Autopsy reports typically indicate that the jumpers have lacerated aortas, livers, spleens, and hearts.
|
|
It feels like Slash is plucking the guitar solo to "November Rain" on my ventricles and aortas.
|
|
Dr. DeBakey and Dr. Cooley devised operations to repair potentially fatal bulges in aortas and to bypass arteriosclerotic damage in neck and leg arteries that could lead to strokes.
|
|
And then they turned out to not be my friends at all and to, in fact, still be carrying toxicity, pulsing through their veins and gushing in and out of their wizened aortas.
|
|
This was a dense Sunday, and it's been a bit of a week, so things did go on autopilot here and there, but I really liked a lot of the cluing for little guys like ALI, AORTAS, NAE and SEGUE.
|
|
Erste Abteilung. Originale 35(3):352-357. both isolated from Water buffalo aortas.
|
|
Compared to normal aortas, aneurysmal aortas have a much higher volume fraction of collagen and ground substance (54.8% vs. 95.6%) and a much lower volume fraction of elastin (22.7% vs. 2.4%) and smooth muscles (22.6% vs. 2.2%), which contribute to higher initial stiffness.
|
|
The two aortas are connected by a number of vessels, one passing through each of the gills. Amphibians also retain the fifth connecting vessel, so that the aorta has two parallel arches.
|
|
Mutations in the genes TGFBR 1 and 2 are known to cause dissections in aortas with normal diameter size (>4.3 cm) and gene FPN1 mutations typically affect aortas with larger diameters (<4.4 cm). There are several hypotheses which attempt to explain how the dissection physically occurs. The first states that a tear develops in the intima layer of the aorta which allows blood to flow from the lumen of the aorta into the intima. This event creates a dissection and essentially two lumens.
|
|
Lowi was just shot in the hand, but one of Cohn's aortas was nicked, and he almost died, requiring of blood. Earlier that week Hunt had attended a rally for antisemitic and white supremacist politician John G. Crommelin, and had had a fight with a Jewish boy over a chess game at the Gadsden Community Centre.
|
|
This is made possible by a muscular ridge that subdivides the ventricle during ventricular diastole and completely divides it during ventricular systole. Because of this ridge, some of these squamates are capable of producing ventricular pressure differentials that are equivalent to those seen in mammalian and avian hearts. Crocodilians have an anatomically four-chambered heart, similar to birds, but also have two systemic aortas and are therefore capable of bypassing their pulmonary circulation.
|
|
All amniotes have a broadly similar arrangement to that of humans, albeit with a number of individual variations. In fish, however, there are two separate vessels referred to as aortas. The ventral aorta carries de-oxygenated blood from the heart to the gills; part of this vessel forms the ascending aorta in tetrapods (the remainder forms the pulmonary artery). A second, dorsal aorta carries oxygenated blood from the gills to the rest of the body and is homologous with the descending aorta of tetrapods.
|
|
This bulge is the result of the creation of a false lumen due to the vast amount of blood seepage from the aortas and surrounding veins. In some cases it is not uncommon to see degeneration in the ascending and descending aorta and the atrioventricular and semilunar valves due to elastolysis or breakdown and loss of elastic fibers. These connective tissue malfunctions are traceable to mutations, and lack of genes encoding for important components such as collagens, and micro- fibril-associated glycoproteins. Breakdown among these connective layers eventually compromises the integrity of the aortic lumen.
|
|
Confocal microscopy photographs of the descending aortas of two 15-month-old progeria mice, one untreated (left) and the other treated with the FTI drug tipifarnib (right) Untreated cells from children with the genetic disease progeria (left) compared to similar cells treated with FTIs A mouse model of progeria exists, though in the mouse, the LMNA prelamin A is not mutated. Instead, ZMPSTE24, the specific protease that is required to remove the C-terminus of prelamin A, is missing. Both cases result in the buildup of farnesylated prelamin A on the nuclear membrane and in the characteristic nuclear LMNA blebbing. Fong et al.
|
|
The classical findings on a chest X-ray will be widened mediastinum, apical cap, and displacement of the trachea, left main bronchus, or nasogastric tube. A normal chest x-ray does not exclude transection, but will diagnose conditions such as pneumothorax or hydrothorax. The aorta may also be torn at the point where it is connected to the heart. The aorta may be completely torn away from the heart, but patients with such injuries rarely survive very long after the injury; thus it is much more common for hospital staff to treat patients with partially torn aortas.
|
|
Confocal microscopy photographs of the descending aortas of two 15-month-old progeria mice, one untreated (left picture) and the other treated with the farnsyltransferase inhibitor drug tipifarnib (right picture). The microphotographs show prevention of the vascular smooth muscle cell loss that is otherwise rampant by this age. Staining was smooth muscle alpha-actin (green), lamins A/C (red) and DAPI (blue). (Original magnification, ×40) It was shown on a mouse model of Hutchinson–Gilford progeria syndrome that dose-dependent administration of tipifarnib can significantly prevent both the onset of the cardiovascular phenotype as well as the late progression of existing cardiovascular disease.
|
|
In 1960 Rob accepted the position of chief of the Department of Surgery at the University of Rochester, Strong Memorial Hospital and moved to the United States. Here, he continued to develop the technique of vein by-pass grafting. In 1961, after recalling that cloth grafts had been used in the aortas of pigs, he used his shirt to successfully repair an aortic aneurysm in a human. After debriding and resecting the aneurysm, the two open ends of the aorta needed to be rejoined with a graft, but the surgeons found that no graft was available to complete the procedure.
|
|
Confocal microscopy photographs of the descending aortas of two 15-month-old progeria mice, one untreated (left picture) and the other treated with the farnsyltransferase inhibitor drug tipifarnib (right picture). The microphotographs show prevention of the vascular smooth muscle cell loss that is otherwise rampant by this age. Staining was smooth muscle alpha-actin (green), lamins A/C (red) and DAPI (blue). (Original magnification, x 40) Studies have been published indicating that farnesyltransferase inhibitors such as lonafarnib a synthetic tricyclic derivative of carboxamide with antineoplastic properties can reverse instability of nuclear structure due to the genetic mutation of the LMNA gene.
|
|
In research into the association between C. pneumoniae infection and atherosclerosis and coronary artery disease, serological testing, direct pathologic analysis of plaques, and in vitro testing suggest infection with C. pneumoniae is a significant risk factor for development of atherosclerotic plaques and Atherosclerosis. C. pneumoniae infection increases adherence of macrophages to endothelial cells in vitro and aortas ex vivo. However, most current research and data are insufficient and do not define how often C. pneumoniae is found in atherosclerotic or normal vascular tissue. C. pneumoniae has also been found in the cerebrospinal fluid of patients diagnosed with multiple sclerosis.
|
|
Like all cephalopods, the blood of the nautilus contains hemocyanin, which is blue in its oxygenated state. There are two pairs of gills which are the only remnants of the ancestral metamerism to be visible in extant cephalopods. Oxygenated blood arrives at the heart through four ventricles and flows out to the animal's organs through distinct aortas but returns through veins which are too small and varied to be specifically described. The one exception to this is the vena cava, a single large vein running along the underside of the crop into which nearly all other vessels containing deoxygenated blood empty.
|
|
In some groups, these two vessels arise directly from the heart, so that the animal may be said to have two aortas. These two vessels in turn divide into many finer vessels throughout the body, and deliver haemolymph to open arterial sinuses where it bathes and oxygenates the tissues. De-oxygenated haemolymph drains into a large venous sinus within the head and foot, which contains the nephridium, an excretory organ with a function similar to that of the vertebrate kidney. From here it passes into vessels within the gill, or into the capillary network of the pulmonate lung, before returning to the heart.
|
|
Thermographic image of monitor lizards All squamates and turtles have a three-chambered heart consisting of two atria, one variably partitioned ventricle, and two aortas that lead to the systemic circulation. The degree of mixing of oxygenated and deoxygenated blood in the three-chambered heart varies depending on the species and physiological state. Under different conditions, deoxygenated blood can be shunted back to the body or oxygenated blood can be shunted back to the lungs. This variation in blood flow has been hypothesized to allow more effective thermoregulation and longer diving times for aquatic species, but has not been shown to be a fitness advantage.
|
|
It was also found that the ultimate tensile strength, or the strength to withstand rupture, of aneurysmal vessel wall is 50% lower than that of normal aortas. The wall strength of ruptured aneurysmal aortic wall was also found to be 54.2 N/cm2, which is much lower than that of a repaired aorta wall, 82.3 N/cm2. Due to the change in composition of the arterial wall, aneurysms overall have much lower strength to resist rupture. Predicting the risk of rupture is difficult due to the regional anisotropy the hardened blood vessels exhibit, meaning that the stress and strength values vary depending on the region and the direction of the vessel they are measured along.
|
|
In 1963, Collier began working with University of London pharmacology graduate student Priscilla Piper to determine the precise mechanism of aspirin's effects. However, it was difficult to pin down the precise biochemical goings-on in live research animals, and in vitro tests on removed animal tissues did not behave like in vivo tests. After five years of collaboration, Collier arranged for Piper to work with pharmacologist John Vane at the Royal College of Surgeons of England, in order to learn Vane's new bioassay methods, which seemed like a possible solution to the in vitro testing failures. Vane and Piper tested the biochemical cascade associated with anaphylactic shock (in extracts from guinea pig lungs, applied to tissue from rabbit aortas).
|
|
Density-Dependent Colour Scanning Electron Micrograph SEM (DDC-SEM) of cardiovascular calcification, showing in orange calcium phosphate spherical particles (denser material) and, in green, the extracellular matrix (less dense material) Population-based studies show that atherosclerosis, the major precursor of cardiovascular disease, begins in childhood. The Pathobiological Determinants of Atherosclerosis in Youth (PDAY) study demonstrated that intimal lesions appear in all the aortas and more than half of the right coronary arteries of youths aged 7–9 years. This is extremely important considering that 1 in 3 people die from complications attributable to atherosclerosis. In order to stem the tide, education and awareness that cardiovascular disease poses the greatest threat, and measures to prevent or reverse this disease must be taken.
|
|
In a series of studies which were published in the medical journal Pediatrics, researchers from the University of California Department of Pediatrics performed experiments on 113 newborns ranging in age from one hour to three days, in which they studied changes in blood pressure and blood flow. In one of the studies, researchers inserted a catheter through the babies' umbilical arteries and into their aortas, and then submerged their feet in ice water. In another of the studies, they strapped 50 newborn babies to a circumcision board, and turned them upside down so that all of their blood rushed into their heads. The San Antonio Contraceptive Study was a clinical research study published in 1971 about the side effects of oral contraceptives.
|
|
This leads to higher accessibility of pathological gene expression products and activation of pathological genes. Being in this state of diabetic stress leads to long term metabolic memory and altered epigenome with adverse side effects on the cardiovascular system. Oxidized Low-density lipoprotein-induced chemokine expression was associated with H3KAc and phosphorylation, and recruitment of HATs along with NF-κB in endothelial cells, and these were reversed by pre-treatment with statins. Studies show alterations in histone modification patterns, along with changes in expression of the corresponding Histone methyltransferases, in vascular smooth muscle cells and endothelial cells from aortas of adult mice exposed to hypercholesterolaemia. Studies in monocytes, white blood cells that travel along vascular surfaces, showed that H3K9/14Ac and HATs CBP/p300, H3R17me and its methyltransferase CARM1, play key roles in inflammatory gene expression.
|
|
Prior to this, kidneys had been stored at normal body temperatures using blood or diluted blood perfusates, but no successful reimplantations had been made. Fuhrman showed that slices of rat kidney cortex and brain withstood cooling to 0.2 °C for one hour at which temperature their oxygen consumption was minimal. When the slices were rewarmed to 37 °C their oxygen consumption recovered to normal. The beneficial effect of hypothermia on ischaemic intact kidneys was demonstrated by Owens in 1955 when he showed that, if dogs were cooled to 23-26 °C, and their thoracic aortas were occluded for 2 hours, their kidneys showed no apparent damage when the dogs were rewarmed. This protective effect of hypothermia on renal ischaemic damage was confirmed by Bogardus who showed a protective effect from surface cooling of dog kidneys whose renal pedicles were clamped in situ for 2 hours.
|
|