Even with the abundance of products, there is sometimes rarity in the form of limited editions and discontinuations.
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The drug was found to be generally well-tolerated with no serious adverse events or discontinuations reported, Sage said.
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Discontinuations due to adverse events occurred in 7.7 percent of talazoparib patients and 9.5 percent in the chemotherapy group.
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Enanta said study results showed its therapy was generally safe and well tolerated and no drug discontinuations were observed.
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Patient discontinuations of the Kalydeco/tezacaftor combination due to adverse side effects, including respiratory-related side effects, were low and similar to placebo.
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Patient discontinuations of the Kalydeco/tezacaftor combination due to adverse side effects, including respiratory-related side effects, was low and similar to placebo.
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EDP-938 was generally safe and well tolerated and no drug discontinuations were observed, the results showed Reporting by Saumya Sibi Joseph in Bengaluru; Editing by Shinjini Ganguli
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He pointed out product discontinuations are on the rise, and while more generic drugs are being approved, there is also an increase in the number of approvals that aren't being launched.
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Compared to the control group, people taking the drug experienced more discontinuations, anaphylaxis, and a chronic inflammatory condition that injures the esophagus called eosinophilic esophagitis, even though both groups were told to avoid peanuts as usual.
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It will never scale the heights of Google's original ambitions, and after all its fragmentation into smaller bits, its ultimate fate is most likely to be as another bullet point on Google's spring cleaning list of service discontinuations.
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"As in other reports on its use, the side effects of headache, fatigue, dizziness, diarrhea and nausea let to twice the number of discontinuations in the lorcaserin group as in the placebo group, although the total rates of discontinuation were similar in the two groups," they noted.
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ANNOUNCES FOURTH QUARTER AND FULL YEAR 2017 RESULTS * CAPITAL EXPENDITURES FOR 2018 ARE EXPECTED TO BE $2 MILLION TO $3 MILLION * TURNING POINT BRANDS - TO CONTINUE SKU RATIONALIZATION EFFORTS WHILE DISCONTINUING PRODUCTS THAT DO NOT WARRANT EXPENSE TO GET FDA COMPLIANCE * TURNING POINT - IDENTIFIED PRODUCTS FOR 2018 RATIONALIZATION & ESTIMATE SKU DISCONTINUATIONS WILL UNFAVORABLY IMPACT YOY SALES BY ABOUT $3.5 MILLION Source text for Eikon: Further company coverage:
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Trident gum was introduced to the British market in 2007. Seven flavours of Trident currently exist in the UK, after a period of new flavours and discontinuations.
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The banknote is protected with multiple security features, like watermarks and microprinting, which document its authenticity. The ten złotych note has been used since 1794, along with the rest of the first złoty banknotes, although there were some temporary discontinuations in its usage.
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Argentina 1929 at RSSSF Abandonments of games, discontinuations, and withdrawals were quite common in these early seasons (cf., for instance, the second half of the 1930 season Argentina 1930 at RSSSF). The Argentina national team won a new edition of Copa América.
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Retrieved 13 July 2020. According to the agency, the shortage of valsartan was resolved in 03/04/2020,Current and Resolved Drug Shortages and Discontinuations Reported to FDA accessdata.fda.gov. Retrieved 13 July 2020. but the availability of the generic form remained unstable into July 2020.
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More than half a dozen low-cost carriers entered the Indian market in 2004–05. Major new entrants included Air Deccan, Air Sahara, Kingfisher Airlines, SpiceJet, GoAir, Paramount Airways and IndiGo. But Indian aviation industry struggled due to economic slowdown, rising fuel and operation costs. This led to consolidation, buy outs and discontinuations in the Indian airline industry.
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Major new entrants included Air Deccan, Air Sahara, Kingfisher Airlines, SpiceJet, GoAir, Paramount Airways and IndiGo. Kingfisher Airlines became the first Indian air carrier on 15 June 2005 to order Airbus A380 aircraft worth 3 billion. However, Indian aviation would struggle due to an economic slowdown and rising fuel and operation costs. This led to consolidation, buyouts and discontinuations.
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Agomelatine is an atypical antidepressant used to treat major depressive disorder. One review found that it is as effective as other antidepressants with similar discontinuation rates overall but less discontinuations due to side effects. Another review also found it was similarly effective to many other antidepressants. Common side effects include weight gain, feeling tired, liver problems, nausea, headaches, and anxiety.
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However, the subsequent TENERE head-to-head comparison trial reported that "although permanent discontinuations [of therapy] were substantially less common among MS patients who received teriflunomide compared with interferon beta-1a, relapses were more common with teriflunomide." The drug was approved for use in the United States in September 2012 and for use in the European Union in August 2013.
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The season was marred by mass abandonment of games, defending Argentine champion Huracán withdrew from 8 of its fixtures leaving them to finish in 14th place in the group. Several other teams withdrew from multiple games.Argentina 1929 at RSSSF Abandonments of games, discontinuations, and withdrawals were quite common in these early seasons (cf., for instance, the second half of the 1930 season Argentina 1930 at RSSSF).
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Drug holidays (or "structured treatment interruptions") are intentional discontinuations of antiretroviral drug treatment. As mentioned above, randomized controlled studies of structured treatment interruptions have shown higher rates of opportunistic infections, cancers, heart attacks and death in patients who took drug holidays. With the exception of post exposure prophylaxis, current treatment guidelines do not call for the interruption of drug therapy once it has been initiated.
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Desvenlafaxine is primarily used as a treatment for major depressive disorder. Use has only been studied up to 8 weeks. It may be less effective than venlafaxine, although some studies have found comparable efficacy with a lower rate of nausea. Doses of 50–400 mg/day appear effective for major depressive disorder, although no additional benefit was demonstrated at doses greater than 50 mg/day, and adverse events and discontinuations were more frequent at higher doses.
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Watches and warnings in the United States began on August 27, with a hurricane watch being issued from Sebastian Inlet to Fernandina Beach in Florida. A tropical storm warning was also issued for much of the same area several hours later. As Dennis began turning northward, the threat of the storm striking Florida lessened, which resulted in discontinuations of the watches and warnings. Watches and warnings were issued from South Carolina to Virginia, beginning with a hurricane watch from north of Savannah, Georgia, to Surf City, North Carolina.
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Similar to ROIC, ROA, expressed as a percent, measures the company's ability to make money from its assets. To measure the ROA, take the pro forma net income divided by the total assets. However, because of very common irregularities in balance sheets (due to things like Goodwill, write- offs, discontinuations, etc.) this ratio is not always a good indicator of the company's potential. If the ratio is higher or lower than expected, one should look closely at the assets to see what could be over or understating the figure.
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Extrapyramidal symptoms (EPS), also known as extrapyramidal side effects (EPSE) if drug-induced, are movement disorders, which include acute and long- term symptoms. These symptoms include dystonia (continuous spasms and muscle contractions), akathisia (may manifest as motor restlessness), parkinsonism (characteristic symptoms such as rigidity), bradykinesia (slowness of movement), tremor, and tardive dyskinesia (irregular, jerky movements). Extrapyramidal symptoms are a reason why subjects drop out of clinical trials of antipsychotics; of the 213 (14.6%) subjects that dropped out of the one of the largest clinical trials of antipsychotics (the CATIE trial, which included 1460 randomized subjects), 58 (27.2%) of those discontinuations were due to EPS.
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