We might need to continuously release refractory mosquitoes—that is, the ones that aren't good at transmitting the disease in question—to overcome selection against the desirable refractory genes.
|
|
He began to use immunological therapy to treat relapsed, refractory Hodgkin's lymphoma.
|
|
But he believes that after a brief refractory period, the bull run will resume.
|
|
The drug secured approval for relapsed or refractory AML patients with an IDH210 mutation.
|
|
It's virtually impossible for men to have multiple ejaculatory orgasms with no refractory period.
|
|
The trial included adult patients with either relapsed or refractory B cell acute lymphoblastic leukemia.
|
|
While it's common for females to have this capacity, most males have a refractory period.
|
|
A majority of AML patients relapse or present with refractory disease and have overall poor prognosis.
|
|
JCAR015 is intended to be used to treat patients with relapsed or refractory acute lymphoblastic leukemia.
|
|
This is the refractory period, the blissed-out pause for pondering your recent foray into environmental eroticism.
|
|
SANOFI SA: Sanofi said on Monday FDA approved Sarclisa® for patients with relapsed refractory multiple myeloma.
|
|
The new research involved patients with relapsed or refractory AML who tested positive for the FLT20003 mutation.
|
|
Besponsa was approved to treat adults with relapsed or refractory B-cell precursor acute lymphoblastic leukemia (ALL).
|
|
The drug is being studied as a potential treatment for refractory generalized myasthenia gravis, a debilitating neuromuscular disease.
|
|
Analysts said the use of the drug in only TNF refractory patients could limit use more than expected.
|
|
This is because they have a refractory period, the period of time it takes to regain sexual sensitivity.
|
|
The Phase 1 clinical study demonstrated encouraging results in treating patients with late-stage relapsed-refractory multiple myeloma.
|
|
The trial, dubbed the "ROCKET" trial, focuses on adult patients with relapsed or refractory B cell acute lymphoblastic leukemia.
|
|
The drug, Idhifa, secured approval for relapsed or refractory AML patients who have an IDH2 mutation, the FDA said.
|
|
The company said it received FDA approval to treat adult patients with relapsed or refractory large B-cell lymphoma.
|
|
The DREAMM-1 study of patients with relapsed/refractory multiple myeloma confirmed the potential effectiveness of the medicine, GSK said.
|
|
Magnesita and RHI announced their plan to merge to create a new company specializing in fireproof refractory materials last October.
|
|
It's a tribute to the drug's muddled popular conception as a horse tranquilizer, club drug, and cure for refractory depression.
|
|
The trial involved adult patients with relapsed or refractory B cell acute lymphoblastic leukemia, and was known as the "ROCKET" trial.
|
|
But we do hear from physicians of stories of women who were refractory to treatment and are now having viable pregnancies.
|
|
There is growing competition in the CAR-T space, with Gilead's similar Yescarta approved for aggressive refractory adult lymphoma last October.
|
|
Almost a third endure refractory epilepsy, meaning typical pharmaceutical drugs have little effect in reducing the instances or frequency of seizures.
|
|
Amgen said the agency approved Kyprolis in combination with dexamethasone or with the drug lenalidomide plus dexamethasone for relapsed or refractory patients.
|
|
It approved the drug as a single agent for patients with relapsed or refractory disease who have received one or more treatments.
|
|
That may sound like refractory nonsense, but in fact it neatly describes many aspects of internet culture — in particular alt-right trolling.
|
|
As we all finally give birth, we're told to hold our babies against our breasts and calm down in this refractory period.
|
|
The late-stage trial was testing Sage's drug, brexanolone, in patients with super-refractory status epilepticus (SRSE) whose seizures persisted despite earlier treatments.
|
|
We've noted that Congress passing a law on net neutrality could, in theory, achieve the same goals and stop refractory debates surrounding neutrality.
|
|
The U.S. Food and Drug Administration has already approved Kyprolis for patients with relapsed or refractory multiple myeloma who have previously undergone treatment.
|
|
Celgene is working on an experimental new gene therapy designed to treat people with relapsed or refractory aggressive B-cell non-Hodgkin lymphoma.
|
|
A collection of new and old stories, published last year as "The Visiting Privilege" (Knopf), offered up a life's work of refractory brilliance.
|
|
The combo was approved for adults, who have received at least two prior therapies for relapsed or refractory form of non-Hodgkin's lymphoma (NHL).
|
|
Sage is also evaluating the drug for use in super refractory status epilepticus (SRSE), a life-threatening seizure disorder, as well as essential tremor.
|
|
But the HQ refractory period — six to 18 hours — is just long enough to relax you into a state of optimism about playing again.
|
|
Our systematic approach to research enabled the first-ever treatment (siltuximab) and discovery of a treatment for patients who are siltuximab-refractory, like me.
|
|
The combo is used to treat adults, who have received at least two prior therapies for relapsed or refractory form of non-Hodgkin's lymphoma (NHL).
|
|
Kyprolis has already been approved by the U.S. Food and Drug Administration for patients with relapsed or refractory multiple myeloma, who have previously been treated.
|
|
Seven-year-old Javiera suffers from refractory epilepsy, a form of epilepsy where typical medication does not work well—or at all—to control seizures.
|
|
Juno's drug is being evaluated in adults with relapsed or refractory B-cell acute lymphoblastic leukemia, a type of blood cancer with a very poor prognosis.
|
|
Petropavlovsk is close to bringing on technology to boost profits from the treatment of refractory gold ore, which is very hard to process using traditional methods.
|
|
The technique only works for refractory B-cell malignancies—so-called "liquid" blood cancers—such as acute lymphoblastic leukemia, chronic lymphocytic leukemia, and non-Hodgkin's lymphoma.
|
|
The agency also approved the drug as a single agent for patients with relapsed or refractory multiple myeloma who have received one or more previous treatments.
|
|
Refractory gold, which takes the form of gold particles disseminated throughout an ore body, rather like shale oil, is very difficult to extract using conventional methods.
|
|
What they do according to O*NET: Build or repair equipment such as furnaces, kilns, cupolas, boilers, converters, ladles, soaking pits, and ovens, using refractory materials.
|
|
Or will they retreat at the state and local level, as they have in the past, leaving this refractory terrain to their highly motivated Republican adversaries?
|
|
According to Swann, people with vulvas don't have a post-coital refractory period, which means that they remain sensitive to sexual stimuli and can achieve further orgasms.
|
|
With "No Rules," the show surveying Frankenthaler's woodcuts, the curator Jay Clarke demonstrates how well a refractory medium can suit an artist who favors intuition and chance.
|
|
Celgene is working with Seattle-based Juno on an experimental new gene therapy designed to treat people with relapsed or refractory aggressive B-cell non-Hodgkin lymphoma.
|
|
"Relapsed" disease means a patient achieved remission but the cancer returned, and "refractory" disease means chemotherapy didn't work and "the disease grew straight through it," Perl said.
|
|
Of course, the prospect of having harder erections, longer sessions, and shorter refractory times is going to be something many guys will want to take advantage of.
|
|
Karyopharm Therapeutics — Karyopharm announced in a conference call Wednesday afternoon that Xpovio, a drug aimed at treading refractory multiple myeloma, was approved by the Food and Drug Administration.
|
|
The Paris-based company, bought by Astorg in 2013, makes calcium aluminate cements, used in specialized concretes and mortars and in refractory linings in furnaces, amongst other applications.
|
|
Xospata tablets, approved Wednesday, are for the "treatment of adult patients who have relapsed or refractory acute myeloid leukemia (AML) with a FLT3 mutation," according to the FDA.
|
|
"I think it's an idea worth pursuing, particularly since psilocybin's been used in the treatment of other rather refractory disorders, for example post-traumatic stress disorder," he said.
|
|
Since 2012, Bobadilla and some other 20 mothers of children with refractory epilepsy, cancer, and other illnesses, have tried to spread the message of medical marijuana around Chile.
|
|
The company said its Alis medication had a successful trial and showed significant improvement for patients with treatment-refractory nontuberculous mycobacteria lung disease caused by Mycobacterium avium complex.
|
|
Keytruda is also approved to treat lung cancer, bladder cancer, advanced melanoma, as well as refractory classical Hodgkin lymphoma, a type of cancer that starts in white blood cells.
|
|
Sex educator Bianca Palmisano says scientists aren't 100 percent certain why this happens, but some hypothesise that the refractory period is regulated by hormones like like oxytocin and prolactin.
|
|
SANOFI Sanofi said the U.S. Food and Drug Administration has accepted for review the Biologics License Application for isatuximab for the treatment of patients with relapsed/refractory multiple myeloma.
|
|
And since other medical treatments for refractory endometriosis carry other risks, that surgical diagnosis is important for confirming the cause of the pain before those other options are tried.
|
|
For the new study, 247 patients with relapsed or refractory AML and the FLT33 mutation were randomly assigned to receive gilteritinib, and 124 similar patients were assigned to standard chemotherapy.
|
|
"Physiologically, guys have a much longer refractory period than women, but women can have an orgasm and then have another one fairly quickly, within the next couple minutes," Dr. Streicher says.
|
|
But ket, approved in the UK as an aesthetic and for pain relief, has also been explored by the medical community as a radical new way to treat severe, refractory depression.
|
|
His doctors think Daniel died of new onset refractory status epilepticus, or Norse, a rare seizure disorder in which healthy people with no history of epilepsy suddenly begin to seize uncontrollably.
|
|
The ambivalent effect points up an irony endemic to museum presentations of politically refractory art: whatever discontent the artists express is cushioned by their inclusion in—say it—élite institutional culture.
|
|
The company did report results for JCAR017 in a small number of patients with relapsed or refractory chronic lymphocytic leukemia, showing that 81 percent of them responded to the cell therapy.
|
|
Burnett does add, however, that what the recreational Viagra user is more likely to experience is a shorter refractory period—the time between ejaculating and being able to have sex again.
|
|
The change in management comes as the company works to capitalize on a long-running project to allow the treatment of refractory gold ore that is difficult to process using traditional methods.
|
|
The trial was testing Sage's drug, brexanolone, plus standard of care in patients with super-refractory status epilepticus (SRSE) whose seizures persisted despite earlier treatments, versus a placebo plus standard of care.
|
|
"Results from this case series indicate ACTH gel may be a safe and viable option for patients with refractory [rheumatoid arthritis] who have failed previous therapy with multiple RA treatments," Brown wrote.
|
|
This autumn, Mr. Wellhoefer said, Swarovski will introduce a new crystal product, called a Concise Crystal, that is 50 percent lighter than previous stones, allowing for even more encrustation and refractory gleam.
|
|
"The low mortality rate is all the more noteworthy as heroin-assisted treatment in Switzerland included only refractory opioid addicts with existing severe somatic and/or mental problems," the study's authors conclude.
|
|
For more news, click The company has broadened the indications for its Votubia drug, when the European Union approved its use to treat refractory partial-onset seizures in patients with tuberous sclerosis complex.
|
|
In one clinical trial, 2750 out of 2000 patients with relapsed and refractory acute lymphoblastic leukemia (ALL) were in remission after six months (four with the help of at least one other other therapy).
|
|
Rakishev says the new management would immediately get involved with a project named the pressure oxidation hub (POX) to allow the treatment of refractory gold ore that is difficult to process using traditional methods.
|
|
"There has been an urgent need for novel treatment options that improve outcomes for patients with relapsed or refractory B-cell precursor ALL," Novartis, the drug company that makes Kymriah, said in a statement.
|
|
ZURICH (Reuters) - Novartis has broadened the indications for its Votubia drug, the company said on Tuesday, when the European Union approved its use to treat refractory partial-onset seizures in patients with tuberous sclerosis complex.
|
|
Sanofi, whose shares have underperformed major rivals, reiterated its strategy to rebuild its position in cancer and said it expected a first regulatory submission of its monoclonal antibody for relapsed refractory multiple myeloma in 2018.
|
|
The EMA's Committee for Medicinal Products for Human Use (CHMP) recommended Nucala for use as an add-on treatment for severe refractory eosinophilic asthma in pediatric patients aged six up to 17 years, it said.
|
|
He said the trial did not show a big difference between patients whose leukemia was refractory, meaning they had stopped responding to treatment, and patients who had relapsed, or might have responded temporarily to chemotherapy.
|
|
She has learnt to extract enough oil from the 40 spiky-leafed plants for her 6-year-old son Jacobo and 30 other children suffering from chronic refractory epilepsy, which is resistant to conventional treatments.
|
|
Novartis said on Tuesday it requested Food and Drug Administration (FDA) approval for Kymriah for adult patients with relapsed or refractory diffuse large B-cell lymphoma (DLBCL) who do not qualify for a stem cell transplant.
|
|
The company is also targeting the several thousand people a year who have relapsed or refractory diffuse large B-cell lymphoma (DLBCL) diagnosed, but it will not file Kymriah for that group until later this year.
|
|
"Capitalists have entrenched themselves within the governments of the world and wield the machinery of state as the policeman does the baton and the revolver — to inspire fear, control the refractory and suppress revolt," Weaver wrote.
|
|
Calquence is currently approved for treating adults with relapsed or refractory mantle cell lymphoma in the United States, Brazil, UAE and Qatar, and is being developed for the treatment of chronic lymphocytic leukemia and other blood cancers.
|
|
The San Francisco Giants have won the World Series in even-numbered years going back to 2010, which makes Bruce Bochy the leader of a dynasty, albeit one that enjoys a very long refractory period between peaks.
|
|
Taksta™ is Cempra's second product candidate, which is being developed for acute bacterial skin and skin structure Infections (ABSSSI) and is also in an exploratory study for chronic oral treatment of refractory infections in bones and joints.
|
|
Three months after infusion, the overall response rate (ORR)among 51 adult patients with relapsed or refractory diffuse large B-cell lymphoma (DLBCL) was 45 percent, Novartis said, with 0173 percent complete responses (CR), or no sign of disease.
|
|
"The merging of gene therapy, synthetic biology and cell biology is providing new treatment options for patients with refractory malignancies and represents a novel class of therapeutics with the potential to transform cancer care," noted Riddell in a statement.
|
|
If negotiations between Iraq and the U.S./NATO make adjustments in how foreign forces operate in Iraq, the U.S. and NATO should be clear the Iranian-controlled "Faction PMU" and other refractory groups are considered to be unfriendly forces.
|
|
An independent data monitoring committee recommended an increase in the number of patients to 450 from currently 330 in the ongoing trial named B-MIND, which tests the tafasitamab drug against relapsed or refractory diffuse large B cell lymphoma.
|
|
Juno had disclosed last Thursday that two people in the trial had died after the company added the chemotherapy drug fludarabine to the regimen in the trial, which involves adult patients with relapsed or refractory B cell acute lymphoblastic leukemia.
|
|
Another way to reduce what reaches the ground is to substitute refractory materials such as titanium and steel, used to make things like fuel tanks and fly wheels, with substances such as aluminium and graphite epoxy that vaporise more easily.
|
|
In a completed randomized Phase 2 study in recurrent/refractory cervical cancer, AXAL showed apparent prolonged survival, objective tumor responses, and a manageable safety profile alone or in combination with chemotherapy, supporting further development of the Company's Lm Technology™.
|
|
The London-listed firm, which has underperformed peers for about a decade, is near the end of a quest to bring on technology to boost profits from the treatment of refractory gold ore, which is very hard to process using traditional methods.
|
|
Cambridge, Massachusetts-base Sage is working on a drug to treat super refractory status epilepticus (SRSE), a common life-threatening neurological disorder that occurs when seizures last more than five minutes or when more than one seizure occur in a five-minute period.
|
|
In August, the Swiss multinational Novartis won approval to offer Kymriah (tisagenlecleucel) for the treatment of patients 2475 and younger who have relapsed twice, or whose B-cell precursor acute lymphoblastic leukemia (ALL) has been dubbed refractory, meaning stubborn or resistant to treatment.
|
|
I added that if he wanted to continue sporting the crowbar-like erection and fleeting refractory period of men less than half his age, that he may want to think about going straight and getting above-board sildenafil delivered to his door.
|
|
The drug, administered intravenously, has been approved for use in adults at a fixed dose of 200 mg and in children at a dose of 2 mg/kg for refractory classical Hodgkin lymphoma, a type of cancer that starts in white blood cells.
|
|
"Outcomes with traditional standard of care for this highly refractory patient population have been extremely poor," said Dr. Sattva Neelapu, co-lead investigator on the trial and professor of lymphoma and myeloma at the University of Texas MD Anderson Cancer Center in Houston.
|
|
"The primary analysis of the first Phase III study of Venclexta in relapsed/refractory CLL shows a profound improvement in PFS versus standard bendamustine/Rituxan, with consistent effects in all-risk subsets," researchers concluded in a brief summary of interim data released on Tuesday.
|
|
Rather than tune out, America might best use this refractory period to meditate on the difference between a calm week here and a standard week in Europe—and the ways in which we might learn to mirror that continent's consistently lower mass shooting casualties.
|
|
A 2007 study showed that sildenafil is both a safe and effective way to treat premature ejaculation, while research published in early 20133 found that sildenafil shortened the refractory period by an average of 11 minutes for men who are around 32 years old.
|
|
Kymriah, already approved for treatment of children and young adults with r/r B-cell acute lymphoblastic leukemia, will now get speedy scrutiny for use against relapsed or refractory (r/r) diffuse large B-cell lymphoma (DLBCL) in adults, the company said in a statement.
|
|
"We now know that Kyprolis not only significantly extended progression-free survival compared to Velcade, but also overall survival, making it a clinically meaningful advance in the treatment of relapsed or refractory multiple myeloma," Dr. Meletios Dimopoulos, one of the study's lead investigators, said in a statement.
|
|
The list price is 282,000 pounds ($369,000) per patient, given as a single intravenous infusion, but Novartis agreed to offer the therapy for relapsed or refractory diffuse large B-cell lymphoma (DLBCL) at a confidential discounted price, the National Institute for Health and Care Excellence (NICE) said.
|
|
I originally wrote these out to illustrate that Star Wars movies will suffer from diminishing returns, to show that our taste for nostalgia would fade with time, and to suggest that a more relaxed release schedule may give us the necessary refractory period to appreciate a new film.
|
|
In this connection, it is clearly counterproductive to launch into childish or ritualistic ad hominem attacks upon Kim Jong Un. Calling him "Rocket Man" may resonate usefully with the refractory political "base," but it could also encourage precisely the dangerous adversarial behavior we all so desperately seek to avoid.
|
|
CreditCreditEli Reed/Magnum Photos There are so many refractory facets to consider in the life of the vocal genius Marianne Faithfull once characterized as "the voice of God" that talking about Aretha Franklin's fashion sense feels a bit like speaking of Benjamin Franklin's knack for flying a kite.
|
|
Kymriah, already approved for treatment of children and young adults with r/r B-cell acute lymphoblastic leukemia (ALL), will now get speedy scrutiny by the U.S. Food and Drug Administration for use against relapsed or refractory (r/r) diffuse large B-cell lymphoma (DLBCL) in adults, the company said in a statement.
|
|
We can argue about which of these drugs represent transformative advances (a new medicine for breast cancer, tested on women with relapsed or refractory disease, increased survival by just a few months; a drug for a type of leukemia had a more lasting impact), but we know, roughly, the chain of events that unfolds when a trial is positive.
|
|
A breed of futurists who believe in enhancing or transcending the human condition using tech, they envision a world in which humans pop pills to eliminate refractory time between orgasms, link their brains to new and ineffable external robotic pleasure organs, or send out digital copies of their brains to have virtual sex before downloading those experiences into their bodies for a flood of perfect pleasure concentrate.
|
|