But as college sports "deregulates" to better serve athletes—ahem—they probably shouldn't count on it.
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"But if I spend three to five minutes on the body scan, it deregulates them almost immediately."
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The rule deregulates pricing in a majority of counties and more than 90 percent of buildings using the services.
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Instead, Wheeler is pushing Trump's so-called Affordable Clean Energy sham that deregulates emissions' enforcement and politicizes climate science.
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There are Trump investments in many countries involved in TISA, which deregulates the real estate, construction, property management, retail, and finance sectors.
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She also manages to get rich quick because, as a stockholder in oil and gas companies, she deregulates those industries and their stock prices theoretically skyrocket.
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And they argue that the Energy and Commerce Committee has not been exercising enough oversight of the agency as it deregulates the media and broadband industries.
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If the Trump administration, which is expected to target the FDA, deregulates stem cell clinics, Dr. Steenblock might never have to prove that his treatments work.
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The SHARE Act also deregulates armor-piercing ammunition by removing the federal government's authority to ban such ammo if the manufacturer says it is intended for recreational purposes.
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As the Trump administration deregulates at an historic pace, it is no coincidence that business optimism is hitting historic highs, driving both increased investment and greater GDP growth.
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No matter how much good the president does, no matter how he reshapes the judiciary, deregulates the regulatory states, it&aposs never good enough, and there&aposs always a problem.
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The goal was to systematically push the rents of regulated apartments in Manhattan and Brooklyn past the threshold that deregulates the apartments, thrusting them into the more lucrative free market.
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But the net impact of a Britain outside the EU will be to make the operating environment for business more difficult, though it is possible that a Britain outside the EU deregulates in some respects.
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Meanwhile, sanctioning the Open Skies deal, which deregulates flights between the United States and Brazil and was approved by Brazil's Senate earlier this month, would clear the way for a partnership between American Airlines Group Inc and LATAM Airlines Group SA .
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The corresponding Bcl11a mouse gene is a common site of retroviral integration in myeloid leukemia, and may function as a leukemia disease gene, in part, through its interaction with BCL6. During hematopoietic cell differentiation, this gene is down-regulated. It is possibly involved in lymphoma pathogenesis since translocations associated with B-cell malignancies also deregulates its expression. In addition, BCL11A has been found to play a role in the suppression of fetal hemoglobin production.
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TRRAP is an adaptor protein, which is found in various multiprotein chromatin complexes with histone acetyltransferase activity (HAT), which in turn is responsible for epigenetic transcription activation. TRRAP has a central role in MYC (c-Myc) transcription activation, and also participates in cell transformation by MYC. It is required for p53/TP53-, E2F1-, and E2F4-mediated transcription activation. It is also involved in transcription activation mediated by the adenovirus E1A, a viral oncoprotein that deregulates transcription of key genes.
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The protein encoded by this gene (p35) is a neuron-specific activator of cyclin-dependent kinase 5 (CDK5); the activation of CDK5 is required for proper development of the central nervous system. The p35 form of this protein is proteolytically cleaved by calpain, generating a p25 form. The cleavage of p35 into p25 results in relocalization of the protein from the cell periphery to nuclear and perinuclear regions. P25 deregulates CDK5 activity by prolonging its activation and changing its cellular location.
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They are critical for ClpP interaction with its substrate and ATPases. When ADEP binds, the β-loops shift outward and this is accompanied by the shifts of two α-helices (α1 and α2), four β-strands (β1, β2, β3 and β5) and other loops which lead to the opening of the ClpP pore. In summary, ADEP4 deregulates ClpP function and changes it from a closed state to an open one. At this point its specific proteolytic activity becomes a less controlled process, with the destruction of proteins that are around in the targeted cell.
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Of the many transcriptional regulators of hematopoiesis, nearly all induce leukemia when aberrant. Chromosomal translocation is a hallmark of leukemia, and TAL1-induced translocation deregulates expression at the locus, while RUNX1-induced translocation results in chimeric fusion proteins. These chimeric transcription factors can result in the improper repression or activation of the target gene, as well as the inappropriate recruitment of chromatin-modifying enzymes. PAX5 and Notch mutations can result in B-cell and T-cell leukemias, respectively.. Dysregulation of stromal cells can in some cases induce genetic lesions in hematopoietic compartment; for example, mutations in the osteoblastic lineage cells resulted in malignant hematopoiesis .
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During the post-war period several large resource lines were opened in Quebec, Labrador, and British Columbia – several of which are not directly connected to the main North American network. In 1978 the government created Via Rail which took over all national passenger service in the country. In 1987 the National Transportation Act partially deregulated the railway industry in Canada and removed much of the red tape that railways experienced when attempting to abandon unprofitable lines; however, the NTA is now viewed as more of a failure in that railways used the legislation merely as a first-resort after "demarketing" a line, rather than a last-resort after trying to find a short line buyer. In November 1995 the federal government privatized CN, and in 1996, the government corrected the NTA 1987 shortfalls with the Canadian Transportation Act which more fully deregulates the railway industry.
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The AML1-ETO fusion protein ultimately causes transcriptional repression of the p14ARF gene, which deregulates the expression levels of Mdm2 and p53. The down regulation of ARF, increases Mdm2 levels due to the lack of regulation by the ARF gene. Unregulated, overexpressed Mdm2 will suppress p53 levels. The suppression of p53 levels is an anti-apoptotic mechanism for cancer cells to survive (Elagib, 2006, Weinberg, 2014).The fusion oncoprotein involves the gene AML1 (now known as RUNX1) and ETO (now known as RUNX1T1). AML1, located at the 21q22, normally has the ability to activate transcription of the ARF gene and ETO, located at the 8q22, normally has the ability to repress transcription. The fusion protein AML1-ETO is commonly found in acute myeloid leukemia patients. p14ARF is a well known tumor suppressor that serves as the safety net when p53 tumor suppressor's functions are inhibited.
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The complexity of the transcriptome, and our evolving understanding of its structure may inform a reinterpretation of the functional basis for many natural polymorphisms associated with disease states. Many SNPs associated with certain disease conditions are found within non-coding regions and the complex networks of non-coding transcription within these regions make it particularly difficult to elucidate the functional effects of polymorphisms. For example, a SNP both within the truncated form of ZFAT and the promoter of an antisense transcript increases the expression of ZFAT not through increasing the mRNA stability, but rather by repressing the expression of the antisense transcript. The ability of long ncRNAs to regulate associated protein-coding genes may contribute to disease if misexpression of a long ncRNA deregulates a protein coding gene with clinical significance. In similar manner, an antisense long ncRNA that regulates the expression of the sense BACE1 gene, a crucial enzyme in Alzheimer’s disease etiology, exhibits elevated expression in several regions of the brain in individuals with Alzheimer's disease Alteration of the expression of ncRNAs may also mediate changes at an epigenetic level to affect gene expression and contribute to disease aetiology.
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