150 Sentences With "causes pain" | Random Sentence Generator

The condition causes pain and tenderness just outside a joint.

Runner's knee causes pain and tenderness behind and around the kneecap.

Its venom causes pain and can alter heart rate and breathing.

When it swells, it pushes on the nerves, which causes pain.

But there are other ways in which loneliness causes pain, too.

"We know this verdict causes pain for many people," Greitens said.

He also causes pain where a president ought to try to heal.

And certainly not the presence of Noah, who only ever causes pain.

The condition causes pain, blurred vision, headaches, and even cause temporary blindness, Iwach said.

That damage in turn causes pain, swelling and changes in skin color and temperature.

But I was diagnosed with an autoimmune disease that causes pain and serious fatigue.

This makes your fascia rigid and stiff, which causes pain, tightness, or just dull soreness.

"Words have an influence; violence causes pain; hate can rip us apart," Judy Shepard said.

"Words have an influence; violence causes pain; hate can rip us apart," Shepard said in an ad.

The solution is very simple: If going heavy on certain exercises causes pain, just go light instead.

One that causes pain or chaos — perhaps a pressing issue that results in a loss of revenue.

Overuse inflames the tendons and their protective sheaths, which causes pain along the thumb side of the wrist.

And it can be very frustrating when something that's supposed to be pleasurable causes pain and discomfort instead.

For example, you might find that lifting heavy weights causes pain in your shoulders, elbows, knees, or wrists.

In endometriosis, which affects up to one in 222 women, abnormal growth of uterine tissue causes pain and disability.

The venom causes pain at the bite area, which then spreads to the chest, abdomen, or the entire body.

She had blood pressure spikes and developed sciatica, which causes pain that radiates to the lower back and legs.

This causes pain in a state and a country where centuries of racism have already left an open wound.

China is the world's biggest car market by a wide margin, so a nose-dive in sales causes pain.

All four autopsies showed an expansion of gas in the intestines, which causes pain and could result in a rupture.

Boiling them causes pain, the government said, and should be replaced by a more rapid method of death — such as stunning.

In cases where a tumor grows through the skin and causes pain or bleeding, of course, surgery becomes a palliative response.

Shale revolution reduces America's foreign oil needs US presidents typically try to avoid taking action that causes pain at the pump.

An air raid siren, which lies right above the threshold of when sound causes pain, clocks in at just over 120 db.

"The big thing that causes pain upon entry is vulvodynia or vestibular vulvitis, which causes chronic pain in the vulvar region," Minkin says.

The extensive intestinal inflammation suggested some kind of inflammatory bowel condition like Crohn's disease, an autoimmune disorder that causes pain and bloody diarrhea.

Johnson says the problem is Maher's not getting the message from black people that the word causes pain ... and she doesn't think he ever will.

"All these sorts of things that people say are childish and that we should ignore are still happening," Inoue said, "and it still causes pain."

Whether the information that gets to the brain causes pain depends on the balance of activity in small and large fibers coming through the gate.

When your IT band is overworked or tight, it literally rubs on your femur and gets inflamed, which causes pain on the outside of your knee.

While the carving's reminder of Confederate heroes causes pain, "It's not going to keep me from coming to the mountain," said Graves, a Stone Mountain resident.

"Today we take a step forward to raise awareness among the people about this type of practice that causes pain and suffering," Governor Rosselló said Wednesday.

"If the pain is deeper in the pelvis, the first thing we consider is endometriosis, because it's fairly common and usually causes pain during sex," Minkin says.

A paper came out recently showing how tarantula venom causes pain through this particular type of sodium channel, that we didn't think had anything to do with pain.

Tight races remain in three battlegrounds: Nevada, North Carolina and Ohio "Words have an influence, violence causes pain, hate can rip us apart," Shepard says looking into the camera.

The artist has talked about her struggles with fibromyalgia, a chronic musculoskeletal disease that causes pain and can also leave those suffering from it battling fatigue, headaches and insomnia.

Between 215% and 250% of patients will experience a complication known as postherpetic neuralgia, which causes pain and lasts from three months up to several years, once the shingles rash is gone.

But it causes pain for those on the the losing end — especially brick-and-mortar businesses that can't compete with Amazon's fast online deliveries, hard-to-beat prices and near-infinite variety.

"Any woman who has had sexual pain, but invariably those with lichen sclerosus, can develop a vicious cycle of vaginismus (pelvic floor contractions) which causes pain after their condition has been treated," says Frodsham.

I don't want to leave him untreated because that causes pain, but if I can't get enough to pay for his bill in two weeks, I don't know what I'm gonna be able to do.

Alaina, 23, Boston, MassachusettsI have multiple disabilities, but the major ones that cause pain are endometriosis and dyspraxia, which affects my balance, motor skills, and ability to walk—and sometimes causes pain as a result.

Recent medical research has proven otherwise, says Sven Eric Jordt, an assistant professor of anesthesiology at Duke University who specializes in sensory mechanisms "We discovered that the chemical causes pain by activating pain receptors," Jordt says.

But we know that Mr. Trump has bragged about underpaying contractors who he has said have done shoddy work and has cut workers' benefits and salaries, being cheap in a way that causes pain and suffering.

CURVEBALL COMING For a government, losing investment grade status causes pain because certain types of investors mandated only to buy high-grade debt usually big pension funds or 'passive' Exchange Traded Funds are then forced to sell.

GENEVA (Reuters) - Swiss voters have rejected a proposal to subsidize farmers who let the horns on their cows and goats grow rather than removing them with a red-hot iron in a procedure which critics say causes pain.

When House members voted on July 26, 85033 to ban all VA medical testing that causes pain to animals, specifically targeting VA's canine research program, it was the first step toward a complete devaluation of the lives of catastrophically injured veterans.

Unlike traditional prescription migraine medicines, which typically work to lessen the blood vessel expansion that causes pain but don't really hit at the underlying causes, CBD and THC treatments help to solve several different migraine-related problems in your body at once.

There's something called Finkelstein's test that indicates whether someone is at risk for de Quervain's"—an inflammatory disease that causes pain in the tendons in your thumb that extend down to the wrist—"and using that, we found a high number of positives.

He and his team promptly recognized Taylor's condition as complex regional pain syndrome, a misfiring within the peripheral and central nervous systems that causes pain signals to go into overdrive and stay turned on even after an initial injury or trauma has healed.

The 19-century German pessimist Arthur Schopenhauer was perhaps the first philosopher to draw attention to what he called the "diabolical" in his work "On Human Nature": For man is the only animal which causes pain to others without any further purpose than just to cause it.

He was gearing up to compete with the University of Georgia's track and field team when he was diagnosed with chronic exertional compartment syndrome – an exercise-induced muscle and nerve condition that causes, pain, swelling and sometimes disability of the ailing leg or arm, according to Minnesota's Mayo Clinic.

Read more:Women are saying they've been sickened by a mysterious 'breast implant illness' that causes pain, rashes, and nauseaBreast implant manufacturer Allergan just recalled one type of implant after hundreds of Americans developed a rare cancer linked to the devices17 celebrities who have spoken about their plastic surgeries

Though they haven't pinpointed the exact nature of the changes, the findings may lead to new ways of thinking about potentially debilitating health condition — for instance, people on long-duration bed rest or people who have a condition where fluid accumulates in ventricles in the brain and causes pain and pressure.

Read more:Women are saying they've been sickened by a mysterious 'breast implant illness' that causes pain, rashes, and nauseaBreast implant manufacturer Allergan just recalled one type of implant after hundreds of Americans developed a rare cancer linked to the devicesA woman had a celebratory photo shoot with her just-removed implants after years of 'breast implant illness.

"We want the F.D.A. to warn the public that Lasik injures eyes and causes pain, vision problems and other persistent problems that cannot be solved — and that you don't get these problems from glasses or contact lenses," said Dr. Waxler, a former chief of the diagnostic and surgical devices branch in the F.D.A.'s division of ophthalmic devices.

This is the same mechanism that causes pain in bowel obstructions. An obstruction of the biliary tract can result in jaundice, a yellowing of the skin and whites of the eyes.

Shanahan has Ehlers- Danlos syndrome, a genetic connective tissue disease that causes pain and impacts her ability to move. She was interviewed by the Science History Institute as part of their oral history project related to disabled scientists.

Barium oxide is an irritant. If it contacts the skin or the eyes or is inhaled it causes pain and redness. However, it is more dangerous when ingested. It can cause nausea and diarrhea, muscle paralysis, cardiac arrhythmia, and can cause death.

In addition to watching for lameness in the flexed limb, the examiner also looks for lameness in the standing, contralateral (opposite) limb. An increase in lameness associated with the contralateral limb can suggest certain causes pain, such as bilateral hock or carpal disease.

X-ray of shoulder osteoarthritis. Arthritis of the shoulder causes pain and loss of motion and use of the shoulder. X-rays of the shoulder show loss of the normal space between the ball and socket. X-ray can provide radiographic staging of shoulder osteoarthritis.

Symptoms of Winchester syndrome begin with the deterioration of bone within the hands and feet. This loss of bone causes pain and limited mobility. The abnormalities of the bone spread to other areas of the body, mostly the joints. This causes arthropathy: stiffening of the joints (contractures) and swollen joints.

Knee of a male with Osgood–Schlatter disease Osgood–Schlatter disease causes pain in the front lower part of the knee. This is usually at the ligament-bone junction of the patellar ligament and the tibial tuberosity.Çakmak, S., Tekin, L., & Akarsu, S. (2014). Long-term outcome of Osgood-Schlatter disease: not always favorable.

When she feels ill, Nate fears that she is pregnant and is attempting to trap him. She later collapses and is diagnosed with appendicitis. Her operation causes pain and she is required to take prescription medication to aid her recovery. Nate fears that Sophie will become hooked on the drugs once again.

It is a subjective symptom of pain in the affected knee when turning over in bed at night. Osteoarthritic pain is present with weightbearing, but the meniscal tear causes pain with a twisting motion of the knee as the meniscal fragment gets pinched, and the capsular attachment gets stretched causing the complaint of pain.

Pelvic girdle pain (abbreviated PGP) is a pregnancy discomfort that causes pain, instability and limitation of mobility and functioning in any of the three pelvic joints. PGP has a long history of recognition, mentioned by Hippocrates and later described in medical literature by Snelling.Pain In Childbearing, Key Issues In Management, Margaret Yerby, Lesley Page.

Transient synovitis causes pain in the hip, thigh, groin or knee on the affected side. There may be a limp (or abnormal crawling in infants) with or without pain. In small infants, the presenting complaint can be unexplained crying (for example, when changing a diaper). The condition is nearly always limited to one side.

In North America, after drainage, an abscess cavity is often packed, perhaps with cloth, in an attempt to protect the healing wound. However, evidence from emergency medicine literature reports that packing wounds after draining causes pain to the person and does not decrease the rate of recurrence, nor bring faster healing, or fewer physician visits.

Chicken eyeglasses are an alternative to beak trimming, which is the removal of approximately one-third of the beak by a cold or heated blade, or an infrared beam, usually when chicks are 1-day old. This is often effective in reducing pecking injuries, but causes pain and has significant effects on chicken welfare.

Injection of melittin into animals and humans causes pain sensation. It has strong surface effects on cell membranes causing pore- formation in epithelial cells and the destruction of red blood cells. Melittin also activates nociceptor (pain receptor) cells through a variety of mechanisms. Melittin can open thermal nociceptor TRPV1 channels via cyclooxygenase metabolites resulting in depolarization of nociceptor cells.

De Quervain's syndrome is a medical condition when the synovial sheath surrounding tendons in the first extensor tendon compartment becomes inflamed, so called tenosynovitis. The tendons of the abductor pollicis longus and the extensor pollicis brevis run narrower due to the thickening of the synovial sheath, which causes pain when extending and moving the thumb outward.

A sound that irritates or causes pain. Westminster International have also implemented this sonic factor, but they withheld the exact sound frequencies used. ;RMS Integrated Solutions Ltd. This subsidiary is a specialist provider of integrated low voltage systems throughout the UK, including Fire & Security Systems, alarms, CCTV, Structured Cabling, TV & Satellite Distribution and Wireless Data Distribution Technology.

They are also used for secondary dressing. Gauze dressing is made up of woven or non-woven fibres of cotton, rayon, and polyester. Gauze dressing are capable of absorbing discharge from wound but requires frequent changing. Excessive wound discharge would cause the gauze to adhere to the wound, thus causes pain when trying to remove the gauze from the wound.

Tertiapin is a compound of the honey bee venom (apitoxin) that causes pain and signs of inflammation around the sting, but a great number of stings can be lethal (LD50 is 18-22 stings per kg for humans). An anaphylactic shock can develop if a person has an allergy to the venom. In that case even one sting can be lethal.

Fake advertisements are in between the chapters, and sometimes short skits, such as the Sombrero Brothers. The fake advertisements are usually of products from Oxymoron with Victor the spokesperson promoting it. Each product is usually of low quality (contrary to what one may think) or causes pain in some way. The show's most unusual characteristic is its frequent breaking of the fourth wall.

The benefit for the perpetrator is that this kind of punishment causes pain without any lasting marks or, under all but the most extreme conditions, lasting damage to the subjects. In India this method of punishment is often referred to as the chair and was or is used in correcting juvenile delinquents. Also in other countries it was a commonly used punishment.

It is considered to be poisonous if ingested in large quantities, and causes pain and irritation in the mouth. The plant can cause contact dermatitis by touching of the following poisonous parts of the plant: bark, flowers, fruits, leaves, roots, stems, and seeds. Some other symptoms of being poisoned are inflammation, blistering from contact with fresh sap, vomiting, and diarrhea.

Dantrolene, although thought of primarily as a peripherally acting agent, is associated with CNS effects, whereas baclofen activity is strictly associated with the CNS. Muscle relaxants are thought to be useful in painful disorders based on the theory that pain induces spasm and spasm causes pain. However, considerable evidence contradicts this theory. In general, muscle relaxants are not approved by FDA for long-term use.

Valleix, François Louis Isidore Sociétés savantes de France He died in 1855 after contracting diphtheria from a sick child.Full text of "History of pediatrics" Archiv.org In 1834 he became a member of the Société anatomique de Paris. His name is associated with "Valleix's points", described as: various points in the course of a nerve, about which, applied pressure causes pain in cases of neuralgia.

The appendix may come into physical contact with the obturator internus muscle, which will be stretched when this maneuver is performed on the right leg. This causes pain and is evidence in support of an inflamed appendix. The principles of the obturator sign in the diagnosis of appendicitis are similar to that of the psoas sign. The appendix is commonly located in the retrocecal or pelvic region.

Dacryocystitis is an infection of the lacrimal sac, secondary to obstruction of the nasolacrimal duct at the junction of lacrimal sac. The term derives from the Greek dákryon (tear), cysta (sac), and -itis (inflammation). It causes pain, redness, and swelling over the inner aspect of the lower eyelid and epiphora. When nasolacrimal duct obstruction is secondary to a congenital barrier it is referred to as dacrocystocele.

Abadie's sign of tabes dorsalis is a medical sign of tabes dorsalis, a late consequence of neurosyphilis. It is elicited by compressing the Achilles tendon, which normally causes pain. A positive Abadie's sign is defined by the absence of pain. It may occur in any disease that damages the dorsal column–medial lemniscus pathway, which transmits sensory information from the periphery to the brain.

CTA is used also to identify arterial dissection, including aortic dissection in the aorta or its major branches. Arterial dissection is when the layers of the artery wall peel away from each other; this causes pain and can be life-threatening. CTA is a quick and non-invasive method of identifying dissections and can show the extent of the disease and if there is leakage.

The exact cause of Tarsal Tunnel Syndrome (TTS) can vary from patient to patient. However the same end result is true for all patients, the compression of the posterior tibial nerve and it branches as it travels around the medial malleolus causes pain and irritation for the patient.Low, Hu L., and George Stephenson. "These Boots Weren't Made for Walking: Tarsal Tunnel Syndrome." Canadian Medical Association Journal 176.10 (2007): 1415–416.

Ramsey Hunt's syndrome causes pain and small blisters in the ear on the same side as the palsy. Otitis media, trauma, or post-surgical complications may alternatively become apparent from history and physical examination. If there is a history of trauma, or a tumour is suspected, a CT scan or MRI may be used to clarify its impact. Blood tests or x-rays may be ordered depending on suspected causes.

Full-body or localized pain to the extremities (known as acroparesthesia) or gastrointestinal (GI) tract is common in patients with Fabry disease. This pain can increase over time. This acroparesthesia is believed to be related to the damage of peripheral nerve fibers that transmit pain. GI-tract pain is likely caused by accumulation of lipids in the small vasculature of the GI tract, which obstructs blood flow and causes pain.

When ingested, gastrointestinal symptoms can manifest within six hours; these symptoms do not always become apparent. Within two to five days of exposure to ricin, effects of ricin on the central nervous system, adrenal glands, kidneys, and liver appear. Ingestion of ricin causes pain, inflammation, and hemorrhage in the mucosal membranes of the gastrointestinal system. Gastrointestinal symptoms quickly progress to severe nausea, vomiting, diarrhea, and difficulty swallowing (dysphagia).

Pain with deep inspiration leading to termination of the breath while pressing on the right upper quadrant of the abdomen usually causes pain (Murphy's sign). Yellowing of the skin (jaundice) may occur but is often mild. Severe jaundice suggests another cause of symptoms such as choledocholithiasis. People who are old, have diabetes, chronic illness, or who are immunocompromised may have vague symptoms that may not include fever or localized tenderness.

Specifically, Donaldson focuses on how social relationships modulate mood and behavior. She tries to understand how losing a partner, social loss, causes pain and grief at the neural circuit level. One of the main techniques that Donaldson uses to probe neural activity, and its relation to specific genes and behaviors, is in vivo calcium imaging and she also develops novel genetic tools with which to study neural mechanisms in voles.

Her catchphrase was, "Just trying to be helpful!" Unlike her print character she actually gives helpful information, but it is sometimes misleading or told at the wrong time. She also causes pain to other clumsy Mr. Men and Little Misses such as Little Miss Calamity, Mr. Bump, Little Miss Whoops, and even Mr. Quiet. Little Miss Helpful speaks with a Texan accent in the US Dub and a Neutral English accent in the UK Dub.

A Urinary Tract Infection is an infection that involves any part of the urinary system, being the kidneys, urethra, bladder, or ureters. Although women are more susceptible to getting UTI's, men may also develop them. The infection causes pain while urinating, the urge to urinate often, and pelvic pain. UTIs may be caused by Escherichia coli, which as mentioned above, may be found in bodies of water at the time of beach advisories.

In 2014, animal activists released graphic undercover footage of monkeys being used for brain research in Germany, provoking a public outcry. The monkeys in the video were bloodied, obviously distressed, and some were left in cages without food or water to make them compliant with the experimental procedures. A 2009 German opinion poll found that 89% of Germans agreed that the European Union protection laws should forbid all animal testing that causes pain and suffering.

Septic arthritis most commonly causes pain, swelling and warmth at the affected joint. Therefore, those affected by septic arthritis will often refuse to use the extremity and prefer to hold the joint rigidly. Fever is also a symptom; however, it is less likely in older people. On physical examination, the septic joint should be ruled out of intra-articular (from inside the joint) or periarticular (around the joint such as bursa and skin) cause.

It causes pain by the pinching of the nipple, by the restriction of blood flow, and by the reintroduction of blood flow. Nipple clamps are used in some BDSM activities, such as breast torture. The main types of nipple clamps are the clothes-pin-style clamp, tweezer clamp, clover clamp, and piercing clamp, though any device that applies direct pressure can be used. Clamps are typically used in pairs and often connected by a chain.

When due to Lyme, it most typically causes facial palsy impairing blinking, smiling, and chewing in one or both sides of the face. It may also cause intermittent double vision. Lyme radiculopathy is an inflammation of spinal nerve roots that often causes pain and less often weakness, numbness, or altered sensation in the areas of the body served by nerves connected to the affected roots, e.g. limb(s) or part(s) of trunk.

It is positive when it causes pain. The FABER test should also be performed, this test involves flexing, abducting, and externally rotating the hip. The FABER test is useful when diagnosing concurrently with a labral pathology and is considered positive if the position elicits pain. Additional non-invasive ways to observe possible FAI is changes in gait that include a lower peak hip extension and internal rotation to compensate for bony growth.

Peripheral arterial disease resulting in necrosis of multiple toes The signs and symptoms of peripheral artery disease are based on the part of the body that is affected. About 66% of patients affected by PAD either do not have symptoms or have atypical symptoms. The most common presenting symptom is intermittent claudication, which causes pain and severe cramping when walking or exercising. The pain is usually located in the calf muscles of the affected leg and relieved by rest.

Breaking off an attachment causes pain that is deeply rooted in the need to belong. People experience a range of both positive and negative emotions; the strongest emotions linked to attachment and belongingness. Empirical evidence suggests that when individuals are accepted, welcomed, or included it leads those individuals to feel positive emotions such as happiness, elation, calm, and satisfaction. However, when individuals are rejected or excluded, they feel strong negative emotions such as anxiety, jealousy, depression, and grief.

The subject may then be tickled, sexually pleased or otherwise enticed to move uncontrollably. When performed with multiple submissive participants, a predicament bondage scenario may force one to choose a position that causes pain to the other whom they know and love. The dilemma of being able to spare a loved one pain by submitting to pain, or sparing oneself from pain by submitting another to it, is used in BDSM and power exchange play.Wiseman, Jay.

Osteochondritis dissecans (OCD or OD) is a joint disorder primarily of the subchondral bone in which cracks form in the articular cartilage and the underlying subchondral bone. OCD usually causes pain during and after sports. In later stages of the disorder there will be swelling of the affected joint which catches and locks during movement. Physical examination in the early stages does only show pain as symptom, in later stages there could be an effusion, tenderness, and a crackling sound with joint movement.

The presence of a fibroid does not mean that it needs to be removed. Removal is necessary when the fibroid causes pain or pressure, abnormal bleeding, or interferes with reproduction. The fibroids needed to be removed are typically large in size, or growing at certain locations such as bulging into the endometrial cavity causing significant cavity distortion. Treatment options for uterine fibroids include observation or medical therapy, such a GnRH agonist, hysterectomy, uterine artery embolization, and high-intensity focused ultrasound ablation.

Kyoko makes a contract with Kyubey, a messenger of magic; wishing for her father to obtain more followers. Her father goes insane when he learns this, killing the rest of the family and himself; leaving only Kyoko alive to mentally torment her. She decides to use her magic only for herself, since using it for others causes pain. Kyoko is initially introduced as an aggressive and self-centered magical girl, but adopts a sympathetic outlook after clashing with Sayaka Miki.

According to Jain text Sarvārthasiddhi, translates S.A. Jain, "that which causes pain and suffering to the living is not commendable, whether it refers to actual facts or not is immaterial". 3\. Asteya (Non-thieving)- According to Puruşārthasiddhyupāya: 4\. Brahmacharya- It means chastity for householders and celibacy in action, words & thoughts for ascetics. 5\. Aparigraha (Non- possession)- According to Jain texts, attachment to possessions (parigraha) is of two kinds: attachment to internal possessions (ābhyantara parigraha), and attachment to external possessions (bāhya parigraha).

Pathologic explanation: This maneuver elicits tenderness in the right lower abdomen, because contents of the left lower abdomen are shifted upon application of pressure, further irritating the inflamed peritoneum. A Rovsing's sign is elicited by pushing on the abdomen far away from the appendix in the left lower quadrant. The appendix, in a large majority of people, is located in the right lower quadrant. While this maneuver stretches the entire peritoneal lining, it only causes pain in any location where the peritoneum is irritating the muscle.

Use of chemicals can be completely avoided if pressure shoeing is also used. This process involves placing some type of hard foreign object (such as a small piece of wood, stone, hard acrylic, or sharp object such as a tack or nail) against the sole of the horse's foot before applying the horseshoe and pads. It can also be done by trimming down the horse's hoof to its sensitive structures, then shoeing. Either method causes pain when the horse places its foot on the ground.

Cells in the dental pulp trigger an immune response from the invasion of foreign microorganisms. The inflammation of the pulp is a side effect of the immune response and causes pain. Pulpitis can often create so much pressure on the tooth nerve that the individual will have trouble locating the source of the pain, confusing it with neighboring teeth, called referred pain. The pulp cavity inherently provides the body with an immune system response challenge, which makes it very difficult for a bacterial infection to be eliminated.

Han Su-yeong (born 1967) is a South Korean writer. Her works have repeated images representing verticality such as falling, a roof, a bird’s eye view or bungee jumping. In her writings, the poor and sick people seek for a way to go up and to be recovered but they only face tragic outcomes because they cannot go against the reality where power flows from top to bottom. She tries to explore what causes pain by illustrating in detail the situations these people encounter.

Latrotoxin (α-Latrotoxin) found in venom of widow spiders also affects the neuromuscular junction by causing the release of acetylcholine from the presynaptic cell. Mechanisms of action include binding to receptors on the presynaptic cell activating the IP3/DAG pathway and release of calcium from intracellular stores and pore formation resulting in influx of calcium ions directly. Either mechanism causes increased calcium in presynaptic cell, which then leads to release of synaptic vesicles of acetylcholine. Latrotoxin causes pain, muscle contraction and if untreated potentially paralysis and death.

There are concerns that angling causes pain in fish. Given that some have interpreted the existing scientific information to suggest that fish may feel pain, it has been suggested that precautionary principles should be applied to commercial fishing, which would likely have multiple consequences. Both scientists and animal protection advocates have raised concerns about the possible suffering (pain and fear) of fish caused by angling. Other societal implications of fish experiencing pain include acute and chronic exposure to pollutants, commercial and sporting fisheries (e.g.

The onset is not dramatic. When the boot or shoes are taken off, there is a cramp-like pain in the affected forefoot, and moderate local edema appears on the dorsal aspect. On moving each toe in turn, that of the involved metatarsal causes pain, and when the bone is palpated from the dorsal surface, a point of tenderness is found directly over the lesion. Radiography at this stage is negative, but the condition is diagnosed correctly by military surgeons without the aid of x-rays.

In his thirties, he doesn't take life seriously, but his antics bring pain and tragic consequences to friends and family. He is sexually liberated and has sex with a stranger (Dawn Greenhalgh) on a train and his carelessness at work causes pain for his best friend and co-worker (Frank Converse). The Rowdyman was filmed in Corner Brook and St. John's, and is regarded as one of the best films about life in Newfoundland. It was featured in the Canadian Cinema television series which aired on CBC Television in 1974.

If they spend them too quickly, the Others can use the feelings and emotions of the humans surrounding them to recharge their powers. The Dark Others use negative emotions such as pain or anger, the Light Others use positive emotions such as joy. Feeding on pain causes pain to increase, feeding on joy causes joy to wane. Because negative emotions are much easier to achieve in humans, this arrangement creates a situation where the powers of the Dark Others are easier to recharge and are much more readily available than those of the Light Others.

Unlike other forms of ear infections, the pain of acute external otitis is worsened when the outer ear is touched or pulled gently. Pushing the tragus, the tablike portion of the auricle that projects out just in front of the ear canal opening, also typically causes pain in this condition as to be diagnostic of external otitis on physical examination. People may also experience ear discharge and itchiness. When enough swelling and discharge in the ear canal is present to block the opening, external otitis may cause temporary conductive hearing loss.

The second season of the American television drama series Sin senos sí hay paraíso, comprising 87 episodes, aired on Telemundo from 25 July 2017 to 28 November 2017. The show was broadcast from Monday to Friday at 9pm/8c. The second season revolves around Catalina Santana, who becomes an undercover agent of the DEA and changes her name to Virginia Fernández after pretending to be dead for 20 years. Catalina returns to Colombia to protect her family from Las Diablas, but her return only causes pain, disappointment, and tragedy for her mother.

Barry's conflict with the speed cult culminates in the death of their new leader who was attempting to avenge Savitar's death. It causes pain once again to all the speedsters, though Wally West manages to catch a glimpse of Allen directly afterwards, and sees him as the new Black Flash. When he realizes that his presence could damage or kill other innocents, Barry flees back into the Speed Force, where he encounters old friends Johnny Quick and Max Mercury. Max attempts to tell Allen that his becoming the Black Flash is not his fault.

It has been suggested as early as 4th century BC that pain and pleasure occurs on a continuum. Aristotle claims this antagonistic relationship in his Rhetoric: :::"We may lay it down that Pleasure is a movement, a movement by which the soul as a whole is consciously brought into its normal state of being; and that Pain is the opposite." He describes pain and pleasure very much like a push-pull concept; human beings will move towards something that causes pleasure and will move away from something that causes pain.

Illustration depicting a surgical discectomy A discectomy (also called open discectomy, if done through a 1/2 inch or larger skin opening) is the surgical removal of abnormal disc material that presses on a nerve root or the spinal cord. The procedure involves removing a portion of an intervertebral disc, which causes pain, weakness or numbness by stressing the spinal cord or radiating nerves. The traditional open discectomy, or Love's technique, was published by Ross and Love in 1971. Advances have produced visualization improvements to traditional discectomy procedures (e.g.

Potentially painful cancer treatments include immunotherapy which may produce joint or muscle pain; radiotherapy, which can cause skin reactions, enteritis, fibrosis, myelopathy, bone necrosis, neuropathy or plexopathy; chemotherapy, often associated with mucositis, joint pain, muscle pain, peripheral neuropathy and abdominal pain due to diarrhea or constipation; hormone therapy, which sometimes causes pain flares; targeted therapies, such as trastuzumab and rituximab, which can cause muscle, joint or chest pain; angiogenesis inhibitors like bevacizumab, known to sometimes cause bone pain; and surgery, which may produce post-operative pain, post-amputation pain or pelvic floor myalgia.

This contact may gradually damage the draining function of the meshwork until it fails to keep pace with aqueous production, and the intraocular pressure rises. The onset of symptoms is sudden and causes pain and other symptoms that are noticeable; it is treated as a medical emergency. Unlike open-angle glaucoma, angle-closure glaucoma is a result of the angle between the iris and cornea closing. This tends to occur in the far-sighted, who have smaller-than-normal anterior chambers, making physical contact between the iris and trabecular meshwork more likely.

Karen finds the peddler and asks for more information on where he found the doll. As the peddler attempts to sexually assault her, Mike rescues her, and the pair forces the peddler to admit he took the doll from the demolished toy store. Karen again tries to convince Mike that the doll is alive, but he refuses to believe her, insisting that he killed Charles Lee Ray. After driving Karen home, Mike is attacked by Chucky, and in the ensuing fight, Chucky is shot, and his wound inexplicably bleeds and causes pain.

Many people are unwell before breaking a hip; it is common for the break to have been caused by a fall due to some illness, especially in the elderly. Nevertheless, the stress of the injury, and a likely surgery, increases the risk of medical illness including heart attack, stroke, and chest infection. Hip fracture patients are at considerable risk for thromboemoblism, blood clots that dislodge and travel in the bloodstream. Deep venous thrombosis (DVT) is when the blood in the leg veins clots and causes pain and swelling.

A centipede bite is an injury resulting from the action of a centipede's forcipules, stinger-like appendages that pierce the skin and inject venom into the wound. Such a wound is not strictly speaking a bite, as the forcipules are a modified first pair of legs rather than true mouthparts. Clinically, the wound is viewed as a cutaneous condition characterized by paired hemorrhagic marks that form a chevron shape caused by the paired forcipules. The centipede's venom causes pain and swelling in the area of the bite, and may cause other reactions throughout the body.

If the ligaments that attach the phalanx (bone of the toe) to the metatarsal bone are impacted, the resulting inflammation may put pressure on an otherwise healthy nerve and produce neuroma-type symptoms. Additionally, an intermetatarsal bursitis between the third and fourth metatarsal bones will also give neuroma-type symptoms because it too puts pressure on the nerve. Freiberg disease, which is an osteochondritis of the metatarsal head, causes pain on weight-bearing or compression. Other conditions that could be clinically confused with a neuroma include stress fractures/reactions and plantar plate disruption.

Pelagia noctiluca may strand in large numbers, as shown on this beach in Tunisia P. noctiluca is considered the most important stinging jellyfish in the Mediterranean Sea. Both its tentacles and—unusual among jellyfish—the bell are covered in cnidocytes (stinging cells), and even recently dead, stranded individuals can sting. The sting causes pain that typically lasts 1–2 weeks, local redness, swelling and a rash, but it is generally not dangerous and there are no known fatalities. On occasion, symptoms may be more general and include dizziness, vomiting and diarrhea.

The condition is often not detected until it has fully developed and is causing pain. The pain is usually concentrated around the cervical region of the neck, shoulder, and lower spine, with downward-moving, stinging pain. Types of spondylitis include cervical spondylitis, which affects the cervical spine, causing pain to spread to the back of the neck; lumbar spondylitis, which causes pain in the lumbar region; and ankylosing spondylitis, which is primarily a disease that affects the sacroiliac joints, causing stiffness in the neck, jaw, shoulders, hips and knees.

Mika's hatred of Kazuya originated during her early teens, when he deliberately stole a girl she liked to hurt his sister's feelings. :Before her death, she entrusted Himiko (despite her hostility towards her) to rescue Kaon from Kazuya, giving her the key to a device she created based on plans drawn up by her grandfather (Reitarō). The device, a cello capable of creating a harmony to suppress Mana, causes pain to an Absolute Angel or Kazuya. ; : :Kaon (also known as "Kaon of the Lunar Spiral") is the Absolute Angel Murakumo, a reference to Ame no Murakamo in Kannazuki no Miko.

One of the most common side effects of subcutaneous administration is moderate to severe pain at the injection site. Although the manufacturer recommends keeping maropitant at room temperature, many people have noted that keeping it in the fridge reduces the sting upon injection. Only unbound maropitant causes pain – it is normally formulated with beta-cyclodextrin to increase solubility; at cooler temperatures, more of the maropitant remains bound to the cyclodextrin, leaving less maropitant unbound. While there is no pain related to the intravenous administration of maropitant, pushing a dose in too quickly can temporarily reduce blood pressure.

Tepoxalin (C20H20ClN3O3) is produced by the condensation of a carboxyl group of 3-[5-(4-chlorophenyl)-1-(4-methoxyphenyl)pyrazol-3-yl] propanoic acid and an amino group of N-methylhydroxylamine. Condensation is a chemical reaction in which two or more molecules merge into form a larger molecule, with the simultaneous loss of a small molecule such as water or methanol. The drug works as a nonsteroidal anti-inflammatory drug (NSAID) to suppress both cyclooxygenase and lipoxygenase. Cyclooxygenase and lipoxygenase produces COX-2 and 5-LOX enzymes respectively, these enzymes activate the swelling and inflammation that causes pain in animals.

In the summer of 1980, introverted bookworm Colin Jacobs moves to Santa Leona, California with his mother, and soon meets and becomes friends with another boy his age. Roy Borden is everything Colin has never been, but secretly wishes he could be- brave, outgoing, muscular, athletically talented and a consummate ladies' man. He is an instinctive fighter, ready to stand up to anyone or anything- a stark contrast to Colin, who "learned long ago that resistance causes pain" and avoids trouble and confrontations. Despite their differences, Roy appears glad to be friends with Colin, even remarking that the boys and girls who think they are his friends are really just "acquaintances".

In the book, Dick-Read defined the term as the absence of any intervention that would otherwise disturb the sequence of labor. The book argued that because of "civilized" British women fear birth the birthrate was dropping, and if women were not to fear birth, birthing would be easier since fear creates tension which, in turn, causes pain. In 1942, Dick-Read published Revelation of Childbirth (which was later retitled Childbirth without Fear), advocating natural childbirth, which became an international bestseller. In the late 1940s, he brought his ideas to America, but saw similar ideas with differing names – “pain-free birth” and “prepared childbirth” – were already gaining traction.

Prior to dissection for educational purposes, chloroform was administered to this common sand frog to induce anesthesia and death. The extent to which animal testing causes pain and suffering, and the capacity of animals to experience and comprehend them, is the subject of much debate. According to the USDA, in 2016 501,560 animals (61%) (not including rats, mice, birds, or invertebrates) were used in procedures that did not include more than momentary pain or distress. 247,882 (31%) animals were used in procedures in which pain or distress was relieved by anesthesia, while 71,370 (9%) were used in studies that would cause pain or distress that would not be relieved.

All candidates for rhizotomy must have good muscle strength in the legs and trunk. There must also be evidence of adequate motor control, or the ability to make reciprocal movements for crawling or walking, and to move reasonably quickly from one posture to another. Chiefly, pediatric rhizotomy candidates are people with CP who have shown age-appropriate progression in motor development, but spasticity hampers the development of skills and/or causes gait patterns like the scissors gait. In adults, the primary requirements are that the person is able to ambulate independently, but spasticity limits energy, flexibility, walking speed and balance and sometimes causes pain/muscle spasms.

In humans, disease is often used more broadly to refer to any condition that causes pain, dysfunction, distress, social problems, or death to the person afflicted, or similar problems for those in contact with the person. In this broader sense, it sometimes includes injuries, disabilities, disorders, syndromes, infections, isolated symptoms, deviant behaviors, and atypical variations of structure and function, while in other contexts and for other purposes these may be considered distinguishable categories. Diseases can affect people not only physically, but also mentally, as contracting and living with a disease can alter the affected person's perspective on life. Death due to disease is called death by natural causes.

Whether beak trimming causes pain is a hotly debated concern. It is a complex issue as it may involve acute and/or chronic pain, and depends on the age it is performed, the method of trimming and the length of beak that is removed. Beak trimming in the poultry industry usually occurs without anaesthetic at 1-day of age or when the chicks are very young, but can occur at a later age if an outbreak of feather pecking occurs, and in some cases, birds may be beak trimmed on repeated occasions. Beak trimming is not permitted in the UK on meat chickens that are aged over 10 days.

At these doses, levels of progesterone remain elevated above baseline for at least 48 hours (6 ng/mL at this point for 100 mg), with an elimination half-life of about 22 hours. Due to the high concentrations achieved, progesterone by intramuscular injection at the usual clinical dose range is able to suppress gonadotropin secretion from the pituitary gland, demonstrating antigonadotropic efficacy (and therefore suppression of gonadal sex steroid production). Intramuscular progesterone often causes pain when injected. It irritates tissues and is associated with injection site reactions such as changes in skin color, pain, redness, transient indurations (due to inflammation), ecchymosis (bruising/discoloration), and others.

Bladder distension while under general anesthesia, also known as hydrodistention (a procedure which stretches the bladder capacity), has shown some success in reducing urinary frequency and giving short-term pain relief to those with IC. However, it is unknown exactly how this procedure causes pain relief. Recent studies show pressure on pelvic trigger points can relieve symptoms. The relief achieved by bladder distensions is only temporary (weeks or months), so is not viable as a long-term treatment for IC/BPS. The proportion of people with IC/BPS who experience relief from hydrodistention is currently unknown and evidence for this modality is limited by a lack of properly controlled studies.

The Anti-Defamation League was one of the organizations signing a letter to broadcasters urging them to avoid using the name. The Religious Action Center of Reform Judaism also advocates a name change. In 2013 a group of 61 religious leaders in Washington, D.C., sent a letter to NFL Commissioner Roger Goodell and team owner Dan Snyder stating their moral obligation to join the Change the Mascot movement due to the offensive and inappropriate nature of the name which causes pain whether or not that is intended. In June 2015, the United Church of Christ General Synod passed a resolution calling for a stop to using images or mascots that could be demeaning to the Native American community.

Shunning is often used as a pejorative term to describe any organizationally mandated disassociation, and has acquired a connotation of abuse and relational aggression. This is due to the sometimes extreme damage caused by its disruption to normal relationships between individuals, such as friendships and family relations. Disruption of established relationships certainly causes pain, which is at least an unintended consequence of the practices described here, though it may also in many cases be an intended, coercive consequence. This pain, especially when seen as unjustly inflicted, can have secondary general psychological effects on self-worth and self-confidence, trust and trustworthiness, and can, as with other types of trauma, impair psychological function.

The moral categories, good and evil, are intimately connected with desire, though not in the way commonly supposed. Man does not desire a thing because he thinks it is good, or shun it because he considers it bad; rather he considers anything good if he desires it, and regards it as bad if he has an aversion for it. Now whatever is felt to heighten vital activity gives pleasure; whatever is felt to lower such activity causes pain. Pleasure coupled with a consciousness of its external cause is called love, and pain coupled with a consciousness of its external cause is called hate — "love" and "hate" being used in the wide sense of "like" and "dislike".

A young country spider Itsy befriends Leslie McGroarty, a perky young city girl who takes piano lessons from the music teacher (incidentally, she learns to play the real rhyme) and her cat, Langston. When Itsy frightens the teacher, she calls the Exterminator, who tries to kill Itsy with the toxic machine blower, but it causes pain and destruction to the instructor's house, and the Exterminator turns out to be a heavily armed android. The Exterminator's method uses more extreme weapons, escalating from poison and vacuums to guns and explosives, and it destroys the instructor's house. Itsy finally reunites with Leslie (who senses to leave the house when the Exterminator uses the weapons) and head home to the big city with the bicycle.

The cave's magical protection included a door that could only be opened with a blood offering, an enchanted boat, a basin of potion that causes pain and horrific visions to the drinker, and the use of Inferi. Dumbledore and Harry Potter pursued the locket in The Half- Blood Prince only to find a fake one at the bottom of the basin. Disillusioned Death Eater Regulus Black had learned about the Horcrux and its hiding place from his house elf Kreacher, whom he had originally volunteered to accompany Voldemort to hide the Horcrux. In an effort to bring about Voldemort's eventual downfall, he and Kreacher navigated the magical protection and stole the locket, replacing it with the false one to fool Voldemort.

Epidural lysis of adhesions (LOA), also known as percutaneous adhesiolysis or the Racz procedure, is a minimally invasive spine surgery which involves the dissolution of epidural scar tissue by mechanical means to facilitate the spread of analgesics in an effort to alleviate pain. It is a type of percutaneous adhesiolysis procedure commonly used to treat chronic pain resulting from failed back surgery syndrome wherein scar tissue has formed around the nerves and causes pain. Evidence suggests the procedure may also be effective in treating spinal stenosis and radicular pain caused by a herniated disc. (Sometimes hyaluronidase (an enzyme) is also injected to dissolve the adhesions.) It was developed at Texas Tech University Health Sciences Center (TTUHSC) in 1989 by Gabor B. Racz.

In 1992, the Central Conference of American Rabbis issued a resolution calling for the end of sports teams names that promote racism, in particular the Atlanta Braves and the Washington Redskins. In 2001, the Unitarian Universalist Association passed a resolution to establish relationships with groups working to end the use of Indian images and symbols for sports and media mascots. In 2004, the United Methodist Church also passed a resolution condemning the use of Native American team names and sports mascots, which was highlighted in a meeting of the Black caucus of that organization in 2007. A group of sixty-one religious leaders in Washington, D.C. sent a letter to NFL Commissioner Roger Goodell and Redskins owner Daniel Snyder stating their moral obligation to join the "Change the Mascot" movement due to the offensive and inappropriate nature of the name which causes pain whether or not that is intended.

Padmasana, one of the ancient seated meditation asanas Patanjali begins discussion of Āsana (आसन, posture, seat) by defining it in verse 46 of Book 2, as follows,The Yoga Philosophy TR Tatya (Translator), with Bhojaraja commentary; Harvard University Archives; The Yoga-darsana: The sutras of Patanjali with the Bhasya of Vyasa GN Jha (Translator), with notes; Harvard University Archives; The Yogasutras of Patanjali Charles Johnston (Translator) Asana is a posture that one can hold for a period of time, staying relaxed, steady, comfortable and motionless. The Yoga Sutra does not list any specific asana.The Yoga-darsana: The sutras of Patanjali with the Bhasya of Vyasa GN Jha (Translator); Harvard University Archives, page xii Āraṇya translates verse II.47 of Yoga sutra as, "asanas are perfected over time by relaxation of effort with meditation on the infinite"; this combination and practice stops the quivering of body.Hariharānanda Āraṇya (1983), Yoga Philosophy of Patanjali, State University of New York Press, , page 229 Any posture that causes pain or restlessness is not a yogic posture.

This characterization in this text, states Olivelle, is an attempt to create revulsion for a woman's body in the mind of an ascetic who has sworn to a celibate lifestyle, and similar characterization is also found in Buddhism and Jainism texts.Patrick Olivelle (2011), Ascetics and Brahmins: Studies in Ideologies and Institutions, Anthem, , pages 114, 178-181 with footnotes; For a comparison of monastic traditions and the ascetic views on women, see Karma Lekshe Tsomo (2004), Buddhist Women and Social Justice: Ideals, Challenges, and Achievements, State University of New York Press, , pages 55-67 The Yajnavalkya Upanishad, similarly, calls the desire for son as vain.Patrick Olivelle (2011), Ascetics and Brahmins: Studies in Ideologies and Institutions, Anthem, , pages 111-112 with footnotes He causes pain to his parents by miscarriage, in delivery, then through illnesses. The text depicts how boys tend to fall for mischief, go to Gurukul but may not learn, commit adultery and other sins in their youth, become penniless, grow old into sorrow and suffer the vicissitudes of life.

In the Pali Canon, sacca is frequently found in the term ariya-sacca, meaning "noble truth" or "truth of the noble ones".See, for instance, Harvey (2007), in his "Glossary and Commentary" section's explanation of "Reality for the Noble One(s) (or, for the Noble One(s), a reality)". More specifically, the term ariya-sacca refers to the Buddha's "Four Noble Truths," elucidated in his first discourse as follows (where sacca is translated as "reality"): > Now this, bhikkhus, is the Truth about pain: birth is painful, aging is > painful, illness is painful, death is painful; sorrow, lamentation, physical > pain, unhappiness and distress are painful; union with what is disliked is > painful; separation from what is liked is painful; not to get what one wants > is painful; in brief, the five bundles of grasping-fuel are painful. Now > this, bhikkhus, is the Truth about that which causes pain: It is this > craving which leads to renewed existence, accompanied by delight and > attachment, seeking delight now here now there; that is, craving for sense- > pleasures, craving for existence, craving for extermination (of what is not > liked).