Jason Emer: The plasma fibroblast device is one of the newest noninvasive aesthetic treatments to use energy on the skin very focally to help improve wrinkles, pores, and complexion.
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"Bungee cord and airbag injuries seem to more frequently result in traumatic iridodialysis because of the focally concentrated strong force," Bell said, adding that airbags save lives, and fear of this extremely rare eye injury is no reason for avoiding them.
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Adenomyosis may involve the uterus focally, creating an adenomyoma. With diffuse involvement, the uterus becomes bulky and heavier.
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Microscopic necrosis can be seen focally in MTSCC. Its significance is unknown. The presence of any necrosis should be mentioned in the pathological report.
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Am J Surg Pathol. 2020;44(7):922-933. doi:10.1097/PAS.0000000000001447 Cytokeratin is typically expressed, at least focally. TLE1, BCL2 and CD99 may be positive but lack specificity.
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The sustentacular cells are S-100 positive and focally positive for glial fibrillary acidic protein. By histochemistry, the paraganglioma cells are argyrophilic, periodic acid Schiff negative, mucicarmine negative, and argentaffin negative.
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"Yondr Pouch by Yondr (Focally, LLC)", EdSurge. Accessed 25 January 2018.Tovia Smith, "A School's Way To Fight Phones In Class: Lock 'Em Up", NPR, 11 January 2018. Accessed 25 January 2018.
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The epithelial component in EMECL's typically strongly express cytokeratins, but are negative for actin and S-100 protein, while the myoepithelial component stains strongly for actin and S-100 protein, and only focally weakly for cytokeratins.
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IRF8 mediates the expression of Fas, Bax, FLIP, Jak1 and STAT1 to mediate apoptosis in non- hemotopoietic cancer cells. Analysis of human cancer genomics database revealed that IRF8 is not significantly focally amplified across the entire dataset of 3131 tumors, but is significantly focally deleted across the entire dataset of 3131 tumors, suggesting that IRF8 is potentially a tumor suppressor in humans. Molecular analysis indicated that the IRF8 gene promoter is hypermethylated in human colon carcinoma cells, suggesting that these cells might use DNA methylation to silence IRF8 expression to advance the disease.
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Cancer cells in general, regardless of their Fas apoptosis sensitivity, depend on constitutive activity of Fas. This is stimulated by cancer-produced Fas ligand for optimal growth. Although Fas has been shown to promote tumor growth in the above mouse models, analysis of the human cancer genomics database revealed that FAS is not significantly focally amplified across a dataset of 3131 tumors (FAS is not an oncogene), but is significantly focally deleted across the entire dataset of these 3131 tumors, suggesting that FAS functions as a tumor suppressor in humans. In cultured cells, FasL induces various types of cancer cell apoptosis through the Fas receptor.
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The definitive diagnosis of HN requires morphological examination. Common histological features can be identified in the renal and glomerular vasculature. Glomerulosclerosis is often present, either focally or globally, which is characterized by hardening of the vessel walls. Also, luminal narrowing or the arteries and arterioles of the kidney system.
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The fascicular arrangement of the tumour can be observed focally. The tumour cells are entrenched in a highly vasculated myxoid background. The vessels are thin arborizing with or without thrombi. The individual tumour cells are spindle to ovoid shaped, with indistinct cell borders, bland nuclear chromatin, inconspicuous nucleoli, and scant eosinophilic cytoplasm.
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Solid pseudopapillary tumours consist of solid sheets of cells that are focally dyscohesive. The cells in the lesion usually have uniform nuclei with occasional nuclear grooves, eosinophilic or clear cytoplasm and PAS positive eosinophilic intracytoplasmic globules. Necrosis is usually present and, as cell death preferentially occurs distant from blood vessels, lead to the formation of pseudopapillae.
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The major causes of flank pain and hematuria, such as nephrolithiasis and blood clot, are typically not present. Renal arteriography may suggest focally impaired cortical perfusion, while renal biopsy may show interstitial fibrosis and arterial sclerosis. The pain is typically severe, and narcotic therapy is often prescribed as a way to manage chronic pain. Sleep can be difficult because the supine position increases pressure on the flank.
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The technique uses pulsed radio frequency energy delivered via catheter at frequencies of 300–750 kHz for 30 to 60 seconds. Thermal pulsed radio frequency takes advantage of high current delivered focally by an electrode to ablate the tissue of interest. Generally the tissue/electrode temperature reached is 60 to 75 °C resulting in focal tissue destruction. Thermal pulse radio frequency ablation has also been used for lesioning of peripheral nerves to reduce chronic pain.
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The muscle insertion hurts very focally as it joins into the bone, but there is little to no pain at all with passive motion. While it is typically associated with other autoimmune diseases, like spondyloarthropaties and psoriasis (thought to often precede psoriatic arthritis). A common autoimmune enthesitis is at the heel, where the Achilles tendon attaches to the calcaneus. There are some cases of isolated, primary enthesitis which are very poorly studied and understood.
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The aim was to create a system that could use the entire range of the company's 35 mm spherical lenses. This led to the 2004 introduction of the Genesis HD—a full bandwidth (4:4:4) HD SDI camera with improved colorimetry- and sensitometry-related specs. Its Super 35 mm film–sized recording area made it focally compatible with regular 35 mm lenses, giving it a true 35 mm depth of field.Holben, Jay.
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Galli–Galli disease is a rare inherited condition that has close resemblance clinically to Dowling-Degos' disease, but is histologically distinct, characterized by skin lesions that are 1- to 2-mm slightly keratotic red to dark brown papules which are focally confluent in a reticulate pattern.James, William; Berger, Timothy; Elston, Dirk Andrews' Diseases of the Skin: Clinical Dermatology. (10th ed.). Saunders. . The disease is also characterized by slowly progressive and disfiguring reticulate hyperpigmentation of the flexures, clinically and histopathologically diagnostic for Dowling-Degos disease but also associated with suprabasal, nondyskeratotic acantholysis.
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Another CNS manifestation of NF-1 is the so-called "unidentified bright object" or UBO, which is a lesion which has increased signal on a T2 weighted sequence of a magnetic resonance imaging examination of the brain. These UBOs are typically found in the Cerebral peduncle, pons, midbrain, globus pallidus, thalamus, and optic radiations. Their exact identity remains a bit of a mystery since they disappear over time (usually, by age 16), and they are not typically biopsied or resected. They may represent a focally degenerative bit of myelin.
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The CN Tower, located in downtown Toronto, Ontario, Canada, The 1970s represented a turning point away from the International Style and Modernist planning. Brutalist architecture had been seen in Canada prior to the decade, but became more dominant in the 1970s with the backlash against the International Style. The style emphasized the reflection of the functional components of the interior in the exterior, along with geometric and sculptural uses of concrete on the interior and exterior of the building. It was a style used focally for institutional buildings for government, academic, and cultural uses, but also for high-rise residential and commercial buildings.
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CDKN2A is a tumour suppressor gene that encodes a tumor suppressor protein, p16 (cyclin-dependent kinase inhibitor 2A) and inhibits the kinase activity of the cyclin-dependent kinases CDK4 and CDK6, which in turn induce cell cycle arrest. p16 expression is cell cycle dependent and is expressed focally in only about 5–10% of normal squamous epithelium. Like most HPV+ cancers, HPV+OPC express p16 but the latter does not function as a tumour-suppressor, because the mechanism by which this is achieved, pRb, has been inactivated by E7. p16 is upregulated (over-expressed) due to E7-related loss of pRB with reduced negative feedback, whereas it is downregulated in up to 90% of HPV-OPC.
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The person may be treated by targeted therapies in order to reduce the size or number of active tumors, with the goal of once again qualifying for liver transplant after this treatment. # Palliative intention: for more advanced disease, including spread of cancer beyond the liver or in persons who may not tolerate surgery, treatment intended to decrease symptoms of disease and maximize duration of survival. Loco-regional therapy (also referred to as liver-directed therapy) refers to any one of several minimally-invasive treatment techniques to focally target HCC within the liver. These procedures are alternatives to surgery, and may be considered in combination with other strategies, such as a later liver transplantation.
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Risk factors for uterine atony include prolonged labor, precipitous labor (labor lasting less than 3 hours), uterine distension (multi-fetal gestation, polyhydramnios, fetal macrosomia), fibroid uterus, chorioamnionitis, indicated magnesium sulfate infusions, and prolonged use of oxytocin. Ineffective uterine contraction, either focally or diffusely, is additionally associated with a diverse range of etiologies including retained placental tissue, placental disorders (such as morbidly adherent placenta, placenta previa, and abruption placentae), coagulopathy (increased fibrin degradation products) and uterine inversion. Body mass index (BMI) above 40 (class III obesity) is also a recognized risk factor for postpartum uterine atony. Magnesium sulfate, used routinely in patients with preeclampsia and eclampsia, has the side effect of compromising post delivery uterine contractility; this may contribute to the observed association of hypertensive disease of pregnancy with severe postpartum hemorrhage caused by atony.
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