130 Sentences With "unresponsiveness" | Random Sentence Generator

His unresponsiveness to simple questions has only heightened our concerns.

Some sellers are complaining about Amazon's unresponsiveness to lending inquiries.

This level of unresponsiveness is unheard of within the formal scientific community.

There was also some unresponsiveness on the left-hand side in the video.

"There's a historic unresponsiveness of the M.T.A. bureaucracy to local communities," she said.

Bowden said that members of her BADASS community regularly complain about Instagram's unresponsiveness.

The Amazon lending team's unresponsiveness seems to be a wider, more general problem.

This might manifest as extreme unresponsiveness—staring blankly—or it might manifest as extreme agitation.

Signs of an overdose include blue lips and nails, gurgling or infrequent breathing and unresponsiveness.

The gridlock and the partisan rancor and the unresponsiveness of the government fill countless citizens with despair.

"It's supposed to be the best day of my life, and now we're left with unresponsiveness," Gonzalez said.

Anyone used to video games where your decisions impact the ending might find Mosaic's unresponsiveness a bit frustrating.

Over the next two days, the garrulousness declined into incoherence; then, on Saturday, my father lapsed into unresponsiveness.

He admits that "sounds scandalous," an example of the very kind of unresponsiveness he's critiquing in the book.

However, an autopsy could be helpful to address questions which may arise about the cause of her unresponsiveness and eventual death.

But the dose that produces coma and unresponsiveness is too close to the fatal dose to make it a safe anesthetic.

He argues that it's Trico's unresponsiveness that gives players the impression that he is a separate being with his own agency.

Some patients appear sluggish and have symptoms similar to an opioid overdose, including confusion, respiratory depression, vomiting, seizure, loss of consciousness or unresponsiveness.

The unresponsiveness of the customer service team was so jarring that some customers questioned whether it was a sign the company is struggling.

"Cohen Milstein officially served WikiLeaks via Twitter today given their unresponsiveness," Adrienne Watson, national press secretary of Democratic National Committee, told Gizmodo via email.

Played with an exuberant lack of inhibition by Audrey Tautou, Marie's casual attitude toward consent and partnering goes hand in hand with her unresponsiveness.

Based on his labs, liver failure, age, and unresponsiveness, his doctors said he would never wake up and was likely to die within a few days.

At numerous town hall meetings, soldiers and spouses stood up and expressed frustration over mold, ventilation issues, the contractors' unresponsiveness and significant health concerns arising from mismanagement.

Also, the perceived unresponsiveness of the European Union on matters of immigration and border security create a sense, for many Germans, that they have lost control over their country.

The OECD noted the limited availability of accounting records and ownership information for private foundations in Panama, as well as its unresponsiveness to requests from other countries for tax exchange agreements.

Activists have pushed for the chief to be fired over O'Neill's failure to activate his body camera, and for what they describe as a history of unresponsiveness to the black community.

So while 50 Cent took Farrell's unresponsiveness as a sign of being intoxicated, it turned out to be a pretty normal response from a man who suffers from both social and auditory disabilities.

Sexsomnia is characterized by a sleeper engaging in sexual activities—including masturbation, fondling, and full on intercourse—often with limited awareness, environmental unresponsiveness, and a complete lack of memory of the event ever happening.

If someone notices the signs of an overdose — lips turning blue, restricted pupils, unresponsiveness, a loss of consciousness, among others — it can generally be reversed with drugs like naloxone, which saves thousands of lives a year.

Be attentive to nonverbal cues like unresponsiveness or lack of enthusiasm, and don't assume that your partner will be comfortable enough to speak up all the time—so give them space and empower them to say no.

"Many of those who complain loudest about the company on the Web are particularly bitter about what they consider its longstanding unresponsiveness," the Times wrote of Iomega in 1998, less than a month before Kim B. Edwards stepped down.

The Congressional Black Caucus (CBC) on Wednesday rejected President Trump's invitation for the 49-member group to join him at the White House for a meeting, citing his unresponsiveness on previous attempts at policy engagement as proof that Trump isn't interested in working with the members beyond a photo op.

This unresponsiveness to today's students -- who are much more likely to be students of color, English language learners, women and openly LGBTQ -- prevents us from reaching our full potential by making it more likely some students will drop out of school, fall victim to fraudulent institutions or cruel institutional practices, or simply be overwhelmed with debt.

The very "norms" by which Washington operates, covering everything from America's objectives in foreign policy to the imperative of multilateral trade deals to the legal ways in which career politicians and their families can make millions off their connections, are seen by Mr. Trump and his voters as the source of the country's ills — from endless wars to declining manufacturing employment to the unresponsiveness of politicians in both parties to the country's pain.

With this apologia for Elodie's unresponsiveness, conscientiously recorded later by Andrew Lackaday, we will now proceed.

Seizures may very rarely occur. Near-death stages include the animal showing signs of drowsiness and unresponsiveness.

Marked recent weight loss is a major clinical manifestation, and unresponsiveness of the ascites to diuretics is an additional diagnostic clue.

Plant Primary Perception: Electrophysiological Unresponsiveness to Brine Shrimp Killing. Science 189: 478-480. Other controlled experiments that attempted to replicate Backster's findings have also produced negative results.

These are predominantly seen by unresponsiveness in conversations, lesser emotional sharing, inability to initiate conversations, inability to interpret body language, avoidance of eye-contact and difficulty maintaining relationships.

The most common symptom of abdominal epilepsy is abdominal pain followed by uncontrollable vomiting, usually preceded by lethargy. Symptoms also include generalized tonic-clonic seizures followed by sleep, confusion, and unresponsiveness.

Lateral recumbency, muscle flaccidity, unresponsiveness to stimuli, and loss of consciousness progressing to coma. Heart rate can approach 120 bpm, with peripheral pulses becoming undetectable. If untreated, progression will continue to death.

However, research has provided evidence that monkeys, dogs, cats and birds can show signs of emotional pain and display behaviours associated with depression during painful experience, i.e. lack of motivation, lethargy, anorexia, unresponsiveness to other animals.

Absence status epilepticus is marked by a generalized seizure affecting the whole brain. An EEG is needed to differentiate between the two conditions. This results in episodes characterized by a long-lasting stupor, staring, and unresponsiveness.

However, research has provided evidence that monkeys, dogs, cats and birds can show signs of emotional pain and display behaviours associated with depression during painful experience, i.e. lack of motivation, lethargy, anorexia, unresponsiveness to other animals.

Using ACDU, a patient is assessed for alertness, confusion, drowsiness, and unresponsiveness. The Grady Coma Scale classes people on a scale of I to V along a scale of confusion, stupor, deep stupor, abnormal posturing, and coma.

The symptoms of an opiate toxidrome include the classic triad of coma, pinpoint pupils, and respiratory depression as well as altered mental states, shock, pulmonary edema and unresponsiveness. Complications include bradycardia, hypotension, and hypothermia. Substances that may cause this toxidrome are opioids.

Complex partial status epilepticus (CPSE) is one of the non-convulsive forms of status epilepticus, a rare form of epilepsy defined by its recurrent nature. CPSE is characterized by seizures involving long-lasting stupor, staring and unresponsiveness. Sometimes this is accompanied by motor automatisms, such as eye twitching.

Tiagabine overdose can produce neurological symptoms such as lethargy, single or multiple seizures, status epilepticus, coma, confusion, agitation, tremors, dizziness, dystonias/abnormal posturing, and hallucinations, as well as respiratory depression, tachycardia, hypertension, and hypotension. Overdose may be fatal especially if the victim presents with severe respiratory depression and/or unresponsiveness.

Glucosinolates are feeding deterrents and are toxic to non-adapted herbivores. With higher glucosinolate concentrations, there is reduced feeding by S. eridania on B. juncea, a host plant. There is relative unresponsiveness of S. eridania to variation in myrosinase activity. This suggests that glucosinolates may have originated as defenses against generalist herbivores.

Unrequited love made him very short-tempered, impulsive and obsessive about Narin. Due to the unresponsiveness of his wife, Mustafa subjected Narin to beating. Both Mustafa and Narin suffered emotional and physical scars of this unconsummated marriage. But while Narin's physical torture was witnessed by the town, Mustafa's pain was never understood.

This cooperation between RCCs and mainstream organizations represents a shift in RCC strategies; they have moved from being outside critics of mainstream organizations to indoctrinating allies with them. A close relationship between RCCs and mainstream organizations leads to various opportunities and constraints that affect the quality of a community's responsiveness to rape. Among the opportunities are access to rape survivors that first approach mainstream organizations, the ability to teach mainstream organizations about rape, and the ability to develop responsive interorganizational protocols. Constraints include the inability to publicly criticize the unresponsiveness of mainstream organizations, an increased likelihood of cooptation to mainstream views, a shift of the focus toward survivors and away from social and political change, and a greater tolerance for mainstream unresponsiveness.

Indira Nath (born 14 January 1938) is an Indian immunologist. Her major contribution in medical science deals with mechanisms underlying immune unresponsiveness in man, reactions and nerve damage in leprosy and a search for markers for viability of the Leprosy bacillus. Prof. Nath's fields of specialisations are Immunology, Pathology, Medical biotechnology and communicable diseases.

In attacks that begin when an individual is fully alert, olfactory hallucinations or a "strange taste" or nausea have been reported. Somewhat less than half the cases include olfactory or gustatory hallucinations, and slightly more than a third involve motor automatisms. A quarter of attacks involve a brief period of unresponsiveness. Frequently, however, there is no warning.

Pilot unresponsiveness can be attributed to many factors including: distraction, task saturation, incapacitation, and unconsciousness. The Auto- GCAS system successfully reduced the leading cause of F-16 pilot fatalities. The Automatic Ground Collision Avoidance System was first developed at the Lockheed Martin Skunk Works and NASA. NASA publications site working on Auto- GCAS starting in 1997.

The typical patient with ketotic hypoglycemia is a young child between the ages of 10 months and 4 years. Episodes nearly always occur in the morning after an overnight fast, often one that is longer than usual. Symptoms include those of neuroglycopenia, ketosis, or both. The neuroglycopenic symptoms usually include lethargy and malaise, but may include unresponsiveness or seizures.

Delays were however exacerbated due to Solis' perceived unresponsiveness to questions. On February 11, the United States Senate Committee on Health, Education, Labor, and Pensions voted by voice vote to endorse Hilda Solis as the Labor Secretary, with the only dissenting members of the 22-person committee Republicans Tom Coburn and Pat Roberts. Solis was later confirmed on February 24.

Prey received "generally favorable" reviews from critics, according to review aggregator Metacritic. Critics praised the fully realized atmosphere of Talos I, with some labeling it a "luxurious sci-fi playground". On the other hand, combat proved divisive. GameSpot's Tamoor Hussain found fight sequences "rewarding", while IGN's Dan Stapleton considered combat Preys "biggest weakness" partly due to periods of AI unresponsiveness.

Clownface began as a stray piece of Clayface's body that became unattached and gained enough sentience to morph itself into a mute old man. This man was found and taken to Arkham Manor because of his unresponsiveness. Arkham Manor #2 (vol. 1), November 26, 2014 Later, the Joker, infected this portion of Clayface with Joker Venom, morphing it into an entirely separate killing machine he called Clownface.

The colonists were disenchanted with Kieft, his ignorance of indigenous peoples, and the unresponsiveness of the WIC to their rights and requests, and they submitted the Remonstrance of New Netherland to the States General. This document was written by Leiden-educated New Netherland lawyer Adriaen van der Donck, condemning the WIC for mismanagement and demanding full rights as citizens of the province of the Netherlands.

This same positive and negative selection mechanism, but in peripheral tissues, is known as clonal anergy. The mechanism of clonal anergy is important to maintain tolerance to many autologous antigens. Active suppression is the other known mechanism of T cell tolerance. Active suppression involves the injection of large amounts of foreign antigen in the absence of an adjuvant which leads to a state of unresponsiveness.

Apoptosis plays an active role in regulating the immune system. When it is functional, it can cause immune unresponsiveness to self-antigens via both central and peripheral tolerance. In the case of defective apoptosis, it may contribute to etiological aspects of autoimmune diseases. The autoimmune disease type 1 diabetes can be caused by defective apoptosis, which leads to aberrant T cell AICD and defective peripheral tolerance.

The commune is a model of government that is generally advocated by communists, revolutionary socialists, and anarchists. The model is often characterized as being a local and transparent organization composed of delegates bound by mandates. These delegates would be recallable at any time from their positions. Proponents view the right of recall as a particularly important safeguard against corruption and unresponsiveness among the representatives.

Instead, after delivering the offer, Brunson withdrew from the engagement. When the WPT publicly disclosed Brunson and his law firm's unresponsiveness, its stock price sharply declined, costing investors tens of millions of dollars in lost market value. The offer eventually expired by its terms. The SEC formally investigated whether Brunson's offer and its publication violated federal securities laws, including the anti-fraud provisions of the Securities Exchange Act of 1934.

Full recovery is seen in 50 to 70% of cases, ranging to 70 to 90% recovery with some minor residual disability (typically assessed using measures such as mRS or EDSS), average time to recover is one to six months. The mortality rate may be as high as 5%-10%."Menge et al. 2007" Poorer outcomes are associated with unresponsiveness to steroid therapy, unusually severe neurological symptoms, or sudden onset.

Most of the pupils in his class are unmotivated to learn, and are only semi-literate and semi- articulate. He persists despite their unresponsiveness to his approach. Students attempt to discourage and demoralise him by disruptive noises, constant use of the adjective "bleeding" in the classroom and, finally, the burning of a used sanitary towel in the fireplace. This last causes Braithwaite to lose his temper and reprimand all the girls.

In overdose, phenibut can cause severe drowsiness, nausea, vomiting, eosinophilia, lowered blood pressure, renal impairment, and, above 7 grams, fatty liver degeneration. There are no specific antidotes for phenibut overdose. Lethargy, somnolence, agitation, delirium, tonic–clonic seizures, reduced consciousness or unconsciousness, and unresponsiveness have been reported in recreational users who have overdosed. Management of phenibut overdose includes activated charcoal, gastric lavage, induction of vomiting, and symptom-based treatment.

When exposed to polar narcotics, rainbow trout first exhibited increased muscular activity followed by incoordination and unresponsiveness to external stimuli. In general, narcosis II is characterized by greater toxicity than narcosis I. Thus, Baseline-narcosis models should be used for predicting the toxicity of nonpolar narcotics. In addition, narcosis I is the generalized depression of biological activity. In contrast, narcosis II symptoms include stimulation of respiratory-cardiovascular responses followed by generalized depression of activity.

However, because it is rare in the general population, it is sometimes overlooked when a patient does not wake-up after surgery. If this happens, there are two major complications that can arise. First, the patient may lie awake and paralyzed, while medical providers try to determine the cause of the patient’s unresponsiveness. Second, the breathing tube may be removed before the patient is strong enough to breathe properly, potentially causing respiratory arrest.

High frequency stimulation (HFS) in cat claustrum(s) has the capability to induce autonomic changes and induce “inactivation syndrome”. This syndrome is described as a decrease in awareness, indicating the relationship between the claustrum and consciousness. In humans this same effect can be observed. Stimulation of the left claustrum in humans has produced 'a complete arrest of volitional behavior, unresponsiveness, and amnesia without negative motor symptoms or mere aphasia' suggesting the involvement in consciousness.

The Indiegogo campaign raised nearly $830,000 of its original $150,000 goal. Several alternate character and announcer voice packs were also funded. All downloadable characters and voice packs were free to download on all platforms within the first three months of their release. On November 7, 2013, Lab Zero Games announced that Autumn Games had severed ties with Konami, citing Konami's unresponsiveness as a major hurdle to the release of further console patches.

In Cape Town, South Africa, seven children developed vomiting, diarrhea, and dehydration, and died of kidney failure after administration of over-the-counter sedatives. Soon, patients started to present anuria, acidic breathing, hepatomegaly, and unresponsiveness. Patients were treated with fluid hydration and correction of acidosis, but some were not able to survive. Postmortem examination revealed damage in the kidneys and liver, and laboratory testing found DEG instead of propylene glycol in the sedatives.

Many guerrilla tactics react to the delays and inefficiencies in attempting to follow proper or legal channels. For example, when local residents appeal to a public works department for an additional crosswalk near a school, impatience will inevitably set in after a time of unresponsiveness. Sometimes an act such as painting an unsanctioned crosswalk is the only response that will move some jurisdictions to action. Many activists are frustrated with their local street system.

There is more Treg activity compared to Th17 activity, and the immune response to the virus is less aggressive and effective. Revitalizing Th17 cells has been shown to decrease symptoms of chronic infection, including decreased inflammation, and results in improved responses to highly active anti-retroviral treatment (HAART). This is an important finding—microbial translocation general results in unresponsiveness to HAART. Patients continue to exhibit symptoms and do not show as reduced a viral load as expected.

The group claimed that only 10 interviewees did not support PRH tenants keeping dogs, meaning that over 99% of the interviewees support dog keeping in PRH estates. The group found the root cause lies in the unresponsiveness of government to recommendations given by the public. They suggested different government departments, such as the Housing Department, Agriculture, Fisheries and Conservation Department and Leisure and Cultural Services Department, to cooperate instead of working on their own when implementing animal friendly policies.

These decks were fairly popular in the mid 2000s but have largely fallen out of favor due to their unresponsiveness. Flush mounts seek to lower the ride height by mounting the trucks in a recessed area on the board. This minimally lowers ride height but increases the chance for wheel bite (which is where the wheels rub against the board in a turn, usually resulting in a crash). The vast majority of downhill longboards are built from wood.

Discretion and personal judgment play a large part in such systems, to determine whether corrective action should be taken. Perhaps the most difficult problem in human systems is the unresponsiveness of individuals to indicated correction. This may take the form of opposition and subversion to control, or it may be related to the lack of defined responsibility or authority to take action. Leadership and positive motivation then become vital ingredients in achieving the proper response to input requirements.

If the tremor of the other hand entrains to the same rhythm, stops, or if the patient has trouble copying a simple movement this may indicate a functional tremor. Functional dystonia usually presents with an inverted ankle posture or clenched fist. Positive features of dissociative or non-epileptic attacks include prolonged motionless unresponsiveness, long duration episodes (>2minutes) and symptoms of dissociation prior to the attack. These signs can be usefully discussed with patients when the diagnosis is being made.

In other amphibians, the metamorphosis is regulated by the hormone thyroxine, secreted by the thyroid gland. The thyroid is normally developed and functioning in the olm, so the lack of metamorphosis is due to the unresponsiveness of key tissues to thyroxine. Disproportionately elongated head with gills The olm swims by eel-like twisting of its body, assisted only slightly by its poorly developed legs. It is a predatory animal, feeding on small crustaceans (for example, Troglocaris shrimp), snails and occasionally insects.

Muselmann (pl. Muselmänner, the German version of Musulman, meaning Muslim) was a slang term used among captives of World War II Nazi concentration camps to refer to those suffering from a combination of starvation (known also as "hunger disease") and exhaustion and who were resigned to their impending death. The Muselmann prisoners exhibited severe emaciation and physical weakness, an apathetic listlessness regarding their own fate, and unresponsiveness to their surroundings owing to their barbaric treatment by prisoner functionaries.Muselmann definition Johannes Kepler University of Linz, official website.

Especially chronic comatose and vegetative patients, when recovery is highly unlikely and treatment in the ICU is considered futile by clinicians. In addition to the aforementioned problems, the question rises why medical resources were being used not for the broader public good but for patients who seemed to have only little to gain from them. Still research is everything but sure about the irreversibility of these conditions. Some studies demonstrated that some patients suffering from disorders of consciousness may be aware despite clinical unresponsiveness.

Maria Korp (born Maria Matilde; 14 January 1955 – 5 August 2005) was a Portuguese-born Australian woman reported missing for four days and later found, barely alive, in the boot of her car on 13 February 2005. She spent a short time in a coma before emerging into a state of post-coma unresponsiveness. She became the centre of a controversy in Australia during 2005. Depending upon their viewpoint, people have characterised the controversy as being about euthanasia or about human rights and protecting people with disabilities.

Hangman scares Beth with a popped light bulb to stop her from investigating the attic after she hears another strange sound. Beth suggests purchasing a gun to feel safe and Aaron agrees. Marley notices Hangman recording her while she makes out with her boyfriend Miles at a Lovers’ Lane. Miles confronts Hangman, but the teenage couple drives away when they become creeped out by his unresponsiveness. Aaron and Beth host dinner for Beth’s friend Melissa and Melissa’s husband. While the quartet dines, Hangman goes through Melissa’s purse.

As with other GABAergic drugs, combination with other GABAergic drugs, including alcohol, as well as with sedatives in general, possess a significant risk to the user in the form of overdose. Overdose symptoms are similar to those of other GABAergics including excessive sedation and unresponsiveness to stimuli, severe ataxia, amnesia, confusion, agitation, intoxication and inappropriate (potentially violent) behavior. Severe overdoses may present with respiratory depression (and subsequent pulmonary aspiration), coma, and death. Carisoprodol is not detected on all toxicology tests which may delay diagnosis of overdose.

Subsequently, a colonist was murdered in an act of revenge for some killings that had taken place years earlier and the Indians refused to turn over the perpetrator. Kieft suggested that they be taught a lesson by ransacking their villages. In an attempt to gain public support, he created the citizens commission the Council of Twelve Men. The Council did not rubber- stamp his ideas, as he had expected them to, but took the opportunity to mention grievances that they had with the company's mismanagement and its unresponsiveness to their suggestions.

Viewership in 2004 increased but remained a distant fifth place behind other free-to-air television services in Slovenia. On 1 November 2004, the channel was shutdown and Prva TV began to use its frequencies. Later, on 1 July 2006, the channel was bought by Swedish media company Modern Times Group, and from 1 October 2006, the channel were relaunched, this time in reference to the Modern Times Group corporate brand TV3 Viasat. On 29 February 2012, it ceased broadcasting due to uncompetitive environment and unresponsiveness of Slovenian authorities.

Sodium stibogluconate is available in the United Kingdom as Pentostam, where it is manufactured by GlaxoSmithKline. It is available in the United States on a named-patient basis from the Centers for Disease Control and Prevention (CDC). As dosage regimens for treating leishmaniasis have evolved, the daily dose of antimony and the duration of therapy have been progressively increased to combat unresponsiveness to therapy. In the 1980s, the use of 20 mg/kg/day (instead of 10 mg/kg/day) of antimony was recommended, but only to a maximum daily dose of 850 mg.

Jacobs extended his analysis of elite efforts at manipulation with James Druckman in the 2015 book Who Governs? Presidents, Public Opinion, and Manipulation. Citing polls and other evidence from presidential archives, they reported that presidents starting with Lyndon Johnson used their private research on public opinion to design arguments and personal images to build personal popularity and win elections in order to defy the policy preferences of most Americans. Jacobs’s investigation of the sources of U.S. international economic and foreign policy confirmed the pattern of weak government unresponsiveness to the policy preferences of most Americans.

Symptoms of meprobamate overdose include drowsiness, headache, sluggishness, unresponsiveness, or coma; loss of muscle control; severe impairment or cessation of breathing; or shock.livertox.nlm.nih.gov -Meprobamate , overview Death has been reported with ingestion of as little as 12 g of meprobamate and survival with as much as 40 g. In an overdose, meprobamate tablets may form a gastric bezoar, requiring physical removal of the undissolved mass of tablets through an endoscope; therefore, administration of activated charcoal should be considered even after 4 or more hours or if levels are rising.

However, the acronym "PVS" is intended to define a "persistent vegetative state", without necessarily the connotations of permanence, and is used as such throughout this article. Bryan Jennett, who originally coined the term "persistent vegetative state", has now recommended using the UK division between continuous and permanent in his book The Vegetative State, arguing that "the 'persistent' component of this term ... may seem to suggest irreversibility". The Australian National Health and Medical Research Council has suggested "post coma unresponsiveness" as an alternative term for "vegetative state" in general.

Mahmoud was the first reporter killed during the uprising in Egypt between protestors and Mubarak forces. The killing of a journalist and then the unresponsiveness of the ambulance has shaken Egypt's journalism community and furthered protests against the current regime. Mahmoud's widow and fellow journalist, Inas Abdel-Alim, is demanding a full on investigation from the government and a trial for the murder of her husband. Lucas Dolega, who was the first journalist killed in the Arab Spring uprising during the Tunisian uprising, was also killed while covering a protest.

Attention itself has been considered as top-down processing or bottom-up processing; both fit contextually with what is observed in the claustrum structurally and functionally, supporting the notion that interactions occur with high-order sensory areas involved in encoding objects and features. Input from the prefrontal cortex, for example, will define attention based upon higher- cognitive task driven behaviour. Moreover, induction of electrical stimulation to the claustrum has been shown to cause inhibition reading, a blank stare, and unresponsiveness. It has been reported that the claustrum has a basal frequency firing that is modulated to increase or decrease with directed attention.

Patients with CTD are unresponsive to oral creatine monohydrate supplements because regardless of the amount of creatine they ingest, the creatine transporter is still defective, and therefore creatine is incapable of being transported across the BBB. Given the major role that the BBB has in the transport of creatine to the brain and unresponsiveness of oral creatine monohydrate supplements in CTD patients, future research will focus on working with the BBB to deliver creatine supplements. However, given the limited number of patients that have been identified with CTD, future treatment strategies must be more effective and efficient when recognizing individuals with CTD.

Adamson received her B.A. in Psychology, with minors in Biology and Sociology, from Swarthmore College in 1970. She then attended the University of California, Berkeley where she completed her M.A. in Psychology in 1972 and her Ph.D. in Psychology in 1977. Early in her career as a Research Scientist at Children's Medical Center, Boston, she gained experience in infancy research working with Edward Tronick, Heidelise Als, and T. Berry Brazelton. This research team developed the still face paradigm, a widely used assessment of young infants' reactions to the sudden unresponsiveness of an adult during face-to-face interaction.

Over the past 100 years, the study and administration of anesthesia has become more complex. Historically anesthesia providers were almost solely utilized during surgery to administer general anesthesia in which a person is placed in a pharmacologic coma. This is performed to permit surgery without the individual responding to pain (analgesia) during surgery or remembering (amnesia) the surgery. In the nineteenth century the beginnings of general anesthesia started with the introduction of ether in Boston and chloroform in the United Kingdom to bring about a state of unawareness and unresponsiveness to the pain of surgical insult.

Medawar was the youngest child of a Lebanese father and a British mother, and was both a Brazilian and British citizen by birth. He studied at Marlborough College and Magdalen College, Oxford and was professor of zoology at the University of Birmingham and University College London. Until he was partially disabled by a cerebral infarction, he was Director of the National Institute for Medical Research at Mill Hill. With his doctoral student Leslie Brent and postdoctoral fellow Rupert E. Billingham, he demonstrated the principle of acquired immunological tolerance (the phenomenon of unresponsiveness of the immune system to certain molecules), which was theoretically predicted by Sir Frank Macfarlane Burnet.

Brad is sent home to his family, where his condition causes some tension, something not helped by his sister Ashley's insensitive boyfriend, Gavyn. As the hours' pass, Brad's body and mind deteriorate. He has periods of unresponsiveness, suffers from seizures, a wound on his right foot worsens, he becomes gaunter, his eyes and tongue swell, his fingernails and teeth yellow, and he begins expelling a black fluid from his ears, mouth, and anus. In the morning after his return, Brad is found by his mother, Karmen, ingesting a large amount of salt in the kitchen, having apparently entered the room under his own power.

Ashamed by what he read about the unresponsiveness of her neighbors, Kovacs became disillusioned with the underlying apathy that he saw as inherent in most people. Inspired by Genovese's fate, Kovacs returned home, made "a face [he] could bear to look at in the mirror" from the dress's fabric, and began fighting crime as the vigilante Rorschach. Initially, Kovacs left criminals alive, but bloodied, for the police to arrest, leaving a calling card in the form of a Rorschach test at every crime scene. In the mid 1960s, he teamed up with Nite Owl II, a partnership which proved highly successful at battling organized crime.

Presently, there is hot debate over the protocol for diagnosing someone as brain dead due to widespread disinformation and misinformation on the internet. The American Academy of Neurology created a prerequisite and neurological clinical assessment to be used as guidelines for determining brain death published in 2010. To be considered for brain death the body must have a determinant cause of coma, have normal systolic blood pressure, and pass two neurological tests. These neurological assessments commonly consist of an apnea test, reflex tests where the body is manipulated or exposed to a stimulus and does not react, or be in a coma where there is complete unresponsiveness.

Nonetheless, on June 15, 2007, Karasai district officials again brought a demolition crew to the commune and destroyed an additional 12 homes, destroying many possessions and leaving the residents homeless. At the end of the reporting period, the situation remained tense and unresolved, and the Hare Krishnas continued to allege judicial violations by local officials and unresponsiveness on the part of the government. Although many observers believed the Karasai district government's actions were motivated primarily by a financial interest in the land, the Hare Krishnas claimed the local government targeted them because they are a nontraditional religious community. Local officials criticized the Hare Krishnas as an illegitimate and threatening religious group.

Androgen insensitivity syndrome (AIS) is an intersex condition occurring in 1:20,000 individuals to 1:64,000, resulting in the partial or complete inability of the cell to respond to androgens. The unresponsiveness of the cell to the presence of androgenic hormones can impair or prevent the masculinization of male genitalia in the developing fetus, as well as impairing or preventing the development of male secondary sexual characteristics at puberty, but does not significantly impair female genital or sexual development. As such, the insensitivity to androgens is clinically significant only when it occurs in genetic males (i.e. individuals with a Y-chromosome, or more specifically, an SRY gene).

Croke, in an era when intimidation of counsel was frequent, was noted for his 'discretion' in court. In 1602, Croke was involved in a divisive witchcraft case of the era, in which he performed a series of a tests on the 14-year-old accuser, Mary Glover, and the defendant, Elizabeth Jackson; he came to the conclusion that Glover was bewitched after witnessing her reaction to a disguised Jackson, and her unresponsiveness to heat, which left visible burns. The evidence obtained was used in trial, though Sir Edmund Anderson was principal judge; Jackson was convicted to one year's imprisonment, but was released early. He was elected Speaker unanimously in 1601.

In August 2008, the CFTC set up a special task force to deal with growing foreign exchange fraud. In January 2010, the CFTC proposed new rules limiting leverage to 10 to 1, based on "a number of improper practices" in the retail foreign exchange market, "among them solicitation fraud, a lack of transparency in the pricing and execution of transactions, unresponsiveness to customer complaints, and the targeting of unsophisticated, elderly, low net worth and other vulnerable individuals".The Federal Register Section E. The Commission's Proposed Rules In 2012, Christopher Ehrman, an SEC veteran, was selected to run the new SEC Office of the Whistleblower.

To Prasad this news precluded Indian occupation of the ridge, since the Chinese could now move onto it at short notice." Scholars find the inefficiencies of the Army command responsible for the Indian inaction, but at the same time the lack of clarity on where the border lay and indecision on how far to go in confronting the Chinese seem to have played a role. In contrast, the Chinese moved decisively.: "Therefore, the unresponsiveness of higher echelons to the questions raised by Prasad..., the need for personal intervention by Palit, the referral to the MEA..., and the fact that Army Headquarters did not respond to Gopal's information with a clear decision...—all served to prevent a preemptive Indian move.

Complete androgen insensitivity syndrome (CAIS) is a condition that results in the complete inability of the cell to respond to androgens. As such, the insensitivity to androgens is only clinically significant when it occurs in individuals with a Y chromosome or, more specifically, an SRY gene. The unresponsiveness of the cell to the presence of androgenic hormones prevents the masculinization of male genitalia in the developing fetus, as well as the development of male secondary sexual characteristics at puberty, but does allow, without significant impairment, female genital and sexual development in those with the condition. All human fetuses begin fetal development looking similar, with both the Müllerian duct system (female) and the Wolffian duct system (male) developing.

Those with social- emotional agnosia have difficulty discerning the emotional meaning and significance behind objects, which causes a loss of fondness and familiarity. Bilateral amygdala damage has also been associated with social unresponsiveness, leading to an avoidance of social interactions and a preference for isolation from their own species. Evidence suggests that damage to the amygdala and the limbic system (specifically the amygdala-hypothalamus pathway) results in the loss of the core ability to recognize and interpret the mental states of others, a vital ability in social interactions. The amygdala evokes highly personal emotional memories and the loss of this function causes hypo-emotionality, a general lack of emotion when presented with different stimuli.

Two days prior to Childs arrest Marinaccio received an alarming email stating Childs grievances towards DTIC management and their lack of security awareness since they were previously hacked; which he claims the City officials wrote off. Marinaccio noted the unresponsiveness and email in his final report. He was found guilty of one count of felony network tampering on April 27, 2010 by a jury. On August 6, 2010, Childs was sentenced to four years in the California State Prison by Judge Teri Jackson. Childs had already served 755 days in prison as of his sentencing, which was applied to his sentence, leaving him eligible for parole after 4–6 months of incarceration.

Metabolic studies are useful, but they are not able identify neural activity within a specific region to specific cognitive processes. Functionality can only be identified at the most general level: Metabolism in cortical and subcortical regions that may contribute to cognitive processes. At present, there is no established relation between cerebral metabolic rates of glucose or oxygen as measured by PET and patient outcome. The decrease of cerebral metabolism occurs also when patients are treated with anesthetics to the point of unresponsiveness. Lowest value (28% of normal range) have been reported during propofol anesthesia. Also deep sleep represents a phase of decreased metabolism (down to 40% of the normal range)Maquet P, Degueldre C, Delfiore G, et al.

The term "infectious tolerance" was originally used by Gershon and Kondo in 1970 for suppression of naive lymphocyte populations by cells with regulatory function and for the ability to transfer a state of unresponsiveness from one animal to another. Gershon and Kondo discovered that T cells can not only amplify but also diminish immune responses. The T cell population causing this down-regulation was called suppressor T cells and was intensively studied for the following years (nowadays they are called regulatory T cells and are again a very attractive for research). These and other research in the 1970s showed greater complexity of immune regulation, unfortunately these experiments were largely disregarded, as methodological difficulties prevented clear evidence.

Teplizumab (also known as PRV-031; formerly also known as MGA031 and hOKT3γ1(Ala-Ala)) is a humanized anti-CD3 monoclonal antibody that is being evaluated for treatment and prevention of type 1 diabetes mellitus (T1DM) by the biopharmaceutical company Provention Bio. Teplizumab has also been evaluated for treatment of renal allograft rejection, for induction therapy in islet transplant recipients, and for psoriatic arthritis. The Fc region of this antibody has been engineered to have Fc receptor non-binding (FNB) properties. The mechanisms of action of teplizumab appear to involve weak agonistic activity on signaling via the T cell receptor-CD3 complex associated with the development of anergy, unresponsiveness, and/or apoptosis, particularly of unwanted activated Teff cells.

Although diagnosis of coma is simple, investigating the underlying cause of onset can be rather challenging. As such, after gaining stabilization of the patient's airways, breathing and circulation (the basic ABCs) various diagnostic tests, such as physical examinations and imaging tools (CT scan, MRI, etc.) are employed to access the underlying cause of the coma. When an unconscious person enters a hospital, the hospital utilizes a series of diagnostic steps to identify the cause of unconsciousness. According to Young, the following steps should be taken when dealing with a patient possibly in a coma: # Perform a general examination and medical history check # Make sure the patient is in an actual comatose state and is not in locked-in state or experiencing psychogenic unresponsiveness.

The disease most commonly associated with mutations in SCNN1B is the multi-system form of type I pseudohypoaldosteronism (PHA1B) that was first characterized by A. Hanukoglu as an autosomal recessive disease. This is a syndrome of unresponsiveness to aldosterone in patients that have high serum levels of aldosterone but suffer from symptoms of aldosterone deficiency with a high risk of mortality due to severe salt loss. Initially, this disease was thought to be a result of a mutation in the mineralocorticoid receptor (NR3C2) that binds aldosterone. But homozygosity mapping in 11 affected families revealed that the disease is associated with two loci on chromosome 12p13.1-pter and chromosome 16p12.2-13 that include the genes for SCNN1A and SCNN1B and SCNN1G respectively.

Sometimes a distinction is made between "physical pain" and "emotional" or "psychological pain". Emotional pain is the pain experienced in the absence of physical trauma, for example, the pain experienced by humans after the loss of a loved one, or the break-up of a relationship. It has been argued that only primates and humans can feel "emotional pain", because they are the only animals that have a neocortexa part of the brain's cortex considered to be the "thinking area". However, research has provided evidence that monkeys, dogs, cats and birds can show signs of emotional pain and display behaviours associated with depression during or after a painful experience, specifically, a lack of motivation, lethargy, anorexia, and unresponsiveness to other animals.

The disease most commonly associated with mutations in SCNN1A is the multi-system form of type I pseudohypoaldosteronism (PHA1B) that was first characterized by A. Hanukoglu as an autosomal recessive disease. This is a syndrome of unresponsiveness to aldosterone in patients that have high serum levels of aldosterone but suffer from symptoms of aldosterone deficiency with a high risk of mortality due to severe salt loss. Initially, this disease was thought to be a result of a mutation in the mineralocorticoid receptor (NR3C2) that binds aldosterone. But homozygosity mapping in 11 affected families revealed that the disease is associated with two loci on chromosome 12p13.1-pter and chromosome 16p12.2-13 that include the genes for SCNN1A and SCNN1B and SCNN1G respectively.

The disease most commonly associated with mutations in SCNN1B is the multi-system form of type I pseudohypoaldosteronism (PHA1B) that was first characterized by A. Hanukoglu as an autosomal recessive disease. This is a syndrome of unresponsiveness to aldosterone in patients that have high serum levels of aldosterone but suffer from symptoms of aldosterone deficiency with a high risk of mortality due to severe salt loss. Initially, this disease was thought to be a result of a mutation in the mineralocorticoid receptor (NR3C2) that binds aldosterone. But homozygosity mapping in 11 affected families revealed that the disease is associated with two loci on chromosome 12p13.1-pter and chromosome 16p12.2-13 that include the genes for SCNN1A and SCNN1B and SCNN1G respectively.

At this point the unavailability of cash for people trapped in the corralito compounded with the continuous loss of value of their savings, and the unresponsiveness of the appeal authorities (minor courts and the Supreme Court itself) further angered the protesters. A cacerolazo in Buenos Aires, Argentina during the night of December 19, 2001. The first cacerolazos were spontaneous and non-partisan. While in Argentina most demonstrations against government measures are customarily organized by labour union activists and low-level political recruiters among the lower classes, and often featuring an assortment of large banners, drums and pyrotechnic devices, cacerolazos were composed mostly of spontaneously gathered middle-class workers, who otherwise had little to no involvement in grassroots political actions of any kind.

On July 1, 2014, Schiff took over as president of the Council on Crime and Justice (CCJ), a Minneapolis nonprofit organization established in 1957 to "create a criminal justice system that is equitable and just." The CCJ dismissed Schiff in 2015 and closed suddenly in 2016 after almost 60 years of operation. A federal audit conducted on a grant program that was frozen while Schiff led the CCJ identified a misuse of funds at the organization. Schiff stated that he believed that the CCJ's board of directors and its previous leadership were responsible for the council's shutdown, although two consultants with the CCJ said they believed Schiff's inaction and unresponsiveness during his tenure with the organization led to the freezing of the grant, one of the organization's largest sources of revenue.

Heterologous desensitization (also known as cross-desensitization) is the term for the unresponsiveness of cells to one or more agonists to which they are normally responsive. Typically, desensitization is a receptor (biochemistry)-based phenomenon in which one receptor type, when bound to its ligand, becomes unable to further influence the signalling pathways by which it regulates cells and, in the case of cell surface membrane receptors, may thereafter be internalized. The desensitized receptor is degraded or freed of its activating ligand and re-cycled to a state where it is again able to respond to cognate ligands by activating its signalling pathways. This type of desensitization, termed homologous desensitization, leaves a cell transiently unresponsive to agents that activate the desensitized receptor but not to agents that activate other receptors.

Physochlaina species have a long history of use in the systems of traditional medicine of Tibet and Mongolia as drugs having powerful anti-inflammatory effects against skin diseases and sexually transmitted diseases, in addition to their beneficial effects – both soothing and energizing – upon nervous disorders. Khaidav, Z. and Menschikova, T. (eds) (1978) Lekarstvenie rastenia v Mongolskoi medizine Academia Nauk MNR, Ulaanbaatar. In the traditional system of classification of herbal drugs in Mongolian folk medicine, the plant is described as "bitter in taste with a cool, oily potency". It is used currently as an "antibacterial", an analgesic, an anticonvulsant, an antipyretic, an anti-parasitic, against anthrax, against encephalitis, against glanders, against parasitic worms of the skin and the gastrointestinal tract against tumors and to treat sexual unresponsiveness, aspermia, abdominal pain and hypothermia.

A still unusual optional extra from August 1963 was disc brakes on the front wheels, fitted for an extra 195 DM. Press comment in a country where technical innovation generates enthusiasm was very positive in respect of the car's status as the world's first production car to be fitted with a belt driven camshaft, but criticised the unresponsiveness of the standard drum brakes and the heavy clutch. The car's tendency to pitch under acceleration or sharp braking which was attributed to its short wheel base also drew criticism as did the “back to front” gear box which, as on the existing Isar, had originally been intended for a (never produced except as a prototype) front-wheel-drive small car and accordingly positioned first and third gears nearest to the driver, with second and fourth gears nearest the front of the car.

He expanded the proposed realm of factors that contribute to deindividuation, beyond anonymity and loss of personal responsibility, to include: "arousal, sensory overload, a lack of contextual structure or predictability, and altered consciousness due to drugs or alcohol," as well as "altered time perspectives...and degree of involvement in group functioning" Zimbardo postulated that these factors lead to "loss of identity or loss of self-consciousness," which result in unresponsiveness to external stimuli by the individual and the loss of "cognitive control over motivations and emotions." Consequently, individuals reduce their compliance with good and bad sanctions held by influences outside the group. Zimbardo was consistent with Festinger et al. in his suggestion that loss of individuality leads to a loss of control, causing affected persons to behave intensely and impulsively, having let go of internal restraints.

In 1953, American gynecologist John Morris provided the first full description of what he called "testicular feminization syndrome" based on 82 cases compiled from the medical literature, including two of his own patients. The term "testicular feminization" was coined to reflect Morris' observation that the testicles in these patients produced a hormone that had a feminizing effect on the body, a phenomenon now understood to be due to the inaction of androgens, and subsequent aromatization of testosterone into estrogen. A few years before Morris published his landmark paper, Lawson Wilkins had shown through experiment that unresponsiveness of the target cell to the action of androgenic hormones was a cause of "male pseudohermaphroditism". Wilkins' work, which clearly demonstrated the lack of a therapeutic effect when 46,XY patients were treated with androgens, caused a gradual shift in nomenclature from "testicular feminization" to "androgen resistance".

Despite his quiet persona, Father Stone's presence dominates those around him, leading to awkward and protracted silences which suck the life out of the room, ruining Ted's birthday party as a result. His unresponsiveness makes him practically impossible to get rid of, causing Ted and the others to go to great lengths just to avoid contact with him, such as going to bed extremely early or going out to the island's sub-standard crazy golf course in the pouring rain. When Ted prays to God with the intention of getting rid of Father Stone, he is subsequently struck by lightning after joining Ted and Dougal at the crazy golf course. He gets stuck in the same position as he was when he is struck, and surgeons are unable to remove the golf club from his hands, leading Dougal to comment: "He looks like a trophy".

On March 1, 2008, Toronto Star business and consumer affairs columnist Ellen Roseman reported on Bloomex online complaints, offering one customer's experience with a promised same-day delivery as an example of company unresponsiveness. In a follow-up Star column the next week, company president Lokhonia examined Roseman's late-delivery example, explaining that the order was entered past the deadline for same-day delivery, it was delivered according to the company's published terms and conditions, and the company never refunds delivery charges in such cases in order to maintain its low prices.Toronto Star, "Same price, but fewer tax returns" (second section), March 8, 2008 Lokhonia also alleged that some complaints were actually written by small retail florists in competition with Bloomex,Toronto Star, "'Wecare' doesn't tell the real tale" , March 1, 2008 a statement that drew fresh online complaints.Ellen Roseman, "Online florist Bloomex pays attention to online gripes", July 15, 2008 In June 2008, Bloomex issued a press release admitting that the company had made mistakes in the past due to unexpectedly strong sales growth, and announced new systems to improve customer satisfaction.

CI-966 (developmental code name) is a central nervous system depressant acting as a GABA reuptake inhibitor, specifically a highly potent and selective blocker of the GABA transporter 1 (GAT-1) (IC50 = 0.26 μM), and hence indirect and non-selective GABA receptor full agonist. It was investigated as a potential anticonvulsant, anxiolytic, and neuroprotective therapeutic but was discontinued during clinical development due to the incidence of severe adverse effects at higher doses and hence was never marketed. In a phase I human clinical trial while under development for the treatment of epilepsy, CI-966 was assessed at doses of 1–10 mg, 25 mg, and 50 mg. While the 1–10 mg dosages were well tolerated, the 25 mg dose produced memory deficits and the 50 mg dose was found to produce "a variety of severe neurological and psychiatric symptoms" and "serious psychotic adverse effects" of prolonged (several-day) duration and demonstrated "severe adverse CNS symptoms such as memory deficits, myoclonus and tremors, unresponsiveness and subsequent severe psychological disturbances".

A distinct name has been given to many of the various presentations of AIS, such as Reifenstein syndrome (1947), Goldberg-Maxwell syndrome (1948), Morris' syndrome (1953), Gilbert-Dreyfus syndrome (1957), Lub's syndrome (1959), "incomplete testicular feminization" (1963), Rosewater syndrome (1965), and Aiman's syndrome (1979). Since it was not understood that these different presentations were all caused by the same set of mutations in the androgen receptor gene, a unique name was given to each new combination of symptoms, resulting in a complicated stratification of seemingly disparate disorders. Over the last 60 years, as reports of strikingly different phenotypes were reported to occur even among members of the same family, and as steady progress was made towards the understanding of the underlying molecular pathogenesis of AIS, these disorders were found to be different phenotypic expressions of one syndrome caused by molecular defects in the androgen receptor gene. AIS is now the accepted terminology for the syndromes resulting from unresponsiveness of the target cell to the action of androgenic hormones.

This idea of alienation can be observed in some other contexts, although the term may not be as frequently used. In the context of an individual's relationships within society, alienation can mean the unresponsiveness of society as a whole to the individuality of each member of the society. When collective decisions are made, it is usually impossible for the unique needs of each person to be taken into account. The American sociologist C. Wright Mills conducted a major study of alienation in modern society with White Collar in 1951, describing how modern consumption- capitalism has shaped a society where you have to sell your personality in addition to your work. Melvin Seeman was part of a surge in alienation research during the mid-20th century when he published his paper, "On the Meaning of Alienation", in 1959 (Senekal, 2010b: 7–8). Seeman used the insights of Marx, Emile Durkheim and others to construct what is often considered a model to recognize the five prominent features of alienation: powerlessness, meaninglessness, normlessness, isolation and self-estrangement (Seeman, 1959).

Over a series of 13 episodes produced and mostly written by Philip Mackie, Lewis portrayed Drusilla as a highly professional and, at first, rather prim, proper and somewhat icyIn the first episode, "The Bright Bomber", Donald Webster as John Halifax refers to Drusilla (to her face) as "frigid" (a word with overtones of sexual unresponsiveness), but quickly apologises and changes his description to "icy". assistant who had been through finishing school, had a shorthand speed of 150 words per minute,Episode, "The Noble Roman", broadcast 3 March 1967 but was unable (so she always said) to make decent coffee.Although Drusilla was required to cook infrequently, it transpired that she had achieved only "highly commended" for her domestic science at finishing school: episode, "The Honest Villain", 14 April 1967. However, despite her apparent hauteur, she was also beautiful,Sleeve notes, 2012 DVD (loc.cit.) attracting ready attention from men to whom Rose introduced her, and, in the first episode (broadcast 17 February 1967), her potential sexiness was hinted at by an unexpected scene in which Rose's manservant (Donald Webster as John Halifax) burst into her bedroom as she was about to put on a jumper over her bra and panties.

A first criticism directed towards NCM relates to the rational expectations hypothesis. Under this hypothesis, “people are assumed to know the policy rule used by the monetary (and fiscal) authorities and to have detailed knowledge about the structure of the economy including the size and timing of responses to shocks of various kinds. These assumptions make the models analytically tractable but, taken literally (as they often are), they distort the economist's view of the policy problem by ignoring uncertainty, incomplete knowledge about the structure of the economy and the costs of acquiring information and reducing uncertainty” (Brunner and Meltzer 1993, p. 42). A second criticism addressed by Brunner to NCM concerns the intertemporal concept of equilibrium: “I also have strong reservations about crucial aspects of their 'equilibrium approach' ” (Klamer 1984, p. 191). To the question “So what is wrong with new classical economics?”, Brunner answered: “Their interpretation of equilibrium analysis seems dubious to me. This specific kind of equilibrium analysis implies that all prices are market-clearing relative to all shock-realizations” (p. 192). As a result, NCM cannot explain “the lamented unresponsiveness of prices to current conditions” (Brunner 1980, p.

Cleckley then summarizes the material and provides a 'clinical profile', describing 16 behavioral characteristics of a psychopath (reduced from 21 in the first edition): Cleckley, pp.338-339 (5th ed.) #Superficial charm and good intelligence #Absence of delusions and other signs of irrational thinking #Absence of nervousness or psychoneurotic manifestations #Unreliability #Untruthfulness and insincerity #Lack of remorse and shame #Inadequately motivated antisocial behavior #Poor judgment and failure to learn by experience #Pathologic egocentricity and incapacity for love #General poverty in major affective reactions #Specific loss of insight #Unresponsiveness in general interpersonal relations #Fantastic and uninviting behavior with drink and sometimes without #Suicide threats rarely carried out #Sex life impersonal, trivial, and poorly integrated #Failure to follow any life plan. Some of the criteria have obvious psychodynamic implications, such as a lack of remorse, poor judgment, failure to learn from experience, pathological egocentricity, lack of capacity for love, a general poverty in major affective reactions, and lack of insight into his own condition. Starting in 1972, newer editions of the book reflected a closer alliance with Kernberg's (1984) borderline level of personality organization, specifically defining the structural criteria of the psychopath's identity integration, defensive operations and reality testing.