Abraham's lack of expression is only matched by Penty's perennially open-mouthed appearance, and their scenes are unintentionally funny because they try so hard to muster emotion.
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Their faces are meanwhile perhaps a little too old-school, clinging to the cartoonish shapes and rigid lack of expression that were once a necessity because of where the technology was at.
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She comes across as reserved, not least because she's found herself stuck with three strangers who seem liable to do something extremely dangerous or extremely stupid at any given moment, but conveys as much with a careful lack of expression as any explosive line reading could.
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The solemn faces and lack of expression on the passengers blatantly shows the harsh reality of emigrants and their depressing lifestyles of forced moves.
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"Christopher Hollyday: 'On Course'" (May 6, 1990). The Washington Post. p. G7. His playing was praised for its technical facility, but criticized for its lack of expression.
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Five of the 34 people diagnosed with Gómez–López-Hernández syndrome have also come from Brazil. Lack of expression from the WNT1, FGF8, FGF17, OTX2, fgf8, and fgf17 genes have all been implicated as possibly being the cause of cerebellum fusion.
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Lack of expression of lineage markers is used in combination with detection of several positive cell-surface markers to isolate HSCs. In addition, HSCs are characterised by their small size and low staining with vital dyes such as rhodamine 123 (rhodamine lo) or Hoechst 33342 (side population).
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Some self reactive T cells escape the thymus for a number of reasons, mainly due to the lack of expression of some self antigens in the thymus. Another type of T cell; T regulatory cells can down regulate self reactive T cells in the periphery. When immunological tolerance fails, autoimmune diseases can follow.
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V and H4.V. These histones cause changes in the tree-dimensional structure of the T. Brucei genome that results in a lack of expression. VSG genes are typically located in the subtelomeric regions of the chromosomes, which makes it easier for them to be silenced when they are not being used.
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The film was a moderate success in the Netherlands. David Rooney of Variety called the film "lazily compelling" and said that the comedy is drawn out. The Dutch film magazine Film Krant reviewed the film. Mark Duursma of Trouw said that nothing in the film is important and that the director has a lack of expression.
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The reader is forced to question the stability of the Hackee union: Chippy stays away from home long after Timmy's situation is resolved and returns to his wife only after being frightened from the tree by a bear entirely superfluous to the tale. At home, Chippy suffers with a head cold, but Mrs. Hackee's lack of expression in the illustration leaves the reader wondering how she took his abrupt return. One wonders why Mrs.
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The isoform of Pitx2 important for cardiogenesis is Pitx2c. The lack of expression of this particular isoform correlates with these congenital defects. Pitx2 mutations significantly reduce transcriptional activity of Pitx2 and synergistic activation between Pitx2 and NKX2(also important for development of the heart). The large phenotypic spectrum due to the mutation of Pitx2 may be attributed to a variety of factors including: different genetic backgrounds, epigenetic modifiers and delayed/complete penetrance.
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Several studies have attempted to utilize the possibility of controlling Ube3a expression through Ube3a-ATS. In AS, the paternal PWS-IC is not methylated, supposedly allowing Ube3a-ATS expression. Therefore, if methylation of the PWS-IC were possible, Ube3a-ATS transcription could be prohibited, allowing Ube3a expression from the paternal allele to make up for the lack of expression from the maternal allele. A one year study was performed with several AS patients.
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Activity theory provides a number of useful concepts that can be used to address the lack of expression for 'soft' factors which are inadequately represented by most process modelling frameworks. One such concept is the internal plane of action. Activity theory recognises that each activity takes place in two planes: the external plane and the internal plane. The external plane represents the objective components of the action while the internal plane represents the subjective components of the action.
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Due to its pivotal role in controlling cell migration, abnormalities or absences in the expression of Slit1, Slit2 and Slit3 are associated with a variety of cancers. In particular, Slit-Robo interaction has been implicated in reproductive and hormone dependent cancers, particularly in females. Under normal function, these genes act as tumor suppressors. Therefore, deletion or lack of expression of these genes is associated with tumorigenesis, particularly tumors within the epithelium of the ovaries, endometrium, and cervix.
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Human rights agencies and relatives of victims expressed shock after 18 soldiers accused in the Mylanthanai case were released on 27 November. A local Human Rights agency UTHR considered the jury's verdict unfair and reported that about the lack of expression of concern over the verdict among the international community.The Human Rights Task: Accountability First According to Northeastern Herald, although the constitution provides room for appalling such cases, the Attorney General refused to appeal the verdict citing convention.
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Immunohistochemical markers that have been suggested to be useful in making an accurate diagnosis of Bas-SqCC include positivity for p63 and high molecular weight keratin (i.e. 34betaE12), and lack of expression of thyroid transcription factor-1 (TTF-1). Among other pulmonary malignancies, the main differential diagnoses in suspected cases of Bas-SqCC include the high-grade neuroendocrine carcinomas, such as small cell carcinoma and large cell neuroendocrine carcinoma. The issue of differential diagnosis is particularly acute when the pathologist must use a small biopsy specimen or cytology.
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The final recommendations, published in October 1994, did not include such recommendations, apparently due to lack of expression of support for the proposal to the commission. As part of a 2002 marketing campaign, the plant conservation charity Plantlife chose the Grass- of-Parnassus as the county flower. Parnassus flowers had been associated with the county since 1951, when they were included in the coat of arms granted to the Cumberland County Council. They subsequently featured in the arms granted to Cumbria County Council and Copeland Borough Council, in both cases to represent Cumberland.
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More importantly, during latency, proviral DNA is hidden from the immune system, making treatment extremely difficult, if not impossible. Latent infection is described as the dormancy of a virus, by which proliferation of viral particles cease, yet the viral genome still remains incorporated as reservoirs within the cell. Although diversity among viruses' latent phase exist, ranging from selective viral gene expression (e.g., HSV expression of latency associated transcripts) to complete lack of expression, incorporation into the cell's genome (such as in retroviruses), and episomal persistence, common generalities too can be ascribed.
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HSD2 neurons do not produce a wide array of other proteins that typify most other subtypes of NTS neurons, including tyrosine hydroxylase, choline acetyltransferase, nitric oxide synthase, cholecystokinin, neurotensin, neuropeptide FF, substance P, somatostatin, inhibin-β, glucagon-like peptide-1, corticotropin-releasing hormone, dynorphin, calretinin, and calbindin. A small number of HSD2 neurons (less than 2%) may express the neuropeptide galanin. Their lack of expression of the aforementioned markers suggests that HSD2 neurons form a unique subpopulation within the NTS. To date, there is no information available about the electrophysiologic characteristics of these neurons.
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It is estimated that there are, on average, 2 to 20 cases of Möbius syndrome per million births. Although its rarity often leads to late diagnosis, infants with this disorder can be identified at birth by a "mask- like" lack of expression that is detectable during crying or laughing and by an inability to suck while nursing because of paresis (palsy) of the sixth and seventh cranial nerves. Also, because a person with Möbius syndrome cannot follow objects by moving their eyes from side to side, they turn their head instead.
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" The Associated Press reported "Passion? Yes. Power. No. Bocelli's voice – though robust in spirit and precisely in tune, even in the upper register – had a thin quality that never opened up." Similarly, classical music critic Andrew Clements found Bocelli's studio opera recordings consistently disappointing in quality: "Bocelli's profoundly unmusical contribution, with its unvaryingly coarse tone, wayward intonation and never a phrase properly shaped, fatally undermines all their contributions." Anne Midgette of The New York Times agreed, noting "a thinness of voice, oddly anemic phrasing (including shortchanging upper notes of phrases in a most untenorial manner), a curious lack of expression.
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Since hematopoietic stem cells cannot be isolated as a pure population, it is not possible to identify them in a microscope. Hematopoietic stem cells can be identified or isolated by the use of flow cytometry where the combination of several different cell surface markers (particularly CD34) are used to separate the rare Hematopoietic stem cells from the surrounding blood cells. Hematopoietic stem cells lack expression of mature blood cell markers and are thus called Lin-. Lack of expression of lineage markers is used in combination with detection of several positive cell-surface markers to isolate hematopoietic stem cells.
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Dicarboxylic aminoaciduria is a rare form of aminoaciduria (1:35 000 births) which is an autosomal recessive disorder of urinary glutamate and aspartate due to genetic errors related to transport of these amino acids. Mutations resulting in a lack of expression of the SLC1A1 gene, a member of the solute carrier family, are found to cause development of dicarboxylic aminoaciduria in humans. SLC1A1 encodes for EAAT3 which is found in the neurons, intestine, kidney, lung, and heart. EAAT3 is part of a family of high affinity glutamate transporters which transport both glutamate and aspartate across the plasma membrane.
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This seems to suggest that would be a crucial protein involved with bone metabolism and that retention of bone tissue by a protein as yet unknown. Nck1 expression increased twofold when involved with neurectomy-based unloading osteoporosis. This then follows that in a deficient organism this upregulation would not be possible and thus the body would have increased bone loss due to the lack of expression of Nck1 to deal with the stress, which is what happens in vivo. This acceleration of bone loss leads researchers to believe that the pathway for bone metabolism is highly regulated by several proteins that have yet to be discovered or incorporated into a schema.
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The expression of sequences at the mRNA level may be confirmed individually through conventional techniques such as quantitative PCR, or globally through more modern techniques such as RNA sequencing (RNA-seq). Similarly, expression at the protein level can be determined with high confidence for individual proteins using techniques such as mass spectrometry or western blotting, while ribosome profiling (Ribo-seq) provides a global survey of translation in a given sample. Ideally, to confirm that the gene in question arose de novo, a lack of expression of the syntenic region of outgroup species would also be demonstrated. Confirmation of gene expression is only one approach to infer function.
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Möbius syndrome does not prevent individuals from experiencing personal and professional success. Due to the importance of facial expression and smiling in social interaction, the inability to form either can lead to individuals with Möbius being perceived as unhappy, unfriendly or uninterested in conversations. Individuals who are familiar with Möbius patients such as family or friends can recognize other signals of emotion such as body language, to the point that they sometimes report forgetting that the person has facial paralysis. Indeed, people with Moebius syndrome are often adept at compensating for a lack of expression by using body language, posture, and vocal tone to convey emotion.
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Plasmodium vivax has a wide distribution in tropical countries, but is absent or rare in a large region in West and Central Africa, as recently confirmed by PCR species typing. This gap in distribution has been attributed to the lack of expression of the Duffy antigen receptor for chemokines (DARC) on the red cells of many sub-Saharan Africans. Duffy negative individuals are homozygous for a DARC allele, carrying a single nucleotide mutation (DARC 46 T → C), which impairs promoter activity by disrupting a binding site for the hGATA1 erythroid lineage transcription factor. In widely cited in vitro and in vivo studies, Miller et al.
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On the other hand, the study shows that subordinates in high power distances obey the gap between them and their leaders; they rarely interact with their leaders, if so, it is for a short period of time. The study further confirms that the ideas and solutions in this power index are given to them by their leaders, so it seems contradictory for those in the high-power distance to speak up about their concerns or ideas because they are accustomed to direction. Therefore, trying to inspire voice behavior deviates from the high-power index structure. This contradiction of the high-power index holds true showing that it weakens the leader- subordinate relationship causing a lack of expression.
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Chromosome 15 Angelman syndrome is caused by the lack of expression of a gene known as UBE3A in developing. This gene is located within a region of chromosome 15 known as 15q11-q13 and is part of the ubiquitin pathway. In fact, UBE3A codes for a very selective E6-AP ubiquitin ligase for which MAPK1, PRMT5, CDK1, CDK4, β-catenin, and UBXD8 have been identified as ubiquitination targets Typically, a fetus inherits a maternal copy of UBE3A and a paternal copy of UBE3A. In certain areas of developing brain, the paternal copy of UBE3A is inactivated through a process known as imprinting and the fetus relies on the functioning maternal copy of UBE3A in order to develop normally.
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Dominic has observed that Adam no longer exhibits the basic responses of survival instinct, such as scanning his surroundings or flinching in anticipation of danger, never twitching nor fidgeting because he never tires. Adam concedes that this gives only a vague awareness of what he touches. Dominic feels that what is worse is Adam's emotional detachment, his lack of expression, and aloofness, as if he is bored with human existence, and feels Adam is not applying the great intellect he accumulated over eight centuries to himself. Adam initially feels that Elalyth never forgave him for killing Vincent, but Albert does not believe this, pointing out that he still has her protection of immortality, though Adam fears that this is so that he could live a life tortured by guilt.
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The possibility to retain the rapid and non-focal assembly of receptors at the sites of cell contacts with the extracellular substrate has been noted. Integrins are not important in this type of invasive growth. Important aspects are the absence of proteolysis at the sites of cell- matrix interactions and the lack of expression of proteolytic enzymes that destroy the extracellular matrix. In vitro studies have demonstrated that, in the case of an amoeboid type of invasive growth, it is likely due to these properties that tumor cells are capable of moving at the highest speed in cultures (20 μm/min). Amoeboid-mesenchymal and mesenchymal-amoeboid transitions We have already noted the existence of a degree of plasticity and the possibility of a “shift” from one migration type to the other (from the mesenchymal type to the amoeboid one and vice versa) upon individual cell invasion.
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A map of Europe indicating the distribution of the carrion and hooded crows on either side of a contact zone (white line) separating the two species The carrion crow (Corvus corone) and hooded crow (Corvus cornix, including its slightly larger allied form or race C. c. orientalis) are two very closely related species whose geographic distributions across Europe are illustrated in the accompanying diagram. It is believed that this distribution might have resulted from the glaciation cycles during the Pleistocene, which caused the parent population to split into isolates which subsequently re-expanded their ranges when the climate warmed causing secondary contact. Further reading: Poelstra and coworkers sequenced almost the entire genomes of both species in populations at varying distances from the contact zone to find that the two species were genetically identical, both in their DNA and in its expression (in the form of mRNA), except for the lack of expression of a small portion (<0.28%) of the genome (situated on avian chromosome 18) in the hooded crow, which imparts the lighter plumage colouration on its torso.
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