How to use adoptively in a sentence? Find typical usage patterns (collocations)/phrases/context for "adoptively" and check conjugation/comparative form for "adoptively". Mastering all the usages of "adoptively" from sentence examples published by news publications.
By replacing its supplies with a brand like Jarritos, Murphy effectively stymied the demands for Topo with a drink that is still independent, and still adoptively Texan in its own way.
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PTLD may spontaneously regress on reduction or cessation of immunosuppressant medication, and can also be treated with addition of anti-viral therapy. In some cases it will progress to non-Hodgkin's lymphoma and may be fatal. A phase 2 study of adoptively transferred EBV-specific T cells demonstrated high efficacy with minimal toxicity.
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Suggested mechanisms include: # Elimination of T regulatory cells (CD4+CD25+ T cells) in naive and tumor-bearing hosts # Induction of T cell growth factors, such as type I IFNs, and/or # Enhanced grafting of adoptively transferred, tumor-reactive effector T cells by the creation of an immunologic space niche. Thus, cyclophosphamide preconditioning of recipient hosts (for donor T cells) has been used to enhance immunity in naïve hosts, and to enhance adoptive T cell immunotherapy regimens, as well as active vaccination strategies, inducing objective antitumor immunity.
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One such antigen was MAGE-A1. The coexistence of a progressing melanoma with melanoma-specific T cells implicitly does not involve immunoediting, but does not exclude the possibility of TME immune suppression. The discovery of melanoma-specific T cells in patients led to the strategy of adoptively transferring large numbers of in vitro-expanded tumor-infiltrating lymphocytes (TILs) which has proven that the immune system has the potential to control cancer. However, adoptive T cell therapy (ACT) with TILs has not had the dramatic success of ACT with virus-specific CD8+ T cells.
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TILs are expanded over the course of a few weeks with a high dose of IL-2 in 24-well plates. Selected TIL lines that presented best tumor reactivity are then further expanded in a "rapid expansion protocol" (REP), which uses anti-CD3 activation for a typical period of two weeks. The final post-REP TIL is infused back into the patient. The process can also involve a preliminary chemotherapy regimen to deplete endogenous lymphocytes in order to provide the adoptively transferred TILs with enough access to surround the tumor sites.
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Proxicromil acts as an inhibitor of this process, competing with IgE antibodies for binding with the FcεRI receptors, thereby reducing the irritation caused by histamines. The substance was found to reduce allergic reactions and the severity of clinical diseases when administered just before the onset. Furthermore, the antihistamine blocks the elicitation of adoptively transferred EAE, an allergic brain inflammation reaction, and it shows a reducing effect on the severity of skin irritation. The inhibiting effect of Proxicromil on the high-affinity FcεRI disables bonding to the IgE antigen and that way blocks the release of mediators such as histamine that would normally give an allergic response.
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