A urinoma, also pararenal pseudocyst, is an encapsulated collection of extravasated urine and typically found in the area adjacent to the kidneys or to extend into the retroperitoneum.
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In many ways, extravasated platelets in trauma perform a similar function to tissue macrophages and mast cells exposed to microbial molecular signatures in infection: they become activated, and secrete molecular mediators – vasoactive amines, eicosanoids, and cytokines – that initiate the inflammatory process.
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Micrograph showing fibrin (dark pink amorphous material) in a blocked vein surrounded by extravasated red blood cells (right of image). An artery (left of image) and the amnion (far left of image) is also seen. Placenta in a case of fetal thrombotic vasculopathy. H&E; stain.
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A high power image of an endolymphatic sac tumor showing clear cytoplasm in cuboidal cells lined up along papillae. The microscopic appearance shows an unencapsulated, destructive growth, remodeling and invading bone. The tumor is arranged as simple, broad, non-complex papillary projections without large cystic spaces. The spaces are often fluid filled, have extravasated erythrocytes and/or inspissated material.
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Perinephritis is an infection of the surroundings of the kidney either right or left. It can be the result of extravasated infiltration of the bacteria out of the renal pelvis (pyelonephritis) or a result of another kidney infection. The consequences include the infection of the neighbouring organs (for example transverse colon) or retroperitoneum, and/or hypertension. Perirenal abscess also may occur.
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When skin is blanched, it takes on a whitish appearance as blood flow to the region is prevented. This occurs during and is the basis of the physiologic test known as diascopy. Blanching of the fingers is also one of the most clinically evident signs of Raynaud's phenomenon. Blanching is prevented in gangrene as the red blood corpuscles are extravasated and impart red color to the gangrenous part.
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Shoulder arthroscopy is typically limited to about 90-120 minutes before the swelling from fluid extravasation interferes with the procedure, and presents a potential risk to the patient. Typically, fluid extravasation is managed by controlling fluid pressure, or hastening the procedure. Arthroscopic instrumentation such as the newer Extravastat devices to drain extravasated fluid from the soft tissue during shoulder and hip arthroscopy has been reported to be beneficial in reducing fluid extravasation and swelling.
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If dural tear is associated with a brain injury, wide exposure of the wound is done to examine the extent of brain damage. All devitalized brain tissues are removed along with extravasated blood, foreign bodies and pieces of bone. All devitalized tissue and foreign bodies are removed by a combination of irrigation and suction. Following dural repair, skull deficit is treated by using moulded tantalum plates or acrylic inlays, three to six months after the head injury.
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Its network of capillaries and collecting lymphatic vessels work to efficiently drain and transport extravasated fluid, along with proteins and antigens, back to the circulatory system. Numerous intraluminal valves in the vessels ensure a unidirectional flow of lymph without reflux. Two valve systems, a primary and a secondary valve system, are used to achieve this unidirectional flow. The capillaries are blind-ended, and the valves at the ends of capillaries use specialised junctions together with anchoring filaments to allow a unidirectional flow to the primary vessels.
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He was born at Jesmond near Newcastle-upon- Tyne on 21 December 1828 the son of Richard Burdon (1791-1865) and his wife Elizabeth Sanderson. His paternal grandfather was Sir Thomas Burdon. He received his medical education at the University of Edinburgh with the thesis "On the metamorphoses of the coloured corpuscles in extravasated blood" and at Paris. Settling in London, he became Medical Officer of Health for Paddington in 1856 and four years later physician to the Middlesex Hospital and the Brompton Consumption hospitals.
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An injury to the urethra leaving Buck's fascia intact results in a collection of urine (extravasation) limited to the penis, deep to Buck's fascia. However, if the injury to the bulb of the penis results in urethral injury accompanying a tear of the Buck's fascia, then extravasated blood and urine would accumulate in the superficial perineal space, passing into the penis (outer to Buck's fascia) as well as the scrotum and lower anterior abdominal wall. Extravasation of urine involving a compromised Buck's fascia can be appreciated clinically by blood collecting in the superficial pouch, resulting in a 'butterfly'-shaped region around the penis.
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The infarct generally results grossly in a wedge shaped area of necrosis with the apex closest to the occlusion and the base at the periphery of the organ. The margins will become better defined with time with a narrow rim of congestion attributable to inflammation at the edge of the lesion.Robbins Basic Pathology Relatively few extravasated red cells are lysed so the resulting hemosiderosis is limited and results in a progressively more pale area of infarction with time. Ischemic coagulative necrosis results and fibrosis of the affected area develops from the reparative response beginning at the preserved margins and working its way inwards.
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The second stage features the reabsorption of the initially extravasated fluid and albumin from the tissues, and it usually lasts 1 to 2 days. Intravascular fluid overload leads to polyuria and can cause flash pulmonary edema and cardiac arrest, with possibly fatal consequences. Death from SCLS typically occurs during this recruitment phase because of pulmonary edema arising from excessive intravenous fluid administration during the earlier leak phase. The severity of the problem depends on to the quantity of fluid supplied in the initial phase, the damage that may have been sustained by the kidneys, and the promptness with which diuretics are administered to help the patient discharge the accumulated fluids quickly.
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Elevated prolactin levels have the direct effects of increasing secretory activity of breast lobules, maintaining tight junctions of the ductal epithelium, preventing involution of the breast gland after weaning and are known to stimulate the immune system, contributing to both physiological and pathological granulomatous lesions and non-caseating granulomas. PRL is also secreted locally in the breast and local secretion by lymphocytes may be enhanced during inflammatory reactions. Autoimmune reaction to extravasated fat and protein rich luminal fluid (denaturized milk) resulting from the secretory activity is assumed to be one of the triggers of IGM. Several other hormones can contribute to PRL signaling in the breast gland, high levels of insulin caused for example by peripheral insulin resistance (resulting from pregnancy, gestational diabetes or developing diabetes mellitus type 2) will enhance the galactogenic and antiapoptotic effects of PRL and growth hormone by acting synergistically with IGF-1.
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The clinical appearance of pityriasis rosea in some cases is similar to that of secondary syphilis, and rapid plasma reagin testing should be performed if there is any clinical concern for syphilis. A biopsy of the lesions will show extravasated erythrocytes within dermal papillae and dyskeratotic cells within the dermis. A set of validated diagnostic criteria for pityriasis rosea is as follows: A patient is diagnosed as having pityriasis rosea if: # On at least one occasion or clinical encounter, he / she has all the essential clinical features and at least one of the optional clinical features, and # On all occasions or clinical encounters related to the rash, he / she does not have any of the exclusional clinical features. The essential clinical features are the following: # Discrete circular or oval lesions, # Scaling on most lesions, and # Peripheral collarette scaling with central clearance on at least two lesions.
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