Catabasis Pharmaceuticals is focused on amyotrophic lateral sclerosis and other terrible neurological conditions.
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Sarepta said last week it would collaborate with Catabasis Pharmaceuticals Inc to explore a combination DMD treatment approach.
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Shares of Sarepta, which has announced DMD collaborations with Catabasis Pharmaceuticals Inc and Summit Therapeutics Plc, have more than doubled since the FDA announced its approval on Sept. 19.
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Catabasis Pharmaceuticals, founded in 2008 and based in Cambridge, Massachusetts, is a clinical-stage biopharmaceutical company. At Catabasis Pharmaceuticals, the company’s mission is to bring hope and life-changing therapies to patients and their families. Their lead program is edasalonexent, an NF-kB inhibitor in development for the treatment of Duchenne muscular dystrophy. The global Phase 3 PolarisDMD trial for edasalonexent is enrolling boys affected by Duchenne . In Catabasis’s Phase 2 MoveDMD clinical trial and open-label extension, edasalonexent was shown to preserve muscle function as assessed by the North Star Ambulatory Assessment and Timed Function Tests compared with the rate of change during an off-treatment control period.
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Katabasis or catabasis (, from "down" and "go") is a descent of some type, such as moving downhill, the sinking of the winds or sun, a military retreat, a trip to the underworld, or a trip from the interior of a country down to the coast. The term has multiple related meanings in poetry, rhetoric, and modern psychology.
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In modern psychology, the term katabasis is sometimes used to describe the depression some young men experience.Jung's 1932 Article on Picasso Author Robert Bly proposes in his book Iron John: A Book About Men several reasons for the "catabasis phenomenon", amongst them the lack of Western initiation rites and the lack of strong father figures and role models.
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7), dated to the late 3rd or early 4th century CE, Hecate Ereschigal is invoked against fear of punishment in the afterlife.Hans Dieter Betz, "Fragments from a Catabasis Ritual in a Greek Magical Papyrus", History of Religions 19,4 (May 1980):287–295). The goddess appears as Hecate Ereschigal only in the heading: in the spell itself only Erschigal is called upon with protective magical words and gestures.
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Andrea da Barberino also produced a prose "romanzo" called Storia di Ugone d'Alvernia in Tuscan prose (in five known manuscripts) where, during the narration of the infernal catabasis written in terzine, the prose functions as a gloss, appearing between poetic lines to clarify meanings details.M. G. Scattolini, Appunti sulla tradizione dell’Ugone d’Alvernia,Rassegna europea di letteratura italiana, 36 (2010), pp. 25-42 Andrea da Barberino. Storia d'Ugone d'Alvernia.
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Another major retelling, also in Latin, is the long unfinished poem De raptu Proserpinae ("On the Abduction of Proserpina") by Claudian (d. 404 AD). Ovid uses the name Dis, not Pluto in these two passages,In Book 6 of the Aeneid (the catabasis of Aeneas), Vergil also names the ruler of the underworld more often as Dis than Pluto. and Claudian uses Pluto only once; translators and editors, however, sometimes supply the more familiar "Pluto" when other epithets appear in the source text.
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See also Smith's Dictionary of Greek and Roman Biography and Mythology, entry on "Charon" online for placement in the mouth, though archaeology disproves Smith's statement that every corpse was given a coin; see article on Charon's obol. Some authors say that those who could not pay the fee, or those whose bodies were left unburied, had to wander the shores for one hundred years, until they were allowed to cross the river.Virgil, Aeneid 6, 324–330. In the catabasis mytheme, heroes – such as Aeneas, Dionysus, Heracles, Hermes, Odysseus, Orpheus, Pirithous, Psyche, Theseus and Sisyphus – journey to the underworld and return, still alive, conveyed by the boat of Charon.
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This led to regulatory certainty and acceptance when Biogen opened a lab in 1982, in contrast to the hostility that caused the Genetic Institute (a Harvard spinoff) to abandon Somerville and Boston for Cambridge. The biotech and pharmaceutical industries have since thrived in Cambridge, which now includes headquarters for Biogen and Genzyme; laboratories for Novartis, Teva, Takeda, Alnylam, Ironwood, Catabasis, Moderna Therapeutics, Editas Medicine; support companies such as Cytel; and many smaller companies. By the end of the 20th century, Cambridge had one of the most costly housing markets in the Northeastern United States. While considerable class, race, and age diversity persisted, it became harder for those who grew up in the city to afford to stay.
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In another, Neith sees the 5th century alchemist lover of Augustine of Hippo, Athenais Karthagonensis, as she endeavors to uncover the secrets of a chamber that could lead to the fabled Alcahest following the death of her son. In yet another, Neith sees Ethiopian painter Berihun Bekele, who lives in London in the early 21st century and assists his granddaughter Annie with the development of a video game, Witnessed, that bears striking resemblance to Neith's actual world. Each narrative seems to share elements with the others, allowing each to flow into the other. The concepts of catabasis, a journey to the underworld like that of Orpheus in Greek myth, and apocatastasis, a sort of rebirth, in particular are repeatedly emphasized.
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Contrary to popular etiology there is little evidence to connect the myth of Charon to the custom of placing a pair of coins on the eyes of the deceased, though the larger gold-foil coverings discussed above might include pieces shaped for the eyes. Pairs of coins are sometimes found in burials, including cremation urns; among the collections of the British Museum is an urn from Athens, ca. 300 BC, that contained cremated remains, two obols, and a terracotta figure of a mourning siren.British Museum, "Terracotta funerary urn." Ancient Greek and Latin literary sources, however, mention a pair of coins only when a return trip is anticipated, as in the case of Psyche’s catabasis, and never in regard to sealing the eyes.
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