So no I don't see a specific risk in a prolongation.
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"There must be no prolongation — it has to happen now," Juncker said.
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"She is for prolongation of glyphosate for the next 10 years," he said.
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They thought that "we were secretly advocating for the prolongation" of oil and gas.
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Prolongation of the present relationship could be one option; temporary membership of the EEA another.
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Relatively mild weather has contributed to a prolongation of the fighting season in many places.
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Oil producers and the energy ministry have discussed a six-month prolongation, TASS news agency reported.
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However, a prolongation and/or a significant further deterioration in the political situation would create risks for banks.
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On transition, the reality has always been that nothing will be on offer except a prolongation of the status quo.
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That prolongation expired last August, and yet he remains in office—in the 11th year of an eight-year term.
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The prolongation of the war led to the rise of extremist groups the United States is now fighting in Syria.
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"There must be no prolongation — it has to happen now," he said of the deal, ruling out any extension of talks.
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This might not be after tonight, it may be after Wednesday when we have a ruling on No-Deal and prolongation.
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EXPANDS MCOT™ SERVICE TO MONITOR LIFE-THREATENING QT PROLONGATION IN COVID-19 PATIENTS Source text for Eikon: Further company coverage:
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Its label includes warnings for a possible heart condition, called QT prolongation, and liver toxicity that require monitoring that Pfizer's medicine has avoided.
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Mr Tokayev would ensure a smooth prolongation of his much-praised balanced foreign policy, while Ms Nazarbayeva would safeguard her father's business empire.
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"Result of today's vote in the Commons means prolongation of uncertainty, which is bad for all of us," Austrian Foreign Minister Karin Kneissl tweeted.
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Each tiny heave of the sweatshirt at PS1 is a meditation on both the end of life and its prolongation, aided by a respirator.
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He made his reluctance abundantly clear by attaching the formal request for a prolongation to a letter urging the bloc not to grant his request.
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Its miraculous prolongation of my existence, for which I am ever grateful, deepens my concern about those who will be unable to benefit from it.
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The three-month prolongation of the mission is meant to give more time to negotiators to find a compromise before a possible longer extension of Sophia.
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Whether epigastric lactation and its consequent prolongation of family life is confined to T. magnus, or is more widespread among jumping spiders, remains to be looked at.
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It remains to be seen how the Trump administration responds on key privacy issues over the longer term — such as the prolongation of Section 702 of FISA.
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Moreover, the absence of new safety issues — Kisqali already has warnings for so-called QT prolongation, which can signal heart and liver problems — will also be reassuring.
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"You are talking about prolongation of national service in response to ... continued belligerence by Ethiopia," he said referring to Eritrea's neighbor with a population of 215 million.
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Freeing performers from their chronological age need not be purely a matter of vanity, career prolongation or story continuity in franchises beset with both prequels and time travel.
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Speaking alongside Johnson on Thursday, European Commission President Jean-Claude Juncker said that there would be "no need for any kind of prolongation" if MPs back Johnson's agreement.
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Prolongation of the tense climate sparked by an initiative to reform the country's generous retirement system threatens to keep business confidence and investment subdued next year, economists said.
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Prolongation of the low-growth, low-interest-rate environment threatens to tighten the squeeze on bank earnings, hampering capital-raising efforts by some to continue building "bail-in" buffers.
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Juncker's claim that the agreement meant "there is no need for prolongation" prompted suggestions in London that the EU's most senior figure had ruled out any fresh delay to Brexit.
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That limitation, however, "is both a strength and a limitation, in a way ... because what we're estimating here is the prolongation of life expectancy just based on behaviors," Stampfer said.
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"Our emphasis is on reversal rather than longevity, in part because it's easier to get permission from the F.D.A. for reversal of diseases than for prolongation of life," he says.
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There are additive blood-thinning effects (fish oil or vitamin E taken with Coumadin), additive sedative effects (valerian used with antihistamines) and the prolongation or intensification of drug effects (St.
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According to Schneider, the non-prolongation of the lease is part of a wider cultural struggle within Kyiv, and that the city's independent cultural life is being strangled as a result.
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En France, plusieurs parents ont cependant fait part d'une soudaine dégradation de l'état de santé de leur enfant et d'un affaiblissement de leur système immunitaire nécessitant la prolongation de leur hospitalisation.
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The stark reality is that Moscow, whose policies openly benefit from prolongation of war, has used Nagorno-Karabakh to brutally undermine Armenia's sovereignty to the point that it has little remaining.
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"The Commission is in close and constructive contacts with the Italian authorities regarding the prolongation of the sale deadline for four Italian bridge banks," Commission spokesman Ricardo Cardoso said in an email.
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Otilia Dhand, an analyst at Teneo Intelligence political risk consultancy, said she expected policy continuity, especially on fiscal issues, with the prolongation of the coalition and the re-appointment of Vujovic as finance minister.
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Germany and several other northern European countries would like shorter extensions and no automatic prolongation, but instead quarterly reviews to make sure Greece is not reversing reforms agreed and implemented under the three bailouts.
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BRUSSELS, Sept 27 (Reuters) - The European Commission said on Friday it had approved the prolongation of the Belgian and French state guarantees for the debt of bailed-out Franco-Belgian lender Dexia beyond 2021.
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It is partially a prolongation of Alfred Barr's abstract art family tree of 1936, but the Tate chose to do away with all links to the world beyond art, something that Barr did include tangentially.
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The prolongation of the State of Emergency that was proclaimed in October 2016 for the first time in two decades illustrates the persistence of significant underlying tensions, despite the relaxation of some of its provisions.
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A statement issued by the Arab League's council warned of "the gravity of taking any unilateral steps ... in a manner that allows foreign military interventions and contributes to the escalation and prolongation of the conflict".
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Reminiscent of the IMF's mishandling of the Greek sovereign debt crisis, the Oversight Board is condemning the island to a multi-year prolongation of its economic slump by requiring of it draconian budget belt- tightening.
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Quiet and meditative, these pictures are an affirmation of life's everyday pleasures in the present moment by an artist who dedicated his artistic career to the prolongation of longing and the preservation of what he loved.
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"The tax reduction will be 3 billion crowns per year ... This tax relief is (for us) more pointed towards investments on the prolongation of Swedish nuclear," Vattenfall's chief executive Magnus Hall said in an interview on Friday.
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Like his predecessor, Trump is once again being pressed by military advisers to increase troop levels in Afghanistan -- albeit by lesser increments -- and commit to a multi-year prolongation of a war that has now spanned three presidents.
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The French Society for Palliative Care said in a statement on Monday that Mr. Lambert was in "a situation of artificial prolongation of life, as a result of medical action," and that taking him off life support was justified.
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"We observed that the reaction of oil markets to this prolongation of the OPEC agreement is a bit different to what markets expected, and the oil price is a bit lower than many expected as a result of this OPEC agreement," Nabiullina said.
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"The new rules allow the minister of justice to exert influence on individual ordinary judges through, in particular, the vague criteria for the prolongation of their mandates thereby undermining the principle of irremovability of judges," the European Commission said in a statement on Saturday.
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They wish to spare themselves and their loved ones the cruel suffering that attends so many slow deaths, and they know better than we do that the prolongation of suffering in the vain pursuit of another day is not the extension of a quality life.
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The president sent this message last weekend, for example, in a long interview with Megyn Kelly of NBC, in which he indicated that Russia is ready to consider a prolongation of the Strategic Arms Reduction Treaty or even a new agreement with further reductions.
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"The illegal prolongation of the rescue aid to Tirrenia for one year, beyond the six months duration foreseen, is incompatible (with EU rules)," the Commission said in a statement, also citing illegal use of funds to keep the business running, rather than for vessel upgrades.
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After chairing a meeting of EU counterparts in Amsterdam, the Dutch migration minister said they expected an unprecedented prolongation of the time governments can impose border checks because the migrant crisis would not be under control before current, short-term dispensations expire in May.
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"We expect a constructive outcome to todays meeting in terms of a prolongation of the deal, but are not yet convinced that a strong bullish surprise with a sizeable adjustment to the target level will really transpire," Vienna-based consultancy JBC Energy said in a note.
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With inflation already missing the ECB's target of almost 2 percent for more than 4-1/2 years, a further delay could fuel arguments for a prolongation of ECB stimulus, even as the 19-member currency bloc's economy is enjoying its best upswing since before the global financial crisis.
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While in Japan, the indefatigable Trump weighed in, mostly on Twitter, on post-election Israeli politics, slammed Democrats for getting "NOTHING" done, demanded a change in libel laws and called for a prolongation of the annual Rolling Thunder Vietnam veterans event in Washington, which is expected to wrap up this year.
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"If you need to reconsider how the Brexit referendum should be respected; what would be the preferred U.K. choices, I don't see a risk in a prolongation … I think it's never a risk to think twice and to sleep on it then sometimes you wake up and you reconsider," she said.
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On this EP, each track relates to a separate issue brought about by the prolongation of life through technological/scientific means, whether this would be about how this extension affects the "value" of life; or at what point there is a dependence on technology to retain life; or even the physical realities of this rise in longevity.
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Out of it short-term debt is 31.9 billion roubles, company should pay it off during 12 months - company's presentation ** Significant part of the debt falls on Gazprom, liabilities for which are planned to be extended, Osin said during conference call for analysts **"Major part of the repayment - Gazprom, three billion (roubles) - commercial credit, it will be refinanced" - Osin said **According to the manager, as a result of debt prolongation interest rate may raise from about 8 pct to about 10 pct ** Company's management said that 2016 investment programme as whole will be amounted to 19.5 billion roubles, 11.7 billion roubles of which have been already invested in H1.
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Side effects may include sleepiness or QT prolongation. Significant prolongation has not yet been observed at recommended dosage levels, however, those taking inhibitors of the liver enzymes CYP2D6 or CYP3A4 – or who are poor CYP2D6 metabolizers – may be at risk for significant prolongation.
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The finding of QTc prolongation in astronauts has been of concern from the clinical operations perspective. Such prolongation has been documented on several occasions but it is not clear if these findings have any clinical significance or portend risk.
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The latter is geologically its western prolongation, already within the Region of Murcia.
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The postcava enters the liver in a special prolongation of the liver substance.
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John Rothgeb (New York: Longman, 1982), p. 54. Prolongation can be thought of as a way of generating musical content through the linear elaboration of simple and basic tonal structures with progressively increasing detail and sophistication.William Drabkin. "Prolongation." Grove Music Online.
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67, Music and the Cognitive Sciences. McAdams, Stephen and Irene Deliege, eds. . Lerdahl's own formulation of prolongation is more amenable to atonal structures. For example, in atonal music, strong prolongation may be distinguished from progression, repetition of an event versus movement to a different event, while weak prolongation, repetition of an event in altered form, may not easily be distinguished due to the lack of a referential triad (klang).
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Currently, Krimau appears every week in a TV Show called "Prolongation" on Arryadia TV.
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A possible cause could be the prolongation of REM sleep muscle atonia upon awakening.
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From it a prolongation is sent forward between the fourth and fifth metatarsal bones.
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Saint Stephen Parish is defined in the Territorial Division Act as being bounded: :South by Dufferin Parish and the St. Croix River; east by Saint David Parish, north and west by a line beginning in the intersection of the St. Croix River with the southwesterly prolongation of the northwestern limit of Lot No. 16, granted to Angus Rankin; thence northeasterly along said prolongation and said limit to the western limit of Lot No. 115, granted to Thomas Dodd; thence northerly along the western limits of Lots Numbered 115, 116, 117 and 99 to 114 inclusive to the southern limit of Lot No. 46 granted to Thomas Grimmer Junior; thence westerly along said limit and its prolongation to the eastern limit of Lot No. 60, granted to Robert M. Todd; thence northerly along the eastern limit of Lot No. 60 and its northerly prolongation, to meet the westerly prolongation of the northern limit of No. 53 granted to Peter Christie; thence easterly along said westerly prolongation, the northern limit of Lot No. 53 and the easterly prolongation of the northern limit of Lot No. 53, to the eastern bank or shore of Moore Lake.
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A carpophore is a prolongation of receptacle or axis between the carpels and bearing them.
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Schenker Studies 2, p.178. . He formulated four conditions for the possibility of Schenkerian prolongation in any musical style (1987)Straus, Joseph N. (1987). "The Problem of Prolongation in Post- Tonal Music", Journal of Music Theory 31, p. 1-21. cited in Lerdahl (1989).
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Prolongation of homotransplant viability under the influence of thio-TEPA and thio-TEPA combined with hydrocortisone.
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The Medes Islands further east, beyond the town of l'Estartit, are a geological prolongation of this massif.
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Selpercatinib can cause serious side effects including liver toxicity, high blood pressure, heart rhythm changes due to prolongation of heart electrical activity (QT prolongation), bleeding, allergic reactions, impaired wound healing and harm to an unborn baby. Selpercatinib may cause harm to a developing fetus or a newborn baby.
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See Schenkerian analysis:The fundamental line. Prolongation (), Composing-out, Elaboration : The process in tonal music through which a pitch, interval, or consonant triad is able to govern spans of music when not physically sounding. Schenker himself appears to have used the German term Prolongation mainly to describe extensions of the laws of strict counterpoint to freer writing: see Prolongation in Heinrich Schenker. Auskomponierung can be literally translated as "composing-out"; the German word is coined on the model of Ausarbeitung, "elaboration".
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A tendency for prolongation of half-lives was noted in patients with cardiomyopathy and in patients with arrhythmias.
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Colonial literature is a prolongation of the parental literature and is at first commentative and imitative of that.
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TV Nova [online]. 12 October 2016. Available online. Due to its success the tour's prolongation was announced in December.
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In these people, exercise or adrenaline infusion can lead to paradoxical prolongation of the QT interval, revealing the underlying condition.
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Brandt, Anthony K. "Ariadne's Lament". Liner notes. New World Records. Her compositional style is characterized by modality, imitation, and prolongation.
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The Kuomintang Islamic insurgency in China (1950–1958) was a prolongation of the Chinese Civil War in several provinces including Gansu.
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The eastern prolongation of the Anti-Atlas is the Jbel Saghro range. The Jbel Sirwa is its northern prolongation, connecting with a section of the High Atlas range. The summit of Jbel Sirwa, of volcanic origin, reaches 3304 m. The Jbel Bani is a much lower range running along the southern side of the Anti Atlas.
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Structural Hearing: Tonal Coherence in Music, p. 267. . Music theorist Robert Morgan has argued that a central tenet of Schenkerian thought—that only consonant triads are capable of prolongation—needlessly excludes a class of dissonant sonorities, such as diminished sevenths or a more arbitrarily defined set of pitches; Morgan claims that, starting in the 19th century, composers such as Liszt, Wagner, and Scriabin, began "composing out" these dissonant configurations as rigorous a manner as is usually ascribed to the triadic prolongation of tonal composers.Morgan, Robert (1976). "Dissonant Prolongation: Theoretical and Compositional Precedents" in Journal of Music Theory 20/1, 49–91.
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Chord of nature : See Klang. Composing out : See Prolongation. Compound melody : See Unfolding. Coupling () : "The connection of two registers which lie an octave apart".
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Oxford Music Online. 2 Aug. 2011 . Important to the operation of prolongation is the hierarchical differentiation of pitches within a passage of tonal music.
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Common side effects include headache, dizziness, and nausea. Other side effects include QT prolongation. It has not been studied in pregnancy as of 2016.
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Side effects are uncommon. Concerns include the possibility of QT prolongation. Versions are available for use in children. Use in early pregnancy is not recommended.
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The fluoroquinolones, including ciprofloxacin, are associated with an increased risk of cardiac toxicity, including QT interval prolongation, torsades de pointes, ventricular arrhythmia, and sudden death.
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Possible side effects include cardiac effects such as bradycardia and QT interval prolongation. Also, possible central nervous system toxicity has been shown in animal studies.
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Foreign nations have the freedom of navigation and overflight, subject to the regulation of the coastal states. Foreign states may also lay submarine pipes and cables. ; Continental shelf: The continental shelf is defined as the natural prolongation of the land territory to the continental margin's outer edge, or from the coastal state's baseline, whichever is greater. A state's continental shelf may exceed until the natural prolongation ends.
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It ends below at the summit of the medial condyle, in a small tubercle, the adductor tubercle, which affords insertion to the tendon of the adductor magnus. From the medial lip of the linea aspera and its prolongations above and below, the vastus medialis arises; and from the lateral lip and its upward prolongation, the vastus lateralis takes origin. The adductor magnus is inserted into the linea aspera, and to its lateral prolongation above, and its medial prolongation below. Between the vastus lateralis and the adductor magnus two muscles are attached: the gluteus maximus inserted above, and the short head of the biceps femoris arising below.
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This may be related to the potentiation and prolongation of muscle twitch caused by the inhibition. The mechanism of biotransformation of PTX 251D is still unknown.
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After a one-and- half season loan prolongation, he ended his contract with Cruz Azul and failed to continue at La Paternal, being released in December 2011.
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Carleton Parish is defined in the Territorial Division Act as being bounded: :Westerly by the eastern line of lot no. 124, granted to F.J. Richard, in block ten, range eight; its southern prolongation to the Saint-Louis Parish line; and its northern prolongation to the County line; south by Saint-Louis Parish; northwest by the County line; and east by the Gulf of Saint Lawrence, including the islands in front.
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He used the word mainly to denote the transformation of a given level of voice-leading to the next one, describing the passage from level to level as a Prolongation. Adele T. Katz appears to be responsible for the shift of meaning where "prolongation" became the American translation of Auskomponierung, "elaboration".Adele T. Katz (1935). "Heinrich Schenker's Method of Analysis", The Musical Quarterly 21/3, pp. 311-329.
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The village is situated on the prolongation of the runway 07R/25L of the Brussels Airport. Its geographical coordinates are 50° 54' 0" North, 4° 34' 0" East.
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Westfield Parish is defined in the Territorial Division Act as being bounded: :On the northwest, south and west, by the boundary line of the County; and on the northeast by a line beginning on the County line between Kings and Queens, intersected by the northwestern prolongation of the line dividing lots number twenty-three and number twenty- four at Devils Back, on the Long Reach; thence southeasterly along said prolongation and line to the northwestern shore of the Long Reach; thence southeasterly in a direct line across the Saint John River to the line dividing lots number twenty-five and number twenty-six, granted to Robert and Caleb Merritt; thence southeasterly along said line and its southeastern prolongation to the rear line of lots fronting on the northwest side of Kennebecasis Bay; thence southwesterly along said line to the northeast line of lot number twenty-eight, granted to Dennis Coombe; thence southeasterly along said line and its southeastern prolongation to the County line, including Kennebecasis Island.
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In 2001, the FDA changed the labeling requirements for droperidol injection to include a Black Box Warning, citing concerns of QT prolongation and torsades de pointes. The evidence for this is disputed, with 9 reported cases of torsades in 30 years and all of those having received doses in excess of 5 mg. QT prolongation is a dose-related effect, and it appears that droperidol is not a significant risk in low doses. A study in 2015 showed that droperidol is relatively safe and effective for the management of violent and aggressive adult patients in hospital emergency departments in doses of 10mg and above and that there was no increased risk of QT prolongation and torsades de pointes.
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E-4031 is solely used for research purposes. So far, one clinical trial has been conducted to test the effect of E-4031 on prolongation of the QT-interval.
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13 (1922), pp. 101-102 during the Primo dictatorship they enjoyed favorable treatment.see e.g. the 1928 decision related to prolongation of Lezama’s mining concessions, La Voz de Asturias 25.03.
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Later in August, Russia obtained a prolongation period from Kyrgyzstan, allowing Russian military sites to remain for 15 more years after the expiration of the current contract in 2017.
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Solifenacin is also not recommended for use in people with severe liver failure, clinically significant bladder outlet obstruction in the absence of clean intermittent catheterization, decreased gastrointestinal motility (slowed intestinal contractions), or at high risk of QT prolongation (an electrical disturbance where the heart muscle takes longer than normal to recharge between beats), including people with a known history of QT prolongation and people taking medications known to prolong the QT interval.
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British Columbia's position is based on the principle of natural prolongation which developed in international law. It poses a dilemma for the federal government of Canada. If Canada holds that the principle of natural prolongation applies to the Juan de Fuca Canyon on its Pacific Ocean coast, the assertion could undermine Canada's argument in the Gulf of Maine boundary dispute. In this Atlantic Ocean context, Canada favours an outcome based on the principle of equidistance.
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The suture is rather deep and well- defined, showing the gradual formation and prolongation of the slit. The aperture is oblong. The siphonal canal is short. There is no umbilicus.
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The eighth and ninth were both held on 23 November on a limited prolongation of some price controls and a federal resolution on bread supply. Both were approved by voters.
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Pankhurst, Tom (2008). Schenker Guide: A Brief Handbook and Website for Schenkerian Analysis, p. 28. . Bass prolongation: I–IV–V–I as elaboration of I–V–I .Pankhurst (2008), p. 51.
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It also has special neurologic indications for Tourette syndrome and resistant tics. The side effects include akathisia, tardive dyskinesia, and, more rarely, neuroleptic malignant syndrome and prolongation of the QT interval.
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Dysphoria, sedation, hypotension resulting from peripheral alpha adrenoceptor blockade, prolongation of QT interval which can lead to torsades de pointes, and extrapyramidal side effects such as dystonic reactions/neuroleptic malignant syndrome.
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The DETools package uses the prolongation of vector fields for searching Lie symmetries of ODEs. Finding Lie symmetries for ODEs, in the general case, may be as complicated as solving the original system.
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CCB toxicity can cause a number of electrocardiogram abnormalities with a low sinus rhythm being the most common. Others include: QT prolongation, bundle branch block, first-degree atrioventricular block, and even sinus tachycardia.
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The hindwings are grey, with a blotch of fuscous somewhat modified scales extending over the dorsal three-fifths of the wing on the basal half, with an obscure prolongation in the disc posteriorly.
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This is similar to the re-entrant circuits that are the cause of atrial flutter and the re-entrant forms of supraventricular tachycardia. Other rarer congenital causes of monomorphic VT include right ventricular dysplasia, and right and left ventricular outflow tract VT. Polymorphic ventricular tachycardia, on the other hand, is most commonly caused by abnormalities of ventricular muscle repolarization. The predisposition to this problem usually manifests on the ECG as a prolongation of the QT interval. QT prolongation may be congenital or acquired.
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No indications of permanent neurotoxicity were observed. QT prolongation was also observed with very high doses of tamoxifen. There is no specific antidote for overdose of tamoxifen. Instead, treatment should be based on symptoms.
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Because it enables a pitch or pitches to remain in effect over the course of a piece, even as many other harmonic events intervene, prolongation is central to the concept of tonality in music.
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Biological Sciences. The prolongation of coagulation (or prothrombin time, PT) occurs following either tissue factor or contact-phase stimulation and is dose- dependent. CU-2010 acts as an effective contact-phase inhibitor at antifibrinolytic concentrations.
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Enhances effects of CNS depressants e.g. alcohol, barbiturates, hypnotics, opioid analgesics, anxiolytics and antipsychotics. Can mask signs of ototoxicity caused by aminoglycosides. QT prolongation (which can lead to torsades de pointes arrhythmia) reported with spiramycin.
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Straus concludes that such conditions do not exist in atonal music and therefore that "atonal prolongation" is impossible. However, theorist Lerdahl argues that Straus' argument is based on circular criteria.Lerdahl, Fred (1989). "Atonal Prolongational Structure", p.
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Pronounced prolongation of APD during a slow heart rate can lead to proarrythmias. Overall, HBI-3000 seems to have a low proarrhythmic risk. The effect of HBI-3000 on contractility and cardiac conduction requires further investigation.
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The Hedberg and Gardiner Lines Under the United Nations Convention on the Law of the Sea, party states may submit claims to the Commission on the Limits of the Continental Shelf to extend its continental shelf beyond the 200-mile buffer that comprises a state’s exclusive economic zone. This requires that the proposed extension be a natural prolongation of the state’s continental shelf, which can be concluded through bathymetric mapping and analysis. If a state can prove that a subsea formation is a natural prolongation of its continental shelf, it must consequently locate the foot of the slope, the physical boundary between the natural prolongation and the abyssal plain of the ocean basin. The foot of the slope is then applied to two equations that inform the claim made by a state for the legal extension of its continental shelf.
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The most common side effects associated with famotidine use include headache, dizziness, and constipation or diarrhea. Famotidine may contribute to QT prolongation, particularly when used with other QT-elongating drugs, or in people with poor kidney function.
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Brunswick Parish is defined in the Territorial Division Act as being bounded: :Southeast, east and northeast by the County lines; west by Johnston Parish, and northwest by the northeasterly prolongation of the northwest line of Johnston Parish.
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It also inhibits a number of transporter proteins and could thus theoretically interfere with the transport of other drugs in the body. It could also amplify QT prolongation of other drugs such as antiarrhythmics, clarithromycin, and haloperidol.
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Imposing integrability conditions on a particular G-structure (for instance, with the case of a symplectic form) can be dealt with via the process of prolongation. In such cases, the prolonged G-structure cannot be identified with a G-subbundle of the bundle of linear frames. In many cases, however, the prolongation is a principal bundle in its own right, and its structure group can be identified with a subgroup of a higher-order jet group. In which case, it is called a higher order G-structure [Kobayashi].
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Atonal music poses a stark challenge to prolongational hearing and analysis, as its harmonic makeup by definition eschews the long-range controlling force of monotonality, and in most cases purposely abstains from consonant triads, or indeed referential or centric sonorities at all. Music theorist Joseph Straus has attempted to define more rigorously what it is about atonality that precludes prolongational hearing. His own definition of prolongation is "the sense of continuation of a musical object, particularly when not literally present ... prolongation is a cognitive act of the listener".Schachter, Carl and Hedi Siegel, eds. (2006).
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Lasiognathus amphirhamphus is a species of wolftrap angler found in the Madeira Abyssal Plain in the east-central Atlantic Ocean where it occurs at a depth of from . The females of this species grow to a length of SL. This species is characterized by having only two (as opposed to three) bony hooks on its esca, which are lightly pigmented. The distal escal appendage is elongated and cylindrical with a long, compressed prolongation at the tip as in L. saccostoma. The prolongation has six tiny filaments at the tip and no lateral serrations.
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Johnston Parish is defined in the Territorial Division Act' as being bounded: :Southwest by Wickham and Cambridge Parishes; northwest by the prolongation of a line running north fifty-four degrees east by the magnet of the year one thousand seven hundred and eighty-six, from the west angle of the grant to Samuel Hughes, at Lower Cambridge; east by the east line of lot number eleven, granted to A.C. Starrit, on the north side of the Canaan River above Coles Island and its northern and southern prolongation, and southeast by the County line.
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While some have QT intervals that are very prolonged, others have only slight QT prolongation, or even a normal QT interval at rest (concealed LQTS). Those with the longest QT intervals are more likely to experience TdP, and a corrected QT interval of greater than 500 ms is thought to represent those at higher risk. Despite this, those with only subtle QT prolongation or concealed LQTS still have some risk of arrhythmias. Overall, every 10 ms increase in the corrected QT interval is associated with a 5% increase in arrhythmic risk.
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However, subsequent evidence such as the relatively common finding of variants in the gene in those without long QT syndrome, and the general need for a second stressor such as hypokalaemia to be present to reveal the QT prolongation, has suggested that this gene instead represents a modifier to susceptibility to QT prolongation. Some therefore dispute whether variants in KCNE2 are sufficient to cause Romano-Ward syndrome by themselves. LQT9 is caused by variants in the membrane structural protein, caveolin-3. Caveolins form specific membrane domains called caveolae in which voltage-gated sodium channels sit.
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Serious side effects may include QT prolongation. It is unclear if use during pregnancy or breastfeeding is safe. Hydroxyzine works by blocking the effects of histamine. It is a first generation antihistamine in the piperazine family of chemicals.
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Wilmot Parish is defined in the Territorial Division Act as being bounded: :North by the Westerly prolongation of the northern boundary of Simonds Parish; west by the County line; south by Wakefield Parish and east by Simonds Parish.
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Balmoral Parish is defined in the Territorial Division Act as being bounded: :West by Addington Parish; north by Dalhousie Parish; south by Northumberland County line, and east by the southern prolongation of the eastern line of Dalhousie Parish.
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Given an exterior differential system defined on a manifold M, the Cartan- Kuranishi prolongation theorem says that after a finite number of prolongations the system is either in involution (admits at least one 'large' integral manifold), or is impossible.
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Other side effects include QT prolongation. It has not been studied in pregnancy as of 2016. Delamanid works by blocking the manufacture of mycolic acids thus destabilising the bacterial cell wall. It is in the nitroimidazole class of medications.
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The Lushai Hills are frequently discussed with the Chin Hills as the topography, people's culture and history are similar. The southern prolongation of the Chin Hills is the Arakan Range (Arakan Yoma), stretching as well from north to south.
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Alfuzosin should be used with caution in patients with severe chronic kidney disease, and should not be prescribed to patients with a known history of QT prolongation or those who are taking medications known to prolong the QT interval.
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Noribogaine is a hERG inhibitor and appears at least as potent as ibogaine. The inhibition of the hERG potassium channel delays the repolarization of cardiac action potentials, resulting in QT interval prolongation and, subsequently, in arrhythmias and sudden cardiac arrest.
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The range is located in Buryatia, with a small section in Irkutsk Oblast. It rises near the Baikal Mountains not far from Lake Baikal. It forms a geographic prolongation of the Sayan Mountains. The highest peak is Utulinskaya Podkova at .
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Arrhythmias due to medications have been reported since the 1920s with the use of quinine. In the 1960s and 1970s problems with antihistamines and antipsychotics were discovered. It was not until the 1980s that the underlying issue, QTc prolongation was determined.
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Serious side effects may include angioedema, urinary retention, and QT prolongation. Use in pregnancy and breastfeeding are of unclear safety. It works by blocking muscarinic receptors in the bladder thus decreasing bladder contractions. Tolterodine was approved for medical use in 1998.
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The synovial membranes between the second and third, and the third and fourth metatarsal bones are part of the great tarsal synovial membrane; that between the fourth and fifth is a prolongation of the synovial membrane of the cuboideometatarsal joint.
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In August 2011, the FDA announced, “Citalopram causes dose-dependent QT interval prolongation. Citalopram should no longer be prescribed at doses greater than 40 mg per day”."Abnormal heart rhythms associated with high doses of Celexa (citalopram hydrobromide)". Safety Communication.
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Opposite the metatarsophalangeal articulation, the tendon gives off a thin prolongation on either side, to cover the surface of the joint. An expansion from the medial side of the tendon is usually inserted into the base of the proximal phalanx.
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Additionally, a long-term study showed that the Cardiac Contractility Modulation was able to stop the common and prognostically unfavorable long-term prolongation of QRS duration in heart failure patients. This result was interpreted as signaling the safety of the treatment and as an indicator that patients could benefit from Cardiac contractility modulation therapy in the long term. If the QRS-stabilizing effect were to be confirmed in further studies, the Cardiac Contractility Modulation would become the first device-based treatment for heart failure with the potential to halt QRS prolongation, a factor associated with a poor prognosis.
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The PAIGC opposed the extension, while the PRS and the United Social Democratic Party (PUSD) supported it."Le Conseil d’Etat demande la non prolongation du mandat des députés Bissau guinéens", African Press Agency, April 15, 2008 . A group of 20 deputies who opposed the extension said on 15 April that the extension was a violation of the Constitution and that they would not participate in any parliamentary sessions after 21 April;"La prolongation du mandat des députés divise les parlementaires bissau-guinéens", African Press Agency, April 15, 2008 . meanwhile, the Council of State asked the Assembly to reverse the extension.
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However, there is uncertainty as to whether some of the other rarer subtypes are truly disease-causing by themselves or instead make individuals more susceptible to QT prolongation in response to other factors such as medication or low blood potassium levels (hypokalaemia).
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For some historians the First Republic was a progressive and increasingly democratic regime. For others it was essentially a prolongation of the liberal and elitist regimes of the 19th century. A third group chooses to highlight the regime's revolutionary, Jacobin and dictatorial nature.
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The pisohamate ligament is a ligament in the hand. It connects the pisiform to the hook of the hamate. It is a prolongation of the tendon of the flexor carpi ulnaris. It serves as part of the origin for the abductor digiti minimi.
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Alcohol in combination with nitrazepam may cause a synergistic enhancement of the hypotensive properties of both benzodiazepines and alcohol. Benzodiazepines including nitrazepam may inhibit the glucuronidation of morphine, leading to increased levels and prolongation of the effects of morphine in rat experiments.
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The port has known important works of extension including the prolongation of the two facilities for phosphates shipping and the completion of citrus fruits facility in 1950's until the 1980s. Many other works are ongoing since 2013, ordered by the Marsa-Maroc.
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Caution is advised in patients with hypokalaemia, hypomagnesaemia, congenital long QT syndrome, or with coadministration of medicines known to cause QT prolongation. In combination with capecitabine, reversible decreased left ventricular function are common (2%).NCI Cancer Drug Information. FDA Approval for Lapatinib Ditosylate (Tykerb®).
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Nonspecific inhibitors like the lupus anticoagulant usually are not time dependent; the immediate mixture will show prolongation. Many specific factor inhibitors are time dependent, and the inhibitor will not be detected unless the test is repeated after incubation (factor VIII inhibitors are notorious for this).
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Saint-Paul Parish is defined in the Territorial Division Act as being bounded: :North by the western prolongation of the northern line of Wellington Parish; east by the McLaughlin Road;Route 490 west by the Canadian National Railways Line, and southwest by the County line.
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Common side effects include dry mouth, constipation, and urinary tract infection. Severe side effects may include urinary retention, QT prolongation, hallucinations, glaucoma, and anaphylaxis. It is unclear if use is safe during pregnancy. It is of the antimuscarinic class and works by decreasing bladder contractions.
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Like chloroquine, piperaquine can prolong the QT interval. Although large randomized clinical trials have not revealed evidence of cardiotoxicity, the World Health Organization recommends not using piperaquine in patients with congenital QT prolongation or who are on other drugs that prolong the QT interval.
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There are concerns of higher rates of QT prolongation and torsades de pointes compared with other SSRIs.Drugs To Avoid 2017 PDF Download The U.S. Food and Drug Administration and Health Canada did not similarly order restrictions on escitalopram dosage, only on its predecessor citalopram.
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Coverdale Parish is bounded on the east and north by the Petitcodiac River, on the west by the county line, and on the south by the prolongation of the southern line of Lot number 2 at the mouth of Stoney Creek, granted to Robert Crossman.
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The tunes of collected versions vary. The standard tune now associated with it is derived from a 1909 arrangement of a traditional folk melody by English composer Frederic Austin, who introduced the familiar prolongation of the verse "five gold rings" (now often "five golden rings").
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By itself it is sold in a long-acting formulation. Common side effects include dizziness, sleepiness, nausea, and constipation. Serious side effects may include abuse, low blood pressure, seizures, QT prolongation, respiratory depression, and serotonin syndrome. Rapidly decreasing the dose may result in opioid withdrawal.
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More generally, differential invariants can be considered for mappings from any smooth manifold X into another smooth manifold Y for a Lie group acting on the Cartesian product X×Y. The graph of a mapping X -> Y is a submanifold of X×Y that is everywhere transverse to the fibers over X. The group G acts, locally, on the space of such graphs, and induces an action on the k-th prolongation Y(k) consisting of graphs passing through each point modulo the relation of k-th order contact. A differential invariant is a function on Y(k) that is invariant under the prolongation of the group action.
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45 of the same volume. Schenker stresses that it starts with the two-voice setting of the Ursatz – an expression, therefore, of the fundamental laws of strict counterpoint. Each of the following steps is described as a Prolongation, a specific freedom taken with respect to the laws expressed in the previous step. And in Freie Satz, he confirms that the word still refers to the passing from one voice-leading level to another: "For the sake of continuity with my earlier theoretical and analytical works, I am retaining in this volume the words of Latin derivation Prolongation and Diminution as designations for the voice-leading levels in the middleground".
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A variety of drugs can present prolongation of the QT interval as a side effect. Prolongation of this interval is a result of a delay in sodium and calcium channel inactivation; without proper channel inactivation, the threshold potential is reached prematurely and thus arrhythmia tends to result. These drugs, known as pro-arrhythmic agents, include antimicrobials, antipsychotics, methadone, and, ironically, antiarrhythmic agents. The use of such agents is particularly frequent in intensive care units, and special care must be exercised when QT intervals are prolonged in such patients: arrhythmias as a result of prolonged QT intervals include the potentially fatal torsades de pointes, or TdP.
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Although long QT syndrome is often a genetic condition, a prolonged QT interval associated with an increased risk of abnormal heart rhythms can also occur in people without a genetic abnormality, commonly due to a side effect of medications. Drug- induced QT prolongation is often a result of treatment by antiarrhythmic drugs such as amiodarone and sotalol, antibiotics such as erythromycin, or antihistamines such as terfenadine. Other drugs which prolong the QT interval include some antipsychotics such as haloperidol and ziprasidone, and the antidepressant citalopram. Lists of medications associated with prolongation of the QT interval such as the CredibleMeds database can be found online.
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Con-G reduces the strength of excitotoxic intracellular Ca2+ actions and blocks different neuronal injuries in vitro. In certain injuries Con-G shows an exceptional prolongation of the therapeutic window. Con-G can reverse established allodynia and can also fully reverse thermal hypersensitivity induced by nerve injury.
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Serious side effects include akathisia, tardive dyskinesia and the potentially fatal neuroleptic malignant syndrome. Mesoridazine was withdrawn from the United States market in 2004 due to dangerous side effects, namely irregular heart beat and QT-prolongation of the electrocardiogram. It currently appears to be unavailable worldwide.
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Treatment for brain metastases is primarily palliative, with the goals of therapy being reduction of symptoms and prolongation of life. However, in some patients, particularly younger, healthier patients, aggressive therapy consisting of open craniotomy with maximal excision, chemotherapy, and radiosurgical intervention (Gamma Knife therapy) may be attempted.
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Common side effects include vomiting, diarrhea, rash, and increased liver enzymes. Serious side effects may include liver problems, QT prolongation, and seizures. During pregnancy it may increase the risk of miscarriage while large doses may cause birth defects. Fluconazole is in the azole antifungal family of medication.
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Timothy syndrome is a rare autosomal-dominant disorder characterized by physical malformations, as well as neurological and developmental defects, including heart QT-prolongation, heart arrhythmias, structural heart defects, syndactyly (webbing of fingers and toes), and autism spectrum disorders. Timothy syndrome often ends in early childhood death.
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Saint James Parish is defined in the Territorial Division Act as being bounded: :South by Saint Stephen Parish and Saint David Parish; east by the northerly prolongation of the east line of Saint David Parish; north by the County line; and west by the St. Croix River.
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Between Marquisat and Belaygue a major fault zone crosses in a NW-SE direction. This fault zone is a prolongation of the Mareuil anticline. In some high places the Cretaceous sediments are covered by alluvial and colluvial deposits of the Pleistocene, mainly sands, gravels and clays.
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Common side effects include nausea, vomiting, headache, and trouble sleeping. Other side effects may include QT prolongation, psychosis, and low white blood cells. It is unclear if use during pregnancy or breast feeding is safe. Fexinidazole is in the antiparasitic and the nitroimidazole family of medications.
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Weldford Parish is defined in the Territorial Division Act as being bounded: :South by Saint-Paul and Sainte-Marie Parishes; west by the prolongation of a line running north twenty-two degrees west by the magnet of the year one thousand eight hundred and sixty-seven, from a point on the County line between Westmorland and Kent Counties, distant twenty miles from the north point of Shediac Island; east and north by a line beginning at a point on the westerly prolongation of the northern line of Wellington Parish, at the intersection of a line running south from the mouth of Black Brook; thence northerly along said line to the mouth of Black Brook; thence down the East Branch of and the main Saint Nicholas River to the Richibucto River, thence up said river to the west line of lot number 9, granted to William Harley; thence northerly along said line and its northerly prolongation to the rear line of the Richibucto River Indian Reserve number 15; thence by a line running true west to the western boundary of the parish.
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Sussex Parish is defined in the Territorial Division Act as being bounded: :West and south by a line running south from the mouth of Halfway Brook to the Old Westmorland Road; thence easterly in a direct line to a point distant seventy chains on a course north by the magnet of the year one thousand eight hundred and fifteen, from the northeastern angle of lot number one, granted to Samuel DeForest; thence by a line running in a direct course to the northeastern angle of lot fifty-five, granted to William Thompson, on the north side of Shepody Road, until it intersects the eastern side line of lot number thirty, granted to Henry Douglas, or its prolongation; east by the eastern side line of the said grant to Henry Douglas and its northerly prolongation until it strikes Trout Creek; thence up stream to the southwestern angle of lot number seven, granted to Simon Armstrong; thence north, following the western side line of last-mentioned grant and its northerly prolongation to the Kennebecasis River and north by the centre of the Kennebecasis River.
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Lapatinib-Related Rash and Breast Cancer Outcome in the ALTTO Phase III Randomized Trial.J Natl Cancer Inst. 2016 Apr In clinical studies elevated liver enzymes have been reported. QT prolongation has been observed with the use of lapatinib ditosylate but there are no reports of torsades de pointes.
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More serious side effects include problems with QT prolongation, heart block, high blood lipids, and liver problems. It appears to be safe in pregnancy. It is in the protease inhibitor class and works by blocking the HIV protease. Saquinavir was patented in 1988 and first sold in 1995.
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Antacids containing aluminium or magnesium ions inhibit the absorption of moxifloxacin. Drugs that prolong the QT interval (e.g., pimozide) may have an additive effect on QT prolongation and lead to increased risk of ventricular arrhythmias. The international normalised ratio may be increased or decreased in patients treated with warfarin.
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The southern border of Veternička Rampa is Novosadski put (Novi Sad Road), the eastern border is Ulica Somborska rampa (Somborska Rampa Street), the northern border is a prolongation of the Bulevar Vojvode Stepe (Vojvoda Stepa Boulevard), and the western border is a western city limit of Novi Sad.
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To define a diffiety, we need to take a geometric approach to the description of differential equations and their solutions. This requires the notions of jet spaces, prolongation, and Cartan distribution which will be introduced below. The reader familiar with those notions can directly proceed to the definition.
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The means of elaboration are described below as "prolongational techniques", in conformity with the modern Schenkerian English usage, but should better be termed "elaborations". The broadening of the meaning of "prolongation" has been described by Anthony PopleAnthony Pople, "Using Complex Set Theory for Tonal Analysis: An Introduction to the 'Tonalities' Project", Music Analysis 23/2-3 (2004), pp. 162-164. Pople describes "prolongation" as "a Humpty-Dumpty Word". in seven steps: (1) Schenker proposes it as an operational concept in his teaching; (2) Salzer,Structural Hearing, 1952/1962 Forte1959: "Schenker's Conception of Musical Structure", Journal of Music Theory 3/1, 1959. and others, disseminate and clarify it; (3) it is used within attempted formalisations of Schenkerian analysis;e.g.
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For example, 0.6 kg mean weight change after 6 months of treatment with escitalopram for depression was insignificant and similar to that with placebo (0.2 kg). Citalopram and escitalopram are associated with dose-dependent QT interval prolongation and should not be used in those with congenital long QT syndrome or known pre-existing QT interval prolongation, or in combination with other medicines that prolong the QT interval. ECG measurements should be considered for patients with cardiac disease, and electrolyte disturbances should be corrected before starting treatment. In December 2011, the UK implemented new restrictions on the maximum daily doses at 20 mg for adults and 10 mg for those older than 65 years or with liver impairment.
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The malnutrition and associated changes in salt balance develop over a prolonged period of time, and rapid refeeding may further disturb the salt imbalances, increasing the risk of arrhythmias. Care must therefore be taken to monitor electrolyte levels to avoid the complications of refeeding syndrome. Factors which prolong the QT interval are additive, meaning that a combination of factors (such as taking a QT-prolonging drug and having low levels of potassium) can cause a greater degree of QT prolongation than each factor alone. This also applies to some genetic variants which by themselves only minimally prolong the QT interval but can make people more susceptible to significant drug-induced QT prolongation.
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Use is not recommended in those with structural heart disease or ischemic heart disease. Flecainide is a class Ic antiarrhythmic agent. It works by decreasing the entry of sodium in heart cells, causing prolongation of the cardiac action potential. Flecainide was approved for medical use in the United States in 1985.
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Maugerville Parish is defined in the Territorial Division Act as being bounded: :Southwest by the Saint John River; northwest and northeast by the County lines, and southeast by the lower line of lot numbered four, granted to Nathaniel Underhill and D. Palmer, junior, and its northeastern prolongation, including Oromocto Island.
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Burton Parish is defined in the Territorial Division Act as being bounded: :Southeast by the County line; southwest by the prolongation southeasterly of the southwest line of Lincoln Parish to the Queens County line; northwest by the Oromocto River and northeast by the Saint John River, including Gilbert and Ox Islands.
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He wrote later, "War weariness was written in the emaciated faces. The mood had become dark, sad and tragic. There was a generalized anti-communist resentment because many believed the communists to be responsible for the war's prolongation." At the end of the war Azcárate went into exile in Paris.
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Serious side effects may include low blood pressure, liver problems, psychosis, and QT prolongation. It is unclear if use in pregnancy and breastfeeding is safe. It is an α2-adrenergic agonist and how it works is not entirely clear. Tizanidine was approved for medical use in the United States in 1996.
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Common side effects when applied to the skin include redness. Common side effects when taken by mouth include nausea, headache, and liver problems. Liver problems may result in death or the need for a liver transplantation. Other severe side effect when taken by mouth include QT prolongation, adrenocortical insufficiency, and anaphylaxis.
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Some towns are located at the foot of the Tagant Plateau's slopes, which form cliffs in some places. Among these areas are Tichit, Moudjéria and Rachid. Tidjikdja lies on the Tagant itself. The Assaba Massif, where Late Ordovician glacial formations have been identified, is a southward prolongation of the Tagant plateau.
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Bright Parish is defined in the Territorial Division Act as being bounded: :Northwest by the County line; northeasterly by Douglas Parish; southeasterly by the Saint John River, and southwesterly by the northeast line of lot number fifty-nine, granted to Jonathan Williams, and its northwesterly prolongation to the County line.
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Legs slender, the protibia with a pointed apical prolongation on the outer side, greatly distally expanded to distally expanded and shovel-like; male and female tarsi identical, the basal 4 segments of the anterior tarsi are as broad as they are long, usually slightly asymmetrical. Type species: M. sculpturatum Blanchard 1853.
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Common side effects include muscle and joint pains, fever, loss of appetite, and headache. Serious side effects include prolongation of the QT interval. While not well studied, it appears to be safe for use in pregnancy. The dose does not need changing in those with mild or moderate kidney or liver problems.
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Features that affect maritime boundaries include islands and the submerged seabed of the continental shelf. The process of boundary delimitation in the ocean encompasses the natural prolongation of geological features and outlying territory. The process of establishing "positional" borders encompasses the distinction between previously resolved and never-resolved controversies.Koo, Min Gyu. (2010).
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There are three pairs of these lateral appendages situated along the margin of the sides. These appendages have a ramified apex. Each ramification of the apex has a rounded base and a long, thin and sharp prolongation. The whole length of each of these appendages is covered by little and acute ramifications.
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ECG changes resembling those of an STEMI in a woman who had an acute CNS injury from a subarachnoid hemorrhage. Electrocardiographic changes are relatively common in subarachnoid hemorrhage, occurring in 40–70 percent of cases. They may include QT prolongation, Q waves, cardiac dysrhythmias, and ST elevation that mimics a heart attack.
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It was verified that bilastine 20 and 100 mg administered during 4 days, does not induce significant changes in the QT/QTc interval duration in any of the individuals. Likewise, coadministration of bilastine 20 mg and ketoconazol 400 mg does not produce any significant prolongation of the QT/QTc interval attributable to bilastine.
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The range extends for about in a roughly NW/SE direction just north of the Syrdaria River. The Muyunkum Desert lies to the north of the range. The Karatau is the westernmost prolongation of the Tian Shan. The summits of the mountains are smooth and the slopes are cut by snow-fed rivers.
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The size of the neuron can also affect the inhibitory postsynaptic potential. Simple temporal summation of postsynaptic potentials occurs in smaller neurons, whereas in larger neurons larger numbers of synapses and ionotropic receptors as well as a longer distance from the synapse to the soma enables the prolongation of interactions between neurons.
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This risk was proportional to the degree of PR prolongation. A subset of individuals with the triad of first-degree heart block, right bundle branch block, and either left anterior fascicular block or left posterior fascicular block (known as trifascicular block) may be at an increased risk of progression to complete heart block.
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It can be taken by mouth or intravenously with doses once per day. Common side effects include nausea, vomiting, diarrhea and upset stomach. An allergic reaction, such as anaphylaxis, QT prolongation, or a type of diarrhea caused by Clostridium difficile is possible. No harm has been found with its use during pregnancy.
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Other serious side effects may include QT prolongation, sudden death, pancreatitis, and liver problems. It is not safe for use during pregnancy. Nilotinib is a Bcr-Abl tyrosine kinase inhibitor and works by interfering with signalling within the cancer cell. Nilotinib was approved for medical use in the United States in 2007.
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Brighton Parish is defined in the Territorial Division Act as being bounded: :South-east by the County line; south by Northampton Parish; westerly by the Saint John River, and northerly and northwesterly by a line commencing at the upper line of lot number sixty-one, granted to John Flanagan in the grant to William Turner and others, and its easterly prolongation, until it meets the rear line of the first tier of lots on the north side of the Becaguimec River; thence along the said rear line and its prolongation north-easterly to the Cold Stream; and thence following the centre of the same up stream to the southerly boundary of Aberdeen Parish; and thence easterly along the boundary of Aberdeen Parish to the County line.
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Botsford Parish is defined in the Territorial Division Act as being bounded: :Northeast by Northumberland Strait, south by Baie Verte; west by Westmorland CountyThe word County did not occur in the previous Revised Statutes of New Brunswick. What's meant here is Westmorland Parish; the error occurred when the Revised Statutes of New Brunswick were updated in 1973. The boundary actually runs along a prolongation of the Westmorland Parish line until it strikes the boundary between Shediac Parish and Sackville Parish. and a line running magnetic south by the year eighteen hundred and twenty-four to Cumberland grant line, or its northerly prolongation from the northeast angle of a tract of fourteen hundred acres, granted to Thomas Doiron and others, at the mouth of Tedish River.
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1975; 34: 612 in which patient plasma and normal plasma are mixed and aPTT measured; correction of prolonged aPTT suggests a factor deficiency while persistent prolongation indicates the presence of an inhibitor. Prolongation of the aPTT in a mixture of patient and normal plasma after a 1-2 h incubation compared to an immediate mix is typical of FVIII autoantibodies, as FVIII inhibitors are time and temperature- dependent. The diagnosis is confirmed by the subsequent identification of reduced FVIII levels with evidence of FVIII neutralising activity (titrated using the Bethesda assay or the Nijmegen modification).Verbruggen B, Novakova I, Wessels H, Boezeman J, van den Berg M, Mauser-Bunschoten E. The Nijmegen modification of the Bethesda assay for factor VIII:C inhibitors: improved specificity and reliability.
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The great tarsal synovial membrane is a synovial membrane in the foot. The synovial membranes between the second and third, and the third and fourth metatarsal bones are part of the great tarsal synovial membrane; that between the fourth and fifth metatarsal bones is a prolongation of the synovial membrane of the cuboideometatarsal joint.
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Common adverse effects in studies were temporary bradycardia (slow heartbeat), usually at the beginning of the treatment, dyspnoea (breathing difficulties), and increased liver enzymes (without symptoms). No significant increase of infections was observed under ponesimod therapy. QT prolongation is detectable but was considered to be too low to be of clinical importance in a study.
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Two types of appendages are observed. The first type of appendages are longer and wider and are positioned at the margin of the sides of the animal. These appendages have apical ramifications that are rounded at the base with a long, thin and sharp prolongation. Small acute ramifications cover the remaining parts of the appendage.
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In the context of Schenkerian analysis, it appears among others in Forte & Gilbert, Introduction to Schenkerian Analysis (1982), Chapter 3, pp. 67-80. Manfred Bukofzer, Music in the Baroque Era, New York, Norton, 1947, had spoken of "implied polyphony". Unfolding is "a prolongation by means of the unfolding of intervals horizontally."Pandey, Ashish (2005).
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The short half-life of dienogest relative to other 19-nortestosterone progestins is in part due to its lack of binding to SHBG and hence prolongation in the circulation. The clearance of dienogest is 3 L/h. It is eliminated mainly in the urine, both as sulfate and glucuronide conjugates and as free steroid.
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Clarendon Parish has very regular boundaries: on the east by Queens County, on the south by a due west line from the southernmost corner of Queens County, on the north by the county line, and on the west by the prolongation of the rear line of grants along Lake Utopia in Saint George Parish.
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Serious side effects may include a decrease in white blood cell count, which can increase the risk of serious infections that could lead to death; numbness, tingling or burning in the hands and feet (neuropathy); harm to a developing fetus; as well as changes in heartbeat (QTc prolongation), that may also lead to death.
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The forewings are pale fuscous, the costal half and terminal area are suffused with rather dark fuscous. The stigmata are cloudy and dark fuscous, with the plical beneath the first discal, these obscured by a prolongation of the costal suffusion, the second discal distinct. The hindwings are pale grey, thinly scaled and darker grey posteriorly.
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Serious side effects include QT prolongation, liver dysfunction, and an increased risk of death. While harm during pregnancy has not been found, it has not been well studied in this population. It is in the diarylquinoline antimycobacterial class of medications. It works by blocking the ability of M. tuberculosis to make adenosine 5'-triphosphate (ATP).
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The Tamá is a prolongation of the Cordillera Oriental of the Colombian Andes. It is separated from the Cordillera de Mérida in the Venezuelan Andes by the Táchira depression, which more than 50 million years ago was a strait that connected Lake Maracaibo with the Orinoco basin. Elevations range from . Average annual temperature is .
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Wakefield Parish is defined in the Territorial Division Act as being bounded: :North by the lower line of lot numbered thirty-eight, granted to David Good, and the westerly prolongation thereof; westerly by the County line; south by Woodstock and Richmond Parishes, and east by the Saint John River, including all the islands in front.
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Class III agents predominantly block the potassium channels, thereby prolonging repolarization. More specifically, their primary effect is on IKr. Since these agents do not affect the sodium channel, conduction velocity is not decreased. The prolongation of the action potential duration and refractory period, combined with the maintenance of normal conduction velocity, prevent re-entrant arrhythmias.
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The butyl and butyryl syllables both refer to butane with one of its terminal methyl groups substituted. The half-life of BCHE is approximately 10 to 14 days. BCHE levels may be reduced in patients with advanced liver disease. The decrease must be greater than 75% before significant prolongation of neuromuscular blockade occurs with succinylcholine.
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Common side effects include nausea, trouble sleeping, sexual problems, shakiness, feeling tired, and sweating. Serious side effects include an increased risk of suicide in those under the age of 25, serotonin syndrome, glaucoma, and QT prolongation. It should not be used in someone on a MAO inhibitor. Antidepressant discontinuation syndrome may occur when stopped.
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Most anti-arrhythmic medications exert their effects by decreasing the permeability of potassium ion channels (IKr) in heart cells. These potassium channel blockers delay ventricular repolarization and prolong action potential duration (APD; the prolongation of the electrical stimulus within heart cells). These changes can lower heart rate, eliminate atrial fibrillation, and ultimately sudden cardiac death.
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Today, Mobitz I heart block is characterized by progressive prolongation of the PR interval on consecutive beats followed by a blocked P wave (i.e., a dropped QRS complex). After the dropped QRS complex, the PR interval resets and the cycle repeats. This grouped beating was described as "Luciani periods" after Luigi Luciani's work in 1873.
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A pochette is distinguishable from the rest of the violin family due to the fact that the neck is an prolongation of the body, instead of simply being attached to it. The Fellowship of Makers and Restorers of Historical Instruments has expressed that a pochette's strings ought not to be longer than ten inches.
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Average altitude is asl with peaks over asl and width averages at about . The Sierra Atravesada is a prolongation of the Sierra Madre de Chiapas. This range is not as high as the other two with an average elevation of just over . Most of it is located in the Juchitán district running east–west.
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This mountain range is located at the eastern end of the Iberian System and the Sierra del Toro its ESE prolongation. Its highest point is Javalambre (2,020 m). Its summits are usually covered in snow in the winter and the 1,839 m high Cerro Calderón or Alto de las Barracas is the highest peak of the Land of Valencia.
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In the study, half of the participants had to have their dose lowered due to a high incidence of dissociative side effects at the higher doses. Development was stopped due to incidence of QTc prolongation. Other NR2B subunit-selective antagonists of the NMDA receptor are still under development for depression, such as rislenemdaz (CERC-301, MK-0657).
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All that remains of the original construction as part of the current building is the Moorish-style roof, which can be seen in the prolongation of the choir towards the side naves. The church was rebuilt in 1714, with the patronage of with Gertrudis de la Peña, Marquesa de las Torres de Rada, and designed by Pedro de Arrieta.
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Schematic representation of the Baetic System of mountain ranges 1,956 m high Aguilón del Loco, one of the highest peaks in Sierra de Cazorla The Prebaetic System ( or Sistema Prebético, also often referred to simply as PrebéticoEmbalse del Taibilla) is a system of mountain ranges that forms the northeasternmost prolongation of the Baetic System in the southern Iberian Peninsula.
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The harmony, meanwhile, is a dominant prolongation in C (minor), and indeed, the orchestra resolves to C (major) in the following measure. Poulenc's vocal writing shows a strong dedication to maintaining the dramatic effect of Cocteau's text. The recitative-like passages clearly deliver the libretto, while the aria-like passages illustrate the soprano's passion and anguish.
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54–57 . The last part of the development section is called the Retransition: It prepares for the return of the first subject group in the tonic, most often through a grand prolongation of the dominant seventh. In addition, the character of the music would signal such a return. Exceptions include the first movement of Brahms's Piano Sonata No. 1.
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This interconnectivity of deflationary policy amongst so many nations resulted in the prolongation of the greatest economic downturn.Charles P. Kindleberger, The World in Depression, 1929–1939 (3rd ed. 2013) This article focuses on the economic milestones, with some mention of the political and social impact of the depression on nations and classes in a global context.
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On the same date, it was reported that the Amazon River was at 1.94 meters from its normal level. In Iquitos, Nanay and Itaya rivers were the cause of flooding. The areas most affected were the rural communities of Belén District, neighborhood and Bellavista-Nanay. Also main roads such as Prolongation Putumayo and La Marina Avenue were affected.
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Many generalizations exist to integrability conditions on differential systems which are not necessarily generated by one-forms. The most famous of these are the Cartan–Kähler theorem, which only works for real analytic differential systems, and the Cartan–Kuranishi prolongation theorem. See Further reading for details. The Newlander-Nirenberg theorem gives integrability conditions for an almost- complex structure.
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Rausenbaum M.B. et al. "The Mechanism of Intermittent Bundle Branch Block: Relationship to Prolonged Recovery, Hypopolarization and Spontaneous Diastolic Depolarization". Chest. 63 (1973) 666-677 This prolongation of the refractory period is related to a decreased sodium channel response in damaged tissue that shows an inactivation of sodium channels responsible for repolarization.Chiale P. A. et al.
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Mirror neurones of the frontal lobe are active during this exercise and act to link speech perception and production. This process combined with cortical priming is engaged to produce the visible response. Another primary characteristic of stuttering is a fixed posture, involving the prolongation of sounds. Speech shadowing research involving fixed postures produces no benefit in improving speech flow.
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This effect can be directly linked to QT prolongation mediated predominantly by inhibition of the hERG channel and, in some cases, augmentation of the late sodium channel.Yang, T., Chun, Y. W., Stroud, D. M., et al. Screening for Acute IKr Block is Insufficient to Detect Torsades de Pointes Liability: Role of Late Sodium Current. Circulation (2014) 130:224–234.
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The height of the shell is 9–17 mm (up to 20 mm). Apertural view of a shell of Oxyloma elegans Genitalia differences separate Oxyloma elegans from Oxyloma sarsii and the genus Succinea. The epiphallus is slightly curved and inside a short penis prolongation distance between penis and the pedunculus is very short.Species summary for Oxyloma elegans.
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Common side effects include a dry mouth, runny nose, upper respiratory tract infection, shortness of breath and headache. Severe side effects may include angioedema, worsening bronchospasm, and QT prolongation. Tentative evidence has not found harm during pregnancy, however, such use has not been well studied. It is an anticholinergic medication and works by blocking acetylcholine action on smooth muscle.
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Pimozide overdose presents with severe extrapyramidal symptoms, hypotension, sedation, QT interval prolongation and ventricular arrhythmias including torsades de pointes. Gastric lavage, establishment of a patent airway and, if necessary, mechanically assisted respiration is the recommended treatment for pimozide overdose. Cardiac monitoring should be continued for at least 4 days due to the long half-life of pimozide.
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Dixson demonstrated that increased baculum length is associated with primates who live in dispersed groups, while small bacula are found in primates who live in pairs. Those primates that have multi-male mating systems tend to have bacula that are larger in size, in addition to prolongation of post- ejaculatory intromission and larger relative testis size.
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The CrB score on the day of clinical appraisal significantly correlated with the number 6f days of treatment needed for remission. These results were in keeping with the hypothesis that eosinophils cause desquamation of respiratory epithelial cells resulting in prolongation of asthmatic attacks. Observation of CrB seemed to be useful as a marker of duration of asthmatic attacks.
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Low blood potassium, to levels of 1 to 2 mmol/L, may also occur. Cardiovascular abnormalities such as QRS complex widening and QT interval prolongation may also occur. Treatment recommendations include early mechanical ventilation, heart monitoring, and activated charcoal. Supportive treatment with intravenous fluids and vasopressors may be required with epinephrine being the vasopressor of choice.
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The 1965 Regulations expired in 1966. The state of emergency was then prolonged by the post-UDI legislature which also issued a series of new Emergency Regulations. Madzimbamuto's detention was renewed under these new Regulations. Madzimbamuto's wife, Stella, challenged the legality of her husband's detention on the ground that the prolongation of the state of emergency was unlawful.
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Canal Boulevard is located in the Lakeview area of New Orleans, Louisiana. It is a divided roadway that goes from City Park Avenue to Lake Pontchartrain. Canal Boulevard is a prolongation of Canal StreetLakeview, New Orleans which runs from the Mississippi River to City Park Avenue. As New Orleans expanded, the area of Lakeview was 'reclaimed' cypress swampland.
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Astemizole (marketed under the brand name Hismanal, developmental code R43512) was a second-generation antihistamine drug that has a long duration of action. Astemizole was discovered by Janssen Pharmaceutica in 1977. It was withdrawn from the market globally in 1999 because of rare but potentially fatal side effects (QTc interval prolongation and related arrhythmias due to hERG channel blockade).
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Studholm Parish is defined in the Territorial Division Act as being bounded: :West by Springfield Parish and the line running north from the mouth of the Halfway Brook; northwest by the County line; east by the western side line of the grant of nine hundred and ninety-seven acres to Thomas Leonard, the northern prolongation thereof to the County line, and the southerly prolongation thereof to Windgap Brook; thence following the several courses of said brook down stream until it intersects a line running south forty-two degrees thirty minutes east by the magnet of the year one thousand eight hundred and thirty-nine from the southwest angle of lot number one south granted to James Caruth; thence following the said last-mentioned line prolonged to Cardwell Parish, and south by Sussex and Cardwell Parishes.
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Pages 1-545.Metchnikoff E. The prolongation of life: optimistic studies. GP Putnam's Sons; 1908. Subsequently, the concept that microorganisms exist as single cells began to change as it became increasingly obvious that microbes occur within complex assemblages in which species interactions and communication are critical to population dynamics and functional activities.Bassler, B.L. (2002) "Small talk: cell-to-cell communication in bacteria".
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The Maghreb–Europe Gas Pipeline was first proposed in 1963 by French companies. This proposal foresaw prolongation of the pipeline to Strasbourg in France. However, because of the Western Sahara dispute, any route from Algeria through Morocco to Spain was prevented. Also natural gas consumption in Spain was too low to justify the pipeline construction. The project started in early 1990s.
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Assebroek is situated on a lower sand plain south west of Bruges. Forming a typical polder landscape, in winter an area called Assebroekse Meersen, characterised by small grass fields separated by willow trees often gets flooded. The Meersen area arose as prolongation within the so-called Flemish Valley. The slope contains sand, lime and peat deposits from the Holocene Epoch.
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Moncton Parish is defined in the Territorial Division Act as being bounded: :East by Shediac Parish; north by the County line, west by that part of the east line of the grant to Martin Gay and associates, which lies north of Petitcodiac River; and the northerly prolongation thereof, to the County line; southerly by the Petitcodiac River and Dorchester Parish.
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Sant'Andrea is a small island in the Venetian Lagoon, northern Italy. It houses the Forte di Sant'Andrea, a large fortress built in the 16th century to defend Venice. Sant'Andrea constitutes a prolongation of the island of Vignole, from which it is separated by a narrow channel, towards the Porto di San Nicolò on the Lido, between Venice's Island and the island of Sant'Erasmo.
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Each consists of a prolongation of the syncytial material of the proboscis skin, penetrated by canals and sheathed with a muscular coat. They seem to act as reservoirs into which the fluid which is used to keep the proboscis "erect" can withdraw when it is retracted, and from which the fluid can be driven out when it is wished to expand the proboscis.
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Nelson Parish is defined in the Territorial Division Act as being bounded: :Northwest by the Miramichi River and the Southwest Miramichi River; southwest by Blackville Parish; southeast by a line running parallel to the Kent County line and seven miles northwesterly therefrom; and northeast by the southwest line of lot number sixty-one, granted to Wm. Brown, and its southeasterly prolongation.
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For cementogenesis to begin, Hertwig epithelial root sheath (HERS) must fragment. HERS is a collar of epithelial cells derived from the apical prolongation of the enamel organ. Once the root sheath disintegrates, the newly formed surface of root dentin comes into contact with the undifferentiated cells of the dental sac (dental follicle). This then stimulates the activation of cementoblasts to begin cementogenesis.
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Citalopram and escitalopram: QT interval prolongation—new maximum daily dose restrictions (including in elderly patients), contraindications, and warnings. From Medicines and Healthcare products Regulatory Agency. Article date: December 2011 In overdose, fluoxetine has been reported to cause sinus tachycardia, myocardial infarction, junctional rhythms and trigeminy. Some authors have suggested electrocardiographic monitoring in patients with severe pre-existing cardiovascular disease who are taking SSRIs.
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Simonds Parish is defined in the Territorial Division Act as being bounded: :All that part of the County bounded south by the Bay of Fundy, west by The City of Saint John, north by the Kings County line, and east by the eastern line of lot number one, granted to Samuel Hugh, at Tynemouth Creek, and the northern prolongation thereof.
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The rhinophoral sheath is short with clusters of orange dots. There are three pairs of lateral appendages, with only the last pair forming a rounded, brown, and prominent globular structure. All lateral appendages are conical having a short but highly ramified prolongation at the apex. The first two lateral appendages are very short and the last pair is very elongate.
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A clinical test formerly used for evaluation of spinal stenosis is Queckenstedt's maneuver. Nowadays, a magnetic resonance imaging is used for identification of CSF flow obstruction. It often shows the prolongation of T1 and T2 signal in CSF caudal to a level of block. This phenomenon is named after Georges Froin (1874–1932), a French physician who first described it.
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The proposal for a referendum was first floated in May 2009. Beginning in late 2008, several supporters of President Tandja began a campaign to extend his term of office.Le Président Tandja reste muet sur les appels en faveur d’une prolongation de son mandat. APA 19 December 2008 Opposition from political opponents was swift, with dueling marches in Niamey in December 2008.
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Alma Parish is bounded on the south by the Bay of Fundy, on the west by the county line, on the north by a line running south seventy-two degrees west from the northwest angle of Hopewell Parish, and on the east a prolongation of the western line of lot number three, granted to James Speer, east of Owls Head.
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Desired particle size can be achieved by grinding, for instance through the use of an atomizer. Adolf Butenandt reported in 1932 that estrone benzoate in oil solution had a prolonged duration with injection in animals. No such prolongation of action occurred if it was given by intravenous injection. Estradiol benzoate was synthesized in 1933 and was marketed for use the same year.
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Northern Sermilik has two branches in the north with large glaciers at their heads. Elongated Tuttutooq Island is a prolongation of the southwestern end of the peninsula forming the southern shore of Northern Sermilik. The Narsaq Sound separates the peninsula from the island on the southern shore, connecting with neighbouring Tunulliarfik and Skovfjord.Prostar Sailing Directions 2005 Greenland and Iceland Enroute, p.
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Common side effects, occurring in more than 1% of users, include dizziness, headache, and weight gain. Side effects common to anticholinergics occur more often than with other TCAs such as imipramine. Cognitive side effects include delirium and confusion, as well as mood disturbances such as anxiety and agitation. Cardiovascular side effects may include orthostatic hypotension, sinus tachycardia, and QT-interval prolongation.
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In-flight Holter monitoring was not performed during these space flights. Thus, it is not known whether this prolongation was associated with any known arrhythmias. In-flight Holter monitoring was undertaken in the early Space Shuttle era. Virtually no changes in arrhythmias were documented in flights of 4 to 16 days during either intravehicular or extravehicular operations compared to preflight measurements.
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The Suor Uyata rises in the northwestern area of the Kolyma Lowland, only to the east of the eastern end of the Ulakhan-Sis Range. It is a smaller range than the latter, of which it can be considered an eastern prolongation. The main ridge stretches in a roughly WNW/ESE direction for about . Its highest summit is the high Salyr-Tas.
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Maximum pain relief is generally within an hour with effects up to 24 hours. Side effects may include respiratory depression (decreased breathing), sleepiness, adrenal insufficiency, QT prolongation, low blood pressure, allergic reactions,constipation, and opioid addiction. Among those with a history of seizures, there is a risk of further seizures. Opioid withdrawal following stopping buprenorphine is generally less severe than with other opioids.
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The usage of prokinetic agents such as metoclopramide, domperidone, and erythromycin are recommended for those who are septic and unable to tolerate enteral feeding. However, these agents may precipitate prolongation of the QT interval and consequently provoke a ventricular arrhythmia such as torsades de pointes. The usage of prokinetic agents should be reassessed daily and stopped if no longer indicated.
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His ambassador was a count named Asraka Ibn Umar Dawud, who sought renewed guarantees of friendship. The third embassy, led by a bishop of "Y.r.n.s." (perhaps Iruña) and Nuño González, was seeking the extension of a treaty whose terms were coming to an end for Castile. The final embassy of the day came from Fernando Ansúrez and sought the prolongation of peaceful relations.
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The central lobule is a small square lobule, situated in the anterior cerebellar notch. It overlaps the lingula, from which it is separated by the precentral fissure; laterally, it extends along the upper and anterior part of each hemisphere, where it forms a wing-like prolongation (ala), on each side, as the alae of the central lobule or alae lobuli centralis.
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Within this area, the coastal nation has sole exploitation rights over all natural resources. The "continental shelf" is the natural prolongation of the land territory to the continental margin's outer edge, or 200 nautical miles from the coastal state's baseline, whichever is greater. Here the coastal nation has the exclusive right to harvest minerals and also living resources "attached" to the seabed.
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Halofantrine can cause abdominal pain, diarrhoea, vomiting, rash, headache, itching and elevated liver enzymes. It can be associated with cardiotoxicity. The most dangerous side effect is cardiac arrhythmias: halofantrine causes significant QT prolongation, and this effect is seen even at standard doses. The drug should therefore not be given to patients with cardiac conduction defects and should not be combined with mefloquine.
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The plaintiff's case was that the defendant was negligent in not diagnosing Brain Stem Glioma and in the misdiagnosis of Rheumatic Chorea. Had a timely diagnosis been made, it was argued by the plaintiff, survival or prolongation of life would have been possible. Although the plaintiff listed several specialist doctors including Prof. Lamabadusuriya as witnesses, only Dr. Srilal Dias was called to give evidence.
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UNOMIG would not be extended beyond 31 January 1994, unless the Secretary-General reported that progress had been made or that the peace process will be served by the prolongation of its mandate. Finally, the Secretary-General was requested to take steps to enable the deployment of additional personnel within the originally authorised strength of UNOMIG if the situation on the ground allowed it.
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Serra de la Vall de la Torre, also known as Serra de la Vall,SBHAC 123a Brigada Mixta is a mountain range located at the southern end of the Catalan Pre-Coastal Range, Catalonia, Spain. The ridge's highest point is 450.8 m. This mountain range lies within the Benissanet and Corbera d'Ebre municipal term. It is a smaller and lower northern prolongation of the Serra de Cavalls.
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For example, transition may be defined as different from a subordinate theme (rondo form) or a developmental core.Caplin (2009). "Response to the Comments", p.54. . In sonata form, a retransition (the transition to the recapitulation) is the last part of the development section which prepares for the return of the first subject group in the tonic, most often through a grand prolongation of the dominant seventh.
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On the day of court's decision, there were suits against 17 other measures still pending. While Ministry of Health Protection Measures may be adopted indefinitely, Government Measures under Crisis Act may be adopted only for period of State of Emergency.Crisis Act No. 240/2000 Sb., Art. 5 Government may declare State of Emergency for period of 30 days, any prolongation requires assent of the Chamber of Deputies.
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Große Straße (Congress Hall in the background) The great road is almost long and wide. It was intended to be the central axis of the site and a parade road for the Wehrmacht. In its northwestern prolongation the road points towards Nuremberg Castle. This was to create a relation between the role of Nuremberg during the Third Reich and its role during medieval times.
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AZCERT focuses on drugs and drug–drug interactions, especially those that cause QT prolongation and Torsades de Pointes (TdP) arrhythmia, and provides its research and its lists of drugsQTdrugs.org free of charge to the public, healthcare providers, and researchers for personal, professional, and non-commercial purposes. To maintain the independence of its work, AZCERT does not receive funding from companies that have a commercial interest in medications.
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Class III Class III agents predominantly block the potassium channels, thereby prolonging repolarization. Since these agents do not affect the sodium channel, conduction velocity is not decreased. The prolongation of the action potential duration and refractory period, combined with the maintenance of normal conduction velocity, prevent re-entrant arrhythmias. (The re-entrant rhythm is less likely to interact with tissue that has become refractory).
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During this time the prolongation of the Paseo de la Castellana towards the North was projected. The proclamation of the Republic slowed down the building of new housing. The tertiary sector gave thrust to the economy. Illiteracy rates were down to below 20 %, and the city's cultural life grew notably during the so-called Silver Age of Spanish Culture; the sales of newspaper also increased.
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Schematic shows normal open and inactivated voltage-gated sodium channels on the left. Upon binding of poneratoxin, the sodium channel is forced to stay in the open state, unable to be inactivated. This leads to prolongation of action potentials, which is associated with the pain from bullet ant stings. Overall, poneratoxin disrupts normal function of voltage-gated sodium channels in both vertebrates and invertebrates.
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Potassium channel blockers exhibit reverse use- dependent prolongation of the action potential duration. Reverse use dependence is the effect where the efficacy of the drug is reduced after repeated use of the tissue. This contrasts with (ordinary) use dependence, where the efficacy of the drug is increased after repeated use of the tissue. Reverse use dependence is relevant for potassium channel blockers used as class III antiarrhythmics.
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Romano Ward syndrome (middle) and Jervell and Lange-Nielsen syndrome (bottom). Inherited, or congenital long QT syndrome, is caused by genetic abnormalities. LQTS can arise from variants in several genes, leading in some cases to quite different features. The common thread linking these variants is that they affect one or more ion currents leading to prolongation of the ventricular action potential, thus lengthening the QT interval.
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The historic paintings are visible in the walls of presbytery. The walls of main aisle, over arcades, were covered with the allegorical scenes, and on the vault, there are scenes from St. Martin's life. The equipment of interior of collegiate church comes from XVIII age. In the altar on the prolongation of right south nave there is the painting of Divine Mother with Jesus from XVI age.
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The Albera Massif () () is a mountain range located in the south of Pyrénées- Orientales and the north of Catalonia, between France and Spain. It is the main easternmost prolongation of the Pyrenees. Its highest peak is the Puig Neulós, with an elevation of 1,256 metres. Most of the southern side of the range is part of the Paratge Natural d'Interès Nacional de l'Albera natural reserve.
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Lakeview is located at and has an elevation of . According to the United States Census Bureau, the district has a total area of . of which is land and (0.0%) of which is water. Major north-south roads are Pontchartrain Boulevard, West End Boulevard, and Canal Boulevard - the last a prolongation of Canal Street; major east-west roads include Harrison Avenue and Robert E. Lee Boulevard.
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Yogurt was introduced to the United States in the first decade of the twentieth century, influenced by Élie Metchnikoff's The Prolongation of Life; Optimistic Studies (1908); it was available in tablet form for those with digestive intolerance and for home culturing. It was popularized by John Harvey Kellogg at the Battle Creek Sanitarium, where it was used both orally and in enemas,"Dr. John Harvey Kellogg." museumofquackery.
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In Japan, where the dominant religion is Shinto, 69% of the religious organisations agree with the act of voluntary passive euthanasia. The corresponding figure was 75% when the family asked for it. In Shinto, the prolongation of life using artificial means is a disgraceful act against life. Views on active euthanasia are mixed, with 25% Shinto and Buddhist organisations in Japan supporting voluntary active euthanasia.
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The mountain system as a whole is named after the city of Phetchabun which lies within the mountainous area. To the south and southeast lie the Dong Phaya Yen Mountains. Both sections of the Phetchabun massif are parallel and of a similar length, extending in a roughly north-south direction. The western range is a prolongation of the southern end of the Luang Prabang Range.
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Both blockages result in an increase of the QT interval and a prolongation of atrial and ventricular refractory periods. Azimilide blocks hERG channels (which encode the IKr current) with an affinity comparable to that with which KvLQT1 / minK channels (which encode the IKs current) are blocked. This block exhibits reverse use-dependence, i.e. the channel blocking effect wanes at faster pulsing rates of the cell.
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Safety of intravascular imaging, including intracoronary OCT and intravascular ultrasound, has been investigated by several studies. Recent clinical trials reported a very low rate of self- limiting, minor complications on over 3,000 patients where in all cases no harm or prolongation of hospital stay was observed. Intracoronary optical coherence tomography was demonstrated to be safe among heterogeneous groups of patients presenting varying clinical setting.
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The main ridge stretches in a roughly east/ west direction from the headwaters of the Khroma River to the Indigirka for about .Google Earth The highest peak is high. In the east, the Ulakhan-Sis, a prolongation of the range on the other side of the Indigirka River, stretches eastwards. To the west rises the Kyun-Tas and southwest of it the Selennyakh Range.
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Letter of Suleiman to Sigismund, winter 1533, expanding on the treaty signed in summer of the same year. Letter of Suleiman to Sigismund Augustus about the prolongation of the alliance, dated 6 March 1550. A Polish–Ottoman alliance, based on several treaties, occurred during the 16th century between the kingdom of Poland-Lithuania and the Ottoman Empire, as the Ottomans were expanding into Central Europe.
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Only one muscle is attached to the cuboid bone; the tibialis posterior. The tibialis posterior inserts to the under surface of the cuboid bone. While the flexor hallucis brevis arises, by a pointed tendinous process, from the medial part of the under surface of the cuboid bone, from the contiguous portion of the lateral cuneiform bone, and from the prolongation of the tendon of the tibialis posterior.
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View from outside the coach station. Avinguda de Catalunya (Catalan for Avenue of Catalonia) is a thoroughfare in the city of Lleida, Spain. On one end it is a prolongation of Rambla d'Aragó while on the other it meets Plaça d'Espanya and the river Segre. An extension into the Cappont neighbourhood, on the other side of the river, through the Pont de la Universitat, is underway.
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Petersville Parish is defined in the Territorial Division Act as being bounded: :Being all that part of the County southwest of a line beginning where the road from Jones’ millOlinville Road crosses the County line; thence northerly along the said road to the northwest line of lot number one, granted to John Short; thence northeasterly along the same to the northeast line of lot number five, granted to Sylvanus Haviland; thence northwesterly along the same and its northwestern prolongation to the southeast line of lands granted to James Corbett; thence northeasterly along the same to the southwest line of the grant to Henry Appleby; thence northwesterly along the same to the Gagetown Road;Lawfield Road, within CFB Gagetown thence northeasterly along the same to the northeast line of lot number twenty-five, granted to T.T. Hewlett, and thence northwesterly along the same and its northwestern prolongation to the Sunbury County line.
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There are disputes between China, Japan, and South Korea over the extent of their respective exclusive economic zones (EEZs) in the East China Sea. The dispute between the Peoples Republic of China (PRC) and Japan concerns the different application of the 1982 United Nations Convention on the Law of the Sea (UNCLOS), which both nations have ratified. China proposed the application of UNCLOS, considering the natural prolongation of its continental shelf, advocating that the EEZ extends as far as the Okinawa Trough. Its Ministry of Foreign Affairs has stated that "the natural prolongation of the continental shelf of China in the East China Sea extends to the Okinawa Trough and beyond 200 nautical miles from the baselines from which the breadth of the territorial sea of China is measured," which is applicable to the relevant UNCLOS provisions that support China's right to the natural shelf.
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The focus turned to non-imidazole H3R antagonists. They do not seem to interact with the CYP family on the same level as imidazole-based H3R antagonists and can reach the CNS more easily. Unfortunately other problems have come up such as strong binding to hERG K+ channel, phospholipidosis as well as problems with P-gp substrate. Strong binding to hERG K+ channel can lead to QT prolongation.
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Young larvae spins two to three leaves together, and mine these out completely. Older larvae live freely in the centre of a bundle of leaves of the tip of a shoot. The frass is deposited on the bottom of this enclosed space. Pupation takes place in a cocoon with a tube like prolongation that extends up to a circular opening, closed with silk, that will permit the escape of the imago.
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The decurrent striae are somewhat thin, regular, spaced, continuous, very attenuated at the top of the whorls, scarcely more marked at the base of the body whorl along the siphonal canal. The striations are strong, irregular, very wavy-flexuous. They form in the concave region of the whorls small corrugated folds, very close together. They blend in the body whorl, with the prolongation of the nodules of the keel.
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Because of potential for more severe side effects, this drug is on the list to avoid in the elderly. In 2015, the European Medicines Agency (EMA) announced a small but definite risk of QT prolongation associated with the use of hydroxyzine. This side effect is more likely to occur in people with pre-existing cardiac disease, or with the use of other medicines known to prolong the QT interval.
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They also had outlets to the sea. The central and western llanos, which politically were considered extensions of Caracas (except Barinas), had varying access to the central region. The Apure llanos were a prolongation of the central llanos. The western llanos, with the capital in Barinas, had been a province separate from Caracas, but they were in effect (the same as Apure) part of the same social, military, and political landscape.
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Common side effects include a slow heart rate, chest pain, low blood pressure, feeling tired, dizziness, shortness of breath, problems seeing, vomiting, and swelling. Other serious side effects may include QT prolongation, heart failure, or bronchospasm. Sotalol is a non-selective beta-adrenergic receptor blocker which has both class II and class III antiarrhythmic properties. Sotalol was first described in 1964 and came into medical use in 1974.
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The Dniester Hills border the Ciulucuri Hills to the north along the river Răut. The country's highest point, Bălăneşti Hill, which reaches , depending on the source, is situated in the Corneşti Hills, the western part of the Codri Plateau. Northwest of it are the Ciulucului Hills (average , max ). In the south, the Tigheci Hills (average , max ) are a prolongation, and run to the south parallel to the Lower Prut Valley.
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Harvey Parish is defined in the Territorial Division Act as being bounded: :North by a line running south seventy-two degrees west from the northwest angle of Hopewell Parish; west by the western line of lot number three, granted to James Speer, east of Owls Head, and its northerly prolongation to the northern line of the parish; east by Hopewell Parish, and south by Chignecto Bay, including Grindstone Island, so called.
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Olympias, a modern reconstruction of an ancient Athenian trireme. A ram was a weapon fitted to varied types of ships, dating back to antiquity. The weapon comprised an underwater prolongation of the bow of the ship to form an armoured beak, usually between six and 12 feet (2–4 m) in length. This would be driven into the hull of an enemy ship to puncture, sink or disable the ship.
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The Spanish Constitution of 1931 was the first legislated on the state capital, setting it explicitly in Madrid. During the 1930s, Madrid enjoyed "great vitality"; it was demographically young, but also young in the sense of its relation with the modernity. During this time the prolongation of the Paseo de la Castellana towards the North was projected. The proclamation of the Republic slowed down the building of new housing.
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In healthy volunteers, ketoconazole increased the Cmax and AUC concentrations of domperidone by 3- to 10-fold. This was accompanied by a QT interval prolongation of about 10–20 milliseconds when domperidone 10 mg four times daily and ketoconazole 200 mg twice daily were administered, whereas domperidone by itself at the dosage assessed produced no such effect. As such, domperidone with ketoconazole or other CYP3A4 inhibitors is a potentially dangerous combination.
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La Moleta or Moleta d'Alfara is a mountain of the Serra de l'Espina, a northern prolongation of the Ports de Tortosa-Beseit, Catalonia, Spain. It has an elevation of 812 metres above sea level.. La Moleta rises about 5 km NNW above the village of Alfara de Carles. It is readily identifiable from afar, for its striking squarish shape contrasts sharply with the other summits of the mountain chain.
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It consists of a telescopic "titanium rib" in curved form with several holes in a row for fixing in the desired length. A prolongation can be carried out after 6 months. The fixation takes place between two ribs or between a rib and the iliac crest. This results in an indirect erection of the deformed spine, resulting in an increase in the volume of the thoracic cavity along with the lung.
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Woodstock Parish is defined in the Territorial Division Act as being bounded: :South by the boundary of the County; east by the Saint John River; north by the lower line of lot number one, granted to Caleb Phillips, and its prolongation westerly; and west by the rear or western line of the second tier of lots west of the Saint John River to Eel River, including all the islands in front.
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Torsades de pointes, torsade de pointes or torsades des pointes (TdP) (, translated as "twisting of peaks") is a specific type of abnormal heart rhythm that can lead to sudden cardiac death. It is a polymorphic ventricular tachycardia that exhibits distinct characteristics on the electrocardiogram (ECG). It was described by French physician François Dessertenne in 1966. Prolongation of the QT interval can increase a person's risk of developing this abnormal heart rhythm.
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The Red Sea Gulf of the Aden split open during the Pliocene and early Pleistocene epochs. During these epochs, the Danakil Horst experienced an uplift of its southern prolongation. Analysis of plate tectonics at the triple junction region shows extension rates between 1 mm and 3 mm annually. Earthquake epicenters are focused along the peripheral block faults where the Ethiopian rift touches the Red Sea and Gulf of Aden.
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At the hinder part of the medial wall of the vestibule is the orifice of the vestibular aqueduct, which extends to the posterior surface of the petrous portion of the temporal bone. It transmits a small vein, and contains a tubular prolongation of the membranous labyrinth, the ductus endolymphaticus, which ends in a cul-de-sac, the endolymphatic sac, between the layers of the dura mater within the cranial cavity.
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The Battle of Bryn Glas, (sometimes referred to in English accounts as the Battle of Pilleth, although Bryn Glas translates as blue hill) was fought on 22 June 1402, near the towns of Knighton and Presteigne in Powys. It was a great victory for the Welsh under Owain Glyndŵr, and it resulted in the prolongation of the Welsh war of independence and the destabilisation of English politics for several years afterward.
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In fact, they are encountered, though less commonly, after the use of chloroquine and metronidazole as well. Toxic effects on the myocardium have been described even in doses generally considered safe. These are rise in pulse rate, fall in systolic blood pressure and ST-T changes in the electrocardiogram. The other rare E.C.G. changes include deformity of QRS complexes, prolongation of PR interval, atrial premature beats, and atrial tachycardia.
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A resources sharing joint development area arrangement instead had to be agreed to. Further details on this in the following section. The 1997 treaty saw Australia's natural prolongation argument prevail as far as the seabed (essentially the continental shelf) claim is concerned. However, Indonesia's median line argument was accepted for establishing its rights over the water column or exclusive economic zone, resulting in the separation of the two types of boundaries.
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This procedure is directly reversed in the Friska. Although the principal key of the Friska is F-sharp major, Liszt chooses to begin in the tonic minor key, F-sharp minor, which is sustained until bar 51. For practical reasons of notation (i.e., the prolongation of the tonic minor key), Liszt chooses the key signature of F-sharp minor, until the arrival of the main theme in F-sharp major.
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Typical delays are in the 50 millisecond to 200 millisecond range. In stutterers, DAF may produce slow, prolonged but fluent speech. In the 1960s to 1980s, DAF was mainly used to train prolongation and fluency. As the stutterer masters fluent speech skills at a slow speaking rate, the delay is reduced in stages, gradually increasing speaking rate, until the person can speak fluently at a normal speaking rate.
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A nitrite ester In organic chemistry, nitrites are esters of nitrous acid and contain the nitrosoxy functional group. Nitro compounds contain the C–NO2 group. Nitrites have the general formula RONO, where R is an aryl or alkyl group. Amyl nitrite and other alkyl nitrites are used in medicine for the treatment of heart diseases, and occasionally used recreationally for their "rush" and prolongation of orgasm, particularly in males.
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The Kular Range extends in an arch north of Batagay-Alyta to the NE for about , west and NW of the Bytantay River and west of the Yana, after it joins that great river. In the northeast rise the Kyundyulyun mountains, a prolongation beyond the Yana River. The highest point of the Kular Range is an unnamed high summit. It is one of the main subranges of the Verkhoyansk Range system.
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Although preferentially cytosolic, SIRT2 transiently shuttles to the nucleus during the G2/M transition of the cell cycle, where it has a strong preference for histone H4 lysine 16 (H4K16ac), thereby regulating chromosomal condensation during mitosis. During the cell cycle, SIRT2 associates with several mitotic structures including the centrosome, mitotic spindle, and midbody, presumably to ensure normal cell division. Finally, cells with SIRT2 overexpression exhibit marked prolongation of the cell cycle.
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McAdam Parish is defined in the Territorial Division Act as being bounded: :East by Dumfries and Prince William Parishes; southeast by Manners Sutton Parish; south and southwest by the County line and the International Boundary; northwest by the southwesterly prolongation of a line running southwesterly and parallel to the upper line of Prince William Parish from the southwest angle of lot number six, granted to John Benn below Shogomoc Stream.
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The carapace (hard upper shell) is punctuated and slender, with a width of 0.5 to 0.6 mm and a depth of 0.5 to 0.6 mm. The cephalon (the head) has a few tubercles ventrally. The branchiostegites are uninflated, with a few tubercles along the ventral cervical groove. The rostrum (spinelike anterior median prolongation of the carapace) is slender and triangular, with a length of 1.0 to 1.6 mm.
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The risk of arrhythmias is higher for those with Jervell and Lange-Nielsen syndrome than other forms of long QT syndrome. Although this risk is dependent on the underlying genetic defect and degree of QT prolongation, without treatment more than 50% of those affected will die before the age of 15. However, treatment with beta blockers markedly reduces the risk of death, as does, in selected cases, implantation of a defibrillator.
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Eldon Parish is defined in the Territorial Division Act as being bounded: :Northerly by the Province of Quebec Boundary line, easterly by a line beginning on the southern bank or shore of Restigouche River at the northwest angle of lot number twenty-two, granted to George Firth below Metapedia, thence southerly along the western line of said lot and its prolongation to the northeast angle of lot number one, in Dawsonville, thence continuing southerly along the eastern line of said lot number one and its southern prolongation, to the southeast angle of lot number two (Thomas Gracie) and thence true south to the County limits; southerly by the County line and westerly by a straight line extending from the Province of Quebec Boundary line in the Restigouche River, at the mouth of Upper Thorn Point Brook to Whites Brook railway station on the Canadian National Railways, and thence prolonged southerly to the Victoria County Boundary line.
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The early 20th-century music theorist Heinrich Schenker (1868–1935) was responsible for developing both the conceptual framework for prolongation and a means of analyzing music in terms of prolonged musical structures (called Schenkerian analysis). Schenker’s own usage of the term differs from the modern one. The German word Prolongation is not common, and Schenker first used it in a very specific meaning (maybe originating in legal, possibly Viennese vocabulary), referring to the extension of the primal laws (Urgesetze) or of the primal concepts (Urbegriffe) of strict composition in free compositionFor instance when he explained that the task of the study of counterpoint is to reveal how its fundamental laws can be extended to apply to free composition: "But to reveal the basic form together with its variants, and [thereby] to uncover only prolongations of a fundamental law even where apparent contradictions hold sway – this alone is the task of counterpoint!" Kontrapunkt I (1910), p.
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Cardwell Parish is defined in the Territorial Division Act as being bounded: :West by Sussex Parish and the east line of lot number twenty- five, granted to Jacob Snider, on the northern side of the Kennebecasis River, above Smith's Creek; north by a line running from the northeast angle of said lot north sixty-six degrees east to the County line; east by the County line, and south by a line commencing at the northwestern angle of lot number seven, granted to Simon Armstrong; thence east following the northern side line of the said grant and its prolongation easterly until it reaches the northeastern angle of lot number eighteen, granted to David Law; thence in a direct line to the northwestern angle of lot number eight, granted to Thomas Nicholson, in Lake block;Part of Mechanics Settlement. thence along the northern line of said lot number eight and its eastern prolongation to the County line.
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There is very little formal, modern published information on the pharmacological actions of cerberin. One primary source reports that its ingestion results in electrocardiogram (ECG) changes, such as various types of bradycardia (e.g., sinus bradycardia), AV dissociation, and junctional rhythms; second-degree sinoatrial block and nodal rhythm are also described. In the case of digitalis administration, ST depression or T wave inversion may occur without indicating toxicity; however, PR interval prolongation indicate toxicity.
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Tswapong Hills A jumble of hematite and granite blocks and kopjes forms the Lepokole Hills, a western prolongation of the Matobo Hills in Zimbabwe. They are located 15 km north of Bobonong. The last of the San in eastern Botswana lived in the hills and left more of their rock paintings in the caves and rocks. Stone Age tools and ancient pottery scattered around the hills are evidence of even earlier occupation.
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Not long afterward, he published a paper on the lag phase of E. coli, which is also influenced by X-irradiation.Beutler E et al. Prolongation of the lag phase of irradiated Escherichia coli. Proc Soc Exp Biol Med 85: 682–685, 1954 This work, carried out during his residency in the laboratory of Leon O. Jacobson, was aimed at the development of an assay for a humoral radioprotective factor, and reflected a chance observation.
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Surgery is the primary method of treatment for most isolated, solid cancers and may play a role in palliation and prolongation of survival. It is typically an important part of definitive diagnosis and staging of tumors, as biopsies are usually required. In localized cancer, surgery typically attempts to remove the entire mass along with, in certain cases, the lymph nodes in the area. For some types of cancer this is sufficient to eliminate the cancer.
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There was a significant reduction in the rate of cardiovascular death, but not in the rate of death from any cause. Later post- hoc analysis of the ATHENA-results showed a significant reduction in the rate of stroke. Patients randomized to dronedarone were more likely to develop bradycardia and QT-interval prolongation (but only 1 case of Torsades). Nausea, diarrhea, rash, and creatinine elevation also were more common in the dronedarone arm.
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The university board (consistory) gave Åkesson their vote of confidence and she remained, while the three vice-rectors left their positions. A year later, Åkesson commented on the leadership crisis, saying that she could have prepared herself better for her position as Rector. Åkesson's appointment as Rector in Uppsala will end at the end of 2020, and she has declared that she will not be a candidate for a prolongation of her mandate.
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The two craters are not on the same axis, contrary to those Puy de Côme. The Puy de Pariou is often compared to Mount Vesuvius, because of its recent cone topping a somma. The ancient crater, “old Pariou” and its prolongation by the tuff ring are still visible from the west and the north. It is hidden under the new crater, “new Pariou” at the south and under old lava flows at the east.
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The internal surface forms part of the bony wall of the lesser pelvis. In front it is limited by the posterior margin of the obturator foramen. Below, it is bounded by a sharp ridge that provides attachment to a falciform prolongation of the sacrotuberous ligament, and, more anteriorly, gives origin to the transverse perineal and ischiocavernosus muscles. Posteriorly the ramus forms a large swelling, the tuberosity of the ischium, where the hamstrings originate.
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Shell is elliptical, solid, upper side convex and lower side flat. The reproductive system is diagnostic feature: Geomalacus anguiformis has atrial diverticulum shorter than spermatheca duct while Kerry slug Geomalacus maculosus has atrial diverticulum longer than spermatheca duct. Geomalacus anguiformis has penis long, vas deferens very thin, spermatheca oval with long duct. Geomalacus anguiformis differs from Geomalacus oliveirae in its atriopenis inserting at the prolongation of the atrial long axis (not laterally).
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This molecule was subsequently named duloxetine. In 2001, Lilly filed a New Drug Application (NDA) for duloxetine with the US Food and Drug Administration. In 2003, however, the FDA "recommended this application as not approvable from the manufacturing and control standpoint" because of "significant cGMP (current Good Manufacturing Practice) violations at the finished product manufacturing facility" of Eli Lilly in Indianapolis. Additionally, "potential liver toxicity" and QTc interval prolongation appeared as a concern.
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Lasiognathus waltoni is a species of wolftrap angler known from the eastern central Pacific Ocean. This species is found at depths to around . The females of this species grow to a length of SL. This species is characterized by a membranous anterior crest on its escal bulb, and an elongated, cylindrical distal escal appendage without a prolongation at the tip. Its species name honors Sir Isaac Walton, author of The Compleat Angler.
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Despite measures taken by new Minister of Foreign Affairs, the scandal in the first round repeated in the second one, but in higher proportions. Kilometer-long queues were reported in several European cities, including Paris, Strasbourg, London, Dublin, Brussels, Oslo, Bonn, Munich, Stuttgart, Turin, Rome and Madrid. Once more, ACL and Monica Macovei urged the prolongation of voting process. Spontaneous protests broke out again in front of embassies and consulates in major European cities.
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This difference with the column capitals disappeared with Roman times, when anta or pilaster capitals have designs very similar to those of the column capitals.The Classical Language of Architecture by John Summerson, p.47 "Anta" entry The Ionic anta capitals as can be seen in the Ionic order temple of the Erechtheion (circa 410 BCE), are characteristically rectangular Ionic anta capitals, with extensive bands of floral patterns in prolongation of adjoining friezes.
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At a cellular level, vanoxerine acts to block cardiac ion channels. Vanoxerine is a multichannel blocker, acting on IKr (potassium), L-type calcium and sodium ion channels. By blocking these specific channels, there is a prolongation of the action potential of the cell, preventing reactivation by a reentrant circuit. The block is strongly frequency dependant: as the pacing of the heart increases so does the frequency of ion channel blocking by vanoxerine.
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As they pass across the subcutaneous inguinal ring, they are connected together by delicate fibrous tissue, forming a fascia, called the intercrural fascia. This intercrural fascia is continued down as a tubular prolongation around the spermatic cord and testis, and encloses them in a sheath; hence it is also called the external spermatic fascia. The subcutaneous inguinal ring is seen as a distinct aperture only after the intercrural fascia has been removed.
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Early Quranic Arabic lacked precision because distinguishing between consonants was impossible due to the absence of diacritical marks (a'jam). Vowelling marks (tashkil) to indicate prolongation or vowels were absent as well. Due to this there were endless possibilities for the mispronunciation of the word. The Arabic script as we know it today, the scripta plena, which has pointed texts and is fully vowelled was not perfected until the middle of the 9th century.
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In a Phase II study on 119 patients with advanced ovarian cancer in which the standard therapies had already been ineffective, treatment with abagovomab led to a prolongation of survival time (23.4 months compared to 4.9 months) in those patients who responded to the vaccination, i.e. those in whom the formation of antibodies against the tumour was proven (almost 70% of patients). The vaccine showed hardly any side effects in preliminary studies.
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Fred Lange-Nielsen (28 September 1919 – 28 December 1989) was a Norwegian doctor and jazz musician (bass, vocals), known in the early Oslo environments, and from several recordings. Lange-Nielsen and Anton Jervell were the first to describe Jervell and Lange-Nielsen syndrome (JLNS) in 1953.Jervell A, Lange- Nielsen F. Congenital deaf-mutism, functional heart disease with prolongation of the QT interval and sudden death. American Heart Journal, 1957; 54: 59 - 68.
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Measurement of the QT interval with normal and prolonged QT intervals left Diagnosing long QT syndrome is challenging. Whilst the hallmark of LQTS is prolongation of the QT interval, the QT interval is highly variable among both those who are healthy and those who have LQTS. This leads to overlap between the QT intervals of those with and without LQTS. 2.5% of those with genetically proven LQTS have a QT interval within the normal range.
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This mountain range is a part of the wider Tenasserim Hills system. It forms the southernmost section of the Indo- Malayan cordillera which runs from Tibet through the Kra Isthmus into the Malay Peninsula.Avijit Gupta, The Physical Geography of Southeast Asia, Oxford University Press, 2005. The Titiwangsa mountain range begins in the north as the Sankalakhiri Range, a prolongation of the Nakhon Si Thammarat Range which includes the smaller Pattani, Taluban, and Songkhla sub-ranges.
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This mountain range is located at the eastern end of the Iberian System and the Sierra de Nogueruelas is its easternmost prolongation. The Sierra Mayabona is another subrange of the Sierra de Gúdar. Its summits are usually covered in snow in the winter and the 1710 m high Cabezo de las Cruces is one of the highest peaks of the Land of Valencia. Mora de Rubielos is the most important town in this mountainous zone.
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Oil solutions are solutions of a compound with oil, for instance sesame oil or castor oil. When free steroids like estradiol are administered in oil solution by intramuscular injection, they are rapidly absorbed and the duration is relatively short. A single 1 to 2 mg dose of estradiol in oil solution by intramuscular injection has a duration of about 1 or 2 days. Little prolongation of duration is achieved with the use of larger doses.
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The plaintiff's leg had been broken in a collision, and he was discharged from hospital after the bone had clinically sufficiently knitted. Shortly thereafter, however, his crutches slipped on a smooth floor and the bone broke again. The court found that the fall had been caused by the plaintiff' own carelessness, and that the defendant was not liable for the prolongation of the recovery. The court also disallowed costs for the doctor's qualifying expenses.
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Dr. Cyril Wecht was hired by Callenders and Co., a Bahamian law firm, to do an independent autopsy. Wecht stated Daniel Smith died as a result of the interaction of methadone, an analgesic, and the antidepressants Zoloft and Lexapro. The metabolism and the breakdown of the methadone is delayed in the presence of Zoloft, according to Wecht. Methadone can alter the cardiac rhythm – it’s referred to as a prolongation of the QT interval.
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It is dorsally flattened and punctuated along the inner margins of the lateral carinae (narrow, longitudinal ridge extending along each side of carapace) and is smooth medially and bristly distally near the acumen (spine-like anterior median prolongation of the carapace). The lateral carinae are moderately developed, commencing at the base of the rostrum, terminating at the acumen, without tubercles or spines. The ventrolateral margins are bristly. The acumen is blunt and upturned.
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The HEP was involved in peace negotiations with the PKK. On 16 April 1993 chairman Ahmet Türk and five other MPs traveled to the Bar Elias in Lebanon, demanding a prolongation of the cease fire declared by the PKK before. The cease-fire was prolonged at a press conference given the same day. Due to the overt promotion of Kurdish cultural and political rights the party was banned by the Constitutional Court in July 1993.
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Head morphology of Muscid fly. In entomology, the term labellum has been applied variously and in partly contradictory ways. One usage is in referring to a prolongation of the labrum that covers the base of the rostrum in certain Coleoptera and Hemiptera. In contrast, the commonest current use of the term is in the anatomy of the mouthparts of Diptera, particularly those in which the labium forms the bulk of the proboscis, such as in the housefly family.
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Traxoprodil (developmental code name CP-101606) is a drug developed by Pfizer which acts as an NMDA antagonist, selective for the NR2B subunit. It has neuroprotective, analgesic, and anti-Parkinsonian effects in animal studies. Traxoprodil has been researched in humans as a potential treatment to lessen the damage to the brain after stroke, but results from clinical trials showed only modest benefit. The drug was found to cause EKG abnormalities (QT prolongation) and its clinical development was stopped.
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Some inhibitors are time dependent. In other words, it takes time for the antibody to react with and inactivate the added clotting factor. The clotting test performed immediately after the specimens are mixed may show correction because the antibody has not had time to inactivate its target factor. A test performed after the mixture is incubated for 1 to 2 hours at 37°C will show significant prolongation over the clotting time obtained after immediate mixing.
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Those fibers which arise from the ramus of the pubis are short, horizontal in direction, and are inserted into the rough line of the femur leading from the greater trochanter to the linea aspera, medial to the gluteus maximus. Those fibers from the ramus of the ischium are directed downward and laterally with different degrees of obliquity, to be inserted, by means of a broad aponeurosis, into the linea aspera and the upper part of its medial prolongation below.
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Medications should be avoided that further prolong the QT interval such as sotalol and amiodarone as these drugs can promote abnormal heart rhythms. Lists of medications associated with prolongation of the QT interval can be found online. Drugs which reduce blood levels of potassium such as diuretics like furosemide and bendroflumethiazide should also be avoided as these can worsen the tendency to periodic paralysis and arrhythmias. Conversely, potassium-containing supplements to increase blood potassium levels may be helpful.
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Hillsborough Parish is defined in the Territorial Division Act as being bounded: :South and west by the south line of lot numbered seventeen, granted to William Carlisle and its prolongation westerly to the distance of twelve miles from The Petitcodiac River; thence by a line running north twenty degrees west by the magnet of the year one thousand seven hundred and sixty- five to Coverdale Parish; north by Coverdale Parish; and east by the Petitcodiac River.
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Abnormalities in conduction and repolarization of the heart that can result from anorexia nervosa include QT prolongation, increased QT dispersion, conduction delays, and junctional escape rhythms. Electrolyte abnormalities, particularly hypokalemia and hypomagnesemia, can cause anomalies in the electrical activity of the heart, and result in life-threatening arrhythmias. Hypokalemia most commonly results in anorexic patients when restricting is accompanied by purging (induced vomiting or laxative use). Hypotension (low blood pressure) is common, and symptoms include fatigue and weakness.
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With mild to moderate hyperkalemia, there is prolongation of the PR interval and development of peaked T waves. Severe hyperkalemia results in a widening of the QRS complex, and the ECG complex can evolve to a sinusoidal shape. There appears to be a direct effect of elevated potassium on some of the potassium channels that increases their activity and speeds membrane repolarisation. Also, (as noted above), hyperkalemia causes an overall membrane depolarization that inactivates many sodium channels.
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At the close of the Variscan orogeny, Iberia was still connected to northwestern France (the Armorican Massif) and most likely was a northwestern prolongation of Aquitania. Its later movements were vital to the alpine cycle of the Pyrenean orogeny. This is accepted by most geologists, yet the details of Iberia's movements are still uncertain. During the Upper Jurassic, a rift was propagating from the spreading Central Atlantic along the continental margin of northwestern France towards Aquitaine.
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Lasiognathus saccostoma is a species of wolftrap angler known from the eastern central Pacific Ocean and tropical waters of the Atlantic Ocean. It is found at depths to . The females of this species grow to a length of SL. This species has a slender, compressed prolongation at the tip of its elongated, cylindrical distal escal appendage, with numerous lateral serrations and distal filaments. Unlike in L. amphirhamphus, there are three escal hooks and they are darkly pigmented.
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"Doctor Robert Isaac COWIE", North Isles Family History Cowie was an enthusiastic lover of his native islands, one proof of which was his selection of certain physical peculiarities of the Shetland people as the subject of his thesis when applying for the degree of M.D. At a later period he contributed to the International Congress at Paris an article on health and longevity, bringing out a prolongation of life beyond the average among the Shetlanders, which excited considerable notice.
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This conception of "prolongation" may have its origin in the teaching of Hans Weisse. In his analysis of J.S. Bach's Little Prelude in D minor, BWV 926, in Der Tonwille 5, Schenker proposes what may be his earliest figure showing the steps through which the Ursatz develops into the foreground. He explains that this figure "shows the gradual growth of the voice-leading prolongations, all predetermined in the womb of the Urlinie".Der Tonwille 5 (1923), p. 8, Fig.
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Medial to the opening for the carotid canal and close to its posterior border, in front of the jugular fossa, is a triangular depression; at the apex of this is a small opening, the aquaeductus cochleae (or cochlear aqueduct, or aqueduct of cochlea), which lodges a tubular prolongation of the dura mater establishing a communication between the perilymphatic space and the subarachnoid space, and transmits a vein from the cochlea to join the internal jugular vein.
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The 1976–1977 first season brings the 9th title and a new golden boot for Dudu Georgescu (47 goals). In the autumn of '77 in the CCE, Dinamo wins a thrilling game against Atlético Madrid 2–1, but loses at Madrid, 2–0. In the second round of the UEFA Cup (after eliminating Alki Larnaca from Cyprus) Dinamo is eliminated by Eintracht Frankfurt, team of Pezzey, Grabowsky and Holzenbein (2–0 and 0–3 in prolongation).
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The caudal fin is cream with a dark brown band in the distal half and with a narrow midlateral prolongation. The barbels and pectoral spines are cream or light brown, with dark-brown spots, only present sometimes on the dorsal surfaces in B. cessator and B. insignis. Sexual dimorphism is exhibited by B. insignis. Males have the anus situated immediately in front of a genital papilla, which is located immediately posterior to the pelvic-fin base.
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Ventricular tachycardia, which describes a heart rate of over 100 beats per minute with at least three irregular heartbeats as a sequence of consecutive premature beats, can degenerate into ventricular fibrillation, which is rapidly fatal without cardiopulmonary resuscitation (CPR) and defibrillation. Long QT syndrome can cause syncope when it sets off ventricular tachycardia or torsades de pointes. The degree of QT prolongation determines the risk of syncope. Brugada syndrome also commonly presents with syncope secondary to arrhythmia.
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This is because dopamine plays a primary role in regulating prolactin release by binding to D2 receptors on prolactin-secreting cells in the anterior pituitary. Thus, when tiapride blocks these receptors these cells are disinhibited and release more prolactin. The side-effect reported most commonly to the U.S. Food and Drug Administration (FDA) is rhabdomyolysis, a condition characterized by muscle tissue breakdown. Cardiac abnormalities such as prolongation of the QT interval and torsades de pointes have also been observed.
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While the mass was originally scored for choir, strings and organ, later versions include with trumpets and timpani, and clarinets. The mass was also used in Salzburg where the textual compression was deemed "unacceptable", therefore the composer's brother Michael Haydn expanded the Gloria, from 31 measures to 118. Very few performances however, use this expansion. However, the Oxford edition presents Michael Haydn's prolongation in the main body of the text and Joseph's short original as an appendix.p.
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LQT5 is caused by variants in the KCNE1 gene responsible for the potassium channel beta subunit MinK. This subunit, in conjunction with the alpha subunit encoded by KCNQ1, is responsible for the potassium current IKs which is decreased in LQTS. LQT6 is caused by variants in the KCNE2 gene responsible for the potassium channel beta subunit MiRP1 which generates the potassium current IKr. Variants that decrease this current have been associated with prolongation of the QT interval.
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The revolutionaries were split on how to deal with Porfirio Díaz and Vice President Ramón Corral. Madero favored having Díaz and Corral resign, with Francisco León de la Barra serving as interim president until a new election could be held. Carranza disagreed with Madero, arguing that allowing Díaz and Corral to resign would legitimate their rule, while an interim government would merely be a prolongation of the dictatorship and would discredit the Revolution. Madero's view prevailed, however.
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Mobitz I is characterized by a progressive, yet, reversible block of the AV node. On ECG, this is defined by a progressive prolongation of the PR interval, with a resulting dropped beat (the PR interval gets longer and longer until a beat is finally dropped, or skipped). Some patients are asymptomatic; those who have symptoms respond to treatment effectively. There is low risk of a Mobitz I AV block leading to heart attack and complete heart block.
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There is now good evidence that treatment with hematopoietic growth factors—including granulocyte colony-stimulating factor (G-CSF), which is used to treat AML, and granulocyte-macrophage colony-stimulating factor—can cause SS. Lesions typically occur when the patient has leukocytosis and neutrophilia but not when the patient is neutropenic. However, G-CSF may cause SS in neutropenic patients because of the induction of stem cell proliferation, the differentiation of neutrophils, and the prolongation of neutrophil survival.
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ABT-239 is an H3-receptor inverse agonist developed by Abbott. It has stimulant and nootropic effects, and has been investigated as a treatment for ADHD, Alzheimer's disease, and schizophrenia. ABT-239 is more active at the human H3 receptor than comparable agents such as thioperamide, ciproxifan, and cipralisant. It was ultimately dropped from human trials after showing the dangerous cardiac side effect of QT prolongation, but is still widely used in animal research into H3 antagonists / inverse agonists.
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The goals of treatment for people with chronic heart failure are the prolongation of life, prevention of acute decompensation, and reduction of symptoms, allowing for greater activity. Heart failure can result from a variety of conditions. In considering therapeutic options, excluding reversible causes is of primary importance, including thyroid disease, anemia, chronic tachycardia, alcohol abuse, hypertension, and dysfunction of one or more heart valves. Treatment of the underlying cause is usually the first approach to treating heart failure.
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A proposal was also adopted to guarantee a right to the Internet for all,Loi numérique: "L'accès à Internet aussi indispensable que l'accès à l'eau ou l'électricité" sur RMC, 19 janvier 2016 even if limited, allowing access to electronic mail or online public services. Network operators will be encouraged to develop their investments where the needs are greatest, through the prolongation and extension of the scope of over-damping to the deployment of fibre in rural areas.
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Saint Patrick Parish is defined in the Territorial Division Act as being bounded: :West and northwest by Saint Andrews Parish and Saint Croix Parish; east by the west line of the grant to Philip Bailey and others, and its northerly prolongation; north by a line commencing at the most southern angle of lot number five, granted to John Gilman, on the southwestern side of Digdeguash River; thence northeasterly along the southeasterly line of said lot to the Digdeguash River; thence down stream along the same to the lower line of the lot granted to John Campbell; thence along the same easterly to the rear thereof; thence northerly along the rear of the said last mentioned lot to meet the westerly prolongation of the line dividing the lots ten and eleven in the Clarence Hill grant plan, and thence easterly along the said line dividing the lots number ten and number eleven to the eastern boundary of the parish; and south by Passamaquoddy bay, including all the islands west of the east line of the said parish within two miles of the shore.
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This mountain range is located at the eastern end of the Iberian System and is a southern prolongation of the Sierra de Javalambre. Its highest point is Puntal del Agrillar (1,616 m). Other important peaks are Puntal de Magaña (1,614 metres), Alto del Tomatero (1,607 metres), Puntal de Peiró (1,605 metres) and Salada (1,581 metres), where there is a military communications compound. Its summits are usually covered in snow in the winter and are among the highest peaks of the Land of Valencia.
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Lake Como: Renzo and Lucia are two farmers who are in love. But the cruel and despotic Don Rodrigo impairs their marriage because he is secretly in love with Lucia. The two have to flee from their Lombard village, and shelter by different routes: Renzo goes to Milan and Lucia in a convent in Monza. Even the plague of 1600 contributes to the prolongation of the separation of the two lovers, who eventually find themselves in a hospital in Milan.
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Also, the patient's history should be checked, especially with regard to anticoagulant use or liver disease. Provided that the abnormal result is reproduced on a fresh specimen and there is no obvious explanation from the history, a mixing study should be performed. If the mixing study shows correction and no prolongation with incubation, factor deficiency should be looked for, starting with VIII and IX. Vitamin K-dependent and nonvitamin K–dependent factors should be considered to rule out accidental or surreptitious warfarin ingestion.
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When two copies of the variant are inherited (homozygous, autosomal recessive inheritance) the more severe Jervell and Lange-Nielsen syndrome is found, associated with more marked QT prolongation, congenital sensorineural deafness, and a greater risk of arrhythmias. LQT1 is associated with a high risk of faints but lower risk of sudden death than LQT2. LQT1 may also affect glucose regulation. After ingesting glucose, those with LQT1 produce more insulin than would be expected, which is followed by a period of insulin resistance.
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The femoral sheath (crural sheath) is formed by a prolongation downward, behind the inguinal ligament, of the abdominal fascia, the transverse fascia being continued down in front of the femoral vessels and the iliac fascia behind them. The femoral sheath is contained within the femoral triangle. The sheath assumes the form of a short funnel, the wide end of which is directed upward, while the lower, narrow end fuses with the fascial investment of the vessels, about 4 cm. below the inguinal ligament.
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Nifedipine has been used frequently as a tocolytic (agent that delays premature labor). A Cochrane review has concluded that it has benefits over placebo or no treatment for prolongation of pregnancy. It also has benefits over beta-agonists and may also have some benefits over atosiban and magnesium sulfate, although atosiban results in fewer maternal adverse effects. No difference was found in the rate of deaths among babies around the time of birth, while data on longer-term outcomes is lacking.
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Serra Calderona (; ), often referred to as La CalderonaVicenç M. Rosselló i Verger, Toponímia, geografia i cartografia is a long mountain range in the Camp de Túria, Horta Nord and Alt Palància comarcas of the Valencian Community, between the provinces of Castelló and Valencia Spain. This moderately high range is an eastern prolongation of the Sierra de Javalambre. Its highest point is El Gorgo (907 m). Other important summits are Muntanya del Garbí (600 m) and El Puntal de l' Abella (635 m).
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Saint George Parish is defined in the Territorial Division Act as being bounded: :West by Saint Patrick Parish, Dumbarton Parish and Passamaquoddy Bay; north by the County line; east by the rear line of lot number three, granted to William Payne and its prolongation northerly to the County line, and southerly to Letang River; south by the Bay of Fundy, the channel to and through Letete Passage, and the channel to and through Letang Harbour and River, including Bliss Island.
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Saint Stephen Parish was established in 1786 as one of the province's original parishes, Available as a free download from Google Books. with boundaries that included all of modern Dufferin Parish but only ran as far north as Mayfield and Barter Settlement. In 1813 the parish was expanded northward as far as the prolongation of the northern line of Saint David, the boundary now running through King Lake and striking the St. Croix River. Available as a free download from Canadiana.
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Malik Ayaz foreseeing the ruin of his forces in the prolongation of the struggle made peace and fell back on Khiljipur, and eventually retreated to Gujarat.The Hindupat, the Last Great Leader of the Rajput Race. 1918. Reprint. London pg 84-86The Sultan is said to have received Malik Ayaz coldly when the latter waited on him at Chapaneri. The Mirati Sikandari says that not only was the Sultan very cold to Ayaz, but that all the people of Gujarat called him a coward.
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Supporters of Tandja to the slogan of his 2004 re-election campaign, "Tazarché", which means "Continuation" or "Continuity" in Hausa: supporters were quickly dubbed "Tazarchistes" and opponents "Anti- Tazarchistes".Des Nigériens manifestent pour la mise en place d’une transition politique de trois ans dans leur pays. APA 21 December 2008Demande de prolongation de trois ans du mandat du président Tandja. AFP 21 December 2008 Demonstrations were held throughout Niger, while political committees were created, headed by supporters of Tandja outside government.
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The presence of these kind of vestigial structures is known as an atavism. When a human embryo develops a true tail, it is located as a prolongation of the coccyx, just like the tail of a dog or a monkey. Oram's tail emerges from his lumbar region, which is a clear sign that it is caused by split spine. The tail consists of a 33 cm (13 inches) long and 25 mm (1 inch) thick appendix to the bone of the spine.
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Historically, amnioinfusion has been used when MSAF was present, which involves a transcervical infusion of fluid during labour. The idea was to dilute the thick meconium to reduce its potential pathophysiology and reduce cases of MAS, since MAS is more prevalent in cases of thick meconium. However, there are associated risks, such as umbilical cord prolapse and prolongation of labour. The UK National Institute of Health and Clinical Excellence (NICE) Guidelines recommend against the use of amnioinfusion in women with MSAF.
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Nang Rong Waterfall, a natural attraction in Nakhon Nayok The northern part of the province is in the Sankamphaeng Range, the southern prolongation of the Dong Phaya Yen mountains, with the highest elevation the 1,292 meter high Yod Khao Kiew. Most of that area is covered by the Khao Yai National Park. The central part of the province however is a rather flat river plain formed by the Nakhon Nayok River. The southern part of the province has relatively infertile acidic soil.
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Jervell and Lange–Nielsen syndrome (JLNS) is a rare form of LQTS inherited in an autosomal recessive manner. In addition to severe prolongation of the QT interval, those affected are born with severe sensorineural deafness affecting both ears. The syndrome is caused by inheriting two copies of certain variant in the KCNE1 or KCNQ1 genes. The same genetic variants lead to the LQT1 and LQT5 forms of Romano-Ward syndrome if only a single copy of the variant is inherited.
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Drawing by Camillo Golgi of a hippocampus stained with the silver nitrate method. In 1871, a German anatomist Joseph von Gerlach postulated that the brain is a complex "protoplasmic network", in the form of a continuous network called the reticulum. Using his black reaction, Golgi could trace various regions of the cerebro-spinal axis, clearly distinguishing the different nervous projections, namely axon from the dendrites. He drew up a new classification of cells on the basis of the structure of their nervous prolongation.
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Lang, 211 A more educated populace would provide the foundation for an eventual republican or parliamentary system. Of all of Russia's social ills, Radischev especially despised the inequality and prolongation of serfdom, rooted in a traditional social system that enforced a strict hierarchy and permitted abuses and exploitation. Ironically, under Catherine's enlightened reign, serfdom was intensified and spread to newly conquered territories.McConnell, 18 While in Siberia, Radischev's economic thought developed, not only in terms of decreasing dependence on serfdom but denouncing international trade.
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In rare situations, hydroxychloroquine has been implicated in cases of serious skin reactions such as Stevens–Johnson syndrome, toxic epidermal necrolysis, and Drug reaction with eosinophilia and systemic symptoms. Reported blood abnormalities with its use include lymphopenia, eosinophilia, and atypical lymphocytosis. For short- term treatment of acute malaria, adverse effects can include abdominal cramps, diarrhea, heart problems, reduced appetite, headache, nausea and vomiting. Other adverse effects noted with short-term use of Hydroxychloroquine include low blood sugar and QT interval prolongation.
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The idea of constructing the New Ministries had been the work of Indalecio Prieto, Minister of Public Works. However, this idea had already been raised by Zuazo in his "Prolongation Project of Castellana" in 1930, so Prieto commissioned the construction of what would be the New Ministries, to house the ministries of Public Works and Government. After the demolition of the racecourse, the first stone was laid on April 15, 1933. Zuazo took the Escorial as an inspiration for the project.
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Ebastine has shown overall safety and tolerability profile with no cognitive/psychomotor impairment and no sedation worse than placebo, and cardiac safety, that is, no QT prolongation. The incidence of most commonly reported adverse events was comparable between the ebastine and placebo groups, which confirms that ebastine has a favourable safety profile. While experiments in pregnant animals showed no risk for the unborn, no such data are available in humans. It is not known whether ebastine passes into the breast milk.
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He devised methods for determining the prothrombin time, for prolongation of insulin effect and for biological standardization of liver extracts. His research findings were published by way of over 300 research papers in national and international journals. Mukerjee was the general secretary of the Indian Science Congress Association from 1946 to 1952 and presided the 49th Congress in 1962. He was a member of the council, foreign secretary and vice president of the Indian National Science Academy for various tenures.
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The Belgrade bypass () is a U-shaped, 69-km long motorway of which some 45 km is the section of A1 motorway (currently under construction) and the rest is planned eastern prolongation of A3 motorway. It partially encircles the city of Belgrade, the capital of Serbia. The construction of the bypass started in 1990 and its parts have been sporadically built ever since. Its completion is expected to help alleviate Belgrade's traffic congestion, and remove all transit traffic from the city itself.
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Nadeau says that women have been described as a sort of commodity, "skin for skin", and they were essential to the sustainable prolongation of the fur trade. Nadeau describes fur as an essential, "the fabric" of Canadian symbolism and nationhood. She notes the controversies around the Canadian seal hunt, with Brigitte Bardot as a leading figure. Bardot, a famous actress, had been a model in the 1971 "Legend" campaign of the US mink label Blackglama, for which she posed nude in fur coats.
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The therapeutic properties of ambazone were studied in lab rats and the therapeutic dose was determined to be 60–125 mg/kg of body weight. As stated above, ambazone possesses anti-septic properties shown by its increased activity against gram-positive cocci. Along with anti-septic properties, ambazone has also shown its ability to fight forms of leukemia in lab rats. When administered orally the results showed prolongation of life expectancy and curing of L1210 and P388 leukemia in lab rats.
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It should not be used concomitantly with medications known to prolong the QTc interval (e.g. 5-HT3 antagonists, tricyclic antidepressants, citalopram, etc.) as this may lead to an increased risk of QTc interval prolongation. Neither should it be given concurrently with lithium (medication) as it may increase the risk of lithium toxicity and neuroleptic malignant syndrome. It should not be given concurrently with other antipsychotics due to the potential for this to increase the risk of side effects, especially neurological side effects such as neuroleptic malignant syndrome.
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G J Gruman, A History of Ideas about Prolongation of Life, Springer Publishing, 2005, p.158 The most widely known of his many writings is the treatise entitled Makrobiotik oder Die Kunst, das menschliche Leben zu verlängern (1796), which was translated into many languages, including in Serbian by Dr. Jovan Stejić in Vienna in 1828. Of his practical works, the System of Practical Medicine (System der praktischen Heilkunde, 1818-1828) is the most elaborate. From 1795 to 1835 he published a Journal der praktischen Arznei und Wundarzneikunde.
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These are a little more prominent upon the convexity of the longitudinal ribs than in their interstices, and it is their prolongation in this part, which causes them to resemble small spines. Its color is reddish, varied with fawn-colored or clear chestnut-brown spots. Oftentimes the lower whorl presents, towards its middle, a transverse brown band, the half only of which can be seen upon the upper whorls, the whole length of the sutures. The aperture is whitish, ovate, elongated, and narrowed towards its base.
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Defects in DNAJC19 have been observed primarily in cases of dilated cardiomyopathy with ataxia (DCMA), though it has also been associated with growth failure, microcytic anemia, and male genital anomalies. DNAJC19 was first implicated in DCMA in a study on the consanguineous Hutterite population, which has since been confirmed in other European populations. In the clinic, DNAJC19 mutations can be detected by screening for elevated levels of 3-methylglutaconic acid, mitochondrial distress, dilated cardiomyopathy, prolongation of the QT interval in the electrocardiogram, and cerebellar ataxia.
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In ECG analysis, the SA is categorized into normal (below 105°), borderline abnormal (105–135°) and abnormal (greater than 135°). A broad SA results when the heart undergoes pathological changes and is reflected in a discordant ECG. A large SA indicates an altered ventricular repolarization sequence, and may be the result of structural and functional myocardial changes that induce regional shortening in action potential duration and impaired ion channel functioning. Current standard ECG markers of repolarization abnormalities include ST depression, T wave inversion and QT prolongation.
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In May 2016, construction began of a new air terminal complex with a large terminal and service buildings of more than 78,000 m2 designed for servicing 7 mln passengers a year with the possible extension of nearly 10 mln passenger a year. The general cost of works is 32 bln rubles. The construction was planned to end by summer tourist season 2018. With the end of the construction, entry of a repaired runway into service was synchronized, including the prolongation and creation of new taxiways.
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The area will contain ten buoys connected to generators and an additional numbers of buoys for environmental impact studies. The permits allow the studies to go on to the end of 2013, then all equipment has to be removed unless a prolongation is applied for and approved. The average energy flux at the research site during 2007, excluding August, was 3.4 kW/m. The most frequent sea state is characterized by an energy period, TE, around 4 sec and significant wave height Hs less than .
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The anterior end is deeply serrated and articulates with the zygomatic bone. The posterior end is connected to the squamous part by two roots, the anterior and posterior roots. The posterior root, a prolongation of the upper border, is strongly marked; it runs backward above the external auditory meatus, and is continuous with the temporal line. The anterior root, continuous with the lower border, is short but broad and strong; it is directed medialward and ends in a rounded eminence, the articular tubercle (eminentia articularis).
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1914 was a turning point in the fortress's construction - the First World War. Deliveries of cement ceased, which previously had been carried by sea from Novorossiysk, since Turkey closed the Straits. Initially, the pace of construction is not reduced because the fortress had accumulated large stocks of cement; but from 1915, with the prolongation of the war, the situation began to deteriorate. By the end of 1916, only about two-thirds of all 11 forts were ready, many of them built with only gorge barracks.
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Lorne Parish is defined in the Territorial Division Act as being bounded: :Northeasterly and northerly by Northumberland and Restigouche Counties; south by Gordon Parish; and northwesterly by the prolongation to the county of Restigouche of the line forming the northwesterly boundary of Gordon Parish, which runs a course north forty-five degrees east from the point on the Royal RoadThe Royal Road does not appear on provincial highway maps but does appear on cadastral land grant maps. eight miles north of the Tobique River.
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SSRIs do not appear to affect the risk of coronary heart disease (CHD) in those without a previous diagnosis of CHD. A large cohort study suggested no substantial increase in the risk of cardiac malformations attributable to SSRI usage during the first trimester of pregnancy. A number of large studies of people without known pre-existing heart disease have reported no EKG changes related to SSRI use. The recommended maximum daily dose of citalopram and escitalopram was reduced due to concerns with QT interval prolongation.
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Hypokalemia leads to characteristic ECG changes (QRS prolongation, ST-segment and T-wave depression, U-wave formation). The earliest electrocardiographic (ECG) findings, associated with hypokalemia, are decreased T wave height. Then, ST depressions and T inversions appear as serum potassium levels reduce further. Due to prolonged repolarization of ventricular Purkinje fibers, prominent U waves occur (usually seen at V2 and V3 leads), frequently superimposed upon T waves, therefore producing the appearance of prolonged QT intervals, when serum potassium levels fall below 3 mEq/L.
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Terfenadine is an antihistamine formerly used for the treatment of allergic conditions. It was brought to market by Hoechst Marion Roussel (now Sanofi- Aventis) and was marketed under various brand names, including Seldane in the United States, Triludan in the United Kingdom, and Teldane in Australia. It was superseded by fexofenadine in the 1990s due to the risk of a particular type of disruption of the electrical rhythms of the heart (specifically cardiac arrhythmia caused by QT interval prolongation) and has been withdrawn from markets worldwide.
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Thoracic radiotherapy generally begins with the first or second cycle when chemotherapy is used according to most guidelines. The time between the start and the end of chemoradiotherapy is a predicator of survival in limited stage small cell lung cancer, prolongation leads to a decrease in overall survival of 1.9% per week. Early concurrent radiochemotherapy may not be suitable for all patients. A deferred start of concurrent chemotherapy or even a sequential treatment is recommended for patients with large tumour volumes and poor fitness status.
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The Thanon Thong Chai Range is the southernmost prolongation of the Shan Hills and it consists of two parallel ranges running southwards from the southwestern limits of the Daen Lao Range between rivers Yuam and Ping. The eastern range is also known as Inthanon Range (ทิวเขาอินทนนท์). Often the Dawna Range further west and south is included as the western part of the Thanon Thong Chai Range. There are also some geographers who include the Thanon Thong Chai as a subrange of the Daen Lao Range.
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In clinical trials of givinostat as a salvage therapy for advanced Hodgkin's lymphoma, the most common adverse reactions were fatigue (seen in 50% of participants), mild diarrhea or abdominal pain (40% of participants), moderate thrombocytopenia (decreased platelet counts, seen in one third of patients), and mild leukopenia (a decrease in white blood cell levels, seen in 30% of patients). One-fifth of patients experienced prolongation of the QT interval, a measure of electrical conduction in the heart, severe enough to warrant temporary suspension of treatment.
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The key indication for CRT is left bundle branch block (LBBB) of the heart, a cardiac abnormality leading to delayed left ventricular contraction. LBBB causes a QRS prolongation of >120 ms on the electrocardiogram, contributing to poor left ventricular coordination and reduced systolic function, thereby reduced ejection fraction (<35%). This reduction in ejection fraction is what we consider heart failure. Heart failure patients are generally considered if in class II or III heart failure, with current guidelines indicating CRT is inappropriate for class IV heart failure.
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AZD 1305 also acts on voltage gated sodium channels (Nav1.5) by attenuating the peak (INapeak) and late sodium current (INalate), though the latter current is more potently inhibited. Attenuation of INalate by AZD1305 is concentration-dependent and decreases the slope of depolarization and delays repolarization. INalate blockade by AZD1305 depressed the threshold of sodium channel excitation and prolongs APD. Blockade of IKr may lead to excessive prolongation of APD and repolarization instability, which may promote arrhythmic conditions in the heart, including EAD and Torsade de Pointes (TdP).
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Dorchester Parish is defined in the Territorial Division Act as being bounded: :West by Petitcodiac River; north by a line running by the magnet of eighteen hundred and ninety-four; south eighty-three degrees and forty-five minutes east from the mouth of Fox Creek; east by the southeast line of lot numbered one (John Sherwood) and the prolongation thereof two hundred and fifty chains from the sea; thence north eleven degrees east by the magnet of the year seventeen hundred and sixty- five.
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A beetle leg In invertebrate biology, an appendage (or outgrowth) is an external body part, or natural prolongation, that protrudes from an organism's body (in vertebrate biology, an example would be a vertebrate's limbs). An appendage is any of the homologous body parts that may extend from a body segment. These include antennae, mouthparts (including mandibles, maxillae and maxillipeds), gills, walking legs (pereiopods), swimming legs (pleopods), sexual organs (gonopods), and parts of the tail (uropods). Typically, each body segment carries one pair of appendages.
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The greater solubility in oil allows the steroid esters to be dissolved in a smaller oil volume, thereby allowing for larger doses with intramuscular injection. In addition, the greater the lipophilicity of the steroid, as measured by the octanol/water partition coefficient (logP), the slower its release from the oily depot at the injection site and the longer its duration. Steroid esters can also be prepared as crystalline aqueous suspensions. Aqueous suspensions of steroid crystals result in prolongation of duration with intramuscular injection similarly to oil solutions.
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By decreasing the ion permeability of these channels, HBI-3000 slightly prolongs APD (due to IKr); however, unlike pure IKr channel blockers, it is self-limited (due to the decreased permeability of INa-L and ICa-L). This is similar to the medications ranolazine and amiodarone. HBI-3000 suppresses early afterdepolarizations (EADs; a change in the normal net flow of ions during repolarization), does not produce any electrical abnormalities, and displays minimally pronounced prolongation of APD during a slow heart rate (i.e. stimulated at a slower frequency).
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Clinically, the patients are characterized by only modest QT prolongation, but an increased propensity for atrial arrhythmias. LQT14, LQT15 and LQT16 are caused by variants in the genes responsible for calmodulin (CALM1, CALM2, and CALM3 respectively). Calmodulin interacts with several ion channels and its roles include modulation of the L-type calcium current in response to calcium concentrations, and trafficking the proteins produced by KCNQ1 and thereby influencing potassium currents. The precise mechanisms by which means these genetic variants prolong the QT interval remain uncertain.
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In the run up to the 2009 elections (Presidential, Assembly, and Municipal), a movement to draft President Tandja for a third term appeared. Led by public figures of the MNSD outside government, the group took the name of Tandja's 2004 re-election slogan, Tazarce: a Hausa word meaning "Continuity". Through several well funded and well attended public rallies in late 2008, the President remained silent on the calls for him to remain.Le Président Tandja reste muet sur les appels en faveur d’une prolongation de son mandat.
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Despite this, about 125 houses were demolished, 28 of which were tiled in the very specific way Cabanyal houses are tiled. In 2013, the conflict in Cabanyal was still ongoing. That year, 272 tiled houses were catalogued, with 139 of those protected and 43 marked to be demolished by the expansion plan. After Barberà's team lost the local elections in 2015, the new left-sided local council with the mayor Joan Ribó paralyzed the plans of demolition and prolongation of the avenue Blasco Ibáñez.
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It is advised that those using Isradipine not take Anzemet (Dolasetron), as both agents can cause a dose- dependent PR interval and QRS complex prolongation. Itraconazole exhibits a negative inotropic effect on the heart and thus could spur an additive effect when used concomitantly with Isradipine. Onmel/Sporanox also inhibits an important cytochrome liver enzyme (CYP 450 3A4) which is needed to metabolize Isradipine and other Calcium Channel Blockers. This will increase plasma levels of Isradipine and could cause an unintentional overdose of the medication.
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Foraging and nuptial behaviour of Poecilobothrus nobilitatus (video, 2m 58s) Many studies have shown that Dolichopodidae give visual, rather than chemical or other signals during courtship.E.g. Zimmer et al. (2003), Irwin (2007), Vikhrev (2007) The males of many species exhibit elaborate secondary sexual characters assumed to aid in species recognition during courtship. These characters include flaglike flattening of the arista and tarsi, strongly modified setae and projections of the tarsi, the prolongation and deformation of podomeres, orientated silvery pruinosity, and maculation or modification of the wings.
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Concentrations of midazolam or its major metabolite, 1-hydroxymidazolam glucuronide, may be measured in plasma, serum, or whole blood to monitor for safety in those receiving the drug therapeutically, to confirm a diagnosis of poisoning in hospitalized patients, or to assist in a forensic investigation of a case of fatal overdosage. Patients with renal dysfunction may exhibit prolongation of elimination half-life for both the parent drug and its active metabolite, with accumulation of these two substances in the bloodstream and the appearance of adverse depressant effects.
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An urgent build-up leads to a sudden crash, build up with a F major two hands octaves as a transition point, to the last B♭ major melodie play along with the orchestra, and it fuses into a dramatic and extended climatic episode, gradually building up to a triumphant dominant prolongation. Then the melodies from the B theme is heard triumphantly in B major. After that, the final part of the coda, marked allegro vivo, draws the work to a conclusion on a perfect authentic cadence.
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Delta atracotoxin is responsible for the potentially lethal envenomation syndrome seen following funnel-web spider envenomation. d-Atracotoxins induce spontaneous, repetitive firing and prolongation of action potentials resulting in continuous acetylcholine neurotransmitter release from somatic and autonomic nerve endings. This will lead to slower voltage-gated sodium channel inactivation and a hyperpolarizing shift in the voltage-dependence of activation. This action is due to voltage- dependent binding to neurotoxin receptor site-3 in a similar, but not identical, fashion to scorpion a-toxins and sea anemone toxins.
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Such drug interactions are associated with the molecular structural modifications of the quinolone ring, specifically interactions involving NSAIDS and theophylline. As such, these drug interactions involving the fluoroquinolones appear to be drug specific rather than a class effect. The fluoroquinolones have also been shown to interfere with the metabolism of caffeine and the absorption of levothyroxine. The interference with the metabolism of caffeine may lead to the reduced clearance of caffeine and a prolongation of its serum half-life, resulting in a caffeine overdose.
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Paphlagonia (; , Paphlagonía, modern pronunciation Paflagonía; ) was an ancient region on the Black Sea coast of north central Anatolia, situated between Bithynia to the west and Pontus to the east, and separated from Phrygia (later, Galatia) by a prolongation to the east of the Bithynian Olympus. According to Strabo, the river Parthenius formed the western limit of the region, and it was bounded on the east by the Halys river. The name Paphlagonia is derived in the legends from Paphlagon, a son of Phineus. (Eustath. ad Horn.
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Howard had bought gold on margin May 17, and started the ruse because he knew that any news of a prolongation of the war would cause a rise in the price of gold when investors wanted to transfer their savings elsewhere. He had forged the two AP dispatches, and sent them to various city newspapers in an appropriate time. The next day, during the furor, he had sold his investment and profited immensely. Howard spent only three months in prison and was released on August 22, 1864.
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In Western classical music during the common practice period, chord progressions are used to structure a musical composition. The destination of a chord progression is known as a cadence, or two chords that signify the end or prolongation of a musical phrase. The most conclusive and resolving cadences return to the tonic or I chord; following the circle of fifths, the most suitable chord to precede the I chord is a V chord. This particular cadence, V–I, is known as an authentic cadence.
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Queensbury Parish is defined in the Territorial Division Act as being bounded: :Northeast by Bright Parish; south and southwest by the Saint John River; and northwest by a line commencing at the Saint John River, at the southern angle of lot number one, granted to Joseph Cunliff, near the mouth of the Nackawic Stream; thence running northeasterly along the lower or southeastern line of said lot and its prolongation until it strikes the southwestern line of land granted to William Dobie, in Caverhill; thence northwesterly along the said line of said grant and its prolongation till it strikes the southeastern line of a grant to Henry Morehouse and three others; thence northeasterly along the line of said grant to its eastern angle; thence northwesterly along the northeast side of the said grant till it strikes the East Branch Nackawic Stream; thence following the course of the said river up stream to the forks at the mouth of the Burtt Lake Branch and thence following the course of the said Burtt Lake Branch up stream till it strikes the line of the parish of Bright.
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Due to the narrow therapeutic index of flecainide, physicians should be alert for signs of toxicity before life-threatening arrhythmias occur like torsades de pointes. While the toxic effects of flecainide are closely related to the plasma levels of the drug, it is unfeasible to check the plasma concentration in an individual on a regular basis. Signs of flecainide toxicity include marked prolongation of the PR interval and widening of the QRS duration on the surface ECG. There may be signs and symptoms attributable to overt heart failure secondary to sudden decreased myocardial contractility.
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A common exchange of this sort involves a progression of a third using a passing tone, the exchange notated by the interval succession 10-8-6 (if this is with the bass, the third chord is a first inversion of the first). This is in effect a prolongation of the third (generally as part of a triad), a preservation of the harmony across a time span.Forte and Gilbert, 111. Another type of exchange has the interval succession 10-10-6-6 (or 6-6-10-10) and involves a pair of notes exchanged across parts.
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Hypokalemia (low blood potassium levels) commonly occurs during attacks; levels below 3.0 mmol/l are typically encountered. Magnesium and phosphate levels are often found to be decreased. Creatine kinase levels are elevated in two thirds of cases, usually due to a degree of muscle injury; severe elevations suggestive of rhabdomyolysis (muscle tissue destruction) are rare. Electrocardiography (ECG/EKG) may show tachycardia (a fast heart rate) due to the thyroid disease, abnormalities due to cardiac arrhythmia (atrial fibrillation, ventricular tachycardia), and conduction changes associated with hypokalemia (U waves, QRS widening, QT prolongation, and T wave flattening).
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Tendon damage may manifest during and up to a year after fluoroquinolone therapy has been completed. Fluoroquinolones prolong the QT interval by blocking voltage-gated potassium channels. Prolongation of the QT interval can lead to torsades de pointes, a life-threatening arrhythmia, but in practice, this appears relatively uncommon in part because the most widely prescribed fluoroquinolones (ciprofloxacin and levofloxacin) only minimally prolong the QT interval. Clostridium difficile-associated diarrhea may occur in connection with the use of any antibacterial drug, especially those with a broad spectrum of activity such as clindamycin, cephalosporins, and fluoroquinolones.
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Chemotherapy may be combined with palliative care in the treatment of the NSCLC. In advanced cases, appropriate chemotherapy improves average survival over supportive care alone, as well as improving quality of life. With adequate physical fitness maintaining chemotherapy during lung cancer palliation offers 1.5 to 3 months of prolongation of survival, symptomatic relief, and an improvement in quality of life, with better results seen with modern agents. The NSCLC Meta-Analyses Collaborative Group recommends if the recipient wants and can tolerate treatment, then chemotherapy should be considered in advanced NSCLC.
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Although drawing on the sculptural traditions of India, and the religious iconography of Buddhism and Hinduism, Nepalese sculpture evolved into its own distinctive style, with a tendency towards more ornate flourishes, exaggerated physical postures and elongated depictions of facial features. In Nepal, as in Tibet, "the last phase of Buddhist art in India enjoyed a prolongation of nearly a thousand years",Rowland, 232 as Buddhism virtually disappeared in India itself. Style in metal continued to develop until recent centuries,Harle, 474 until about the 17th century, after which it changed little.
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One of them says it is in E, another says it is a prolongation of F as the dominant of B, and the third concludes that it is in G. While all three are persuasive in their own way, other keys may also be heard here, but all are insubstantial. Any complete analysis must take these ghostly remnants of tonality into account, but no one key reliably shapes the structure . Atonal analyses of this first piece are also divided in opinion. Allen Forte describes its pitch organisation as "straightforward" and based on hexachords .
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Hopewell Parish is defined in the Territorial Division Act as being bounded: :North by Hillsborough Parish; southeast by Chignecto Bay; and southwest by a line commencing at the mouth of Shepody River; thence up the centre of the said river to the mouth of Crooked Creek; thence up the centre of the said creek to the old bridge over the same on the old main road;Neither road nor bridge appear on provincial highway maps. and thence north twenty degrees west to intersect the south line of Hillsborough Parish or its westerly prolongation.
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Benedict deals with the topic of eternal life, explaining that it is not a mere prolongation of existence but the blissful completion of life. He points out that in the baptismal rite the parents presenting the child ask for faith because faith brings eternal life. > Perhaps many people reject the faith today simply because they do not find > the prospect of eternal life attractive. What they desire is not eternal > life at all, but this present life, for which faith in eternal life seems > something of an impediment.
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The Baetic System is made up of multiple mountain ranges that reach from western Andalusia to the Region of Murcia, southern Castile-La Mancha and the Land of Valencia. To the north, the Baetic Ranges are separated from the Meseta Central and the Sierra Morena by the basin of the Guadalquivir. The Iberian System rises north of the eastern part of the Prebaetic System, the northernmost prolongation of the Baetic System. Generally the mountain ranges that are part of this system are aligned in a southwest-northeast direction.
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In differential topology, the jet bundle is a certain construction that makes a new smooth fiber bundle out of a given smooth fiber bundle. It makes it possible to write differential equations on sections of a fiber bundle in an invariant form. Jets may also be seen as the coordinate free versions of Taylor expansions. Historically, jet bundles are attributed to Charles Ehresmann, and were an advance on the method (prolongation) of Élie Cartan, of dealing geometrically with higher derivatives, by imposing differential form conditions on newly introduced formal variables.
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An advisory committee of the U.S. Food and Drug Administration (FDA) voted against the approval of oliceridine in 2018, due to concerns that the benefit of the drug did not exceed the risk. The risks of oliceridine include prolongation of the QT interval on the ECG, and depression of the respiratory drive (which could cause a person to stop breathing). As a result of the committee's vote, the FDA declined to approve oliceridine, citing safety concerns. Oliceridine was approved for medical use in the United States in August 2020.
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The Lee–Boot effect is a phenomenon concerning the suppression or prolongation of oestrous cycles of mature female mice (and other rodents), when females are housed in groups and isolated from males. It is caused by the effects of an estrogen-dependent pheromone, possibly 2,5-dimethylpyrazine, which is released via the urine and acts on the vomeronasal organ of recipients. This pheromone lowers the concentration of luteinizing hormone and elevates prolactin levels, synchronising or stopping the recipient's cycle. This effect goes some way to explain why spontaneous pseudopregnancy can occur in mice.
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McGrory and Garber reported a significant prolongation of T. vaginalis infection in estrogenized BALB/c mice intravaginally preinoculated with cells of L. acidophilus ATCC 4356 (originating from the human pharynx) in comparison to animals that had not been pretreated. Although initial infectivity in the two groups was comparable, at day 24 post-infection 69% of L. acidophilus-inoculated mice still showed positive T. vaginalis cultures, compared with only 11% of mice not harboring lactobacilli. Other hypothesized risk factors of colonization by lactobacilli of low protective value in general include prior antimicrobial treatment and congenital factors.
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Schematic diagram of the human eye Hyaloid canal (Cloquet's canal and Stilling's canal) is a small transparent canal running through the vitreous body from the optic nerve disc to the lens. It is formed by an invagination of the hyaloid membrane, which encloses the vitreous body. In the fetus, the hyaloid canal contains a prolongation of the central artery of the retina, the hyaloid artery, which supplies blood to the developing lens. Once the lens is fully developed the hyaloid artery retracts and the hyaloid canal contains lymph.
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In music theory, prolongation is the process in tonal music through which a pitch, interval, or consonant triad is able to govern spans of music when not physically sounding. It is a central principle in the music-analytic methodology of Schenkerian analysis, conceived by Austrian theorist Heinrich Schenker."It is one of the most valuable services of Schenkerian theory to have revealed for the first time the unity of composing-out and the prolonged application and validity of the laws of voice leading." Oswald Jonas, Introduction to the Theory of Heinrich Schenker, trans.
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The historical roots of Catholic eucharistic theology begin with the same sources as do other Christian churches who express their faith in the "bread of life" found in the words of Jesus in Scripture. These include the Hebrew and Christian scriptures, the Church Fathers, and later Christian writers. While the word "Eucharist" (from the Greek) refers to Christ's prolongation of the Jewish Passover or "thanksgiving" meal, the gift of Communion, whereby, as Paul says, he fashions us into one body in him, came to signify God's greatest gift, for which Christians are most thankful.
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The pointed spire is composed of five or six distinct, convex whorls. The body whorl is much larger than all the others together, presenting at the base a pretty deep decurrent suture. The aperture is whitish, ovate, elongated, and terminates at the base by a very oblique emargination, and above by a canal formed by the prolongation, upon the columella, of a callosity which becomes there a thin sharp plate. This plate presents the appearance of a partition extending towards the left lip ; the outer lip is much elongated, thin and sharp.
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Case reports have noted cardiac arrhythmias emerging in relation to trazodone treatment, both in patients with pre-existing mitral valve prolapse and in patients with negative personal and family histories of cardiac disease. QT prolongation has been reported with trazodone therapy. Arrhythmia identified include isolated PVCs, ventricular couplets, and in two patients short episodes (three to four beats) of ventricular tachycardia. Several post- marketing reports have been made of arrhythmia in trazodone-treated patients who have pre-existing cardiac disease and in some patients who did not have pre-existing cardiac disease.
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Fenspiride (INN, brand names Eurespal, Pneumorel and others) is an oxazolidinone spiro compound used as a drug in the treatment of certain respiratory diseases. The pharmacotherapeutic classification is antitussives. In Russia it was approved for the treatment of acute and chronic inflammatory diseases of ENT organs (ear, nose, throat) and the respiratory tract (like rhinopharyngitis, laryngitis, tracheobronchitis, otitis and sinusitis), as well as for maintenance treatment of asthma.. Russia, Romania, France and other European countries withdrew fenspiride-based drugs from the market due to the risk of QT prolongation and torsades de pointes.
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Lasiognathus intermedius is a species of wolftrap angler known from the western Atlantic Ocean and the southeastern Pacific Ocean where it occurs at depths of around . The females of this species grow to a length of SL. This species has an elongated, cylindrical distal appendage with a short, cylindrical prolongation at the tip without any lateral serrations or filaments. The posterior escal appendage is cylindrical in shape. Its species name refers to its esca being intermediate in shape between those of L. beebei and those of L. saccostoma and L. waltoni.
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He was interested in finding a prolongation of the Saar basin, and played a role in discovery of the mines of the Pas-de-Calais. When undertaking exploratory drilling for coal in 1907, at a depth of a source of very pure water was found that gushes into the open air at a temperature of . Fernand de Saintignon decided that he would use this water for a spa. The Hotel des Récollets was built in 1912 for people seeking cures for arthritis from the water of the Récollets spring.
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The director declared that the idea of the film was born on April 1, 2008 when he decided to cover an act by President Fernández of Kirchner in support of this resolution. The initial aim was to produce a special program for television but afterwards with the prolongation and deepening of the conflict, it was transformed into a film. Produced by the state body National Institute of Cinema and Audiovisual Arts (NICAA) it was premiered in cinemas on 21 May 2009 and was exhibited on the state television channel two days later.
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The siege began with knights, infantry, and siege engines and included the plundering of the environs of the city and assaults on its walls. The arrival of a relief army led to a famous joust and the prolongation of the siege. The siege was a failure, and was lifted after Alfonso had made his famous last will and testament. The primary sources are insufficient to fully explain the purposes behind Alfonso's siege, but historians are unanimous in attributing his actions to his ongoing conflict with his western neighbour, Alfonso VII, hero of the aforementioned Chronica.
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At the beginning of February 1918, Bogdanov denied that the Bolsheviks' October rise to power had constituted a conspiracy. Rather, he explained that an explosive situation had arisen through the prolongation of the war. He pointed to a lack of cultural development in that all strata of society, whether the bourgeoisie, the intelligentsia, or the workers, had shown a failure to resolve conflicts through negotiation. He described the revolution as being a combination of a peasant revolution in the countryside and a soldier-worker revolution in the cities.
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North Korea disputes with China a number of small islands at the mouth of the Yalu. The ownership of these islands affects the possible course that the maritime border between the two countries, and thus the border of their respective EEZs, will take. North Korea has specified its EEZ using the equidistant line method, while China, in general, prefers the natural prolongation of land territory method. In the Korean Bay in the Yellow Sea, however, China also prefers the equidistant line method, because that would give it the maximum share of the waters.
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'Araqhama is a western prolongation of the main settlement, across the Patakancha River; it features a large plaza, called Manyaraki, surrounded by constructions made out of adobe and semicut stones. These buildings have a much larger area than their counterparts in the main settlement; they also have very tall walls and oversized doors. To the south are other structures, but smaller and built out of fieldstones. Araqhama has been continuously occupied since Inca times, as evidenced by the Roman Catholic church on the eastern side of the plaza.
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The find has been variously dated, but the first or second century AD is the most probable guess. One authority states that on grounds of paleography the inscription can be "securely dated to the first century C.E.", while on the same basis (the use of swallow-tail serifs, the almost triangular Φ with prolongation below, ligatures between N, H, and M, and above all the peculiar form of the letter omega) another is equally certain it dates from the second century AD, and makes comparisons to dated inscriptions of 127/8 and 149/50 AD.
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Most wines produced from Băbească Neagră are light-bodied, fruity red wines. Being an old grape variety, Băbească neagră has demonstrated significant clonal variations including Copceac – a variation with bigger berries, Coada Rândunicii (Swallowtail) - a variation with a bisected bunch and Coada Vulpii (Foxtail) — a variation that has a cylindrical prolongation of the bunch. It has also produced over the years two color mutations including a pink-berried mutation which is called Băbească gri in Romania and Sereksiya rose in Finger Lakes, and a white-berried mutation known as Băbească albă.
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Rodalies de Catalunya railway station is located under Avinguda Vilanova between Passeig de San Joan and Nàpols street. It was opened in 1933 as a prolongation to the city center on Puigcerdà and Manresa lines which had its terminus station in Estació del Nord, situated near the current railway station. It has two groups of accesses, one in Passeig de Sant Joan and the other one in Nàpols street. The accesses to the platforms are equipped with fixed stairs and both go to the same hall, where there are ticket vending machines.
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These reactions worsen with larger crystals, and for this reason, crystal sizes must be limited to minimize local reactions. Particle sizes of more than 300 μg in the case of estradiol benzoate by intramuscular injection have been found to be too painful for use. In some cases, crystalline steroid suspensions are used not for prolongation of effect, but because the solubility of the steroid result in this preparation being the only practical way to deliver the steroid in a reasonable injection volume. Examples include cortisone acetate and hydrocortisone and its esters.
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Other causes of acquired LQTS include abnormally low levels of potassium (hypokalaemia) or magnesium (hypomagnesaemia) within the blood. This is can be exacerbated following a sudden reduction in the blood supply to the heart (myocardial infarction), low levels of thyroid hormone (hypothyroidism), and a slow heart rate (bradycardia). Anorexia nervosa has been associated with sudden death, possibly due to QT prolongation. The malnutrition seen in this condition can sometimes affect the blood concentration of salts such as potassium, potentially leading to acquired long QT syndrome, in turn causing sudden cardiac death.
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However, some suggest that the arrhythmia sustains through a mechanism known as re-entry. According to this model, the action potential prolongation occurs to a variable extent in different layers of the heart muscle with longer action potentials in some layers than others. In response to a triggering impulse, the waves of depolarisation will spread through regions with shorter action potentials but block in regions with longer action potentials. This allows the depolarising wavefront to bend around areas of block, potentially forming a complete loop and self-perpetuating.
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Characteristic ECG patterns associated with the three major subtypes of inherited Long QT syndrome Long QT syndrome is principally diagnosed by measuring the QT interval corrected for heart rate (QTc) on a 12-lead electrocardiogram (ECG). Long QT syndrome is associated with a prolonged QTc, although in some genetically proven cases of LQTS this prolongation can be hidden, known as concealed LQTS. The QTc is less than 450 ms in 95% of normal males, and less than 460 ms in 95% of normal females. LQTS is suggested if the QTc is longer than these cutoffs.
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The route taken is up to the arch and then around its side, out of respect for the tomb and its symbolism. Both Hitler in 1940 and de Gaulle in 1944 observed this custom. By the early 1960s, the monument had grown very blackened from coal soot and automobile exhaust, and during 1965–1966 it was cleaned through bleaching. In the prolongation of the Avenue des Champs-Élysées, a new arch, the Grande Arche de la Défense, was built in 1982, completing the line of monuments that forms Paris's Axe historique.
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The extensions for line 3 proposals were different over time. In the 2005 general plan, the line was supposed to turn sharply from Chevony Khutir to Darnytsia railway station, with subsequent extension to Livoberezhna. Presumably, the offer was declined, as later plans do not include any line's prolongation beyond Chervony Khutir. In April 2017, Kyiv's Mayor Vitaliy Klychko and Ukraine's Minister of infrastructure, Volodymyr Omelyan, announced they: "were talking about the project of subway extension from "Boryspilska" metro station to "Boryspil" airport with the help of private financing", although the project's ca.
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Next year he was one of those appointed to procure a prolongation of the truce with France, and one of the ambassadors to negotiate a marriage between Henry V and Catherine of France. In August 1415 he was employed to negotiate a truce with Robert Stewart, Duke of Albany, regent of Scotland, and shortly after was made Warden of the Eastern Marches. In 1418 he was Governor of the Castle of Argentan in Normandy. Grey was summoned to parliament from 17 September 1397, and was made a Knight of the Garter in about 1404.
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The main artillery fired a shell weighing , which would penetrate of iron plate at . They were carried some above the water line, and each had a firing arc of 270 degrees. The manufacture of these guns took a much greater time than had been expected; this delay was the reason for the unusual prolongation of the time between the laying down of the ship and her completion. During a refit in 1901, her 6-pounder quick-firing Hotchkiss guns were replaced with 6-pounder quick- firing mark I Nordenfelt guns.
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Referring to the Roman Republic, Machiavelli begins Chapter 24 establishing that "...two things were the cause of the dissolution of that republic: one was the contentions that arose from Agrarian law; the other, the prolongation of commands. If these things had been known well from the beginning, and proper remedies produced for them, a free way of life would have been longer and perhaps quieter."trans. by Mansfield, p. 270 If one was to decipher Machiavelli's statement into modern terms, he believes that bureaucracy and inefficiency resulted in the demise of the Roman Republic.
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July 14, 2003 The afternoon schedule of television networks covering the Impeachment were pre-empted by the prolongation of the day's court session due to the issue of this envelope. The evening telenovelas of networks were pushed back for up to two hours. That night, anti-Estrada protesters gathered in front of the EDSA Shrine at Epifanio de los Santos Avenue, not too far away from the site of the 1986 People Power Revolution that overthrew Ferdinand Marcos. A political turmoil ensued and the clamor for Estrada's resignation became stronger than ever.
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Prince William Parish is defined in the Territorial Division Act as being bounded: :Southeast by Kingsclear and Manners Sutton Parishes; southwest by the eastern lines of the grants to the New Brunswick and Canada Railway and Land Company, east of the Canadian Pacific Railroad, said lines being commonly called, “The Belt Line,” northwest by the lower line of lot numbered one hundred and forty-three, granted to the rector, church wardens and vestry of Saint Clement’s [Anglican] church, in said parish, and its southwesterly prolongation; northeast by the Saint John River.
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The pivots were located under the two boiler saddles and were carried on centre bearings which formed part of the engine unit frames. Not a CGR Double Fairlie, but showing the type's central firebox and cramped cab workspace The steam pipes were routed across the front tube- plates into fittings which formed a prolongation of the bottom part of the smokeboxes. From there, steam passed through a swivelling and sliding joint to the cylinders. The exhaust pipes back to the smokeboxes were equipped with ball and socket joints.
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This process occurs gradually, and experimental studies have revealed patchy atrial fibrosis may precede the occurrence of atrial fibrillation and may progress with prolonged durations of atrial fibrillation. Fibrosis is not limited to the muscle mass of the atria and may occur in the sinus node (SA node) and atrioventricular node (AV node), correlating with sick sinus syndrome. Prolonged episodes of atrial fibrillation have been shown to correlate with prolongation of the sinus node recovery time; this suggests that dysfunction of the SA node is progressive with prolonged episodes of atrial fibrillation.
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The peripheral autonomic nervous system, central nervous system and the heart are the main systems that are affected following overdose. Initial or mild symptoms typically develop within 2 hours and include tachycardia, drowsiness, a dry mouth, nausea and vomiting, urinary retention, confusion, agitation, and headache. More severe complications include hypotension, cardiac rhythm disturbances, hallucinations, and seizures. Electrocardiogram (ECG) abnormalities are frequent and a wide variety of cardiac dysrhythmias can occur, the most common being sinus tachycardia and intraventricular conduction delay resulting in prolongation of the QRS complex and the PR/QT intervals.
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He was also engaged in observations in Shetland with Édouard Biot, who had been deputed by the Institut de France to make pendulum and other observations there in connection with the prolongation of the arc of the meridian. Biot and Colby fell out, however. Colby later accompanied General Mudge to Dunkirk, and took part in the observations made, with Biot and François Arago, using Jesse Ramsden's sector, which was set up in Dunkirk arsenal. In 1819 Colby was again engaged in Scotland, the season's work beginning, early in May, on Corrie Habbie, Banff, and ending in Caithness at the end of September.
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The "HOHMS Paradigm" posits that treatment regimens for lung cancer patients should be based on a high level of histological and molecular stratification to maximize response rates and survival prolongation, and minimize toxicity. The choice of regimen should be based, insofar as is possible, on the results of large-scale randomized clinical trials. When large-scale trials have not been conducted, meta-analyses of databases of patient series and case reports can be utilized. Histological stratification should be based on subtypes recognized in the 2004 revision of the World Health Organization (WHO) lung tumor typing system.
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Khao Yai National Park The province is at the west end of the Khorat Plateau, separated from the Chao Phraya river valley by the Phetchabun and Dong Phaya Yen mountain ranges. Two national parks are in the province: Khao Yai in the west and Thap Lan in the south. Both parks are in the forested mountains of the Sankamphaeng Range, the southern prolongation of the Dong Phaya Yen mountains Nakhon Ratchasima is a large province on the northeastern plateau and acts as a gateway to other provinces in the northeast. It is from Bangkok and has an area of around .
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Prolongation refers to the number of morae (beats of time) that are pronounced when a voweled letter (', ', ') is followed by a madd letter (alif, yāʼ or wāw). The number of morae then becomes two. If these are at the end of the sentence, such as in all the verses in "al-Fatiha", then the number of morae can be more than two, but must be consistent from verse to verse. Additionally, if there is a maddah sign over the madd letter, it is held for four or five morae when followed by a ' () and six morae when followed by a '.
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The clotting time is based on a relative scale and requires a baseline value for comparison due to inconsistencies between the source and formulation of the activator being used. It is usually ordered in situations where the partial thromboplastin time (PTT) test may take an excessive amount of time to process or is not clinically useful. Prolongation of the ACT may indicate a deficiency in coagulation factors, thrombocytopenia, or platelet dysfunction. Clotting time measurements can be affected by drugs such as warfarin, aprotinin, and GpIIb/IIIa inhibitors, and physiologic disturbances such as hypothermia, hypervolemia, and hypovolemia.
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Mixing studies are tests performed on blood plasma of patients or test subjects to distinguish factor deficiencies from factor inhibitors, such as lupus anticoagulant, or specific factor inhibitors, such as antibodies directed against factor VIII. The basic purpose of these tests is to determine the cause of prolongation of Prothrombin Time (PT), Partial Thromboplastin Time, or sometimes of thrombin time (TT). Mixing studies take advantage of the fact that factor levels that are 50 percent of normal should give a normal Prothrombin time (PT) or Partial thromboplastin time (PTT) result. Factor deficient plasmas (Adsorbed Plasma & Aged Plasma, etc.) are used in mixing studies.
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The diagnosis of haemophilia C (factor XI deficiency) is centered on prolonged activated partial thromboplastin time (aPTT).One will find that the factor XI has decreased in the individuals body. In terms of differential diagnosis one must consider: hemophilia A, hemophilia B, lupus anticoagulant and heparin contamination. The prolongation of the activated partial thromboplastin time should completely correct with a 1:1 mixing study with normal plasma if haemophilia C is present; in contrast, if a lupus anticoagulant is present as the cause of a prolonged aPTT, the aPTT will not correct with a 1:1 mixing study.
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The original modern hypothesis of the positive role played by certain bacteria was first introduced by Russian scientist and Nobel laureate Élie Metchnikoff, who in 1907 suggested that it would be possible to modify the gut microbiota and to replace harmful microbes with useful microbes.Élie [Ilya Ilyich] Metchnikoff, 2004 [1907], The prolongation of life: Optimistic studies, p. 116. Springer Classics in Longevity and Aging, New York, NY:Springer, , reprint of 1908 English edition by É.M., same title (P. Chalmers Mitchell, Ed.), New York, NY:Putnam, , itself a translation of 1907 French edition by I.I.M., Essais optimistes, Paris:Heinemann, Retrieved 12 November 2015.
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Food, in particular fat, enhances the absorption of both artemether and lumefantrine, and patients are advised to take the tablets with food as soon as a meal can be tolerated. Coartem has a potential to prolong the QT interval, so combinations with other drugs having that property can cause irregular heartbeat, potentially leading to lethal ventricular fibrillation. The combination with halofantrine, another antimalarial, can cause a life-threatening QT prolongation. Drugs and other substances influencing the activity of the liver enzyme CYP3A4, including grapefruit juice, can either increase or lower blood levels of artemether/lumefantrine, depending on the sort of substance.
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The semitendinosus is more superficial than the semimembranosus (with which it shares very close insertion and attachment points). However, because the semimembranosus is wider and flatter than the semitendinosus, it is still possible to palpate the semimembranosus directly. At its insertion it gives off from its lower border a prolongation to the deep fascia of the leg and lies behind the tendon of the sartorius, and below that of the gracilis, to which it is united. These three tendons form what is known as the pes anserinus, so named because it looks like the foot of a goose.
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The Sierra de Los Filabres belongs to the Penibaetic System and forms the southern limit of the Almanzora Valley. Besides its highest point, the 2,168 m high Calar Alto, other important peaks are the Tetica de Bacares or "La Tetica" (2,086 m), a breast-shaped hill,Tetica de Bacares, Sierra de los Filabres and the Calar Gallinero (2,049 m).Almerinatura - Sierra de Los Filabres The Sierra de Los Filabres is an eastern prolongation of the Sierra de Baza mountain range in the same system. There are picturesque towns in this range, like Olula de Castro,Sierra de Los Filabres, Almeria, Andalucia, Spain.
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There is no agreement on what term to use to refer to the three narratives as a category. In all three, the central human figure avoids his imminent death by making offerings to the chasa, the gods of death, who spare him and—in most versions—take another soul in his place. Some scholars emphasize the prolongation of life and refer to "life extension" () myths or narratives, while others stress the fact that a life is taken in place of another and speak of "life replacement" () narratives. Choi Won-oh uses the term "chasa veneration" (, ) narratives.
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The lunules in the submarginal row are very strongly developed, the apices of each lunule being elongated towards the margin; the tail formed by the prolongation of the middle median nervule is very marked, being nearly 3/8 inch long. Underside. All the spots on both wings larger than on the upperside. Anterior wings with the first four spots of the submarginal row confluent with those of the marginal row, and the others nearly so. Posterior wings with the apices of the submarginal lunules much elongated, almost extending to the spots of the marginal row, which are fully developed.
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Because of that, the company directory sent Frank Parish and C.O. Barker (President and Secretary of the company, respectively) to Buenos Aires with the purpose to deal with the Government to avoid cancellation of the concession. The parties finally make an agreement that established BAGSR compromise to build two extensions of the line: one from Azul to Bahía Blanca and the second from Ayacucho to Tandil. The contract signed on October 1881 ruled that the train would reach the city of Tandil within the three subsequent years. The prolongation of the line from Ayacucho began in 1882.
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The Confederates, part of General A. P. Hill's forces, were massing for an attack on the Union line north of the Chambersburg Pike, as Stone could see from his position. Stone's official report described the attack, which began about 1:30. He had been able to watch their formation for at least 2 miles: > It appeared to be a nearly continuous line of deployed battalions, with > other battalions in mass or reserve. Their line being formed not parallel > but obliquely to ours, their left first became engaged with the troops on > the northern prolongation of Seminary Ridge.
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Woodroffe North (also known as just Woodroffe) is a neighbourhood in Bay Ward in the west end of Ottawa, Ontario, Canada. It is bounded on the south by Richmond Road on the west by the Sir John A. Macdonald Parkway, on the north by the Ottawa River and on the east by the northern prolongation of Sherbourne Avenue. Woodroffe North has also been referred to as a community within the neighbourhood of Westboro (also known as Westboro Village) which claims its western border to be Woodroffe Avenue. The Woodroffe North Community includes residents that live on streets West of Woodroffe Avenue.
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There has been no spectacular corroboration of any of its > founding principles... After more than 200 years, we are still waiting for > homeopathy "heretics" to be proved right, during which time the advances in > our understanding of disease, progress in therapeutics and surgery, and > prolongation of the length and quality of life by so-called allopaths have > been breathtaking. The true skeptic therefore takes pride in closed > mindedness when presented with absurd assertions that contravene the laws of > thermodynamics or deny progress in all branches of physics, chemistry, > physiology, and medicine. He has also described homoeopathy as a "cruel deception".
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In other words, an additional fee for the filing of divisional applications of the second or any further generation was introduced. The amount of the additional fees was announced in December 2013. The purpose of the additional fee is "to discourage the filing of long sequences of divisional applications", so as to also discourage "the prolongation of pendency periods". The "use of divisional applications as a tool for prolonging the pendency of subject-matter before the EPO" has been regarded by the EPO as "detrimental to legal certainty for third parties as well as to patent office workloads".
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Puig Neulós () is the highest mountain of Albera Range, an eastern prolongation of the Pyrenees in Catalonia, between France and Spain. It has an elevation of 1,256 metres above sea level.. There are some antennas on the summit and there is a paved road on the French side restricted to military use. The summit, as well as most of the southern side of the range is part of the Paratge Natural d'Interès Nacional de l'Albera natural reserve.Paratge Natural d'Interès Nacional de l'Albera A man-made rock formation known as La Reyne de las Founs surrounds a water source coming out of the mountain.
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Parncutt, R. (1993). Pitch properties of chords of octave-spaced tones. Contemporary Music Review, 9, 35–50 He argues that the tonic (or main psychological pitch reference) in major-minor music is generally a chord rather than a tone or a scale; the theory is consistent with Heinrich Schenker's idea that a passage of a music is a prolongation of its tonic triadThe tonic as triad: Key profiles as pitch salience profiles of tonic triads. Music Perception, 28, 333–365. doi: 10.1525/mp.2011.28.4.333 as well as Carol Krumhansl's key profiles.Krumhansl, C. L. (1990). Cognitive foundations of musical pitch.
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Her ovaries develop, her abdomen becomes distended with eggs, and she loses the ability to fly. After the founding phase has been completed, the colony encounters a change where the workers begin to build queen cells. Once the workers start building on the queen cells, no more worker cells are built, but those that still have brood growing in them are retained. The majority of the food resource brought in by the workers is fed to the queen larvae, known as gynes and the lack of feeding for other larvae causes the prolongation of their larval periods.
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It has been suggested that this feature was once more widespread. Paleolithic Venus figurines, sometimes referred to as "Steatopygian Venus" figures, discovered from Europe to Asia presenting a remarkable development of the thighs, and even the prolongation of the labia minora, have been used to support this theory. Whether these were intended to be lifelike or exaggeratory, even idealistic, is unclear. These figures however do not qualify as steatopygian, since they exhibit an angle of approximately 120 degrees between the back and the buttocks, while steatopygia is diagnosed by modern medical standards at an angle of about 90 degrees only.
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He also expressed the hope that the new British foreign secretary Philip Hammond "will adopt a constructive diplomacy" towards Iran. Several sources reported that all parties were prepared to extend negotiations but extension faced opposition in the United States Congress. Republicans and Democrats in Congress made it clear that they view a prolongation of the talks as allowing Iran to play for time. The Republican chairman of the United States House Committee on Foreign Affairs Ed Royce said he hoped "the administration will finally engage in robust discussions with Congress about preparing additional sanctions against Iran".
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Neolithic clay amulet (retouched), part of the Tărtăria tablets set, dated to 5500-5300 BC and associated with the Turdaş-Vinča culture. The Vinča symbols on it predate the proto-Sumerian pictographic script. Discovered in 1961 at Tărtăria, Alba County, Romania by the archaeologist Nicolae Vlassa. The Starčevo-Criş culture, representing the generalisation of the early Neolithic in the Intra-Carpathian territory, has been regarded by some as the prolongation of the Gura Baciului-Cârcea/Precriş culture, disregarding that it is probably the result of a new south Balkan migration (the Presesklo culture) arriving in Transylvania via Banat.
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Global Nonviolent Action Database. Retrieved 8 July 2013. On May 8, 1999 Berríos began camping inside the U.S. Navy bombing practice grounds in the island of Vieques, Puerto Rico (see Navy-Vieques protests). He stayed in the Gilberto Concepción de Gracia encampment — baptized in honor of the PIP founder — for 362 consecutive days, enduring both camp devastations due to storms and declining health due to a new diagnosis of prostate cancer. On December 1999, he resigned his Senate seat due to the uncertainty and prolongation of his stay at the encampment, during which he continued drawing his salary as a senator.
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IL-2 cannot accomplish its role as a promising immunotherapeutic agent due to significant drawbacks which are listed above. Some of the issues can be overcome using IL-2 ic. They are composed of IL-2 and some of its monoclonal antibody (mAb) and can potentiate biologic activity of IL-2 in vivo. The main mechanism of this phenomenon in vivo is due to the prolongation of the cytokine half-life in circulation. Depending on the clone of IL-2 mAb, IL-2 ic can selectively stimulate either CD25high (IL-2/JES6-1 complexes), or CD122high cells (IL-2/S4B6).
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Mutations in the gene can lead to a defective protein and several forms of inherited arrhythmias as Long QT syndrome which is a prolongation of the QT interval of heart repolarization, Short QT syndrome, and Familial Atrial Fibrillation. KvLQT1 are also expressed in the pancreas, and KvLQT1 Long QT syndrome patients has been shown to have hyperinsulinemic hypoglycaemia following an oral glucose load. Currents arising from Kv7.1 in over-expression systems have never been recapitulated in native tissues - Kv7.1 is always found in native tissues with a modulatory subunit. In cardiac tissue, these subunits comprise KCNE1 and yotiao.
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The regiments immediately demonstrated savoir-faire in managing controlled riots and croud dispersions to the point of effect where the mission became a pivot prolongation to maintain status for a long term peace. The beginning of the years 2000 witnessed a recurring engagement of the rapaces (paratroopers of the 1er RCP) on the African soil around Tchad, Gabon and Central African Republic. However, the most marking one would be the Ivory Coast. At the end of 2002, a battalion of the 1er RCP prepositioned in Gabon, was projected in urgency to Abidjan in order to participate in the exiting of French citizens.
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These include anaphylaxis, hepatotoxicity, central nervous system effects including seizures and psychiatric effects, prolongation of the QT interval, blood glucose disturbances, and photosensitivity, among others. Levofloxacin may produce fewer of these rare serious adverse effects than other fluoroquinolones. There is some disagreement in the medical literature regarding whether and to what extent levofloxacin and other fluoroquinolones produce serious adverse effects more frequently than other broad spectrum antibacterial drugs. With regard to more usual adverse effects, in pooled results from 7537 patients exposed to levofloxacin in 29 clinical trials, 4.3% discontinued treatment due to adverse drug reactions.
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TDBBB can be diagnosed with use of an electrocardiogram (ECG) which will "trace" the electrical activity of the heart, providing an overall view of the hearts electrical system. Typically, TDBBB will be evident on an ECG and manifest as a prolongation of the QRS complex (a QRS complex completion time that exceeds 120ms), notching or slurring of the R wave, or the absence of Q waves should the TDBBB affect the left ventricle.Kumar V, Venkataraman R, Aljaroudi W, Osorio J, Heo J, Iskandrian AE, Hage FG. "Implications of Left Bundle Branch Block in Patient Treatment", Am J Cardiol 2013;111:291-300.
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In 1890, at the age of 70, he published On the Prolongation of Life, which reached a second edition. In 1870–71 Dudgeon wrote notes on the Dioptrics of Vision (1871), and invented spectacles for use under water, intended to correct refraction. Original but unaccepted views which he held on the accommodation of the eye, and described to the International Medical Congress, were published in The Human Eye: its Optical Construction popularly explained (1878). In 1878 he obtained a Pond's sphygmograph, and with the help of J. Gauter he made a pocket instrument for registering the pulse.
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Torsades occurs as both an inherited (linked to at least 17 genes) and as an acquired form caused most often by drugs and/or electrolyte disorders that cause excessive lengthening of the QT interval. Common causes for torsades de pointes include drug-induced QT prolongation and less often diarrhea, low serum magnesium, and low serum potassium or congenital long QT syndrome. It can be seen in malnourished individuals and chronic alcoholics, due to a deficiency in potassium and/or magnesium. Certain drugs and combinations of drugs resulting in drug interactions are common contributors to torsades de pointes risk.
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Roger Bacon, a Franciscan friar who wrote on a wide variety of topics including optics, comparative linguistics, and medicine, composed his Great Work () for as part of a project towards rebuilding the medieval university curriculum to include the new learning of his time. While alchemy was not more important to him than other sciences and he did not produce allegorical works on the topic, he did consider it and astrology to be important parts of both natural philosophy and theology and his contributions advanced alchemy's connections to soteriology and Christian theology. Bacon's writings integrated morality, salvation, alchemy, and the prolongation of life.
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The New Abbasid Style (NS) began at the end of the 9th century C.E. and was used for copying the Quran until the 12th centuries, and maybe even as late as the 13th century. Unlike manuscripts copied in Early Abbasid scripts, NS manuscripts had vertical formats. During this time, Al-Khalil ibn Ahmad al- Farahidi (died 786) devised a tashkil system to replace that of Abu al-Aswad. His system has been universally used since the early 11th century, and includes six diacritical marks: fatha (a), damma (u), kasra (i), sukun (vowel- less), shadda (double consonant), madda (vowel prolongation; applied to the alif).
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Grimmer Parish is defined in the Territorial Division Act as being bounded: :Southerly by the southern boundary line of lot number twenty-five, granted to Paul Berube, in Range 6, Rang-Double-Sud,Stewart Settlement. and the prolongation of said boundary line easterly to the Parish of Eldon, and westerly to a point on the bank or shore of the Restigouche River. West by a straight line drawn due north astronomically from the said last-mentioned point to the southern boundary line of the Province of Quebec. Northerly by said Province and easterly by the Parish of Eldon.
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A 2008 British Medical Journal article highlights that the combination of some macrolides and statins (used for lowering cholesterol) is not advisable and can lead to debilitating myopathy. This is because some macrolides (clarithromycin and erythromycin, not azithromycin) are potent inhibitors of the cytochrome P450 system, particularly of CYP3A4. Macrolides, mainly erythromycin and clarithromycin, also have a class effect of QT prolongation, which can lead to torsades de pointes. Macrolides exhibit enterohepatic recycling; that is, the drug is absorbed in the gut and sent to the liver, only to be excreted into the duodenum in bile from the liver.
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Nonpharmacological treatments involve different interventions, starting with sleep hygiene, which includes sleep promoting activities such as maintaining a regular and strict sleep schedule and avoiding heavy meals before bedtime in order to restore the natural sleep-wake cycle. Further treatments options are phototherapy and infrared light therapy, which both, aim to treat circadian rhythm disorders such as delayed sleep phase disorder. Especially in patients with hypersomnia, bright light therapy in the morning has been proven to be effective. A prolongation of slow-wave sleep increases glymphatic clearance of metabolic waste products, which can lead to improvements of sleep disorders.
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International consensus guidelines differ on the degree of QT prolongation required to diagnose LQTS. The European Society of Cardiology recommends that, with or without symptoms or other investigations, LQTS can be diagnosed if the corrected QT interval is longer than 480ms. They recommend that a diagnosis can be considered in the presence of a QTc of greater than 460 ms if unexplained syncope has occurred. The Heart Rhythm Society guidelines are more stringent, recommending QTc cutoff of greater than 500 ms in the absence of other factors that prolong the QT, or greater than 480 ms with syncope.
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He was Man of the Match in the final as he was involved in all three of CSKA's goals. He scored in the 3–1 UEFA Super Cup lost to then European Champions Liverpool, but despite this defeat, Carvalho had shown he could cope on the European stage. In November 2007, Carvalho signed a new contract with CSKA until summer 2010, according to CSKA president Yevgeni Giner (or until December 2009, according to CSKA Press Office), with the option of further prolongation and the minimum fee release clause. However, he went on a six-month loan back to SC Internacional in July 2008.
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A fourth treaty, the Treaty between the Government of Australia and the Government of the Republic of Indonesia establishing an Exclusive Economic Zone Boundary and Certain Seabed BoundariesFull text available in the Australian Treaty Series website (informally known as the Australia–Indonesia Maritime Delimitation Treaty) which was signed in Perth on 14 March 1997 (however not ratified), proposes to extended the western segment of the seabed boundary to its termination point in the Indian Ocean. The basis for establishing the boundary in the 1971 and 1972 treaties was that of the "natural prolongation" of the physical continental shelf.
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On a positive note, Kidd moved rising 21-year old Giannis Antetokounmpo into a point guard position, which helped the young player to record five triple doubles in the season and make progress in most statistical categories. Despite the disappointing season, the Bucks owners issued Kidd a vote of confidence and mentioned a possible prolongation of his contract expiring after the next season. The following season Kidd led the Bucks to a winning record as they qualified to the playoffs for the second time in three years. Kidd had his projected starting unit available for just several minutes during the season.
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1974 Jun;112(6):2055–62 Mechnikov's early observation, then, was the foundation for studies that defined a critical mechanism by which bacteria attract leukocytes to initiate and direct the innate immune response of acute inflammation to sites of host invasion by pathogens. Mechnikov also developed a theory that aging is caused by toxic bacteria in the gut and that lactic acid could prolong life. Based on this theory, he drank sour milk every day. He wrote The Prolongation of Life: Optimistic Studies, in which he espoused the potential life-lengthening properties of lactic acid bacteria (Lactobacillus delbrueckii subsp. bulgaricus).
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Research into the use of ketamine to treat MDD had already determined that the drug could have effectiveness in rapidly reducing the symptoms of depression. Unfortunately ketamine has powerful dissociative effects, leaving patients in a trance-like state after administration and lending itself to recreational abuse. In 2008 a proof of concept study was conducted by Pfizer using the NR2B antagonist traxoprodil, which proved that drugs similar to ketamine could be used to treat depressive symptoms without causing the dissociative effect seen in that drug. Traxoprodil was eventually dropped from development due to bioavailability issues and the possibility of it causing QT prolongation.
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An old theory envisaged that Lake Ballivián or some other precursor of Lake Titicaca originally was a northwestern prolongation of the Rio La Paz valley before gravelly deposits dammed it, or of a Pacific-draining valley which was blocked by volcanic activity. Lake Ballivián is of late Quaternary age, it may have formed between 600,000 - 500,000 years ago. Such a dating is supported by fossils found in sediments left by the lake. The existence of Lake Ballivián in the Titicaca basin may coincide with the existence of Lake Escara, and preceded the existence of Lake Minchin.
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A fourth treaty, the Treaty between the Government of Australia and the Government of the Republic of Indonesia establishing an Exclusive Economic Zone Boundary and Certain Seabed BoundariesFull text available in the Australian Treaty Series website (informally known as the Australia–Indonesia Maritime Delimitation Treaty) which was signed in Perth on 14 March 1997 (however not ratified), proposes to extended the western segment of the seabed boundary to its termination point in the Indian Ocean. The basis for establishing the boundary in the 1971 and 1972 treaties was that of the "natural prolongation" of the physical continental shelf.
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Geomorphologically the Galician Massif is a northwestern prolongation of the Meseta Central, the inner Iberian plateau and has great affinity with the geology of the Tras os Montes Portuguese region, so that it is considered as a whole under the name 'Galicia-Trás-os-Montes Zone'.Silurian graptolite biostratigraphy of the Galicia - Tras-os-Montes Zone (Spain and Portugal) It is composed of Paleozoic materials (granite) with metamorphic rocks such as gneiss, slate and schist in the center and west, which were subject to Alpine folding. Its eastern end merges with the Cantabrian Mountains.Wes Gibbons & Teresa Moreno, The geology of Spain.
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A variety of neurological problems such as paralysis of half of the body, complete inflammation of a whole horizontal section of spinal cord, and muscle weakness due to immune damage of the nerves supplying the muscles are the complications. Signs of bleeding such as non- traumatic bruises at , non-traumatic bruises more than , nose bleeding, blackish stools due to bleeding in the stomach, vomiting blood and bleeding from the lungs can also be found. Prolongation of prothrombin time in coagulation testing is associated with severe bleeding manifestation. However, low platelet count is not associated with severe bleeding.
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The prolongation of the action potential and its subsequent positive inotropic effect can be influenced by stimulus frequency; at higher frequencies (1 Hz), the effects of GPT were suppressed. Furthermore, the effects of GPT on the sodium channels depend on the membrane potential of the cell preceding GPT binding, suggesting that the effects of GPT are potential-dependent. Also, in the presence of GPT, sodium channels are activated in response to an unusually small depolarizing stimulus. The 19 kDa GPT stimulates Ca influx and its activity can be prevented in the presence of a calcium channel blocker.
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Due to their losses in and after the Battle of Warsaw, the Soviets offered the Polish peace delegation substantial territorial concessions in the contested borderland areas, closely resembling the border between the Russian Empire and the Polish–Lithuanian Commonwealth before the first partition of Poland in 1772. Polish resources were exhausted, however, and Polish public opinion was opposed to a prolongation of the war. The Polish Government was also pressured by the League of Nations, and the negotiations were controlled by Dmowski's National Democrats. National Democrats cared little for Piłsudski's vision of reviving Międzymorze, the multi-cultural Polish–Lithuanian Commonwealth.
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Tendon damage may manifest during, as well as up to a year after fluoroquinolone therapy has been completed. FQs prolong the QT interval by blocking voltage-gated potassium channels. Prolongation of the QT interval can lead to torsades de pointes, a life-threatening arrhythmia, but in practice this appears relatively uncommon in part because the most widely prescribed fluoroquinolones (ciprofloxacin and levofloxacin) only minimally prolong the QT interval. Clostridium difficile-associated diarrhea may occur in connection with the use of any antibacterial drug, especially those with a broad spectrum of activity such as clindamycin, cephalosporins, and fluoroquinolones.
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Prolongation and fertility of both society and race is the subject, and it is treated with a gentility of spirit. The ground surface-to-roof piece The Unfilled Book—The Book of Mankind that Shengzhong finished at UAlbany contains several books at top side tallness, holding 900 pages that have been sliced to free and suspend portions of textless paper. Every coterminous line from every page joins similar to an umbilical line to small red individuals that splay out in the deck. This piece strongly sets aside doctrine and confirms the imperativeness of the individuals, and is the standout of the show.
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181 and Whittall 1999, p.27. #"as a quasi-tonal procedure" ["hierarchies analogous to (but distinct from) the traditional western tonal system."] #"as an attempt to transfer serial processes to electronic music" #"as a 'prolongation' of the initial inharmonic series" #"'as different perspectives on an object that is always present'" per Michael Clarke According to Curtis Roads, "Three compositions produced in the 1980s stand as good examples of compositional manipulation of analysis data: Mortuos Plango, Vivos Voco (1981) by Jonathan Harvey, Désintegrations (1983, Salabert Trajectoires) by Tristan Murail, and Digital Moonscapes (1985, CBS/Sony) by Wendy Carlos."Roads, Curtis (1996).
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The flexor hallucis brevis is located just inferior to the foot and toe bones. As its name suggests, its contraction results in flexion of the big toe (hallux). It arises, by a pointed tendinous process, from the medial part of the under surface of the cuboid bone, from the contiguous portion of the third cuneiform, and from the prolongation of the tendon of the Tibialis posterior which is attached to that bone. It divides in front into two portions, which are inserted into the medial and lateral sides of the base of the first phalanx of the great toe, a sesamoid bone being present in each tendon at its insertion.
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While nineteenth century's Neo-Humanism, Classicism and Olympism assumed the ancient roots of sport, body cultural studies showed that the patterns central to modern sports – quantification, rationalisation, principle of achievement – could not be dated before the industrial culture of the eighteenth and nineteenth centuries (Eichberg 1978; Guttmann 1978). What was practiced before, were popular games, noble exercises, festivities of different character, children's games and competitions, but not sport in modern understanding. The emergence of modern sport was an eruptive innovation rather than a logical prolongation of earlier practices. As a revolution of body culture, this transformation contributed to a deeper understanding of the Industrial Revolution.
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The Jbel Saghro is an eastern prolongation of the Anti-Atlas, separated from it by the valley of the Draâ. To the north of the range runs the valley of the Dadès, separating it from the massive High Atlas Range. Saɣru in the Tamazight language means drought, an apt name considering that the Jbel Saghro is the driest mountain area of the whole Atlas Mountain System. Since it is located in the inland side of the greater range this massif does not benefit from the Atlantic Ocean winds that bring humidity to the Anti-Atlas ranges further to the west as well as other ocean-facing ranges further north.
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Schenker intended his theory to apply only to music of the common practice period, and there to a select class of mostly Austro-German composers in a line from J.S. Bach to Johannes Brahms. Developments in more recent music theory have sought to clarify the conditions under which prolongation may obtain, so that other repertoires may either be opened up or more justifiably be precluded. Schenker pupil Felix Salzer, for example, detects the rudiments of prolongational horizontalization in music as early as 12th-century plainchant and argues that it is a musical principle that persists through post-tonal music as well, such as Paul Hindemith and Igor Stravinsky.Salzer, Felix (1962).
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An aerial view of Calicoan Island The Guiuan Marine Reserve extends along the western and southern coast of Guiuan Peninsula, the southernmost tip of Samar, located between Leyte Gulf and the Philippine Sea. It contains numerous islands and islets, such as the chain of Calicoan, Leleboon (Sulangan) and Candolu which form a prolongation of the peninsula. These islands are separated only by narrow shoals and appear to be part of the Guiuan peninsula from a distance. A prominent feature of the islands is the coral ridge covered in bushes and shrubs that runs from Guiuan to the southern tip of Candolu in Songi Point.
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Other side effects include motor impairment (ataxia), flushed skin, blurred vision at nearpoint owing to lack of accommodation (cycloplegia), abnormal sensitivity to bright light (photophobia), sedation, difficulty concentrating, short-term memory loss, visual disturbances, irregular breathing, dizziness, irritability, itchy skin, confusion, increased body temperature (in general, in the hands and/or feet), temporary erectile dysfunction, and excitability, and although it can be used to treat nausea, higher doses may cause vomiting. Diphenhydramine in overdose may occasionally result in QT prolongation. Some individuals experience an allergic reaction to diphenhydramine in the form of hives. Conditions such as restlessness or akathisia can worsen from increased levels of diphenhydramine, especially with recreational dosages.
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It then moves up by step into the C before descending down to the lower octave D-flat. This register change is clearly seen in both the “Streets of Laredo” and in the allegretto. Starting at the lower octave D-flat in the ballad, there is an initial upward skip of a fourth followed by a prolongation of the G-flat by a lower-neighbor, the F. Then the melody rises by step to the C before stepping down to the B-flat and eventually skipping to the G-flat. Finally, to cadence the tune, the melody steps up into the G-flat before returning to the final G-flat.
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Churchill was a staunch advocate of foreign intervention, declaring that Bolshevism must be "strangled in its cradle". He secured, from a divided and loosely organised Cabinet, intensification and prolongation of the British involvement beyond the wishes of any major group in Parliament or the nation—and in the face of the bitter hostility of the Labour Party. On 14 January 1919 Churchill circulated a Most urgent and secret memorandum to all commanders of British forces asking whether their forces would serve overseas and particularly in Russia, whether they would serve as strikebreakers and the soldiers' attitude to trade unions. A copy was leaked to and published in the Daily Herald.
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The bastion projects 7 m (23 ft) from the face of the wall, and is 10.36 m (34) ft in breadth on each side of the gateway. It is ornamented on the outside, with simple mouldings and simple plaster carvings, but on the inner face which forms the prolongation of the gateway itself, it rises abruptly without any plinth or mouldings, from the ground level. Two flights of steps, one on each side of the gateway, provide access to the top of the bastion and the wall. Each gateway was equipped with a thick wooden door of two leaves, (which were removed after the British annexation).
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Bobonong can be accessed from Francistown through Selibi Phikwe or from Gaborone via Palapye both routes are tarred and branch off from the Main North South Highway which runs from Ramokgwebana to Ramatlabama. It is a semi town with both traditional and modern housing structures with a reliable electricity supply as well as the standard ICT services including both land line and cellular services. As a Sub District headquarters it has a cross sectional community and is served well by bus services from Selibi Phikwe, Gaborone and other areas of Botswana. The Lepokole Hills, a western prolongation of the Matobo Hills in Zimbabwe, are located 15 km north of Bobonong.
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The final cadence is delayed for several bars before the material from the opening bar resurfaces as the movement's closing theme, accompanied by a tonic pedal over forte dominant chords. Felix Salzer says the following about this opening, "[It is] one of the most fascinating substitutions of the entire literature...The whole passage appears as a most imaginative prolongation of interruption, the post- interruption phrase starting with a B-Major chord boldly substituting for the tonic. In addition, this post-interruption phrase introduces a very interesting melodic parallelism in form of an augmentation of the end of the pre-interruption phrase one step higher."Salzer, Felix, Structural Hearing, p.
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Pennfield Parish's boundaries use both metes and bounds: on the north by a line running true west from the southernmost corner of Queens County; on the east by a line running true north from the mouth of the Pocologan River; on the west by a prolongation north and south of the western line of a 1000-acre grant straddling Lake Utopia and then along a line running through the Letang River and Letang Harbour; and on the south by the Bay of Fundy. The parish also includes any islands with two miles (3.2 kilometres) of the shore and The Wolves, a group of islands more than five miles (eight kilometres) offshore.
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While loss-of-function mutations in KCNE1 cause Long QT syndrome, gain-of-function KCNE1 mutations are associated with early-onset atrial fibrillation. A common KCNE1 polymorphism, S38G, is associated with altered predisposition to lone atrial fibrillation and postoperative atrial fibrillation. Atrial KCNE1 expression was downregulated in a porcine model of post-operative atrial fibrillation following lung lobectomy. Recently an analysis of 32 KCNE1 variants shows that putative/confirmed loss-of-function KCNE1 variants predispose to QT-prolongation, however the low ECG penetrance observed suggests they do not manifest clinically in the majority of individuals, aligning with the mild phenotype observed for JLNS2 patients.
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On July 15, 1767, the Oblin-Le Camus de Mézière consortium, which had already won the subdivision of the former Soissons hotel and future builder, for the benefit of Armand-Gaston Camus, the Hôtel de Beauvau and the Hôtel du Tillet street in the Rue des Saussaies, was awarded a house in the rue Coquilliere, at the corner of Rue de Grenelle Saint-Honore (now Rue Jean-Jacques Rousseau), in the prolongation of the old hotel of Soissons. The street has hosted many hotels, such as the Hôtel de Gigault Crisenoy which was occupied by the town hall of the 14th arrondissement from 1796 to 1803.
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It causes repetitive firing and prolongation of action potentials, particularly in the central nervous system of insects. The increase in signaling is what causes the intense pain from bullet ant stings. Poneratoxin is in an inactive state when stored in the ant venom reservoir due to the reservoir's acidic conditions, but it becomes toxic when activated via a multistep process. The combination of poneratoxin binding to a cell membrane (in order to act upon a voltage-gated sodium channel) and the movement from acidic conditions in the ant venom reservoir to basic conditions at the target site leads to poneratoxin undergoing a conformational change that activates it.
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In 1910, he rose in defense of the "popular faith" against the prevailing Anti-Catholicism of Slovene liberals and social democrats, and criticised the prolongation of the Kulturkampf in the Slovene Lands. In 1917, Prepeluh became the leader of the internal opposition against the main current of the Yugoslav Social Democratic Party, which continued to put the social question before the issue of national emancipation. In 1918, with the creation of the State of Slovenes, Croats and Serbs, Prepeluh rose to the leadership of the party. He was the leader of its right wing in a sharp confrontation against the left wing, represented by Dragotin Gustinčič, Anton Štebi and Rudolf Golouh.
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This system gradually dies out and leaves the surface smooth, only the row of infrasutural tubercles survives in an enlarged but depressed form. And springing from these some sinuous oblique and slightly irregular longitudinal puckerings appear on the body whorl, which is nearly bisected by the sharpish, slightly expressed, finely tubercled carina. This bisection of the body whorl arises from the great prolongation and tumidity of the base On this base, below the carina, are five narrow, equally parted, spiral threads, and two intra-umbilical ones, which are more contiguous. Besides this larger system of sculpture, the whole surface is covered with minute, oblique, irregular, and interrupted puckerings of the epidermis.
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Has a higher incidence of extrapyramidal side effects than the other atypical antipsychotics, but still less than that seen with typical antipsychotics. A trend was observed in a clinical trial comparing mosapramine with perospirone that favoured perospirone for producing less prominent extrapyramidal side effects than mosapramine although statistical significant was not reached. It may produce less QT interval prolongation than zotepine, as in one patient who had previously been on zotepine switching to perospirone corrected their prolonged QT interval. It also tended to produce less severe extrapyramidal side effects than haloperidol in a clinical trial comparing the two (although statistical significance was not reached).
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More than 50 million years ago the Táchira depression was a strait that connected Lake Maracaibo with the Orinoco basin. Today it separates the Tamá Massif, a prolongation of the Cordillera Oriental of the Colombian Andes, from the Cordillera de Mérida in the Venezuelan Andes. This gap between the Colombian and Venezuelan Andes is a product of orogenic movements in the Paleogene period that created major faults, raised blocks and formed rifts including the Táchira Depression. There are four faults with northwest-southeast trends aligned in echelon across the Tachira depression between Córdoba in Colombia to the west and Torondoy in Venezuela to the east.
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Cross-section of the head and neck Vocal resonation is the process by which the basic product of phonation is enhanced in timbre and/or intensity by the air-filled cavities through which it passes on its way to the outside air. Various terms related to the resonation process include amplification, enrichment, enlargement, improvement, intensification, and prolongation, although in strictly scientific usage acoustic authorities would question most of them. The main point to be drawn from these terms by a singer or speaker is that the end result of resonation is, or should be, to make a better sound. There are seven areas that may be listed as possible vocal resonators.
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The orifice of the aquæductus vestibuli is the hind part of the medial wall; it extends to the posterior surface of the petrous portion of the temporal bone. It transmits a small vein and contains a tubular prolongation of the membranous labyrinth, the endolymphatic duct, which ends in a cul-de- sac between the layers of the dura mater within the cranial cavity. On the upper wall or roof, there is a transversely oval depression, the recessus ellipticus, separated from the recessus sphæricus by the crista vestibuli already mentioned. The pyramid and adjoining part of the recessus ellipticus are perforated by a number of holes (macula cribrosa superior).
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At lower doses, the person may only experience a headache due to an increase in blood pressure. In response to these adverse effects, a different type of MAOI has been developed: the reversible inhibitor of monoamine oxidase A (RIMA) class of drugs. Their primary advantage is that they do not require the person to follow a special diet, while being purportedly effective as SSRIs and tricyclics in treating depressive disorders. Tricyclics and SSRI can cause the so-called drug-induced QT prolongation, especially in older adults; this condition can degenerate into a specific type of abnormal heart rhythm called torsades de points which can potentially lead to sudden cardiac arrest.
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Kingston Parish is defined in the Territorial Division Act as being bounded: :Northwest by Belleisle Bay and Long Reach; southwest by Westfield Parish; southeast by the Kennebecasis Bay and River until it meets the line dividing lots numbered twelve and thirteen in the Kingston grant; thence northerly along said line and easterly along the rear of the said grant to the line between the lots numbered thirty-three and thirty-four therein; thence northwesterly along the prolongation of said line to the Springfield Parish line; thence southwesterly and northerly along said Springfield Parish line to Belleisle Bay, including Long Island, in the Kennebecasis River.
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Type 2 Second-degree AV block, also known as Mobitz II, is almost always a disease of the distal conduction system (His-Purkinje System). Mobitz II heart block is characterized on a surface ECG by intermittently nonconducted P waves not preceded by PR prolongation and not followed by PR shortening. There is usually a fixed number of non-conducted P waves for every successfully conducted QRS complex, and this ratio is often specified in describing Mobitz II blocks. For example, Mobitz II block in which there are two P waves for every one QRS complex may be referred to as 2:1 Mobitz II block.
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Deportivo encountered the most problematic years of its existence after the relegation in 1973. The club found itself trapped between the Segunda B División and even the Tercera División and the relegation from the highest level left a tremendous mark on the social and sporting reputation of the club. This was stressed even more due to the constant rise in debt of the already economically troubled club. Not even Luis Suárez, as coach of Deportivo during the season 1978/1979, could turn the tide. The 1980s were a prolongation of the uncertainties and despair within La Coruña, and the everlasting obsession of returning to the Primera División grew each year.
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Rising from the shores of the Buor-Khaya Gulf in the north, it runs southwards spanning roughly 1000 km (600 mi.) across Yakutia, east of the Central Yakutian Lowland, and west of the Chersky Range, reaching the Lena Plateau to the south and the Yudoma-Maya Highlands to the southeast. It forms a vast arc between the Lena and Aldan rivers to the west and the Yana River to the east. Its highest point is an unnamed high peak in the middle section of the range. The Verkhoyansk Range has a higher southeastern prolongation, the Suntar-Khayata Range, that is occasionally considered as a separate range system.
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The first, or absolute, way the capitalist can increase surplus value is through the prolongation of the working day so the worker has more time to create value. The second, or relative, way the capitalist can increase surplus value is to revolutionize changes in the production method. If the worker can only produce the means for himself in the time he works during the day, there would be no extra time for him to create surplus value for the capitalist. The capitalist must then either enable the worker to complete the paid work time more quickly through relative means, or he must increase the work day in absolute terms.
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In 2013 the FDA issued a warning that azithromycin "can cause abnormal changes in the electrical activity of the heart that may lead to a potentially fatal irregular heart rhythm." The FDA noted in the warning a 2012 study that found the drug may increase the risk of death, especially in those with heart problems, compared with those on other antibiotics such as amoxicillin or no antibiotic. The warning indicated people with preexisting conditions are at particular risk, such as those with QT interval prolongation, low blood levels of potassium or magnesium, a slower than normal heart rate, or those who use certain drugs to treat abnormal heart rhythms.
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Sarir was discovered by geophysical methods and subsurface geology with no topographic or geomorphic anomalies being reported. An air magnetometer revealed the southwestern A structure and its southeastern prolongation, which was later found to be a buried fault line. Sarir is located on the northwest plunge of a gravity maximum axis and overshadowed by two western features: (1) a large gravity maximum, the A structure; (2) a strong gravity maximum, the B structure. The eastern feature, rising to a gravity maximum, is known as the C structure (Sarir C). Seismic reflection and refraction surveys (1960-1961) revealed that the C structure has a pronounced basement feature.
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Mutations in emerin cause X-linked recessive Emery–Dreifuss muscular dystrophy, which is characterized by early contractures in the Achilles tendons, elbows and post-cervical muscles; muscle weakness proximal in the upper limbs and distal in lower limbs; along with cardiac conduction defects that range from sinus bradycardia, PR prolongation to complete heart block. In these patients, immunostaining of emerin is lost in various tissues, including muscle, skin fibroblasts, and leukocytes, however diagnostic protocols involve mutational analysis rather than protein staining. In nearly all cases, mutations result in a complete deletion, or undetectable levels, of emerin protein. Approximately 20% of cases have X chromosomes with an inversion within the Xq28 region.
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Position: Falerii Novi - Porta di Giove The site of the Roman Falerii Novi is now entirely abandoned. It lay upon a road which may have been the Via Annia, a by-road of the Via Cassia; this road approached it from the south passing through Nepet, while its prolongation to the north certainly bore the name Via Amerina. The circuit of the city is about 2000 m, its shape roughly triangular, and the walls are a remarkably fine and well-preserved specimen of Roman military architecture. Falerii Novi - remains of the city wall The Roman town lay five kilometers farther north-west on the Via Annia.
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As per Regulation No 539/2001 (amended by Regulation No 1289/2013) reciprocity is required from all Annex II countries and territories. That means that these countries must offer visa-free access for 90 days to citizens of the 26 Schengen member states. When this is not the case, the affected Schengen member state is expected to notify the European Commission. Starting six months after the notification, the Commission may adopt an implementing act to suspend the visa-free regime for certain categories of nationals of the third country concerned, for a period of up to six months, with a possible prolongation by further periods of up to six months.
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Macron believes that the proposed reform bill on deprivation of citizenship for French-born and naturalized citizens convicted on terrorism charges was not a "concrete solution" and believes that "the endless prolongation of the state of emergency raises legitimate questions". He advocates an increase in state funding of intelligence agencies. Macron calls for a restoration of community policing and considers that "the management of some major risks must be delegated to the associations' or the private sector". He considers that his proposal to provide each young adult a "Culture Pass" of €500 may encourage young people to discover the culture of France and deter terrorism.
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It is crowned by a dome in the early style of S. Mario at Montepulciano. For the same patron, he constructed the Palazzo Montalto near Santa Maria Maggiore, with its skilful distribution of masses and tied decorative scheme of reliefs and festoons, impressive because of the dexterity with which the artist adapted the plan to the site at his disposal. After the cardinal's accession as Sixtus V, he appointed Fontana Architect Of St. Peter's, bestowing upon him, among other distinctions, the title of Knight of the Golden Spur. He added the lantern to the dome of St. Peter's and proposed the prolongation of the interior in a well-defined nave.
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Jamestown C. McKinney, a renowned vocal pedagogue and longtime professor of voice at Southwestern Baptist Theological Seminary's school of church music, defines vocal resonance as "the process by which the basic product of phonation is enhanced in timbre and/or intensity by the air-filled cavities through which it passes on its way to the outside air."McKinney, James (1994) The Diagnosis and Correction of Vocal Faults, Nashville, TN: Genovex Music Group. Throughout the vocal literature, various terms related to resonation are used, including: amplification, filtering, enrichment, enlargement, improvement, intensification, and prolongation. Acoustic authorities would question many of these terms from a strictly scientific perspective.
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The 1979–80 season was FC Dinamo București's 31st season in Divizia A. The change at the manager's level (Angelo Niculescu for Ion Nunweiller) didn't produce the desired results and Dinamo didn't matter in the fight for the title, ending far from the first two teams. Also, in the Romanian Cup Dinamo was eliminated in the first round, by the second division team Rapid București. In the UEFA Cup, Dinamo eliminated Alki Larnaca from Cyprus, after an incredible 9–0 away win, but is eliminated (partially because of the referee) by Eintracht Frankfurt, team of Pezzey, Grabowsky and Holzenbein (2-0 and 0–3 in prolongation).
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Vocal resonation is the process by which the basic product of phonation is enhanced in timbre and/or intensity by the air-filled cavities through which it passes on its way to the outside air. Various terms related to the resonation process include amplification, enrichment, enlargement, improvement, intensification, and prolongation; although in strictly scientific usage acoustic authorities would question most of them. The main point to be drawn from these terms by a singer or speaker is that the end result of resonation is, or should be, to make a better sound. There are seven areas that may be listed as possible vocal resonators.
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Initial successes were followed by infighting, which almost caused the Greek struggle to collapse; nevertheless, the prolongation of the fight forced the Great Powers (Britain, Russia and France) to recognize the claims of the Greek rebels to separate statehood (Treaty of London) and intervene against the Ottomans at the Battle of Navarino. Greece was initially to be an autonomous state under Ottoman suzerainty, but by 1832, in the Treaty of Constantinople, it was recognized as a fully independent kingdom. In the meantime, the 3rd National Assembly of the Greek insurgents called upon Ioannis Kapodistrias, a former foreign minister of Russia, to take over the governance of the fledgling state in 1827.
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From the 1987 election until its abolition, the riding included most of the District of Cochrane (except Timmins, the geographic townships bordering Timmins on the west, Iroquois Falls, and all the communities and townships south of a line extending east from the northern boundary of Iroquois Falls to Lake Abitibi and then all communities and townships south of Lake Abitibi). The riding also included the two geographic townships in Algoma District immediately south of Hearst and all of Kenora District east of the prolongation of the westerly border of Cochrane District. The riding was abolished in 1998 into Timmins—James Bay, Algoma—Manitoulin and Timiskaming—Cochrane. Prior to 1926, the riding was known as Cochrane.
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The tubercles are separated from each other by a deep groove, the bicipital groove (intertubercular groove), which lodges the long tendon of the biceps brachii muscle and transmits a branch of the anterior humeral circumflex artery to the shoulder-joint. It runs obliquely downward, and ends near the junction of the upper with the middle third of the bone. In the fresh state its upper part is covered with a thin layer of cartilage, lined by a prolongation of the synovial membrane of the shoulder-joint; its lower portion gives insertion to the tendon of the latissimus dorsi muscle. It is deep and narrow above, and becomes shallow and a little broader as it descends.
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Over 10% of oral sotalol users experience fatigue, dizziness, lightheadedness, headache, weakness, nausea, shortness of breath, bradycardia (slow heart rate), a sensation of the heart beating too hard, fast, or irregularly, or chest pain. Higher doses of sotalol increase the risk for all of these possible side effects. In rare cases, the QT prolongation caused by sotalol can lead to the development of life-threatening torsade de pointes (TdP) polymorphic ventricular tachycardia. Across several clinical trials, 0.6% of oral sotalol patients with supraventricular abnormal heart rhythms (such as atrial fibrillation) developed TdP. For patients who had a history of sustained ventricular tachycardia (abnormal rhythm lasting more than 30 seconds), 4% developed TdP.
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On 29 November 1917 Lansdowne's letter was published in The Daily Telegraph. It again called for a negotiated peace with Germany: > We are not going to lose this war, but its prolongation will spell ruin for > the civilised world, and an infinite addition to the load of human suffering > which already weighs upon it...We do not desire the annihilation of Germany > as a great power ... We do not seek to impose upon her people any form of > government other than that of their own choice... We have no desire to deny > Germany her place among the great commercial communities of the world. The letter also called for a guarantee of the 'freedom of the seas'.
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The normal range of QT intervals in the normal population and in those with Romano-Ward syndrome Characteristic T-wave patterns in the 3 major subtypes of Romano-Ward syndrome Romano–Ward syndrome is principally diagnosed by measuring the QT interval corrected for heart rate (QTc) on a 12-lead electrocardiogram (ECG). Romano–Ward syndrome is associated with a prolonged QTc, although in some genetically proven cases of Romano–Ward syndrome this prolongation can be hidden, known as concealed Long QT syndrome. The QTc is less than 450 ms in 95% of normal males, and less than 460 ms in 95% of normal females. Romano–Ward syndrome is suggested if the QTc is longer than these cutoffs.
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In 1980, following the return of democracy, the Madrid City Council voted to rename streets throughout the capital, reinstating those had prior to the Second Republic; these measures, passed with the votes of the PSOE and PCE municipal councillors, were opposed by the UCD councillors. The Santiago Bernabéu Stadium (Estadium the Chamartín) in the early 1950s La Castellana is prolongation of the Paseo de Recoletos and the Paseo del Prado, and these three avenues vertebrate the north-south axis of the city. The street starts at Plaza de Colón, ending at its junction with the M-30 ring road, the so- called Nudo Norte. It passes through the Plaza de Lima, Plaza de Cuzco and the Plaza de Castilla.
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Cartan's methods in the theory of differential systems are perhaps his most profound achievement. Breaking with tradition, he sought from the start to formulate and solve the problems in a completely invariant fashion, independent of any particular choice of variables and unknown functions. He thus was able for the first time to give a precise definition of what is a "general" solution of an arbitrary differential system. His next step was to try to determine all "singular" solutions as well, by a method of "prolongation" that consists in adjoining new unknowns and new equations to the given system in such a way that any singular solution of the original system becomes a general solution of the new system.
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In March 1922, the Allies proposed an armistice. Feeling that he now held the strategic advantage, Mustafa Kemal declined any settlement while the Greeks remained in Anatolia and intensified his efforts to re-organise the Turkish military for the final offensive against the Greeks. At the same time, the Greeks strengthened their defensive positions, but were increasingly demoralised by the inactivity of remaining on the defensive and the prolongation of the war. The Greek government was desperate to get some military support by the British or at least secure a loan, so it developed an ill-thought plan to force the British diplomatically, by threatening their positions in Constantinople, but this never materialised.
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Further, too much of the island's productive machinery had been destroyed in the early weeks of the uprising without a long-term plan or ability to replace it. Fédon relied on reinforcements that never materialised. As a result, notes the scholar Claudia Wright, he was unable to turn his rebellion into a revolution, "despite the duration and intensity" of it, remaining too "limited in scope" to do so. Cox, meanwhile, has argued that Fedon's inability to bring the struggle to a close ultimately worked against him, arguing that, while the original prolongation of the war had favoured him, it eventually enabled the British to re-arm and utilise external support while denying him his own.
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Pascoevale Farm, Oak Park Court, Oak Park. Heritage Victoria., and was bounded approximately by the Moonee Ponds Creek, Gaffney Street, Northumberland Road and the western prolongation of Boundary Road. There were two other lots to the east of Moonee Ponds Creek.Parish of Jika Jika in the County of Bourke c.1839-1850. He lived at his farmhouse and at his town-house in Collingwood between 1840 and 1855. Fawkner was very active in the development of the Port Phillip settlement, including its political life and he set out his views on participation and franchise in his document, Constitution and form of government, believed to have been written in the 1830’s : Tim Hogan. John Pascoe Fawkner Papers, 1832–71.
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In the run-up to the 2009 elections (presidential, Assembly, and municipal), a movement to draft President Tandja for a third term appeared. Led by public figures of the MNSD outside government, the group took the name of Tandja's 2004 re-election slogan, Tazartché: a Hausa word meaning "Continuity". Through several well funded and well attended public rallies in late 2008, the President remained silent on the calls for him to remain.Le Président Tandja reste muet sur les appels en faveur d’une prolongation de son mandat. APA 19 December 2008 The 1999 constitution not only limited the president to two terms (article 36), but explicitly barred amending this provision by any means (article 136).
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Between the nun's villa and the sanatorium, the tunnel was large enough to be used by employees during the hard winters when the temperature often drops below forty degrees. A steam turbine drove a direct current generator. In 1950, it was replaced by two alternative current generators with two diesel engines each (used alternatively) that also supplied the village until the prolongation of Hydro Québec's power lines in 1967-1968. In 1928, the Laurentian Forest Protective Association erected a steel tower (80 foot high for forest fire detection), built a telephone line along the railway and installed a free telephone at the sanatorium; the La Tuque Telephone company will supply phone service to the village in 1966.
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The first equation calculates the Hedberg Line, which is derived by adding 60 nautical miles to the foot of the slope of the natural prolongation. The second yields the Gardiner Line, which refers to the point at which the measurement of subsea sediment thickness is 1% of the distance back to the foot of the slope. The two formulae for deriving these values can be substituted in order to form a composite continental shelf for a coastal state that yields the most advantageous possible maritime territory extension. The United States has not ratified UNCLOS, although there is a concerted, bipartisan effort in Congress and among the various branches of the United States Military to do so.
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Fluoxetine can affect the electrical currents that heart muscle cells use to coordinate their contraction, specifically the potassium currents Ito and IKs that repolarise the cardiac action potential. Under certain circumstances, this can lead to prolongation of the QT interval, a measurement made on an electrocardiogram reflecting how long it takes for the heart to electrically recharge after each heartbeat. When fluoxetine is taken alongside other drugs that prolong the QT interval, or by those with a susceptibility to long QT syndrome, there is a small risk of potentially lethal abnormal heart rhythms such as Torsades de Pointes. As of 2019, the drug reference site CredibleMeds lists Fluoxetine as leading to a conditional risk of arrhythmias.
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Between 1982 and 1985, these artists exhibited on several occasions with their American counterparts: Keith Haring, Jean-Michel Basquiat, Kenny Scharf, Tseng Kwong Chi and inter alia, Crash (exhibitions in New York, London, Pittsburgh, and Paris). The Figuration Libre falls under the prolongation of artists and historical movements whose specificity was the opening to marginalized forms of expression, as the Cubism had opened with African art and Oceanic art (amongst other influences), and "art brut" with the children's drawings, Pop art with advertising and comic strips. Pierre et Gilles (Pierre Commoy and Gilles Blanchard), are gay French artistic and romantic partners. They produce highly stylized photographs, building their own sets and costumes as well as retouching the photographs.
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The tectorial membrane of atlanto-axial joint (occipitoaxial ligaments) is situated within the vertebral canal. D: Tectorial membrane of atlanto-axial joint It is a broad, strong band which covers the dens of the axis, and its ligaments, and appears to be a prolongation upward of the posterior longitudinal ligament of the vertebral column. It is fixed, below, to the posterior surface of the body of the axis, and, expanding as it ascends, is attached to the basilar groove of the occipital bone, in front of the foramen magnum, where it blends with the cranial dura mater. Its anterior surface is in relation with the transverse ligament of the atlas, and its posterior surface with the dura mater.
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Compartment syndrome is a clinical diagnosis, i.e., no diagnostic test conclusively proves its presence or absence, but direct measurement of the pressure in a fascial compartment, and the difference between this pressure and the blood pressure, may be used to assess its severity. High pressures in the compartment and a small difference between compartment pressure and blood pressure indicate that the blood supply is likely to be insufficient, and that surgical intervention may be needed. Disseminated intravascular coagulation, another complication of rhabdomyolysis and other forms of critical illness, may be suspected on the basis of unexpected bleeding or abnormalities in hematological tests, such as a decreasing platelet count or prolongation of the prothrombin time.
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Prenylamine (Segontin) is a calcium channel blocker of the amphetamine chemical class which was used as a vasodilator in the treatment of angina pectoris; it was introduced in the 1960s by German manufacturer Albert-Roussel pharma gmbh which was acquired by Hoechst AG in 1974 and which in turn became part of Sanofi Aventis in 2005. It was withdrawn from market worldwide in 1988 because it caused QT prolongation and Torsades de pointes which in turn caused sudden death. The cardiac side effects were not detected during clinical development, but only emerged after the drug was widely used. Prenylamine has two primary molecular target in human, Calmodulin and Myosin light-chain kinase 2 found in skeletal and cardiac muscle.
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CT (Clotting time): The CT is the latency time from adding the start reagent to blood until the clot starts to form. Prolongation of CT may be a result of coagulation deficiencies, primarily coagulation factors, or heparin (dependent on the test used). A potential contribution of heparin can be detected by comparing INTEM- with HEPTEM CT data (see “reagents” below). A shortening of CT indicates hypercoagulability. CFT (Clot formation time) and alpha-angle: The alpha angle is the angle of tangent between 0 mm and the curve when the clot firmness is 20 mm, while CFT is the time from CT until a clot firmness of 20 mm point has been reached.
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Cellular mechanisms leading to arrhythmias in long QT syndrome The various forms of long QT syndrome, both congenital and acquired, produce abnormal heart rhythms (arrhythmias) by influencing the electrical signals used to coordinate individual heart cells. The common theme is a prolongation of the cardiac action potential – the characteristic pattern of voltage changes across the cell membrane that occur with each heart beat. Heart cells when relaxed normally have fewer positively charged ions on the inner side of their cell membrane than on the outer side, referred to as the membrane being polarised. When heart cells contract, positively charged ions such as sodium and calcium enter the cell, equalising or reversing this polarity, or depolarising the cell.
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Although loading doses of warfarin over 5 mg also produce a precipitous decline in factor VII, resulting in an initial prolongation of the INR, full antithrombotic effect does not take place until significant reduction in factor II occurs days later. The haemostasis system becomes temporarily biased towards thrombus formation, leading to a prothrombotic state. Thus, when warfarin is loaded rapidly at greater than 5 mg per day, it is beneficial to co-administer heparin, an anticoagulant that acts upon antithrombin and helps reduce the risk of thrombosis, with warfarin therapy for four to five days, in order to have the benefit of anticoagulation from heparin until the full effect of warfarin has been achieved.
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The drug was authorized under the EUA as an experimental treatment for emergency use in hospitalized patients. On 9April, the National Institutes of Health began the first clinical trial to assess whether hydroxychloroquine is safe and effective to treat COVID‑19. On 24 April, the FDA cautioned against using the drug outside a hospital setting or clinical trial after reviewing case reports of adverse effects including ventricular tachycardia, ventricular fibrillation and in some cases death. According to Johns Hopkins' ABX Guide for COVID‑19, "Hydroxychloroquine may cause prolonged QT, and caution should be used in critically ill COVID‑19 patients who may have cardiac dysfunction or if combined with other drugs that cause QT prolongation".
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Smith, p. 337. After initially supporting it, he also came to think the suspension of habeas corpus in 1817 unnecessary after visiting the West Riding: "I was led to think nothing beyond ordinary powers [of the law] was called for...and therefore (whatever I might have thought before) that the prolongation of the suspension was not then necessary". In May that year intelligence of a planned uprising for June in the manufacturing areas of Lancashire, Yorkshire, Derbyshire and Nottinghamshire was acquired by the authorities and its leaders were arrested. A meeting of delegates planned three days before the uprising was due to start was intercepted by the yeomanry, who arrested the eleven who turned up.
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A bundle branch block can be diagnosed when the duration of the QRS complex on the ECG exceeds 120 ms. A right bundle branch block typically causes prolongation of the last part of the QRS complex and may shift the heart's electrical axis slightly to the right. The ECG will show a terminal R wave in lead V1 and a slurred S wave in lead I. Left bundle branch block widens the entire QRS, and in most cases shifts the heart's electrical axis to the left. The ECG will show a QS or rS complex in lead V1 and a monophasic R wave in lead I. Another normal finding with bundle branch block is appropriate T wave discordance.
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This includes a slowing of the sodium-channel inactivation, a hyperpolarizing shift in the voltage-dependence of activation and a hyperpolarizing shift in the steady-state sodium-channel inactivation. d-ACTX- Ar1a causes a prolongation of action potential duration, accompanied by spontaneous repetitive firing, but does not depolarize the resting membrane potential. Effects on the autonomic nervous system, including vomiting, profuse sweating, salivation, lachrymation, marked hypertension followed by hypotension, together with effect on the somatic nervous system to cause muscle fasciculation and dyspnea (shortness of breath) are presumably due to excessive transmitter release. To identify the sodium-channel binding surface of d-ACTX-Ar1a, scientist must synthesize analogues with selected residue changes.
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The opposition supported the change, but it was conscious of the case of Côte d'Ivoire's continuously postponed election and wanted the change to be accompanied by a political agreement.Centrafrique: l'Assemblée nationale examine la prolongation du mandat présidentiel Les Dépêches de Brazzaville, 3 May 2010 The constitutional change was overwhelmingly approved by the National Assembly in a vote on 10 May 2010; 95 deputies voted in favor, six voted against, and one abstained.C.African parliament votes to extend president's term AFP, 10 May 2010 An estimated 30,000 to 50,000 people marched in Bangui on 19 May 2010 to express support for the move to extend Bozizé's term. In their slogans, they equated support for Bozizé with support for peace.
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The physician had to be able to offer advice to the healthy as well as to the sick about how to live according to nature, for being in harmony with nature would result in the preservation of health as well as the prolongation of life. Thus "medicine" and "physic," as used in the late 15th century, are terms that suggest the differences between major traditions in the healing arts: one based upon experience, the other upon learning; one concerned primarily with healing, the other primarily with the preservation of health. Drohobych's appointment to King Casimir's court is an indication that he succeeded in both healing fields, because such an important position required extraordinary knowledge of philosophy and natural philosophy as well as practical experience in curing illnesses.
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" It begins with the narration: "The Messenger of Allah peace and blessings be upon him said: One who was devoted to the Qur'an will be told to recite, ascend and recite carefully () as he recited carefully when he was in the world, for he will reach his abode when he comes to the last verse he recites (Sunan Abi Dawud 1464)." This narration describes the importance of the manner of recitation and its positive effects in the afterlife. The next narration describes the importance of prolongation (): "Qatadah said: I asked Anas about the recitation of the Qur'an by the Prophet, peace and blessings be upon him. He said: He used to express all the long accents clearly () (Sunan Abi Dawud 1465).
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CR3 belongs to a family of cell surface receptors known as integrins (because they share this particular β chain, they are referred to as β2-integrins), which are extremely widely distributed throughout nature and which generally are important in cellular adhesion, migration, phagocytosis and other cell-cell interactions in a variety of cells and circumstances. Upregulation of Mac-1 in the presence of certain factors such as IL-2 may cause a prolongation of the life of the immune cell while the presence of TNF-α induces apoptosis and selective removal of the cell. A fully activated neutrophil may express on its membrane 200,000 or more CR3 molecules. Absence of CR3 results in reduced binding and ingestion of Mycobacterium tuberculosis in mice.
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Despite the position of military superiority in which the Sienese army found itself after the field victory, which would have seen them favored in a possible direct attack on Massa, it was decided by the Siena government to accept the proposed truce. In fact, the prolongation of the state of war was considered positive, so as to weaken the enemy further. Following new requests for help sent to Pisa, an army of 800 knights arrived in Maremma led by the exiled Florentine Ciupo Scolari, with the captains Roberto dalla Rocca, Piero delle Statere, Cellino dal Colle and Benedetto Maccaione dei Gualandi, in support of the cause Massetana. After initially attempting to besiege Paganico the captain directed his troops into the Sienese territory, burning and looting the countryside.
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1-22, 117) This led him to seek the key to an understanding of music in the traditional disciplines of counterpoint and figured bass, which was central to the compositional training of these composers. Schenker's project was to show that free composition (freier Satz) was an elaboration, a "prolongation", of strict composition (strenger Satz), by which he meant species counterpoint, particularly two- voice counterpoint. He did this by developing a theory of hierarchically organized levels of elaboration (Auskomponierung), called prolongational levels, voice–leading levels (Stimmführungsschichten), or transformations (Verwandlungen), the idea being that each of the successive levels represents a new freedom taken with respect to the rules of strict composition.See Schenker's "instructional plan" described in his Introduction to Free Composition, pp. xxi–xxii.
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It was hypothesized that the prolongation in PFS observed with tasquinimod treatment may lead to a survival advantage in men with metastatic CRPC. Also, a stronger trend for survival benefit was seen in patients with bone metastases; 34.2 for the tasquinimod group vs 27.1 months for the placebo group (HR 0.73, 95% CI 0.46, 1.17, p=0.19). Analysis of up to 3 years of safety data from phase II studies showed that treatment-related adverse events were mild to moderate, manageable and less frequent after 2 months of therapy. Adverse events observed included gastrointestinal disorders, fatigue, musculoskeletal pain as well as elevations of some laboratory parameters. A phase III randomized controlled trial called 10TASQ10 to confirm tasquinimod’s effect on disease progression is ongoing.
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The Certificate of a Pharmaceutical Product is needed by the importing country when the product in question is intended for registration (licensing, authorisation) or renewal (prolongation) of registration, with the scope of commercialisation or distribution in that country. Certification has been recommended by WHO to help undersized drug regulatory authorities or drug regulatory authorities without proper quality assurance facilities in importing countries to assess the quality of pharmaceutical products as prerequisite of registration or importation. In the presence of such CPP, WHO recommends to national authorities to ensure that analytical methods can be confirmed by the national laboratory, to review and if necessary to adapt product information as per local labelling requirements, and to assess bioequivalence and stability data if necessary.World Health Organization.
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The shape of the telson in O. kokomoensis was clavate (resembling a club), in O. pumilus it was styliform (pen-shaped) and in O. augusti it was lanceolate (lance-shaped). The walking legs (second to fifth pair of appendages or limbs) were generally undifferentiated, long, narrow and without spines except in the distal end. The swimming legs (sixth pair of appendages) were inconspicuous, very narrow and ending in a very long spike- like ninth podomere (leg segment). The swimming legs of O. augusti were easily recognizable from the other species by the prolongation of the eighth podomere into two lateral projections (parts of the body that protrude) and by the curved shape and great length of the spike-like podomere.
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Blood shift is a term used when blood flow to the extremities is redistributed to the head and torso during a breath-hold dive. Peripheral vasoconstriction occurs during submersion by resistance vessels limiting blood flow to muscles, skin, and viscera, regions which are "hypoxia-tolerant", thereby preserving oxygenated blood for the heart, lungs, and brain. The increased resistance to peripheral blood flow raises the blood pressure, which is compensated by bradycardia, conditions which are accentuated by cold water. Aquatic mammals have blood volume that is some three times larger per mass than in humans, a difference augmented by considerably more oxygen bound to hemoglobin and myoglobin of diving mammals, enabling prolongation of submersion after capillary blood flow in peripheral organs is minimized.
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Begun in 1831 in the prolongation of the rue des Saints-PèresThe name is a deformation of rue de Saint Pierre. on the Left Bank, the original bridge was known under that name until its inauguration, in 1834, when king Louis-Philippe named it Pont du Carrousel, because it opened on the Right Bank river frontage of the Palais du Louvre near the Arc de Triomphe du Carrousel in front of the Tuileries. The bridge's architect, Antoine-Rémy Polonceau, succeeded in a design that was innovative in several aspects. For one thing, the new structure was an arch bridge, during a period when most bridge construction had turned to suspension bridges; the necessary towers and cables would have been considered unacceptable additions to the Parisian scenery.
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The rubrics and calendar of the Mass and the Divine Office were reformed by the constitution Cum hac nostra aetate (March 23, 1955). The reform to the calendar, the most dramatic before its complete overhaul in 1969, consisted mainly in the abolition of various octaves and vigils. An octave is the week-long prolongation of a great feast, either by the celebration of a proper Mass all through the Octave or by the addition of an additional Collect when the Mass of another feast is celebrated. Of the 18 octaves existing in the Roman calendar, all but three (Easter, Pentecost, Christmas) were purged in the reform, including the octaves of the Epiphany, Corpus Christi, the Ascension and the Immaculate Conception.
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It is a sign of the maturity of our > relationship now that that is accepted as the UK's position. The British Government has ruled out the independence of Gibraltar because, according to the British view, under the Treaty of Utrecht it would require Spanish consent,Statement in the House of Commons by The Secretary of State for Foreign and Commonwealth Affairs, Mr. Jack Straw, 27 March 2006 and has ruled out Gibraltar's integration into the United Kingdom. The option of integration was rejected on 26 June 1976, when the British Government issued the Hattersley Memorandum ruling out integration in order to "avoid innovations which might result in prolongation of the frontier restrictions imposed by Spain."Written answer of Mr. Hattersley to Mrs.
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Some 160 years after Homeopathy and Its > Kindred Delusions, an essay by Oliver Wendell Holmes, we are still debating > whether homeopathy is a placebo or not... Homeopathic principles are bold > conjectures. There has been no spectacular corroboration of any of its > founding principles... After more than 200 years, we are still waiting for > homeopathy "heretics" to be proved right, during which time the advances in > our understanding of disease, progress in therapeutics and surgery, and > prolongation of the length and quality of life by so-called allopaths have > been breathtaking. The true skeptic therefore takes pride in closed > mindedness when presented with absurd assertions that contravene the laws of > thermodynamics or deny progress in all branches of physics, chemistry, > physiology, and medicine.
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Right elevation and plan as depicted in Brassey's Naval Annual 1888 She was similar in design to , but unlike her carried a revolving turret similar to that carried in . For reasons not recorded, it would appear that the belief prevalent at the time of the design of Hotspur that a ramming attack would damage the turret mechanism no longer held sway when Rupert was proposed. As was Hotspur, she was designed at a time, shortly after the 1866 battle of Lissa, when it was believed that ramming attacks would, in the event of naval conflict, be the most effective form of offensive action. Artillery power was therefore given second priority to handiness and to frontal armour, including a prolongation of the belt armour to reinforce the ram.
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The synovial membrane of the carpus is very extensive, and bounds a synovial cavity of very irregular shape. The upper portion of the cavity intervenes between the under surfaces of the navicular, lunate, and triangular bones and the upper surfaces of the bones of the second row. It sends two prolongations upward—between the navicular and lunate, and the lunate and triangular—and three prolongations downward between the four bones of the second row. The prolongation between the greater and lesser multangulars, or that between the lesser multangular and capitate, is, owing to the absence of the interosseous ligament, often continuous with the cavity of the carpometacarpal joints, sometimes of the second, third, fourth, and fifth metacarpal bones, sometimes of the second and third only.
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The other hypothesis is that a young republican killed in the "Three Glorious Days" of the July Revolution - cut down as he planted the tricolour - cried "Remember that I am called Arcole" just before his death, presumably as he was imitating Bonaparte's action. This account is reported in the English guide "Paris; Its Historical Buildings and Revolutions" (C. Cox, London 1849) It was only in 1828 that a suspension bridge for pedestrians with two 6m-wide carriageways, supported from a central pier in midstream, was built by Marc Seguin. In 1854, with increased traffic due to the prolongation of the rue de Rivoli, it was replaced by a more substantial metal structure that could also be used by vehicular traffic.
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The automatic curb sender was a kind of telegraph key, invented by William Thomson, 1st Baron Kelvin for sending messages on a submarine communications cable, as the well-known Wheatstone transmitter sends them on a land line. In both instruments, the signals are sent by means of a perforated ribbon of paper but the cable sender was the more complicated, because the cable signals are formed by both positive and negative currents, and not merely by a single current, whether positive or negative. Moreover, to curb the prolongation of the signals due to electromagnetic induction, each signal was made by two opposite currents in succession: a positive followed by a negative, or a negative followed by a positive. The aftercurrent had the effect of "curbing" its precursor.
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Putin also announced a list of measures of social protection, support for small and medium-sized enterprises, and changes in fiscal policy. Putin announced following measures for microenterprises, small- and medium-sized businesses: deferring tax payments (except Russia's value-added tax) for the next six months, cutting the size of social security contributions in half, deferring social security contributions, deferring loan repayments for the next six months, a six-month moratorium on fines, debt collection, and creditors' applications for bankruptcy of debtor enterprises. Additionally, a new tax on income from large deposits will be introduced in 2021, and the tax on offshores will be increased. On 2 April, Putin again issued an address in which he announced prolongation of the non-working time until 30 April.
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Djanet, and the nearby towns of Azelouaz, El Mihan, Adjahil and Eferi, lie in a valley carved by the intermittent river (wadi) Oued Idjeriou through the southwest edge of the Tassili n'Ajjer mountain range and east of the Erg Admer sand dunes. The Tadrart Rouge is located to the southeast and is a southern prolongation of the Libyan Tadrart Acacus. Due to the somewhat cooler air, higher humidity and somewhat higher rainfall in these areas, the nearby mountains support a greater amount and variety of wildlife than lower- lying areas in the Sahara, and forms part of the West Saharan montane xeric woodlands ecosystem. Djanet itself lies at an altitude of , but the mountains to the east and north reach as high as .
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Indirect studies in animal models suggest that EETs have protective effects in strokes (i.e. cerbrovasular accidents). Thus, sEH inhibitors and sEH-Gene knockout have been shown to reduce the damage to brain that occurs in several different models of ischemic stroke; this protective effect appears due to a reduction in systemic blood pressure and maintenance of blood flow to ischemic areas of the brain by arteriole dilation as a presumed consequence of inhibiting the degradation of EETs (and/or other fatty acid epoxides). sEH-gene knockout mice were also protected from that brain damage that followed induced-subarachnoid hemorrhage; this protective effect appeared due to a reduction in cerebral edema which was also presumable due to the prolongation of EET half-lives.
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During World War II (1942–44), there were basic cadets of the public Armed Forces Group Council in the Middle East, she participated with prolongation in Egypt, Syria, Palestine and Jordan. From 1944, she entered with her right to the theatrical company in Egypt, came into the Alexandria area. In 1945, she took part with her husband with the artistic council in the first Pancypriot Theatre (Prometheus) where she first acted in many works until she finished in 1946. In her later years (1947–56), she participated with the actor, director, husband Adamantios Lemos in his own Lemos Theatrical Company and in 1957–67, worked together in New York in the USA with the only Greek Theatre Organization in America.
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This may lead to reduced clearance of caffeine and a prolongation of the plasma's half-life that may lead to accumulation of caffeine in plasma when products containing caffeine are consumed while taking norfloxacin. The use of NSAIDs (Non Steroid Anti Inflammatory Drugs) while undergoing fluoroquinolone therapy is contra-indicated due to the risk of severe CNS adverse reactions, including but not limited to seizure disorders. Fluoroquinolones with an unsubstituted piperazinyl moiety at position 7 have the potential to interact with NSAIDs and/or their metabolites, resulting in antagonism of GABA neurotransmission. The use of norfloxacin concomitantly has also been associated with transient elevations in serum creatinine in patients receiving cyclosporine, on rare occasions, resulted in severe hypoglycemia with sulfonylurea.
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Ramsayville is a rural community on Ramsay Creek in Gloucester-Southgate Ward in Ottawa, Ontario, Canada. Prior to 2001, the community was located within the City of Gloucester. The immediate area around Ramsayville (North by the eastern prolongation of Hunt Club Road and Highway 417, west by Hawthorne Road, south by Leitrim Road and east by Anderson Road) has a population of about 90 (2011 Census)Population calculated by combining Census Blocks 3506148214, 3506148215, 3506148226 and 3506148233 The community was also a site used for High Frequency Direction Finding experiments by the Royal Canadian Navy. The Navy installation was located on Ramsayville Road (then known as Base Line Road) about five miles from Gloucester near the intersection of Leitrim Road.
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On emerging from the brainstem, the nerve is invested with a sheath of pia mater, and enclosed in a prolongation from the arachnoid. It passes between the superior cerebellar (below) and posterior cerebral arteries (above), and then pierces the dura mater anterior and lateral to the posterior clinoid process, passing between the free and attached borders of the tentorium cerebelli. It traverses the cavernous sinus, above the other orbital nerves receiving in its course one or two filaments from the cavernous plexus of the sympathetic nervous system, and a communicating branch from the ophthalmic division of the trigeminal nerve. As the oculomotor nerve enters the orbit via the superior orbital fissure it then divides into a superior and an inferior branch.
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The Royalists were now fighting with the courage of despair. Those who still fought against Charles did so with the full determination to ensure the triumph of their cause, and with the conviction that the only possible way was the annihilation of the enemy's armed forces. The majority, however, were so weary of the war that the Earl of Manchester's Presbyterian royalism, which had contributed so materially to the prolongation of the struggle, would probably have been accepted by four-fifths of all England as the basis of a peace. It was, in fact, in the face of almost universal opposition, that Fairfax and Cromwell and their friends at Westminster guided the cause of their weaker comrades to complete victory.
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MacCabe Corner has been described as the point at which the borders of the state of South Australia, Victoria and New South Wales meet. However the Geographical Names Board of New South Wales places MacCabe Corner at "The junction of the prolongation of the South Australia - New South Wales State border with the southern high bank of the Murray River being the New South Wales - Victoria State border."Geographical Names Register Extract : MacCabe Corner Geographical Names Board of New South Wales retrieved 18 February 2018 The boundary between Victoria and South Australia is the mid-line of the river. Thus the precise location of MacCabe Corner is at the south-west corner of New South Wales, approximately 100 metres from the place where the three state borders meet in the waters of the Murray River.
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These lessons were chosen from both the Old and New Testaments, and it would seem that there were three lessons as in some of the Oriental liturgies, one from the Old Testament, one from the Epistles in the New Testament, and one from the Gospels. The Third Council of Carthage decreed that only lessons from the canonical books of Scripture or from the acts of the martyrs on their feast days might be read in the churches. Between the Epistle and Gospel a psalm containing some idea in harmony with the feast of the day was recited, and corresponded to the gradual or tract in the Roman Mass. An alleluia was also sung, more or less solemnly, especially on Sundays and during the fifty days' prolongation of the Easter festival.
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In differential geometry and algebraic geometry it is often convenient to have a coordinate-independent description of differential operators between two vector bundles. Let E and F be two vector bundles over a differentiable manifold M. An R-linear mapping of sections is said to be a kth-order linear differential operator if it factors through the jet bundle Jk(E). In other words, there exists a linear mapping of vector bundles :i_P: J^k(E) \rightarrow F\, such that :P = i_P\circ j^k where is the prolongation that associates to any section of E its k-jet. This just means that for a given section s of E, the value of P(s) at a point x ∈ M is fully determined by the kth-order infinitesimal behavior of s in x.
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Saint-Basile Parish is defined in the Territorial Division Act as being bounded: :Southeasterly by Sainte-Anne [Parish]; northeasterly by the County line; southwesterly by the St. John River; and northwesterly by the lower line of grant numbered eighteen hundred and eight, near the mouth of the Madawaska River, granted to Simon Herbert in the year of our Lord one thousand eight hundred and twenty-five, and its northeasterly prolongation, including the islands in front, and excluding the Ordnance lands at the mouth of the Madawaska River, and all lands lying on the northwestern side of Green River from the mouth of Little Belone Brook at the Second Falls up stream to the Little Forks,Little Forks Branch Green River except the part thereof heretofore described establishing the Parish of Rivière-Verte.
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Himself an author and dissident, Virgil Tănase reflected back on the period: "Corrupted and sagged by a too lengthy and complacent convenience [...], Romanian writers viewed Paul Goma's effort with mistrust. A letter from Ion Negoiţescu and the support of Nicolae Breban, that is desperately little...""Paul Goma vu par... Virgil Tănase", in Bernard Camboulives, La Roumanie littéraire, Éditions le Manuscrit, Paris, 2005, p.330. While political scientist Vladimir Tismăneanu attributes to Goma and Negoiţescu's "quixotic stances, all the more heroic since [they] could not count on solidarity or support from colleagues", the status of a singular reaction against the local prolongation of Stalinism,Tismăneanu (2005), p.246 Matei Călinescu's account partly connects this issue with Negoiţescu having "miscalculated the reaction of his friends" by believing his gesture would be reciprocated.
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Even if under French rule, more than twenty segnories were granted along the bank of the river, all the way to Métis, and even inland (the segnories of Madawaska, Lac-Mitis and Lac-Matapédia), the settlement of Bas-Saint-Laurent remains sparse until 1790. With the exception of Kamouraska, which had a quicker colonization, in the prolongation of Côte-du-Sud and the royal path, Bas- Saint-Laurent remains isolated. When conquered, around 1760, the population east of Kamouraska is composed of a couple dozen families of pioneers and is concentrated in four seignories : Rivière-du-Loup, Isle-Verte, Trois-Pistoles and Rimouski. In 1790, Bas-Saint-Laurent, with the exception of Kamouraska, is home to barely 1250 inhabitants spread across hundreds of kilometers of shore, between Notre-Dame-du-Portage and Matane.
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Clomipramine may interact with a number of different medications, including the monoamine oxidase inhibitors which include isocarboxazid, moclobemide, phenelzine, selegiline and tranylcypromine, antiarrhythmic agents (due to the effects of TCAs like clomipramine on cardiac conduction. There is also a potential pharmacokinetic interaction with quinidine due to the fact that clomipramine is metabolised by CYP2D6 in vivo), diuretics (due to the potential for hypokalaemia (low blood potassium) to develop which increases the risk for QT interval prolongation and torsades de pointes), the selective serotonin reuptake inhibitors (SSRIs; due to both potential additive serotonergic effects leading to serotonin syndrome and the potential for a pharmacokinetic interaction with the SSRIs that inhibit CYP2D6 [e.g. fluoxetine and paroxetine]) and serotonergic agents such as triptans, other tricyclic antidepressants, tramadol, etc. (due to the potential for serotonin syndrome).
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In 1663 the Invisible College became The Royal Society of London for Improving Natural Knowledge, and the charter of incorporation granted by Charles II of England named Boyle a member of the council. In 1680 he was elected president of the society, but declined the honour from a scruple about oaths. He made a "wish list" of 24 possible inventions which included "the prolongation of life", the "art of flying", "perpetual light", "making armour light and extremely hard", "a ship to sail with all winds, and a ship not to be sunk", "practicable and certain way of finding longitudes", "potent drugs to alter or exalt imagination, waking, memory and other functions and appease pain, procure innocent sleep, harmless dreams, etc." They are extraordinary because all but a few of the 24 have come true.
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Simonds Parish is defined in the Territorial Division Act as being bounded: :North by the line between lots number ninety-three and ninety-four, near the mouth of Whitemarsh Brook and the westerly prolongation thereof; westerly by a line commencing on the northern boundary of Wakefield Parish, at a point where the eastern boundary of lot number thirty-two, granted to George Drake, in the third tier, strikes the same; thence running northerly along the eastern boundary of the said third tier to the eastern boundary of the grant to Arthur Blaney Walsh; thence northerly along the eastern boundary of the second tier of the Presquile block, until it strikes the northern boundary of the parish; south by Wakefield Parish; and east by the Saint John River, including all the islands in front.
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As x goes to positive infinity, the slope of the line from the origin to the point (x, x3) goes to positive infinity just as before. But unlike before, as x goes to negative infinity, the slope of the same line goes to positive infinity as well; the exact opposite of the parabola. So the behavior "at infinity" of V(y − x3) is different from the behavior "at infinity" of V(y − x2). The consideration of the projective completion of the two curves, which is their prolongation "at infinity" in the projective plane, allows us to quantify this difference: the point at infinity of the parabola is a regular point, whose tangent is the line at infinity, while the point at infinity of the cubic curve is a cusp.
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This resulted in the boundary running significantly north of the median line between the shores of Australia and Indonesia, thus benefiting Australia in terms of the division of the seabed ownership. The International Law view of settling overlapping claims has then moved towards the median-line concept, although Australia still holds the view that natural prolongation was still relevant to determine the sovereignty of the seabed. This resulted in the separate treatment of establishing the seabed boundary and that for the water column, or essentially, the separation of the continental shelf and exclusive economic zone boundaries under the 1997 treaty. The independence of East Timor on 20 May 2002 may result in changes in the Australia–Indonesia border near the Timor Gap which were established by the three treaties.
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However, prolongation in the workday requires the price of labor to fall. Marx elucidates that "the piece-wage therefore has a tendency, while raising the wages of individuals above the average, to lower this average itself," and "it is apparent that the piece-wage is the form of wage most appropriate to the capitalist mode of production". He gives examples of the weaving industry around the time of the Anti-Jacobin War where "piece- wages had fallen so low that in spite of the very great lengthening of the working day, the daily wage was then lower than it had been before". In this example, we are able to see how piece-wages do nothing but decrease the value of labor and better disguise the true way the workers are exploited.
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This resulted in the boundary running significantly north of the median line between the shores of Australia and Indonesia, thus benefiting Australia in terms of the division of the seabed ownership. The International Law view of settling overlapping claims has then moved towards the median-line concept, although Australia still holds the view that natural prolongation was still relevant to determine the sovereignty of the seabed. This resulted in the separate treatment of establishing the seabed boundary and that for the water column, or essentially, the separation of the continental shelf and exclusive economic zone boundaries under the 1997 treaty. The independence of East Timor on 20 May 2002 may result in changes in the Australia–Indonesia border near the Timor Gap which were established by the three treaties.
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The availability of synthetic toxin has allowed scientists to further explore the biological activity of the toxin, resulting in the observation that d-ACTX-Ar1a causes repetitive firing and prolongation of the action potential. These actions underlie the clinical symptoms seen following envenomation and further contribute to the understanding of the molecular basis for activity of this potent neurotoxin on voltage-gated sodium channels. Under voltage-clamp conditions in dorsal root ganglion (DRG) neurons is found that the effects of the synthetic toxin on sodium currents were not significantly different from those previously reported for the native toxin. Neither native nor synthetic d-ACTX-Ar1a had any effect on TTX-resistant sodium currents, but both exerted a potent selective modulation of TTX- sensitive sodium currents consistent with actions on neurotoxin receptor site-3.
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He was able to provide an intricate description of nerve cells in various regions of the cerebro-spinal axis, clearly distinguishing the axon from the dendrites. He drew up a new classification of cells on the basis of the structure of their nervous prolongation, and he criticized Gerlach's theory of the "protoplasmic network". Golgi claimed to observe in the gray matter an extremely dense and intricate network, composed of a web of intertwined branches of axons coming from different cell layers ("diffuse nervous network"). This structure, which emerges from the axons and is therefore essentially different from that hypothesized by Gerlach, appeared in his view to be the main organ of the nervous system, the organ that connected different cerebral areas both anatomically and functionally by means of the transmission of an electric nervous impulse.
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Side effects are generally similar to other antipsychotics. The drug has a relatively well tolerated side effect profile, with low propensity for QTc interval changes, weight gain and lipid-related adverse effects. In a 2013 meta-analysis of the efficacy and tolerability of 15 antipsychotic drugs it was found to produce the second least (after haloperidol) weight gain, the least QT interval prolongation, the fourth most extrapyramidal side effects (after haloperidol, zotepine and chlorpromazine) and the sixth least sedation (after paliperidone, sertindole, amisulpride, iloperidone and aripiprazole). As with other atypical neuroleptics, lurasidone should be used with caution in the elderly because it puts them at an increased risk for a stroke or transient ischemic attack; however, these risks are not likely to be greater than those associated with antipsychotics of other classes.
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Since the Sienese could not take Porto Ercole by force, the Commune of Siena insisted with great insistence on Pope Clement VII that he would return the lands occupied by force. Not obtaining positive responses and given the prolongation of the negotiations, the Republic decided to attack the port of call in 1530, managing to take back the port thanks to the commander Cincio Corso. Fearing an imminent war against the Emperor or against the Pope, the Commune had the towns and the castles of the Maremma visited by the architect Baldassarre Peruzzi and Antonmaria Lari who were in charge of strengthening the walls of Porto Ercole, Grosseto and Talamone in 1532 and in 1541. The fleet of Khayr al-Din Barbarossa, arrived in Italy to help the king of France, sacked and captured Montiano, Talamone and Porto Ercole.
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Dundas Parish is defined in the Territorial Division Act as being bounded: :South by the County line; west by the McLaughlin Road;Route 490 north by a line beginning at the seashore, at the northeastern angle of lot no. 1, granted to Joseph Richard; thence south seventy-two degrees and thirty minutes west seven hundred and sixty-five chains, or until it meets the westerly line of lot number 86, granted to Maximin A. Girouard; thence along the western line of said lot in a southerly direction, to meet the southern line of lot number 84, granted to Beloni Robicheau; thence westerly along the said southern line of the last-mentioned grant and its westerly prolongation to the eastern side of the McLaughlin Road; and east by the Gulf of Saint Lawrence, including all the islands in front.
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These both lie in the direct line of a valley that stretches with scarcely a break in between the Uri Alps and the Emmental Alps. At the eastern end of the Gersauer Becken, where the containing walls of the lake-valley are directed from east to west, it is joined at an acute angle by the arm of Uri, or the Urnersee, lying in the northern prolongation of the deep cleft that gives a passage to the Reuss, between the Uri Alps and the Glarus Alps.John Ball, The Alpine guide, Central Alps, p. 153, 1866, London View of the Lake of Uri from Brunnen southwards The Urnersee occupies the northernmost and deep portion of the great cleft of the Reuss Valley, which has cut through the Alpine ranges from the St Gotthard Pass to the neighbourhood of Schwyz.
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Nosferatu is a genus of cichlid fishes endemic to the Rio Panuco Basin and the tributaries of the adjacent Tamiahua Lagoon (to the South) and San Andrés Lagoon (to the North) in the states of Veracruz, Hidalgo, San Luis Potosí, Tamaulipas and Querétaro, Mexico. The genus is characterized by a prolongation in the size of the symphysial pair of teeth relative to that of the other teeth in the outer row of the upper jaw (nosferatuform teeth); breeding pigmentation that consists of darkening of ventral area extending over nostrils, opercular series, and pectoral fins; depressed dorsal fin rarely expands beyond anterior third of caudal fin; and an elongated, elastic, smooth caecum adhered to a saccular stomach. All species in Nosferatu had previously belonged to its sister genus Herichthys.Kullander, S.O. (2003): Check List of the Freshwater Fishes of South and Central America.
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Like the mastoid cells, it is filled with air and lined by a prolongation of the mucous membrane of the tympanic cavity, with which it communicates. The tympanic antrum is bounded above by a thin plate of bone, the tegmen tympani, which separates it from the middle fossa of the base of the skull, below by the mastoid process, laterally by the squama just below the temporal line, and medially by the lateral semicircular canal of the internal ear, which projects into its cavity. It opens in front into that portion of the tympanic cavity which is known as the attic or epitympanic recess. The tympanic antrum is a cavity of some considerable size at the time of birth; the mastoid air cells may be regarded as diverticula from the antrum and begin to appear at or before birth.
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They could withstand wind, cold, heat, or dampness, but there was not > a fat one among them. I admit that I have not yet met any who had not eaten > starches in several decades, but if some people cut off from starches for > only a couple of weeks die while these others look as well as they do after > years, why should we doubt that the (deliberate) fasting could be prolonged > still further? If those cut off from starches grow progressively weaker to > death, one would normally fear that such a diet simply cannot be prolonged, > but inquiry of those pursuing this practice reveals that at first all of > them notice a lessening of strength, but that later they gradually get > stronger month by month and year by year. Thus, there is no impediment to > the possibility of prolongation.
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However, lack of consistency and motivation was described as Safin's ultimate weakness, starting after his victory at the 2005 Australian Open. Safin generally dominated during the fast indoor hard/carpet season, which is usually during the last few weeks on tour; Safin considered grass to be his least favourite playing surface, despite the similarities between indoor courts and grass courts even though other opponents with similar playing styles generally dominate on it. He is known as one of the most talented players ever during his time on the tour, however his career was hampered by persistent injuries and lack of determination that prevented the prolongation of his dominance, and is therefore agreed by many pundits and fans as one of the biggest underachievers in tennis. Safin was also known for his emotional outbursts during matches, and smashed numerous rackets.
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311David F. Kelly, Medical Care at the End of Life (Georgetown University Press 2006 ), p. 3 The distinction was the basis of the declaration by the Congregation for the Doctrine of the Faith in 1980 that "when inevitable death is imminent in spite of the means used, it is permitted in conscience to take the decision to refuse forms of treatment that would only secure a precarious and burdensome prolongation of life, so long as the normal care due to the sick person in similar cases is not interrupted."Declaration on euthanasia Iura et bona, 5 May 1980 The Catechism of the Catholic Church also states: "Discontinuing medical procedures that are burdensome, dangerous, extraordinary, or disproportionate to the expected outcome can be legitimate".Catechism of the Catholic Church, 2278 Martini, in fact, refused medical treatment as his illness advanced.
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"Thousands protest in Niger against extension of Tandja's rule", AFP, December 27, 2008. On December 30, 20 non-governmental organizations and unions, including the Democratic Confederation of Workers of Niger (CDTN), formed the United Front for the Safeguarding of Democratic Gains (FUSAD) in opposition to the extension proposal, and they called on Tandja-- who had up to that point expressed no opinion on the matter in public--to speak out against the proposal."Niger: création d'un front contre la prolongation du mandat du président Tandja", AFP, December 30, 2008 . The relationship with the French nuclear company Areva, which had enjoyed a de facto four decade monopoly in the country, worsened under Tandja as he sought to curb the power of French influence by striking a deal with Sino-U in 2007 to develop a uranium mine, resulting in competition for Areva.
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Ramenki station was mentioned for the first time in 1965, when the Solntsevsky radius project was introduced, which at that time was supposed to be a continuation of the Arbat-Pokrovskaya line from the Kievskaya station. However, even the general scheme from 1938 for the development of the Moscow metro includes a promise for a Frunzensky radius station, designated approximately at the same location. The station was provided for by the project of prolongation in Solntsevo of the Arbat- Pokrovskaya line from the station "Park Pobedy", developed by the institute "Metrogiprotrans" in the early 1990s. In the variant of the line trace along Minskaya street and Michurinsky avenue it was offered at the intersection with Vinnytsia street, and according to the variant of the tracing through the Matveyevsky station it was to be shifted 200 meters to the south-west.
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Iberosuchus has ziphodont teeth that have a laterally compressed tooth crown that had a distally curved apex; anterior-posteriorly elongated dorsal osteoderms that have a keel running through the central median; rugose ornamentations with no pits and cupules; osteoderm lack anterolateral process; the skull is vermiculated; spoon-like premaxilla palatal shelf or mandibular symphysis; notch between premaxilla and maxilla or large 4th mandibular tooth; deep rostrum or mandible. It also had traits that it shared with other metasuchians, the dentary had lateral depressions and had a prolongation that extends dorsally behind the tooth row; the splenials are robust, had a big slot-like foramen intermandibularis oralis; had anteriorposteriorly elongated glanoid fossa on articular. Though only known by skull fragments and osteoderms, many artistic reconstructions use its close relatives such as Sebecus which has post cranial remains found as a reference.
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The victory of either side could only bring misery; and the prolongation of the war was a prospect equally unhappy. Falkland's ideals and hopes were now destroyed, and he had no definite political convictions such as inspired and strengthened Strafford and John Pym. In fact his sensitive nature shrank from contact with the practical politics of the day and prevented his rise to the place of a leader or a statesman. Clarendon has recorded his final relapse into despair: > Sitting amongst his friends, often, after a deep silence and frequent sighs > (he) would with a shrill and sad accent ingeminate the word "Peace, Peace," > and would passionately profess that the very agony of the war, and the view > of the calamities and desolation the kingdom did and must endure, took his > sleep from him and would shortly break his heart.
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The first two treaties to establish the seabed boundary between Australia and Indonesia utilised the "natural prolongation of the continental shelf" principle. Especially for the second treaty, Australia argued that the deep Timor Trough was the natural edge of its continental shelf. The resulting boundary was therefore located closer to Indonesia and had potentially denied considerable share of petroleum resources from the seabed. Despite the principle being agreed to via negotiations, its use had been a constant point of discontent on the part of the Indonesians, with its former Foreign Minister Mochtar Kusumaatmadja saying that the country had been "taken to the cleaners" by Australia.Robert J. King, “A Gap in the Relationship: the Timor Gap, 1972-2013”, March 2013, submission to the inquiry by the Australian Parliament Joint Standing Committee on Foreign Affairs, Defence and Trade into Australia's relationship with Timor-Leste.
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This liturgy can be used at present by the Coptic Orthodox Church of Alexandria, as well as by the Coptic Catholic Church, during the Lent time or in the month of Koiak, but its prolongation and particular melodies makes its use uncommon today. This text does not cover the whole Divine Liturgy, extending only from the pre-anaphorical rites (the prayer of the veil) to the distribution of the Communion, thus including the anaphora in the strict sense of the word. The Coptic Liturgy of Saint Basil is used for the remaining part of the service. In the Byzantine Rite, the Liturgy of Saint Mark, as transmitted by the Greek Orthodox Church of Alexandria, is used in a few places each year on the feast day of Saint Mark by the Russian Orthodox Church Outside Russia, which authorized it in 2007.
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Caraquet Parish is defined in the Territorial Division Act as being bounded: :North by Caraquet Bay and Caraquet Harbour; southeast by the Gulf of Saint Lawrence; east by a line running from the west side or entrance of Little Pokemouche LagoonBaie de Petit-Pokemouche north fifty-two degrees west until it strikes the south branch of Saint Simons Inlet,Baie Saint-Simon- Sud and thence from the centre of the said inlet and the north entrance of Grant Shippegan HarbourBaie de Shippegan. Originally the text read Grand Shippegan Harbour; the error occurred in the 1973 edition of the Revised Statutes of New Brunswick. to the Chaleur Bay; southwest and south by the northeast line of lot no. 1 (William Ferguson) and the prolongation thereof north thirty-six degrees west three hundred chains; thence in a direct line westerly to the northwest angle of lot no.
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The Eastern Gravettian had a long evolution, featuring several stages of development as documented especially by the settlements in Moldova. The Gravettian has left traces in the Ţara Oaşului and Ţara Maramureşului, the sites of microlite fashioned mainly out of obsidian indicating the connection with the Gravettian in the neighboring regions (Moldavia, South-Carpathian Ukraine, Eastern Slovakia, and Northeastern Hungary). The Late Gravettian covers Banat too, particularly the area of the Porţile de Fier of the Danube, where heads identical to the Laugerie-Basse type heads were discovered in grottoes and open air dwellings. Still in Banat, a culture with several stages of development was identified and subsequently named the Quartzite Upper Paleolithic by its discoverer, considered to be synchronous with the local Aurignacian, later the Gravettian, and regarded as a prolongation of the late stages of the Mousterian with quartz and quartzite tools (Eastern Charentian).
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The art historian, critic Manos Stefanidis wrote about Yannis Stavrou’s work in 2006 (excerpt from the essay under the title "Glass Eyes, Resurrected Gazes - On Yannis Stavrou's Paintings" by Manos Stefanidis): > “I see his paintings as a challenge for an inner voyage, an opportunity for > a resurrection of the gaze - a prolongation of real life. His compositions > are structured around two opposite poles: tenderness and a sturdy rhythm; a > sense for detail and understanding of the whole; a kind of sentimental > escape to mirthful images, as Kosmas Politis would put it, and a > preoccupation with form, represented in an unadorned and solid fashion. His > paintings keep alive the memory of those places he fell in love with in the > past or create novel seas for new journeys. Here plasticity is achieved via > abstractive processes, and elsewhere a tiny light - one catalytic > brushstroke - unveils a well-hidden secret.
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The town of Saint-Nazaire is located on the north bank of the Loire estuary (its territory includes the tip of Chémoulin which marks the end of the estuary), 50 km west of Nantes. It is near the marshes of Brière, an important regional natural park with many animal and plant species, the second largest wetland in France after the Camargue. According to INSEE, Saint-Nazaire is the commune-center of an urban unit (commonly: agglomeration) which counted 153,331 inhabitants in 2017,Unité urbaine de Saint-Nazaire (44601), INSEE gathering eleven communes located on the right bank of the Loire estuary and on its oceanic prolongation, from Donges to Le Croisic. This unit is the urban center of the urban area of Saint-Nazaire (23 towns), which has 196 596 inhabitants in 2010 and extending over Brière and almost all of the Guérande peninsula.
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A new drug application was filed with the United States Food and Drug Administration based on these trials and was rejected due to failure to show non-inferiority and due to safety concerns, especially drug-induced QT prolongation.. The FDA advisory committee said that the drug "should not be developed further" based on the results presented. A parallel application for marketing approval to the European Medicines Agency was withdrawn in 2009; in the announcement of the withdrawal, the EMA said that there was insufficient data from clinical studies to justify the dosage proposed by the company and that resistance to the drug had already been seen in the clinical trial data. Arpida collapsed after the rejection by the FDA and the EMA withdrawal. Arpida and the privately owned Swiss company Evolva began discussing an acquisition of Arpida by Evolva, which would allow Evolva to go public via a reverse merger in September 2009.
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The CPN team includes content and methods experts in each of the major causes of spontaneous or indicated very preterm birth, epidemiology, database design/maintenance, national networks, medical informatics, and statistical modelling. This project involves 24 tertiary perinatal units across Canada and focus on the major determinants of spontaneous and indicated very preterm birth (at 22+0–28+6 weeks): spontaneous preterm labour, shortened cervix, prolapsing membranes, preterm prelabour rupture of membranes, intrauterine growth restriction (abdominal circumference), gestational hypertension (with/without proteinuria), and antepartum haemorrhage.Admission criteria taken from: Canadian Perinatal Network Database Manual (May 2008). Data collection proceeds from the maternal and neonatal/infant/paediatric records, and include adverse perinatal and maternal outcomes, patient mix (including maternal demographics, past medical/obstetric history, characteristics of current pregnancy), neonatal care (for perinatal outcomes), and specific key obstetric practices (including maternal transport, cervical cerclage, amnioinfusion, fetal and maternal surveillance, pharmacological and non- pharmacological therapy, and pregnancy prolongation).
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The riding is located within the city of Ottawa. It is bounded on the north and east by Highway 417, on the west by the Rideau River and on the south by a line beginning at the Rideau River and Hunt Club Road, then east to Limebank Road, south to Leitrim Road, east to the CP Rail line, north to Lester Road, then east along Lester and Davidson Road to Conroy Road, north to Hunt Club Road and east along Hunt Club and its prolongation to Highway 417. Neighbouring districts include Ottawa—Vanier to the north, Orléans to the east, Carleton to the south and Ottawa West—Nepean and Ottawa Centre to the west. Ottawa South comprises the neighbourhoods of Riverview, Eastway Gardens, Alta Vista, Riverside Park, Billings Bridge, Heron Park, Mooney's Bay, Hunt Club Woods, Hunt Club Estate, Hunt Club Chase, South Keys, Ellwood, Heron Gate, Sheffield Glen, Airport- Uplands, Elizabeth Park, Windsor Park Village, and Blossom Park in the city of Ottawa.
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Suessula was on the line of the Via Popillia, which was here intersected by a road which ran from Neapolis through Acerrae, and on to the Via Appia, which it reached just west of the Caudine pass. The line of hills which rises from the level plain of Campania immediately above Suessula, and forms a kind of prolongation of the ridge of Mount Tifata, was a station almost as convenient as that mountain itself, and in 216 BCE, it was occupied by M. Claudius Marcellus with the view of protecting Nola, and watching the operations of Hannibal against that city (Liv. xxiii. 14, 17). From this time the Romans seem to have kept up a permanent camp there for some years, which was known as the Castra Claudiana, from the name of Marcellus who had first established it, and which is continually alluded to during the operations of the subsequent campaigns (Liv. xxiil. 31, xxiv.
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In the Travaux, Cartan breaks down his work into 15 areas. Using modern terminology, they are: # Lie theory # Representations of Lie groups # Hypercomplex numbers, division algebras # Systems of PDEs, Cartan–Kähler theorem # Theory of equivalence # Integrable systems, theory of prolongation and systems in involution # Infinite- dimensional groups and pseudogroups # Differential geometry and moving frames # Generalised spaces with structure groups and connections, Cartan connection, holonomy, Weyl tensor # Geometry and topology of Lie groups # Riemannian geometry # Symmetric spaces # Topology of compact groups and their homogeneous spaces # Integral invariants and classical mechanics # Relativity, spinors Cartan's mathematical work can be described as the development of analysis on differentiable manifolds, which many now consider the central and most vital part of modern mathematics and which he was foremost in shaping and advancing. This field centers on Lie groups, partial differential systems, and differential geometry; these, chiefly through Cartan's contributions, are now closely interwoven and constitute a unified and powerful tool.
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In 1961, he was in Pakistan to help with malaria disease control and eradication efforts by establishing training centres there and also frequently visited Delhi to observe the National Malaria Eradication Program that he described as "...something of a gigantic program in operation now in India". Due to the relatively later introduction of spraying for mosquitoes on a national scale in Pakistan, he advocated for prolongation of nationwide spraying efforts in India due to the possibility of transmission across the border areas. He noted the relatively better-off quality and systematic nature of training efforts for malaria eradication organised by the Malaria Institute of India and tried to organise training for senior leadership of the disease control efforts in Bangladesh and Pakistan, but this did not occur due to political reasons He also worked on Rabies and studied endemic typhus in the Himalayan foothills. He fell seriously ill with typhus while studying it.
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This landmark discovery has had implications for clinical care, diagnosis, medical ethics and medical/legal decision-making (relating to the prolongation, or otherwise, of life after severe brain injury). In a follow up paper in 2010 in The New England Journal of Medicine, Owen and his team used a similar method to allow a man believed to be in a vegetative state for more than 5 years to answer 'yes' and 'no' questions with responses that were generated solely by changing his brain activity using fMRI.Boseleys, S "Think tennis for yes, home for no: how doctors helped man in vegetative state" The Guardian, 3 February 2010. This research attracted international attention from the world's media; it was reported in many hundreds of newspapers around the world (including twice on the front page of The New York Times and other quality journals) and has been widely discussed on television (e.g. BBC News, Channel 4 News, ITN News, Sky News, CNN), radio (e.g.
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Since the main objective of the Japanese was the Chinese forces concentrated at Pyongyang, they had four routes on which to deploy their troops to Pyongyang; one through via Chemulpo, another through Pusan, one from Wonsan on the eastern coast of Korea or by landing directly at the mouth of the Taedong River in the immediate vicinity of Pyongyang. Since the Japanese were hard pressed for time, as part of their strategy they needed to drive the Chinese troops from Korea before winter to avoid prolongation of military operations. As a result the route leading through Pusan was rejected immediately; although transporting the troops there would not have been a problem for the Japanese as the transports would remain safely beyond the reach of the Chinese Fleet. The Japanese troops would have to travel over 650 km by land to reach Pyongyang, however considering the awful condition of Korean roads it would have taken them too much time to reach Pyongyang.
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In view of the COVID-19 pandemic, on 16 March 2020 the European Commission issued a recommendation to all EU and Schengen member states to introduce a temporary restriction on the entry of third-country nationals (i.e. travellers who are not EU/EEA/Swiss/British citizens and family members with the right of free movement) to the Schengen Area for non-essential travel for an initial period of 30 days (with the possible prolongation of this period to be assessed based on further developments). However, third-country nationals who are holders of long-term visas or residence permits or are family members of EU/EEA/Swiss/British citizens are exempt from this restriction. Further, third-country nationals 'with an essential function or need' (such as healthcare workers, transport personnel, aid workers, military personnel, seasonal agricultural workers), passengers in transit, those travelling 'for imperative family reasons' and those 'in need of international protection or for other humanitarian reasons' are exempt from this restriction.
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According to the historian Stanley G. Payne, after the end of the civil war there was no person more hated. Franco's side considered him a "red traitor", while within the Republican camp, some of his former allies reproached him for the "useless" prolongation of the war and for having "served" the plans of the Soviet Union. However, a New York Times editorial at the time of his demise characterized Negrín as follows: Gabriel Jackson's biography depicts Negrín as "a fundamentally honest and decent human being who sacrificed his health, reputation, and academic career in a failed attempt to save his country from disaster," and as "an accomplished scientist and cosmopolitan intellectual who in normal circumstances would have never had to become a politician, let alone take his country’s reins during the most difficult years of its long history." Nevertheless, Juan Negrín was one of the most controversial characters of the Spanish Civil War.
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Japan's main strategy was to gain command of the sea as this was critical to the operations on land. An early victory over the Beiyang fleet would allow Japan to transport troops and material to the Korean Peninsula, however any prolongation of the war would increase the risk of intervention by the European powers with interests in East Asia. The army's Fifth Division would land at Chemulpo on the western coast of Korea, both to engage and push Chinese forces northwest up the peninsula and to draw the Beiyang Fleet into the Yellow Sea, where it would be engaged in decisive battle. Depending upon the outcome of this engagement, Japan would make one of three choices; If the Combined Fleet were to win decisively, the larger part of the Japanese army would undertake immediate landings on the coast between Shanhaiguan and Tianjin in order to defeat the Chinese army and bring the war to a swift conclusion.
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Hill tribe (, ) (Northern Thai: จาวดอย, คนดอย, ; 'mountain people/folk')English-Thai dictionary entry for "hill tribe" is a term used in Thailand for all of the various ethnic groups who mostly inhabit the high mountainous northern and western regions of Thailand, including both sides of the border areas between northern Thailand, Laos and Burma, the Phi Pan Nam Range, the Thanon Range, the latter a southern prolongation of the Shan Hills, as well as the Tenasserim Hills in Western Thailand. These areas exhibit mountainous terrain which is in some areas covered by thick forests, while in others it has been heavily affected by deforestation.Forest data: Thailand Deforestation Rates The hill dwelling peoples have traditionally been primarily subsistence farmers who use slash-and-burn agricultural techniques to farm their heavily forested communities. Popular perceptions that slash and burn practices are environmentally destructive, governmental concerns over borderland security, and population pressure has caused the government to forcibly relocate many hill tribe peoples.
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In the meantime, Bernazard remained acting Speaker, appointed a bipartisan pair of co-chairs to every committee and kept the House working under unusual circumstances until a political agreement could relieve him of the unwanted and unsought prolongation of his duties as acting presiding officer and administrator of the House. He has been recognized by leaders of all political persuasions as someone who rose to the occasion and led with a steady hand until a political solution could be found to an unprecedented historical deadlock. Bernazard was subsequently appointed by Governor Carlos Romero Barceló as a member of the Puerto Rico Industrial Commission, a nomination that breezed through the confirmation process in an opposition-controlled Senate, in recognition of the historic role he had played in maintaining democratic stability in a time of crisis. From 1993 to 2000 completed his legislative staff career as Staff Director of the Senate Government Affairs Committee under two chairmen, Sen.
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Shediac Parish is defined in the Territorial Division Act as being bounded: :East by Botsford Parish, northeasterly by Northumberland Strait and the County line; south by Dorchester and Sackville Parishes, and west by the prolongation of the west line of the grant to Columb Connor on Shediac Road.Route 134 ::Notwithstanding anything contained in paragraphs (a) and (f), the dividing line between the Parishes of Botsford and Shediac shall be as follows: Beginning on the line separating the farms of the late Fidele LeBlanc (now called the Jude Boudreau farm) and lands formerly owned by Stephen Burk, where the said line crosses the main post roadPresumably Route 950 at Cap-Pelé, and following said farm line and its prolongations north four degrees and thirty minutes east by the magnet of the year nineteen hundred and three to the shore of Northumberland Strait, and also from said place of beginning south along said farm line and its prolongations four degrees and thirty minutes west to the Cumberland grant line.
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It is surrounded by orography that date of different ages: to the south the Guiana Shield, of Precambrian origin; and to the north and northwest the Venezuelan Coastal Range and Venezuelan Andes, whose genesis occur in the course of a long period ranging from the Cretaceous to the Pliocene. These emerged areas discharge most of their current waters to this plain, therefore, filled and acquired its present form as a result of the deposition processes caused by the large sedimentary masses that these water currents carry. That is why its origin is in that long process of filling that is fulfilled in the Tertiary; this process of landfilling is still maintained today. This region suffered a marine transgression, where this primitive sea was a prolongation of the Atlantic Ocean that, like a wide channel, penetrated in Venezuelan territory; so it was until the Upper Tertiary, and to a great extent until the Quaternary when there was a marine regression.
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Isabela is a hybrid town of sorts, with the rarity of being a coastline city that has beaches but is also known for its mountains (with peaks of over above sea level), rivers (surface and submarine), lakes, caves (surface and submarine), cliffs, coastal flats and forests (Tropical and Mangroves). Geographically, the municipality of Isabela belongs to the Northern Coastal Plains. Running through the south, the Aymamón mountains, a prolongation of the Jaicoa Mountain Range that begins in the neighboring town of Aguadilla, boasts peaks of over above sea level. The most prominent hills that are part of these mountains are La Bandera (Galateo Alto ward) at 1,207 ft (368 m); La Silla (Arenales Alto ward) at 1,106 ft (337 m); El Sombrero (in Galateo Alto) at 1,083 feet (330 m); Indio (Planas ward) at 1,017 feet (310 m); and Monte Encantado (in Arenales Altos) at 919 feet (280 m) of elevation above sea level.
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In February 1935, the Italian Consul Alberto Rossi wrote from Aleppo: :The Assyrians immigration in the High Jazira (...) goes on and is supported by the Mandate Power as it facilitates a secret but even more visible tendency: that of the creation of a new autonomous State, in spite of the theoretical discussions on the unity of the mandate. Some ‘mazbata’ have circulated by means of the same authorities (who know how to use this kind of popular petition when it is convenient for them) among the minority populations (Armenians and Kurds). They are asking the Mandatary Power for separation from Syria in order to create their own administration with their center in Deir ez-Zor. The French interest in the ‘Bec de Canard’ has increased after the railway prolongation (built on the back of the Syrians) of Baghdad... In 1936-1937 there was some autonomist agitation in the province among Assyrians and Kurds, supported by some Arab Bedouins.
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Due to the COVID-19 pandemic, on 16 March 2020 the European Commission issued a recommendation to all EU and Schengen member states to introduce a temporary restriction on the entry of third-country nationals (i.e. travellers who are not EU/EEA/Swiss/British citizens and family members with the right of free movement) to the Schengen Area for non-essential travel for an initial period of 30 days (with the possible prolongation of this period to be assessed based on further developments). However, third-country nationals who are holders of long-term visas or residence permits or are family members of EU/EEA/Swiss/British citizens are exempt from this restriction. Further, third-country nationals 'with an essential function or need' (such as healthcare workers, transport personnel, aid workers, military personnel, seasonal agricultural workers), passengers in transit, those travelling 'for imperative family reasons' and those 'in need of international protection or for other humanitarian reasons' are exempt from this restriction.
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Other factors in the prolongation of the Great Depression include trade wars and the reduction in international trade caused by barriers such as Smoot–Hawley Tariff in the U.S. and the Imperial Preference policies of Great Britain, the failure of central banks to act responsibly,M. Friedman "the severity of each of the major contractions – 1920–21, 1929–33 and 1937–38 is directly attributable to acts of commission and omission by the Reserve authorities". government policies designed to prevent wages from falling, such as the Davis–Bacon Act of 1931, during the deflationary period resulting in production costs dropping slower than sales prices, thereby injuring business profits and increases in taxes to reduce budget deficits and to support new programs such as Social Security. The U.S. top marginal income tax rate went from 25% to 63% in 1932 and to 79% in 1936, while the bottom rate increased over tenfold, from .
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Nepenthes lowii was discovered in March 1851 by British colonial administrator and naturalist Hugh Low during his first ascent of Mount Kinabalu. Low wrote the following account of his discovery: > A little way further we came upon a most extraordinary Nepenthes, of, I > believe, a hitherto unknown form, the mouth being oval and large, the neck > exceedingly contracted so as to appear funnel-shaped, and at right angles to > the body of the pitcher, which was large, swollen out laterally, flattened > above and sustained in an horizontal position by the strong prolongation of > the midrib of the plant as in other species. It is a very strong growing > kind and absolutely covered with its interesting pitchers, each of which > contains little less than a pint of water and all of them were full to the > brim, so admirably were they sustained by the supporting petiole. The plants > were generally upwards of 40 ft long, but I could find no young ones nor any > flowers, not even traces of either.
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In 1914, it was redefined to consist of the western part of the city of Hamilton described by a line drawn from the brow of the mountain along Dundurn Street, west along Aberdeen Avenue, north along Paradise Road to Cootes Paradise, along the south and east margins of the marsh to Burlington Bay, east along the bay, south along Hughson Street, east along King Street, south along Ferguson Avenue, west along Aberdeen Avenue and the Mountain Brow. In 1924, it was redefined to consist of the part of the city of Hamilton lying west of Wellington Street, east of Paradise Road, and north of Cootes Paradise. In 1935, it was redefined to exclude the part lying south of Concession Street, Claremont Drive and West Fifth Street. In 1952, it was redefined to consist of the part of the city of Hamilton lying north of the brow of the mountain and west of a line drawn from north to south along Wellington Street and its prolongation south to the brow of the mountain.
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The epicranial aponeurosis (aponeurosis epicranialis, galea aponeurotica) is an aponeurosis (a tough layer of dense fibrous tissue) which covers the upper part of the cranium in humans and various other animals. In humans, it is attached in the interval between its union with the occipitofrontalis muscle, to the external occipital protuberance and highest nuchal lines of the occipital bone; in front, it forms a short and narrow prolongation between its union with the frontalis muscle or frontal part of the occipitofrontalis muscle. On either side the epicranial aponeurosis gives origin to the anterior and the superior auricular muscles; in this situation it loses its aponeurotic character, and is continued over the temporal fascia to the zygomatic arch as a layer of laminated areolar tissue. It is closely connected to the integument by the firm, dense, fibro-fatty layer which forms the superficial fascia of the scalp: it is attached to the pericranium by loose cellular tissue, which allows the aponeurosis, carrying with it the integument, to move through a considerable distance.
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The long basin of water was built and flanked by plane trees, and the sculptures of the giant Polyphemus surprising the lovers Acis and Galatea, by French classical sculptor Auguste Ottin, were added to the grotto's rockwork.Paris et ses fontaines, de la Renaissance à nos jours, texts assembled by Dominque Massounie, Pauline-Prevost-Marcilhacy and Daniel Rabreau, Délegation a l'action artistique de la Ville de Paris, and Yves-Marie Allain and Janine Christiany, L'art des jardins en Europe, Citadelles & Mazenod, Paris, 2006. Hidden behind the Medici Fountain is the Fontaine de Léda, (1807), a wall fountain built during the time of Napoleon Bonaparte at the corner of the Rue du Regard and Rue de Vaugirard, with a bas-relief sculpture depicting the legend of Leda and the Swan by Achille Valois. When the original site was destroyed during the prolongation of the Rue de Rennes in 1856 by Louis Napoleon, the fountain was preserved and moved in 1866 to the Luxembourg Gardens and attached to the back of the Medici Fountain.
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Presidential candidates Klaus Iohannis, Elena Udrea and Monica Macovei urged the prolongation of the voting process in these countries. Moreover, the Presidential Administration demanded in a release the immediate resignation of Foreign Minister Titus Corlățean and Minister Delegate for Romanians Abroad Bogdan Stanoevici for poor organization of election in diaspora. Likewise, independent candidate Gheorghe Funar submitted an application to the President of BEC, demanding the cancellation of the first round of voting and its resumption because he considers that the equality of citizens before the law was not ensured, and the right to vote of Romanians abroad was seriously violated. These problems determined Gunther Krichbaum, the chairman of the Commission for European Affairs in the Bundestag to declare that the issue at stake does not concern "possible difficulties in the organisation of elections, but a wilful hindrance of the free expression of the votes", based on the current leftist government's knowledge of the fact that "Romanians living abroad have the tendency to vote with the parties and candidates of the centre-right".
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Malia states that "The Black Book offers us the first attempt to determine, overall, the actual magnitude of what occurred, by systematically detailing Leninism's 'crimes, terror, and repression' from Russia in 1917 to Afghanistan in 1989". Malia also argues against what he terms "the fable of 'good Lenin/bad Stalin'", stating that there never was a "benign, initial phase of Communism before some mytical 'wrong turn' threw it off track", claiming that Lenin expected and wanted from the start a civil war "to crush all 'class enemies'; and this war, principally against the peasants, continued with only short pauses until 1953". Malia further states that the Red Terror "cannot be explained as the prolongation of prerevolutionary political cultures", but rather as "a deliberate policy of the new revolutionary order; and its scope and inhumanity far exceeded anything in the national past". Malia laments that "'Positivist' social scientists [...] have averred that moral questions are irrelevant to understanding the past" and criticizes this perspective by arguing that it "reduces politics and ideology everywhere to anthropology".
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Indonesia and Australia held substantially different positions on how the Timor Gap should be delimited. Both positions were supported by conflicting sources of International Law, complicating the treaty making process. Australia proposed that the boundaries should be determined according to the Convention on the Continental Shelf 1958, which grants sovereignty to a nation over the continental shelf beyond their shores. Australia contended that the Timor Trough marked the edge of its continental shelf, giving the nation sovereignty over a significant share of the Timor Gap pursuant to the Convention. This position was upheld in the North Sea Continental Shelf Cases of 1969, where the International Court of Justice determined a state’s continental shelf to be the “natural prolongation of its land territory”. Indonesia’s position was based on the UN Convention on the Law of the Sea (UNCLOS) 1982, which gives a state full and exclusive rights over the 200 nautical miles from its territorial sea baseline, even if its continental shelf is geographically much smaller (unless proved that the continental shelf extends beyond this 200 nautical miles).
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Basis dorsally 0.60- 0.68 mm in width, the lateral submarginal fields swollen and frequently delimited from the depressed, median field by ill-defined carinae; posterior margin sinuous, posterolateral angles swollen, sometimes mildly salient; porose areas large, deep subcircular or oval, the longer axis directed anteriorly, interval frequently depressed, at most about the width of one; basis ventrally with posterior margin rounded and with well-defined, blunt, retrograde auriculae. Palps long and slender, some long hairs ventrally; article I rounded and somewhat salient laterally, inner 'ring' with dorsal tongue-like prolongation and ventrally semicircular and plate-like, the posterior margin of the plate extending beyond the palp; articles 2 and 3 with no apparent suture, 0.75- 0.85 mm in length and about four times as long as wide, narrowly rounded distally. Hypostome lanceolate and bluntly pointed; dentition mainly 3/3, the innermost file of small, spaced teeth, basally 2/2. Scutum: As wide as or a little wider than long, widest a little posterior to mid length, 1.6 x 1.7 mm- 2.4 x 2.4 mm, flat medianly, convex external to the long, strong lateral carinae; anterolateral margins practically straight, posterolateral margins mildly concave; posterior anle broadly rounded.
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After the Act became law on 26 June 2018, the European Council decided on 29 June to renew its call on Member States and Union institutions to step up their work on preparedness at all levels and for all outcomes. The Withdrawal Act fixed the period ending 21 January 2019 for the government to decide on how to proceed if the negotiations have not reached agreement in principle on both the withdrawal arrangements and the framework for the future relationship between the UK and EU; while, alternatively, making future ratification of the withdrawal agreement as a treaty between the UK and EU depend upon the prior enactment of another act of Parliament for approving the final terms of withdrawal when the current Brexit negotiations are completed. In any event, the act does not alter the two-year period for negotiating allowed by Article 50 that ends at the latest on 29 March 2019 if the UK has not by then ratified a withdrawal agreement or agreed a prolongation of the negotiating period. The Withdrawal Act which became law in June 2018 allows for various outcomes including no negotiated settlement.
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The Memorandum by Her Majesty's Government on the Report of the Constitution Committee, or the Hattersley Memorandum for short (by Roy Hattersley, Minister of State, Foreign and Commonwealth Office of the United Kingdom), dated 26 June 1976, was the answer of the Labour British Government to proposed constitutional changes in Gibraltar ruling out the possibility of integration of Gibraltar with the United Kingdom. In September 1975, Roy Hattersley (a Minister in the Foreign and Commonwealth Office) had visited Gibraltar and made it clear that the integration with the United Kingdom was not an option for Gibraltar. However, during early 1976, a Gibraltarian inter-party Constitution Committee began to work on a proposal of constitutional changes that involved a closer integration of Gibraltar with the United Kingdom, including responsibility for its affairs being transferred to the Home Office.Sovereignty and the Stateless Nation: Gibraltar in the Modern Legal Context, Keith Azopardi, Bloomsbury Publishing, 2009, page 98 A delegation of the Constitution Committee visited London in June 1976, but were unable to convince the United Kingdom Government which, as response, issued a memorandum dated 26 June 1976 rejecting the proposals on the grounds of "avoid innovations which might result in prolongation of the frontier restrictions imposed by Spain".
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