually located in the mammary glands. They can occur in women during or shortly after lactation. They present as a firm mass, often subareolar, and are caused by the obstruction of a lactiferous duct. Clinically, they appear similar to a cyst on examination.

Results support role in DNA synthesis linked to histone H4 acetylation. In cultured cells knock down of lncRNA-JADE increased cells sensitivity to DNA damaging drugs. In mice tumor xenograft model, the knock down of lncRNA-JADE inhibited xenograft mammary tumor growth. In a pilot human study, higher levels of lncRNA-JADE as well as JADE1 protein were detected in breast cancer tissues compared to normal tissues.

In an in vivo study, 8-PN has activated proliferation of mammary cells. At the concentration found in beer, it is unlikely to have an estrogenic effect in breast tissue. Similar to other estrogens, 8-PN induces the expression of the progesterone receptor in various tissues. Luteinizing hormone (LH) and follicle stimulating hormone (FSH) are suppressed by 8-PN, indicating that it possesses antigonadotropic properties.

Marbofloxacin can be used both orally and topically. It is particularly used for infections of the skin, respiratory system and mammary glands in dogs and cats, as well as with urinary tract infections. For dogs, a dose ranges from 2.75 - 5.5 mg/kg once a day. The duration of treatment is usually at least five days, longer if there is a concurrent fungal or yeast infection.

The discovery of Wnt signaling was influenced by research on oncogenic (cancer-causing) retroviruses. In 1982, Roel Nusse and Harold Varmus infected mice with mouse mammary tumor virus in order to mutate mouse genes to see which mutated genes could cause breast tumors. They identified a new mouse proto-oncogene that they named int1 (integration 1). Int1 is highly conserved across multiple species, including humans and Drosophila.

Working against estrogen, the presence of testosterone in a pubescent female inhibits breast development and promotes muscle and facial hair development. Estrogen levels also rise significantly during pregnancy. A number of other changes typically occur during pregnancy, including enlargement and increased firmness of the breasts, mainly due to hypertrophy of the mammary gland in response to the hormone prolactin. The size of the nipples may increase noticeably.

PMCA2 expression falls on weaning, leading to calcium-induced apoptosis and mammary gland involution. Persistent PMCA2 expression in certain breast cancers lowers calcium levels inside malignant cells, allowing them to avoid apoptosis. These tumors are also usually positive for the HER2 protein, tend to involve the lymph nodes, and are more common among young women, which could help explain their worse prognosis compared with postmenopausal women.

Breast engorgement occurs in the mammary glands due to expansion and pressure exerted by the synthesis and storage of breast milk. It is also a main factor in altering the ability of the infant to latch-on. Engorgement changes the shape and curvature of the nipple region by making the breast inflexible, flat, hard, and swollen. The nipples on an engorged breast are flat or inverted.

During both of these periods, progesterone levels are high. Because the hormonal profile of a pregnant female and a female in diestrus are the same, sometimes a non-pregnant female will go through a period of pseudo-pregnancy. At that time she may gain weight, have mammary gland development, produce milk, and exhibit nesting behaviours. 4\. Anestrus is the remaining period, the time of reproductive quiescence.

The number of mammary glands is variable and correlates, as in all mammals, with litter size. Pigs, which have the largest litter size of all even-toed ungulates, have two rows of teats lined from the armpit to the groin area. In most cases, however, even-toed ungulates have only one or two pairs of teats. In some species, these form an udder in the groin region.

OSMR is widely expressed across non-haematopoietic, hepatocytes, mesothelial cells, glial cells and epithelial cell types across various organs and mammary glands. OSM receptor is abundantly expressed on endothelial and stromal/fibroblast cells in the lung of mice.= In vitro expression of OSMR in fetal hepatocytes is upregulated by OSM stimulation. OSMR expression has been shown to be induced by parathyroid hormone in osteoblasts and OSM.

The equid mammary gland has a low capacity (max 2.5 l) and a part of the milk production should be left to the foal and milking may be carried out two or three hours after separation from the foal.Doreau M (1991) Le lait de jument. INRA Productions Animales 4 :297–302. Donkeys should be milked three times a day from 20 to 90 days after foaling.

Milk lipids are secreted in a unique manner by lactocytes, which are specialized epithelial cells within the alveoli of the lactating mammary gland. The process takes place in multiple stages. First, fat synthesized within the endoplasmic reticulum accumulates in droplets between the inner and outer phospholipid monolayers of the endoplasmic reticulum membrane. As these droplets increase in size, the two monolayers separate further and eventually pinch off.

A single intramuscular injection of 80 mg PE3P has a duration of about 1 month and of 80 mg about 2 months. The effects of PE3P on the vagina, uterus, pregnancy, prostate gland, coagulation, and fibrinolysis, as well as on mammary and endometrial cancer risk, have been studied. The endometrial proliferation dose of PE3P over 14 days in women is 40 to 60 mg by intramuscular injection.

Unlike humans, short-beaked common dolphins have no lips and cannot suck on the teats of its mother. If they did have this ability they would drown. Thus, the female dolphin's mammary glands have a muscle that when contracted, squirts milk so that it can feed its calf. Maximum lifespan is 35 years, but has been estimated at 22 years for the Black Sea population.

The teeth are shed once (milk teeth) during the animal's lifetime or not at all, as is the case in cetaceans. Mammals have three bones in the middle ear and a cochlea in the inner ear. They are clothed in hair and their skin contains glands which secrete sweat. Some of these glands are specialized as mammary glands, producing milk to feed the young.

4T1 resembles human metastatic triple-negative breast cancer (TNBC) in lack of the expression of estrogen receptor (ER), progesterone receptor (PR), and epidermal growth factor receptor 2 (HER2). In addition, it was described, that this cell line is poorly immunogenic in mice, which coresponds to the characteristics of human mammary adenocarcinoma and leads to the higher tumorigenicity and invasivness of this breast cancer model.

Image of peptide somatotropine. In 1937, the administration of BST was shown to increase the milk yield in lactating cows by preventing mammary cell death in dairy cattle. Until the 1980s, use of the compound was very limited in agriculture as the sole source of the hormone was from bovine carcasses. During this time, the knowledge of the structure and function of the hormone increased.

PELP1 is a proto-oncogene that provides cancer cells with a distinct growth and survival advantage. PELP1 interacts with various enzymes that modulate the cytoskeleton, cell migration, and metastasis. PELP1 deregulation in vivo promotes development of mammary gland hyperplasia and carcinoma PELP1 is implicated in progression of breast, endometrial, ovarian, salivary prostate, lung, pancreas, and colon neoplasms. PELP1 signaling contributes to hormonal therapy resistance.

Determining pregnancy status can be difficult due to the animal's large abdominal cavity. The female's mammary glands occupy the space between the front legs, which puts the suckling calf within reach of the female's trunk. Elephants have a unique organ, the temporal gland, located in both sides of the head. This organ is associated with sexual behaviour, and males secrete a fluid from it when in musth.

The innominate artery usually gives off no branches, but occasionally a small branch, the thyreoidea ima, arises from it. Other times, it gives off a thymic or bronchial branch. It varies greatly in size, and appears to compensate for deficiency or absence of one of the other thyroid vessels. It occasionally arises from the aorta, the right common carotid, the subclavian or the internal mammary.

Mammary gland tumors are the third common type of cancer in older female cats, with the most common symptom manifesting as a lump in the breast tissue. Domestic short-haired cats and Siamese appear to have a higher incident rates. The tumor is typically firm and nodular, and adheres to the overlying skin. Nipples may also appear to be red and swollen, oozing yellowish fluid.

Phenothrin has been found to possess antiandrogen properties, and was responsible for a small epidemic of gynecomastia via isolated environmental exposure. The EPA has not assessed its effect on cancer in humans. However, one study performed by the Mount Sinai School of Medicine linked sumithrin with breast cancer; the link made by its effect on increasing the expression of a gene responsible for mammary tissue proliferation.

Immediately after birth, H19 expression is downregulated in all tissues except for skeletal muscle. Studies by Tanos et al. suggest that the accumulation of H19 RNA in skeletal muscle cells is solely due to the stabilization of that RNA in the muscle cells during differentiation. In females, H19 is expressed postnatally during puberty and pregnancy in the mammary glands, and in the uterus during pregnancy.

The book also contains descriptions of a typical mammary fistula; treatment of the same by seton stitch; breast cysts; and mastalgia and galactorrhea. Mansel, Sweetland, and Hughes describe the macroscopic and microscopic illustrations of duct ectasia and fibroadenoma in the plates as "ahead of their time", also observing that the descriptions of duct ectasia pre-date the work of Joseph Colt Bloodgood by half a century.

Aromatic amines are chemicals that are produced when products such as dyes, polyurethane products, and certain pesticides are made. They are also found in cigarette smoke, fuel exhaust, and in over cooked, burned meat. The three types of aromatic amines monocyclic, polycyclic, and heterocyclic have all been found in recent studies of breast health. Monocyclic amines have been found to cause mammary cancer in rats.

OCLC no. 19432229. This means that the sale of numerous acts such as oral sex, anal sex, mammary intercourse and other non-coital sex acts is legal. The , also known as the "Law to Regulate Adult Entertainment Businesses", amended in 1985, 1999 and 2005, regulates these businesses. Since sexual intercourse for money is officially prohibited, the sex industry in Japan has developed into a variety of forms.

Latest Mammary Ductoscope, also called Micro Endoscope, is available with the diameter of 0.35 mm. The endoscopes is used along with a 3-way cannula. The other two ports are used for saline irrigation and Biopsy Forceps of 0.4 mm diameter. Ductoscopy can also be performed in conjunction with a lumpectomy, allowing the surgeon to achieve clean margins with a minimum of excess tissue removed.

CMA is not available in English-speaking countries including the United States, Canada, the United Kingdom, Ireland, South Africa, Australia, or New Zealand, nor is it marketed in any of the Nordic countries. CMA was previously marketed in the United States and the United Kingdom in the 1960s, but it was withdrawn in these countries in 1970 due to intermittent concerns about mammary toxicity in dogs.

Apolipoprotein D is a protein that in humans is encoded by the APOD gene. Unlike other lipoproteins, which are mainly produced in the liver, apolipoprotein D is mainly produced in the brain and testes. It is a 29 kDa glycoprotein discovered in 1963 as a component of the High Density Lipoprotein (HDL) fraction of human plasma. It is the major component of human mammary cyst fluid.

If the narrowings in coronary arteries are unsuitable for treatment with a percutaneous coronary intervention, open surgery may be required. A coronary artery bypass graft can be performed, whereby a blood vessel from another part of the body (the saphenous vein, radial artery, or internal mammary artery) is used to redirect blood from a point before the narrowing (typically the aorta) to a point beyond the obstruction.

The term nonpuerperal mastitis describes inflammatory lesions of the breast occurring unrelated to pregnancy and breastfeeding. This article includes description of mastitis as well as various kinds of mammary abscesses. Skin related conditions like dermatitis and foliculitis are a separate entity. Names for non-puerperal mastitis are not used very consistently and include mastitis, subareolar abscess, duct ectasia, periductal inflammation, Zuska's disease and others.

Accordingly, ERα, amphiregulin, and EGFR knockout mice copy each other phenotypically in regards to their effects on ductal development. Also in accordance, treatment of mice with amphiregulin or other EGFR ligands like TGF-α or heregulin induces ductal and lobuloalveolar development in the mouse mammary gland, actions that occur even in the absence of estrogen and progesterone. As both the IGF-1R and the EGFR are independently essential for mammary gland development, and as combined application of IGF-1 and EGF, through their respective receptors, has been found to synergistically stimulate the growth of human breast epithelial cells, these growth factor systems appear to work together in mediating breast development. Elevated levels of HGF and, to a lesser extent, IGF-1 (by 5.4-fold and 1.8-fold, respectively), in breast stromal tissue, have been found in macromastia, a very rare condition of extremely and excessively large breast size.

In animals, fatty acids are formed from carbohydrates predominantly in the liver, adipose tissue, and the mammary glands during lactation. Carbohydrates are converted into pyruvate by glycolysis as the first important step in the conversion of carbohydrates into fatty acids. Pyruvate is then decarboxylated to form acetyl-CoA in the mitochondrion. However, this acetyl CoA needs to be transported into cytosol where the synthesis of fatty acids occurs.

In chapter 10, Ariely started out with a medical procedure called internal mammary artery ligation for chest pain. The interesting twist is when a cardiologist decided to test the efficacy of this procedure by performing a placebo procedure. The result showed that the placebo is equally effective, thereby disputing the effectiveness of the original surgery. This example is one of many that illustrate the power of placebo in medical science.

Hand milking Reindeer milking (19th century) Milking is the act of removing milk from the mammary glands of cattle, water buffalo, humans, goats, sheep and more rarely camels, horses and donkeys. Milking may be done by hand or by machine, and requires the animal to be currently or recently pregnant. The milker may refer either to the animal that produces the milk or the person who milks said animal.

Larger posterior or lower cheek defects up to 10 cm can be closed if the incision of an anterior-based cervicofacial flap is extended, converting it into a cervicopectoral flap, which moves neck and chest skin to the face. This flap is vascularized by the internal mammary perforators. Advantages of this flap are its good skin color, texture, hair-bearing match and the location of the scars at natural folds.

Initial management in hospital is by pericardiocentesis. This involves the insertion of a needle through the skin and into the pericardium and aspirating fluid under ultrasound guidance preferably. This can be done laterally through the intercostal spaces, usually the fifth, or as a subxiphoid approach. A left parasternal approach begins 3 to 5 cm left of the sternum to avoid the left internal mammary artery, in the 5th intercostal space.

Gestation ends with childbirth, delivery following labor. Labor consists of the muscles of the uterus contracting, the cervix dilating, and the baby passing out the vagina (the female genital organ). Human's babies and children are nearly helpless and require high levels of parental care for many years. One important type of parental care is the use of the mammary glands in the female breasts to nurse the baby.

Interference with research may involve: : [Inhibition of] tumor induction due to polyoma virus, and mammary tumor virus in the mouse, and [interference] with transplantable leukaemia in the guinea pig and the mouse. Infection is associated with depression of cellular immunity in the mouse. Rejection of cutaneous grafts or transplantable tumors may be delayed. In addition, infection will increase the sensitivity of the mouse to ectromelia virus and to bacterial endotoxins.

The efferent vessels of the tracheobronchial lymph nodes ascend upon the trachea and unite with efferents of the internal mammary and anterior mediastinal glands to form the right and left bronchomediastinal trunks. The right bronchomediastinal trunk may join the right lymphatic duct, and the left the thoracic duct, but more frequently they open independently of these ducts into the junction of the internal jugular and subclavian veins of their own side.

Nitrofurazone is suspected to be a human carcinogen and is included in California's list of toxic chemicals as defined by Proposition 65. Studies demonstrate that nitrofurazone induces mammary tumors (fibroadenoma and adenocarcinoma) in rats and ovarian tumors in mice. In addition, animal studies demonstrated an increased incidence in convulsive seizures, ovarian atrophy, testicular degeneration, and degeneration of articular cartilage. Proper personal protective equipment should be utilized when handling nitrofurazone.

However, certain medical problems are more likely after neutering, such as urinary incontinence in females and prostate cancer in males. Dogs shown in the conformation ring are not allowed to be either neutered or spayed. It disqualifies them from being shown as they must be intact and unaltered. Female cats and dogs are seven times more likely to develop mammary tumors if they are not spayed before their first heat cycle.

Amazia refers to a condition where one or both of the mammary glands is absent (the nipple and areola remain present). This may occur either congenitally or iatrogenically (typically the result of surgical removal and/or radiation therapy). Amazia can be treated with breast implants. Amazia differs from amastia (the complete absence of breast tissue, nipple, and areola), although the two conditions are often (erroneously) thought to be identical.

In humans, milk lines form as thickenings of the epidermis of the mammary ridge, along the front surface of both sexes of mammals. Milk lines appear in the seventh week of embryonic development before human sexual differentiation, which explains why male humans have nipples. After initial development of the milk lines they go into remission. Most humans have two nipples, but in some cases more than two will develop.

Masturbation cream or masturbation creme is a personal lubricant designed to optimize sensation during the act of male masturbation. It can also be used in mammary intercourse, by applying it to the woman's breasts. Masturbation creams often contain oil-based ingredients, which are not compatible with latex condoms. Brands on the market include Senzuri, Stroke 29, Swiss Navy Masturbation Cream, and Hardware Wank Wax Heavy Duty Masturbation Wax.

The back as a general area is the dorsum or dorsal area, and the lower back is the lumbus or lumbar region. The shoulder blades are the scapular area and the breastbone is the sternal region. The abdominal area is the region between the chest and the pelvis. The breast is also called the mammary region, the armpit as the axilla and axillary, and the navel as the umbilicus and umbilical.

It was taken by mouth. The main components of conjugated estriol are estriol glucuronides and to a lesser extent estriol sulfates. Estrogen glucuronides can be deglucuronidated into the corresponding free estrogens by β-glucuronidase in tissues that express this enzyme, such as the mammary gland, liver, and kidney, among others. Likewise, estrogen sulfates can be desulfated into the corresponding free estrogens by steroid sulfatase in tissues that express this enzyme.

4T1 cell culture - 50% confluence 4T1 is a breast cancer cell line derived from the mammary gland tissue of a mouse BALB/c strain. 4T1 cells are epithelial and are resistant to 6-thioguanine. In preclinical research, 4T1 cells have been used to study breast cancer metastasis as they can metastasize to the lung, liver, lymph nodes, brain and bone. The cells are known to be highly aggressive in live tissues.

Placental lactogen I and II were identified as prolactin-like molecules that can bind to prolactin receptor with high affinity and mimic the actions of prolactin. These hormones can contribute to lactogenesis, luteal maintenance and progesterone production (in rats) during the later stages of gestation. Placental lactogen I may be important in stimulating mammary cell proliferation and in stimulating some of the adaptations of the maternal lipid and carbohydrate metabolism.

Fancy rats of both sexes commonly develop mammary tumors as they age. These are usually benign, but multiple tumors can persist even after removal. Human-raised R. norvegicus are more prone to specific health risks and diseases than their wild counterparts, but they are also far less likely to succumb to certain illnesses that are prevalent in the wild. The major considerations for susceptibility include exposure, living conditions, and diet.

Betaretrovirus is a genus of the Retroviridae family. It has type B or type D morphology. The type B is common for a few exogenous, vertically transmitted and endogenous viruses of mice; some primate and sheep viruses are the type D. Examples are Mouse mammary tumor virus, enzootic nasal tumor virus (ENTV-1, ENTV-2), and simian retrovirus types 1, 2 and 3 (SRV-1, SRV-2, SRV-3).

The dithiolethiones are a class of organosulfur compounds, of which oltipraz, an NRF2 inducer, is the best studied. Oltipraz inhibits cancer formation in rodent organs, including the bladder, blood, colon, kidney, liver, lung, pancreas, stomach, and trachea, skin, and mammary tissue. However, clinical trials of oltipraz have not demonstrated efficacy and have shown significant side effects, including neurotoxicity and gastrointestinal toxicity. Oltipraz also generates superoxide radical, which can be toxic.

GATA3 is one of the three genes mutated in >10% of breast cancers (Cancer Genome Atlas). Studies in mice indicate that the gene is critical for the normal development of breast tissue and directly regulates luminal cell (i.e. cells lining mammary ducts) differentiation in experimentally induced breast cancer. Analytic studies of human breast cancer tissues suggest that GATA3 is required for specific type of low risk breast cancer (i.e.

Moreover, since EpCAM and other proteins (e.g. cytokeratins) are not expressed in some tumors and can be down regulated during the epithelial to mesenchymal transition (EMT), new enrichment strategies are required. First evidence indicates that CTC markers applied in human medicine are conserved in other species. Five of the more common markers including CK19 are also useful to detect CTC in the blood of dogs with malignant mammary tumors.

Raloxifene has antiestrogenic effects in the mammary glands in preclinical studies. In accordance, raloxifene reduces breast density in postmenopausal women, a known risk factor for breast cancer. It does not stimulate the uterus in postmenopausal women, and results in no increase in risk of endometrial thickening, vaginal bleeding, endometrial hyperplasia, or endometrial cancer. At the same time, raloxifene has minimal antiestrogenic effect in the uterus in premenopausal women.

T-box transcription factor TBX5 is a protein that in humans is encoded by the TBX5 gene. This gene is a member of a phylogenetically conserved family of genes that share a common DNA-binding domain, the T-box. T-box genes encode transcription factors involved in the regulation of developmental processes. This gene is closely linked to related family member T-box 3 (ulnar mammary syndrome) on human chromosome 12.

While adult males are slightly larger and more muscular than females, with wider heads and necks, visual sex determination can be difficult. The penis and testes are located internally between the rectum and urinary bladder in males, and females have a single pair of mammary glands near the armpits. The giant anteater has broad ribs. Despite its specific name, tridactyla, meaning three fingers, it has five toes on each foot.

Expression of C9orf152 in the brain of a mouse via Allen Brain Atlas. The only area of high expression is the dark purple on the left, which is located in the olfactory bulb. C9orf152 is expressed in the bladder, intestine, mammary gland, and trachea and in smaller amounts in the lungs, liver, prostate, uterus, and brain. Within the brain, expression of C9orf152 is limited to the olfactory bulb.

Progesterone causes the milk sacs (mammary alveoli) to develop, and with the right stimuli, a transgender woman may lactate. Additionally, HRT often makes the nipples more sensitive to stimulation. Breast development in transgender women begins within 2 to 3 months of the start of hormone therapy and continues for up to 2 years. Breast development seems to be better in transgender women who have a higher body mass index.

DNMT1 plays a critical role in Hematopoietic stem cell (HSC) maintenance. HSCs with reduced DNMT1 fail to self-renew efficiently post-transplantation. It has also been shown to be critical for other stem cell types such as Intestinal stem cells (ISCs) and Mammary stem cells (MaSCs). Conditional deletion of DNMT1 results in overall intestinal hypomethylation, crypt expansion and altered differentiation timing of ISCs, and proliferation and maintenance of MaSCs.

The prototypic oncoantigen is HER2/neu, a membrane tyrosine kinase similar to the epidermal growth factor receptor (EGFR, or HER-1), expressed in about one-fourth of breast cancers. Vaccines against HER2/neu were shown to prevent mammary carcinoma in HER2/neu transgenic mice and are being tested for cancer therapy in humans. Monoclonal antibodies against HER-2 (e.g. trastuzumab) are approved for therapy of human breast cancer.

The breast is one of two prominences located on the upper ventral region of the torso of primates. In females, it serves as the mammary gland, which produces and secretes milk to feed infants. Both females and males develop breasts from the same embryological tissues. At puberty, estrogens, in conjunction with growth hormone, cause breast development in female humans and to a much lesser extent in other primates.

The primary function of the breasts, as mammary glands, is the nourishing of an infant with breast milk. Milk is produced in milk- secreting cells in the alveoli. When the breasts are stimulated by the suckling of her baby, the mother's brain secretes oxytocin. High levels of oxytocin trigger the contraction of muscle cells surrounding the alveoli, causing milk to flow along the ducts that connect the alveoli to the nipple.

The FGF3 gene was identified by its similarity with mouse fgf3/int-2, a proto-oncogene activated in virally induced mammary tumors in the mouse. Frequent amplification of this gene has been found in human tumors, which may be important for neoplastic transformation and tumor progression. Studies of the similar genes in mouse and chicken suggested the role in inner ear formation. Also, haploinsufficiency in the FGF3 gene is thought to cause otodental syndrome.

The MMTV-LTR can also be used to promote receptor tyrosine-protein kinase ErbB2 to transform the mouse mammary epithelium. ErbB2 is an oncogene amplified and overexpressed in around 20% of human breast cancers. The mice harbouring this oncogene develop multifocal adenocarcinomas with lung metastases at about 15 weeks after pregnancy. To create a more accurate representation of HER2 gene mutations, researchers have fused the mouse gene containing neu and a rat gene containing neu.

Foxes tend to have an average litter size of four to five with an 80 percent success rate in becoming pregnant. Litter sizes can vary greatly according to species and environmentthe Arctic fox, for example, can have up to eleven kits. The vixen usually has six or eight mammae. Each teat has 8 to 20 lactiferous ducts, which connect the mammary gland to the nipple, allowing for milk to be carried to the nipple.

In realizing the breast lift, the mastopexic correction takes anatomic and histologic account of the biomechanical, load-bearing properties of the three (3) tissue types (glandular, adipose, skin) that compose and support the breast; among the properties of the soft tissues of the breast is near-incompressibility (Poisson's ratio of ∼0.5). # Rib cage. The 2nd, 3rd, 4th, 5th, and 6th ribs of the thoracic cage are the structural supports for the mammary glands. # Chest muscles.

Dogs spayed before their first heat have 0.5 percent of this risk, and dogs spayed after just one heat cycle have 8 percent of this risk. The tumors are often multiple. The average age of dogs with mammary tumors is ten to eleven years old. Obesity at one year of age and eating red meat have also been associated with an increased risk for these tumors, as has the feeding of high fat homemade diets.

Involvement of the lymph nodes does not directly cause any harm, but is merely an indicator of systemic spread. Furthermore, patients with an identifiable associated underlying breast tumor have a survival rate of 38-40% at five years and a survival rate of 22-33% at 10 years. The death rate of metastatic breast carcinoma in patients with mammary Paget's disease and underlying cancer is 61.3%, with a 10-year cumulative survival rate of 33%.

Progesterone plays an important role in breast development in women. In conjunction with prolactin, it mediates lobuloalveolar maturation of the mammary glands during pregnancy to allow for milk production and thus lactation and breastfeeding of offspring following parturition (childbirth). Estrogen induces expression of the PR in breast tissue and hence progesterone is dependent on estrogen to mediate lobuloalveolar development. It has been found that is a critical downstream mediator of progesterone-induced lobuloalveolar maturation.

In 1986 he was among the scientists who launched the Human Genome Project. From 1993 to 1997 he moved back to Italy, where he was president of the Institute of Biomedical Technologies at C.N.R. (National Council of Research) in Milan. He also retained his position on the faculty of Salk Institute for Biological Studies. Dulbecco was actively involved in research into identification and characterization of mammary gland cancer stem cells until December 2011.

FABPs are divided into at least three distinct types, namely the hepatic-, intestinal- and cardiac-type. They form 14-15 kDa proteins and are thought to participate in the uptake, intracellular metabolism and/or transport of long-chain fatty acids. They may also be responsible in the modulation of cell growth and proliferation. Fatty acid-binding protein 3 gene contains four exons and its function is to arrest growth of mammary epithelial cells.

In addition, if the survival of the rats is less than 50% at 104 weeks (which is likely for Sprague-Dawley rats) the recommended number of rats is 65. The Séralini study had only ten per group. Tom Sanders from King's College London noted a lack of data on amount of food given, and on growth rates. Further noting that rats are susceptible to mammary tumors when food intake is not restricted.

Seralini also originally claimed males in groups fed 22% and 33% genetically modified maize had three times lower mortality than controls, but this was also not statistically significant. The findings of liver necrosis and mammary tumors were also not significant. A 2017 study found that since it was retracted, Seralini et al. (2012) had been cited 60 times after it was retracted, and that more of these citations were negative (39%) than were positive (26%).

Surgical bypass grafting and percutaneous coronary artery revascularization are traditionally considered isolated options. A simultaneous hybrid approach may allow an opportunity to match the best strategy for a particular anatomic lesion. Thus hybrid coronary revascularization and MIDCAB (minimally invasive direct coronary artery bypass surgery) have been developed. Revascularization of the left anterior descending artery with the left internal mammary artery is by far the best treatment option in terms of long-term results.

This means sale of numerous acts such as oral sex, anal sex, mammary intercourse and other non-coital sex acts are legal. Paid sex between "specified persons" (acquaintances) is not prohibited. Soaplands exploit this by providing a massage, during which the prostitute and client become "acquainted", as a preliminary to sexual services. The , also known as the "Law to Regulate Adult Entertainment Businesses", amended in 1985, 1999 and 2005, regulates these businesses.

Cathepsin L2, also known as cathepsin V and encoded by the CTSV gene, is a human gene. The protein encoded by this gene, a member of the peptidase C1 family, is a lysosomal cysteine proteinase that may play an important role in corneal physiology. This gene is expressed in colorectal and breast carcinomas but not in normal colon, mammary gland, or peritumoral tissues, suggesting a possible role for this gene in tumor processes.

Metastasis-associated protein MTA3 is a protein that in humans is encoded by the MTA3 gene. MTA3 protein localizes in the nucleus as well as in other cellular compartments MTA3 is a component of the nucleosome remodeling and deacetylate (NuRD) complex and participates in gene expression. The expression pattern of MTA3 is opposite to that of MTA1 and MTA2 during mammary gland tumorigenesis. However, MTA3 is also overexpressed in a variety of human cancers.

In zoology, male lactation is production of milk (lactation) from a male mammal's mammary glands. It is well-documented in the Dayak fruit bat and the Bismarck masked flying fox. The term male lactation is not used in human medicine. It has been used in popular literature, such as Louise Erdrich's The Antelope Wife, to describe the phenomenon of male galactorrhea, which is a well-documented condition in humans, unrelated to childbirth or nursing.

Ansfield was born on August 30, 1910, in Milwaukee, Wisconsin. By age 13, both of his parents had died from cancer, steering him towards medicine and cancer research. He attended the University of Wisconsin, receiving his Bachelor's degree in 1931. During this period he first had the idea to use mice to find a cure for mammary cancer in animals. Ansfield received his M.D. in 1933 from the University of Wisconsin Medical School.

Although Jacobsohn was not permitted to do research as she was a foreigner without a Swedish degree, she worked with Westman at Lund University and ran clinical hormone assays for the hospital. Nonetheless, she published over 22 research papers during this 10 year collaboration. In 1944, she gained Swedish citizenship and in 1948, a Swedish medical degree, with a thesis on mammary gland development. This allowed her to finally become a professor at Lund University.

In human anatomy, superior epigastric artery refers to a blood vessel that carries oxygenated blood and arises from the internal thoracic artery (referred to as the internal mammary artery in the accompanying diagram). It anastomoses with the inferior epigastric artery at the umbilicus and supplies the anterior part of the abdominal wall and some of the diaphragm. Along its course, it is accompanied by a similarly named vein, the superior epigastric vein.

In females that are not lactating, when M cells recognize antigen in the gut, they stimulate production of many Immunoglobulin A (IgA) antibodies. These antibodies are released into the gut mucosa, salivary glands, and lymph nodes. However, in females that are lactating, M cells recognize antigen and IgA is directed from the gut to the mammary gland. IgA traveling from the gut to breast milk supply is controlled by hormones, chemokines, and cytokines.

Porpoises are fully aquatic creatures. Females deliver a single calf after a gestation period lasting about a year. Calving takes place entirely under water, with the foetus positioned for tail-first delivery to help prevent drowning. Females have mammary glands, but the shape of a newborn calf's mouth does not allow it to obtain a seal around the nipple— instead of the calf sucking milk, the mother squirts milk into the calf's mouth.

The rate at which breast cancer (ductal carcinoma in situ or invasive mammary carcinoma (all breast cancer except DCIS and LCIS)) is found at the time of a surgical (excisional) biopsy, following the diagnosis of ADH on a core (needle) biopsy varies considerably from hospital-to-hospital (range 4-54%). In two large studies, the conversion of an ADH on core biopsy to breast cancer on surgical excision, known as "up-grading", is approximately 30%.

They will investigate how endocrine disrupting agents modulate the activity of fibroblasts in high and low mammographic density breast tissue. They use a 3D in vitro model of the human mammary gland. By identifying how oestrogen mimics effect human fibroblasts from areas of different breast density it will be possible to identify how the drives breast cancer development. She has published extensively on breast cancer and has a h-index of over 40.

HIV infected individuals who naturally suppress viral replication have elevated levels of p21 and its associated mRNA. p21 expression affects at least two stages in the HIV life cycle inside CD4 T cells, significantly limiting production of new viruses. Metastatic canine mammary tumors display increased levels of p21 in the primary tumors but also in their metastases, despite increased cell proliferation. Mice that lack the p21 gene gain the ability to regenerate lost appendages.

Lizzie (Noureen DeWulf) is the delivery girl for Pita Palace. She makes a delivery for Jeff and Lester at the beginning of the episode and hangs out for a bit, where they film her on "Mammary Cam" before she leaves. While Chuck is being interrogated by Big Mike and Conway, she arrives again. After being left alone, Chuck overhears Lizzie mention to the Buy More crew that this is Jeff and Lester's 30th delivery.

Teats protruding from the udder of a cow Part of a milking device that fits over the teats of a cow. A teat is the projection from the mammary glands of mammals from which milk flows or is ejected for the purpose of feeding young. In many mammals the teat projects from the udder. The number of teats vary by mammalian species and often corresponds to the size of an average litter for that animal.

Mice can also over-groom when stressed, leading to skin irritations and fur loss. Older mice are susceptible to tumors, especially breast cancer in females, as the mammary tissue is distributed around much of the body. Persistent problems should be referred to a veterinarian, although finding a veterinarian with experience in treating mice can be difficult. Like people, fancy mice can become obese if they overeat and do not get enough physical activity.

Staphylococcus spp. are a mostly benign group of bacteria that commonly reside on the top of the skin, but cuts and scratches from social and hierarchical fighting can open up the pathways for them to cause ulcerative dermatitis. There is some evidence that spayed female rats ("does") are less likely to develop mammary and pituitary tumors than non-spayed females. Research into prevention of common diseases and health issues in rats is on-going.

Mammals are a class of vertebrates that contain mammary glands which secrete milk that nourishes their offspring. This maternal behavior is unique from all other vertebrate classes. The basic maternal care patterns in mammals involve the internal incubation during gestation, the delivery of young, and maternal care until the young are weaned. The way a female mammal cares for their young depends on the level of maturation of the offspring at birth.

In humans, fatty acids are formed from carbohydrates predominantly in the liver and adipose tissue, as well as in the mammary glands during lactation. The pyruvate produced by glycolysis is an important intermediary in the conversion of carbohydrates into fatty acids and cholesterol. This occurs via the conversion of pyruvate into acetyl-CoA in the mitochondrion. However, this acetyl CoA needs to be transported into cytosol where the synthesis of fatty acids and cholesterol occurs.

The Bmi-1 expression interacts with several signaling containing Wnt, Akt, Notch, Hedgehog and receptor tyrosine kinase (RTK) pathway. In Ewing sarcoma family of tumors (ESFT), the knockdown of BMI-1 gene would greatly influence the Notch and Wnt signaling pathway which are important for ESFT formation and development. Bmi-1 was shown to mediate the effect of Hedgehog signaling pathway on mammary stem cell proliferation. Bmi-1 also regulates multiple downstream factors or genes.

Expression of Shh (Sonic hedgehog) upregulates the production of BMI1, a component of the PcG complex that recognizes H3K27me3. This occurs in a Gli-dependent manner, as Gli1 and Gli2 are downstream effectors of the Hedgehog signaling pathway. In culture, Bmi1 mediates the Hedgehog pathway's ability to promote human mammary stem cell self-renewal. In both humans and mice, researchers showed Bmi1 to be highly expressed in proliferating immature cerebellar granule cell precursors.

In realizing the breast-reduction corrections, the plastic surgeon takes anatomic and histologic account of the biomechanical, load-bearing properties of the glandular, adipose, and skin tissues that compose and support the breast; among the properties of the soft tissues of the breast is near-incompressibility (Poisson's ratio of ∼0.5). # Rib cage. The 2nd, 3rd, 4th, 5th, and 6th ribs of the thoracic cage are the structural supports for the mammary glands. # Chest muscles.

Both non-specific immune stimuli, like cytokines and other immunostimulators, and vaccines containing a specific antigen were active in mouse models; combinations of both types of agents yielded the best results, up to an almost complete, long-term block of carcinogenesis in models of aggressive cancer development.P. Nanni et al.. Combined allogeneic tumor cell vaccination and systemic interleukin 12 prevents mammary carcinogenesis in HER-2/neu transgenic mice. J. Exp. Med. 194: 1195-1206, 2001.

FANCD2 mutant mice have a significantly increased incidence of tumors including ovarian, gastric and hepatic adenomas as well as hepatocellular, lung, ovarian and mammary carcinomas. Humans with a FANCD2 deficiency have increased acute myeloid leukemia, and squamous cell carcinomas (head and neck squamous cell carcinomas and anogenital carcinomas).. Lung squamous tumors express high levels of FANCD2 and members of Fanconia anemia pathway. FANCD2 monoubiquitination is also a potential therapeutic target in the treatment of cancer.

The Agency concluded that the risk was increased by 70%, based on epidemiological studies and the fact that there are many mammary carcinogens in secondhand smoke. The following year (2006) the US Surgeon GeneralU.S. Department of Health and Human Services. "The Health Consequences of Involuntary Exposure to Tobacco Smoke: A Report of the Surgeon General", 2006 identified the same risk increase and concluded that the evidence is "suggestive," one step below causal.

When used on males, these drugs can reduce sex drive, compulsive sexual fantasies, and capacity for sexual arousal. Life-threatening side effects are rare, but some users show increases in body fat and reduced bone density, which increase long-term risk of cardiovascular disease and osteoporosis. They may also experience gynecomastia (development of larger-than-normal mammary glands in males); full development is less common unless chemical castration is combined with feminizing oestrogen therapy.

Alternatively, A. caninum larvae evading exit from the circulation at the lungs may instead be carried to the mammary glands and transmitted from the mother in her colostrum or milk to her pups; infection then proceeds in an identical manner as infection by ingestion from the environment. Infected mothers have been found to only rarely give prenatal transmission to pups, while the likelihood of causing transmission via the lactational route during nursing is much higher.

He offered the intended victims a ride in his personal car, then brought them to a deserted place and killed them. After the murders, Cheryomukhin cut off their mammary glands and external genitalia from the victims. In those years in the Rostov Oblast, another killer was operating - Andrei Chikatilo. His search involved a whole team of investigators from the Prosecutor's Office of the RSFSR, there was an operation named "Lesopolosa" to catch the killer.

Based on NCBI GEO expression profiles and EST analyses, the protein appears to be narrowly expressed throughout human tissues. It is highly expressed in bone marrow, CD4+ and CD8+ T cells, lymph node, mammary gland, spleen, stomach, thyroid, and small intestine tissue. Expression is elevated in cases of early T-cell precursor acute lymphoblastic leukemia and lowered in breast cancer cells that are treated with estrogen, suggesting an interaction between the protein and estrogen.

An important human paralog of FAM89A is FAM89B, located on human chromosome 11 at map position 11q13.1. FAM89B is also known as, Leucine Repeat Adaptor Protein 25 (LRAP25) and Mammary Tumor Virus Receptor Homolog 1 (MTVR1). Orthologs of FAM89A, but not FAM89B, are present in bivalves, crinoids, hemichordates, starfish, and horseshoe crabs. Orthologs of FAM89B, but not FAM89A, are present in brachiopods and priapulids, The paralogs likely split around 736 million years ago.

Sterneck began her independent research with an NCI-Scholar grant before being recruited as a principal investigator to the National Cancer Institute (NCI) in 2003. She is a senior investigator and head of the molecular mechanisms in development section. Sterneck's research investigates signaling pathways with emphasis on pro-inflammatory molecules in breast epithelial cells and cells of the tumor microenvironment. She studies cell signaling pathways that regulate mammary gland development and tumorigenesis.

Estradiol is rapidly distributed throughout the body, with a distribution phase of about 6 minutes following intravenous injection. Estradiol is taken up into cells via passive diffusion due to its lipophilicity. Due to binding to the ERs, estradiol is preferentially concentrated in tissues with the highest ER content. In animals, these tissues have included the uterus, vagina, mammary glands, pituitary gland, hypothalamus, other brain regions, adipose tissue, liver, and adrenal glands, among other tissues.

Furthermore, some miRNA's are epigenetically silenced early on in breast cancer, and therefore these miRNA's could potentially be useful as tumor markers. The epigenetic silencing of miRNA genes by aberrant DNA methylation is a frequent event in cancer cells; almost one third of miRNA promoters active in normal mammary cells were found hypermethylated in breast cancer cells - that is a several fold greater proportion than is usually observed for protein coding genes.

Tumor protein p63 is a member of the p53 family of transcription factors. p63 -/- mice have several developmental defects which include the lack of limbs and other tissues, such as teeth and mammary glands, which develop as a result of interactions between mesenchyme and epithelium. TP63 encodes for two main isoforms by alternative promoters (TAp63 and ΔNp63). ΔNp63 is involved in multiple functions during skin development and in adult stem/progenitor cell regulation.

One of MMP9's most widely associated pathologies is the relationship to cancer, due to its role in extracellular matrix remodeling and angiogenesis. For example, its increased expression was seen in a metastatic mammary cancer cell line. Gelatinase B plays a central role in tumor progression, from angiogenesis, to stromal remodeling, and ultimately metastasis. However, because of its physiologic function, it may be difficult to leverage Gelatinase B inhibition into cancer therapy modalities.

A glass of milk Cows in a rotary milking parlor Milk is a nutrient-rich liquid food produced in the mammary glands of mammals. It is the primary source of nutrition for infant mammals (including humans who are breastfed) before they are able to digest other types of food. Early-lactation milk contains colostrum, which carries the mother's antibodies to its young and can reduce the risk of many diseases. It contains many other nutrients including protein and lactose.

Oltipraz is an organosulfur compound belonging to the dithiolethione class. It acts as a schistosomicide and has been shown in rodent models to inhibit the formation of cancers in the bladder, blood, colon, kidney, liver, lung, pancreas, stomach, and trachea, skin, and mammary tissue. Clinical trials of oltipraz have failed to demonstrate efficacy and have shown significant side effects, including neurotoxicity and gastrointestinal toxicity. Oltipraz has also been shown to generate superoxide radical, which can be toxic.

Colostrinin was originally identified by scientists working in Poland in the 1970s. Colostrinin is derived from colostrum, which is present in the pre-milk fluid produced from mammary glands in the first few days after parturition. It is also known as proline-rich polypeptides, since sequence analysis of the peptides present in this mixture reveals an unusually high proportion of this amino acid residue. The amino acid compositions of Colostrinin from ovine, bovine, and human colostrum are very similar.

A basic cladogram of the origin of mammals. Important developments in the transition from reptile to mammal were the evolution of warm-bloodedness, of molar occlusion, of the three-ossicle middle ear, of hair, and of mammary glands. By the end of the Triassic, there were many species that looked like modern mammals and, by the Middle Jurassic, the lineages leading to the three extant mammal groups -- the monotremes, the marsupials, and the placentals -- had diverged.

Activation of AMPK-related kinases by LKB1 plays vital roles maintaining cell polarity thereby inhibiting inappropriate expansion of tumour cells. A picture from current research is emerging that loss of LKB1 leads to disorganization of cell polarity and facilitates tumour growth under energetically unfavorable conditions. Loss of LKB1 activity is associated with highly aggressive HER2+ breast cancer. HER2/neu mice were engineered for loss of mammary gland expression of Lkb1 resulting in reduced latency of tumorgenesis.

She sent samples to scientists and corresponded with experimental pathologist Leo Loeb, who identified the lesions as malignant. Lathrop began developing inbred strains around 1910. Loeb and Lathrop performed experiments at her farm and the pair authored 10 journal articles from 1913 to 1919, including those published in the Journal of Cancer Research and the Journal of Experimental Medicine. They established that ovariectomies reduced the incidence of mammary tumors and that tumor susceptibility varied in different strains of mice.

Carveol is a natural unsaturated, monocyclic monoterpenoid alcohol that is a constituent of spearmint essential oil in the form of cis-(−)-carveol. It is a colorless fluid soluble in oils, but insoluble in water and has an odor and flavor that resemble those of spearmint and caraway. Consequently, it is used as a fragrance in cosmetics and as a flavor additive in the food industry. It has been found to exhibit chemoprevention of mammary carcinogenesis (prevents breast cancer).

Flemming named this degenerative process "chromatolysis" to describe the gradual disintegration of nuclear components. The process he described now fits with the relatively new term, apoptosis, to describe cell death. Around the same time of Flemming's research, chromatolysis was also studied in the lactating mammary glands and in breast cancer cells. From observing the regression of ovarian follicles in mammals, it was argued that a necessary cellular process existed to counterbalance the proliferation of cells by mitosis.

The conditional gene knockout method is often used to model human diseases in other mammals. It has increased scientists’ ability to study diseases, such as cancer, that develop in specific cell types or developmental stages. It is known that mutations in the BRCA1 gene are linked to breast cancer. Scientists used conditional gene knockout to delete the BRCA1 allele in mammary gland tissue in mice and found that it plays an important role in tumour suppression.

Use of short interfering RNA (siRNA) of PTPkappa to reduce PTPkappa protein expression in the mammary epithelial cell line, MCF10A, resulted in increased cell proliferation. PTPkappa expression, conversely, was demonstrated to reduce cell proliferation in Chinese hamster ovary cells. The mechanism proposed to explain the influence of PTPkappa on cell proliferation is via PTPkappa dephosphorylation of the EGFR on tyrosines 1068 and 1173 directly. The reduction of PTPkappa expression in CHO cells with PTPkappa siRNA increased EGFR phosphorylation.

A lactotropic cell (also known as prolactin cell, epsilon acidophil, lactotrope, lactotroph, mammatroph, mammotroph) is a cell in the anterior pituitary which produces prolactin in response to hormonal signals including dopamine which is inhibitory and thyrotropin-releasing hormone which is stimulatory. Other regulators include oxytocin, estrogen and progesterone. Prolactin is involved in the maturation of mammary glands and their secretion of milk in association with oxytocin, estrogen, progesterone, glucocorticoids, and others. Prolactin has numerous other effects in both sexes.

Amastia, particularly if it is bilateral, often related to various syndromes, including ectodermal dysplasia and Poland's syndrome, which is characterised by anomalies of underlying mesoderm and abnormal pectoral muscle respectively. Other syndromes, such as FIG4 associated Yunis Varon syndrome (MIM 216340), acro-der-mato-ungual- lacrimal-tooth (ADULT) syndrome, TP63 associated limb mammary syndrome (MIM 603543), TBX3 associated ulnar syndrome (MIM 181450) and KCTD1 associated scalp-ear-nipple syndrome (MIM 181270) have also been clinically observed.

Long acting antibiotics used during this time work to treat any existing intra-mammary infections while also providing preventing new infections. Minimizing stress is important during the dry period as it can negatively impact appetite and immunity. Social stress can be reduced by avoiding large pen or herd changes so the social hierchy is not disrupted. Some producers may chose to completely separate dry cows from the rest of the herd to ensure they are not milked.

Rotter's lymph nodes are small interpectoral lymph nodes located between the pectoralis major and pectoralis minor muscles. They receive lymphatic fluid from the muscles and the mammary gland, and deliver lymphatic fluid to the axillary lymphatic plexus. These lymph nodes are susceptible to breast cancer, as the cancer sometimes spreads (metastasizes) to the interpectoral lymph nodes. Rotter's lymph nodes are named after German surgeon Josef Rotter (1857-1924), who described them in the early 19th century.

Estrone is biosynthesized from cholesterol. The principal pathway involves androstenedione as an intermediate, with androstenedione being transformed into estrone by the enzyme aromatase. This reaction occurs in both the gonads and in certain other tissues, particularly adipose tissue, and estrone is subsequently secreted from these tissues. In addition to aromatization of androstenedione, estrone is also formed reversibly from estradiol by the enzyme 17β-hydroxysteroid dehydrogenase (17β-HSD) in various tissues, including the liver, uterus, and mammary gland.

The underbelly is white, with bands that extend onto the lower rear of the body. Small white patches are located just behind the pectoral fins and a single white patch extends between these fins on the chest. Sexual dimorphism is minimal, however variation in the shape of the white patch covering the genital slit is distinct between genders. In males, the patch ends in a point, but in females widens out to cover the mammary slits.

Estradiol produces cell proliferation in both normal and malignant breast epithelial tissue. However, GPER knockout mice show no overt mammary phenotype, unlike ERα knockout mice, but similarly to ERβ knockout mice. This indicates that although GPER and ERβ play a modulatory role in breast development, ERα is the main receptor responsible for estrogen-mediated breast tissue growth. GPER is expressed in germ cells and has been found to be essential for male fertility, specifically, in spermatogenesis.

The ectoderm forms the skin, nails, hair, cornea, lining of the internal and external ear, nose, sinuses, mouth, anus, teeth, pituitary gland, mammary glands, eyes, and all parts of the nervous system. Approximately 18 days after fertilization, the embryo has divided to form much of the tissue it will need. It is shaped like a pear, where the head region is larger than the tail. The embryo's nervous system is one of the first organic systems to grow.

Its ectodomain consists of a collagen- binding discoidin domain followed by ~200 residues of unknown structure. It binds fibril-forming collagens and primarily type IV collagen, but also collagen of types I, VI, VIII. It is expressed mainly in epithelial cells and leukocytes and expression rate changes due to cell cycle phase. Functions include: mammary gland development; arterial wound repair; regulation of cell proliferation, cell adhesion and MMP expression; kidney function, differentiation and function of leukocytes.

Myoepithelial cells (sometimes referred to as myoepithelium) are cells usually found in glandular epithelium as a thin layer above the basement membrane but generally beneath the luminal cells. These may be positive for alpha smooth muscle actin and can contract and expel the secretions of exocrine glands. They are found in the sweat glands, mammary glands, lacrimal glands, and salivary glands. Myoepithelial cells in these cases constitute the basal cell layer of an epithelium that harbors the epithelial progenitor.

Satan's Angel started dancing in San Francisco in 1961, after winning an amateur strip contest at North Beach nightclub Moulin Rouge. Her full moniker is Satan's Angel, the Devil's Own Mistress, Queen of the Fire Tassels. She has also danced under the stage names Tassel Tossin' Angel, Angel Dahl, Angel the Body, Satana Angel, and Satin Angel. Satan's Angel's signature act is to light her tassels aflame, "then extinguishing the flames by means of strenuous mammary rotation".

In some breeding environments portability is also desirable. This is typically achieved through light weight design and emphasis on simple setup and takedown. Commercially available whelping boxes often feature accommodations for accessories such as heat control devices and IP camera attachment. The sides of the box are designed to be high enough to safely contain the puppies, yet low enough to allow the mother to enter and leave comfortably, with consideration given to her protruding mammary glands.

Each cover hair is associated with an arrector pilli muscle, a hair follicle, a ring of sebaceous glands and a sweat gland. Females have cone-shaped, four-chambered mammary glands that are long with a base diameter of . These glands can produce milk with up to 90% water content even if the mother is at risk of dehydration. Camel kidney (longitudinal cut) The heart weighs around ; it has two ventricles with the tip curving to the left.

Newborn males and females can be distinguished on close examination as the anogenital distance in males is about double that of the female. From the age of about 10 days, females have five pairs of mammary glands and nipples; males have no nipples. When sexually mature, the most striking and obvious difference is the presence of testicles on the males. These are large compared to the rest of the body and can be retracted into the body.

Chk1 has a regulatory role in the spindle checkpoint however the relationship is less clear as compared to checkpoints in other cell cycle stages. During this phase the Chk1 activating element of ssDNA can not be generated suggesting an alternate form of activation. Studies on Chk1 deficient chicken lymphoma cells have shown increased levels of genomic instability and failure to arrest during the spindle checkpoint phase in mitosis. Furthermore, haploinsufficient mammary epithelial cells illustrated misaligned chromosomes and abnormal segregation.

C9orf43 is expressed in health states including cervical tumors, normal tumors, and soft tissue/muscle tumors. C9orf43 is expressed at high levels in sperm cells compared to lower relative expression in teratozoospermia. Greater relative expression of C9orf43 is seen in the hyperplastic enlarged lobular unit of the mammary gland as compared to the normal terminal duct lobular unit. C9orf43 expression varies in megakaryocyte differentiation as seen in peripheral blood CD34 plus cells as compared to CHRF-288-11 cells.

In normal tissue, STAT5a mediates effects of prolactin in mammary glands. In breast cancer, STAT5a signaling is important for maintain tumor differentiation and suppressing disease progression. Studies originally showed a correlation between high STAT5a expression and tumor differentiation in mice models, but histopathological analysis of human breast cancer tissue has shown a different trend. It was shown that low nuclear levels of STAT5a was associated with unfavorable clinical outcomes and cancer progression independent of STAT5b expression.

When born, calves are generally 10 to 15 feet long. They feed off their mothers milk, which is produced and fed to their calves through mammary gland slits. The calf is able to roll its tongue into a tube and siphon in the milk that is ejected into the water. Occasionally pods of dolphins are found trailing mothers and their calves, and it has been speculated that they are consuming be leftover milk that the calf does not eat.

In Gabon, females were recorded to give birth in the long wet season and at the onset of the dry season between September and January. The female usually gives birth after a gestation period of 2–3 months. A litter consists of up to four young that are suckled for around three months. While she has suckling young the female's mammary glands produce an orange-yellow liquid which discolours her abdomen and the young civets' fur.

The second activity is restricted to lactating mammary tissues where the enzyme forms a heterodimer with alpha-lactalbumin to catalyze UDP-galactose + D-glucose <=> UDP + lactose. The two enzymatic forms result from alternate transcription initiation sites and post-translational processing. Two transcripts, which differ only at the 5' end, with approximate lengths of 4.1 kb and 3.9 kb encode the same protein. The longer transcript encodes the type II membrane- bound, trans-Golgi resident protein involved in glycoconjugate biosynthesis.

Translationally controlled tumor protein was first discovered in 1989 as a cDNA sequence obtained from a human mammary carcinoma cDNA library with proves derived from the translationally controlled, growth-related mouse tumor protein TCTP. TCTP was originally described as a growth related protein of tumor cells. Its mRNA accumulates in translationally repressed postpolysomal mRNP-complexes. Research in 1997 shown that TCTP is not a tumor- or tissue- specific protein, but is expressed ubiquitously from plants to mammals.

Pseudopregnancy has been suggested for use in decreasing the risk of breast cancer in women, though this has not been assessed in clinical studies. Natural pregnancy before the age of 20 has been associated with a 50% lifetime reduction in the risk of breast cancer. Pseudopregnancy has been found to produce decreases in risk of mammary gland tumors in rodents similar to those of natural pregnancy, implicating high levels of estrogen and progesterone in this effect.

Maternal exposure to BPA during lactation decreased time to first tumor latency and increased the number of DMBA-induced mammary tumors in female offspring. If these effects found in rodents carry over to humans, even minimal exposure to BPA could cause an increased risk for breast cancer. The elevated incidence of breast cancer in women has been associated with prolonged exposure to high levels of estrogens. Xenoestrogens, such as BPA have the capacity to perturb normal hormonal actions.

Mammary analogue secretory carcinoma (MASC) (also termed MASCSG; the "SG" subscript indicates salivary gland)) is a salivary gland neoplasm that shares a genetic mutation with certain types of breast cancer. MASCSG was first described by Skálová et al. in 2010. The authors of this report found a chromosome translocation in certain salivary gland tumors that was identical to the (12;15)(p13;q25) fusion gene mutation found previously in secretory carcinoma, a subtype of invasive ductal carcinoma of the breast.

One area of particular interest in terms of the effects of progesterone in women is breast development. Estrogens are responsible for the development of the ductal and connective tissues of the breasts and the deposition of fat into the breasts during puberty in girls. Conversely, high levels of progesterone, in conjunction with other hormones such as prolactin, are responsible for the lobuloalveolar maturation of the mammary glands during pregnancy. This allows for lactation and breastfeeding after childbirth.

Practice Manager Deborah isn't very welcoming and her encounter with Sarah leaves feathers severely ruffled. Sarah's first client of the day is a border collie which needs a mammary strip - a straightforward operation but tricky without an ultrasound. Fiona has the dog prepped, but when Sarah realises that the practice doesn't even have an ultrasound she freaks and walks out, heading back to David and London. Unknown to Sarah, her sly ex appears to be entertaining another woman.

Vasilii Ivanovich Kolesov (; 24 September 1904, Martyanovskaja village in Vologda Oblast – 2 August 1992, St. Petersburg) was one of the pioneers of global cardiac surgery. He was the first to perform successful internal coronary artery bypass surgery using mammary artery–coronary artery anastomosis in 1964. Also in 1964, he performed the first successful coronary bypass using a standard suture technique. Kolesov was a recipient of the USSR State Prize and Honoured Worker of Science in USSR (1964).

Intralobar sequestration (ILS) in which the lesion is located within a normal lobe and lacks its own visceral pleura. Extralobar sequestration (ELS) in which the mass is located outside the normal lung and has its own visceral pleura The blood supply of 75% of pulmonary sequestrations is derived from the thoracic or abdominal aorta. The remaining 25% of sequestrations receive their blood flow from the subclavian, intercostal, pulmonary, pericardiophrenic, innominate, internal mammary, celiac, splenic, or renal arteries.

The ID4 promoter region has been found to be hypermethylated and its mRNA suppressed in breast cancer cell lines including that of primary breast cancers. Patients with invasive carcinomas have shown ID4 expression in their breast cancer specimens. This has been identified as a significant risk factor in nodal metastasis. ID4 is constitutively expressed in normal human mammary epithelium but found to be suppressed in ER positive breast carcinomas and preneoplastic lesions. ER negative carcinomas also show ID4 expression.

She came to conclude that developing tumors was an inherited trait. Lynch also looked at tumors in the lungs of these mice, also coming to the conclusion that the tendency to accumulate tumors in both the mammary and lung tissue resulted from dominant inherited traits. Lynch's work was often doubted by other scientific experts during this time. Lynch is also given credit for pioneering her so-called albino Swiss mouse, which she used as test subjects for experiments.

Types of parental care and the amount of resources invested by parents vary considerably across the animal kingdom. The evolution of male-only, female- only, biparental or alloparental care in different groups of animals may be driven by multiple factors. Firstly, different groups may have diverse physiological or evolutionary constraints that may predispose one sex to care more than the other. For example, mammary glands may make female mammals preadapted to exclusively provide nutritional care to young.

Ductal carcinoma in situ (DCIS) literally means groups of "cancerous" epithelial cells which remained in their normal location (in situ) within the ducts and lobules of the mammary gland. Clinically, it is considered a premalignant (i.e. potentially malignant) condition, because the biologically abnormal cells have not yet crossed the basement membrane to invade the surrounding tissue. When multiple lesions (known as "foci" of DCIS) are present in different quadrants of the breast, this is referred to as "multicentric" disease.

Viral promoters are often used for constitutive expression in plasmids and in viral vectors because they normally force constant transcription in many cell lines and types reliably. Inducible expression depends on promoters that respond to the induction conditions: for example, the murine mammary tumor virus promoter only initiates transcription after dexamethasone application and the Drosophilia heat shock promoter only initiates after high temperatures. Some vectors are designed for transcription only, for example for in vitro mRNA production. These vectors are called transcription vectors.

By knocking in/knocking out specific genes by homologous recombination, the extent of metastasis can be measured and new target genes identification can be achieved e.g. a gene that consistently regulates metastatic behavior of cancer cells is TGF-β1. Acute ablation of TGF-β signaling in MMTV-PyMT mammary tumor cells leads to a five-fold increase in lung metastasis. Certain enhancer regions can also be analyzed and can be determined to be a crucial part of cell proliferation e.g.

The tail measures in the male and in the female. An adult male's hind feet measure , and an average female's hind feet measure . There are four mammary glands: two in the inguinal region and two in the pectoral region, each supplying a pair of nipples. Morphologically, it most closely resembles Botta's pocket gopher; differentiation can be made based on the concavity of the inner surface of the pterygoids, small claws, more uniform fur coloring and exoccipital groove of the camas pocket gopher.

As a mammary gland, the breast comprises lobules (milk glands at each lobe-tip) and the lactiferous ducts (milk passages), which widen to form an ampulla (sac) at the nipple. # Adipose tissue. The fat tissue of the breast is composed of lipidic fluid (60–85% weight) that is 90–99 per cent triglycerides, free fatty acids, diglycerides, cholesterol phospholipids, and minute quantities of cholesterol esters, and monoglycerides; the other components are water (5–30% weight) and protein (2–3% weight). # The skin envelope.

Cross-section scheme of the mammary gland. The presence of breast implants currently presents no contraindication to breast feeding, and no evidence to support that the practice may present health issues to a breast feeding infant is recognized by the USFDA. Women with breast implants may have functional breast-feeding difficulties; mammoplasty procedures that feature periareolar incisions are especially likely to cause breast-feeding difficulties. Surgery may also damage the lactiferous ducts and the nerves in the nipple-areola area.

C7orf43 has also been identified as a target gene of the transcription factor AP-2 gamma (TFAP2C). TFAP2C has been shown to be involved in the development, differentiation, and oncogenesis of mammary tissues. Specifically, TFAP2C has a role in breast carcinoma through its regulatory effect to ESR1 and ERBB2, both of which are receptors whose aberrations have been associated with breast carcinomas. TFAP2C has also been shown to have an oncogenic role by promotion of cell proliferation and tumour growth in neuroblastoma.

When functional, it creates dun coloring, including the primitive markings, and when recessive, a horse is not dun. In humans and lab mice, TBX3 is critical to development. Abnormalities are linked to a collection of developmental defects called ulnar–mammary syndrome, and the null allele (being unable to produce any TBX3 at all) is thought to be embryonic lethal. In non-dun horses, the TBX3 protein is still functional, and is still produced in most cells, but not expressed in the hair cortex.

Tegumental angiomyxoma-neurothekeoma (TAN syndrome) is a syndrome, an acronym, and eponym proposed by Malaysian ophthalmologist of Chinese Descent, Tan Aik Kah (b. June 1975). Angiomyxomas are associated with LAMB (lentigines, atrial myxomas, muco-cutaneous myxomas, and blue naevi) syndrome, NAME (nevi, atrial myxoma, myxoid neurofibromas, and ephelides) syndrome and Carney syndrome (atrial, cutaneous and mammary myxomas, lentigines, blue naevi, endocrine disorders and testicular tumours). TAN syndrome is characterized by multiple superficial angiomyxoma and neurothekeoma confined only to the skin (tegument).

When the PMCA fails to function properly, disease can result. Improperly functioning PMCA proteins have been found associated with conditions such as sensorineural deafness, diabetes, and hypertension. In excitotoxicity, a process in which excessive amounts of the neurotransmitter glutamate overactivate neurons, resulting in excessive influx of Ca2+ into cells, the activity of the PMCA may be insufficient to remove the excess Ca2+. In breast tissue, mammary epithelial cells express PMCA2, which transports calcium across the apical surface of the cells into milk.

TECAB surgery uses the da Vinci tele-robotic Stereoscopic 3-D Imaging system. The system consists of a robotic "slave" system at the bedside. The robot relays its information to an external surgical control unit, where a cardiac surgeon has a three-dimensional view of the chest cavity, and twin controllers for the robotic arms. The procedure frequently involves grafting of the internal mammary artery to the diseased coronary artery, and therefore does not require external harvesting of blood vessels.

It is hypothesized that other pleiotropic effects associated with the V370A allele were favored by natural selection to help promote the presence of the allele and thus the emergence of shovel-shaped incisors. One of these associated traits is increased ductal branching in the mammary gland, which improves nutrient transport in breastmilk. This may likely have conferred a survival advantage to those with the allele during the Last Glacial Maximum in certain environments with high altitudes and low Vitamin D.

The protein encoded by this gene is a member of the LAR protein tyrosine phosphatase-interacting protein (liprin) family. Liprins interact with members of LAR family of transmembrane protein tyrosine phosphatases, which are known to be important for axon guidance and mammary gland development. This protein binds to the intracellular membrane-distal phosphatase domain of tyrosine phosphatase LAR, and appears to localize LAR to cell focal adhesions. This interaction may regulate the disassembly of focal adhesion and thus help orchestrate cell-matrix interactions.

Nitrofurans are broad spectrum antibiotics, being effective against Gram-positive and Gram-negative bacteria. In 1991, the FDA withdrew several approved food animal nitrofuran products as a result of research showing nitrofurazone, one of the nitrofurans, can produce mammary tumors in rats and ovarian tumors in mice. The FDA also concluded that some people may be hypersensitive to this product."Detention Without Physical Examination of Seafood Products Due to Nitrofurans", Import Alert #16-129, published 06/29/2011 (last visited Oct. 2011).

As type II membrane proteins, they have an N-terminal hydrophobic signal sequence that directs the protein to the Golgi apparatus and which then remains uncleaved to function as a transmembrane anchor. By sequence similarity, the beta4GalTs form four groups: beta4GalT1 and beta4GalT2, beta4GalT3 and beta4GalT4, beta4GalT5 and beta4GalT6, and beta4GalT7. The enzyme encoded by this gene synthesizes N-acetyllactosamine in glycolipids and glycoproteins. Its substrate specificity is affected by alpha-lactalbumin but it is not expressed in lactating mammary tissue.

Altered JAK-STAT signalling can also be involved in developing breast cancer. JAK-STAT signalling in mammary glands (located within breasts) can promote cell division and reduce cell apoptosis during pregnancy and puberty, and therefore if excessively activated, cancer can form. High STAT3 activity plays a major role in this process, as it can allow the transcription of genes such as BCL2 and c-Myc, which are involved in cell division. Mutations in JAK2 can lead to leukaemia and lymphoma.

During the dry period changes begin to occur within the mammary gland which correspond to milk synthesis and secretion. This period is important for the rejuvenation of new udder tissue in preparation for lactation. It also provides the cow the opportunity to eliminate mastitis causing pathogens within the udder. In the early stages of the non-lactating period (between 12 and 24 hours) there is decrease of milk protein and cell survival genes, resulting in a loss of epithelial cells.

When gigantomastia occurs in young women during puberty, the medical condition is known as juvenile macromastia or juvenile gigantomastia and sometimes as virginal breast hypertrophy or virginal mammary hypertrophy. Along with the excessive breast size, other symptoms include red, itchy lesions and pain in the breasts. A diagnosis is made when an adolescent's breasts grow rapidly and achieve great weight, usually soon after her first menstrual period. Some doctors suggest that the rapid breast development occurs before the onset of menstruation.

Surprisingly, both RAPTA-C and RAPTA-T showed the ability to inhibit lung metastasis in mice bearing middle cerebral artery mammary carcinoma (by measuring the number and weight of the metastases), whilst having small effect on primary tumor. The only ruthenium complex which proves the ability against metastasis was NAMI-A, and this work has high practical application in chemotherapy since the removal of primary tumor can be done through frequent surgery while the number of metastasis treatments are limited.

Several arteries and veins can be used, however internal mammary artery grafts have demonstrated significantly better long- term patency rates than great saphenous vein grafts. In patients with two or more coronary arteries affected, bypass surgery is associated with higher long-term survival rates compared to percutaneous interventions. In patients with single vessel disease, surgery is comparably safe and effective, and may be a treatment option in selected cases. Bypass surgery has higher costs initially, but becomes cost-effective in the long term.

His archive is held at the Osler Library at McGill University. He is known for having developed a surgical procedure called the "Vineberg Procedure" which involved implanting the left mammary artery into the left ventricle of the heart. He first did this procedure in 1946 on an experimental basis and at the Royal Victoria Hospital in 1950. He published two books, How to Live with your Heart; the Family Guide to Heart Health (1975) and Myocardial Revascularization by Arterial/Ventricular Implants (1982).

After peak milk production her body condition will also steadily recover. Producers will typically continue to milk the cow until she is two months away from parturition then they will dry her off. Giving the cow a break during the final stages of pregnancy allows her mammary gland to regress and re-develop, her body condition to recover, and the calf to develop normally. Decreased body condition in the cow means she will not be as productive in subsequent milk cycles.

FOXA1 in breast cancer is highly correlated with ERα+, GATA3+, and PR+ protein expression as well as endocrine signaling. FOXA1 acts as a pioneer factor for ERa in ERα+ breast cancer, and its expression might identify ERα+ cancers that undergo rapid reprogramming of ERa signaling that is associated with poor outcomes and treatment resistance. Conversely, in ERα− breast cancer FOXA1 is highly correlated with low-grade morphology and improved disease free survival. FOXA1 is a downstream target of GATA3 in the mammary gland.

The milk fat globule is surrounded by a phospholipid trilayer containing associated proteins, carbohydrates, and lipids derived primarily from the membrane of the secreting mammary epithelial cell (lactocyte). This trilayer is collectively known as MFGM. While MFGM makes up only an estimated 2% to 6% of the total milk fat globule, it is an especially rich phospholipid source, accounting for the majority of total milk phospholipids. In contrast, the inner core of the milk fat globule is composed predominantly of triacylglycerols.

Every time a cow enters the parlor several things need to happen to ensure milk quality and cow health. First, the cow's udder must be cleaned and disinfected to prevent both milk contamination and udder infections. Then the milking technician must check each teat for signs of infection by observing the first stream of milk. During this processes, called stripping the teat, the milking technician is looking for any discoloration or chunkiness that would indicate mastitis, an infection in the cow's mammary gland.

Women who experience multiple pregnancies repeatedly stretch the skin envelope during engorgement while lactating. In addition, after the birth of each child, the voluminous milk glands diminish in size, contributing further to sagging. As a woman's breasts grow in size during repeated pregnancies, the Cooper's ligaments that maintain the position of the mammary glands against the chest, are stretched and gradually lose strength. Breast tissue and suspensory ligaments may also be stretched if the woman is overweight or loses and gains weight.

Of Pandas and People became the focus of a litigation and controversy in Dover, Pennsylvania in 2004 after the Dover Area School Board endorsed it as a reference book. The ensuing court case was dubbed the "Panda Trial" by the media in an allusion to the famous "Monkey Trial" of 1925."Of Behe and mammary glands ." York Daily Record, 20 October 2005 Although the board did not actually purchase the book, 60 copies were donated to the district by an anonymous party.

A Nigerian Dwarf milker in show clip. This doe is angular and dairy with a capacious and well supported mammary system. Goat breeders' clubs frequently hold shows, where goats are judged on traits relating to conformation, udder quality, evidence of high production, longevity, build and muscling (meat goats and pet goats) and fiber production and the fiber itself (fiber goats). People who show their goats usually keep registered stock and the offspring of award-winning animals command a higher price.

In terms of fur, however, desert animals have thick insulating coats that impede the conduction of heat towards the body. The coats are not uniformly distributed, but rather leave sparsely covered patches called "thermal windows" at the axilla, groin, scrotum, and mammary glands. Heat can be dissipated from thermal windows via convection and conduction. Similarly, desert birds have less feathers on the underwing and flank – heat stress induces some birds to raise their wings, increasing the surface area of exposed skin.

The OncoMouse or Harvard mouse is a type of laboratory mouse (Mus musculus) that has been genetically modified using modifications designed by Philip Leder and Timothy A Stewart, under "Inventor(s)". Consulted on February 22, 2008. of Harvard University to carry a specific gene called an activated oncogene (v-Ha-ras under the control of the mouse mammary tumor virus promoter). The activated oncogene significantly increases the mouse's susceptibility to cancer, and thus makes the mouse a suitable model for cancer research.

The OXTR protein belongs to the G-protein coupled receptor family, specifically Gq, and acts as a receptor for oxytocin. Its activity is mediated by G proteins that activate several different second messenger systems. Oxytocin receptors are expressed by the myoepithelial cells of the mammary gland, and in both the myometrium and endometrium of the uterus at the end of pregnancy. The oxytocin-oxytocin receptor system plays an important role as an inducer of uterine contractions during parturition and of milk ejection.

As a mammary gland, the breast comprises lobules (milk glands at each lobe-tip) and the lactiferous ducts (milk passages), which widen to form an ampulla (sac) at the nipple. # Adipose tissue. The fat tissue of the breast is composed of lipidic fluid (60–85% weight) that is 90–99 per cent triglycerides, free fatty acids, diglycerides, cholesterol phospholipids, and minute quantities of cholesterol esters, and monoglycerides; the other components are water (5–30% weight) and protein (2–3% weight). # Fatty tissue.

For example, group member connection has the potential to mitigate the potentially harmful effects of stressors. In macaques, social grooming has been proven to reduce heart rate. Social affiliation during a mild stressor was shown to correlate with lower levels of mammary tumor development and longer lifespan in rats, while lack of this affiliation was demonstrated to be a major risk factor. Grooming has also been shown to play an integral role in reducing tick load in wild baboons (Papio cynocephalus).

In contrast to the other AKRs, AKR1C3 has low catalytic efficiency for reduction of 5α-DHP. These AKRs are highly expressed in the human liver and mammary gland but have relatively modest expression in the human brain and uterus. 5α-DHP is an agonist of the progesterone receptor and a positive allosteric modulator of the GABAA receptor (albeit with an affinity for this receptor that is regarded as relatively low (in comparison to 3α-hydroxylated progesterone metabolites such as allopregnanolone and pregnanolone)).

Ductoscopy or mammary ductoscopy (also: breast duct endoscopy, galactoscopy) is a medical diagnostic procedure for viewing and collecting epithelial cells and other internal features of the milk ducts. It is capable of detecting smaller abnormalities than mammograms, MRI or ultrasound tests. Ductoscopy can be performed in a physician's office or as an outpatient in a clinic. A fiber optic scope less than a millimeter thick is inserted into the milk duct at the nipple and threaded deep into the breast through the duct.

The ERICH3 gene in humans is 105,628 bases and is encoded on the minus strand at position 31.1 on the short arm of chromosome 1 from base pair 75,033,795 bp to 75,139,422 bp from pter. C1orf173's function in humans is still unclear though there is a link between expression of this gene and several forms of cancer, such as breast cancer and skin sarcomas. C1orf173 is expressed in the brain, eye, lung, mammary gland, muscle, pituitary gland, testis, trachea, and uterus.

CircRNAs lack polyadenylated tail and therefore are predicted to be less prone to degradation by exonucleases. In 2015, Enuka et al. measured the half-lives of 60 circRNAs and their linear counterparts expressed from the same host gene and revealed that the median half-life of circRNAs of mammary cells (18.8–23.7 h) is at least 2.5 times longer than the median half- life of their linear counterparts (4.0–7.4 h). Generally, the lifetime of RNA molecules defines their response time.

Gardner syndrome is also associated with familial adenomatous polyposis and may manifest as aggressive fibromatosis (desmoid tumors) of the retroperitoneum.DeVita. Cancer, Principles and Practice of Oncology, 8th Ed. p. 1742. Desmoid tumors arise most frequently from the aponeurosis of the rectus abdominal muscle of multiparous women. The extra- abdominal form is rare and desmoids of the breast may arise in the mammary gland or may occur as an extension of a lesion arising from the muscles of the chest wall.

Corset-wearing cannot cause breast cancer. Occurring more frequently is a reduction of the size of the nipples. Victorians believed the corset caused mammary abscesses, a common inflammation of the connective tissue in the breast; however, mastitis is caused by bacteria, and thus there is no evidence supporting that clothing of any type alone could have led to the condition. These effects are only consistent with that of over-bust corsets and not relevant to those using under-bust only.

Liprin-beta-1 is a protein that in humans is encoded by the PPFIBP1 gene. The protein encoded by this gene is a member of the LAR protein-tyrosine phosphatase-interacting protein (liprin) family. Liprins interact with members of LAR family of transmembrane protein tyrosine phosphatases, which are known to be important for axon guidance and mammary gland development. It has been proposed that liprins are multivalent proteins that form complex structures and act as scaffolds for the recruitment and anchoring of LAR family of tyrosine phosphatases.

According to data on NCBI’s EST Abundance Profile page for KIAA1109, the gene is expressed in many different tissues in humans. Human expression is seen most predominately in parathyroid, muscle, ear, eye, mammary gland, lymph node, thymus in addition to 27 other tissues. KIAA1109 is also expressed in various disease states including 12 different tumors as well as bladder carcinoma, chondrosarcoma, glioma, leukemia, lymphoma, non-neoplasia, retinoblastoma tissues. KIAA1109 is expressed in all stages of development from embryoid body to adult, except in infants.

Because of high concentration of detergent, the CUBIC ca also partially diminishes the fluorescence or disturb ultrastructure of the tissue. CUBIC was optimized and used for wide spread of applications and tissues. In the mouse the method was used for mapping the brain activity, analysis of interactions between immune cells in lymph node, description of mammary stem cells behaving or for capturing 3D anatomy of liver, kidneys, lungs and heart. CUBIC was also modified and used for clearing of chicken embryos or marmoset brains.

Glycoside hydrolase family 22 CAZY GH_22 comprises lysozyme type C () lysozyme type i () and alpha-lactalbumins. Asp and/or the carbonyl oxygen of the C-2 acetamido group of the substrate acts as the catalytic nucleophile/base. Alpha-lactalbumin, is a milk protein that acts as the regulatory subunit of lactose synthetase, acting to promote the conversion of galactosyltransferase to lactose synthase, which is essential for milk production. In the mammary gland, alpha-lactalbumin changes the substrate specificity of galactosyltransferase from N-acetylglucosamine to glucose.

This technique is rarely used in cosmetic surgery due to high risk of animation deformities. #Prepectoral or subcutaneous: in a breast reconstruction following a skin- sparing or skin- and nipple-sparing mastectomy, the implant is placed above the pectoralis major muscle without dissecting it so that the implant fills directly the volume of the mammary gland that has been removed. To avoid the issue of capsular contracture, the implant is often covered frontally or completely with a mesh in biomaterial, either biological or synthetic.

CCL28 has also been implicated in the migration of IgA-expressing cells to the mammary gland, salivary gland, intestine and other mucosal tissues. It has also been shown as a potential antimicrobial agent effective against certain pathogens, such as Gram negative and Gram positive bacteria and the fungus Candida albicans. Human CCL28 is encoded by an RNA transcript of 373 nucleotides and a gene with four exons. The gene codes for a 127-amino acid CCL28 protein with a 22-amino acid N-terminal signal peptide.

Wnt proteins constitute a large family of secreted molecules that are involved in intercellular signalling during development. The name derives from the first 2 members of the family to be discovered: int-1 (mouse) and wingless (Drosophila). It is now recognised that Wnt signalling controls many cell fate decisions in a variety of different organisms, including mammals. Wnt signalling has been implicated in tumourigenesis, early mesodermal patterning of the embryo, morphogenesis of the brain and kidneys, regulation of mammary gland proliferation and Alzheimer's disease.

Spaying or neutering increases life expectancy: one study found neutered male cats live twice as long as intact males, while spayed female cats live 62% longer than intact females. Having a cat neutered confers health benefits, because castrated males cannot develop testicular cancer, spayed females cannot develop uterine or ovarian cancer, and both have a reduced risk of mammary cancer. Despite widespread concern about the welfare of free- roaming cats, the lifespans of neutered feral cats in managed colonies compare favorably with those of pet cats.

Ethinylestriol (EE3), or 17α-ethynylestriol, also known as 17α-ethynylestra-1,3,5(10)-triene-3,16α,17β-triol, is a synthetic estrogen which was never marketed. Nilestriol, the 3-cyclopentyl ether of ethinylestriol, is a prodrug of ethinylestriol, and is a more potent estrogen in comparison, but, in contrast to ethinylestriol, has been marketed. Ethinylestriol has been found to reduce the risk of 7,12-dimethylbenz(a)anthracene (DMBA)-induced mammary cancer when given as a prophylactic in animal models, while other estrogens like ethinylestradiol and diethylstilbestrol were ineffective.

Women with menopause have often been given various types of postmenopausal hormone therapies to prevent osteoporosis and reduce menopausal symptoms. Medroxyprogesterone acetate (MPA) is a synthetic progestin and was commonly used as a contraceptive or used as a hormone therapy for endometriosis or osteoporosis. Recent studies suggest, using MPA increases patient risks of developing breast cancer due to an increase expression of RANKL. MPA causes a substantial induction of RANKL in mammary-gland epithelial cells while deletion of RANKL decreases the incidence MPA-induced breast cancer.

MDA-MB-468 is a cell line that was isolated from a 51-year-old female human in 1977, and is commonly used in breast cancer research. MDA-MB-468 cells were extracted from a pleural effusion of mammary gland and breast tissues, and have proven useful for the study of metastasis, migration, and breast cancer proliferation. The cell line was isolated in 1977 by R. Cailleau, et al., from a pleural effusion of a 51-year-old Black female patient with metastatic adenocarcinoma of the breast.

The cows teat is a projection of the mammary gland that is sealed during their dry period.A dry cow refers to a dairy cow that is in a stage of their lactation cycle where milk production ceases prior to calving. This part of their lactation cycle is referred to as the cows dry period and typically last between 40 and 65 days. Dry cows are typically divided into two groups: far- off (60–21 days before calving) and close-up (21 days to calving).

Mammary Lane is a listener request show featuring clips of The Howard Stern Show. The show airs on Howard 100 and Howard 101 on SIRIUS XM Radio, during certain weeks when the Stern Show is on vacation. The hosts of the show rotate and have included Richard Christy, Sal "The Stockbroker" Governale, Jason Kaplan, Will Murray, Gary Dell'Abate, and Jon Hein. The show is a production of "The Tapes Team" at SIRIUS, along with Master Tape Theatre, Stern Spotlight, The History of Howard Stern and Road Trip.

In F. U. Reuss and J. M. Coffin (2000) experiments it is mentioned that the expression of the virus genome is activated by an enhancer element that is present in the U3 region of the long terminal repeat of the genome. In addition the expression of the genome is activated specifically in the mammary gland cells. Estrogen is able to further activate the expression of the viral genome. The expression of sag gene which is present in the provirus is responsible for the production of a superantigen.

The ER activity can be monitored using immunohistochemical methods in applications like tissue analysis for tumorgenesis. The activation of the ER through binding to the estrogen hormone stimulates the mammary cell division, catalyzing the cell division and DNA replication process. This results in exponential multiplication of replications of the mutated genes, along with large amounts of genotoxic waste in response to this estrogen metabolism pathway. These ill effects highly increase the chances of malignant cell formation, and in turn, increases the chance of tumor formation.

Coronary artery bypass surgery, also known as coronary artery bypass graft (CABG, pronounced "cabbage") surgery, and colloquially heart bypass or bypass surgery, is a surgical procedure to restore normal blood flow to an obstructed coronary artery. A normal coronary artery transports blood to the heart muscle itself, not through the main circulatory system. There are two main approaches. In one, the left internal thoracic artery, LITA (also called left internal mammary artery, LIMA) is diverted to the left anterior descending branch of the left coronary artery.

TMEM217 is not ubiquitously expressed. The gene tends to have expression correlated to lymphatic system, vascular/arterial endothelial tissue, and notable expression in the bladder based on expression profiles and microarray analysis. Other tissues that have been shown to express TMEM217 include: connective tissues, the liver, mammary glands, the testis, and the cervix. Co-expression analyses have found that TMEM217 was up-regulated in response to mechanical stretch in dermal fibroblast cells and in response to the resveratrol derivative, DMU-212, in vascular endothelial tissues.

The gene is flanked by UBR4 on its right and MRTO4 on its left. This Information is graphically displayed in Figure 1. Expressed Sequence Tags and isolated cDNA clones indicate KIAA0090 is expressed ubiquitously in low to moderate levels throughout the body. This includes but is not limited to testis, tongue, lung, cerebellum, brain, mammary gland, trachea, placenta, esophageal, salivary gland, brain, hippocampus, amygdale, bone marrow, thalamus, spleen, uterus, thymus, kidney, eye, heart, gall bladder, prostate, liver, parathyroid gland, ovary, stomach, skeletal muscle, colon, pancreas, and skin.

BT-20 is a breast cancer cell line derived from a 74-year-old human female in 1958 by E.Y. Lasfargues and L. Ozzello. The cells technically came from a triple-negative breast cancer, which was caused by an invasive ductal carcinoma in the mammary gland. BT-20 cells are known to have amplified regions of chromosomes 6, 11, and 20, with most cells being hyperdiploid. The cells express an estrogen receptor with a deletion of exon 5, and are used in preclinical studies of breast cancer.

The signaling activation of SHC is implicated in tumorigenic in cancer cells there is a potential to use SHC as a prognostic marker when targeting cancer treatment. SHC1 interacts with SgK269 which is a member of the Src kinase signaling network that characterized basal breast cancer cells. When SgK269 is overexpressed in mammary epithelial cells it promotes the cell growth and might contribute to the progression of aggressive breast cancers. In prostate and ovarian cancer, increased expression of p66Shc appears to promote cell proliferation.

Subsequent studies suggest that the protein may cross-react with a monoclonal antibody that recognizes the phosphatidylserine receptor and does not directly function in the clearance of apoptotic cells. Multiple transcript variants encoding different isoforms have been found for this gene. On a physiological level JMJD6 has a role in angiogenesis, the process of vessel formation, whereas further roles of JMJD6 in pathophysiological processes were implicated, such as mammary tumorigenesis. Here, elevated JMJD6 level were found in breast cancer associated with aggressiveness and metastasis in mice.

Genetic loss or systemic knockdown of Malat1 using antisense oligonucleotides (ASO) in the mouse mammary carcinoma model results in slower tumor growth accompanied by significant differentiation into cystic tumors and a reduction in metastasis. At the molecular level, the ASO-Malat1 hybrid stimulates a naturally occurring cellular enzyme that degrades the Malat1 lncRNA. Malat1 knockdown results in alterations in gene expression and changes in splicing patterns of genes involved in differentiation and protumorigenic signaling pathways. Metastatic tumors have a dependency on Malat1—they can't thrive without it.

The ER- positive tumors were characterized by high expression of genes normally expressed in breast luminal cells. The authors suggest that this higher-order distinction may encompass at least two biologically distinct types of cancer that may each require a unique course of treatment. Within the ER-negative group, additional clusters were identified based on expression of Erb-B2 and keratin 5- and 17-enriched basal epithelial-like genes. These groups reflect distinct molecular features as related to mammary epithelial biology, based on the outcome of disease.

During the early parts of Lynch’s career, the field of cancer research was growing rapidly, and may scientists were making huge advancements in the understanding of this disease. She joined this field when she began her work as a faculty member at the Rockefeller Institute for Medical Research under James B. Murphy. Lynch was one of the first female scientists to study cancer. In the beginning, she studied mammary tumors in mice noting that some mice formed tumors more rapidly and spontaneously than others.

Staging, Breastcancer.org It rarely produces symptoms or a breast lump one can feel, typically being detected through screening mammography. In DCIS, abnormal cells are found in the lining of one or more milk ducts in the breast. In situ means "in place" and refers to the fact that the abnormal cells have not moved out of the mammary duct and into any of the surrounding tissues in the breast ("pre-cancerous" refers to the fact that it has not yet become an invasive cancer).

From 1925 to 1933, he was a professor at the University of Cologne, where he was instrumental in the founding of its institute of zoology. In 1934 he returned to Brazil as director of the zoological institute at the University of São Paulo.Bresslau, Ernst Ludwig NDB/ADB Deutsche Biographie His primary areas of research involved the evolutionary development of flatworms, investigations of infusoria and the development of mammary organs in marsupials.Contributions from the Department of Anatomy, Volumes 5-6 by the University of Minnesota.

There will be significant tension on the scar line, and to prevent spreading of the scar, a permanent fixation suture is needed. Leaving outer dermis (raw skin) underneath the marginalized areola helps in its survival. The keyhole incision (think skeleton key) augments the periareolar incision further by making a vertical closure underneath (lollipop), which results after the unwanted skin is pulled in from side to side and the excess is removed. An anchor incision adds to that a transverse incision usually in the infra mammary fold to further remove excessive skin.

CUBIC (abbreviation for “clear, unobstructed brain imaging cocktails and computational analysis) is a histology method that allows tissues to be transparent (process called “tissue clearing”). As a result it makes investigation of large biological samples with microscopy easier and faster. The method was published in 2014 by Etsuo A. Susaki and Hiroki R. Ueda, primarily for use in neurobiology research of brains from model organisms like rodents or small primates. But in upcoming years there were other works published, using CUBIC method on other tissues like lymph nodes or mammary glands.

Various raw meats Animals are used as food either directly or indirectly by the products they produce. Meat is an example of a direct product taken from an animal, which comes from muscle systems or from organs (offal). Food products produced by animals include milk produced by mammary glands, which in many cultures is drunk or processed into dairy products (cheese, butter, etc.). In addition, birds and other animals lay eggs, which are often eaten, and bees produce honey, a reduced nectar from flowers, which is a popular sweetener in many cultures.

Mammals (from Latin mamma "breast") are a group of vertebrate animals constituting the class Mammalia (), and characterized by the presence of mammary glands which in females produce milk for feeding (nursing) their young, a neocortex (a region of the brain), fur or hair, and three middle ear bones. These characteristics distinguish them from reptiles and birds, from which they diverged in the late Carboniferous, approximately 300 million years ago. Around 6,400 extant species of mammals have been described. The largest orders are the rodents, bats and Eulipotyphla (hedgehogs, moles, shrews, and others).

4,4'-Methylenebis(2-chloroaniline) (also known as MOCA, MBOCA, and bisamine) is a substance used as a curing agent in polyurethane production.RTK HSFS 1250 MOCA is an aromatic amine which is structurally similar to benzidine, a known human bladder carcinogen. MOCA has been shown to cause hepatomas in mice and rats, lung and mammary carcinomas in rats and bladder cancer in dogs. It is a proven human carcinogen standing on the WHO List of IARC Group 1 carcinogens, with a current threshold limit value of 0.01 ppm in the industrial atmosphere.

Further work on dog kidney cells has shown that a signaling cascade involving the phosphorylation of EGFR by Yes leading to the activation of Rab11FIP5 by MAPK1 upregulates transcytosis. Transcytosis has been shown to be inhibited by the combination of progesterone and estradiol followed by activation mediated by prolactin in the rabbit mammary gland during pregnancy. In the thyroid, follicular cell transcytosis is regulated positively by TSH . The phosphorylation of caveolin 1 induced by hydrogen peroxide has been shown to be critical to the activation of transcytosis in pulmonary vascular tissue.

Galactography may be used to investigate the condition of the mammary duct system before the intervention. Pre-operatively, also breast ultrasound and mammogram are performed to rule out other abnormalities of the breast. If the condition involves only a single duct, then microdochectomy may be indicated, in particular in women wishing to preserve the ability to breastfeed; if the condition involves from several ducts or if no specific duct could be determined, then a subareolar resection of the ducts (central duct excision, also called Hadfield's procedure) may be indicated instead.

The primary transmission route is the litter box that is shared by both infected and uninfected cats, where a well-timed use by two cats can transfer the parasite from the feces of one cat to the paws of another where they later become ingested during the act of grooming. In cats, Tritrichomonas foetus is able to live several days in wet stool. Mutual grooming may also transfer the parasite. There is no evidence that T. foetus is sexually transmitted or infects the reproductive tract or mammary glands of cats.

Sulf2 also was implicated in breast cancer. In contrast to Sulf1, Sulf2 was upregulated at both the mRNA and protein levels in tumor tissue in two mammary carcinoma mouse models. Sulf1 displays regulation of amphiregulin and HB-EGF-mediated autocrine and paracrine signaling in breast cancer. Loss of Sulf1 in a breast cancer cell line, MDA-MB-468, shows increased ERK1/2 and EGFR activation, which was shown to be mediated by HB-EGF and amphiregulin, which require complexes with specifically sulfated HS. Breast cancer samples show loss of Sulf1 expression in invasive lobular carcinomas.

Receptor activator of nuclear factor κ B (RANK), also known as TRANCE receptor or TNFRSF11A, is a member of the tumor necrosis factor receptor (TNFR) molecular sub-family. RANK is the receptor for RANK-Ligand (RANKL) and part of the RANK/RANKL/OPG signaling pathway that regulates osteoclast differentiation and activation. It is associated with bone remodeling and repair, immune cell function, lymph node development, thermal regulation, and mammary gland development. Osteoprotegerin (OPG) is a decoy receptor for RANKL, and regulates the stimulation of the RANK signaling pathway by competing for RANKL.

The cytoplasmic domain of RANK binds TRAFs 1, 2, 3, 5, and 6 which transmit signals to downstream targets such as NF-κB and JNK. RANK is constitutively expressed in skeletal muscle, thymus, liver, colon, small intestine, adrenal gland, osteoclast, mammary gland epithelial cells, prostate, vascular cell, and pancreas. Most commonly, activation of NF-κB is mediated by RANKL, but over-expression of RANK alone is sufficient to activate the NF-κB pathway. RANKL (receptor activator for nuclear factor κ B ligand) is found on the surface of stromal cells, osteoblasts, and T cells.

A second French edition was published in 1835 with the title Traité complet de l'art des accouchements, etc.Pagel: Biographical Dictionary outstanding physicians of the nineteenth century. Berlin, Vienna, 1901, 1758-1761 Sp. Other works by Velpeau that have been translated into English are: Nouveaux éléments de médecine opératoire (1832) as "New elements of operative surgery" (1856) and Traité des maladies du sein et de la région mammaire as "A treatise on the diseases of the breast and mammary region" (1856).WorldCat Identities (publications) He is credited with providing the first accurate description of leukemia (1827).

Using the EST abundance profile through Unigene, NBEAL1 expression was discovered based on both body sites and health states. NBEAL1 shows expression in the brain, embryonic tissue, eye, intestine, kidney, liver, lung, mammary glands, ovaries, pancreas, pharynx, placenta, prostate, skin, stomach, testis, thyroid, and trachea. Based on transcripts per million, expression is highest in the stomach at 62 transcripts per million, with pancreas and trachea being next with their transcripts per million being 37 and 38, respectively. The lowest transcripts per million in the brain, eye, placenta and testis, all at 4 per million.

In the 15th, 16th and 17th centuries, it became acceptable for doctors to dissect bodies to discover the cause of death. The German professor Wilhelm Fabry believed that breast cancer was caused by a milk clot in a mammary duct. The Dutch professor Francois de la Boe Sylvius, a follower of Descartes, believed that all disease was the outcome of chemical processes and that acidic lymph fluid was the cause of cancer. His contemporary Nicolaes Tulp believed that cancer was a poison that slowly spreads and concluded that it was contagious.

Increases in lymphomas were seen in mice and increases in adenocarcinomas of the small and large intestine in males and mammary adenocarcinomas in female were seen in rats. Also, an increasing number of epidemiological studies have evaluated the association of well-done meat intake and HCA exposure with cancer risk in humans. In general, these studies have reported that high intake of well-done and/or high exposure to PhIP may be associated with cancer of the colorectum, breast, prostate, pancreas, lung, stomach, and esophagus.Zheng, W. & Lee, S. (2009).

For example, shoveling and double-shoveling of upper first incisors and the presence of hypoconulids of lower second molars have been found to be linked to the ectodysplasin A receptor gene (EDAR). EDAR is a functional genomic region and has a range of pleiotropic effects on ectodermally derived structures, such as hair, mammary glands, and teeth, and is most likely under positive selection in Asian populations. It is possible that dental variants linked to EDAR are not direct targets of positive selection but rather 'hitchhiking' when selection acts on another phenotype.

Female characteristics vary between different species with some species containing more well defined female characteristics, such as the presence of pronounced mammary glands. There is no single genetic mechanism behind sex differences in different species and the existence of two sexes seems to have evolved multiple times independently in different evolutionary lineages. The word female comes from the Latin femella, the diminutive form of femina, meaning "woman";Charlton T. Lewis, Charles Short, A Latin Dictionary - fēmella, ae, f. dim. femina Retrieved 2019-11-24 it is not etymologically related to the word male.

Instead of just recording the change in heat generated by the tumor, the image is now able to identify changes due to the vascularization of the mammary gland. In order for a tumor (to originate, develop and grow) an enhanced blood supply is necessary (angiogenesis theory). The more detailed map of the vascular network contains information pointing to the location where the breast has changed to accommodate the tumor. More importantly, the ability to visualize tumors in a precancerous state enables prompt and strategic removal, which of course removes the cause of the tumor.

In their The Japanese Film: Art and Industry, Anderson and Richie described Maeda as "a star who consisted almost entirely of mammary glands." Shintoho took advantage of Maeda's popularity to cast her in more roles in which she could display her famous figure. Other film studios reportedly engaged in a nationwide search to discover their own buxom models to compete with Maeda. Later in 1956, she was given the starring role in , a melodramatic thriller set on an isolated island about a woman seeking revenge for her dead lover.

Each adult breast consists of 15 to 20 milk-producing mammary glands, irregularly shaped lobes that include alveolar glands and a lactiferous duct leading to the nipple. The lobes are separated by dense connective tissues that support the glands and attach them to the tissues on the underlying pectoral muscles. Other connective tissue, which forms dense strands called suspensory ligaments, extends inward from the skin of the breast to the pectoral tissue to support the weight of the breast. Heredity and the quantity of fatty tissue determine the size of the breasts.

NMU Substance Profile NTP, Report on Carcinogens, Eleventh Edition Various cancers induced in animal models include: squamous cell carcinomas of the forestomach, sarcomas and gliomas of the brain, adenocarcinomas of the pancreas, mammary carcinomas, leukemia, and lymphomas. However, the actual potential for human exposure is quite limited, as the chemical is not produced or used in large quantities NMU is teratogenic and embryotoxic, resulting in craniofacial (cleft palate) and skeletal defects, fetal growth retardation, and increased fetal resorption.Wada, A., et al. (1994). Induction of Congenital Malformations in Mice by Paternal Methylnitrosourea Treatment.

ERα plays a role in the physiological development and function of a variety of organ systems to varying degrees, including the reproductive, central nervous, skeletal, and cardiovascular systems. Accordingly, ERα is widely expressed throughout the body, including the uterus and ovary, male reproductive organs, mammary gland, bone, heart, hypothalamus, pituitary gland, liver, lung, kidney, spleen, and adipose tissue. The development and function of these tissues is disrupted in animal models lacking active ERα genes, such as the ERα knockout mouse (ERKO), providing a preliminary understanding of ERα function at specific target organs.

EIS can be experimentally induced in animals via knockout of the ER. In these so-called ERKO mice, different ERs can be disabled allowing to study the role of these receptors. ERKO mice show development of the respective female or male reproductive systems, and male and female αERKO mice are infertile, βERKO males are fertile while females are subfertile, male and female double αERKO and βERKO mice are infertile. The uterus and mammary glands are hypoplastic and do not respond to exogenous stimulation by estrogens. Males are infertile with atrophy in the testes.

This treatment is purely cosmetic and does not make up for the patient's imbalanced upper body strength. The Poland syndrome malformations being morphological, correction by custom implant is a first-line treatment. This technique allows a wide variety of patients to be treated with good outcomes. Poland Syndrome can be associated with bones, subcutaneous and mammary atrophy: if the first, as for pectus excavatum, is successfully corrected by a custom implant, the others can require surgical intervention such as lipofilling or silicone breast implant, in a second operation.

Mouse mammary tumor virus (MMTV) is a milk-transmitted retrovirus like the HTL viruses, HI viruses, and BLV. It belongs to the genus Betaretrovirus. MMTV was formerly known as Bittner virus, and previously the "milk factor", referring to the extra-chromosomal vertical transmission of murine breast cancer by adoptive nursing, demonstrated in 1936, by John Joseph Bittner while working at the Jackson Laboratory in Bar Harbor, Maine. Bittner established the theory that a cancerous agent, or "milk factor", could be transmitted by cancerous mothers to young mice from a virus in their mother's milk.

The American Dialect Society had a number of related terms for word of the year nominations in 2004, including Janet moment ("unplanned bodily exposure at a public function"), boobgate ("scandal over Janet Jackson's exposed breast"), nipplegate (like boobgate, "but used earlier in squawk over Jackson's possible nipple ring"), and wardrobe malfunction ("overexposure in a mammary way"). The term has been translated into other languages to describe similar incidents, including garderobedefect (Dutch), incident de garde-robe (French), disfunzione del guardaroba or incidente del guardaroba (Italian), and mal funcionamiento de vestuario (Spanish).

TMEM171 is moderately and differentially expressed, indicating that it is neither a housekeeping gene nor a tissue-enriched gene. Its expression is highest in the thyroid, mammary gland, stomach, duodenum, and kidney. It is also expressed at moderate levels in tissues including the spleen, ileum, colon, salivary gland, and expressed at lower levels in a variety of other tissues. Conditional expression patterns of TMEM171 include decreased expression in papillary thyroid carcinoma, colon cancer, and gastric cancer, as well as increased expression in p63-depleted tissue and induced alveolar macrophages.

Milk is composed of my bioconstituents, but only a few will be outlined here. In the first days of puerperium, the first milk is thick and yellowish, also called colostrum. For weeks after that, mature milk is expressed and it has been shown that fetal-mammary gland signaling occurs even before birth in determining milk type and concentrations based on the fetus sex. Colostrum plays an important role in establishing the infant gut microbiome, as it contains important immunoglobins, and is high in protein and low in fat and milk sugar such as lactose.

The episode begins with Jeff and Lester reviewing footage they shot of women's cleavage with one of the store's demo cameras when Chuck arrives to remind them of Big Mike's warning about "Mammary Cam." The two Nerd Herders protest the accusation, but while chewing them out, Chuck is confronted by Devon who wants to ask him a question. Chuck discovers a bug hidden on one of the Nerd Herd's displays and flashes. He has to dodge Devon for a moment to confront Casey, who he believes had placed the bug.

Being mammals, they have mammary glands used for nursing calves; they are weaned around 11 months of age. This milk contains high amounts of fat which is meant to hasten the development of blubber; it contains so much fat, it has the consistency of toothpaste. Females deliver a single calf, with gestation lasting about a year, dependency until one to two years, and maturity around seven to 10 years, all varying between the species. This mode of reproduction produces few offspring, but increases the survival probability of each one.

Depending on a drug's functional groups, it may be metabolized in similar or different ways between species, which will affect both efficacy and toxicology. Medical device studies also use this basic premise. Most studies are performed in larger species such as dogs, pigs and sheep which allow for testing in a similar sized model as that of a human. In addition, some species are used for similarity in specific organs or organ system physiology (swine for dermatological and coronary stent studies; goats for mammary implant studies; dogs for gastric and cancer studies; etc.).

Minor lymphocyte stimulating (Mls) exotoxins were originally discovered in the thymic stromal cells of mice. These toxins are encoded by SAg genes that were incorporated into the mouse genome from the mouse mammary tumour virus (MMTV). The presence of these genes in the mouse genome allows the mouse to express the antigen in the thymus as a means of negatively selecting for lymphocytes with a variable Beta region that is susceptible to stimulation by the viral SAg. The result is that these mice are immune to infection by the virus later in life.

The pelycosaur scutes probably were nonoverlapping dermal structures with a horny overlay, like those found in modern crocodiles and turtles. These differed in structure from the scales of lizards and snakes, which are an epidermal feature (like mammalian hair or avian feathers). Recently, skin impressions from the genus Ascendonanus suggest that at least varanopsids developed scales similar to those of squamates. It is currently unknown exactly when mammalian characteristics such as body hair and mammary glands first appeared, as the fossils only rarely provide direct evidence for soft tissues.

The major tissues affected by progestogens include the uterus, vagina, cervix, breasts, testes, and brain. The main biological role of progestogens in the body is in the female reproductive system, and the male reproductive system, with involvement in regulation of the menstrual cycle, maintenance of pregnancy, and preparation of the mammary glands for lactation and breastfeeding following parturition in women; in men progesterone affects spermiogenesis, sperm capacitation, and testosterone synthesis. Progestogens also have effects in other parts of the body. Unlike estrogens, progestogens have little or no role in feminization.

Their ears are normally longer than they are wide, with a long and lance-shaped tragus, hence their English and zoological names (in Greek, myotis and myosotis mean "mouse-ear"). The species within this genus vary in size from very large to very small for vesper bats, with a single pair of mammary glands. Mouse-eared bats are generally insectivores. M. vivesi, and several members of the trawling bat ecomorph Leuconoe, have relatively large feet with long toes, and take small fish from the water surface (they also take insects).

Oncogenic retroviridae proteins are retroviral proteins that have the ability to transform cells. They can induce sarcomas, leukaemias, lymphomas, and mammary carcinomas. These include the gag-onc fusion protein, rex, tax, v-fms, ras, v-myc, v-src, v-akt, v-cbl, v-crk, v-maf, v-abl, v-erbA, v-erbB, v-fos, v-mos, v-myb, v-raf, v-rel, and v-sis. The "v" prefix indicates viral genes which once originated as similarly named genes of the host species, but have since been altered through independent evolution as retroviral components.

Similar to breast tumors, the role of GATA3 in the genesis of other tumor types is unclear but detection of its transcription factor product may be diagnostically useful. Immuocytochemical analysis of GATA3 protein is considered a valuable marker for certain types of urinary bladder and urethral cancers as well as for parathyroid gland tumors (cancerous or benign), Single series reports suggest that this analysis might also be of value for diagnosing salivary gland tumors, salivary duct carcinomas, mammary analog secretory carcinomas, benign ovarian Brenner tumors, benign Walthard cell rests, and paragangliomas.

The corpus luteum persists as if the queen were pregnant because the queen's body cannot distinguish between the pregnant and non-pregnant state (aside from the initial mechanical trigger of coitus). Pseudopregnant queens rarely show any mammary enlargement or behavioral signs and therefore rarely require treatment. Pseudopregnancy in cats is uncommon as the queen must be bred by an infertile male to become pseudopregnant, compounded by the fact that cats are seasonal breeders. The progesterone and estradiol profiles in pseudopregnancy are very different when compared to normal pregnancy.

Figure 3: The domain structures of ERα and ERβ, including some of the known phosphorylation sites involved in ligand-independent regulation. SERM act on the estrogen receptor (ER), which is an intracellular, ligand-dependent transcriptional activator and belongs to the nuclear receptor family. Two different subtypes of ER have been identified, ERα and ERβ. ERα is considered the main medium where estrogen signals are transduced at the transcriptional level and is the predominant ER in the female reproductive tract and mammary glands while ERβ is primarily in vascular endothelial cells, bone, and male prostate tissue.

These drugs inhibit NTRK3's tyrosine kinase activity. Crizotinib has proven useful in treating certain cases of acute lymphoblastic leukemia that are associated with the ETV6-NTRK3 fusion gene while larotrectinib and entrectinib have been useful in treating various cancers (e.g. a metastatic sarcoma, papillary thyroid cancer, non-small-cell lung carcinoma, gastrointestinal stromal tumor, mammary analog secretory carcinoma, and colorectal cancer) that are driven by mutated, overly active tyrosine kinases. Relevant to this issue, a 16-month-old girl with infantile fibrosarcoma harboring the ETV6–NTRK3 fusion gene was successfully treated with larotrectinib.

Humans are not the only mammals susceptible to breast cancer. Some strains of mice, namely the house mouse (Mus domesticus) are prone to breast cancer which is caused by infection with the mouse mammary tumour virus (MMTV or "Bittner virus" for its discoverer John Joseph Bittner), by random insertional mutagenesis. It is the only animal breast cancer with a known etiology. These findings are taken to mean that a viral origin of human breast cancer is at least possible, though there is no definitive evidence to support the claim that MMTV causes human breast cancer.

Xed: An alien hatched at mammary central just like his 27 brothers and 15 sisters. From an early age, Xed was bad tempered and had an aversion to machines. As soon as he was of age, Xed was put into the newly formed terraforming service where he could focus his destructive energies to the benefit of the common good. Xed quickly gained a reputation of being a loner and could always be found terraforming away from the others, and in particular the machines run by the Terracon brain.

The role of iodine in mammary tissue is related to fetal and neonatal development, but its role in the other tissues is not well known. It has been shown to act as an antioxidant and antiproliferant in various tissues that can uptake iodine. Molecular iodine (I2) has been shown to have a suppressive effect on benign and cancerous neoplasias. The U.S. Food and Nutrition Board and Institute of Medicine recommended daily allowance of iodine ranges from 150 micrograms per day for adult humans to 290 micrograms per day for lactating mothers.

A study found full lobuloalveolar maturation of the mammary glands on histological examination in transgender women treated with an estrogen and high-dose cyproterone acetate. However, lobuloalveolar development reversed with discontinuation of cyproterone acetate, indicating that continued progestogen exposure is necessary to maintain the tissue. In terms of the effects of progestogens on sex drive, one study assessed the use of dydrogesterone to improve sexual desire in transgender women and found no benefit. Another study likewise found that oral progesterone did not improve sexual function in cisgender women.

Being mammals, they have mammary glands used for nursing calves; they are weaned off at about 11 months of age. This milk contains high amounts of fat which is meant to hasten the development of blubber; it contains so much fat that it has the consistency of toothpaste. Females deliver a single calf with gestation lasting about a year, dependency until one to two years, and maturity around seven to ten years, all varying between the species. This mode of reproduction produces few offspring, but increases the survival probability of each one.

In mammals, transketolase connects the pentose phosphate pathway to glycolysis, feeding excess sugar phosphates into the main carbohydrate metabolic pathways. Its presence is necessary for the production of NADPH, especially in tissues actively engaged in biosyntheses, such as fatty acid synthesis by the liver and mammary glands, and for steroid synthesis by the liver and adrenal glands. Thiamine diphosphate is an essential cofactor, along with calcium. Transketolase is abundantly expressed in the mammalian cornea by the stromal keratocytes and epithelial cells and is reputed to be one of the corneal crystallins.

Known flavivirus vector-borne viruses include Dengue virus, Yellow Fever virus, tick-borne encephalitis virus, and West Nile virus. In 1958, MODV was first isolated from the mammary gland tissue of a white-footed deer mouse (Peromyscus maniculatus) captured in Modoc County, California. Since the first isolation, the MODV has also been isolated from deer mice in Oregon, Colorado, and Montana. There are other anti-genetically and genetically related viruses which also have no known vector such as Jutiapa virus, the Cowbone Ridge virus, the Sal Vieja virus, and the San Perlita virus.

As a mammary gland, the breast is composed of differing layers of tissue, predominantly two types: adipose tissue; and glandular tissue, which affects the lactation functions of the breasts. Morphologically the breast is tear-shaped. The superficial tissue layer (superficial fascia) is separated from the skin by 0.5–2.5 cm of subcutaneous fat (adipose tissue). The suspensory Cooper's ligaments are fibrous-tissue prolongations that radiate from the superficial fascia to the skin envelope. The female adult breast contains 14–18 irregular lactiferous lobes that converge at the nipple.

Breast development in puberty is measured with the five-stage Tanner Scale The morphological structure of the human breast is identical in males and females until puberty. For pubescent girls in thelarche (the breast-development stage), the female sex hormones (principally estrogens) in conjunction with growth hormone promote the sprouting, growth, and development of the breasts. During this time, the mammary glands grow in size and volume and begin resting on the chest. These development stages of secondary sex characteristics (breasts, pubic hair, etc.) are illustrated in the five-stage Tanner Scale.

All three isoforms of the deiodinases are selenium-containing enzymes; thus dietary selenium is essential for T3 production. Iodine accounts for 65% of the molecular weight of T4 and 59% of T3. Fifteen to 20 mg of iodine is concentrated in thyroid tissue and hormones, but 70% of all iodine in the body is found in other tissues, including mammary glands, eyes, gastric mucosa, fetal thymus, cerebro-spinal fluid and choroid plexus, arterial walls, the cervix, and salivary glands. In the cells of those tissues, iodide enters directly by sodium-iodide symporter (NIS).

Spironolactone has weak progestogenic activity in bioassays. Its actions in this regard are a result of direct agonist activity at the PR, though with a very low half-maximal potency. Spironolactone's progestogenic activity has been suggested to be involved in some of its side effects, including the menstrual irregularities seen in women and the undesirable serum lipid profile changes that are seen at higher doses. It has also been suggested to augment the gynecomastia caused by the estrogenic effects of spironolactone, as progesterone is known to be involved in mammary gland development.

LGP2 was first identified and characterized in the context of mammary tissue in 2001, but its function has been found to be more relevant to the field of innate antiviral immunity. LGP2 has been found to be essential for producing effective antiviral responses against many viruses that are recognized by RIG-I and MDA5. Since LGP2 lacks CARD domains, its effect on downstream antiviral signaling is likely due to interaction with dsRNA viral ligand or the other RLRs (RIG-I and MDA5). LGP2 has been shown to directly interact with RIG-I through its C-terminal repressor domain (RD).

Reproductive system of a bovine female Ox testes On farms it is very common to use artificial insemination (AI), a medically assisted reproduction technique consisting of the artificial deposition of semen in the female's genital tract. It is used in cases where the spermatozoa can not reach the fallopian tubes or simply by choice of the owner of the animal. It consists of transferring, to the uterine cavity, spermatozoa previously collected and processed, with the selection of morphologically more normal and mobile spermatozoa. A cow's udder contains two pairs of mammary glands, (commonly referred to as teats) creating four "quarters".

Bioluminescence imaging relies on the detection of light produced by the enzymatic oxidation of an exogenous substrate. The substrate luciferin, is oxidized to oxyluciferin in the presence of luciferase and emits light, which can be detected using an IVIS system such as a Xenogen machine. Dissociated mammary cells from MMTV-PyMT: IRES: Luc; MTB (Internal ribosome entry site: Luciferin) animals (which were not exposed to doxycycline) can be injected into the lateral tail veins of immunodeficient mice on a doxycycline- free diet. No bioluminescence signal will be observed in the lungs of recipient mice until they are given doxycycline food.

Breast cancer is consensually considered genetically and clinically as a heterogeneous disease, in that it reflects the heterogeneity of the normal breast tissue at its origin17873350. A number of discrete genetic events have to occur in order to enable individual tumor cells that have the capacity to grow at an ectopic site. The metastatic progression depends on the regulation of developmental programs and environmental events. The metastatic potential of sub populations within mouse mammary cells is now considered as relatively an early event and dissemination occurs at the same time of pre invasive or micro-invasive lesions.

His research using a stem cell model system suggested that a single malignant cell with stem cell properties may be sufficient to induce cancer in mice and can generate distinct populations of tumor- initiating cells also with cancer stem cell properties. Dulbecco's examinations into the origin of mammary gland cancer stem cells in solid tumors was a continuation of his early investigations of cancer being a disease of acquired mutations. His interest in cancer stem cells was strongly influenced by evidence that in addition to genomic mutations, epigenetic modification of a cell may contribute to the development or progression of cancer.

The five surgical approaches to emplacing a breast implant to the implant pocket are often described in anatomical relation to the pectoralis major muscle. # Subglandular: the breast implant is emplaced to the retromammary space, between the breast tissue (the mammary gland) and the pectoralis major muscle (major muscle of the chest), which most approximates the plane of normal breast tissue, and affords the most aesthetic results. Yet, in women with thin pectoral soft-tissue, the subglandular position is likelier to show the ripples and wrinkles of the underlying implant. Moreover, the capsular contracture incidence rate is slightly greater with subglandular implantation.

A 2016 Cochrane review found that skin-to-skin contact at birth promotes the likelihood and effectiveness of breastfeeding. As of 2014, early postpartum skin-to-skin contact is endorsed by all major organizations that are responsible for the well-being of infants, including the American Academy of Pediatrics. The World Health Organization (WHO) states that "the process of childbirth is not finished until the baby has safely transferred from placental to mammary nutrition." They advise that the newborn be placed skin-to-skin with the mother, postponing any routine procedures for at least one to two hours.

Scientists speculated that Dolly's death in 2003 was related to the shortening of telomeres, DNA-protein complexes that protect the end of linear chromosomes. However, other researchers, including Ian Wilmut who led the team that successfully cloned Dolly, argue that Dolly's early death due to respiratory infection was unrelated to problems with the cloning process. This idea that the nuclei have not irreversibly aged was shown in 2013 to be true for mice. Dolly was named after performer Dolly Parton because the cells cloned to make her were from a mammary gland cell, and Parton is known for her ample cleavage.BBC.

Campbell's interest in cloning mammals was inspired by work done by Karl Illmensee and John Gurdon. Working at the Roslin Institute since 1991, Campbell became involved with the cloning efforts led by Ian Wilmut. In July 1995 Keith Campbell and Bill Ritchie succeeded in producing a pair of lambs, Megan and Morag from embryonic cells, which had differentiated in culture. Then, in 1996, a team led by Ian Wilmut with Keith Campbell as the main (66% of the credit) contributor used the same technique and shocked the world by successfully cloning a sheep from adult mammary cells.

Profile of a typical ruffed lemur overbite Ruffed lemurs are the largest extant members of the family Lemuridae, with an average head-body length between and a total length from , while ranging in weight from . The thick, furry tail is longer than the body, averaging in length and is used primarily for balance while moving through the trees. Ruffed lemurs exhibit neither sexual dimorphism nor sexual dichromatism, and females have three pairs of mammary glands. Foot of a ruffed lemur, showing the toilet-claw on the second toe Ruffed lemurs are characterized by their long, canine-like muzzle, which includes a significant overbite.

However, by 15 weeks, ductal development has caught up with that of normal mice and the ducts have fully distributed throughout the mammary fat pad, although the ducts remain narrower than those of wild-type mice. In any case, female GHR knockout mice can lactate normally. As such, it has been said that the phenotypes of women with Laron syndrome and GHR knockout mice are identical, with diminished body size and delayed sexual maturation accompanied by normal lactation. These data indicate that very low circulating levels of IGF-1 can nonetheless allow for full pubertal breast development.

Variation in modern human incisor shoveling has been associated with the presence/absence of the V370A allele of the Ectodysplasin A Receptor (EDAR) gene. The EDAR V370A isoform arises from a single nucleotide polymorphism/missense mutation which changes the 370 Valine residue to an Alanine on the EDAR gene. The effect is approximately additive, where individuals with one copy of the allele have intermediate expression of shovel-shaped incisors and homozygotes have more strongly shoveled incisors. The trait is pleiotropically related to thicker and straighter hair shafts, other dental traits, sweat glands, and mammary gland ductal branching.

Conversely, the progesterone-like effects of amphenone B on the mammary glands were found to persist even in adrenalectomized and ovariectomized animals. Amphenone B was tested in humans in the mid-1950s as a potential treatment for cortisol-dependent conditions such as Cushing's syndrome and adrenocortical carcinoma. In healthy subjects and patients with adrenocortical carcinoma, the drug was found to be effective in decreasing circulating levels of corticosteroids including cortisol, corticosterone, and aldosterone, as well as in decreasing circulating levels of androgens and estrogens. Moreover, due to reduced aldosterone secretion, it caused marked diuresis and increased urinary sodium excretion.

Consequently, there is profound overdosage of progestogenic effect (and by extension progestogenic side effects) when CPA is used as an antiandrogen at high doses. For this reason, it has been said that CPA cannot be considered an ideal antiandrogen. Through its action as a progestogen, CPA has been found to significantly increase prolactin secretion and to induce extensive lobuloalveolar development of the mammary glands of female rhesus macaques. In accordance, a study found that CPA, in all cases, induced full lobuloalveolar development of the breasts in transgender women treated with the medication in combination with estrogen for a prolonged period of time.

Cats sometimes repeatedly tread their front paws on humans or soft objects with a kneading action. This is instinctive to kittens and adults, and is presumably derived from the action used to stimulate milk let-down by the mother during nursing. Kittens "knead" the breast while suckling, using the forelimbs one at a time in an alternating pattern to push against the mammary glands to stimulate lactation in the mother. Kneading may also have an origin going back to cats' wild ancestors who had to tread down grass or foliage to make a temporary nest in which to rest.

The model was then used to test the three different mechanisms to determine which one led to simulation results that matched in vivo experiments the best. Surprisingly, radiation-induced cell inactivation by death did not contribute to increased stem cell frequency independently of the dose delivered in the model. Instead the model revealed that the combination of increased self-renewal and cell proliferation during puberty led to stem cell enrichment. In contrast epithelial-mesenchymal transition in the model was shown to increase stem cell frequency not only in pubertal mammary glands but also in adult glands.

A more thorough examination of the phenomenon was conducted in 1982, confirming the results. A later study in 1987 further explained their previous findings. After differentiation of the mammary gland resulting from a full-term pregnancy of the rat, the rate of cell division decreases and the cell cycle length increases, allowing more time for DNA repair. Despite the fact that the Russos' studies found similar risk rates between virgin and pregnancy interrupted rats, their research would be used to support the contention that abortion created a greater risk of breast cancer for the next twenty years.

Epigenetic alterations are also carried out by another major regulatory element, that of microRNAs (miRNAs). In mammals, these small non-coding RNA molecules regulate about 60% of the transcriptional activity of protein-encoding genes. Epigenetic silencing or epigenetic over-expression of miRNA genes, caused by aberrant DNA methylation of the promoter regions controlling their expression, is a frequent event in cancer cells. Almost one third of miRNA promoters active in normal mammary cells were found to be hypermethylated in breast cancer cells, and that is a several fold greater proportion of promoters with altered methylation than is usually observed for protein coding genes.

According to Flora of the U.S.S.R. (1934, translated 1968), “A powder prepared from dried roots is used in popular medicine as a cure for rabies and crushed leaves are used against mammary congestion; fresh leaves are employed in homeopathy. [...] Since this species is often confounded or identified with others of the genus, the reported data may also refer to [Alisma orientale or Alisma lanceolatum].” Indeed, Alisma is also known as mad-dog weed, as if it could be used to cure rabies. Do not confuse this with Scutellaria lateriflora (mad-dog skullcap), which is also sometimes called mad-dog weed.

The remainder of the LDLs is removed by the liver. Adipose tissue and lactating mammary glands also take up glucose from the blood for conversion into triglycerides. This occurs in the same way as it does in the liver, except that these tissues do not release the triglycerides thus produced as VLDL into the blood. Adipose tissue cells store the triglycerides in their fat droplets, ultimately to release them again as free fatty acids and glycerol into the blood (as described above), when the plasma concentration of insulin is low, and that of glucagon and/or epinephrine is high.

Structure of Milk fat globule membrane in the mammary alveolus Milk fat globule membrane (MFGM) is a complex and unique structure composed primarily of lipids and proteins that surrounds milk fat globule secreted from the milk producing cells of humans and other mammals. It is a source of multiple bioactive compounds, including phospholipids, glycolipids, glycoproteins, and carbohydrates that have important functional roles within the brain and gut. Preclinical studies have demonstrated effects of MFGM-derived bioactive components on brain structure and function, intestinal development, and immune defense. Similarly, pediatric clinical trials have reported beneficial effects on cognitive and immune outcomes.

Also, the media published a rumor that Dmitry Baksheev allegedly confessed to a murder committed in 2012, and Natalia - to 30 murders. However, the Investigative Committee stated several times that they had no such data on a series of murders for cannibalism by a married couple and that in the Baksheev case there was only one murder. Finally, it was also rumored that during the search of the Baksheevs' apartment, 19 pieces of human skin, 7 body parts, photos of eerie dishes, canned food with human meat, including mammary glands, and even cooking recipes for humans were seized.

Exocrine glands are glands that secrete substances onto an epithelial surface by way of a duct. Examples of exocrine glands include sweat, salivary, mammary, ceruminous, lacrimal, sebaceous, prostate and mucous. Exocrine glands are one of two types of glands in the human body, the other being endocrine glands, which secrete their products directly into the bloodstream. The liver and pancreas are both exocrine and endocrine glands; they are exocrine glands because they secrete products—bile and pancreatic juice—into the gastrointestinal tract through a series of ducts, and endocrine because they secrete other substances directly into the bloodstream.

Buformin, along with phenformin and metformin, inhibits the growth and development of cancer. The anticancer property of these drugs is due to their ability to disrupt the Warburg effect and revert the cytosolic glycolysis characteristic of cancer cells to normal oxidation of pyruvate by the mitochondria. Metformin reduces liver glucose production in diabetics and disrupts the Warburg effect in cancer by AMPK activation and inhibition of the mTor pathway. Buformin decreased cancer incidence, multiplicity, and burden in chemically induced rat mammary cancer, whereas metformin and phenformin had no statistically significant effect on the carcinogenic process relative to the control group.

It can also induce a loss of cell polarity and epithelial- mesenchymal transition, leading to invasive and metastatic growth in mammary epithelial cells. The importance of c-fos in biological context has been determined by eliminating endogenous function by using anti-sense mRNA, anti- c-fos antibodies, a ribozyme that cleaves c-fos mRNA or a dominant negative mutant of c-fos. The transgenic mice thus generated are viable, demonstrating that there are c-fos dependent and independent pathways of cell proliferation, but display a range of tissue-specific developmental defects, including osteoporosis, delayed gametogenesis, lymphopenia and behavioral abnormalities.

Tyrosine kinase receptors, including the IGF-1 receptor, mediate their activity by causing the addition of a phosphate groups to particular tyrosines on certain proteins within a cell. This addition of phosphate induces what are called "cell signaling" cascades - and the usual result of activation of the IGF-1 receptor is survival and proliferation in mitosis- competent cells, and growth (hypertrophy) in tissues such as skeletal muscle and cardiac muscle. During embryonic development, the IGF-1R pathway is involved with the developing limb buds. The IGFR signalling pathway is of critical importance during normal development of mammary gland tissue during pregnancy and lactation.

The membrane at the rear is, however, supported by a calcar at the ankle. The teeth and short robust jaw allow the consumption of a wide variety of animals, either the flesh and bones of other vertebrate species or hard shells of larger invertebrates. A pregnant bat possesses two sets of teats, one pair beneath the armpits provide milk from the mammary glands and another pair at the pubic area. The pubic teats do not have a lactational function, rather they act as purchase points for the new-born to be carried in flight by the mother.

Mastitis, a potentially fatal inflammatory infection of the mammary glands, is a common health problem in dairy cows in the United States and causes great economic losses for the dairy industry each year due to reduced milk production in cows with mastitis. While the influence of contagious gram-positive bacteria (e.g. Staphylococcus and Streptococcus) – which used to be the primary cause for mastitis in dairy cows – has been significantly reduced in recent years, environmental pathogens such as coliform bacteria (e.g. E. coli) and noncontagious Streptococcus now play a larger role in the infection of dairy cows.

Metastasis is a major cause of cancer deaths, and strategies to prevent or halt invasion are lacking. One study showed that autocrine PDGFR signaling plays an essential role in epithelial-mesenchymal transition (EMT) maintenance in vitro, which is known to correlate well with metastasis in vivo. The authors showed that the metastatic potential of oncogenic mammary epithelial cells required an autocrine PDGF/PDGFR signaling loop, and that cooperation of autocrine PDGFR signaling with oncogenic was required for survival during EMT. Autocrine PDGFR signaling also contributes to maintenance of EMT, possibly through activation of STAT1 and other distinct pathways.

Colostrum is a form of milk produced by the mammary glands of mammals (including humans) in late pregnancy. Colostrum also contains multiple immune modulating molecules, including high antibody levels. Based on studies noting an overlap in the observed in vitro effects between a molecule contained in colostrum called colostrinin and the dialyzable leukocyte extract mentioned above, a hypothesis formed that the two were the same. There has been no recent research investigations comparing the two entities and thus there is no verifiable evidence that either colostrum or egg whites do or do not contain the cellular product that shares the name transfer factor.

The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein mediates the signal transduction triggered by various cell ligands, such as IL2, IL4, CSF1, and different growth hormones. It has been shown to be involved in diverse biological processes, such as TCR signaling, apoptosis, adult mammary gland development, and sexual dimorphism of liver gene expression.

These have the benefit of being inexpensive and do not require a surgical procedure to implant them under the skin. Breast reconstruction surgery, for example, can use this technique when the mammary gland is removed by surgery (mastectomy). Later, a more permanent breast implant filled with saline or silicone gel is inserted under the expanded skin pocket. In other applications, excess skin is grown purposely by expansion on the back or the buttocks, so that it can be harvested later for transplantation to another site where skin was lost due to trauma, extensive wounds, surgery, burns, etc.

The four surgical approaches to emplacing a breast implant to the implant pocket are described in anatomical relation to the pectoralis major muscle. # SubglandularThe breast implant is emplaced to the retromammary space, between the breast tissue (the mammary gland) and the pectoralis major muscle (major muscle of the chest), which most approximates the plane of normal breast tissue, and affords the most aesthetic results. Yet, in women with thin pectoral soft-tissue, the subglandular position is likelier to show the ripples and wrinkles of the underlying implant. Moreover, the capsular contracture incidence rate is slightly greater with subglandular implantation.

Serine/threonine-protein kinases SGK represent a kinase subfamily with orthologs found across animal clades and in yeast (compare Treefam family TF320906). In most vertebrates, including humans, there are three isoforms encoded by the genes SGK1, SGK2, and SGK3. The name Serum/glucocorticoid- regulated kinase refers to the first cloning of a SGK family member from a cDNA library screen for genes upregulated by the glucocorticoid dexamethasone in a rat mammary epithelial tumor cell line. The first human family member (human SGK1) was cloned in a screen of hepatocellular genes regulated in response to cellular hydration or swelling.

As part of the pre-procedure work-up, every patient has a triple- phase CT scan within a month of the scheduled embolization. Triple-phase CT is essential for documenting the extent of disease, demonstrating arterial anatomy, evaluating the portal venous system, and looking for non-hepatic blood supply to the tumor. This study serves as the basis for a treatment plan. The extent and distribution of the tumors are laid out, arterial blood supply to the tumor is evident and any contribution from the extra hepatic vasculature such as the phrenic or internal mammary arteries, should be seen.

Fig.2: DPP-4 cleaves two amino acids from the N-terminal end of peptides, such as GLP-1.DPP-4 is attached to the plasma membrane of the endothelium of almost every organ in the body. Tissues which strongly express DPP-4 include the exocrine pancreas, sweat glands, salivary and mammary glands, thymus, lymph nodes, biliary tract, kidney, liver, placenta, uterus, prostate, skin, and the capillary bed of the gut mucosa (where most GLP-1 is inactivated locally). It is also present, in soluble form, in body fluids, such as blood plasma and cerebrospinal fluid.

Birkett's most memorable contribution to his field was his treatise on diseases on the mammary gland, the very first comprehensive treatment of the subject, for which he was awarded the Jacksonian Prize by The Royal College of Surgeons of England in 1848. The dissertation was published as a book entitled The Diseases of the Breast and Their Treatment in 1850. It was 258 pages long, with 12 plates. Birkett's work fell into obscurity for 150 years, and both it and he himself (in the context of breast disease at least) were largely forgotten by medical historians.

Mammatus clouds in the Nepal Himalayas Mammatus (mamma or mammatocumulus), meaning "mammary cloud", is a cellular pattern of pouches hanging underneath the base of a cloud, typically cumulonimbus rainclouds, although they may be attached to other classes of parent clouds. The name mammatus is derived from the Latin mamma (meaning "udder" or "breast"). According to the WMO International Cloud Atlas, mamma is a cloud supplementary feature rather than a genus, species or variety of cloud. They are formed by cold air sinking down to form the pockets contrary to the puffs of clouds rising through the convection of warm air.

Calcitriol synthesis Calcitriol is produced in the cells of the proximal tubule of the nephron in the kidneys by the action of 25-hydroxyvitamin D3 1-alpha-hydroxylase, a mitochondrial oxygenase and an enzyme which catalyzes the hydroxylation of 25-hydroxycholecalciferol (calcifediol) in the 1-alpha position. The activity of this enzyme is stimulated by PTH. This is an important control point in Ca2+ homeostasis. Additional effects on the production of calcitriol include an increase by prolactin, a hormone which stimulates lactogenesis (the formation of milk in mammary glands), a process which requires large amounts of calcium.

Progesterone levels during female puberty do not normally increase importantly until near the end of puberty in cisgender girls, a point by which most breast development has already been completed. In addition, concern has been expressed that premature exposure to progestogens during the process of breast development is unphysiological and might compromise final breast growth outcome, although this notion presently remains theoretical. Though the role of progestogens in pubertal breast development is uncertain, progesterone is essential for lobuloalveolar maturation of the mammary glands during pregnancy. Hence, progestogens are required for any transgender woman who wishes to lactate or breastfeed.

Sensory inputs (vocalisation, odours from mammary and birth fluids and hair patterns of the sow) are particularly important immediately post-birth to facilitate teat location by the piglets. Initially, the piglets compete for position at the udder; then the piglets massage around their respective teats with their snouts, during which time the sow grunts at slow, regular intervals. Each series of grunts varies in frequency, tone and magnitude, indicating the stages of nursing to the piglets. The phase of competition for teats and of nosing the udder lasts for about one minute, and ends when milk flow begins.

The genus Apomys, of which the Luzon montane forest mouse is a member, can be identified by its small size, long tail, elongate, narrow hind feet, the presence of four abdominal mammary glands, and a large number of skull characteristics. The Luzon montane forest mouse is a large, thickset species with a tail that is about the same length as the body. The soft, thick dorsal fur is dark brown, while the ventral side of the body is a cream white. The hind feet are partly brown in colour on the dorsal side, but otherwise white.

In June 2012, a new drug candidate named "Rhosin" was synthesized by researchers at the Cincinnati Children's Hospital, a drug with the full intention to inhibit cancer proliferation and promote nerve cell regeneration. This inhibitor specifically targets Rho GTPases to prevent cell growth related to cancer. When tested on breast cancer cells, Rhosin inhibited growth and the growth of mammary spheres in a dose dependent manner, functioning as targets for RhoA while simultaneously maintaining the integrity of normal cellular processes and normal breast cells. These promising results indicate Rhosin's general effectiveness in preventing breast cancer proliferation via RhoA targeting.

Coagulation factor VIIa (recombinant)-jncw (Sevenfact) is expressed in the mammary gland of genetically engineered rabbits and secreted into the rabbits' milk. During purification and processing of the milk, FVII is converted into activated FVII (FVIIa). The recombinant DNA (rDNA) construct in the genetically engineered rabbits used for the production of Sevenfact was approved by the FDA's Center for Veterinary Medicine. The safety and efficacy of coagulation factor VIIa (recombinant)-jncw were determined using data from a clinical study that evaluated 27 patients with hemophilia A or B with inhibitors, which included treatment of 465 mild or moderate, and three severe bleeding episodes.

Beef pyeonyuk mainly uses brisket, plate, foreshank, tongue, testicle, mammary, head, liver, spleen, and trotters, while pork pyeonyuk uses belly, head, and trotters. The meat is always soaked in cold water to remove blood, and it is boiled as a whole chunk until tender. The broth for cooking the meat is flavored with salt and other seasonings that may vary from household to household, and can include doenjang (soybean paste), soju, cheongju (rice wine), black peppercorns, or coffee powder. Scallions and whole garlic cloves are a common addition in the broth when beef is used, and sliced ginger for pork.

The report that was released by Sugiura of his findings of the experiment are as follows: The results clearly show that Amygdalin(Laetrile) significantly inhibits the appearance of lung metastasis in mice bearing spontaneous mammary tumors and increases significantly the inhibition of the growth of the primary tumors....Laetrile also seemed to prevent slightly the appearance of new tumors....The improvement of health and appearance of the treated animals in comparison to controls is always a common observation....Dr. Sugiura has never observed complete regression of these tumors in all his cosmic experience with other chemotherapeutic agents.

A surgical operation to remove a malignant tumor, 1817 In the 16th and 17th centuries, it became more acceptable for doctors to dissect bodies to discover the cause of death. The German professor Wilhelm Fabry believed that breast cancer was caused by a milk clot in a mammary duct. The Dutch professor Francois de la Boe Sylvius, a follower of Descartes, believed that all disease was the outcome of chemical processes, and that acidic lymph fluid was the cause of cancer. His contemporary Nicolaes Tulp believed that cancer was a poison that slowly spreads, and concluded that it was contagious.

Interestingly, even after oncogenic activation of a tissue, several researchers have identified a senescent phenotype. Researchers have identified a senescent phenotype in benign lesions of the skin carrying oncogenic mutations in neurofibroma patients with a defect that specifically causes an increase in Ras. This finding has been highly reproducible in benign prostate lesions, in melanocytic lesions of UV-irradiated HGF/SF-transgenic mice, in lymphocytes and in the mammary gland from N-Ras transgenic mice, and in hyperplasias of the pituitary gland of mice with deregulated E2F activity. The key to these findings is that genetic manipulations that abrogated the senescence response led to full-blown malignancy in those carcinomas.

Importantly, the histopathology of these tumors was indistinguishable from that of the parental tumors that develop in the MMTV-Neu mice. Application of the CRC system to mouse mammary epithelial cells provides an attractive model system to study the genetics and phenotype of normal and transformed mouse epithelium in a defined culture environment and in vivo transplant studies. A different approach to CRC is to inhibit CD47 – a membrane protein that is the thrombospondin-1 receptor. Loss of CD47 permits sustained proliferation of primary murine endothelial cells, increases asymmetric division and enables these cells to spontaneously reprogram to form multipotent embryoid body-like clusters.

TCD's role in cancer increasing with the rise of immunotherapies being investigated, specifically those that target self- antigens. One example is antigen-specific CD4+ T cell tolerance, which serves as the primary mechanism restricting immunotherapeutic responses to the endogenous self antigen guanylyl cyclase c (GUCY2C) in colorectal cancer. However, in some cases, selective CD4+ T cell tolerance provides a unique therapeutic opportunity to maximize self antigen-targeted immune and antitumor responses without inducing autoimmunity by incorporating self antigen- independent CD4+ T cell epitopes into cancer vaccines. In a mammary carcinoma model, depletion of CD25+ regulatory T cells increase the amount of CD8+CD11c+PD110, which target and kill the tumors.

After an eight-year project involving the use of a pioneering cloning technique, Japanese researchers created 25 generations of healthy cloned mice with normal lifespans, demonstrating that clones are not intrinsically shorter-lived than naturally born animals. Other sources have noted that the offspring of clones tend to be healthier than the original clones and indistinguishable from animals produced naturally. Dolly the sheep was cloned from a six-year old cell sample from a mammary gland. Because of this, some posited she may have aged more quickly than other naturally born animals, as she died relatively early for a sheep at the age of six.

In India, mammals comprise 410 species, 186 genera, 45 families and 13 orders of which nearly 89 species are listed as threatened in the International Union for Conservation of Nature and Natural Resources (IUCN) Red List of Threatened Animals (IUCN 2006). This includes two species that are locally extinct from India viz. Acinonyx jubatus and Rhinoceros sondaicus. The mammals are the class of vertebrate animals characterized by the presence of mammary glands, which in females produce milk for the nourishment of young; the presence of hair or fur; specialized teeth; the presence of a neocortex region in the brain; and endothermic or "warm-blooded" bodies.

Female ruffed lemurs have three pairs of mammary glands for feeding their large litters Ruffed lemurs are the only known primates to build arboreal nests, used exclusively for birth and for the first week or two of life. Starting three weeks prior to birth, females begin constructing the nest from twigs, branches, leaves, and vines, locating it within her core area and above ground. The nests have only one apparent entry point, and are shallow and dish-shaped. During the first couple of weeks, the mother is mostly solitary and does not travel far from the nest, spending as much as 70–90% of her time with the newborns (in captivity).

Aliens versus Predator: Chained to Life and Death Though female Predators are occasionally referred to in Steve and Stephani Perry's novel series, one does not make an appearance until the comic book limited series Aliens vs Predator: Deadliest of Species. The female's design contradicts the descriptions given in the Perry novel series, as it superficially shows little distinction from males. The Darkhorse/TopCow crossover MindHunter, which pits the Witchblade, The Darkness, Aliens, and Predator franchises against each other, depicts a female Predator in a manner closer to the Perry description. It is very tall, has feminine hips, mammary glands, and a very muscular build, with different armor than the males.

Spaying and neutering can also decrease the risk of hormone-driven diseases such as mammary cancer, as well as undesired hormone- driven behaviors. However, certain medical problems are more likely after surgery, such as urinary incontinence in females and prostate cancer in males. The hormonal changes involved with sterilization are likely to somewhat change the animal's personality, however, and some object to spaying and neutering as the sterilization could be carried out without the excision of organs. It is not essential for a female dog to either experience a heat cycle or have puppies before spaying, and likewise, a male dog does not need the experience of mating before neutering.

After qualifying as a physician Bennett obtained employment as a ship's surgeon, and visited Sydney, New South Wales, in 1829. ln 1832 his friend Richard Owen was engaged in examining the structure and relations of the mammary glands of the Ornithorhyncus, and Bennett became so interested that on leaving England shortly afterwards for Australia he determined while in that country to find a solution of the question. In May 1832 Bennett left Plymouth on a voyage which terminated almost exactly two years later. An account of this appeared in 1834 in two volumes under the title Wanderings in New South Wales, Batavia, Pedir Coast, Singapore and China.

ZBTB32 is highly expressed spermatogonial stem cells, in hematopoietic stem and progenitor cells (please also refer to the RNA expression pattern to the right), in diffuse large B-cell lymphoma (DLBCL) and appears to suppress the immune system by silencing the CIITA gene. The transcription factor gene GATA3 is altered in mammary tumors. Down-regulation of GATA3 expression and activity by the Zinc-finger elbow-related proline domain protein 2 (Zpo2), whereas Zbtb32 facilitates Zpo2 targeting to the GATA3 promoter, results in the development of aggressive breast cancers. A DNA methylation correlation network was built based on the methylation correlation between differentially methylated genes.

The function of ACC is to regulate the metabolism of fatty acids. When the enzyme is active, the product, malonyl-CoA, is produced which is a building block for new fatty acids and can inhibit the transfer of the fatty acyl group from acyl CoA to carnitine with carnitine acyltransferase, which inhibits the beta-oxidation of fatty acids in the mitochondria. In mammals, two main isoforms of ACC are expressed, ACC1 and ACC2, which differ in both tissue distribution and function. ACC1 is found in the cytoplasm of all cells but is enriched in lipogenic tissue, such as adipose tissue and lactating mammary glands, where fatty acid synthesis is important.

The fact that the heterozygous parents and heterozygous sister were unaffected indicates that the disorder is transmitted in an autosomal recessive manner and that a single normal allele is sufficient to achieve normal puberty and fertility, which is consistent with what has been observed in ERα knockout mice. All three siblings presented with pubertal failure. Both of the sisters had no breast development (i.e., Tanner stage I), illustrating how the ERα is absolutely required for normal mammary gland development. The older sister was overweight ( 26.3) and had mild incidental adipomastia, or adipose tissue deposition in the breasts without true glandular tissue, a trait that is not indicative of pubertal development.

In humans, fatty acids are formed from carbohydrates predominantly in the liver and adipose tissue, as well as in the mammary glands during lactation. The cells of the central nervous system probably also make most of the fatty acids needed for the phospholipids of their extensive membranes from glucose, as blood-born fatty acids cannot cross the blood brain barrier to reach these cells. However, how the essential fatty acids, which mammals cannot synthesize themselves, but are nevertheless important components of cell membranes (and other functions described above) reach them is unknown. The pyruvate produced by glycolysis is an important intermediary in the conversion of carbohydrates into fatty acids and cholesterol.

Several mouse strains carry the virus endogenously, but it is also transmitted vertically via milk from mother to pup. It is contained as a DNA provirus integrated in the DNA of milk lymphocytes. The viruses become transported through the gastrointestinal tract to the Peyer's patches where they infect the new host's macrophages, and then lymphocytes. The mouse mammary tumor virus (MMTV) has formerly been classified as a simple retrovirus; however, it has recently been established, that MMTV encodes an extra self-regulatory mRNA export protein, Rem, with resemblance to the Human Immunodeficiency Virus HIV Rev protein, and is therefore the first complex murine retrovirus to be documented.

Chuck makes the connection that Lizzie had previously made 29 deliveries, and 29 bugs had been found in the store. He sneaks out of Big Mike's office through the ceiling and finds the "Mammary Cam" recording in Jeff and Lester's secret hiding spot. He returns to the office and uses Big Mike's computer to view the video, and confirms his suspicions and sees Jeff and Lester had caught Lizzie planting a bug without realizing it. Lizzie is the Fulcrum agent and Chuck hurriedly sends Sarah an e-mail before Big Mike and Conway return, after which they let him leave and call in Casey before he can further interrogate Morgan.

To understand the pathogenesis of cancer patients, it is necessary to have model systems that faithfully mimic this condition. The application of a murine cancer cell line, such as 4T1, in a mouse model is of great value for preclinical TNBC studies. The 4T1 cell line is widely used as a syngeneic model for human triple-negative breast cancer, which is responsible for more than 17% of breast cancers diagnosed worldwide each year. 4T1 cells can be transplanted into the fat pad of the murine mammary gland, where they are highly tumorigenic, invasive, and spontaneously metastasize to distant organs such as the lungs, liver, lymph nodes, brain, and bone.

BST increases the longevity or the activity of the mammary cell leading to higher milk production and some other non-desirable side effects. Despite public controversy of the use of growth hormones in food-producing animals, the number of violations has decreased substantially in the past two decades. For comparison, the level of rBST detected in bulk milk tank trucks in 2012 was one fifth the level that it was in 1996. As reported by the USDA, the US pattern for milk BTSCC declined steadily from 316,000 cells per mL of milk in 2001 to 224,000 cells/mL in 2010 and 206,000 cells/mL in 2011 (USDA, 2013).

Dog appeasing pheromone is secreted by lactating dogs Dog appeasing pheromone (DAP), sometimes known as apasine, is a mixture of esters of fatty acids released by the sebaceous glands in the inter-mammary sulcus of lactating female dogs. It is secreted from between three and four days after parturition and two to five days after weaning. DAP is believed to be detected by the vomeronasal organ (Jacobson's organ) and has an appeasing effect on both adults and pups, and assists in establishing a bond with the mother. Synthetic DAP analogues have been developed which may support dogs during some, but not all, stressful situations.

Anagestone acetate was introduced in combination with mestranol as a birth control pill in 1968 by Ortho Pharmaceutical. It was withdrawn in 1969. In 1969, along with a variety of other progestogens including progesterone, chlormadinone acetate, megestrol acetate, medroxyprogesterone acetate, ethynerone, and chloroethynyl norgestrel, anagestone acetate was found to induce the development of mammary gland tumors in Beagle dogs after extensive treatment (2–7 years) with very high doses (10–25 times the recommended human dose), though notably not with 1–2 times the human dosage. In contrast, the non-halogenated 19-nortestosterone derivatives norgestrel, norethisterone, noretynodrel, and etynodiol diacetate were not found to produce such nodules.

However, despite being reptilian, the females also possesses hair and mammary glands to nurture their newborn, just like a human being. The Skrulls later developed the ability to render themselves undetectable when using their shapeshifting abilities, even from telepaths and those with superior senses. Reed Richards discovered a method to use technology to negate this ability and reveal a disguised Skrull's true form. Courtesy of their advanced technology, the Skrulls have also been able to augment their abilities in certain warriors, such as the Super-Skrull and War Skrulls—an elite group who with special encoding are able to emulate the powers as well as appearance of their templates.

This maternal recognition of pregnancy will cause persistence of the corpus luteum and the development of characteristics and behaviors necessary to care for offspring. Limited research suggests that progesterone secretion is similar in pregnant and non-pregnant female dogs, so veterinary researchers hypothesize that they may not require molecular factors from the embryo for maternal recognition of pregnancy, and instead the corpus luteum persists regardless of pregnancy. Since the corpus luteum is not degraded, it will cause the development of maternal characteristics in the absence of pregnancy. Pseudopregnant dogs will develop their mammary glands, lactate, and build nests to varying degrees depending on breed.

In approximately half of all human mammary carcinomas, Numb-mediated suppression of Notch signaling is lost due to Numb ubiquitination, tagging it for proteasomal degradation. Numb acts as an oncogene suppressor, inhibiting tumor cell proliferation through suppression of Notch signaling. Increased Notch signaling is observed in tumors where Numb activity has been lost and retrovirally mediated transient overexpression of Numb protein in these tumors restored basal levels of Notch signaling and significantly reduced their colony-forming abilities. Thus, the biological antagonism between Notch and Numb signaling that controls the proliferative/differentiative balance of many cell lineages appears to play a role in human breast carcinogenesis and perhaps other types of tumorigenesis.

The mammary glands of the females do not store significant quantities of milk as most other mammals do, since the infant sloth remains attached to the nipple at all times, and consumes the milk as soon as it is generated. The young begin to take solid food as early as four days after birth, initially licking particles of food from their mother's mouths. This process apparently allows them to quickly identify edible leaves, and young sloths typically have the same preferences for leaf types as their mothers. In the wild, the lifespan of adult brown-throated three-toed sloths is typically between 30 and 40 years.

Because of its roles in cancer, several studies have considered the potential value of NEDD9 as a therapeutic target or therapeutic guide. Because of lack of a kinase domain, or any defined catalytic domain, and because it is entirely intracellular, NEDD9 is a difficult molecule to target. Because NEDD9 serves as a scaffolding molecule for other signaling proteins that play significant roles in cancer development, the effects of NEDD9 overexpression in supporting metastasis could in theory be mitigated by inhibition of its downstream targets. In one study, deletion of Nedd9 in MMTV-neu mammary tumors increased their sensitivity to inhbitiors of FAK and SRC.

Expression levels of TCTP were down-regulated at the mRNA and protein levels during tumor suppression and by the activation of p53 and Siah-1 very well known anti-tumor genes. Down-regulation of TCTP can induce tumor reversion, and in combination with some drugs that decrease the level of TCTP and will lead to kill tumor cells. TCTP knockdown in primary mammary tumor cells, results in increased p53 expression and a decreased number of stem-like cancer cells. Reducing TCTP (dTCTP) levels in Drosophila reduces cell size, cell number and organ size, which mimics Drosophila Rheb (dRheb) mutant phenotypes; human TCTP (hTCTP) shows similar biochemical properties compared to dTCTP.

Mammary analogue secretory carcinoma occurs somewhat more commonly in men (male to female ratio of <1.5:1.0). Patients with this disease have a mean age of 46 years although ~12% of cases occur in pediatric patients. Individuals typically present with symptomless tumors in the parotid salivary gland (68%), buccal mucosa salivary glands (9%), submandibular salivary gland (8%) or in the small salivary glands of the lower lip (5%), upper lip (4%), and hard palate (4%). Histologically, these tumors are described as have a morphology similar to secretory breast carcinoma; they typically having one or more of the following histological patterns: microcystic, papillary-cystic, follicular, and/or solid lobular.

No clinical study has assessed the use of progesterone in transgender women, and only a couple of studies have compared the use of progestins (specifically cyproterone acetate and medroxyprogesterone acetate) versus the use of no progestogen in transgender women. These studies, albeit limited in the quality of their findings, reported no benefit of progestogens on breast development in transgender women. This has also been the case in limited clinical experience. These reports are in accordance with the normal and even above-average breast development in women with complete androgen insensitivity syndrome, who lack progesterone and have no lobuloalveolar development of the mammary glands on histological examination.

On the other hand, it appears that estriol may be able to stimulate the growth of active breast cancer. In rodents, estriol induces mammary gland development similar to that with estrone. By the oral route in women, estriol has approximately 30% of the potency of estradiol in terms of hot flashes relief and suppression of follicle-stimulating hormone secretion, and about 20% of the potency of estradiol on stimulation of liver production of high-density lipoprotein (HDL) cholesterol. A study of ovulation inhibition by estrogens in women found that prevention of ovulation occurred with 5 mg/day oral estriol in only 1 of 7 cycles.

E2-EN/DHPA was first studied as a combined injectable contraceptive in 1964. It was developed by Squibb under the developmental code name and tentative brand name Deladroxate for potential use as a combined injectable contraceptive in the United States. Due to toxicological findings of DHPA of pituitary hyperplasia in rats, mammary tumors in beagle dogs, and "uterine swellings" in animals, as well as concerns about possible accumulation of DHPA, Squibb discontinued the development of E2-EN/DHPA in the late 1960s. Subsequently, in 1973, a pharmacokinetic study of E2-EN/DHPA in women generated concerns about potential accumulation of E2-EN with once- monthly use as well.

Chemical compounds with a high affinity for lipids (a higher log Kow) will more readily be transferred through lactation due to the high lipid content of milk. The transfer of toxicants from blubber to milk is not fully understood, and selective transfer of contaminants has been observed. Mass balance of toxicants is difficult during lactation due to milk lipids originating from blubber lipids as well as being synthesized locally in mammary tissue. The change in toxicant solubility between blubber and circulatory fluid as well as the breakdown and resynthesis of blubber lipids and circulatory lipids also contributes to the difficulties of mass balance of toxicants between blubber, circulatory, and milk lipids.

As in vertebral-subclavian steal, coronary-subclavian steal may occur in patients who have received a coronary artery bypass graft using the internal thoracic artery (ITA), also known as internal mammary artery. As a result of this procedure, the distal end of the ITA is diverted to one of the coronary arteries (typically the LAD), facilitating blood supply to the heart. In the setting of increased resistance in the proximal subclavian artery, blood may flow backward away from the heart along the ITA, causing myocardial ischemia due to coronary steal. Vertebral-subclavian and coronary-subclavian steal can occur concurrently in patients with an ITA CABG.

Hair has its origins in the common ancestor of mammals, the synapsids, about 300 million years ago. It is currently unknown at what stage the synapsids acquired mammalian characteristics such as body hair and mammary glands, as the fossils only rarely provide direct evidence for soft tissues. Skin impression of the belly and lower tail of a pelycosaur, possibly Haptodus shows the basal synapsid stock bore transverse rows of rectangular scutes, similar to those of a modern crocodile. An exceptionally well-preserved skull of Estemmenosuchus, a therapsid from the Upper Permian, shows smooth, hairless skin with what appears to be glandular depressions,Kardong, K.V. (2002): Vertebrates: Comparative anatomy, function, evolution.

Expression of the PRLR protein is found within cells of the mammary glands in accordance with its role in lactation, but also is the subject of attention for its diverse and emerging roles by its expression in adipose tissue, pancreatic islet cell proliferation, and immune responses. The PRLR is a cytokine receptor and second messenger cascades include the JAK-STAT pathway, JAK-RUSH pathway, Ras-Raf-MAPK, and PI3K/AKT/mTOR pathway. Disruption of PRLR signaling pathways have been linked to tumorigenesis and breast cancer development.Z. Nouhi, N. Chughtai, S. Hartley, E. Cocolakis, J.J. Lebrun, S. Ali Defining the role of prolactin as an invasion suppressor hormone in breast cancer cells Cancer Res, 66 (2006), pp.

In the 1990s it was widely used as a recipient cell line for the transduction of cytokine genes and other genes of immunological interest, to produce recombinant experimental vaccines that induced anti-tumor immunological responses.Allione A, M Consalvo, P Nanni, P-L Lollini, F Cavallo, M Giovarelli, M Forni, A Gulino, MP Colombo, P Dellabona, H Hock, T Blankenstein, FM Rosenthal, B Gansbacher, MC Bosco, T Musso, L Gusella, and Guido Forni. 1994. "Immunizing and curative potential of replicating and nonreplicating murine mammary adenocarcinoma cells engineered with interleukin (IL)-2, IL-4, IL-6, IL-7, IL-10, tumor necrosis factor alpha, granulocyte-macrophage colony-stimulating factor, and gamma-interferon gene or admixed with conventional adjuvants". Cancer Research.

Bisphenol A (BPA) is a chemical used to make plastics, and is frequently used to make baby bottles, water bottles, sports equipment, medical devices, and as a coating in food and beverage cans. Scientists are concerned about BPA's behavioral effects on fetuses, infants, and children at current exposure levels because it can affect the prostate gland, mammary gland, and lead to early puberty in girls. BPA mimics and interferes with the action of estrogen—an important reproduction and development regulator. It leaches out of plastic into liquids and foods, and the Centers for Disease Control and Prevention (CDC) found measurable amounts of BPA in the bodies of more than 90 percent of the U.S. population studied.

GPR31 receptor mRNA is highly expressed in the PC-3 prostate cancer cell line and to a lesser extent the DU145 prostate cancer cell line and to human umbilical vein endothelial cells (HUVEC), human umbilical vein endothelial cells (HUVEC), human brain microvascular endothelial cells (HBMEC), and human pulmonary aortic endothelial cells (HPAC). Its mRNA is also express but at rather low levels in several other human cell lines including: K562 cells (human myelogenous leukemia cells); Jurkat cells (T lymphocyte cells); Hut78 cells (T cell lymphoma cells), HEK 293 cells (primary embryonic kidney cells), MCF-7 cells (mammary adenocarcinoma cellss), and EJ cells (bladder carcinoma cells). Mice express an ortholog to human GPR31 in their circulating blood platelets.

Deregulation of CK1δ contributes to tumorigenesis and tumor progression through deregulation of Wnt/β-catenin-, p53-, Hedgehog-, and Hippo-related signaling. CK1δ mRNA is overexpressed in various cancer entities, among them bladder cancer, brain cancer, breast cancer, colorectal cancer, kidney cancer, lung adenocarcinoma, melanoma, ovarian cancer, pancreatic cancer, prostate cancer, hematopoietic malignancies and lymphoid neoplasms. Also decreased CK1δ mRNA expression levels have been observed in some cancer studies, like urinary bladder cancer, lung squamous cell carcinoma, stomach cancer, kidney cancer, esophageal cancer as well as head and neck cancer. Besides those, reduced CK1δ activity owing to the site N172D mutation of CK1δ decelerated mammary carcinoma progression, and prolonged mouse survival in a transgenic mouse model.

This protolacteal fluid became a complex, nutrient-rich milk which then allowed a decline in egg size by reducing the dependence on a large yolk in the egg.[20] The evolution of lactation is also believed to have resulted in the more complex dentition seen in mammals, as lactation would have allowed the prolonged development of the jaw before the eruption of teeth. During early evolution of lactation, the secretion of milk was through pilosebaceous glands on mammary patches, analogous to the areola, and hairs on this patch transported the nourishing fluids to the hatchlings as is seen in monotremes. The development of the nipple occurred in the mammal lineages that diverged after monotremes, metatheria and eutheria.

Disruption of hedgehog signaling during embryonic development, through either deleterious mutation or consumption of teratogens by the gestating mother, can lead to severe developmental abnormalities. Holoprosencephaly, the failure of the embryonic prosencephalon to divide to form cerebral hemispheres, occurs with a frequency of about 1 in 8,000 live births and about 1 in 200 spontaneous abortions in humans and is commonly linked to mutations in genes involved in the hedgehog pathway, including SHH and PTCH. Cyclopia, one of the most severe defects of holoprosencephaly, results if the pathway inhibitor cyclopamine is consumed by gestating mammals. Activation of the hedgehog pathway has been implicated in the development of cancers in various organs, including brain, lung, mammary gland, prostate and skin.

After the Brodies demonstrated the reduction of estrogen levels in rodents and its biological efficacy with regression of rat mammary tumors, Angela Brodie went to Rome in the fall 1981 to give a presentation about her research. At the presentation was Charles Coombes a medical oncologist who expressed his interests in conducting a clinical trial with 4-hydroxy-androstenedione (4-OH-A) to treat breast cancer. The collaboration of Angela Brodie, Charles Coombes a clinical oncologist, Paul Goss a clinical ongologist and Mitch Dowsett a clinical chemist and made this possible. Further clinical development was made with the help of Ciba-Geigy (now Novartis), (4-OH-A) given the new name Formestane.

Studies have shown that PR-B activation is important for growth and development of the mammary gland, whereas PR-A has a significant role in normal reproductive function and ovulation. As well, in vitro researches have demonstrated that under identical conditions, the PR-B works as stronger transactivator of reporter genes, while PR-A is able to transrepress PR-B and other steroid receptors. Various reasons have been found for this variety of function between the isoforms. First to mention is that progesterone receptor isoform A lacks 164 N-terminal amino acids compared to isomer B, depriving it of the AF-3 activation function due to loss of B-upstream segment, which leaves it with only 2 activation functions.

Pompeiian wall painting (Secret Museum, Naples) Latin words for "breasts" include mammae (cf. English "mammary"), papillae (more specifically for "nipples"), and ubera, breasts in their capacity to provide nourishment, including the teats or udder of an animal.Breasts are never ubera in Ovid's Amores, but are ubera throughout the Metamorphoses: at 3.31 (metaphorically); 4.324; 10.392; 9.358 (materna ... ubera, "motherly breasts"); 7.321 and 6.342 (lactantia ubera, "milk-producing breasts"); 15.117 and 472. Uber (singular) or ubera is used for animals by Ovid, Ars Amatoria 1.350 (the udder of a cow) and 2.375 (the teats of lactating dogs); by Horace, Sermones 1.1.110, Odes 2.19.10, 4.4.14 and 4.15.5, and elsewhere; by Tibullus, for sheep in 1.3.45; by Propertius, 2.34b.

Spaying (females) and neutering (males) refers to the sterilization of animals—usually by castration (removal of the male's testicles) or ovariohysterectomy (removal of the female's ovaries and uterus)—to eliminate the ability to procreate, and reduce sex drive. Castration has also been known to reduce aggression in male dogs (in some cases), but spaying has been shown to occasionally increase aggression in female dogs. Animal control agencies in the United States and the ASPCA advise that dogs not intended for further breeding should be spayed or neutered so that they do not have undesired puppies. Spaying and castrating can decrease the risk of hormone-driven diseases such as mammary cancer, as well as undesired hormone-driven behaviors.

The CALCRL or CLR KO mouse recapitulates the same phenotype, as it lacks both the AM1 and AM2 receptors (incidentally confirming the lack of physiological significance for the earlier single protein AM receptor discovered by Kapas). RAMP2 KO mice also recapitulates the same phenotype showing that major physiological effects of AM are transduced by the AM1 receptor. Even the heterozygote RAMP 2 mice have disturbed physiology with unusual bone and mammary gland defects, and very aberrant endocrinology, leading to poor fertility and lactation problems. What is very surprising is that the effect of deletion of RAMP3 has no deleterious effects and seems to confer advantages due to higher than normal bone mass, and reduced weight gain in older age.

If a Skye is exercised too often, too young, especially before 8 months, they can damage their bone growth, leading to a painful limp and possibly badly bowed legs. Jumping up and down from objects, climbing over objects, running, even long walks, are all things to be avoided for the first 8 to 10 months to prevent later problems and allow for correct closure of the growth plate. Degenerative disc disease is also a common problem in short-legged dogs; as many as 10% of Skyes will suffer from it. Mammary cancer is the leading cause of Skye Terrier deaths, with hemangiosarcomas (a malignant tumour of the blood vessels), autoimmune disease, and hyperthyroidism as other concerns of the breed.

Monotreme eggs are retained for some time within the mother and receive nutrients directly from her, and they generally hatch within 10 days after laying, much shorter than the incubation period of sauropsid eggs. Newborn monotremes, called "puggles", are larval and fetus- like, much like newborn marsupials (and perhaps all non-placental mammals), and like them have relatively well-developed forelimbs that enable them to crawl around. In fact, because monotremes lack nipples, their puggles crawl about more frequently than marsupial joeys in search of milk; this difference raises questions about the supposed developmental restrictions on marsupial forelimbs. Monotremes lactate from their mammary glands via openings in their skin, rather than through nipples.

Broparestrol () (brand names Acnestrol, Longestrol; former developmental code name LN-107), also known as α-bromo-α,β-diphenyl-β-p-ethylphenylethylene (BDPE), is a synthetic, nonsteroidal selective estrogen receptor modulator (SERM) of the triphenylethylene group that has been used in Europe as a dermatological agent and for the treatment of breast cancer. The drug is described as slightly estrogenic and potently antiestrogenic, and inhibits mammary gland development and suppresses prolactin levels in animals. It is structurally related to clomifene and diethylstilbestrol. Broparestrol is a mixture of E- and Z- isomers (LN-1643 and LN-2299, respectively), both of which are active and are similarly antiestrogenic but, unlike broparestrol, were never marketed.

An apocrine sweat gland (; from Greek apo– "away" and krinein "to separate") is composed of a coiled secretory portion located at the junction of the dermis and subcutaneous fat, from which a straight portion inserts and secretes into the infundibular portion of the hair follicle. In humans, apocrine sweat glands are found only in certain locations of the body: the axillae (armpits), areola and nipples of the breast, ear canal, eyelids, wings of the nostril, perianal region, and some parts of the external genitalia. Modified apocrine glands include the ciliary glands in the eyelids; the ceruminous glands, which produce ear wax; and the mammary glands, which produce milk. The rest of the body is covered by eccrine sweat glands.

A woman develops large breasts usually during thelarche (the pubertal breast-development stage), but large breasts can also develop postpartum, after gaining weight, at menopause, and at any age. Whereas macromastia usually develops in consequence to the hypertrophy (overdevelopment) of adipose fat, rather than to milk-gland hypertrophy. Moreover, many women are genetically predisposed to developing large breasts, the size and weight of which often are increased either by pregnancy or by weight gain, or by both conditions; there also exist iatrogenic (physician- caused) conditions such as post–mastectomy and post–lumpectomy asymmetry. Nonetheless, it is statistically rare for a young woman to experience virginal mammary hypertrophy that results in massive, oversized breasts, and recurrent breast hypertrophy.

A reduction mammoplasty to re-size enlarged breasts and to correct breast ptosis resects (cuts and removes) excess tissues (glandular, adipose, skin), overstretched suspensory ligaments, and transposes the NAC higher upon the breast hemisphere. At puberty, the breast grows in consequence to the influences of the hormones estrogen and progesterone; as a mammary gland the breast is composed of lobules of glandular tissue, each of which is drained by a lactiferous duct that empties to the nipple. Most of the volume (ca. 90%) and rounded contour of the breasts are conferred by the adipose fat interspersed amongst the lobules – except during pregnancy and lactation, when breast milk constitutes most of the breast volume.

Cis is approximately ten times more potent than trans. However, trans isomer is the most potent stimulator of epithelial cell hypertrophy since clomifene is antagonistic at low doses and agonistic at high doses. The antagonist isomers may cause inhibitory estrogenic effects in the uterus and mammary cancers, but the estrogenic isomer could combine with novel receptors to produce estrogen- like effects in bone. Figure 7: Chemical structure of tamoxifen Tamoxifen ((Z)-2-[4-(1,2-diphenylbut-1-enyl)phenoxy]-N,N-dimethyl-ethanamine; see figure 7) has become the treatment of choice for women diagnosed with all stages of hormone-responsive breast cancer, that is, breast cancer that is both ER and/or progesterone positive.

It was once believed that female cats and dogs should not be spayed until the animal delivered one litter or, at least, experienced one estrus or “heat” cycle. (There was little concern about neutering males, other than for behavioral reasons, since males do not get pregnant.) Research in the 1960s proved that female animals permitted to reach sexual maturity prior to being spayed were susceptible to a higher risk of mammary cancer than those animals spayed prior to their first cycle. As a result, the recommendation was revised to perform surgeries just prior to the average anticipated age for the first cycle, 4 to 6 months for cats and 6 to 12 months for dogs.Rosebrook, Dr. Dick.

Estetrol has potent estrogenic effects in bone, vagina, uterus (both myometrium and endometrium), arteries, and certain areas of the brain like the pituitary gland and hypothalamus (in terms of hot flash relief, antigonadotropic effects, and ovulation inhibition). It has comparable efficacy to ethinylestradiol on bone turnover and hot flashes and to estradiol valerate on vaginal atrophy. In addition, estetrol has stimulatory effects on the endometrium and poses a risk of endometrial hyperplasia and endometrial cancer similarly to other estrogens. Conversely, the effects of estetrol in certain other tissues such as breast/mammary gland, liver, vascular tissue, and various brain areas differ, with weakly estrogenic or even antiestrogenic effects occurring in such tissues.

Her research there focused on the genetic and molecular causes of cancer, including investigation of the roles of tumor suppressor genes, DNA methylation, and chromosomal instability in tumor growth and spread. Sager was one of the first people to emphasize the importance of such genes. She identified over 100 potential tumor suppressor genes and performed extensive research into a specific tumor suppressor gene called maspin (mammary serine protease inhibitor) She developed cell culture methods to study normal and cancerous human and other mammalian cells in the laboratory and pioneered the research into "expression genetics," the study of altered gene expression. She was elected a fellow of the National Academy of Sciences in 1977 and the American Academy of Arts and Sciences in 1979.

A microscopy image of a sample of human breast milk The human milk microbiota, also known as human milk probiotics (HMP), refers to the microbiota (community of microorganisms) residing in the human mammary glands and breast milk. Human breast milk has been traditionally assumed to be sterile, but more recently both microbial culture and culture-independent techniques have confirmed that human milk contains diverse communities of bacteria which are distinct from other microbial communities inhabiting the human body. The human milk microbiota which could be source of commensal, mutualistic, and potentially probiotic bacteria to the infant gut microbiota. The World Health Organization (WHO) defines "probiotics" as "living organisms which when administered in adequate amounts confer a health benefit on the host".

Graphic depicting the human skin microbiota, with relative prevalences of various classes of bacteria The human microbiome is the aggregate of all microbiota that reside on or within human tissues and biofluids along with the corresponding anatomical sites in which they reside, including the skin, mammary glands, placenta, seminal fluid, uterus, ovarian follicles, lung, saliva, oral mucosa, conjunctiva, biliary tract, and gastrointestinal tract. Types of human microbiota include bacteria, archaea, fungi, protists and viruses. Though micro-animals can also live on the human body, they are typically excluded from this definition. In the context of genomics, the term human microbiome is sometimes used to refer to the collective genomes of resident microorganisms; however, the term human metagenome has the same meaning.

The syndrome appears to be due to mutations in the gene tetratricopeptide repeat domain 37 (TTC37) which encodes the protein Thespin or the SKIV2L gene. This gene is expressed is in the adrenal gland, amniotic fluid, bladder, blood, bone, bone marrow, brain, cervix, connective tissue, ear, epididymis, eye, heart, intestine, kidney, liver, lung, lymph nodes, mammary glands, mouth, muscle, nerve, oesophagus, ovary, pancreas, pharynx, placenta, prostate, pituitary gland, salivary gland, testis, thyroid, tonsil, thymus, trachea, skin, uterus, spleen, spinal cord, stomach and vascular tissue. It is also expressed in ascites and various embryonic tissues. It is expressed at high level in the intestine, lung, lymph nodes, pituitary and vascular tissues. This gene is also known as KIAA0372, MGC32587 and TPR repeat protein 37.

The Zerasca is a breed of upland sheep from the province of Massa Carrara, in Tuscany in central Italy. It is raised almost exclusively in the comune of Zeri and the neighbouring comune of Pontremoli. In the years after the Second World War, systematic use was made of Massese rams with the aim of improving milk yield; the result was a reduction in resistance to disease and ability to forage on poor terrain, an increase in mammary defects, an increase in colour variability, but little improvement in milk yield. The Zerasca is one of the forty-two autochthonous local sheep breeds of limited distribution for which a herdbook is kept by the Associazione Nazionale della Pastorizia, the Italian national association of sheep-breeders.

Steller's sea cow may have exhibited parental care, and the young were kept at the front of the herd for protection against predators. Steller reported that as a female was being captured, a group of other sea cows attacked the hunting boat by ramming and rocking it, and after the hunt, her mate followed the boat to shore, even after the captured animal had died. Mating season occurred in early spring and gestation took a little over a year, with calves likely delivered in autumn, as Steller observed a greater number of calves in autumn than at any other time of the year. Since female sea cows had only one set of mammary glands, they likely had one calf at a time.

The tyrosine kinase of the ETV6-NTRK3 fusion protein is dysfunctional in that it is continuously active in phosphorylating tyrosine residues on, and thereby continuously stimulating, proteins that promote the growth, survival, and proliferation of their parent cells. In consequence, these cells take on malignant characteristics and are on the pathway of becoming cancerous. Indeed, the ETV6-NTRK3 fusion gene appears to be a critical driver of several types of cancers. It was originally identified in congenital fibrosarcoma and subsequently found in secretory breast cancer (also termed juvenile breast cancer), Mammary analogue secretory carcinoma of salivary glands (also termed MASC or MASCSG), congenital fibrosarcoma, congenital mesoblastic nephroma, rare cases of acute myelogenous leukemia, ALK-negative Inflammatory myofibroblastic tumour, and radiation- induced papillary thyroid carcinoma.

Moreover, GSTK1 gene expression has been seen to increase significantly in correlation to drug resistance in tumor cells such as erythroleukemia and mammary adenocarcinoma suggesting that it, along with GSTP1 and GSTA4, could be responsible for the drug resistance. GSTK1 can also be a potential tool to help investigate cancer. Tyrosine phosphorylated proteins are responsible for many of the cell functions such as the cell’s growth, division, adhesion, and motility. These activities are also very related to cancer and thus studying this protein could allow access to information which could classify tumors for prognosis and prediction. Due to GSTK1’s C-terminal SH2 domain, tyrosine phosphorylated proteins can bind to it and allow for easier detection to which the protein can be studied.

Also, it was observed that lobuloalveolar maturation reverses upon discontinuation of CPA after surgical castration, similarly to the case of mammary gland involution in postpartum women, indicating that continued progestogen treatment is necessary to maintain the histology. It should be noted however that although these findings may have important implications in the context of lactation and breastfeeding, epithelial tissue accounts for approximately only 10% of breast volume with the bulk of the breasts (80–90%) being represented by stromal or adipose tissue, and it is uncertain to what extent, if any, that development of lobuloalveolar structures (a type of epithelial tissue) contributes to breast size or shape. CPA has been found to increase prolactin levels in humans both alone and in combination with an estrogen.

Mental retardation was observed in the children of the atomic-bomb survivors in Japan who were exposed to radiation prenatally at moderate doses (<2 Gy) at 8 to 15 weeks post-conception, but not at earlier or later prenatal times. Radiotherapy for the treatment of several tumors with protons and other charged particle beams provides ancillary data for considering radiation effects for the CNS. NCRP Report No. 153 notes charge particle usage “for treatment of pituitary tumors, hormone-responsive metastatic mammary carcinoma, brain tumors, and intracranial arteriovenous malformations and other cerebrovascular diseases.” In these studies are found associations with neurological complications such as impairments in cognitive functioning, language acquisition, visual spatial ability, and memory and executive functioning, as well as changes in social behaviors.

The survival rates steadily increased from a few hours to several weeks, and one of the dogs that received a heart transplant in 1953 survived for another seven years after the operation. A successful mammary–coronary artery anastomosis was achieved in 1953, after unsuccessful attempts the previous year. Demikhov also developed the principles of myocardial revascularization, which enabled him to perform the first experimental coronary artery bypass operation. The ultimate aim of his research was for organ transplantations to be implemented in clinical practice on humans. The last dog head transplant performed by Vladimir Demikhov on January 13, 1959 in East Germany In February 1954, in arguably his most bizarre experiment, he transplanted a dog's head onto another dog, using vascular connections to the host dog's heart.

Desmond Morris, The Naked Ape: A Zoologist's Study of the Human Animal, page 70, McGraw-Hill, 1967, Evolutionary psychologist David M. Buss explains that female humans evolved to have permanently enlarged mammary glands, unlike all other 222 primates. Functional anatomist Owen Lovejoy ("The origin of man", 1981) suggests, partly based on speculations by Morris, that prominent breasts among female Australopithecines helped attract males and cement the pair-bond necessary for further physical and cultural evolution toward modern humanity.Kathy Dettwyler and Patricia Stuart-Macadam (ed.), Breastfeeding: Biocultural Perspectives, page 179, Taylor & Francis, 2017, Evolutionary psychologists theorize humans' permanently enlarged breasts, in contrast to other primates' breasts—which only become enlarged during ovulation—allowed females to "solicit male attention and investment even when they are not really fertile".

In a showmanship class, conformation is irrelevant since this is not what is being judged. Various "Dairy Goat Scorecards" (milking does) are systems used for judging shows in the US. The American Dairy Goat Association (ADGA) scorecard for an adult doe includes a point system of a hundred total with major categories that include general appearance, the dairy character of a doe (physical traits that aid and increase milk production), body capacity, and specifically for the mammary system. Young stock and bucks are judged by different scorecards which place more emphasis on the other three categories; general appearance, body capacity, and dairy character. The American Goat Society (AGS) has a similar, but not identical scorecard that is used in their shows.

In 2007, the U.S. federal government invited experts to Chapel Hill, North Carolina to perform a scientific assessment of literature on BPA. Thirty-eight experts in fields involved with bisphenol A gathered in Chapel Hill, North Carolina to review several hundred studies on BPA, many conducted by members of the group. At the end of the meeting, the group issued the Chapel Hill Consensus Statement, which stated "BPA at concentrations found in the human body is associated with organizational changes in the prostate, breast, testis, mammary glands, body size, brain structure and chemistry, and behavior of laboratory animals." The Chapel Hill Consensus Statement stated that average BPA levels in people were above those that cause harm to many animals in laboratory experiments.

Excessive fat in the crest of the neck, and areas of the shoulder and flank, are suggestive of EMS EMS horses tend to become obese very easily, depositing fat in the crest, shoulders, loin, above the eyes, around the tail head, and the mammary glands or prepuce, even when the rest of the body appears to be in normal condition. Some horses may have regional adiposity, and others may even appear normal weight, so obesity is not a definitive clinical sign of a horse with EMS. Horses will be insulin resistant (IR), and may have hyperinsulinemia, have abnormal blood glucose, or abnormal insulin responses to glucose. IR predisposes the animal to laminitis, and horses with EMS may have had previous episodes in their history.

Dunn is known as the "First Lady of Cancer Research". According to Harold L. Stewart of the National Cancer Institute, Dunn's important contributions to the field of cancer research include her studies of mammary tumors, reticulum-cell sarcomas, leukemia, plasma-cell tumors, mast-cell tumors, the granular-cell tumors, cervical cancer and the common liver tumor of the mouse. Stewart also mentions Dunn's discoveries the protein-secreting, plasma-cell tumors that originate in the ileocecal region of mice, a finding that initiated a program of animal research that's led to a better understanding of the fatality of human cancer. She developed lines of a transplantable mast-cell tumor of a mouse, now known as "Dunn cells", used widely in laboratory studies.

The emplacement of a breast implant device is performed with five types of surgical incisions: # Inframammary: an incision made below the breast, in the infra-mammary fold (IMF), which affords maximal access for precise dissection and emplacement of the breast implant devices. It is the preferred surgical technique for emplacing silicone-gel implants, because of the longer incisions required; yet, IMF implantation can produce thicker, slightly more visible surgical scars. # Periareolar: an incision made along the areolar periphery (border), which provides an optimal approach when adjustments to the IMF position are required, or when a mastopexy (breast lift) is included to the primary mammoplasty procedure. In the periareolar emplacement method, the incision is around the medial-half (inferior half) of the areola's circumference.

Mammary intercourse involves a man kneeling or sitting on a woman's stomach or chest and placing his erect penis between her breasts, and rubbing or thrusting it there, while the breasts are squeezed around the penile shaft, by either the woman or the man, creating tightness similar to masturbation, and in simulation of penetrative sex. To create a smooth motion, a lubricant, masturbation cream, or saliva may be spread between the breasts or on the penis. In one variant, the woman can tighten her breasts around the penis and move them up and down to bring the man to orgasm. Alternative positions are for the man standing while the woman kneels, or the man laying back with the woman on top.

"John Holmes obituary", The Guardian. Clive Hamilton regarded it as "perhaps the most memorable and unnerving book cover ever created".. Likening the torso to "some fibreglass cast on an industrial production line", Christine Wallace wrote that Holmes' first version was a faceless, breastless, naked woman, "unmistakably Germaine ... hair fashionably afro-frizzed, waist- deep in a pile of stylised breasts, presumably amputated in the creation of a 'female eunuch' based on an assumed equivalence of testicles and mammary glands". The book was reissued in 2001 by Farrar, Straus & Giroux at the instigation of Jennifer Baumgardner, a leading third-wave feminist and editor of the publisher's Feminist Classics series. According to Justyna Wlodarczyk, Greer emerged as "the third wave's favorite second-wave feminist".

Breast changes specifically included enlargement and a sense of fullness, increased sensitivity and pigmentation of the nipples as well as nipple erection, tingling within the breast mammary glandular tissue, and aching and soreness of the breasts. Reproductive tract changes included increased growth, thickness, and differentiation of the endometrium, and reversal of vaginal and cervical atrophy, which were accompanied by increased congestion of the cervix and mucous discharge from the cervix, uterine cramps and needle-like pains, pelvic fullness, a "bearing- down" sensation, and increased vaginal lubrication, as well as uterine bleeding both during treatment and in the days following cessation of injections. Endometrial hyperplasia also occurred with sufficiently high doses of estrone. Clinical research has confirmed the nature of estrone as an inactive prodrug of estradiol.

The breast: cross- section scheme of the mammary gland. In women, the breasts overlie the pectoralis major muscles and usually extend from the level of the second rib to the level of the sixth rib in the front of the human rib cage; thus, the breasts cover much of the chest area and the chest walls. At the front of the chest, the breast tissue can extend from the clavicle (collarbone) to the middle of the sternum (breastbone). At the sides of the chest, the breast tissue can extend into the axilla (armpit), and can reach as far to the back as the latissimus dorsi muscle, extending from the lower back to the humerus bone (the bone of the upper arm).

The α7 subtype of the Nicotinic Acetylcholine is heavily represented in the amygdala (along with the mammary bodies (brain structure), and Ammon's horn. With respect to fMRI data, the drug had a more pronounced effect at the low dose, reportedly on par with Lorazepam, while the high-dose was most similar to Placebo. This should not be at all interpreted that the effects are even remotely related to those of Lorazepam, only that the effect on suppression of this small, particular part of the brain is similar, in simply a measure of metabolic activity. The study included only 24 participants, in 4 arms, so drawing major conclusions from the paper is not wise, but it at least provides additional evidence of possible efficacy.

16α-Hydroxyprogesterone (16α-OHP), also known as 16α-hydroxypregn-4-ene-3,20-dione, is a minor endogenous progestogen steroid hormone and a metabolite of progesterone that is formed in lower amounts than 17α-hydroxyprogesterone (17α-OHP). It occurs in micromolar concentrations and its physiological relevance hence is questionable. However, it may accumulate in target tissues and could have a physiological role in the reproductive system and mammary gland development as well as the cardiovascular and central nervous systems. 16α-OHP is formed from progesterone via 16α-hydroxylation primarily by CYP17A1 and primarily in steroidogenic tissues including the adrenal glands, testes, and ovaries. It is also synthesized from progesterone during pregnancy by hepatic cytochrome P450 enzymes like CYP3A4 and CYP1A1 in the fetal liver as well as placenta.

The arterial blood supply of the breast has medial and lateral vascular components; it is supplied with blood by the internal mammary artery (from the medial aspect), the lateral thoracic artery (from the lateral aspect), and the 3rd, 4th, 5th, 6th, and 7th intercostal perforating arteries. Drainage of venous blood from the breast is by the superficial vein system under the dermis, and by the deep vein system parallel to the artery system. The primary lymph drainage system is the retromammary lymph plexus in the pectoral fascia. Sensation in the breast is established by the peripheral nervous system innervation of the anterior and lateral cutaneous branches of the 4th, 5th, and 6th intercostal nerves, and thoracic spinal nerve 4 (T4 nerve) innervates and supplies sensation to the nipple-areola complex.

It was developed in combination with estradiol enantate as a long-lasting combined injectable contraceptive under the tentative brand names Deladroxate and Droxone by Squibb and was studied in women starting in 1964. Development was discontinued by Squibb in the United States in the late 1960s due to concerns of toxicological findings in animals, including mammary gland tumors in beagle dogs and pituitary hyperplasia in rats, as well as possible accumulation of estradiol enantate in the body with continued use. Subsequent research has shed doubt that these animal findings are applicable to humans and that the dosages required for contraception would pose any risks. Although the medication was not marketed in the United States, its development was continued elsewhere and it went on to be introduced and widely used in Latin America and Spain.

If secondary breast development occurs before the age of 7 or 8 years, the individual may be experiencing either premature thelarche or precocious puberty. Pubertal changes, including breast development, are assessed using the Tanner Scale (Sexual Maturity Rating Scale) where stage 1 represents the lack of breast development, stage 2 is the breast budding or thelarche stage, stages 3 and 4 are continual breast growth and areolar development, and finally, stage 5 signifies completion of development. This system does not use breast size, but instead examines the shape of breasts, nipples, and areolae to determine the progression of growth. The growth and accumulation of adipose tissue in the breasts are induced by estrogen, while the development of mammary glands and areolae are caused by progesterone; both estrogen and progesterone are produced by ovaries.

Glucose-6-phosphate dehydrogenase (G6PD or G6PDH) () is a cytosolic enzyme that catalyzes the chemical reaction : D-glucose 6-phosphate + NADP+ \+ H2O 6-phospho-D-glucono-1,5-lactone + NADPH + H+ This enzyme participates in the pentose phosphate pathway (see image), a metabolic pathway that supplies reducing energy to cells (such as erythrocytes) by maintaining the level of the co-enzyme nicotinamide adenine dinucleotide phosphate (NADPH). The NADPH in turn maintains the level of glutathione in these cells that helps protect the red blood cells against oxidative damage from compounds like hydrogen peroxide. Of greater quantitative importance is the production of NADPH for tissues involved in biosynthesis of fatty acids or isoprenoids, such as the liver, mammary glands, adipose tissue, and the adrenal glands. G6PD reduces NADP+ to NADPH while oxidizing glucose-6-phosphate.

Charles Darwin recognized that mammary glands seemed to have developed specifically from cutaneous glands, and hypothesized that they evolved from glands in brood pouches of fish, where they would provide nourishment for eggs. The latter aspect of his hypothesis has not been confirmed; however, more recently the same mechanism has been postulated for early synapsids. As all mammals lactate, lactation must have evolved before the last common ancestor of all mammals, which places it at a minimum in the Middle or Late Triassic when monotremes diverged from therians. O. T. Oftedal has argued that therapsids evolved a proto-lacteal fluid in order to keep eggs moist, an adaption necessitated due to diapsids parchment shelled eggs which are more vulnerable to evaporation and dehydration than the mineralized eggs produced by some sauropsids.

Whole process is relatively easy to perform and require just changes of given solutions with no need for some customized laboratory equipment. Process of clearing and subsequent imaging is fast (hours to days depending on sample size), especially in comparison with physical sectioning of whole organ, imaging of their parts and reconstruction before subsequent image analysis (that could easily take several weeks). Above that 3DISCO works on many types of tissues (lung, spleen, lymph nodes, mammary gland, tumors). Main drawbacks of this method are partial delipidation of tissue during clearing discriminating use of lipophilic dyes, shrinkage of tissue during clearing, partial degradation of fluorescence, complete degradation of fluorescence during long term storage and toxicity of used reagents (and their potential to damage the microscopy objectives if leak from imaging chamber).

Instead of jumping to the conclusion that a whale is a fish because it has fins and lives in the water (spontaneous concept based on superficial observation), they can learn to apply taxonomic principles of biology to see that below the "surface," whales share the criteria of the class "mammals" (air-breathing vertebrates with hair, mammary glands, etc.). Learning scientific concepts has the effect of restructuring children's way of thinking about the world, and leads to what Piaget called "formal-logical thought" (Inhelder & Piaget 1958). This includes the essential developmental ability to solve problems using abstract, theoretical information that goes beyond mere personal experience (Karpov 2003). For an overview of different types of instruction and their outcomes, from the point of view of neo-Vygotskians, see Arievitch & Stetsenko (2002).

The delivery of fresh feed while the cattle are away for milking stimulates the cattle to fed upon return, potentially reducing the prevalence of mastitis as the sphincters have time to close while standing This makes the pattern of feeding directly after being milked an ideal method of increasing the efficiency of the herd. Cows have a high motivation to lie down so farmers should be conscious of this, not only because they have a high motivation to lie down, but also because lying down can increase milk yield. When the lactating dairy cow lies down, blood flow is increased to the mammary gland which in return results in a higher milk yield. To ensure that the dairy cows lie down as much as needed, the stalls must be comfortable.

Mammary glands discharge the fat (as cream fat droplets) into the milk that they produce under the influence of the anterior pituitary hormone prolactin. All cells in the body need to manufacture and maintain their membranes and the membranes of their organelles. Whether they rely for this entirely on free fatty acids absorbed from the blood, or are able to synthesize their own fatty acids from the blood glucose, is not known. The cells of the central nervous system will almost certainly have the capability of manufacturing their own fatty acids, as these molecules cannot reach them through the blood brain barrier, while, on the other hand, no cell in the body can manufacture the required essential fatty acids which have to be obtained from the diet and delivered to each cell via the blood.

Mammoplasia may be due to breast engorgement, which is temporary enlargement of the breasts caused by the production and storage of breast milk in association with lactation and/or galactorrhea (excessive or inappropriate production of milk). Mastodynia (breast tenderness/pain) frequently co-occurs with mammoplasia. During the luteal phase (latter half) of the menstrual cycle, due to increased mammary blood flow and/or premenstrual fluid retention caused by high circulating concentrations of estrogen and/or progesterone, the breasts temporarily increase in size, and this is experienced by women as fullness, heaviness, swollenness, and a tingling sensation. Mammoplasia can be an effect or side effect of various drugs, including estrogens, antiandrogens such as spironolactone, cyproterone acetate, bicalutamide, and finasteride, growth hormone, and drugs that elevate prolactin levels such as D2 receptor antagonists like antipsychotics (e.g.

Like other mammals, monotremes are endothermic with a high metabolic rate (though not as high as other mammals; see below); have hair on their bodies; produce milk through mammary glands to feed their young; have a single bone in their lower jaw; and have three middle-ear bones. In common with reptiles and marsupials, monotremes lack the connective structure (corpus callosum) which in placental mammals is the primary communication route between the right and left brain hemispheres. The anterior commissure does provide an alternate communication route between the two hemispheres, though, and in monotremes and marsupials it carries all the commissural fibers arising from the neocortex, whereas in placental mammals the anterior commissure carries only some of these fibers. Platypus Long-beaked echidna Diagram of a Monotreme Egg.

Hybrid coronary revascularization is a common procedure that takes advantage of coronary stenting in combination with CABG. Hybrid coronary bypass is a relatively new procedure and alternative to traditional bypass surgery that is defined by the performance of coronary bypass surgery and coronary stenting of different areas of a patient's heart. MICS CABG allows utilization of the left internal mammary artery (IMA; aka Left internal thoracic artery, Left ITA) to bypass the left anterior descending artery (LAD), which is termed as Left IMA-LAD, as a preferable anastamosis whenever indicated and technically feasible (Loop et al.) and has been proven to benefit in event free survival (Acinapura et al.). The other one or two arteries will be stented, when appropriate, allowing cardiologists and cardiothoracic surgeons to work together.

PELP1 functions as a coactivator of several NRs and regulates genes involved in proliferation and cancer progression. PELP1 enhances transcription functions of ESR1, ESR2, AR, GR, E2F and STAT3. PELP1 participates in activation of ESR1 extra-nuclear actions by coupling ESR1 with Src kinase PI3K STAT3 ILK1 and mTOR PELP1 participates in E2-mediated cell proliferation and is a substrate of CDK4/cyclin D1, CDK2/cyclin E and CDK2/cyclin A complexes. Studies using TG mice model suggested the existence of an autocrine loop involving the CDK–cyclin D1–PELP1 axis in promoting mammary tumorigenesis PELP1 has a histone binding domain; functions as a reader of histone modifications, interacts with epigenetic modifiers such as HDAC2, KDM1, PRMT6, CARM1; and facilitates activation of genes involved in proliferation and cancer progression.

Parton has turned down several offers to pose nude for Playboy magazine, but did appear on the cover of the October 1978 issue wearing a Playboy bunny outfit, complete with ears (the issue featured Lawrence Grobel's extensive and candid interview with Parton, representing one of her earliest high-profile interviews with the mainstream press). The association of breasts with Parton's public image is illustrated in the naming of Dolly the sheep after her, since the sheep was cloned from a cell taken from an adult ewe's mammary gland. In Mobile, Alabama, the General W.K. Wilson Jr. Bridge is commonly called "the Dolly Parton Bridge" due to its arches resembling her bust. The Hernando de Soto Bridge over the Mississippi River at Memphis is also sometimes called this for the same reason.

The arterial blood supply of the breast has medial and lateral vascular components; it is supplied with blood by the internal mammary artery (from the medial aspect), the lateral thoracic artery (from the lateral aspect), and the 3rd, 4th, 5th, 6th, and 7th intercostal perforating arteries. Drainage of venous blood from the breast is by the superficial vein system under the dermis, and by the deep vein system parallel to the artery system. The primary lymph drainage system is the retromammary lymph plexus in the pectoral fascia. Sensation in the breast is established by the peripheral nervous system innervation of the anterior and lateral cutaneous branches of the 4th, 5th, and 6th intercostal nerves, and thoracic spinal nerve 4 (T4 nerve) innervates and supplies sensation to the NAC.

Several kinds of viruses with oncogenic potential are suspected to play a role or cause breast cancer. Among the three most commonly studied are the human papilloma virus (HPV), mouse mammary tumour virus (MMTV) and the Epstein-Barr virus (EBV). A study published in 2011, reviewing 85 original molecular research investigations on the presence of one or more of these three viruses found that only seven of the studies convincingly demonstrated the presence of an oncogenic virus biomarker, while twenty-five of the studies were able to show the absence of the virus studied, and the remaining studies were excluded due to shortcomings. Thus, the data from these investigations do not justify a conclusion as to whether HPV, MMTV, or EBV play a causal role in human breast cancer development.

Pulmonary alveolar microlithiasis (PAM) is a rare, inherited disorder of lung phosphate balance that is associated with small stone formation in the airspaces of the lung. Mutations in the gene SLC34A2 result in loss of a key sodium, phosphate co-transporter (called Npt2b), known to be expressed in distal alveolar type II cells, as well as in the mammary gland, and to a lesser extent in intestine, kidney, skin, prostate and testes. As the disease progresses, the lung fields become progressively more dense (white) on the chest xray, and low oxygen level, lung inflammation and fibrosis, elevated pressures in the lung blood vessels, and respiratory failure ensue, usually in middle age. The clinical course of PAM can be highly variable, with some patients remaining asymptomatic for decades, and others progressing more rapidly.

The β subunits have tyrosine kinase enzyme activity which is triggered by the insulin binding. This activity provokes the autophosphorylation of the β subunits and subsequently the phosphorylation of proteins inside the cell known as insulin receptor substrates (IRS). The phosphorylation of the IRS activates a signal transduction cascade that leads to the activation of other kinases as well as transcription factors that mediate the intracellular effects of insulin. The cascade that leads to the insertion of GLUT4 glucose transporters into the cell membranes of muscle and fat cells, and to the synthesis of glycogen in liver and muscle tissue, as well as the conversion of glucose into triglycerides in liver, adipose, and lactating mammary gland tissue, operates via the activation, by IRS-1, of phosphoinositol 3 kinase (PI3K).

Ethandrostate, also known as ethinylandrostenediol 3β-cyclohexanepropionate, is a synthetic steroidal estrogen and ester of ethinylandrostenediol (17α-ethynyl-5-androstenediol) which was developed and studied in people with certain cancers like breast cancer and prostate cancer in the 1950s but was never marketed. Although far less potent by weight than estradiol or estrone, ethandrostate produces estrogenic effects in the vagina, uterus, and mammary glands as well as antigonadotropic and secondary antiandrogenic effects like testicular and prostate atrophy in both animals and humans. Ethandrostate was assessed in humans as an aqueous suspension by intramuscular injection at doses of 100 to 200 mg/day or 100 mg three times per week and by mouth at a dose of 25 mg four times per day. It shows much greater antigonadotropic potency relative to general estrogenic potency in animals when compared with other estrogens.

In the European Union, "milk" by law refers exclusively to "the normal mammary secretion obtained from one or more milkings without either addition thereto or extraction therefrom".. Only cow's milk is allowed to be named "milk" on packaging, and any other milks must state the name of the respective animal: for example, "goat milk" or "sheep milk". The naming of soy drink as soy milk became subject of a 2017 court case before the Court of Justice of the European Union after a German consumer protection group filed an unfair competition complaint about a company describing its soya and tofu products as 'milk' or 'cheese'. The Court of Justice ruled that such designations cannot be legally used for purely plant-based products and that additions indicating the plant origin of the products (soy milk) does not influence that prohibition.

Bisphenol A chemical structure Bisphenol A is commonly found in plastic bottles, plastic food containers, dental materials, and the linings of metal food and infant formula cans. Another exposure comes from receipt paper commonly used at grocery stores and restaurants, because today the paper is commonly coated with a BPA containing clay for printing purposes. BPA is a known endocrine disruptor, and numerous studies have found that laboratory animals exposed to low levels of it have elevated rates of diabetes, mammary and prostate cancers, decreased sperm count, reproductive problems, early puberty, obesity, and neurological problems. Early developmental stages appear to be the period of greatest sensitivity to its effects, and some studies have linked prenatal exposure to later physical and neurological difficulties. Draft Screening Assessment for The Challenge Phenol, 4,4′-(1-methylethylidene)bis- (Bisphenol A) Chemical Abstracts Service Registry Number 80-05-7.

Furylfuramide (also known as AF-2) is a synthetic nitrofuran derivative which was widely used as a food preservative in Japan since at least 1965, but withdrawn from the market in 1974 when it was observed to be mutagenic to bacteria in vitro and thus suspected of carcinogenicity. This was confirmed later when animal testing found it to cause benign and malignant tumors in the mammary glands, stomachs, esophagi, and lungs of rodents of both sexes, although insufficient evidence exists in human exposure. This successful use of bacterial mutagenicity as a screen for carcinogenicity confirmed the use of this methodology as a rapid and efficient test, in comparison to animal testing alone, and led to its further development. The availability of such simpler tests in turn gave rise to greater government oversight and testing of compounds to which the public would be exposed.

Western pygmy possums can breed throughout the year, although they do so more commonly in the spring, and give birth to litters of four to six young. The mother often carries more than six embryos at a time in her womb, but because she has only six teats, and marsupial young remain attached to an individual teat for much of their early lives, six is the maximum number she is able to rear. Unusually, however, the mother may give birth just two days after weaning a previous litter, with her teats dramatically changing in size to accommodate the smaller young, and the mammary glands reverting to production of colostrum. The young are still blind when they leave the pouch at around 25 days of age; they initially remain within the nest, and are fully weaned at around 50 days.

The inhibitory activity of cerivastatin was compared to that of other statins, specifically lovastatin, simvastatin and pravastatin. This comparison was made by determining the IC50 values of each compound. These values were 77 nM, 66 nM and 176 nM for these statins, respectively, while the value for cerivastatin was found to be 1.1 nM. Using Dixon plots, the inhibitory constant of cerivastatin was found to be 1.3 x 10-9 M, which is over 100 times lower than the inhibitory constant of lovastatin, known to be 150 x 10-9 M. To compare cerivastatin activity to that of other statins, its IC25 value was also determined for various types of human smooth muscle cells: cells from the left internal mammary artery (HSMC), cornea fibroblasts (HCF), myoblasts from striated muscle (HM) and umbilical vein endothelial cells (HUVEC).

From 2009 to 2011, he served on the board of directors of Marriott International, founded by his namesake J. Willard Marriott. He had previously served on it from 1993 to 2002. Romney signing copies of his new book No Apology: The Case for American Greatness for service members at Marine Corps Air Station Miramar in March 2010 In 2009, the Romneys sold their primary residence in Belmont and their ski chalet in Utah, leaving them an estate along Lake Winnipesaukee in Wolfeboro, New Hampshire, and an oceanfront home in the La Jolla district of San Diego, California, which they had purchased the year before. The La Jolla home proved beneficial in location and climate for Ann Romney's multiple sclerosis therapies and for recovering from her late 2008 diagnosis of mammary ductal carcinoma in situ and subsequent lumpectomy.

In 2002 Hayes published findings that he says replicate what he found while he was working for EcoRisk, that developing male African clawed frogs and leopard frogs exhibited female characteristics after exposure to atrazine, first in the Proceedings of the National Academy of Sciences (PNAS) and then in Nature. In 2007, Hayes was a co-author on a paper that detailed atrazine inducing mammary and prostate cancer in laboratory rodents and highlighted atrazine as a potential cause of reproductive cancers in humans. In 2007, Hayes presented results of his studies to the U.S. National Institute of Environmental Health Sciences showing chemical castration in frogs; individuals of both sexes had developed bisexual reproductive organs. In 2010, Hayes published research in PNAS describing laboratory work showing how exposure to atrazine turned male tadpoles into females with impaired fertility.

ABCC11 is a gene encoding an apical ATP-driven efflux transporter that has been found to transport a variety of lipophilic anions including cyclic nucleotides, estradiol glucuronide, steroid sulfates such as DHEA-S, and monoanionic bile acids. It is expressed and localized in apocrine glands, including in the axilla, the ceruminous glands in the auditory canal, and in the mammary gland. A single-nucleotide polymorphism (SNP) 538G→A in ABCC11 that leads to a G180R substitution in the encoded protein has been found to result in loss-of-function via affecting N-linked glycosylation and in turn causing proteasomal degradation of the protein. This polymorphism has been found to be responsible for the dry and white earwax phenotype, and is considered to be unique as it has been described as the only human SNP that has been found to determine a visible genetic trait.

Despite these developments, open presentation of cleavage was mostly limited to well-endowed female actors like Lana Turner, Marilyn Monroe (who was accused of revealing America's "mammary madness" by journalist Marjorie RosenRachel Moseley, Fashioning Film Stars: Dress, Culture, Identity, page 58, Bloomsbury Academic, 2005, ), Rita Hayworth, Jane Russell, Brigitte Bardot, Jayne Mansfield and Sophia Loren, who were as celebrated for their cleavage as for their beauty. While these movie stars significantly influenced the appearance of women's busts in this decade, the stylish 1950s sweaters were a safer substitute for many women.Don J. Dampier, Finding the Fifties, page 238, DJ Discovery Press, 2005, Lingerie manufacturer Berlei launched the "Hollywood Maxwell" brassière, claiming it to be a "favourite of film stars". Modern augmentation mammaplasty began when Thomas Cronin and Frank Gerow developed the first silicone gel-filled breast prosthesis with Dow Corning Corporation, and the first implanting operation took place the following year.

The anterior divisions of the second, third, fourth, fifth, and sixth thoracic nerves, and the small branch from the first thoracic, are confined to the walls of the thorax, and are named thoracic intercostal nerves. They pass forward in the intercostal spaces below the intercostal vessels. At the back of the chest they lie between the pleura and the posterior intercostal membranes, but soon they run between the internal intercostals and the innermost intercostals then anteriorly they lie between the pleura and the internal intercostals. Near the sternum, they cross in front of the internal mammary artery and transversus thoracis muscle, pierce the intercostales interni, the anterior intercostal membranes, and pectoralis major, and supply the integument of the front of the thorax and over the mamma, forming the anterior cutaneous branches of the thorax; the branch from the second nerve unites with the anterior supraclavicular nerves of the cervical plexus.

Chloroethynylnorgestrel (developmental code name WY-4355) is a steroidal progestin of the 19-nortestosterone group related to norgestrel that was investigated as an oral contraceptive in the 1970s but was never marketed. In combination with mestranol, similarly to ethynerone and anagestone acetate (and certain other progestogens, including progesterone and several other 17α-hydroxyprogesterone derivatives), chloroethynylnorgestrel was found to produce striking mammary tumors in beagle dogs after administration at very high dosages (10- to 25-fold human clinical dosages) for prolonged periods of time. This resulted in the discontinuation of its development, along with that of ethynerone and anagestone acetate, as well as the removal of several progestins, including chlormadinone acetate, medroxyprogesterone acetate, and megestrol acetate, from various markets as contraceptives (although medroxyprogesterone acetate has since been reintroduced). Subsequent research revealed that the risk is species-dependent and unique to canines and that there is no similar risk for humans.

The treatment of ETV6 gene-associated solid tumors has not advanced as far as that for ETV6 gene-associated hematological malignancies. It is proposed that tyrosine kinase inhibitors with specificity for NTRK3's tyrosine kinase activity in ETV6-NTRK3 gene-associated solid tumors may be of therapeutic usefulness. Entrectinib, a pan-NTRK as well as an ALK and ROS1 tyrosine kinase inhibitor has been found useful in treating a single patient with ETV6-NRTK3 fusion gene-associated mammary analogue secretory carcinoma and lends support to the clinical development of NTRK3-directed tyrosine kinase inhibitors to treat ETV6-NTRK3 fusion protein associated malignancies. Three clinical trials are in the recruitment phase for determining the efficacy of treating a wide range of solid tumors associated with mutated, overactive tyrosine kinase proteins, including the ETV6-TRK3 protein, with larotrectinib, a non-selective inhibitor of NTRK1, NTRK2, and NTRK3 tyrosine kinases.

Ejaculation onto a woman's chest after mammary intercourse Although earlier pornographic films occasionally contained footage of ejaculation, it was not until the advent of hard-core pornography in the 1970s that the stereotypical cum shot scene became a standard feature—displaying ejaculation with maximum visibility. The 1972 film Behind the Green Door featured a seven-minute-long sequence described by Linda Williams, professor of film studies, as "optically printed, psychedelically colored doublings of the ejaculating penis". Steven Ziplow's The Film Maker's Guide to Pornography (1977) states: Cum shot scenes may involve the female actor calling for the shot to be directed at some specific part of her body. Cultural analysis researcher Murat Aydemir considers this one of the three quintessential aspects of the cum shot scene, alongside the emphasis on visible ejaculation and the timing of the cum shot, which usually concludes a hard-core scene.

Prevention of mouse mammary carcinoma with vaccines against HER2/neu led to the development of the oncoantigen concept, thanks to the addiction of transgenic tumors to HER-2 expression and to the fundamental role of vaccine-induced anti-HER-2 antibodies in the arrest of tumor development. Oncoantigens are thought to be the ideal target for immunologic prevention of cancer in individuals at risk, because the continuous generation of precancerous or early cancerous cells might easily lead over time to the emergence of antigen- or MHC-loss escape variants. As escape variants are a major cause of failure also in cancer immunotherapy, it is likely that targeting oncoantigens with vaccines or antibodies will have a stronger clinical impact than attempts at targeting other tumor antigens. The problem so far in using vaccines in oncoantigen research is that the vaccines are typically not long lasting.

TP63 mutations underlie several malformation syndromes that include cleft lip and/or palate as a hallmark feature. Mutations in the TP63 gene are associated with ectrodactyly-ectodermal dysplasia-cleft syndrome in which a midline cleft lip is a common feature, cleft lip/palate syndrome 3 (EEC3); ectrodactyly (also known as split-hand/foot malformation 4 (SHFM4)); ankyloblepharon-ectodermal dysplasia-cleft lip/palate (AEC) or Hay–Wells syndrome in which a midline cleft lip is also a common feature, Acro–dermato–ungual–lacrimal–tooth syndrome (ADULT); limb-mammary syndrome; Rap-Hodgkin syndrome (RHS); and orofacial cleft 8. p63 staining on prostate cancer tissue using antibody clone IHC063 Both cleft lip with or without a cleft palate and cleft palate only features have been seen to segregate within the same family with a TP63 mutation. Recently, induced pluripotent stem cells have been produced from patients affected by EEC syndromes by cell reprogramming.

No carcinogenic effects were found with brimonidine tartrate in mice or rats. With timolol maleate, 300 mg/kg/day in rats (equivalent to about 42,000 times systemic exposure following the maximum recommended ocular dose in human [MRHOD]) was associated with significantly increased incidence of adrenal pheochromocytomas in a two-year study; in a lifetime study in mice, 500 mg/kg/day (equivalent to about 71,000 times systemic exposure following the MRHOD) but not 5 or 50 mg/kg/day (about 700 or 7,000 times systemic exposure following the MRHOD) of timolol maleate was associated with significantly increased incidence of benign and malignant pulmonary tumors, benign uterine polyps and mammary adenocarcinomas. Neither brimonidine tartrate nor timolol maleate was mutagenic in in vitro and in vivo studies. Reproduction and fertility studies in rats did not reveal any adverse effects on male or female fertility with brimonidine tartrate or timolol maleate.

Tarlochan Singh Kler is an Indian interventional cardiologist, medical administrator, writer, Chairman at Pushpawati Singhania Hospital & Research Institute and (former Director of Cardiac Sciences at Fortis Escorts Heart Institute). Born in Amargarh in the Indian state of Punjab, he graduated in medicine from Punjabi University in 1976, secured his MD in general medicine from Postgraduate Institute of Medical Education and Research (PGIMER) in 1980 and followed it up with the degree of DM in cardiology from the same institution in 1983. He succeeded Naresh Trehan as the executive director of Fortis Heart Institute and Research Centre before becoming its director. He has written several articles on interventional cardiology; Persistent left superior vena cava opening directly into right atrium and mistaken for coronary sinus during biventricular pacemaker implantation, Mammary coronary artery anastomosis without cardiopulmonary bypass through minithoracotomy: one year clinical experience, and Ventricular Fibrillation in the EP Lab.

NASA initially funded the company that produces AESOP, Computer Motion, due to its goal to create a robotic arm that can be used in space, but this project ended up becoming a camera used in laparoscopic procedures. Voice control was then added in 1996 with the AESOP 2000 and seven degrees of freedom to mimic a human hand was added in 1998 with the AESOP 3000. ZEUS was introduced commercially in 1998, and was started the idea of telerobotics or telepresence surgery where the surgeon is at a distance from the robot on a console and operates on the patient. Examples of using ZEUS include a fallopian tube reconnection in July 1998, a beating heart coronary artery bypass graft in October 1999, and the Lindbergh Operation, which was a cholecystectomy performed remotely in September 2001. In 2003, ZEUS made its most prominent mark in cardiac surgery after successfully harvesting the left internal mammary arteries in 19 patients, all of which had very successful clinical outcomes.

Because cancers associated with the expression of the ETV6-NTRK3 fusion protein are known or suspected of being a direct consequence of overly active ETV6-NTRK3's tyrosine kinase, it has been proposed that tyrosine kinase inhibitors with specificity for NTRK3 may be of therapeutic usefulness in these cancers. Entrectinib is a pan-NTRK as well as an ALK and ROS1 tyrosine kinase inhibitor has been found useful in treating a single patient with ETV6-NRTK3 fusion gene-associated mammary analogue secretory carcinoma and has lend support to the clinical development of NTRK3-directed tyrosine kinase inhibitors to treat ETV6-NTRK3 fusion protein associated malignancies. Three clinical trials are in the recruitment phase for determining the efficacy of treating a wide range of solid tumors associated with mutated overactive tyrosine kinase proteins, including the ETV6-TRK3 protein, with larotrectinib, a non-selective inhibitor of NTRK1, NTRK2, and NTRK3 tyrosine kinases. Larotrectinib was approved by the FDA on November 26, 2018.

At least one way that they do this is by reducing the expression of the estrogen receptor in breast tissue. In the absence of androgenic activity, such as in women with complete androgen insensitivity syndrome (CAIS), modest levels of estrogen (50 pg/mL) are capable of mediating significant breast development, with CAIS women showing breast volumes that are even above-average. The combination of much higher levels of androgens (about 10-fold higher) and much lower levels of estrogen (about 10-fold less), due to the ovaries in females producing high amounts of estrogens but low amounts of androgens and the testes in males producing high amounts of androgens but low amounts of estrogens, are why males generally do not grow prominent or well-developed breasts relative to females. Calcitriol, the hormonally active form of vitamin D, acting through the vitamin D receptor (VDR), has, like the androgens, been reported to be a negative regulator of mammary gland development in mice, for instance, during puberty.

Estrogen, progesterone, and prolactin, as well as GH/IGF-1, produce their effects on breast development by modulating the local expression in breast tissue of an assortment of autocrine and paracrine growth factors, including IGF-1, IGF-2, amphiregulin, EGF, FGF, hepatocyte growth factor (HGF), tumor necrosis factor α (TNF-α), tumor necrosis factor β (TNF-β), transforming growth factor α (TGF-α), transforming growth factor β (TGF-β), heregulin, Wnt, RANKL, and leukemia inhibitory factor (LIF). These factors regulate cellular growth, proliferation, and differentiation via activation of intracellular signaling cascades that control cell function, such as Erk, Akt, JNK, and Jak/Stat. Based on research with epidermal growth factor receptor (EGFR) knockout mice, the EGFR, which is the molecular target of EGF, TGF-α, amphiregulin, and heregulin, has, similarly to the insulin-like growth factor-1 receptor (IGF-1R), been found to be essential for mammary gland development. Estrogen and progesterone mediate ductal development mainly through induction of amphiregulin expression, and thus downstream EGFR activation.

In contrast to p,p'-DDD, which has direct cytotoxic effects on the adrenal glands via an unknown mechanism, amphenone B does not have cytotoxic effects, and instead causes adrenal and thyroid gland hypertrophy due to respective inhibition of corticosteroid and thyroxine biosynthesis, subsequent loss of negative feedback on the hypothalamic-pituitary-adrenal and hypothalamic-pituitary- thyroid axes, and consequent hypersecretion of adrenocorticotropic hormone (ACTH) and thyroid-stimulating hormone (TSH) from the pituitary gland. Amphenone B has also been found to produce progesterone-like progestogenic effects, including uterine hypertrophy and mammary lobuloalveolar development. These effects occurred even in animals that had been ovariectomized and hypophysectomized, suggesting that amphenone B might be acting directly on the target organs. However, it was found that adrenalectomy abolished the progesterone-like effects of amphenone B on the uterus, whereas those of progesterone were retained in the same experimental conditions, supporting the notion that amphenone B was not actually acting directly on the uterus.

T cells must reproduce after arriving at the tumor site to further increase their numbers, survive the TME's hostile elements and migrate through the stroma to the cancer cells. The TME obstructs all three activities. The draining lymph nodes are the likely location for T cell clonal reproduction, although this also occurs within the tumor. Preclinical models suggest that the TME is the major site of cancer-specific T cell cloning and that the CD8+ T cell replicative response there is orchestrated by the CD103+, Baft3-dependent DC, which can efficiently cross-present cancer cell antigens, suggesting that therapeutic interventions that enhance CD103+ contribute to tumor control. Among such strategies are antibodies to the interleukin-10 receptor (IL10R). In a mammary carcinoma mouse model it neutralized the effects of TAM-produced IL10, relieved the suppression of IL12 production by intratumoral DCs and improved the CD8+ T cell–dependent antitumor effects of chemotherapy.

However, in most endemic areas, adult women are the most severely affected by anemia, mainly because they have much higher physiological needs for iron (menstruation, repeated pregnancy).An interesting consequence of this in the case of Ancylostoma duodenale infection is translactational transmission of infection: the skin-invasive larvae of this species do not all immediately pass through the lungs and on into the gut, but spread around the body via the circulation, to become dormant inside muscle fibers. In a pregnant woman, after childbirth some or all of these larvae are stimulated to re-enter the circulation (presumably by sudden hormonal changes), then to pass into the mammary glands, so that the newborn baby can receive a large dose of infective larvae through its mother's milk. This accounts for otherwise inexplicable cases of very heavy, even fatal, hookworm infections in children a month or so of age, in places such as China, India and northern Australia.

The usual mastopexy patient is the woman who desires the restoration of her bust (elevation, size, and contour), because of the post-partum volume losses of fat and milk-gland tissues, and the occurrence of breast ptosis. The clinical indications presented by the woman—the degrees of laxness of the suspensory Cooper's ligaments; and of the breast skin-envelope (mild, moderate, severe, and pseudo ptosis)—determine the applicable restorative surgical approach for lifting the breasts. Grade I (mild) breast ptosis can be corrected solely with breast augmentation, surgical and non-surgical. Severe breast ptosis can be corrected with breast-lift techniques, such as the Anchor pattern, the Inverted-T incision, and the Lollipop pattern, which are performed with circumvertical and horizontal surgical incisions; which produce a periareolar scar, at the periphery (edge) of the nipple-areola complex (NAC), and a vertical scar, descending from the lower margin of the NAC to the horizontal scar in the infra-mammary fold (IMF), where the breast meets the chest; such surgical scars are the aesthetic disadvantages of mastopexy.

MTA1 modulates the expression of target genes due to its ability to act as a corepressor or coactivator. MTA1 targets and/or effector pathways regulate pathways with cellular functions in both normal and cancer cells. Physiological functions of MTA1 include: its role in the brain due to MTA1 interactions with DJ1 and endophilin-3; regulation of Rhodopsin expression in the murine eye; modifier of circadian rhythm due to MTA1 interactions with the CLOCK-BMAL1 complex and stimulation of Cry-transcription; in heart development due to MTA1-FOG2 interaction; in mammary gland development as MTA1 depletion leads to ductal hypobranching, in spermatogenesis; in immunomodulation due to differential effects on the expression of cytokines in the resting and activated macrophage; in liver regeneration following hepatic injury; differentiation of mesenchymal stem cells into osteogenic axis; and a component of DNA-damage response. In cancer cells, MTA1 and its downstream effectors regulate genes and/or pathways with roles in transformation, invasion, survival, angiogenesis, epithelial-to-mesenchymal transition, metastasis, DNA damage response, and hormone-independence of breast cancer.

Immediately after graduation in 1941, McClymont was appointed as a specialist in animal nutrition at the New South Wales Department of Agriculture. In that position, he was responsible for all extension, advisory work, and policy advice on animal nutrition for the state government. In one instance during the war, McClymont had to respond to a swine influenza outbreak caused by pig meat imported by American troops stationed in Australia. While participating in an operation to kill and burn potentially infected suidae in a local piggery, he met his future wife, Vivienne Pecover, sister of the farmer whose pigs were being slaughtered. The two married in 1946.Ryan (1996), p. 15 From 1947 to 1949, under a Walter and Eliza Hall Veterinary Research Fellowship, he attended the University of Cambridge from which he earned a doctor of philosophy.Leng and McClymont (2000) His thesis, called Interrelationships between the digestive and mammary physiology of ruminants, was based on research he had conducted in 1947 in which he discovered that green oat consumption by dairy cows produced milk with less butterfat.

They defined for the first time the quantitative dynamics of tumor initiation at the single cell level from the activation of the oncogene to the development of invasive tumors and demonstrated that the capacity of oncogene expressing cells to induce tumor formation depends on the specific clonal dynamics of the oncogene targeted stem cells at the origin of the cancer. The Blanpain lab has been studying the different cell states of the epithelio-mesenchymental transition that invasive tumor undergo: they demonstrated that different epidermal stem cells are responsible for invasive squamous cell carcinoma, that hair follicle lineage is primed to undergo EMT during tumorigenesis. They characterized the different transitional states of tumor cells during EMT, in particular they showed that specific subpopulations have higher potential to undergo EMT and metastasize. By screening a large panel of cell surface markers, Blanpain and colleagues identified the existence of different tumor subpopulations in skin and mammary primary tumors associated with different stages of EMT from epithelial to completely mesenchymal states passing through intermediate hybrid states.

His most seminal research accomplishments include the direct visualization in living cells of the recruitment of factors involved in gene expression to active genes; the development of a biochemical fractionation approach to purify a sub-nuclear domain (nuclear speckles) and characterize its protein constituents; the development of a live cell imaging system to visualize a stably integrated genetic locus and follow in real-time its mRNA and protein products; the elucidation of a rapid-response mechanism of regulating gene expression through RNA nuclear retention; identification of a mechanism by which a single genetic locus can produce a long nuclear retained non-coding RNA and a small cytoplasmic tRNA-like transcript, the identification and characterization of a long nuclear retained non-coding RNA that is involved in organizing a sub- nuclear organelle (paraspeckles), and determining that knockout or knockdown of the lncRNA Malat1 results in the differentiation of mammary tumors and a significant reduction in metastasis. In addition, Spector has co-edited numerous microscopy techniques manuals (i.e. Basic Methods in Microscopy, Live Cell Imaging: A Laboratory Manual), and a treatise of The Nucleus, that are used in laboratories throughout the world.

In addition to its role in mediating ductal development, estrogen causes stromal tissue to grow and adipose (fat) tissue to accumulate, as well as the nipple- areolar complex to increase in size. Progesterone, in conjunction with GH/IGF-1 similarly to estrogen, affects the development of the breasts during puberty and thereafter as well. To a lesser extent than estrogen, progesterone contributes to ductal development at this time, as evidenced by the findings that progesterone receptor (PR) knockout mice or mice treated with the PR antagonist mifepristone show delayed (albeit eventually normal, due to estrogen acting on its own) ductal growth during puberty and by the fact that progesterone has been found to induce ductal growth on its own in the mouse mammary gland mainly via the induction of the expression of amphiregulin, the same growth factor that estrogen primarily induces to mediate its actions on ductal development. In addition, progesterone produces modest lobuloalveolar development (alveolar bud formation or ductal sidebranching) starting at puberty, specifically through activation of PRB (and notably not PRA), with growth and regression of the alveoli occurring to some degree with each menstrual cycle.

The G protein-coupled receptor, GPR31, cloned from PC3 human prostate cancer cell line is a high affinity (Kd=4.8 nM) receptor for 12(S)-HETE; GPR31 does not bind 12(R)-HETE and has relatively little affinity for 5(S)-HETE or 15(S)-HETE. GPR31 mRNA is expressed at low levels in several human cell lines including K562 cells (human myelogenous leukemia cell line), Jurkat cells, (T lymphocyte cell line), Hut78 cells (T cell lymphoma cell line), HEK 293 cells (primary embryonic kidney cell line), MCF7 cells (mammary adenocarcinoma cell line), and EJ cells (bladder carcinoma cell line). This mRNA appears to be more highly expressed in PC3 and DU145 prostate cancer cell lines as well as in human umbilical vein endothelial cells (HUVEC), human umbilical vein endothelial cells (HUVEC), human brain microvascular endothelial cells (HBMEC), and human pulmonary aortic endothelial cells (HPAC). In PC-3 prostate cancer cells, GPR31 receptor mediates the action of 12(S)-HETE in activating the Mitogen-activated protein kinase kinase/Extracellular signal-regulated kinases-1/2 pathway and NFκB pathway that lead to cell growth and other functions.

The latter may have been the primitive form of egg care in synapsids rather than simply burying the eggs, and the constraint on the parent's mobility would have been solved by having the eggs "parked" in nests during foraging or other activities and periodically be hydrated, allowing higher clutch sizes than could fit inside a pouch (or pouches) at once, and large eggs, which would be cumbersome to carry in a pouch, would be easier to care for. The basis of Oftedal's speculation is the fact that many species of anurans can carry eggs or tadpoles attached to the skin, or embedded within cutaneous "pouches" and how most salamanders curl around their eggs to keep them moist, both groups also having glandular skin. The glands involved in this mechanism would later evolve into true mammary glands with multiple modes of secretion in association with hair follicles. Comparative analyses of the evolutionary origin of milk constituents support a scenario in which the secretions from these glands evolved into a complex, nutrient-rich milk long before true mammals arose (with some of the constituents possibly predating the split between the synapsid and sauropsid lines).

Performing a BLASTn query search with the ESTs (expressed sequence tags) database for the cDNA clones derived from the probes, revealed that 53% of related transcripts were found in placental cells. A southern blot using hybridization of gag, pro, env derived probes revealed a complex distribution of HERV-Ws in the human haploid genome with 70 gag, 100 pro, and 30 env regions. With in vitro transcription techniques three suggested ORFs on chromosome 3 (gag), 6 (pro) and 7 (env) were detected and further analyzed revealing that the ORF on chromosome 7q21.2 uniquely encoded a glycosylated Env protein. Performing RealTime RT-PCR on adrenal gland, bone marrow, cerebellum, whole brain, fetal brain, fetal liver, heart, kidney, liver, lung, placenta, prostate, salivary gland, skeletal muscle, spinal cord, testis, thymus, thyroid gland, trachea, and uterus cells revealed 22 complete HERV-W families on chromosomes 1–3, 5–8, 10–12, 15, 19 and X. In silico expression data revealed that these HERV-W elements are randomly expressed in various tissues (brain, mammary gland, cerebrum, skin, testis, eye, embroyonic tissue, pancreatic islet, pineal gland, endocrine, retina, adipose tissue, placenta and muscle).

It is recorded that antibiotics were first used in farming towards the end of the war, in the form of intra-mammary penicillin preparations to treat bovine mastitis. At that time, milk was seen as an agricultural product which was highly susceptible to bacterial contamination, and farmers welcomed the opportunity to 'purify' their produce for the safety of consumers; it was only later that concern switched from the bacterial load of the product to the residues that might result from untimely or unregulated treatment. The use of antibiotics to treat and prevent disease has followed a similar path to that used in human medicine in terms of therapeutic and metaphylactic applications to treat and manage disease and improve population health, and the application of case-by-case strategic preventative treatments when animals are deemed at particular risk. However, in the late 1940s, studies examining the supplementation of B12 in chicks' diets found that B12 produced from the fermentation of Streptomyces aureofaciens, an antibiotic for use in human medicine, produced a better weight gain for chicks than B12 supplied from other sources, and a reduced amount of feed to bring the birds to market weight.