Palpation may elicit, besides tenderness, points or regions of induration or intumescence.
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TST (tuberculin skin test) positive is measured by size of induration. The size of the induration considered to be a positive result depends on risk factors. For example, a low-risk patient must have a larger induration for a positive result than a high-risk patient. High-risk groups include recent contacts, those with HIV, those with chest radiograph with fibrotic changes, organ transplant recipients, and those with immunosuppression.
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Here channels periodically avulse in order to adjust to hydraulic constraints imposed by the induration of alluvial boundaries.
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In chronic vestibulitis, induration of vestibular skin and crusting is seen. Antibiotic steroid ointment is sometimes helpful. Chronic fissures can be cauterized with Silver Nitrate.
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Induration of 5mm or more with erythema (redness), or 10mm without, 48 hours post injection are positive Fernandez reactions. Unlike the tuberculin test however, another reaction occurs in lepromatous patients at the injection site 21 days post injection, also appearing as induration and possible ulceration. This late positive reaction is known as the Mitsuda reaction. These reactions differ dependent on the type of lepromin antigen used.
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T cells and myeloid cells are attracted to the site of reaction in the timeframe of 1-3 days and generate local inflammation. The reaction is read by measuring the diameter of induration (palpable raised, hardened area) across the forearm (perpendicular to the long axis) in millimeters. If there is no induration, the result should be recorded as "0 mm". Erythema (redness) should not be measured.
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The area of induration (NOT of erythema) is measured transversely across the forearm (left to right, not up and down) and recorded to the nearest millimetre.
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The company eventually built about 50 such plants.J. Stjernberg, O. Isaksson, J. C. Ion. "The grate-kiln induration machine - history, advantages, and drawbacks, and outline for the future".
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There may be some discoloration of the area of the bite. In other cases the skin reactions may be severe with marked pruritus and considerable erythema, oedema and induration. People also report headaches.
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The reached materials dissolved in the surface infiltrates in the weathered surface and cement the silica-aluminous remnant materials. The surface induration by means of this process is named case hardening.Dorn, R.L. 2004. Case hardening.
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Affected individuals may experience the following; swelling, redness, discharge, pain, shut eye, conjunctival infection, fever (mild), slightly blurred vision, teary eyes, and some reduction in vision. Typical signs include periorbital erythema, induration, tenderness and warmth.
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Treatment is mostly associated with mild to moderate injection-site reactions (local erythema, induration and pain), which disappear within 24–48 hours. Systemic reactions, such as flu-like symptoms and chills are less frequent, reversible, and self-limited.
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Though these lesions may resemble nodular melanoma, the lack of induration, slow growth, and lightening appearance upon diascopy suggest against it, and indicate a vascular lesion.Wolff and Johnson. Fitzpatrick's Color Atlas and Synopsis of Clinical Dermatology. The McGraw-Hill Companies. 2005.
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Folliculitis decalvans is an inflammation of the hair follicle that leads to bogginess or induration of involved parts of the scalp along with pustules, erosions, crusts, ulcers, and scale.Freedberg, et al. (2003). Fitzpatrick's Dermatology in General Medicine. (6th ed.). McGraw-Hill. .
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Induration, contact bleeding and rolled margins are features of a malignant ulcer. There may be nearby causative factor, e.g. a broken tooth with a sharp edge that is traumatizing the tissues. Otherwise, the person may be asked about problems elsewhere, e.g.
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In 1752 the construction began, and in 1757 the grand opening of the Hotel Saint-Côme de Montpellier took place. In 1743 Peyronie described a disorder characterized by induration of the corpora cavernosa of the penis. This condition is now referred to as Peyronie's disease.
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One of the illustrations from Illustrations of the Elementary Forms of Disease Carswell's major work, published in 1837, was Illustrations of the Elementary Forms of Disease, with coloured plates. He wrote also journal articles, and in the Cyclopædia of Practical Medicine the articles "Induration", "Melanosis", "Mortification", "Perforation", "Scirrhus", "Softening", and "Tubercle".
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The coalescence of papules on the face, particularly on the glabella, results in longitudinal folding and gives the appearance of a leonine facies. In scleromyxedema, symptoms can occur on larger part of the body. Redness and scleroderma-like induration occurs on the skin. In addition, the mobility of the lips, hands, arms, and legs is reduced.
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Currently administered human anthrax vaccines include acellular (United States) and live vaccine (Russia) varieties. All currently used anthrax vaccines show considerable local and general reactogenicity (erythema, induration, soreness, fever) and serious adverse reactions occur in about 1% of recipients.Splino M, et al. (2005), "Anthrax vaccines" , Annals of Saudi Medicine; 2005 Mar–Apr;25(2):143–9.
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Findings of tenderness, induration, pain and/or erythema along the course of a superficial vein usually establish a clinical diagnosis, especially in patients with known risk factors. In addition, there is often a palpable, sometimes nodular cord, due to thrombus within the affected vein. Persistence of this cord when the extremity is raised suggests the presence of thrombus.
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Brown induration is fibrosis and hemosiderin pigmentation of the lungs due to long standing pulmonary congestion (chronic passive congestion). Occurs with mitral stenosis and left sided heart failure. Pathology: The lung vessels are congested with blood and this leads to pulmonary edema when plasma escapes in alveolar spaces. Rupture of congested capillaries leads to release of hemosiderin from damaged red blood cells.
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An Arthus reaction is a local > vasculitis associated with deposition of immune complexes and activation of > complement. Immune complexes form in the setting of high local concentration > of vaccine antigens and high circulating antibody concentration. Arthus > reactions are characterized by severe pain, swelling, induration, edema, > hemorrhage, and occasionally by necrosis. These symptoms and signs usually > occur 4–12 hours after vaccination.
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Infections by dermatophytes affect the superficial skin, hair, and nails are named using "tinea" followed by the Latin term for the area that is affected. Manifestation of infection tends to involve erythema, induration, itching, and scaling. Dermatophytoses tend to occur in moist areas and skin folds. The degree of infection depends on the specific site of infection, the fungal species, and the host inflammatory response.
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The first skin changes in calciphylaxis lesions are mottling of the skin and induration in a livedo reticularis pattern. As tissue thrombosis and infarction occurs, a black, leathery eschar in an ulcer with adherent black slough are found. Surrounding the ulcers is usually a plate-like area of indurated skin. These lesions are always extremely painful and most often occur on the lower extremities, abdomen, buttocks, and penis.
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Complications of endovenous laser treatment can be categorized as minor, or serious. Minor complications include bruising (51%), hematoma (2.3%), temporary numbness (3.8%), phlebitis (7.4%), induration (46.7%), and a sensation of tightness (24.8%). More serious complications include skin burns (0.5%), deep venous thrombosis (0.4%), pulmonary embolism (0.1%), and nerve injury (0.8%). These rates of complications are derived from the Australian MSAC review of all available literature on the procedure.
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Injecting a Mantoux skin test The Mantoux test for TB involves intradermally injecting PPD (Purified Protein Derivative) tuberculin and measuring the size of induration 48-72 hours later. The Mantoux skin test is used in the United States and is endorsed by the American Thoracic Society and Centers for Disease Control and Prevention (CDC). If a person has had a history of a positive tuberculin skin test, another skin test is not needed.
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The Iron Plant Complex has 10 main production line units (the rest are auxiliary and back up units). Iron ores with large grains from Golgohar are converted by ball mills in the Pelletizing plant. After mixing with Chadermalou's smaller grains and bentonite in blending machines it is changed to pellets (diameter: 6–25 mm) and screened by a two-story roller screen. Pellets solidify in an induration tunnel or furnace at 1280 °C.
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In 1885 he published a pamphlet on Sounding for Gall Stones, and in the following year a work on Inflammation of the Liver, in which he advocated puncture of the capsule in congestive liver induration, and 'hepatic phlebotomy' for acute hepatitis. In 1868 his old pupil, George T. Brown, brought out a book on Histology, of demonstrations which Harley had given at University College. The second edition of the book Dr. Harley edited himself.
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Clinically, EPP is characterized by erythema, edema, shallow scars, and waxy induration of the skin, particularly on the face. Pseudoporphyria that clinically mimics EPP has been described almost exclusively in children taking naproxen for juvenile rheumatoid arthritis. Naproxen-induced pseudoporphyria seems to have a dimorphic presentation with the PCT-like pattern more often seen in the adult population and the EPP-like pattern more commonly seen in children, although some overlap has been documented.
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Superficial thrombophlebitis is a thrombosis and inflammation of superficial veins which presents as a painful induration with erythema, often in a linear or branching configuration forming cords. Superficial thrombophlebitis is due to inflammation and/or thrombosis, and less commonly infection of the vein. It is generally a benign, self-limited disorder, however, it can be complicated by deep vein thrombosis (DVT) and even pulmonary embolism (PE) Migratory superficial thrombophlebitis is known as Trousseau's syndrome.
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This test uses a small "button" that has four to six short needles coated with TB antigens (tuberculin), either an old tuberculin or a PPD-tuberculin. The needles are pressed into the skin (usually on the inner side of the forearm), forcing the antigens into the skin. The test is then read 48 to 72 hours later by measuring the size of the largest papule or induration. Indications are usually classified as positive, negative, or doubtful.
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Stiff skin syndrome (also known as "Congenital fascial dystrophy") is a cutaneous condition characterized by ‘rock hard’ induration, thickening of the skin and subcutaneous tissues, limited joint mobility, and mild hypertrichosis in infancy or early childhood. Immunologic abnormalities or vascular hyperactivity are not present in patients. Not much is known about it, cause or treatment, as it has only been reported 41 times throughout history. Not much is known about this, and further investigation is required.
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The size of induration is measured 48–72 hours later. Erythema (redness) should not be measured. Mantoux test injection site in a subject without chronic conditions or in a high-risk group clinically diagnosed as negative at 50 hours Tuberculin is a glycerol extract of the tubercle bacillus. Purified protein derivative (PPD) tuberculin is a precipitate of species-nonspecific molecules obtained from filtrates of sterilized, concentrated cultures. The tuberculin reaction was first described by Robert Koch in 1890.
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Hence, vasculitis, glomerulonephritis and arthritis are commonly associated conditions as a result of type III hypersensitivity responses. As observed under methods of histopathology, acute necrotizing vasculitis within the affected tissues is observed concomitant to neutrophilic infiltration, along with notable eosinophilic deposition (fibrinoid necrosis). Often, immunofluorescence microscopy can be used to visualize the immune complexes. Skin response to a hypersensitivity of this type is referred to as an Arthus reaction, and is characterized by local erythema and some induration.
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Further aggregation of immune complex- related processes induce a local fibrinoid necrosis with ischemia-aggravating thrombosis in the tissue vessel walls. The end result is a localized area of redness and induration that typically lasts a day or so. Arthus reactions have been infrequently reported after vaccinations containing diphtheria and tetanus toxoid. The CDC's description: > Arthus reactions (type III hypersensitivity reactions) are rarely reported > after vaccination and can occur after tetanus toxoid–containing or > diphtheria toxoid–containing vaccines.
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Bohor, B. F., and D. M. Triplehorn (1993) Tonsteins: altered volcanic ash layers in coal-bearing sequences Special Paper 285. Geological Society of America, Boulder, Colorado, 44 pp. In contrast, the alteration of a volcanic ashfall deposit in a marine environment typically produces a bentonite layer. The induration of tonsteins is in contrast to kaolin claystones that can be mined for kaolin clay, such as the ball clays found at Bovey Tracey which formed by the erosion of a nearby kaolinised granite.
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Based on the degree and type of local effect, bites can be divided into two symptomatic categories: those with little or no surface extravasation, and those with hemorrhages evident as ecchymosis, bleeding and swelling. In both cases there is severe pain and tenderness, but in the latter there is widespread superficial or deep necrosis and compartment syndrome. Serious bites cause limbs to become immovably flexed as a result of significant hemorrhage or coagulation in the affected muscles. Residual induration, however, is rare and usually these areas completely resolve.
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Microscopic examination of keratinocytes scraped from the buccal mucosa Tissue biopsy is usually indicated to rule out other causes of white patches and also to enable a detailed histologic examination to grade the presence of any epithelial dysplasia. This is an indicator of malignant potential and usually determines the management and recall interval. The sites of a leukoplakia lesion that are preferentially biopsied are the areas that show induration (hardening) and erythroplasia (redness), and erosive or ulcerated areas. These areas are more likely to show any dysplasia than homogenous white areas.
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Pretibial myxedema is almost always preceded by the ocular signs found in Graves' disease. It usually presents itself as a waxy, discolored induration of the skin—classically described as having a so-called peau d'orange (orange peel) appearance—on the anterior aspect of the lower legs, spreading to the dorsum of the feet, or as a non-localised, non-pitting edema of the skin in the same areas. In advanced cases, this may extend to the upper trunk (torso), upper extremities, face, neck, back, chest and ears. The lesions are known to resolve very slowly.
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Serious bites cause limbs to become immovably flexed as a result of significant hemorrhage or coagulation in the affected muscles. Residual induration, however, is rare and usually these areas completely resolve. Other bite symptoms that may occur in humans include edema, which may become extensive, shock, watery blood oozing from the puncture wounds, nausea and vomiting, subcutaneous bruising, blood blisters that may form rapidly, and painful swelling of the regional lymph nodes. Swelling usually decreases after a few days, except for the area immediately around the bite site.
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Later in the disease, as induration subsides, erythema gives way to a ruddy or bruised color. Duplex ultrasound identifies the presence, location and extent of venous thrombosis, and can help identify other pathology that may be a source of the patient's complaints. Ultrasound is indicated if superficial phlebitis involves or extends into the proximal one-third of the medial thigh, there is evidence for clinical extension of phlebitis, lower extremity swelling is greater than would be expected from a superficial phlebitis alone or diagnosis of superficial thrombophlebitis in question.
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It is important to evaluate for co-existent abscess, as this finding usually requires surgical drainage as opposed to antibiotic therapy alone. Physicians' clinical assessment for abscess may be limited, especially in cases with extensive overlying induration, but use of bedside ultrasonography performed by an experienced practitioner readily discriminates between abscess and cellulitis and may change management in up to 56% of cases. Use of ultrasound for abscess identification may also be indicated in cases of antibiotic failure. Cellulitis has a characteristic "cobblestoned" appearance indicative of subcutaneous edema without a defined hypoechoic, heterogeneous fluid collection that would indicate abscess.
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The body is divided into four sections (head (H) (10% of a person's skin); arms (A) (20%); trunk (T) (30%); legs (L) (40%)). Each of these areas is scored by itself, and then the four scores are combined into the final PASI. For each section, the percent of area of skin involved, is estimated and then transformed into a grade from 0 to 6: Within each area, the severity is estimated by three clinical signs: erythema (redness), induration (thickness) and desquamation (scaling). Severity parameters are measured on a scale of 0 to 4, from none to maximum.
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At the boundary between these two terranes, is the Esk Head Belt, a 20 km wide melange of rocks, broken and deformed by earthquakes along the fault lines near the boundary. Further to the east of the Wairarapa-Masterton Basin, are successively younger Cretaceous (140-65 Ma) sandstones and mudstones (sometimes called the Waioeka Terrane), that can be regarded as part of the Torlesse Composite Terrane. There seems to be some disagreement on where to place the boundary between basement rocks and overlying rocks, and the decision seems to be based on the degree of induration. In the east, even younger and softer sandstones and mudstones occur.
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In clinical trials, the term reactogenicity refers to the property of a vaccine of being able to produce common, "expected" adverse reactions, especially excessive immunological responses and associated signs and symptoms, including fever and sore arm at injection site. (Much less frequently, the term has also been applied to therapeutic drug trials.) Other manifestations of reactogenicity typically identified in such trials include bruising, redness, induration, and swelling. The term reactogenicity was coined by the US Food and Drug Administration (FDA). Typically, reactogenicity is observed upon the administration of an adjuvant, which is a chemical additive intended for enhancing the recipient's immune response to the antigen that is present in a vaccine, but can also be observed in non-adjuvanted vaccines.
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According to the U.S. guidelines, there are multiple size thresholds for declaring a positive result of latent tuberculosis from the Mantoux test: For testees from high-risk groups, such as those who are HIV positive, the cutoff is 5 mm of induration; for medium risk groups, 10 mm; for low-risk groups, 15 mm. The U.S. guidelines recommend that a history of previous BCG vaccination should be ignored. For details of tuberculin skin test interpretation, please refer to the CDC guidelines (reference given below). The UK guidelines are formulated according to the Heaf test: In patients who have had BCG previously, latent TB is diagnosed if the Heaf test is grade 3 or 4 and have no signs or symptoms of active TB; if the Heaf test is grade 0 or 1, then the test is repeated.
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