Sylys® Surgical Sealant is intended to be used as an adjunct to standard closure techniques for the reinforcement and protection of anastomotic junctions in colorectal and ileorectal anastomosis procedures.
|
|
Sylys is a resorbable synthetic sealant designed to help reduce anastomotic leakage by providing additional support to the anastomosis during the first few days of healing, when the development of leaks is most likely to occur.
|
|
The Company's second product under development, Sylys® Surgical Sealant, the first synthetic sealant designed specifically to help reduce anastomotic leaks, has received CE Mark approval in Europe as an adjunct to standard closure in ileostomy reversal procedures.
|
|
Anastomotic leakage, which occurs in up to 23 percent of patients undergoing colorectal surgery, is considered to be the most serious surgical complication encountered, frequently resulting in the rapid development of severe peritonitis, septic shock, multiple organ dysfunction, and death.
|
|
"It is tremendous that the FDA has given investigational approval to this novel device that may help reduce the incidence of anastomotic leaks and their devastating impact," said Dr. Deborah Nagle, Chief, Colon and Rectal Surgery, Beth Israel Deaconess Medical Center in Boston, MA. Sylys® Surgical Sealant received Expedited Access Pathway (EAP) status from the FDA in 23628, which recognizes the potential of the product to meet a serious unmet clinical need.
|
|
The peroneal anastomotic is occasionally continued down as a separate branch as far as the heel.
|
|
Studies have been performed comparing various anastomosis approaches taking into account surgical "time and cost, postoperative anastomotic bleeding, leakage, and stricture".
|
|
Surgery- associated ischemia may contribute inflammation at the anal transitional zone. Patients whose cuffitis is refractory to mesalamine and/or corticosteroids should be evaluated for other disease in the cuff area, such as fistula or anastomotic leaks. Cuffitis that is refractory to medication can also be a sign of Crohn's disease of the pouch. Chronic cuffitis can also contribute to the development of anastomotic stricture.
|
|
They are short, fine lines throughout the lungs, with a reticular appearance. They may represent thickening of anastomotic lymphatics or superimposition of many Kerley B lines.
|
|
Leptomeningeal collateral vessels allow limited cerebral blood flow and brain tissue perfusion when the brain receives insufficient blood supply through an artery, via a series of anastomotic connections between cerebral arteries.
|
|
Jean Baptiste Paulin Trolard (27 November 1842 in Sedan, Ardennes – 13 April 1910) was an anatomist known for his work on the anastomotic veins of the cerebral circulation. The "vein of Trolard" (the superior anastomotic vein) was named after him.Google Books Issues in Neurological Surgery and Specialties: 2011 Edition He studied medicine at the Algiers Preparatory College of Medicine, afterwards working as a municipal physician in Saint Eugène, a suburb of Algiers. In 1861, he began work as an anatomy prosector at the college.
|
|
Robbin's publications include more than 300 peer-reviewed journal articles, spanning a variety of research topics including the investigation of stem cells for cardiac regeneration, cardiac transplant allograft vasculopathy, bioengineered blood vessels, and automated vascular anastomotic devices.
|
|
Charles Labbé was a French surgeon, born October 8, 1851, Merlerault, and died October 22, 1889, Paris. He discovered what is now known as the vein of Labbé (inferior anastomotic vein) in his 3rd year of medical school.
|
|
Anastomotic leak is the most frequently encountered complication. Normal results for a ureterostomy include the successful diversion of the urine pathway away from the bladder, and a tension-free, watertight opening to the abdomen that prevents urinary leakage.
|
|
Irreversible urge incontinence due to lesions of the sphincter muscle or a diminished rectal capacity due to resection of too much mucosa, are quite common complications if the procedure is not performed properly. Rectovaginal fistulas and anastomotic diverticula are very rare but possible.
|
|
The superior anastomotic vein, also known as the vein of Trolard, is a superficial cerebral vein grouped with the superior cerebral veins. The vein was eponymously named after the 18th century anatomist Jean Baptiste Paulin Trolard. The vein anastomoses with the middle cerebral vein and the superior sagittal sinus.
|
|
The medial sural cutaneous nerve originates from the tibial nerve of the sciatic, descends between the two heads of the Gastrocnemius, and, about the middle of the back of the leg, pierces the deep fascia, and unites with the anastomotic ramus of the common peroneal to form the sural nerve.
|
|
Lan Xichun (; 1907–1995) was a surgeon of general surgery and cardio-thoracic surgery. He did the first splenic-renal vein anastomotic operation in China. He improved the operation of cholelithiasis and laid the foundation of hepatobiliary surgery in China. He is also one of the pioneers of cardiovascular surgery.
|
|
2004 May;97(5):259-72. Review. . Free Full Text. Collateral or anastomotic blood vessels also exist even when blood supply is adequate to an area, and these blood vessels are often taken advantage of in surgery. Some notable areas where this occurs include the abdomen, rectum, knee, shoulder, and head.
|
|
The ventrum smooth and has a variable pattern consisting of white background and extensive grey to black mottling in an anastomotic pattern. The throat is dark grey and has white spots. The tympanum is relatively large; the supratympanic fold is distinct and reaches arm insertion. The iris is bronze to reddish brown.
|
|
Vessels of the uterus and its appendages, rear view. Schematic diagram of uterine arterial vasculature seen as a cross-section through the myometrium and endometrium The uterus is supplied by arterial blood both from the uterine artery and the ovarian artery. Another anastomotic branch may also supply the uterus from anastomosis of these two arteries.
|
|
Post operatively, both mean resting and squeeze pressures were increased. Constipation is improved in 50% of cases, but often urgency and tenesmus are created. Complications, including infection, urinary retention, bleeding, anastomotic dehiscence (opening of the stitched edges inside), stricture (narrowing of the gut lumen), diarrhea, and fecal impaction occur in 6-32% of cases. Mortality occurs in 0–2.5% cases.
|
|
The superior and inferior pancreaticoduodenal arteries (from the gastroduodenal artery and SMA respectively) form an anastomotic loop between the celiac trunk and the SMA; so there is potential for collateral circulation here. The venous drainage of the duodenum follows the arteries. Ultimately these veins drain into the portal system, either directly or indirectly through the splenic or superior mesenteric vein and then to portal vein .
|
|
It divides into a superficial and a deep branch; the superficial branch supplies the vastus lateralis, and anastomoses with the descending branch of the lateral femoral circumflex and the lateral inferior genicular arteries; the deep branch supplies the lower part of the femur and knee-joint, and forms an anastomotic arch across the front of the bone with the highest genicular and the medial inferior genicular arteries.
|
|
Anastomotic stricture can lead to cholangitis, or inflammation of the bile duct. Narrowing of the bile duct leads to a buildup of pressure, causing the intercellular gaps to widen, exposing the cells to microorganisms found within the bile, resulting in inflammation. Symptoms include jaundice and pain in the upper right quadrant. A CT scan or an endoscopic retrograde cholangiopancreatography (ECRP) could be performed to determine the site of inflammation.
|
|
J Urol, 175(1):140–144, 2006. On the subject of urinary continence, for over 20 years, Dr. Soloway has been a proponent of bladder neck preservation for enhancing urinary continence without compromising cancer control for patients undergoing radical prostatectomy.Shelfo SW, Obek C, Soloway MS. Update on bladder neck preservation during radical retropubic prostatectomy: impact on pathologic outcome, anastomotic strictures, and continence. Urology, 51(1):73-78, 1998.
|
|
Continence Levatorplasty may enhance restoration of continence (2/3 of patients). Complications occur in less than 10% of cases, and include pelvic bleeding, pelvic abscess and anastomotic dehiscence (splitting apart of the stitches inside), bleeding or leak at a dehiscence Mortality is low. Recurrence rates are higher than for abdominal repair, 16-30%, but more recent studies give lower recurrence rates. Additional levatoroplasty can reduce recurrence rates to 7%.
|
|
Optoacoustic imaging in general and MSOT in particular may address a number of challenges for surgical procedures by providing real-time visualization below the tissue surface. In particular, optoacoustic imaging can provide immediate information on the perfusion status of tissues based on analysis of hemoglobin dynamics and oxygenation. This may, for example, detect areas at high risk of anastomotic leakage under ischemic conditions in the colon or esophagus, allowing preventive measures to be taken.
|
|
Glomus tumors were first described by Hoyer in 1877 while the first complete clinical description was given by Masson in 1924. Histologically, glomus tumors are made up of an afferent arteriole, anastomotic vessel, and collecting venule. Glomus tumors are modified smooth muscle cells that control the thermoregulatory function of dermal glomus bodies. As stated above, these lesions should not be confused with paragangliomas, which were formerly also called glomus tumors in now-antiquated clinical usage.
|
|
The lateral sural cutaneous nerve (lateral cutaneous branch of the sural nerve) supplies the skin on the posterior and lateral surfaces of the leg. The lateral sural cutaneous nerve originates from the common peroneal nerve. One branch, the peroneal anastomotic (n. communicans fibularis), arises near the head of the fibula, crosses the lateral head of the gastrocnemius to the middle of the leg, and joins with the medial sural cutaneous nerve to form the sural nerve.
|
|
They pass forward around the optic nerve to the posterior part of the eyeball, pierce the sclera around the entrance of the optic nerve, and supply the choroid (up to the equator of the eye) and ciliary processes. Some branches of the short posterior ciliary arteries also supply the optic disc via an anastomotic ring, the Circle of Zinn-Haller or Circle of Zinn, which is associated with the fibrous extension of the ocular tendons (Annulus of Zinn).
|
|
There are four commonly used types of urethroplasty performed; anastomotic, buccal mucosal onlay graft, scrotal or penile island flap (graft), and Johansen's urethroplasty. With an average operating room time of between three and eight hours, urethroplasty is not considered a minor operation. Patients who undergo a shorter duration procedure may have the convenience of returning home that same day (between 20% and 30% in total of urethroplasty patients). Hospital stays of two or three days duration are the average.
|
|
The thoracoepigastric vein is unique in that it drains to both the Superior Vena Cava (SVC) and to the Inferior Vena Cava (IVC). Hence, it serves as an anastomotic caval-caval link between the two. Furthermore, the thoracoepigastric vein is connected to the portal vein via the paraumbilical vein and thereby serves as a portocaval anastomosis as well. When a patient experiences portal hypertension, there can be congestion (backup) of blood that enters into the caval system via the thoracoepigastric vein.
|
|
The inferior anastomotic vein, also known as the vein of Labbe, is one of several superficial cerebral veins on the human brain. It was named after the 19th century French surgeon Charles Labbé (1851–1889), the nephew of the surgeon and politician Léon Labbé (1832–1916). It crosses and anastomoses at its two ends with the middle cerebral vein and the transverse sinus. The appearance and structural anatomy of the vein itself appears to be highly variable within the human population.
|
|
Survivors enter the liver within 24 hours. From the liver they enter the portal vein to reach different parts of the body. Unlike other species again, the schistosomulae of S. haematobium reach the vesical vessels through anastomotic channels between radicles of the inferior mesenteric vein and pelvic veins. After living inside small venules in the submucosa and wall of the bladder, they migrate to the perivesical venous plexus (a group of veins at the lower portion of the bladder) to attain full maturation.
|
|
CDD is an alternative to choledochojejunostomy, a procedure which involves creating an anastomosis of the CBD to the jejunum. CDD is less technically challenging as the procedure is fast and simple with less anastomotic sites and does not require the creation of a Roux-en-Y anastomosis. It also has better endoscopic access to the biliary tree and more physiologic bile drainage. CDD is used in the treatment of biliary obstruction caused by various factors shown below or when alternative treatment options were not accessible.
|
|
Performing an anastomosis alters the structural composition of bile ducts, which can result in bile stricture obstruction. It leads to slowing of the biliary flow and dilation of the CBD, causing more progressive symptoms of jaundice. An anastomotic stricture is more likely to occur if the choledoctomy incision was less than 2cm in length. The anastomosis could be enlarged by using endoscopic balloon dilation, which consists of inflating a balloon after it is placed in a stenosed region, as a means of widening the stenosed area.
|
|
In human anatomy, Bühler's anastamotic artery (also called the arc of Bühler) is an anastomotic shunt joining the superior mesenteric artery and the celiac trunk in vertical orientation. As the aforesaid arteries arise separately from different levels of the abdominal aorta, the shunt provides limited collateral circulation should a blockage occur in the intervening arterial segment. Bühler's artery is a rare phenomenon present in up to 3% of the population, and is thought to be an unobliterated remnant of the ventral longitudinal anastomosis present during embryological development.
|
|
It is probable that any section of such an alluvial plain would show deposits of a similar character. The floodplain during its formation is marked by meandering or anastomotic streams, oxbow lakes and bayous, marshes or stagnant pools, and is occasionally completely covered with water. When the drainage system has ceased to act or is entirely diverted for any reason, the floodplain may become a level area of great fertility, similar in appearance to the floor of an old lake. The floodplain differs, however, because it is not altogether flat.
|
|
The axillary artery can be safely clamped without endangering the arm, but only in a location proximal to the origin of the subscapular artery (and distal to the thyrocervical trunk of the subclavian artery). The anastomotic network surrounding the scapula provides an alternate path for collateral circulation to the arm from arteries including the dorsal scapular artery and suprascapular artery. The right axillary artery is often used as an arterial cannulation site in cardiac surgery, particularly for repair of aortic dissection and replacement of the ascending aorta and aortic arch.
|
|
The initial research activities of Hans-Joachim Schäfers focused on different clinical problems of heart and lung transplantation. During his fellowship at the University of Toronto (grant of the German Research Council) he investigated the problem of bronchial complications after lung transplantation.Schäfers HJ, Haydock DA, Cooper JD. The prevalence and management of bronchial anastomotic complications in lung transplantation. J Thorac Cardiovasc Surg 1991; 101:1044-52 Both in Hannover and Homburg he initiated important research projects to minimize bronchial complications and to minimize ischemia-reperfusion injury after lung transplantation.
|
|
The incision is inspected and dressed, and the patient is discharged to recovery. (a) some surgeons prefer the use of a suprapubic catheter, as they believe insertion of an in-dwelling urethral catheter may damage the anastomosed area Expected average success rate: The success rate for this procedure is above 95%, anastomotic urethroplasty is considered the "gold standard" of surgical repair options. It is generally used when strictures are less than 2 cm in length, however, some surgeons have had success with defects approaching 3 cm in length.
|
|
Vascular myelopathy (vascular disease of the spinal cord) refers to an abnormality of the spinal cord in regard to its blood supply. The blood supply is complicated and supplied by two major vessel groups: the posterior spinal arteries and the anterior spinal arteries—of which the Artery of Adamkiewicz is the largest. Both the posterior and anterior spinal arteries run the entire length of the spinal cord and receive anastomotic (conjoined) vessels in many places. The anterior spinal artery has a less efficient supply of blood and is therefore more susceptible to vascular disease.
|
|
Léon Labbé Léon Labbé (September 29, 1832 – March 21, 1916) was a French surgeon and politician who was born in the village of Le Merlerault in the department of Orne. He was an uncle to physician Charles Labbé (1851–1889), who first described the inferior anastomotic vein (vein of Labbé). From 1856 to 1860 Labbé was a hospital interne in Paris, and in 1861 earned his medical doctorate. Afterwards, he was a surgeon at several hospitals in Paris, including the Hôpital Beaujon, where he was chief-surgeon for many years.
|
|
Preventive antifungal treatment is supported by studies, but only for specific high-risk groups in intensive care units with conditions that put them at high risk for the disease. For example, one group would be patients recovering from abdominal surgery that may have gastrointestinal perforations or anastomotic leakage. Antifungal prophylaxis can reduce the incidence of fungemia by approximately 50%, but has not been shown to improve survival. A major challenge limiting the number of patients receiving prophylaxis to only those that can potentially benefit, thereby avoiding the creation of selective pressure that can lead to the emergence of resistance.
|
|
Their arrangement is somewhat irregular: one ganglion may give rami to two lumbar nerves, or one lumbar nerve may receive rami from two ganglia. The first and second, and sometimes the third and fourth lumbar nerves are each connected with the lumbar part of the sympathetic trunk by a white ramus communicans. The nerves pass obliquely outward behind the psoas major, or between its fasciculi, distributing filaments to it and the quadratus lumborum. The first three and the greater part of the fourth are connected together in this situation by anastomotic loops, and form the lumbar plexus.
|
|
Septic CST most commonly results from contiguous spread of infection from a nasal furuncle (50%), sphenoidal or ethmoidal sinuses (30%) and dental infections (10%). Less common primary sites of infection include tonsils, soft palate, middle ear, or orbit (orbital cellulitis). The highly anastomotic venous system of the paranasal sinuses allows retrograde spread of infection to the cavernous sinus via the superior and inferior ophthalmic veins. It was previously thought that veins in the area were valveless and that this was the major cause of the retrograde spread, but Studies have since shown that the ophthalmic and facial veins are not valveless.
|
|
Surgical treatment of arterial manifestations of BD bears many pitfalls since the obliterative endarteritis of vasa vasorum causes thickening of the medial layer and splitting of elastin fibers. Therefore, anastomotic pseudoaneurysms are likely to form, as well as pseudoaneurysms at the site of the puncture in case of angiography or endovascular treatment; furthermore, early graft occlusion may occur. For these reasons, invasive treatment should not be performed in the acute and active phases of the disease when inflammation is at its peak. The evaluation of disease's activity is usually based on relapsing symptoms, ESR (erythrocyte sedimentation rate), and serum levels of CRP (C‐reactive protein).
|
|
They run upward at first in front, and subsequently on either side of the intestinal canal. They unite on the ventral aspect of the canal, and beyond this are connected to one another by two anastomotic branches, one on the dorsal, and the other on the ventral aspect of the duodenal portion of the intestine, which is thus encircled by two venous rings; into the middle or dorsal anastomosis the superior mesenteric vein opens. The portions of the veins above the upper ring become interrupted by the developing liver and broken up by it into a plexus of small capillary-like vessels termed sinusoids.
|
|
At this time, using micro surgical technique, the anastomosis is completed and fibrin glue is applied to the anastomotic suture line to help prevent leakage and fistula formation. The silicone guide catheter will then be withdrawn from the penis and (a) replaced by an appropriately sized Foley catheter (and urinary drainage system), and the incision closed (layer by layer). Some surgeons will inject a local anesthetic such as 2% plain lidocaine or 0.5% bupivicaine into the areas to allow the patient an additional period of relief from discomfort. Micro-doppler circulatory measurement of the penile vasculature is performed at way points throughout the procedure, and a final assessment is taken and recorded.
|
|
Having been met with skepticism after his first presentation of appendectomy, he gathered evidence from 250 cases and presented his opinions again as an authority on the subject. A number of procedures and devices were named after Murphy, including Murphy’s button (a mechanical device used for intestinal anastomosis), Murphy’s punch (a punch tenderness at the costo-vertebral angle in cases of perinephric abscess), Murphy's sign (a sign of inflammation of the gallbladder), Murphy’s test (a test for deep-seated tenderness and muscular rigidity in cases of perinephric abscess), Murphy drip for administration of fluids by proctoclysis in patients with peritonitis, and Murphy-Lane bone skid (a common commercial steel instrument used for femoral head procedures). Murphy developed his eponymous anastomotic button for a sutureless anastomosis of the gallbladder to the duodenum (his preferred treatment for acute cholecystitis), but it was equally suitable for intestinal anastomoses. He developed it in the experimental animal laboratory in a barn behind his house and first used it less than a week after developing it on a dog.
|
|