Our devitalization process is proprietary so I can't really discuss it, but it is very humane.
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The indication of this pulpotomy procedure is when pulp exposure occurs during caries removal in a primary tooth with a normal pulp or reversible pulpitis or after a traumatic pulp exposure. Then, the coronal tissue is amputated, and the remaining radicular tissue is judged to be vital without suppuration, pus, necrosis, or excessive bleeding which cannot be controlled by a moist cotton pellet (with saline) after several minutes, and there are no radiographic signs of infection or pathologic resorption. Pulpotomy therapy can be classified according to the following treatment objectives: devitalization (mummification, cauterization), preservation (minimal devitalization, noninductive), or regeneration (inductive, reparative).
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In most people, scalp hair growth will halt due to follicle devitalization after reaching a length of generally two or three feet. Exceptions to this rule can be observed in individuals with hair development abnormalities, which may cause an unusual length of hair growth.
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Multiple visits with application of formocresol in pulpotomy is used to fix the radicular pulp completely to reduce pulp infection. The radicular pulp was theoretically sterilized and devitalized, thereby reducing infection and internal resorption. Another form of nonchemical devitalization emerged: electrosurgical pulpotomy. Electrocautery releases heat that denatures pulp and reduces bacterial contamination.
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563p The dagger nematode causes the devitalization of root tips and overall root death when they feed at the root tips and root sides of strawberry plants. Reddish- brown lesions that turn black and necrotic with time result at the sites of feeding, and result in reduced root systems and stunted tops.Perry, V. G. (1958). Parasitism of two species of dagger nematode (Xiphinema americanum and X. chambersi) to strawberry. Phytopathology.
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Tumor formation has been observed when miR-143 and miR-145 are down-regulated, particularly in colon and gastric cancer cells. When expressed in colon cancer cells, miR-143 and miR-145 are able to slow growth at the translational level by interfering with MAPK7, an enzyme responsible for cell growth. As an avenue of therapeutic research, chemical devitalization (i.e., artificial modification) of miR-143 and miR-145 may prove to be more effective version of their natural counterparts.
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Ferric sulphate is used to arrest pulpal bleeding by forming a sealing membrane through the agglutination of the blood proteins with ferric and sulfate ions. This metal-protein clot at the surface of the pulp may act as a barrier to external irritants. The physiological clot formation is thought to be able to minimise inflammation and internal resorption compared to calcium hydroxide. Most importantly, ferric sulphate causes minimal devitalization and subsequent preservation of the pulp tissue.
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Following the advice of DeBakey and Knyazev, the medical team attempted an arterial bypass. The first surgery was done in the night of January 12. At first, the operation appeared to have been a success, but after few hours, it became clear that the operation was not successful. Due to severe damage to the arteries, which led to the interruption of blood flow and accelerated tissue devitalization of the left leg, Tito's left leg was amputated on January 20, to prevent the spread of gangrene.
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