1000 Sentences With "moiety" | Random Sentence Generator

Long Lasting Loveliness continues at Moiety Gallery (166 N 12th Street, Williamsburg, Brooklyn) through July 17.

Currently, at Brooklyn gallery Moiety, she is collaborating with sculptor Lia Lowenthal in the exhibition Long Lasting Loveliness.

The typical clan consisted of about 50 to 200 people. The division of the Iroquois went as follows: Cayuga Moiety (A) clans: Bear, Beaver, Heron, Turtle, Wolf Moiety (B) clans: Turtle, Bear, Deer Tuscarora Moiety (A) clans: Bear, Wolf Moiety (B) clans: Eel, Snipe, Beaver, Turtle, Deer Seneca Moiety (A) clans: Heron, Beaver, Bear, Wolf, Turtle Moiety (B) clans: Deer, Hawk, Eel, Snipe Onondaga Moiety (A) clans: Tortoise, Wolf, Snipe, Eagle, Beaver Moiety (B) clan: Bear, Hawk, Eel, Deer Oneida Moiety (A) clan: wolf Moiety (B) clans: Bear, Turtle Mohawk Moiety (A) clans: Wolf, Bear Moiety (B) clan: Turtle. Government was by the 50 sachems representing the various clans who were chosen by the clan mothers. Assisting the sachems were the "Pinetree Chiefs" who served as diplomats and the "War Chiefs" who led the war parties; neither the "Pinetree Chiefs" or the "War Chiefs" were allowed to vote at council meetings.

The Kulin clans were divided in two subdivisons : one group the Waa (crow) moiety (group defined according to spiritual or totemic association), the other group Bunjil (eagle hawk) moiety. Waa was the Wurundjeri william moiety. It was important that when women and men came of age that they marry from the opposite moiety. That is, both men and women from the Bunjil moiety had to marry a partner from the Waa moiety.

The quinolinic acid is converted to nicotinic acid mononucleotide (NaMN) by transfer of a phosphoribose moiety. An adenylate moiety is then transferred to form nicotinic acid adenine dinucleotide (NaAD). Finally, the nicotinic acid moiety in NaAD is amidated to a nicotinamide (Nam) moiety, forming nicotinamide adenine dinucleotide. In a further step, some NAD is converted into NADP by NAD kinase, which phosphorylates NAD.

Since darunavir has a bis-THF moiety, instead of a single THF moiety like on amprenavir, it can form more hydrogen bonds and increase binding energy.

Pterocarpan chemical structure. It consists of a 1-benzofuran moiety (dotted blue circle) fused to a 2H-chromene moiety (dotted green circle). The systematic name for it is 6H-[1]benzofuro[3,2-c]chromene. The new numbering of the resulting moiety is shown with red numbers.

The center of the upper moiety was in Yotala about south of Sucre and the lower moiety was centered in Quilaquila, southwest of Sucre.Alconini (2004), p. 396 Each moiety had 10 ayllus (territorial clans).Alconini, Sonia (2016), Southeast Inka Frontiers, Gainesville: University Press of Florida, p. 41.

The combination of the syn-configuration of the methoxyimino moiety and the aminothiazole moiety confers extra stability to β-lactamase enzymes produced by many bacteria. The N-methylpyrrolidine moiety increases penetration into Gram-negative bacteria. These factors increase the activity of cefepime against otherwise resistant organisms including Pseudomonas aeruginosa and Staphylococcus aureus.

Members of one moiety traditionally may only marry a person of the opposite moiety, however in the last century this system began to break down (as a result of violent suppression of Tlingit culture and traditions) and today so-called "double-eagle" and "double-raven" marriages are common, as well as marriages with non-Tlingit people. No word in Tlingit refers to moiety, since referring to a particular person by their clan membership (see below) is enough to determine their moiety affiliation. In colloquial English the term "side" is often used among the Tlingit since "moiety" is a specialized term unfamiliar to most. The moieties provide the primary dividing line across Tlingit society, but identification is rarely made with the moiety.

Moiety classification is important in conflict resolution and in the organisation of authority. For a man to succeed his mother's brother as tsunono, the 'opposite' moiety (always either Nakaripa or Naboen) will hatsunono (make tsunono). During reconciliation ceremonies, the 'opposite' moiety will make speeches setting conditions on the reconciling parties and will preside over sacrifices.

A general letrozole pharmacophore model. Interaction between letrozole and amino acids in the binding site on the aromatase enzyme. 1,2,4 triazole ring binds to heme moiety. The cyano benzyl moiety is significant because it acts as carbonyl group of endogenous androstenedione. The active binding site of the aromatase enzyme is a subunit with a heme moiety (Fe2+).

The Makarrwanhalmirr are a Dhuwala clan of the Yirritja moiety.

The term moiety has some overlap with the term "functional group". However, a moiety is an entire "half" of a molecule, which can be not only a single functional group, but also a larger unit consisting of multiple functional groups. For example, an "aryl moiety" may be any group containing an aromatic ring, regardless of how many functional groups the said aryl has.

AFP is a glycoprotein of 591 amino acids and a carbohydrate moiety.

Semenogelase (, prostate-specific antigen, alpha-seminoprotein, seminin, P-30 antigen, antigen (human clone HPSA-1 prostate-specific protein moiety reduced), gamma-seminoglycoprotein (human protein moiety reduced), gamma-SM, antigen PSA (human prostate-specific), human glandular kallikrein, antigen PSA (human clone 5P1 protein moiety reduced)) is an enzyme. This enzyme catalyses the following chemical reaction : Preferential cleavage: -Tyr- This peptidase from trypsin family is present in seminal plasma.

The ribose moiety appears in some pharmaceutical agents, including the antibiotics neomycin and paromomycin.

Each moiety is further subdivided into clans, and each clan is subdivided into houses.

Finally, cleavage of the urethane group restores the amine and alcohol functionalities of the molecule (e). The result of this sequence of events is a unidirectional 120° rotation of the triptycene moiety with respect to the helicene moiety. Additional forward or backward rotation of the triptycene rotor is inhibited by the helicene moiety, which serves a function similar to that of the pawl of a ratchet. The unidirectionality of the system is a result from both the asymmetric skew of the helicene moiety as well as the strain of the cyclic urethane which is formed in c.

Concerned over the public outcry over the Sanborn incident, President Grant on June 22, 1874, signed a bill into law that completely put an end to the moiety contract system prohibiting the Secretary of Treasury to appoint special agent moiety Treasury collectors.

A guanidine moiety also appears in larger organic molecules, including on the side chain of arginine.

Instead of the pyridine- imidazole group used on telithromycin, this molecule has a triazole- phenylamine moiety.

The Ritharrngu (Ritharrŋu, Ritharngu) and also known as the Diakui (and variant spellings), are an Aboriginal Australian people of Arnhem Land in the Northern Territory, of the Yolngu group of peoples. Their clans are Wagilak and Manggura (of the Dua moiety), and Ritharngu (of the Yirritja moiety).

There is a basic moiety connected to a carbon chain linked to an aromatic moiety by an amide bridge. The amide bridge can be inverted without affecting the potency of the agonist. A biaryl group shows more potency than a monoaryl group as the aromatic moiety and substitution at position 2 on the later aryl group will further increase the potency. Potency is higher for agonists with H+ donor/acceptor on the later aryl group on the biaryl group.

However, additional studies indicate that, D-mannose-1-phosphate is the more likely starting point. 2\. Synthesis of naphthoic acid moiety: NcsB, NcsB1, NcsB2 and NcsB3 are enzymes responsible for the synthesis of the naphthoic acid moiety. This is similar to other enediyne natural products, the genes involved in construction of the aromatic moiety are an iterative type I PKS rather than a type II PKS system. The methyl group on the phenol group is added by SAM. 3\.

They are primarily organized into two moiety-like groups, the Nakaripa and Naboen. Unlike moieties in a true dual organization system, Nakaripa and Naboen are not exogamous in practice, though a strong preference for exogamy is usually reported. Exogamy is important in the organization of political power. Male and female chiefs attempt to organize cross-moiety marriages, the main reason for this being that the legitimation of chiefly power requires the participation of the opposite moiety.

MOPS is a similar pH buffering compound which contains a propanesulfonic moiety instead of an ethanesulfonic one.

Lactobionic acid has been used as a targeting moiety for drug delivery to cells expressing asialoglycoprotein receptors.

Alpha-agatoxins are composed of polyamines which are attached to an aromatic moiety (see for example AG 489).

Parsons, E. C. (1924). "Tewa kin, clan, and moiety". American Anthropologist, 26(3), 333–339.White, I. (1981).

The sweet taste sometimes has a barely perceptible almond like bitter aroma caused by the latent cyanide moiety.

The unusual boron moiety makes sure the fluorescence takes place in the visible light part of the electromagnetic spectrum.

Due to its estrogen moiety, alestramustine is selectively concentrated in estrogen receptor-positive cells such as prostate and breast.

Little is known of the tribe, other than that they were composed of several clans with a moiety system.

Based on the synergism of the heme oxygenase system and CO delivery, a new molecular hybrid-CORM (HYCO) class emerged consisting of a conjoined HO-1 inducer and CORM species. One such HYCO includes a dimethyl fumarate moiety which activates NRF2 to thereby induce HO-1, whilst the CORM moiety also liberates CO.

Amfenac, also known as 2-amino-3-benzoylbenzeneacetic acid, is a nonsteroidal anti-inflammatory drug (NSAID) with acetic acid moiety.

Azaspirodecane is a chemical compound. It is the core structure of the azaspirodecanedione moiety found in some of the azapirones.

Gamst (1969), p. 62 Each wambar also chose two stewards with different titles, one from each moiety, who served different elements of the sacred meals.Gamst (1969), p.43 There are two orders of priesthood, the kamazana, the higher, of the Keber moiety, and the abayegariya, the lower, of the Yetanti moiety. Each Qemant locality has at least one of each; they must work together to conduct the traditional sacrifices and other religious ceremonies. When offering a sacrifice, the abayegaria holds the legs of the victim and the kamazana wields the knife.

When the baby is born, the sisters encounter for the first time something that does not belong to the Dhua moiety as children take the opposite moiety from their mother's, making the baby Yirritja. Similarly, the rainbow serpent swallowing the sisters is also seen as an act of incest as the serpent is also of Dua moiety. While it is unclear if Yulunggur, the serpent, is male or female because it is often referred to as both, the encounter between he/she and the sisters is often interpreted as a symbolism of sex.

Moiety conservation is the conservation of a subgroup in a chemical species, which is cyclically transferred from one molecule to another.

Isavuconazonium comprises an N-(3-acetoxypropyl)-N-methylamino-carboxymethyl group linked through an ester moiety to the triazole nitrogen in isavuconazole.

An enzyme provides a methyl group that the right-sided hydroxyl selectively attacks, forming the methyl- ester moiety that characterizes aplysioviolin.

Tiemonium iodide is an antimuscarinic. It is poorly absorbed from the gut. The active moiety is tiemonium, a quaternary ammonium cation.

This gene encodes a protein that transfers a sulfo moiety to and from estrone, which may control levels of estrogen receptors.

Agrocin 84, having gained access to the A. tumefaciens C58 cytoplasm, is maturated into a toxic moiety that inhibits agrobacterial growth.

All chemosensors are designed to contain a signalling moiety and a recognition moiety. These are integrated directly or connected with a short covalent spacer depending on the mechanism involved in the signalling event. The chemosensor can be based on self- assembly of the sensor and the analyte. An example of such a design are the (indicator) displacement assays IDA.

Next, the dehydrogenase PltE desaturates the prolyl moiety on PltL to create pyrrolyl-PltL. The halogenation domain PltA then dichlorinates the pyrrole moiety first at position 5 and then at position 4 in a FADH2 dependent manner. The dichloropyrroyl residue is then transferred to the type I PKS PltB and PltC, however, the mechanism of transfer is unknown.

Seq1 is used to uniquely identify different variations (e.g. salts and esters), plant parts and extraction methods, thereby defining active substances or a combination of active substances. WHODrug records sharing the same DrugRecNo and Seq1 contain the same variation/plant part/extract variation of the same active moiety. For single-ingredient records, Seq1=01 identifies a specific active moiety.

Ossamycin is a fermentation-derived natural product belonging to a family of 22- to 26-membered macrocyclic polyketides which is featured with a 6,6-spiroacetal (1,7-dioxaspiro[5,5]-undecanyl) moiety connected to one side of the macrocycle.Oksana Bilyk, Markiyan Samborskyy, Peter F. Leadlay.The biosynthetic pathway to ossamycin, a macrocyclic polyketide bearing a spiroacetal moiety. PLoS ONE. 2019.14(4).

The moiety was purchased by the Astry family, The other moiety of Aust was held by Roger de Acton and was eventually sold to the Astry family. Reportedly it came into the Astry family in 1652. It was passed through several generations and was sold several times. In 1801 it was owned by Sacheverell Sitwell of Derbyshire.

There are 4 well characterized enzyme subgroups in this superfamily, which differ in their specificity for the sugar moiety of the substrate.

Like many other carboxylic acids, ceroplastic acid can react with UV curable moiety alcohols to form reactive esters, such as 2-allyloxyethanol.

The C-terminal moiety of the YARSs varies in sequence, length and organization and is involved in the recognition of the tRNA anticodon.

The antibody (or other targeting moiety) binds to an antigen on the target cell and the toxin then enters and kills the cell.

Drugs containing the tryptamine moiety are typically substrates for the serotonin receptors, in keeping with their close structural resemblance to serotonin, a neurotransmitter.

This gene encodes a protein that belongs to the SULT1 subfamily, responsible for transferring a sulfo moiety from PAPS to phenol- containing compounds.

Benzyl acetate has an ester functional group (in red), an acetyl functional group (encircled with dark green) and a benzyloxy moiety (encircled with light orange). Other divisions can be made. In organic chemistry, a moiety () is a part of a molecule which is typically given a name as it can be found within other kinds of molecules as well. The term moiety should be reserved to describe the larger characteristic parts of molecules and not used to describe smaller functional groups, which are made up of atoms that participate in similar chemical reactions in most molecules that contain them.

In pharmacology, an active moiety is the part of a molecule or ion – excluding appended inactive portions – that is responsible for the physiological or pharmacological action of a drug substance. Inactive appended portions of the drug substance may include either the alcohol or acid moiety of an ester, a salt (including a salt with hydrogen or coordination bonds), or other noncovalent derivative (such as a complex, chelate, or clathrate). The parent drug may itself be an inactive prodrug and only after the active moiety is released from the parent in free form does it become active.

Teslin is made up of two moieties; Wolf and Crow. Under the moiety of Wolf there are two clans; Eagle (Dakhl'awedi') and Wolf (Yanyedi). The Crow moiety have three clans; Raven's Children (Kukhhittan or Crow), Frog (Ishkitan) and Split tail Beaver (Deshitan). Under their matrilineal kinship system, children are considered born into the mother's clan, and descent is traced through her line.

Phenylacetones are a group of organic compounds containing a phenyl moiety and an acetone moiety bonded together, the archetypal example being phenylacetone. Phenylacetones often play a role in the illicit synthesis of amphetamine and its analogues, 3,4-methylenedioxyphenyl-2-propanone (MDP2P) for example being used in the production of 3,4-methylenedioxyamphetamine (MDA), 3,4-methylenedioxymethamphetamine (MDMA), 3,4-methylenedioxy-N- ethylamphetamine (MDEA), and other homologues.

Copper(II) sulfate pentahydrate decomposes before melting. It loses two water molecules upon heating at , followed by two more at and the final water molecule at . Dehydration proceeds by decomposition of the tetraaquacopper(2+) moiety, two opposing aqua groups are lost to give a diaquacopper(2+) moiety. The second dehydration step occurs when the final two aqua groups are lost.

The Ritharnggu language (Ritharrŋu, Ritharngu, Ritarungo) is an Australian Aboriginal language of the Yolŋu language group, spoken in Australia's Northern Territory. Dialects align with the two kinship moieties of the Ritharrngu people, one of several Yolngu peoples: (a) Ritharnggu (Yirritja moiety), and (b) Wagilak language (Dua moiety). The Manggurra (the other Dua clan) now speak Ritharnggu, but apparently shifted from Nunggubuyu.

Nitrogen dioxide. Nitryl is the nitrogen dioxide (NO2) moiety when it occurs in a larger compound as a univalent fragment. Examples include nitryl fluoride (NO2F) and nitryl chloride (NO2Cl). Like nitrogen dioxide, the nitryl moiety contains a nitrogen atom with two bonds to the two oxygen atoms, and a third bond shared equally between the nitrogen and the two oxygen atoms.

Cynaropicrin shows a reduction in parasitemia in murine models and has potent antitrypanosomal activity. It lowers intracellular GSH and trypanothione levels and inhibits trypanosomal ornithine decarboxylase with its α,β-unsaturated methylene moiety which acts as Michael acceptor. This leads to apoptosis of parasites. The 2-hydroxymethyl-2-propenoyl moiety was found to play an important role in the toxicity.

However, more recent work has stabilized the triboracyclopropenyl moiety via coordination to donor ligands or transition metals, dramatically expanding the scope of its chemistry.

The Ngarinjin were composed of roughly 40 hordes. Each of these local divisions had its own distinctive each with a clan and moiety classification.

On the other hand, the free hydroxy group on the C6 atom of the glucose moiety can be modified without loss of compound potency.

Removal of the alpha-methyl moiety yields the 2-carbon analogue, commonly known as 2C-E, another psychedelic compound first synthesized by Dr. Alexander Shulgin.

Both sexes are circumcised and the Tana Orma strictly adhere to marrying outside their moiety, a universally practised custom by all Oromo speaking people.Kelly, 1992.

In some cases the N-H hydrogens were aligned toward aromatic residues, and in others the cationic moiety was stacked above the π system. A particularly strong trend was found for close contacts between Arg and Trp. The guanidinium moiety of Arg in particular has a high propensity to be stacked on top of aromatic residues while also hydrogen-bonding with nearby oxygen atoms.

According to Spencer (1973), the Rendille are organized into an age grade system of patrilineal lineage groups (keiya), which are subsumed under fifteen clans (group). Of those, only nine are considered authentic Rendille. These Northern Rendille or Rendille proper are consequently the only ones that are included in the traditional Rendille moiety (belesi). The remaining six clans that are excluded from the moiety consist of mixed individuals.

267 (Helmingham) (Internet Archive). All the estates of Sarra's inheritance were then divided between the heirs of Bartholomew de Creke's sisters. In this complicated partition, one moiety of all went to John de Thorp, great-grandson of Margaret de Creke, and the other moiety was subdivided between Rohesia and Cecily de Valoines, great-granddaughters of Isabel de Creke.Calendar of Close Rolls, Edward I, Vol.

The coulombic interaction in TTF-TCNQ stems from the large partial negative charge (δ = -0.59) on the cyano- moiety on TCNQ at room temperature. For reference, a completely charged molecule δ = ±1. This partial negative charge leads to a strong interaction with the thio- moiety of the TTF. The strong interaction leads to favorable alignment of these functional groups adjacent to each other in the solid state.

If unsaturated esters are copolymerized with ethylene, either the alcohol moiety may be in the polymer backbone (as it is the case in ethylene-vinyl acetate copolymer) or of the acid moiety (e. g. in ethylene-ethyl acrylate copolymer). Ethylene-vinyl acetate copolymers are prepared similarly to LD-PE by high pressure polymerization. The proportion of comonomer has a decisive influence on the behaviour of the polymer.

A schematic outline of stepwise synthesis of NCS Chromophore The biosynthesis of neocarzinostatin takes place through a convergence of the activities of a gene cluster, which includes two separate iterative type I polyketide synthase (PKS) and deoxy sugar biosynthetic pathways. The first type I PKS gene, NcsE, codes for the enediyne moiety. The second type I PKS gene, NcsB, codes for the naphthoic acid moiety. Additionally, a cluster of NcsC genes are responsible for coding enzymes for the synthesis of the deoxyamino sugar moiety of NCS chromophore. The biosynthesis can be divided into three preliminary steps with a final convergence of the three moieties: 1\.

The amine group present on the triptycene moiety is converted to an isocyanate group by condensation with phosgene (a). Thermal or spontaneous rotation around the central bond then brings the isocyanate group in proximity of the hydroxyl group located on the helicene moiety (b), thereby allowing these two groups to react with each other (c). This reaction irreversibly traps the system as a strained cyclic urethane that is higher in energy and thus energetically closer to the rotational energy barrier than the original state. Further rotation of the triptycene moiety therefore requires only a relatively small amount of thermal activation in order to overcome this barrier, thereby releasing the strain (d).

A structure–activity relationship (SAR) study revealed that replacement of the dihalophenyl moiety by 3-benzothienyl increases maximal efficacy from 84% to 124% (Ki=2.7 nM).

Glufosfamide is, basically, a glycosidic conjugate between β-D-glucose and the active alkylating moiety of the well-known antineoplasic drug ifosfamide, so- called "isophosphoramide mustard".

4-Phenylthiosemicarbazide (4-PTSC) is a thiosemicarbazide used as an agricultural chemical and pesticide. It also possesses antibacterial properties attributed to electron delocalization in the thiosemicarbazide moiety.

According to the website of the Australian Institute of Aboriginal and Torres Strait Islander Studies, the Makarrwanhalmirr are a clan of the Yirritja moiety of the Yolgnu.

Brassica species contain glucosinolates, which are sulfur-containing secondary compounds. Glucosinolates are composed of a β-thioglucose moiety, a sulfonated oxime and a side chain. The synthesis of glucosinolates starts with the oxidation of the parent amino acid to an aldoxime, followed by the addition of a thiol group (through conjugation with glutathione) to produce thiohydroximate. The transfer of a glucose and a sulfate moiety completes the formation of the glucosinolates.

General structure of arylcyclohexylamines An arylcyclohexylamine is composed of a cyclohexylamine unit with an aryl moiety attachment. The aryl group is positioned geminal to the amine. In the simplest cases, the aryl moiety is typically a phenyl ring, sometimes with additional substitution. The amine is usually not primary; secondary amines such as methylamino or ethylamino, or tertiary cycloalkylamines such as piperidino and pyrrolidino, are the most commonly encountered N-substituents.

To get around this, Hou et al. developed a bumped pro-drug via methylation of the O6 of the galactose moiety of galactosyl-NONOate. They engineered a corresponding hole-modified β-galactosidase mutant, A4-β-GalH363A with specificity for the bumped galactosyl-NONOate. The bumped pro-drug evaded cleavage by wild type β-galactosidase due to the methylated O6 of the galactose moiety and strict regioselectivity of glycosidases.

Perimycin is produced naturally as a mixture of three types: A, B and C, with type A being the major component. All types consist of a polyketide core with a perosamine sugar moiety. The variations occur at the end of the core opposite the perosamine moiety. Perimycin A has an aromatic group in this position, whereas the identities of the analogous groups in the other perimycin types are currently undetermined.

Because of his black colouring, Balayang was associated with Crow, and thus belonged to the moiety in opposition to Eaglehawk. Another story credits him with creating or finding Crow women (and thus marriage partners for the Eaglehawk moiety). One day Balayang was amusing himself by thumping the surface of the water, causing it to thicken into mud. Something stirred underneath the mud and, probing with a branch, he found two women.

The amide moiety of the pyrazolopyrimidinone group forms a bidentate hydrogen bond with the ɣ-amide group of Gln817. 3D structure of sildenafil is demonstrated in figure 4.

The other moiety of the manor was eventually acquired (from Thomas Botreaux) in 1444 by his descendant John Beauchamp, 1st Baron Beauchamp (d. 1475) "of Powick" in Worcestershire.

This functional group appears in a variety of medications, particularly cardiac (antiarrhythmic) drugs, as a sulfonamide moiety. Examples include sotalol, ibutilide, sematilide, dronedarone, dofetilide, E-4031, and bitopertin.

Drugs containing the phenethylamine moiety bear close structural resemblance to dopamine but substitution on the benzene ring gives rise to drugs with a much higher affinity for serotonin receptors.

These cultures overlapped to a greater or lesser extent, and evolved over time. The two moiety totems of the Woiwurrung people are Bunjil the Eaglehawk and Waang the Crow.

Squibb developed the first ACE inhibitor, captopril, but it had adverse effects such as a metallic taste (which, as it turned out, was due to the sulfhydryl group). Merck & Co. developed enalapril as a competing prodrug. Enalaprilat was developed partly to overcome these limitations of captopril. The sulfhydryl moiety was replaced by a carboxylate moiety, but additional modifications were required in its structure-based design to achieve a potency similar to captopril.

The origins for the division of Churton into two townships goes back to the 11th century. It has been suggested that in 1086 Aldford was originally part of the moiety of the manor held by Earl Edwin and Bigot. Churton by Farndon was a moiety belonging to the Bishop of Chester. The west–east dividing line of this ecclesiastical boundary is followed by the streets of Knowl Lane, Hob Lane, and Pump Lane.

The Haida nation was split between two moieties, the Raven and the Eagle. Marriages between two people from the same moiety were prohibited. Due to this any children that were born after the marriage would officially become part of the moiety that the mother had come from. Each group provided its members with entitlement to a vast range of economic resources such as fishing spots, hunting or collecting areas, and housing sites.

There is need for a drug with pharmacological effects similar to semaxanib and sunitinib, but it needs to be less toxic. MPEG3-9-semaxanib is semaxanib with an additional water-soluble, non-peptidic oligomer attached to it via a spacer moiety. MPEG3-9-semaxanib derivatives are 10 times more active against VEGFR-2 than sunitinib. Compounds with sunitinib heterocyclic moiety but different amide side chains inhibit VEGFR-1 and VEGFR-2 and regulate disorders.

Malonyl-CoA:ACP Transacylase uses a ping-pong kinetic mechanism with a bound malony ester as the acyl intermediate attached to a serine residue residing within a GHSLG pentapeptide. FabD first binds malonyl-CoA, the malonyl moiety is then transferred to the active siteSer 92, and CoA is released from the enzyme. ACP then binds and the malonyl moiety is transferred to the terminal sulfhydryl of the ACP prosthetic group. This reaction is readily reversible.

The Lipid A moiety is a very conserved component of the LPS. However Lipid A structure varies among bacterial species and Lipid A structure defines an overall host immune activation.

The isocyanamide functional group consists of a amino group attached to an isocyano moiety. for nomenclature as suffix of isonitrile or prefix of isocyano is used depending upon priority table.

Worl's Tlingit names are Yeidiklasókw and Kaaháni. She is of the Ch’áak’ (Eagle) moiety of the Shangukeidí (Thunderbird) Clan from the Kawdliyaayi Hít (House Lowered from the Sun) in Klukwan.

Prymnesins-B1 is formed of a large polyether polycyclic core with several conjugate double and triple bonds, chlorine and nitrogen heteroatoms and a single sugar moiety consisting of α-D-galactopyranose.

The attachment of the butyl-bromide moiety effectively prevents the movement of this drug across the blood–brain barrier, effectively minimising undesirable central nervous system side effects associated with scopolamine/hyoscine.

This category encompasses the simplest approach of coupling an electrophile with low intrinsic reactivity to a noncovalent binding moiety which frequently mimics the natural substrate. Key to this designation is that the reactivity of the electrophile is not altered by the enzyme and that the noncovalent binding moiety serves to increase the presence and lifetime of the electrophile in the active site (effective molarity). The weakly reactive group may react with functional groups outside of the active site or on other proteins but the selectivity is conferred by the noncovalent binding moiety. Kinetic signatures of this type of inhibitor can be found in saturation because of the covalent reaction (kinact) becomes the rate limiting step at high concentrations of inhibitor.

Woodlock died in 1318 with his son William inheriting the moiety; his wife Margaret possessed this part of the manor in 1347, and when she died it passed to John Woodlock and his wife Agnes. They owned the moiety in 1379 and passed it on to their daughter Joan, who was in possession of it by 1408. Joan had two husbands, William Oysell at the time of her ownership of the moiety and William Park later on. In 1408 the property was transferred to John Fromond, steward of Winchester College. When he died in 1420 all his property in Allington was left to the college, to help clothe the Winchester College Chapel Choir, with his wife retaining a life interest until her death in 1442.

Benzyl acetate has an ester functional group (in red), an acetyl moiety (circled with dark green) and a benzyloxy moiety (circled with light orange). Other divisions can be made. In organic chemistry, functional groups are specific substituents or moieties within molecules that may be responsible for the characteristic chemical reactions of those molecules. The same functional group will undergo the same or similar chemical reaction(s) regardless of the size of the molecule it is a part of.

In the Kulin nation in central Victoria he was regarded as one of two moiety ancestors, the other being Waa the crow. Bunjil has two wives and a son, Binbeal the rainbow. His brother is Palian the bat. He is assisted by six wirmums or shamans who represent the clans of the Eaglehawk moiety: Djart-djart the nankeen kestrel, Thara the quail hawk, Yukope the parakeet, Lar-guk the parrot, Walert the brushtail possum and Yurran the gliding possum.

For acetic acid, the hydrogen (δ+) on the alcohol moiety of the carboxylic acid hydrogen bonds with other the carbonyl moiety (δ-) of the carboxylic on the adjacent molecule. This hydrogen bond leads a string of acetic acid molecules hydrogen bonding to minimize free energy. These strings of acetic acid molecules then stack together to build solids. The halogen bonding between the bromine and 1,4-dioxane molecules partially guides the organization of the crystal lattice structure.

Peptide bond formation via dehydration reaction.When two amino acids form a dipeptide through a peptide bond it is a type of condensation reaction. In this kind of condensation, two amino acids approach each other, with the non-side chain (C1) carboxylic acid moiety of one coming near the non-side chain (N2) amino moiety of the other. One loses a hydrogen and oxygen from its carboxyl group (COOH) and the other loses a hydrogen from its amino group (NH2).

The active site is lined with a number of charged residues and a number of residues with hydrogen-bonding potentials, which together comprise a potential network for substrate binding and catalysis. The active site is also lined with aromatic residues which provide favourable environments for the base moiety of dTDP and potentially for the sugar moiety of the substrate. As of late 2007, 14 structures have been solved for this class of enzymes, with PDB accession codes , , , , , , , , , , , , , and .

They are named ansamycins (from the Latin ansa, handle) because of their unique structure, which consists of an aromatic moiety bridged by an aliphatic chain. The main difference between various derivatives of ansamycins is the aromatic moiety, which can be a naphthalene ring or a naphthoquinone ring as in rifamycin and the naphthomycins. Another variation consists of benzene or a benzoquinone ring system as in geldanamycin or ansamitocin. Ansamycins were first discovered in 1959 by Sensi et al.

Some substances are stable in solution or some other "wild" form but cannot be isolated or captured without actually catalyzing their own polymerization or decomposition ("dissolving in their own tears"). For example, a molecule containing a carboxylic acid moiety and an acid labile moiety might be stable when initially prepared as the salt (e.g., barium prephenate) but unstable as the free acid (prephenic acid). These have been named "chemical squonks" as a nod to the creature.

This moiety of the manor passed to the Lilfords. The other moiety was granted to Roger de Douay, and then to Gilbert de Notton who gave Cockersand Abbey one ploughland. This portion, Holmeswood, was eventually acquired by the Heskeths of Rufford and sold to the Lilfords around 1886, uniting both portions. In the 19th century a labourer discovered a small leaden box without a lid containing about a hundred silver coins whilst digging in a copse.

Therefore, they are also sometimes referred to as thiol proteases. The thioester bond is subsequently hydrolyzed to generate a carboxylic acid moiety on the remaining substrate fragment, while regenerating the free enzyme.

Heptobarbital (Rutonal), also known as phenylmethylbarbituric acid is a barbiturate derivative. It has often been confused with methylphenobarbital because both drugs contain a methylphenyl moiety and are overall very similar in structure.

The base structure of camalexin consists of an indole ring derived from tryptophan. The ethanamine moiety attached to the 3 position of the indole ring is subsequently rearranged into a thiazole ring.

Of the three catalysts, Zhan Catalyst-1B and -1C both contain a dimethylsulfonamide moiety attached to the aryl ring, while Zhan Catalyst-II is connected to a resin via a sulfonamide linker.

Arriba-abajo distinctions are common throughout Latin American small towns and are not moiety divisions in the strict ethnological sense; however, they may be utilized in this manner by some indigenous groups.

Gantacurium represents the third generation of tetrahydroisoquinolinium (THIQ) neuromuscular blocking drugs in a long lineage of compounds invented by medicinal chemists and scientists at Burroughs Wellcome Co., Research Triangle Park, North Carolina. Unlike all other clinically used tetrahydroisoquinolinium agents except cisatracurium, gantacurium is a stereo- and regioselective single isomer. And unlike any other traditional symmetrical predecessors in the family of bisbenzyltetrahydroisoquinolinium neuromuscular-blocking drugs, gantacurium is an asymmetric bis-onium ester of α-chlorofumaric acid: this particular feature arises solely from the (1R)-trans benzyltetrahydroisoquinolinium moiety at one onium head and a (1S)-trans phenyltetrahydroisoquinolinium moiety at the other onium head. The chlorine atom lies on the same side of the double bond as the benzyl-THIQ moiety (or the opposite side to the phenyl-THIQ moiety). Although the carboxylic acid groups are in opposite relationship across the double bond, as in fumaric acid [(E)-but-2-ene dioic acid], the chlorine atom is given the higher priority, so it's named as a (Z)-configuration at this stereobond.

Structurally, elemcin is similar to myristicin, differing only by myristicin's methyl group that joins the two oxygen atoms that make up its dioxymethy moiety, with both constituents being found in nutmeg and mace.

Cefonicid is synthesized conveniently by nucleophilic displacement of the 3-acetoxy moiety of 1 with the appropriately substituted tetrazole thiole 2. The mandelic acid amide C-7 side chain is reminiscent of cefamandole.

Inosine triphosphate (ITP) is an intermediate in the purine metabolism pathway, seen in the synthesis of ATP and GTP. It comprises an inosine nucleotide containing three phosphate groups esterified to the sugar moiety.

Moiety is a Middle English word for one of two equal parts under the feudal system.Blackstone, William. (2003). Blackstone's Commentaries on the Laws of England, p. 435. Thus on the death of a feudal baron or lord of the manor without a male heir (the eldest of whom would inherit all his estates by the custom of male primogeniture) but with daughters as heiresses, a moiety of his fiefdom would generally pass to each daughter, to be held by her husband.

Not only landholdings but also the holding of offices of state could devolve by moiety. In the Royal Court of the United Kingdom, one moiety of the ancient office of Lord Great Chamberlain is a hereditary office of the Cholmondeley family. Notes and Queries (1883 Jan-Jun), p. 42. This hereditary office came into the Cholmondeley family through the marriage of the first Marquess of Cholmondeley to Lady Georgiana Charlotte Bertie, daughter of Peregrine Bertie, 3rd Duke of Ancaster and Kesteven.

Phlorizin consists of glucose moiety and two aromatic rings (aglycone moiety) joined by an alkyl spacer. Initially, phlorizin was isolated for treatment of fever and infectious diseases, particularly malaria. According to Michael Nauck and his partners, studies were made in the 1950s on phlorizin that showed that it could block sugar transport in the kidney, small intestine, and a few other tissues. In the early 1990s, sodium/glucose cotransporter 2 was fully characterized, so the mechanism of phlorizin became of real interest.

One moiety was in the possession of the Stanley family from 1693 onwards, the other moiety passed to Lady Mary Talbot, and thence after 1772 into Drummond family. The Cadland estate, which stretched down the coast of Southampton Water for nearly eight miles, was the residence of the Drummond family, who owned most of the land in the parish. Cadland house was built in 1773, but was greatly enlarged in 1836; it burnt down in 1916 but was rebuilt in 1935.Fawley - southernlife.org.

400px The final one-pot operation begins with a Curtius Rearrangement of acyl azide (7) to produce an isocyanate functional group at room temperature. The isocyanate derivative then reacts with acetic acid to yield the desired acetylamino moiety found in (1). This domino Curtius rearrangement and amide formation occurs in the absence of heat, which is extremely beneficial for reducing any possible hazard. The nitro moiety of (7) is reduced to the desired amine observed in (1) with Zn/HCl.

This unique selectivity can be induced fit mechanisms and structural features that are unique to UCK2 among the NMP kinase family. Studies have shown that the binding of the cytidine/uridine sugar moiety results in the conformational change to reduce the distance between the His-117 and Arg-176 residues. Without the 2’-hydroxyl group on the sugar moiety, hydrogen bonding with Asp-84 and Arg-166 will be greatly reduced, resulting in diminished conformational change and weakened substrate binding.

The earliest known record of a manor of Upton is from the reign of Edward the Confessor, when it was held by a Saxon freeman called Brictric. Shortly after the Domesday Book was completed in 1086 Upton became the property of Wynebald de Ballon who in 1092 granted a moiety of the manor to the Cluniac Bermondsey Abbey. The abbey retained this moiety until the Dissolution of the Monasteries in the 16th century, when it surrendered all its lands to the Crown.

One limitation of classic yeast two-hybrid screens is that they are limited to soluble proteins. It is therefore impossible to use them to study the protein–protein interactions between insoluble integral membrane proteins. The split-ubiquitin system provides a method for overcoming this limitation. In the split- ubiquitin system, two integral membrane proteins to be studied are fused to two different ubiquitin moieties: a C-terminal ubiquitin moiety ("Cub", residues 35–76) and an N-terminal ubiquitin moiety ("Nub", residues 1–34).

The chlorothiophene moiety binds to Tyr-228 at the bottom of the S1 pocket, making it a key factor regarding binding to FXa. Rivaroxaban has both high affinity and good bioavailability. left Apixaban200x200px During the SAR development of apixaban there were three groups that needed to be tested to attain maximum potency and bioavailability. The first group to be tested was the non-active site as it needs to be stabilized before SAR testing on the p-methoxyphenyl group (S1 binding moiety).

Mamecestre (Chet. Soc), ii, 289, 290. In 1331 a settlement of a moiety of the manor was made by Ellis de Lever in favour of his son and his issue by Agnes his wife.

The presence of the dihydroxyphenylalanine-moiety arises from action of a tyrosine hydroxylase- type of enzyme; in vitro, it has been shown that the proteins can be cross- linked (polymerized) using a mushroom tyrosinase.

The Gunwinggu people practiced Dzamalag when they wished to exchange items with another moiety, or party. An example of dzamalag held in the 1940s shows the main exchange being serrated spears and European cloth.

The structure of iproniazid is chemically, in both structure and reactivity, similar to isoniazid. Iproniazid is a substituted hydrazine of which the isopropyl hydrazine moiety is essential for the inhibition of monoamine oxidase activity.

The stability of this configuration results in increased activity of ceftriaxone against otherwise resistant Gram-negative bacteria. In place of the easily hydrolyzed acetyl group of cefotaxime, ceftriaxone has a metabolically stable thiotriazinedione moiety.

Bayer Healthcare AG synthesized Repinotan in three main reaction sequences. A form with a metabolically stable 14carbon- label was necessary for pharmacokinetic studies. The hydrochloride was hydroxylated in the 6-position of the chromane moiety.

Wenhaston church was held as a moiety in 1281 (when confirmed by Archbishop Peckham),Page, Victoria County History II (1907), p. 92; citing Cartulary, fol. 25. not including the chapel of Mells in the west.

AL-LAD does not cause a color change with the Marquis, Mecke or Mandelin reagents, but does cause the Ehrlich's reagent to turn purple because of the presence of the indole moiety in its structure.

It is an astringent compound. It is also found in wine, red or white, aged in oak barrels. It is a castalagin glycoside, by binding of the pentose lyxose. It contains a nonahydroxytriphenic acid moiety.

Pancuronium and some other neuromuscular blocking agents block M2-receptors and therefore affect the vagus nerve, leading to hypotension and tachycardia. This muscarinic blocking effect is related to the acetylcholine moiety on the A ring on pancuronium. Making the N atom on the A ring tertiary, the ring loses its acetylcholine moiety, and the resulting compound, vecuronium, has nearly 100 times less affinity to muscarin receptors while maintaining its nicotinic affinity and a similar duration of action. Vecuronium is, therefore, free from cardiovascular effects.

Deals with a dispute between James Fleming, Baron > of Slane, on the one side and John Bellewe, Patrick his son, Amy wife of > John Bellewe, Walter Delune and Amy his wife, on the other side, over the > lands late belonging to Christopher Fleming, knight, in Devon. The award > provides that (1) Patrick Bellewe shall have a moiety of rents worth > £10.2s., from lands in South Molton parish, and a moiety of lands called > Asshrogus (i.e. Ash Barton Estate), in Braunton, and of Puttesburgh in > Georgeham.

Capsaicinoids and capsinoids are characterized by an oxygenated aromatic moiety bound via an amide(capsaicinoids) or ester (capsinoids) linker to a lipophilic acyl group. The vanillyl and carbonyl linker contain polar groups capable of forming hydrogen bonds essential for activity, whereas the lipophilic moiety interacts with a corresponding cleft of the vanilloid binding site on TRPV1. Replacement of the medium-sized branched fatty acid of capsaicin with longer fatty acids is damaging for activity, but the presence of unsaturations restores and potentiates activity e.g. oleoylvanillamine (olvanil)(fig.

Isleta (and the Sandia) have matrilineal kinship systems, with descent and inheritance traced through the mother's family; the children are considered born to her people and receive their status from her family or corn group, akin to a clan. They have an endogamous system of marriage. These kinship/cultural divisions are connected with the sacred directions and colors, as well as tribal lineages, clans, phratries, and moieties. In the moiety system, one moiety is connected with winter practices, and the other with the summer practices and traditions.

The Umpila call themselves Umpila pama malngkanichi, "people of the sand beach", a term which refers to their belonging to the ethnocultural group of Kawadji of north-eastern Queensland coastal dwellers. Their society had two exogamous patrimoieties, kaapay(karrpiya/ karpeya) and kuyan (koiyan), two terms which are also used to classify flora and fauna. The two patrimoieties marry their opposite moiety, resulting in the acquisition of the resulting children to the father's moiety. Strict rules also govern social interaction between certain grades of affine relationship.

Moiety societies are found particularly among the indigenous peoples of North America and Australia (see Australian Aboriginal kinship for details of Aboriginal moieties).Tooker, E. (1971). "Clans and moieties in North America". Current Anthropology, 357–376.

A large group of organocatalysts incorporate the urea or the thiourea moiety. These catalytically effective (thio)urea derivatives termed (thio)urea organocatalysts provide explicit double hydrogen-bonding interactions to coordinate and activate H-bond accepting substrates.

The R groups do not have to be identical. In the dyes as used they are short aliphatic chains one or both of which ends in a highly reactive moiety such as N-hydroxysuccinimide or maleimide.

The biogenesis of the outer membrane requires that the individual components are transported from the site of synthesis to their final destination outside the inner membrane by crossing both hydrophilic and hydrophobic compartments. The machinery and the energy source that drive this process are not yet fully understood. The lipid A-core moiety and the O-antigen repeat units are synthesized at the cytoplasmic face of the inner membrane and are separately exported via two independent transport systems, namely, the O-antigen transporter Wzx (RfbX) and the ATP binding cassette (ABC) transporter MsbA that flips the lipid A-core moiety from the inner leaflet to the outer leaflet of the inner membrane. O-antigen repeat units are then polymerised in the periplasm by the Wzy polymerase and ligated to the lipid A-core moiety by the WaaL ligase.

397 This moiety contract system, although legal, led to extortion abuse in the loosely run Treasury Department under Sec. Richardson.Spencer (1913), pp. 452–453.McFeely-Woodward (1974) pp. 147–148. John D. Sanborn was contracted by Sec.

Both the lipid moiety of the tail and the sugar residues in the glycan core has considerable variation,Nosjean O. et al. (1997) Mammalian GPI proteins: Sorting, membrane residence and functions. Biochim Biophys Acta. 1331, 153-86.

Analysis of human and rat urine for the metabolites of bk-amphetamines suggested that ethylone was degraded in the following metabolic steps: # N-deethylation to the primary amine. # Reduction of the keto moiety to the respective alcohol.

Interacts with the cofactor or prosthetic group, FAD of flavoproteins and contains a flavin moiety in the form of FAD or FMN (flavin mononucleotide). The domain non-covalently binds oxidized FAD or its reduced form, hydroquinone (FADH2).

Regrelor is structurally similar to AMP, just like ticagrelor. Regrelor has 4 hydrogen bond donors and 11 acceptors. It is produced as a disodium salt. The two sodium atoms bind the negatively charged phosphate moiety in solution.

Aryloxy propylamine moiety of atomoxetine and reboxetine Atomoxetine contains an aryloxy propylamine moiety that has been linked to monoamine reuptake inhibitory activity. It's selectivity to the norepinephrine transporter (NET) is due to its methyl substituent in the 2’ position on the phenyl ring. Research has shown that a methyl group in position 2’ provides more affinity towards NET than a methoxy group in the same position. The amine group of atomoxetine binds to the amino acids of NET with a salt bridge and hydrogen bonds while the phenyl and methylphenyl groups have hydrophobic interactions.

The Whadjuk formed part of the Noongar language group, with their own distinctive dialect. Culturally they were divided into two matrilineal moieties: Wardungmaat, from wardung ("crow", that is, the Australian raven, Corvus coronoides) and maat ("lineage"; literally "leg") and; Manitjmaat, from manitj ("sulphur-crested cockatoo, Cacatua galerita ") and maat. Moieties were endogamous, and children took the moiety of their mother. Each moiety also contained two "sections" (or "skins"): in the case of the Manitjmaat these were Ballarok and Tondarup and for the Wardungmaat, they were Ngotak and Naganyuk.

In the anthropological study of kinship, a moiety () is a descent group that coexists with only one other descent group within a society. In such cases, the community usually has unilineal descent, either patri- or matrilineal, so that any individual belongs to one of the two moiety groups by birth, and all marriages take place between members of opposite moieties. It is an exogamous clan system with only two clans. In the case of a patrilineal descent system, this can be interpreted as a system in which women are exchanged between the two moieties.

A high number of hydrogen bond acceptors could decrease permeability across the blood–brain barrier (BBB) due to the polar surface area and needs to be taken into account when designing agonists to target α7 nAChRs. Various cyclic amine groups can act as the basic moiety and potency stays relatively unchanged for example aryl piperazine, piperidine and morpholine. An acyclic tertiary amine is tolerated as the basic moiety but larger steric groups are less tolerated. Many derivatives of quinuclidine such as quinuclidine amide are known to be α7 nAChR agonists.

Only the mechanism of CURS1 has been elucidated. In the first step, the feruloyl moiety of feruloyl-CoA is transferred to Cys (164) followed by feruloyldiketide-CoA entering the CoA binding tunnel and being hydrolyzed through an unknown mechanism to a β-keto acid. The acid is then used as an extender substrate in the catalytic triad, where it undergoes decarboxylative condensation with the feruloyl moiety on Cys (164). This mechanism is thought to be identical to that of the decarboxylative condensation of malonyl-CoA in other type III PKSs.

An example of the B component of an AB toxin is Bacillus anthracis protective antigen (PA) protein, B. anthracis secretes three toxin factors: the protective antigen (PA); the oedema factor (EF); and the lethal factor (LF). Each is a thermolabile protein of ~80kDa. PA forms the "B" part of the exotoxin and allows passage of the "A" moiety (consisting of EF or LF) into target cells. PA protein forms the central part of the complete anthrax toxin, and translocates the A moiety into host cells after assembling as a heptamer in the membrane.

FADH2 is bound by a groove between these domains; this binding event causes a loop in the middle domain to change position, preforming a binding site for 4-HPA. At this point, multiple residues act to stabilize catalytic intermediates by hydrogen-bonding to the peroxide bound to FAD, as well as to the hydroxyl group of 4-HPA's phenol moiety (stabilizing its dienone transition state - see Mechanism). The loop which moves to form the 4-HPA binding site when FADH2 binds provides catalytic specificity by hydrogen-bonding to 4-HPA's carboxylic acid moiety.

In addition to the glucose sugar moiety and the β-isomeric aryl substituent the aryl group is composed of a diarylmethylene structure. The synthesis of Gliflozins involves three general steps. The first one is the construction of the aryl substituent, the next one is the introduction of the aryl moiety onto the sugar or glucosylation of the aryl substituent and the last one the deprotection and modification of the arylated anomeric center of the sugar. Phlorizin was the first type of gliflozin and it was non-selective against SGLT2/SGLT1.

It is a natural O-aryl glycoside composed of a d-glucose and an aromatic ketone. However Phlorizin is very unstable, it is rapidly degraded by glucosidases in the small intestines, so it can not be used as an oral administration medication to treat diabetes. Structural modifications have been made to overcome this instability problem. The most efficient way was to conjugate aryl moiety with glucose moiety since C-glucosides are more stable in the small intestines than O-glucoside derivatives (C-C bond instead of C-O-C bond).

Type I pyrethroids lack an alpha-cyano moiety and induce a syndrome consisting of aggressive sparring, altered sensitivity to external stimuli, and fine tremor progressing to whole-body tremor and prostration in rats. These Type I pyrethroid-specific behaviors are collectively described as the T-syndrome. Type II pyrethroids contain an alpha-cyano moiety and produce a syndrome that includes pawing, burrowing, salivation, and coarse tremors leading to choreoathetosis in rats. These Type II pyrethroid-specific behaviors are collectively described as the CS-syndrome (Verschoyle and Aldridge 1980; Lawrence and Casida 1982).

NADK phosphorylates NAD+ at the 2’ position of the ribose ring that carries the adenine moiety. It is highly selective for its substrates, NAD and ATP, and does not tolerate modifications either to the phosphoryl acceptor, NAD, or the pyridine moiety of the phosphoryl donor, ATP. NADK also uses metal ions to coordinate the ATP in the active site. In vitro studies with various divalent metal ions have shown that zinc and manganese are preferred over magnesium, while copper and nickel are not accepted by the enzyme at all.

A manor is defined as a division of countryside, each manor being subject to a Lord who held a manorial court and governed by public law and local custom. In 1379 King Richard II granted licence to give 200 acres of Michaelstowe to the Monastery of Saint Osyth, but following the dissolution of the monasteries by Henry VIII in 1536 the Manor was divided with a "moiety" (half) being granted to Robert Carey, 1st Earl of Monmouth, and a "moiety" to Sir George Whitmore. Sir George Whitmore was Lord Mayor of London in 1631.

EMP, also known as estradiol 3-normustine 17β-phosphate or as estradiol 3-(bis(2-chloroethyl)carbamate) 17β-(dihydrogen phosphate), is a synthetic estrane steroid and a derivative of estradiol. It is an estrogen ester; specifically, EMP is a diester of estradiol with a C3 normustine (nitrogen mustard–carbamate moiety) ester and a C17β phosphate ester. EMP is provided as the sodium or meglumine salt. EMP is similar as a compound to other estradiol esters such as estradiol sulfate and estradiol valerate, but differs in the presence of its nitrogen mustard ester moiety.

The benzocyclobutene moiety has also appeared in a number of chemical compounds with pharmacological properties such as ivabradine and S33005. Additionally, the benzocyclobutene analog of 2C-B has been prepared and a benzocyclobutene-derived amphetamine has been patented.

The cation, which is the active moiety, is called glycopyrronium (INN) or glycopyrrolate (USAN). In June 2018, glycopyrronium was approved by the FDA to treat excessive underarm sweating, becoming the first drug developed specifically to reduce excessive sweating.

Related compounds may be formed by replacing a hydrogen atom with another functional group; the ethane moiety is called an ethyl group. For example, an ethyl group linked to a hydroxyl group yields ethanol, the alcohol in beverages.

Prednylidene is a glucocorticoid for systemic use. Substitution at position 16 also leads to more potent corticosteroids. The additional steric bulk introduced by such substituents adjacent to the dihydroxyacetone side chain also protects that moiety against metabolic degradation.

The term cyclopentenone may also refer to a structural motif wherein the cyclopentenone moiety is a subunit of a larger molecule. Cyclopentenones are found in a large number of natural products, including jasmone, the aflatoxins, and several prostaglandins.

Fulvestrant is a synthetic estrane steroid and a derivative of estradiol. An alkyl-sulfinyl moiety was added to the endogenous estrogen receptor ligand. It was discovered through rational drug design, but was selected for further development via phenotypic screening.

Suxamethonium is a hygroscopic compound. The compound consists of two acetylcholine molecules that are linked by their acetyl groups. It can also be viewed as a central moiety of succinic acid with two choline moieties, one on each end.

Naproxcinoid is metabolized to naproxen and a nitric oxide donating moiety. NO has various cardiovascular effects, including vasodilatory and platelet- inhibitory actions as well as the inhibition of vascular smooth muscle proliferation that serves to maintain normal vascular tone.

Therefore, electron-hole recombination is retarded by the physical separation between the dye–cation moiety and the TiO2 surface, as shown in Fig. 5. Finally, this process raises the carrier diffusion length, resulting in the increase of carrier lifetime.

These are organic compounds containing an benzenesulfonamide moiety with an amine group attached to the benzene ring. The molecular structure is C8H10N2O3S. Its scientific name is N-(4-aminophenyl)sulfonylacetamide. At room temperature, it appears as a white powder.

SRPK2 phosphorylates the serine residues of EVI5L EVI5L has been shown to interact with NUDT18 (nucleoside diphosphate linked moiety X)-type motif 18STRING - Known and Predicted Protein-Protein Interactions NUDT18 and EVI5L interaction and SRPK2 (serine/threonine-protein kinase 2).IntAct: molecular interaction data SRPK2 and EVI5L interaction NUDT18 is a member of the Nudix hydrolase family. Nudix hydrolases eliminate potentially toxic nucleotide metabolites from the cell and regulate the concentrations and availability of many different nucleotide substrates, cofactors, and signaling molecules.GeneCards: NUDT18 (nucleoside diphosphate linked moiety X)-type motif 18 NUDT18 (nucleoside diphosphate linked moiety X)-type motif 18 Function SRPK2 is a Serine/arginine rich protein-specific kinase which specifically phosphorylates its substrates at serine residues located in regions rich in arginine/serine dipeptides, known as RS domains and is involved in the phosphorylation of SR splicing factors and the regulation of splicing.

Propylthiouracil, together with phenylthiocarbamide (PTC), are known to have bitter taste. However, it seems the propensity for tasting these compounds is genetically based and the bitter taste is likely to be engendered by the thiocyanate moiety, also present in PTC.

In 1881 she purchased the second moiety of Rainhill, becoming a very wealthy woman. Bartholomew is buried in the family vault under the church he built, St Bartholomew's in Rainhill.Mosley, Charles, editor. Burke's Peerage, Baronetage & Knightage, 107th edition, vol. 2.

1,1'-Bis(diphenylphosphino)ferrocene, commonly abbreviated dppf, is an organophosphorus compound commonly used as a ligand in homogeneous catalysis. It contains a ferrocene moiety in its backbone, and is related to other bridged diphosphines such as 1,2-bis(diphenylphosphino)ethane (dppe).

Marriage within the same moiety was forbidden. Girls became marriageable at puberty, usually around 12 years of age. Conversely, men were only allowed to marry after the age of 25. Sexual relations were relatively free and uninhibited, regardless of marital status.

The Morning Star Ceremony is a mortuary ceremony of the Dhuwa moiety. In Dhuwa mythology, the Wangarr (Yolngy ancestors) perform the Morning Star Ceremony every night of Venus’ synodic period.ABC Education. (2009). Morning Star Poles tell an artistic story [Video].

Inulin is a heterogeneous collection of fructose polymers. It consists of chain- terminating glucosyl moieties and a repetitive fructosyl moiety,Barclay, Thomas, et al. Inulin – a versatile polysaccharide with multiple pharmaceutical and food chemical uses. Diss. International Pharmaceutical Excipients Council, 2010.

The lactam moiety in benzodiazepams is active towards nucleophiles and numerous analogues have been made by exploiting this fact. Cyprazepam synthesis:; Chem. Abstr., 61: 7,032f (1964). For example, heating demoxepam with N-cyclopropylmethylamine leads to amidine formation, the minor tranquilizer cyprazepam.

A few exceptions exist, however.Posner, H.; Whitten, E.; Sterling, J.; Brunelle, J. Tetrahedron Lett., 1974, 2591. In the example below, conducting the reaction in THF led to transfer of the vinyl moiety, while other solvents promoted methyl transfer. (6)File:VDScope3.

CES1 oxidizes the tertiary amide carbonyl carbons of edoxabans to carboxylic acid groups. CYP3A4 and CYP3A5 oxidize edoxabans via hydroxylation or demethylation. In hydrolysis, 2-amino-5-chloropyridine moiety of edoxaban is removed. Glucuronidation occurs to a lesser extend via glucuronosyltransferases.

Dorothy Djukulul (born 1942) is a traditional Australian Aboriginal artist who lives in Ramingining in Central Arnhem Land. She speaks Ganalbingu and is a part of the Gurrumba Gurrumba clan, who identify as being a part of the Yirrija moiety.

In November 1814, the captain and crew Crocodile received a moiety of the proceeds of the seizure. A first-class share of the distribution, that of Crocodiles captain, was worth £443 17s 0d; a seaman's share was worth £1 15s 9d.

Urolithin A belongs to the class of organic compounds known as benzo-coumarins or dibenzo-α-pyrones. These are polycyclic aromatic compounds containing a 1-benzopyran moiety with a ketone group at the C2 carbon atom (1-benzopyran-2-one).

While Buka will call their moiety categories 'clans' in Tok Pisin and English, this is not sociologically accurate and the word is actually used in two different senses, corresponding to what anthropologists would recognise as moieties and clans. (This is also a feature of the Halia language, the Halia term in question is pinaposa.) There are clans, which trace common descent and will occasionally act as corporate entities. These clans are land-holding groups, though often clans will be represented by sub-clans in different villages, or even in different linguistic areas. By contrast, the moiety classes encompass many different clans.

Figure 1: 24-isopropyl cholestane (left) and 24-n-propyl cholestane (right), two organic molecules produced by sponges and marine algae relevant for studying the evolution of multicellular life in the Precambrian and Phanerozoic. 24-isopropyl cholestane (figure 1, left) is a C30 sterane with chemical formula C30H54 and molecular mass 414.76 g/mol. The molecule has a cholestane skeleton with an isopropyl moiety at C24 and is the geologically stable form of 24-isopropyl cholesterol. A related and important molecule is 24-n-propyl cholestane (figure 1, right), also with the cholestane skeleton, but with an n-propyl moiety at C24.

Due to the higher electronegativity of phosphorus and the polarized nature of the Si=P moiety, phosphasilene tend to react with Lewis acids and bases at the phosphorus atom and silicon atom, respectively. The reaction of phosphasilene with Lewis acids, which usually occurs at the Lewis-basic two-coordinate phosphorus atom, is also dependent upon the nature of the reactants. Lewis bases have been shown to react with both three-coordinate and four-coordinate silicon atoms. The coordination of Lewis bases to the three-coordinate silicon atom of phosphasilene can lead to effective stabilization of the Si=P moiety.

The coenzyme NAD is also consumed in ADP-ribose transfer reactions. For example, enzymes called ADP- ribosyltransferases add the ADP-ribose moiety of this molecule to proteins, in a posttranslational modification called ADP-ribosylation. ADP-ribosylation involves either the addition of a single ADP-ribose moiety, in mono-ADP- ribosylation, or the transferral of ADP-ribose to proteins in long branched chains, which is called poly(ADP-ribosyl)ation. Mono-ADP-ribosylation was first identified as the mechanism of a group of bacterial toxins, notably cholera toxin, but it is also involved in normal cell signaling.

The reaction occurs in the [2Fe] moiety of the active H cluster site, which also includes a [4Fe4S] cluster covalently bonded via a cysteinyl thiolate. An additional accessory site known as the F-domain, which contains four Fe-S clusters, is known as the main gate for electron transfer to and from the catalytic site. The [2Fe] sub-site is coordinated by several CO and CN ligands and an azadithiolate bridge that allows for proton shuttling. The oxidized state of the sub-site, abbreviated as Hox, includes a paramagnetic, mixed-valence [Fe(I)Fe(II)] moiety and a diamagnetic, oxidized [4Fe4S] 2+ cluster.

Balanol is a congener of ATP, with distinct regions of its molecular structure able to form bonds like the adenine ring, ribose, and phosphate groups of the ATP molecule. Specifically, balanol's 4-hydroxybenzamide moiety including the amide linker corresponds to the adenine of ATP, the hexahydroazepane moiety to the ribose region, and the benzophenone rings to ATP's triphosphates. Numerous balanol congeners have been synthesized in order to study the effect of chemical modifications on kinase binding and specificity. For example, modifications of the benzophenone rings, analogs of the phosphate groups of ATP, produce unusually potent and specific protein kinase inhibitors.

Rhamnolipids are a class of glycolipid produced by Pseudomonas aeruginosa, amongst other organisms, frequently cited as the best characterised of the bacterial surfactants. They have a glycosyl head group, in this case a rhamnose moiety, and a 3-(hydroxyalkanoyloxy)alkanoic acid (HAA) fatty acid tail, such as 3-hydroxydecanoic acid. Specifically there are two main classes of rhamnolipids: mono-rhamnolipids and di-rhamnolipids, which consist of one or two rhamnose groups respectively. Rhamnolipids are also heterogeneous in the length and degree of branching of the HAA moiety, which varies with the growth media used and the environmental conditions.

In addition to the syn-configuration of the imino side chain, compared to other third-generation cephalosporins, the more complex moiety (containing two methyl and a carboxylic acid group) confers extra stability to β-lactamase enzymes produced by many Gram-negative bacteria. The extra stability to β-lactamases increases the activity of ceftazidime against otherwise resistant Gram-negative organisms including Pseudomonas aeruginosa. The charged pyridinium moiety increases water-solubility. Ceftazidime shares the same variable R-group side chain with aztreonam, a monobactam antibiotic; the two drugs share a similar spectrum of activity, including activity against Pseudomonas aeruginosa.

It is an 11α-hydroxylated derivative of ethinylestradiol in which a bis(2-chloroethyl)amine nitrogen mustard moiety has been attached as an ester at the C3 position and acetate esters have been attached at the C11α and C17β positions. The mechanism of action of cytestrol acetate in breast cancer is two-fold: (1) acting as an antiestrogen similarly to fulvestrant or ICI-164384; and (2) having cytostatic actions via the carbamate–nitrogen mustard moiety analogously to estramustine phosphate. The drug shows potent efficacy against breast cancer superior to that of tamoxifen in in vitro models.

A perfectly immobile fluorescent moiety when exited with polarized light will emit light which is also polarized. However, if a molecule is moving, it will tend to "scramble" the polarization of the light by radiating at a different direction from the incident light.

Lectins occur ubiquitously in nature. They may bind to a soluble carbohydrate or to a carbohydrate moiety that is a part of a glycoprotein or glycolipid. They typically agglutinate certain animal cells and/or precipitate glycoconjugates. Most lectins do not possess enzymatic activity.

Each wambar chose (from the Keber moiety) one or more delegates with the title of afaliq to represent him in judicial matters. These men traveled the countryside, settling disputes, seeing that the laws were obeyed, and punishing wrongdoing, usually with a fine.

This led to the design of C-region moiety mimicked on RTX, led to compound seen in figure 4b, that showed excellent analgesic activity in mice. An alternative optimization of the lipophilic C region led to JYL1421 (fig. 4c), another promising clinical candidate.

There has also been postulated the existence of LTG4, a metabolite of LTE4 in which the cysteinyl moiety has been oxidized to an alpha-keto-acid (i.e.—the cysteine has been replaced by a pyruvate). Very little is known about this putative leukotriene.

Tilomisole (WY-18,251) is an experimental drug which acts as an immunomodulator and has been studied for the treatment of some forms of cancer. It can also be seen to contain the arylacetic acid moiety that is endemic to many NSAIDs, e.g. ibufenac.

Each moiety was divided into a further two sections. Particular sections (from opposite moieties) were expected to intermarry. The community was also divided into totems, which were also taken into consideration when marriages were being arranged. Particular totemic groups were expected to intermarry.

His speech also gave member of the House the opportunity to raise the issue of his involvement in the Sanborn scandal where large sums of recovered Government money went into private hands. See also the article Anti-Moiety Acts for additional information.

Unit A represents a 4-chlorophenyl group and unit B a 2,4-dichlorophenyl ring. Unit C is the central pyrazole ring and unit D represents the carbonyl group which serves as the hydrogen bond acceptor. Unit E represents a lipophilic aminopiperidinyl moiety.

Publicly derided, the law was partially repealled, but Grant kept his much needed pay raise. Grant's personal reputation remained intact. In 1872, Grant signed into law an act that ended private moiety (tax collection) contracts, but an attached rider allowed three more contracts.

A privileged scaffold is a molecular framework or chemical moiety that is statistically recurrent among known drugs or among a specific array of biologically active compounds. These privileged elements can be used as a basis for designing new active biological compounds or compound libraries.

The yeast and Chinese hamster homologs of this protein catalyze the trimethylation of the histidine residue on elongation factor 2, resulting in a diphthine moiety that is subsequently amidated to yield diphthamide. Multiple transcript variants encoding different isoforms have been found for this gene.

In IUPAC nomenclature, acetyl is called ethanoyl, although this term is rarely heard. The acetyl moiety is a component of many organic compounds, including acetic acid, the neurotransmitter acetylcholine, acetyl-CoA, acetylcysteine, acetaminophen (also known as paracetamol), and acetylsalicylic acid (better known as aspirin).

R. B. Woodward and H. Bickel, (1979); Chem. Abstr., 91, 74633J (1979). This undergoes fragmentation when treated with benzothiazole-2-thiol to give 2. Ozonolysis (reductive work-up) cleaves the olefinic linkage and the unsymmetrical disulfide moiety is converted to a tosyl thioester (3).

The Haida social system changed significantly by the end of the nineteenth century. At this point a majority of the Haida had taken nuclear family forms, and members of families belonging in the same moiety (Ravens and Eagles) were permitted to marry each other.

During the conciliation procedure the members of the commission shall receive honoraria the amount of which shall be established by common agreement by the parties to the controversy. Each of them shall bear its own expenses and a moiety of the joint expenses or honoraria.

Tribromometacresol is an antifungal medication. This compound belongs to the class of organic compounds known as meta cresols, containing a meta cresol moiety which consists of a benzene ring bearing a methyl group and a hydroxyl group at ring positions 1 and 3, respectively.

CGS-20625 is a positive allosteric modulator at several GABAA receptors types. Due to its alicyclic moiety potency at γ1 subunit containing receptor types is more pronounced for CGS-20625 compared to benzodiazepines. γ1 subunits are expressed at higher levels in the central amygdala.

After David's return to Georgia in 1250 and his accession to rule in Imereti, the western moiety of the Georgian kingdom, Dadiani stood by his side. He was responsible for bringing a relative order and stability to his fiefdom of Odishi. He died c. 1260.

A conserved Gln325 polar residue is also involved in hydrogen bonding on the -kynurenine carbonyl group, as well as on the hydrogen on the FAD N3 atom. Arg83 and Tyr97 also form polar contacts with the carboxylate in the amino acid moiety on the substrate.

Even though their undesirable effects are typically lowered, transformation products may remain problematic. Some transformations leave active moiety intact, such as oxidation of thioethers to sulfones and sulfoxides. Parent/transformation product mixtures may have additive effects. Second, some products are more potent than their parents.

A galactosylceramide A galactosylceramide, or galactocerebroside is a type of cerebroside consisting of a ceramide with a galactose residue at the 1-hydroxyl moiety. The galactose is cleaved by galactosylceramidase. Galactosylceramide is a marker for oligodendrocytes in the brain, whether or not they form myelin.

His parents are Claude and Vivian Davidson. Through Claude, he is the grandson of the Haida artist and memoirist Florence Davidson. He is a member of the Eagle moiety, Ts'ał'lanas lineage. His younger brother and former apprentice, Reg Davidson, is also a Haida carver.

1322), by her second husband Nicholas Audley, 1st Baron Audley (d.1316) of Heleigh Castle, Staffordshire. James Audley thus in 1342 inherited his childless aunt Eleanor's moiety of the barony of Barnstaple, giving him possession of the whole, including the constituent manor of Combe Martin.

Regrelor was synthesized from adenosine diphosphate (ADP), an endogenous chemical involved in metabolism. The authors noted that the addition of a lipophilic moiety like cinnamaldehyde at the C-2' and C-3' positions, combined with ethylurea at N-6 on the adenine base, yielded regrelor.

Analytical Biochemistry 119, 450-455. The MTSL moiety will add 184.3 daltons to the mass of the protein or peptide to which it is attached. The cysteine can be introduced using site-directed mutagenesis, and hence most positions in a protein can be labelled.

Leigh married Dorothy, daughter of Edward Shuttleworth of Larbrick, Lancashire, with whom he received a moiety of the manor of Larbrick, afterwards surrendered in payment of a debt owing by Leigh to Serjeant Reginald Bretland. He left no issue. His widow died before 1717.

The Portmore moiety was obtained by William Stevens II in 1888, and most of the Langton moiety by William Stevens III, his son, in 1911. Guildford wharf The Stevens family were connected with the navigation from 1812, when the first William Stevens was employed as the lock- keeper at Trigg Lock. He moved on to Thames Lock in 1820, and then became the wharfinger at Guildford in 1823. He also built up a business as a coal merchant, and was succeeded by his son William Stevens II in 1856. William II became general manager of the Godalming Navigation in 1869, and obtained the Portmore shares in 1888.

It is predicted that the CTP substrate binds much more tightly with viperin because of the low Km value of the substrate. However, the overall structure of both UTP- and CTP-bound compounds are similar. The difference being that the uracil moiety is less effective then the cytosine moiety at binding and ordering turns A and B. Nucleotide-free viperin contains a (βα)6 partial barrel and has a disordered N-terminal extension and a partially ordered C-terminal extension. When the C-terminal tail is ordered, a six-residue α-helix, an eight-residue P-loop (that binds the γ-phosphate of CTP), and a 310-helix are revealed.

Dinogunellins are unusual phospholipids having a nucleotide instead of the typical glycerol in their structure. They consist of an adenine nucleotide, with a 2-aminosuccinimide attached to the phosphorus moiety and a fatty acid attached to the oxygen from either the C2' or the C3' of the sugar moiety. The fatty acid chain could be either the eicosapentaenoic acid (Dinogunellin-A and Dinogunellin-B) or the stearidonic acid (Dinogunellin-C and Dinogunellin-D). In consequence, Dinogunellin-A and Dinogunellin-B have the same molecular formula (C34H49N8O9P) and molecular weight (744.8 g/mol), an so do Dinogunellin-C and Dinogunellin-D (C32H47N8O9P; 718.7 g/mol).

As his father had predeceased his own father, in 1286, Robert inherited the estates of his grandfather, Roger I de Clifford (d.1286). Following the death of his mother, Isabella de Vipont, in 1291, he inherited a one-half moiety of the extensive Vipont feudal barony of Appleby in Westmorland, including Appleby Castle and Brougham Castle. During the outbreak of the Wars of Scottish Independence, in 1296, Brougham Castle became an important military base for Robert, and in 1300, King Edward I of England visited there. In 1308, Robert was granted the remaining moiety of the barony of Appleby, by his childless aunt Idonea de Vipont (d.

Following the Norman invasion of Ireland, the territory of the Gaelic Kingdom of Meath formed the basis for the Anglo-Norman Lordship of Meath granted by King Henry II of England to Hugh de Lacy in 1172. Following the failure of de Lacy's male heirs in 1241, the Lordship was split between two great-granddaughters. One moiety, a central eastern portion, was awarded to Maud (de Geneville) as the liberty of Trim; the other moiety, comprising north-eastern and western portions, went to Maud's sister Margery (de Verdun) and in 1297 became the royal county of Meath. The liberty and royal county were merged in 1461.

The imidazole region: Various substituents have been placed at the para-position of the central phenyl ring. They are electron rich moieties and apparently a positively charged moiety cannot be tolerated in this region of the PDE receptor. There is general agreement about this inhibitor potency: lactam ≥ alkyl-CONH- ≥ imidazoyl = pyridine in place of the central phenyl with its nitrogen in the analogous 4 position ≥ alkyl-S- > simple ether > halide = amine > imidazolium (which is totally inactive). Identification of features common to the most selective inhibitors has led to a "five-point model" with: # Presence of a strong dipole (carbonyl moiety) at one end of the molecule.

Lidocaine has multiple inhibitory actions on the receptor and analysis of the structure of lidocaine has identified the presence of a hydrophobic aromatic ring and a hydrophilic terminal amine. Diethylamine (DEA), a molecule that mimics the hydrophilic moiety of lidocaine by way of a positively charged amine, has been found to block the channel when the receptor is open restricting the flow of Na+ and K+ ions. 2,6-Dimethylaniline (DMA), a molecule that mimics the hydrophobic moiety of lidocaine, has been found to bind the receptor at inter-subunit crevices of the trans-membrane spanning domain thereby causing non-competitive inhibition and restricting the channel from opening.

The myth is closely associated with the importance of moieties and the avoidance practices that go along with them. In Arnhem land, clans are divided into two moieties, Dua, also known as Dhuwa, and Yirritja. According to the story, the sisters only travel through Dua territory, meaning that everything they encountered also share the same moiety. In some versions of the story, there is a strong focus on the pregnancy being a result of an incestuous relation between the elder sister and a Dua clansmen; while they may not be directly related, they share the same moiety which is why the act is frowned upon.

A traditional Athabaskan potlatch is concluded with the giving of gifts. Valuable trade items, traditionally dentalium shells, now largely replaced by rifles, blankets, cash, and beaded items, are collected by the host from members of their mother's moiety and are redistributed by the host to members of his father's moiety in exchange for their contributions of celebration and participation in the potlatch. For instance, an exceptional dancer might be rewarded for her abilities, and likewise a grave digger or pallbearer would be compensated at a funeral potlatch. At the conclusion of a potlatch, gifts are piled high in the center of the meeting hall and distributed to guests.

A reducing end of a carbohydrate is a carbon atom that can be in equilibrium with the open-chain aldehyde (aldose) or keto form (ketose). If the joining of monomers takes place at such a carbon atom, the free hydroxy group of the pyranose or furanose form is exchanged with an OH-side-chain of another sugar, yielding a full acetal. This prevents opening of the chain to the aldehyde or keto form and renders the modified residue non-reducing. Lactose contains a reducing end at its glucose moiety, whereas the galactose moiety forms a full acetal with the C4-OH group of glucose.

DuP-697 was a building-block for synthesis of COX-2 inhibitors and served as the basic chemical model for the coxibs that are the only selective COX-2 inhibitors on the market today. DuP-697 is a diaryl heterocycle with cis-stilbene moiety. Structure activity relationship (SAR) studies for diaryl heterocyclic compounds have indicated that a cis- stilbene moiety and changes in the para-position of one of the aryl rings play an important role in COX-2 selectivity. Celecoxib and parecoxib have a sulfonamide substituent (SO2NH2) in para-position on one of the aryl rings while etoricoxib and rofecoxib have a methylsulfone (SO2CH3).

The idea was first proposed in 1974 by Arieh (later Ari) Aviram, then at IBM, and Mark Ratner, then at New York University. Their publication was the first serious and concrete theoretical proposal in the new field of molecular electronics (UE). Based on the mesomeric effect of certain chemical compounds on organic molecules, a molecular rectifier was built by simulating the pn junction with the help of chemical compounds. Their proposed rectifying molecule was designed so that electrical conduction within it would be favored from the electron-rich subunit or moiety (electron donor) to an electron-poor moiety (electron acceptor), but disfavored (by several electron volts) in the reverse direction.

The core biosynthetic enzymes are thought to include 3 proteins for the biosynthesis of the α-ketopyrrole moiety, 5 for modular type I polyketide synthases for the spiroketal ring, 4 for the biosynthesis of 3-hydroxyanthranilic acid, an N-methyltransferase tailoring enzyme, and a type II thioesterase.

Phosphoramidite: general structure A phosphoramidite (RO)2PNR2 is a monoamide of a phosphite diester. The key feature of phosphoramidites is their markedly high reactivity towards nucleophiles catalyzed by weak acids e.c., triethylammonium chloride or 1H-tetrazole. In these reactions, the incoming nucleophile replaces the NR2 moiety.

St John the Divine Church in Holme Chapel was consecrated in 1794. The Rev. Dr. Thomas Dunham Whitaker would later write that he had contributed more than a moiety toward its construction. The church also contains two 15th century misericords, which probably originated at Whalley Abbey.

He inherited from his father the barony by writ of Botreaux as well as substantial family landholdings which included a moiety of the feudal barony of North Cadbury, Somerset, in the parish church of which capital manor he was buried, as he requested in his will.

The tropane ring system undergoes hydrolysis, SAM-dependent methylation, and reduction via NADPH for the formation of methylecgonine. The benzoyl moiety required for the formation of the cocaine diester is synthesized from phenylalanine via cinnamic acid. Benzoyl-CoA then combines the two units to form cocaine.

The tetravalent moiety CO4 is found in stable organic compounds; they are formally esters of orthocarbonic acid, and therefore are called orthocarbonates. For example, tetraethoxymethane can be prepared by the reaction between chloropicrin and sodium ethoxide in ethanol.Orthocarbonic acid, tetraethyl ester Organic Syntheses, Coll. Vol. 4, p.

It is however possible that, when cytochrome P4501 is the catalyst, oxygenation of the 4-chlorophyl ring occurs. With the S(+) enantiomer it is more likely that oxygenation of the aromatic ring of the 2-phenylpropionic acid moiety occurs, also here is cytochrome P4501 the catalyst.

The Burarra, according to Tindale, consist of five subgroups: # Anbara (western bank of the mouth of the Blyth River) # Marawuraba (from the coast to the east of Blyth River) # Madia (Cape Stewart area) # Maringa # Gunadba (Gunaidbe) Each of the five have a Yirritja/Dua moiety division.

Because of their approximately planar ends, one can estimate the number of functional groups that are in contact with the substrate knowing tube diameter and number of walls which helps in determining single moiety tensile properties. Certainly, this method has obvious implications in tribology as well.

241, note 1 According to Nicholas: "Nothing can with certainty be said of his parents, nor is it positively known whether he left descendants". He may have been a descendant of Reymode de Sully, the son of Walter de Sully, who in 1291 held a fifth moiety of the feudal barony of Great Torrington in Devon, on which he paid feudal relief of £20 to the king, presumably having just then inherited it from his father. The moiety had been first acquired by his ancestor de Sully who had married one of the five sisters and co-heiresses of Matthew de Torrington, feudal baron of Great Torrington.Pole, pp.20-1; co-heiresses of the barony were Matthew's sisters, not daughters as stated by Pole On failure of the male line, this de Sully moiety passed to the de Brian family, by the marriage during the reign of King Henry III (1216-1272) of Guy de Brian to the heiress Sibil de Sully (sister of Raymond de Sully and daughter of Walter de Sully).

From an administrative point of view, the appointment was complicated, involving an anomalous situation comparable to a moiety title. Henry Thursby, later Henry Thursby Pelham, had been rector of Lower Isham since 1825. His resignation in 1839, to take up his father's living at Cound, created the vacancy.

When the azobenzene moiety is in the cis conformation, the amino acid residues align correctly to adopt a β-hairpin formation. However, the trans conformation does not have proper turn geometry for the β-hairpin. This phenomenon can be used to investigate peptide conformational dynamics with femtosecond absorption spectroscopy.

ES-62 has anti-inflammatory effects when subjected to mice. The anti-inflammatory effect occurs because of a phosphorylcholine (PC)-containing moiety and signal transduction. More research needs to be completed; however there is some evidence that Acanthocheilonema vitae may have anti-inflammatory effects, and should be researched further.

The ashes of Iljuwas Bill Reid were buried in Tanu following his death in 1998, near the birthplace of his maternal grandmother, Josephine, of the Kaadaas gaah Kiiguwaay Wolf clan Raven moiety. His headstone joins others that have been placed there by descendants of Tanu chiefs living in Skidegate.

ADP binds behind the NAD-BD, just beneath the pivot helix - the second coenzyme binding site. The adenosine moiety binds down into a hydrophobic pocket with the ribose phosphate groups pointing up toward the pivot helix. ADP can also bind to the second, inhibitory, NADH-site yet causes activation.

Such a reaction could also incur selective and specific electron/moiety transfers. Further, though burning is a reaction that usually involves oxygen (aerobic process), "burning flames" produced by anoxic oxidants are also well-known. Therefore, the enzymes working via murburn scheme (aerobic or anaerobic) could be called murzymes.

Mycophenolate mofetil, a prodrug form of mycophenolic acid used in medicine Mycophenolate mofetil is the morpholino ethyl ester of mycophenolic acid; the ester masks the carboxyl group. Mycophenolate mofetil is reported to have a pKa values of 5.6 for the morpholino moiety and 8.5 for the phenolic group.

Market Cross , Archaeological Data Society. Retrieved 31 January 2007. The manor came into the possession of Henry de Blackburn, who divided it between his two sons. Later, one half was granted to the monks of Stanlow Abbey and this moiety was subsequently granted to the monks of Whalley Abbey.

The Muɹinypata Language of Northern Australia. The Australian National University. In Arabana-Wangkangurru, the speaker will use entirely different sets of pronouns depending on whether the speaker and the referent are or are not in a common moiety. See the following example: See Australian Aboriginal kinship for more details.

The α-β-unsaturated carbonyl moiety in cynaropicrin leads to a drop of intracellular GSH concentration via the Michael reaction. This inhibits the phosphorylation of STAT3 and increases the S-glutathionylation of STAT3 and therefore deactivating it. This leads to an increase in the expression of apoptotic genes.

Arundel formalised his relationship with many of his followers with small grants of land, rather than the annuities characteristic of bastard feudalism. His inquisition post mortem showed that Burley received from him a moiety of Brotton, worth 30s. annually:Calendar of Inquisitions Miscellaneous (Chancery), 1392–1399, no. 236, p. 114.

During times of grief or trouble the Tlingit can call on his father's clan for support at least as much as he can call on his own. His father's clan is not obliged to help him, but the familial connection can be strong enough to alienate two clans in the same moiety. This situation is well documented in oral history, where two clans of opposite moieties are opposed in war—one clan may call upon a related clan of the same moiety for assistance only to be refused because of a father's child among its enemies. The opposition of clans is also a motivator for the reciprocal payments and services provided through potlatches.

Russell married off Isabel de Newmarch to his son Sir Ralph Russell(b.1204), and thus the moiety of the barony of Newmarch containing Dyrham came into the Russell family. The marriage of the other Newmarch heiress, Hawise, seemingly having been sold by Sir John Russell, was acquired by John Botterel, on whose death Hawise married secondly Sir Nicholas de Moels, to which family the other moiety of the barony descended.Wiffen, J.H. Historical Memoirs of the House of Russell from the Time of the Norman Conquest, 1883 The Russell family appear to have resided during the 13th and 14th centuries firstly at Kingston Russell and latterly at Yaverland in the Isle of Wight, Hampshire.

Wollunqua is a totemic ancestor of the Warramunga people, specifically the Uluuru moiety of the tribe. Amongst the Warramunga tribe the snake totems are of considerable importance, the great majority of individuals of the Uluuru moiety belonging either to the Wollunqua, Thalaualla (black snake), or Tjudia (deaf adder) totems; but at the same time the Wollunqua is undoubtedly the most important, and is regarded as the great father of all of the snakes. Wollunqua originated at a certain spot in the Wingara time, and wandered about over the country. He started from the watering hole Kadjinara in the upper part of a rocky gorge in the Murchison Range, and travelled thence away out to the west.

An hydroxymethylglutaryl-CoA synthase cassette (mevalonate pathway) catlyzes the formation of hydroxymethylglutaryl acid by the addition of an malonyl-CoA unit to the terminal ketide of the aceto- acetyl-ACP moiety of ACP1,ACP2, or ACP3. subsequent enzymes, including a unique heme independent halogenase (HaI) catalyze the formation of a cyclopropyl ring. A cysteine specific NRPS module located on CurF follows after cyclopropyl ring formation, and due to the activity of a cyclizing condensation domain, forms a thiazole ring attached to the cylcopropyl moiety from previous reactions in the pathway. Seven standalone PKS modules follow to extend the growing polyketide chain with S-adenosyl methionine (SAM) dependent methylations occurring at positions 10 and 13.

PBPs act on a terminal D-alanyl-D-alanine moiety on a pentapeptide unit and catalyze the formation of a peptide bond between the penultimate D-alanine and a glycine unit on an adjacent peptidoglycan strand, releasing the terminal D-alanine unit in the process. The structure of ceftriaxone mimics the D-alanyl-D-alanine moiety, and the PBP attacks the beta-lactam ring in ceftriaxone as if it were its normal D-alanyl-D-alanine substrate. The peptidoglycan cross-linking activity of PBPs is a construction and repair mechanism that normally helps to maintain bacterial cell wall integrity, so the inhibition of PBPs leads to damage and destruction of the cell wall and eventually to cell lysis.

Resimmune is a bivalent anti-T cell immunotoxin, . The diphtheria toxin moiety has been modified to include an NH2 terminal alanine (A) and two double mutations (dm) have been made to prevent glycosylation in the eukaryotic expression system, Pichia pastoris (Liu et al., 2000; Thompson et al., 2001; Woo et al.

Alternative methods of classification include: method of killing (pore-forming, nuclease activity, peptidoglycan production inhibition, etc.), genetics (large plasmids, small plasmids, chromosomal), molecular weight and chemistry (large protein, peptide, with/without sugar moiety, containing atypical amino acids such as lanthionine), and method of production (ribosomal, post-ribosomal modifications, non-ribosomal).

For IrB3−, vibrational progression from the stretching and breathing vibrations of IrB3 could be assigned in the overlaid spectra of both isomers present in the cluster beam. By comparison to computations, the minimum energy structure of IrB3 could then be formulated as a tetrahedron with an intact, aromatic B3+ moiety.

In a ring-opening SN2-like mechanism, S2 is displaced as a sulfide or sulfhydryl moiety. Subsequent collapse of the tetrahedral hemithioacetal ejects thiazole, releasing the TPP cofactor and generating a thioacetate on S1 of lipoate. The E1-catalyzed process is the rate-limiting step of the whole pyruvate dehydrogenase complex.

Plants in the genus Humulus and Cannabis produce terpenophenolic metabolites, compounds that are meroterpenes.Chapter eight: "Biosynthesis of terpenophenolic metabolites in hop and cannabis". Jonathan E. Page and Jana Nagel, Recent Advances in Phytochemistry, 2006, Volume 40, pp. 179–210, Phenolic lipids are long aliphatic chains bonded to a phenolic moiety.

Diphenoxylate was first synthesized by Paul Janssen at Janssen Pharmaceutica in 1956 as part of a medicinal chemistry investigation of opioids. Diphenoxylate is made by combining a precursor of normethadone with norpethidine. Loperamide (Imodium) and bezitramide are analogs. Like loperamide, it has a methadone-like structure and a piperdine moiety.

Mallojaponin is a hydrolysable tannin found in the bark of Mallotus japonicus. This compound contains the moiety elaeocarpusinic acid, an oxidized hexahydroxydiphenic acid group (dehydrohexahydroxydiphenic acid or DHHDP) which reacted with a dehydroascorbic acid molecule. It also contains a valoneic acid and a gallic acid moieties linked to a glucose molecule.

Lincosamides consist of a pyrrolidine ring linked to a pyranose moiety (methylthio- lincosamide) via an amide bond. Hydrolysis of lincosamides, specifically lincomycin, splits the molecule into its building blocks of the sugar and proline moieties. Both of these derivatives can conversely be recombined into the drug itself or a derivative.

Structure of Atrop-abyssomicin C and Abyssomicin C. Atrop-abyssomicin C has a complex, yet intriguing structural topography. The compound contains an oxabicyclo[2.2.2]octane system fused to the tetronate moiety. The 11-membered macrocyclic ring carries an α,β-unsaturated ketone that was proposed to be the reactive center.

Congress severely condemned Richardson's permissive manner. Grant appointed Richardson judge of the Court of Claims, and replaced him with reformer Benjamin Bristow. In June, Grant and Congress abolished the moiety system. Bristow effectively cleaned house, tightened up the Treasury's investigation force, implemented civil service, and fired hundreds of corrupt appointees.

The nitrogen-centred radical is then free to form a bond with another univalent fragment (X) to produce an N-X bond, where X can be F, Cl, OH, etc. In organic nomenclature, the nitryl moiety is known as the nitro group. For instance, nitryl benzene is normally called nitrobenzene (PhNO2).

Dutasteride, also known as N-[2,5-bis(trifluoromethyl)phenyl]-3-oxo-4-aza-5α-androst-1-ene-17β-carboxamide, is a synthetic androstane steroid and a 4-azasteroid. It is an analogue of finasteride in which the tert-butyl amide moiety has been replaced with a 2,5-bis(trifluoromethyl)phenyl group.

Aminocarb can be broken down by short-wave ultraviolet radiation. Irradiation is often carried out by a high pressure xenon-mercury lamp. Irradiating aminocarb in ethyl alcohol and cyclohexene solutions initially causes the oxidation of the dimethylamine moiety. The process eventually leads to the formation of a 4-dimethylamino-3-methyl phenol product.

A monument to Francis Hall (d.1728) exists in Newton St Cyres Church.Will of Francis Hall of St. James Place, Westminster, Esq., 21 June 1727, with codicil, 30 March 1728 Somerset Archives DD\SF/431 1727-28; Claim to a moiety of certain lands [named] in an unspecified parish in co. Northants.

Lastly, with the introduction of two equivalents of ancillary ligand, the fully open complex is formed where both ligands are bound only through the phosphorus moiety. Importantly, this process is completely reversible in all cases with the addition of appropriate abstraction agents or in some cases by applying vacuum to the system.

On the dried barks, the artists paint sacred designs that belong to themselves or to their clans. They use meticulous layering of individual strokes to produce cross hatched patterns, each pattern belonging to a particular estate, clan, moiety, or place. Rerrkirrwanga often paints stories and patterns related to her husband’s clan Gumatj.

The reaction was discovered in 1907 by the German chemist Hermann Staudinger. The reaction did not attract interest until the 1940s, when the structure of penicillin was elucidated. The β-lactam moiety of the first synthetic penicillin was constructed using this cycloaddition, and it remains a valuable tool in synthetic organic chemistry.

4-HTMPIPO is a synthetic cannabinoid drug first identified in smoking products purchased from online vendors in 2012. 4-HTMPIPO is the product resulting from the electrophilic addition of water to the cyclopropane moiety of synthetic cannabinoid UR-144. Nothing is known about the in vitro or in vivo pharmacology of 4-HTMPIPO.

This model does not account however for the induction observed when catalyst 3 was employed. The current view is that the geometry of the metal center becomes tetrahedral, such that the sterically shielded face of the aldehyde moiety is the Re face. Figure 17. Square planar and tetrahedral Cu (II) stereochemical models.

Xylose is a hemicellulosic sugar found in all angiosperm plants. As such xylose constitutes the second most abundant carbohydrate moiety in nature. Xylose can be produced from wood or agricultural residues through auto- or acid hydrolysis. Ethanol production from such lignocellulosic residues does not compete with food production through the consumption of grain.

All monosaccharide ketoses are reducing sugars, because they can tautomerize into aldoses via an aldol intermediate, and the resulting aldehyde group can be oxidised, for example in the Tollens' test or Benedict's test. Ketoses that are bound into glycosides, for example in the case of the fructose moiety of sucrose, are nonreducing sugars.

The exact arrangement of Yuin kinship before colonisation is not clear, although early ethnographers reported that they did not have a moiety or section system (where a people are split into two or four intermarrying groups). Instead, Yuin kinship would have involved "extensive networks of relatedness within and between exogamous intermarrying country groups".

As a hydroquinone, gentisic acid is readily oxidised and is used as an antioxidant excipient in some pharmaceutical preparations. In the laboratory, it is used as a sample matrix in matrix-assisted laser desorption/ionization (MALDI) mass spectrometry, and has been shown to conveniently detect peptides incorporating the boronic acid moiety by MALDI.

From this research, synthetic endeavours lead to the development of montelukast and zafirlukast as cysteinyl-leukotriene type 1 receptor antagonists. Quinolines were shown to be good moiety for CysLT1 receptor antagonist. From weak antagonistic derivatives of quinolines, montelukast was developed. Several changes to the structure can be made without the loss of activity.

Unstable anions may persist in very rarefied gaseous state, such as in interstellar clouds. Most oxocarbon anions have corresponding moieties in organic chemistry, whose compounds are usually esters. Thus, for example, the oxalate moiety [–O–(C=O)2–O–] occurs in the ester dimethyl oxalate H3C–O–(C=O)2–O–CH3.

Research into the stability of aa-tRNAs illustrates that the acyl (or ester) linkage is the most important conferring factor, as opposed to the sequence of the tRNA itself. This linkage is an ester bond that chemically binds the carboxyl group of an amino acid to the terminal 3'-OH group of its cognate tRNA. It has been discovered that the amino acid moiety of a given aa-tRNA provides for its structural integrity; the tRNA moiety dictates, for the most part, how and when the amino acid will be incorporated into a growing polypeptide chain. The different aa-tRNAs have varying pseudo-first-order rate constants for the hydrolysis of the ester bond between the amino acid and tRNA.

The Louisiana Civil Code article 2589 permits rescission for lesion beyond moiety. It states that the seller may rescind the sale of an immovable when the price, or the property it is exchanged for, is less than one half of the fair market value. Special rules apply to exchanges that have one party exchanging immovable property for a mixture of immovable or movable property, and cash—the party exchanging the mixture of property has the right to rescind the exchange, not the party exchanging the immovable. The Austrian Civil Code §934 also allows the contracting party to rescind for lesion beyond moiety (Verkürzung über die Hälfte) if the rescinding party receives less than half of the fair value of the consideration.

The Djanggawul myth (Originally published 1952) specifically concerned the Dua (Dhuwa) moiety of people, including about a third of the clans that lived in northeast Arnhem Land. The humans born of the two sisters are the ancestors of the Dua clans, the animals the sisters created are the totem animals of those clans, and the places the sisters visited are the clan shrines. The mythology was staged in early contact times by the Dua during several days of dancing, singing, and the manipulation of sacred emblems, on a stage of man-made holes and earth sculpture. The other moiety of the region, the Yirritja (or Yiritja), also participated in the dramatisation of the Djanggawul myth, although some of the rites were accessible only to initiated Dua males.

The Earl built a mansion house at > Colcombe, near Colyton, which was later rebuilt in a more grand state by > Henry Courtenay, but upon his death, the mansion was left in ruins for a > time. It was later restored unto his son, Edward Courtenay, the last earl of > this family, by Queen Mary I of England, and upon his death, was left to > descend to the heirs general, who sold this manor and house. Now the manor > was divided; the one moiety the lord Petre possesseth, the other moiety, Sir > John Pole and Sir John Drake, knights, acquired. Hoskins states that it was first built during the reign of King Edward I of England (1272–1307) by Hugh de Courtenay (1276–1340),Hoskins, p.

The Daklaweidi and Yan Yedi clans are the Wolf Moiety, while the Deisheetaan, Ganaxtedi, Ishkahittaan and Kookhittaan clans are of the Raven Moiety. Each of these six clans select representatives that advise and shape Government policy & processes through various Councils and Teams such as: Elders Council, General Council, Executive Council, Land Use Team, Education Advisory Committee, Family Council, and the Housing Team. C/TFN Government Mission Statement: The Carcross/Tagish First Nation is mandated to protect the environment, health, education and aboriginal rights of our people; to continue to preserve and protect our culture and traditions; to protect and develop our natural resources and strengthen our economy and the government of the Carcross/Tagish First Nation for our future generations.

There is very little formal, modern published information on the mechanism of action of cerberin. Cerberin, as a cardiac glycoside, is seen as binding to and inhibiting the cellular Na+/K+ -ATPase, because it binds to the alpha-subunit of the enzyme. This is the catalytic moiety. There are also a beta- and FXYD subunits.

Multiphoton excitation is a way of focusing the viewing plane of the microscope by taking advantage of the phenomenon where two simultaneous low energy photons are absorbed by a fluorescent moiety which normally absorbs one photon with double their individual energy: say two NIR photons (800 nm) to excite a UV dye (400 nm).

Modified synthesis of the naturally occurring visnagin is reported. Starting from phloroghrcin aldehyde, and building on the 2-methyl-y- pyrone, 2-methyl-5,7-dihydroxy-dfo-yl-chromone was obtained. Construction of the furan moiety was realized by a conventional method through the 7-carboxymethoxy ether giving S-norvisnagin which can be methylated to visnagin.

Center Protonation of the keto moiety (1) is followed by cyclization (2) and dehydration (3), the oxazole ring is less basic that the starting 2-acylamidoketone and so may be readily neutralized (4). Labeling studies have determined that the amide oxygen is the most Lewis basic and therefore is the one included in the oxazole.

CHD1L, a DNA helicase, possesses chromatin remodeling activity and interacts with PARP1/PARylation in regulating pluripotency during developmental reprogramming. The CHD1L macro-domain interacts with the PAR moiety of PARylated-PARP1 to facilitate early-stage reprogramming and pluripotency in stem cells. It appears that CHD1L expression is vital for early events in embryonic development.

Neoeriocitrin is a 7-O-glycoside of the flavanone eriodictyol and the disaccharide neohesperidose (Alpha-L-rhamnopyranosyl-(1->2)-beta-D- glucopyranose). Note that the 'neo' in the name in this case does not refer to the position of the B-ring (which is not in a neo position), but refer to the glycosyl moiety.

The structure of lactosylceramide. The Lactosylceramides, also known as LacCer, are a class of glycosphingolipids composed of a variable hydrophobic ceramide lipid and a hydrophilic sugar moiety. Lactosylceramides are found in microdomains on the plasma layers of numerous cells. Moreover, they are a type of ceramide including lactose, which is an example of a globoside.

Prenol is a building block of isoprenoid alcohols, which have the general formula: :H–[CH2CCH3=CHCH2]n–OH The repeating C5H8 moiety in the brackets is called isoprene, and these compounds are sometimes called 'isoprenols'.See, e.g., . They should not be confused with isoprenol, which is an isomer of prenol with a terminal double bond.

This would be one of the oxocarbon anions, which consist solely of carbon and oxygen. The name would also used for salts containing that anion, and for esters with the [−O−(C=O)5−O−] moiety. Removal of a single proton would result in the monovalent anion hydrogentrioxoglutarate, or HO−(C=O)5−O−.

Photoswitching is the conversion from one chemical isomer to another triggered by light. Photoswitching finds use in optical data processing and storage and in photorelease. Photorelease is the use of light to induce a moiety attached to the nanoparticle surface to detach. UCNPs of lanthanide-doped NaYF4 have been applied as remote control photoswitches.

Quinine (and quinidine) are used as the chiral moiety for the ligands used in Sharpless asymmetric dihydroxylation as well as for numerous other chiral catalyst backbones. Because of its relatively constant and well- known fluorescence quantum yield, quinine is used in photochemistry as a common fluorescence standard.Joseph R. Lakowicz. Principles of Fluorescence Spectroscopy 3rd edition.

Thus the elbow is distal to a wound on the upper arm, but proximal to a wound on the lower arm. This terminology is also employed in molecular biology and therefore by extension is also used in chemistry, specifically referring to the atomic loci of molecules from the overall moiety of a given compound.

2001, 40, 3374-3780.Michael, J.S, Lippard, S. J. Inorganica Chemica Acta 1997,263, 287-299. They represent a new class of molecules with potential to be modified with a chiral moiety and applied to enantioselective reactions.Chenier, P. J.; Halfen, J. A.; Tami L. Autumn E. Rich, R; Splan, K.E.; Yoshioka K; R. Hoye,T.

Isopropylamphetamine is a psychostimulant of the substituted amphetamine class. It is an isomer of propylamphetamine and was discovered by a team at Astra Laekemedel AB.CA 1073913 A2 - Amphetamine Derivatives The isopropyl moiety reduces the stimulant activity of the compound but greatly increases the duration of action. For this reason, the compound is not used recreationally.

Examples of L type ligands that have been studied are amines and phosphines (ref). A ligand exchange reaction in which tributylphosphine ligands were displaced by primary alkylamine ligands on chloride terminated CdSe dots has been reported. Stoichiometry changes were monitored using proton and phosphorus NMR. Photoluminescence properties were also observed to change with ligand moiety.

GGT6 belongs to the gamma-glutamyltransferase (GGT; EC 2.3.2.2) gene family. GGT is a membrane-bound extracellular enzyme that cleaves gamma-glutamyl peptide bonds in glutathione and other peptides and transfers the gamma-glutamyl moiety to acceptors. GGT is also key to glutathione homeostasis because it provides substrates for glutathione synthesis (Heisterkamp et al.

Microcystin-LR is known to be excreted as glutathione conjugate, cysteine conjugate and an oxidized ADDA diene conjugate. The glutathione and cysteine conjugate with the Mda-moiety. The oxidized ADDA is conjugated at the conjugated bond.Kondo, F., Matsumoto, H., Yamada, S., Ishikawa, N., Ito, E., Nagata, S., Ueno, Y.,Suzuki, M. and Harada, K.-I.

Each moiety was composed of five clans or gente, which also had differing responsibilities. Each gens had a hereditary chief, through the male lines, as the tribe had a patrilineal kinship system of descent and inheritance. Children were considered to be born to their father's clan. Individuals married persons from another gens, not within their own.

The addition of Tβγ arrests inhibition of the PDE catalytic moiety because it binds with the Tα-GTP complex. The reassociated form of transducin is not able to bind to PDE any longer. This frees PDE to recouple to photolyzed rhodopsin and return PDE to its initial state to await activation by another GTP bound Tα.

Wild shiso is rich in perilla ketone, which is a potent lung toxin to some livestock. When consumed by cattle and horses, it causes pulmonary edema, leading to a condition sometimes called perilla mint toxicosis. Effects on humans remain to be studied. The plant produces the natural product perilloxin, which is built around a 3-benzoxepin moiety.

RU-58841 can be synthesized either by building the hydantoin moiety or by aryl coupling to 5,5-dimethylhydantoin. RU-58841 produces cyanonilutamide (RU-56279) and RU-59416 as metabolites in animals. Cyanonilutamide has relatively low affinity for the androgen receptor but shows significant antiandrogenic activity in animals. RU-59416 has very low affinity for the androgen receptor.

Minimizing the number of reaction steps and amount of reactive chemicals used leads to a cost- effective and industrially useful reaction. center A more recent biomimetic approach by Shair uses beta-thioketoacids as the nucleophile. The ketoacid moiety is decarboxylated in situ. The process is similar to the way malonyl- CoA is used by Polyketide synthases.

It also has a unique carbohydrate moiety and a unique repetitive amino acid sequence which give it a high affinity for bonding to adhering proteins resulting in a tightening, anti-wrinkle effect. In addition, because of its high molecular weight, it leaves a substantive semi-occlusive film that persists even after washing, and can increase the skins permeability.

Bioleaching involves at least three important subprocesses, viz., attack of the sulfide mineral, microbial oxidation of ferrous iron, and some sulfur moiety. The overall process occurs via one of two pathways depending on the nature of the sulfide mineral, a pathway via thiosulfate resulting in sulfate being formed or a polythionate pathway resulting in the formation of elemental sulfur.

While the phenyl and ethyloxyphenyl groups form hydrophobic interactions. The aryloxy propylamine moiety is also found in many other monoamine reuptake inhibitors, but the placement of substituents on the phenyl ring determine the selectivity. Compounds with substituents in position 2’ have selectivity for NET. Compounds with substituents in position 4’ are selective serotonin reuptake inhibitors e.g.

Karrikins are formed by the heating or combustion of carbohydrates, including sugars and polysaccharides, mainly cellulose. When plant material burns, these carbohydrates convert to karrikins. The pyran moiety of karrikins is probably directly derived from a pyranose sugar. There is no evidence that karrikins occur naturally in plants, but it has been postulated that karrikin-like molecules do.

Digestion is carried out in a vacuole of the parasitic cell. Hemoglobin is composed of a protein unit (digested by the parasite) and a heme unit (not used by the parasite). During this process, the parasite releases the toxic and soluble molecule heme. The heme moiety consists of a porphyrin ring called Fe(II)-protoporphyrin IX (FP).

If Seq1 is higher than 01 it refers to variations of that active moiety. For multi-ingredient records, Seq1=01 identifies a combination of active moieties. If Seq1 is higher than 01 it refers to variations of one or more of the active moieties in the combination. Finally, Seq2 uniquely identifies the name of the record in WHODrug.

Because pyrogens are often difficult to remove, inactivation or destruction of the LPS molecule can sometimes be preferable. ;Acid-base hydrolysis :This method has been shown to cleave Lipid A from the polysaccharide in the LPS molecule (see right). The lipid moiety alone is not soluble in water. Thus unable to bind to endothelial cells, it is rendered inactive.

The enol moiety is methylated with diazomethane, the six- membered ring is closed by reaction with 1,5-diazabicyclo[5.4.0]undec-5-ene (DBU), and the ester protection is removed with trifluoroacetic acid to give 4. The amide side chain is removed by the usual PCl5/dimethylaniline sequence followed by reamidation with the appropriate acid chloride to give cefroxadine (5).

In prokaryotes such as bacteria, diphosphatidylglycerol synthase catalyses a transfer of the phosphatidyl moiety of one phosphatidylglycerol to the free 3'-hydroxyl group of another, with the elimination of one molecule of glycerol, via the action of an enzyme related to phospholipase D. The enzyme can operate in reverse under some physiological conditions to remove cardiolipin.

Aside from protons, other electrophilic groups can attack an acetylene moiety. When attacked by carboxylic acids, cis/trans alkene adducts may be formed. The reaction with hydrogen halides, which also has an initial protonation step, results in the formation of halo-substituted alkenes. Lastly, adamantyl ketones may be formed from an adamantyl cation attack on acetylene and subsequent hydration.

Ethylenedioxy chemical structure. Ethylenedioxy, in chemistry, especially organic chemistry, is a functional group with the structural formula R-O- CH2-CH2-O-R'. It is generally attached to an aromatic ring such as a phenyl, in which case it is called ethylenedioxyphenyl or dihydrobenzodioxine. The ethylenedioxy moiety can be found in the compound EDMA as an example.

Streptomycin is the first-in-class aminoglycoside antibiotic. It is derived from Streptomyces griseus and is the earliest modern agent used against tuberculosis. Streptomycin lacks the common 2-deoxystreptamine moiety (image right, below) present in most other members of this class. Other examples of aminoglycosides include the deoxystreptamine- containing agents kanamycin, tobramycin, gentamicin, and neomycin (see below).

Transglycosylation, which involves the reversible transfer of a sugar moiety from one heterocyclic base to another, is effective for the conversion of pyrimidine nucleosides to purine nucleosides. Most other transglycosylation reactions are low yielding due to a small thermodynamic difference between equilibrating nucleosides.Sugiura, Y.; Furuya, S.; Furukawa, Y. Chem. Pharm. Bull. 1988, 36, 3253. (8)File:NucleoScope4.

Eicosanoid synthesis. (Leukotrienes at right.) Leukotrienes are synthesized in the cell from arachidonic acid by arachidonate 5-lipoxygenase. The catalytic mechanism involves the insertion of an oxygen moiety at a specific position in the arachidonic acid backbone. The lipoxygenase pathway is active in leukocytes and other immunocompetent cells, including mast cells, eosinophils, neutrophils, monocytes, and basophils.

Roburin A is a tannin found in oak wood (Quercus robur and Quercus petraea or Quercus alba) or oak cork (Quercus suber). It is a dimeric compound, composed of two vescalagin subunits probably linked through an ether bond between the diphenoyl group (hexahydroxydiphenic acid or HHDP) of one subunit and the triphenoyl moiety (nonahydroxytriphenic acid) of the other one.

There is a record of a coal pit in 1320. Records show there were fulling-mills in Little Lever before 1559. The holding of Adam Byrom of Salford who died in 1559 was described as "an estate of eight messuages, a moiety of two fulling- mills etc., in Little Lever", his three-year-old grandson Ralph, was his heir.

Gangliosides are present and concentrated on cell surfaces, with the two hydrocarbon chains of the ceramide moiety embedded in the plasma membrane and the oligosaccharides located on the extracellular surface, where they present points of recognition for extracellular molecules or surfaces of neighboring cells. They are found predominantly in the nervous system where they constitute 6% of all phospholipids.

Phages probably evolved to use 5hmC to avoid recogniztion by most restriction enzymes in bacteria. The T4 phage uses 5hmC exclusively during replication, adding glycosylation to the hydroxyl group to further complicate the moiety. Some bacteria have in turn evolved restriction enzymes specific for sites containing 5hmC. One prominent example is PvuRts1I, originally identified in 1994.

The missionary and expert on the Worrorra, J. R. B. Love maintained that the Yawijibaya were being completely assimilated into the Worrorra people by the 1930s, as a clan of the latter's Atpalar moiety. Valda Blundell recorded that in the early 1970s there was still one very old Yawijibaya man from the Montgomery islands resident at the Lombidina mission.

Calendar of Inquisitions Post Mortem, volume 16, no. 1103. It also listed various pieces of land in the vicinity of Kinlet, including a small estate at Catsley. At Leominster an inquisition recorded Brian's moiety of Ashton as held in joint feoffment with his wife Maud, who had survived him.Calendar of Inquisitions Post Mortem, volume 16, no. 1104.

Particularly, grouping and spreading increase the relation of antigen with BCR, thereby proving sensitivity and amplification. On the other hand, pulling forces delinks the antigen from the BCR, thus testing the quality of antigen binding. The receptor's binding moiety is composed of a membrane-bound antibody that, like all antibodies, has a unique and randomly determined antigen-binding site.

Methyl groups in substituent groups R1 and R2 also abolish the potency at norepinephrine and serotonin transporters. Researchers found that replacing one of the ethyl groups of milnacipran with an allyl moiety increases the norepinephrine potency. The pharmacophore of milnacipran derivatives is still largely unclear. The conformation of milnacipran is an important part of its pharmacophore.

Glycine decarboxylase is the P-protein of the glycine cleavage system in eukaryotes. The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha- amino group of glycine through its pyridoxal phosphate cofactor. Carbon dioxide is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.

Scheme 4. Oligonucleotide coupling by phosphotriester method; MMT = -CPh2(4-MeOC6H4). In the 1960s, groups led by R. Letsinger and C. Reese developed a phosphotriester approach. The defining difference from the phosphodiester approach was the protection of the phosphate moiety in the building block 1 (Scheme 4) and in the product 3 with 2-cyanoethyl group.

A silylenoid is a compound that contains R2SiMX (M is metal and R is an organic moiety). Traditionally only lithium, potassium, and sodium could be used. The magnesium silylenoid is synthesized through the addition of magnesium bromide to lithium lithium methyl bromosilylenoid. The magnesium atom replaces the lithium in the complex and has a bromide attached to it.

Biliverdin results from the breakdown of the heme moiety of hemoglobin in erythrocytes. Macrophages break down senescent erythrocytes and break the heme down into biliverdin along with hemosiderin, in which biliverdin normally rapidly reduces to free bilirubin. Biliverdin is seen briefly in some bruises as a green color. In bruises, its breakdown into bilirubin leads to a yellowish color.

It is assumed that the stereochemistry results from the activity of the domains and the absolute configuration is specified by the overall PKS complex. After being released from the thioesterase domain as a long fatty acid chain, the characteristic α,β-unsaturated lactone moiety is formed through a lactonization step to result in the final structure.

In this reform in May it empowered the Congress to legislate on the protection of personal data held by individuals, through the addition of the XXIX-O moiety. The justification for granting that power to the Federal Legislature was that personal data are used in various commercial transactions and trade is regulated at the federal level.

The rhamnose can then be used in the synthesis of rhamnolipids by RhlB and RhlC. The complete pathway of biosynthesis of rhamnolipids has not been confirmed. In summary, mono- and di- rhamnolipids are produced by sequential rhamnosyltransferase reactions catalysed by RhlB and RhlC respectively. The substrate for RhlB is the fatty acid moiety of the detergent, produced by RhlA.

The cleavage is catalysed by a protease within the C-terminal domain. During the reaction a cholesterol molecule is added to the C-terminus of SHH-N. Thus the C-terminal domain acts as an intein and a cholesterol transferase. Another hydrophobic moiety a palmitate is added to the alpha- amine of N-terminal cysteine of SHH-N.

Catechol moieties are also found widely within the natural world. Arthropod cuticle consists of chitin linked by a catechol moiety to protein. The cuticle may be strengthened by cross-linking (tanning and sclerotization), in particular, in insects, and of course by biomineralization. Catechols such as DHSA are produced through the metabolism of cholesterol by bacteria such as Mycobacterium tuberculosis.

The chronicler tells us that Serlo received a moiety of Ockbrook as Margery's dowry. He mentions that, although Serlo had several sons, his co-heirs ultimately were his three daughters, Johanna, Isolda and Agatha. They are also recorded in 1219 as involved in a suit over dower relating to Whittington, a manor within Grendon in Warwickshire. Note anchor 53.

The principal source of the azide moiety is sodium azide. As a pseudohalogen compound, sodium azide generally displaces an appropriate leaving group (e.g., Br, I, OTs) to give the azido compound. Aryl azides may be prepared by displacement of the appropriate diazonium salt with sodium azide, or trimethylsilyl azide; nucleophilic aromatic substitution is also possible, even with chlorides.

San Diego State University Library and Information System. 2009 (retrieved 25 Feb 2009). inhabiting the San Gorgonio Pass eastward to Indian Wells and westward to San Timoteo Canyon. The Nanxaiyem Clan of Augustine Reservation is Coyote moiety. On April 13, 1956, the Commissioner of Indian Affairs approved a census roll of the tribe, documenting 11 living members.

The first clinical trial of mivacurium (BW1090U), in 1984, was conducted in a cohort of 63 US patients undergoing surgical anesthesia. at the Harvard Medical School at Massachusetts General Hospital, Boston, MA. Preliminary data from the study confirmed a promise for this agent to elicit considerably lesser severity of histamine release than that observed with its immediate predecessor clinically tested agents, BW785U77 and BWA444U, which were discontinued from further clinical development. Mivacurium did not exhibit the ultra-short duration of action seen with BW785U; whereas, BW A444U produced an intermediate duration of action. Mivacurium is a biodegradable neuromuscular blocking agent owing to its degradation by plasma cholinesterases - the esterases rapidly hydrolyze one ester moiety initially resulting in a two mono-quaternary metabolites of which one still has an intact ester moiety.

Tlingit soulcatcher, made by Heendei, of the Raven moiety and the Deisheetaan clan. A Soulcatcher or soul catcher (Haboolm Ksinaalgat, 'keeper of breath') is an amulet (Aatxasxw) used by the shaman (Halayt) of the Pacific Northwest Coast of British Columbia and Alaska. It is believed by Tsimshian that all soulcatchers were constructed by the Tsimshian tribe, and traded to the other tribes.

Trost et al. utilized the Bamford–Stevens reaction in their total synthesis of (–)-isoclavukerin to introduce a diene moiety found in the natural product. A bicyclic trisylhydrazone was initially subjected to Shapiro reaction conditions (alkyllithiums or LDA), which only led to uncharacterizable decomposition products. When this bicyclic trisylhydrazone was subjected to strong base (KH) and heat, however, the desired diene product was generated.

Instead, it must bind as bis- quaternary (inter-site). These structures are very dissimilar from acetylcholine and free pipecuronium from nicotinic or muscarinic side-effects linked to acetylcholine moiety. Also, they protect the molecule from hydrolysis by cholinesterases, which explain its nature of kidney excretion. The four methyl-groups on the quaternary N atoms make it less lipophilic than most aminosteroids.

This intermediate then acetylated and subsequently dehydrated to form the exocyclic olefin of the mature tetronate moiety. The intermediate, now containing both the tetronate and trans-decalin motiefs of Maklamicin is then systematically reduced to afford a diene. A second IMDA then occurs between the tetronate and newly formed dienophile to yield the ultimate intermediate which is oxidized to afford Maklamicin.

These prodrugs go through changes in the body leading to carbon–carbon bond between the glucose and the aglycone moiety so c-glucoside are formed from the o-glucosides. C-glucosides have a different pharmacokinetic profile than o-glucosides (e.g. half life and duration of action) and are not degraded by the β-glucosidase. The first discovered c-glucoside was the drug dapagliflozin.

This changes the charge or sterically hinders the antibiotic, decreasing its ribosomal binding affinity. In S. aureus, the best-characterized aminoglycoside-modifying enzyme is aminoglycoside adenylyltransferase 4' IA (ANT(4')IA). This enzyme has been solved by X-ray crystallography. The enzyme is able to attach an adenyl moiety to the 4' hydroxyl group of many aminoglycosides, including kamamycin and gentamicin.

Regio-selective oxidation by GutB1 occurs at the exposed C6 hydroxyl of ADM, pushing a C2-N-C6 cyclization of the resulting 6-oxo intermediate, creating Manojirimycin (MJ). Epimerization of MJ at the C2 position yields the nojirimycin isomer. Nojirimycin is then dehydrated (loss of -OH at C1 position), along with reduction of the imine moiety. This results in the product 1-DNJ.

2-Amino-4-deoxychorismate dehydrogenase (, ADIC dehydrogenase, 2-amino-2-deoxyisochorismate dehydrogenase, SgcG) is an enzyme with systematic name (2S)-2-amino-4-deoxychorismate:FMN oxidoreductase. This enzyme catalyses the following chemical reaction : (2S)-2-amino-4-deoxychorismate + FMN \rightleftharpoons 3-(1-carboxyvinyloxy)anthranilate + FMNH2 This enzyme participates in the formation of the benzoxazolinate moiety of the enediyne antitumour antibiotic C-1027].

It is created by substituting a ketogroup for the cladinose sugar and adding a carbamate ring in the lactone ring. An alkyl-aryl moiety is attached to this carbamate ring. Furthermore, the oxygen at the 6 position is methylated, as is the case with clarithromycin, to achieve better acid-stability. It was patented in 1994 and approved for medical use in 2001.

Several different families of liquid crystals are used in liquid crystals. The molecules used have to be anisotropic, and to exhibit mutual attraction. Polarizable rod-shaped molecules (biphenyls, terphenyls, etc.) are common. A common form is a pair of aromatic benzene rings, with a nonpolar moiety (pentyl, heptyl, octyl, or alkyl oxy group) on one end and polar (nitrile, halogen) on the other.

Albomycins are naturally occurring sideromycins produced by some streptomycetes. The siderophore part of albomycin δ2 is similar to ferrichrome. It contains three molecules of δ-N-hydroxy-δ-N-acetyl ornithine linked to a serine, all by peptide linkage. The C-terminus of the serine is linked to another serine attached to the antibiotically active 4’-thio (N4-carbamoyl-3-methyl) cytidine moiety.

By forming complex ion of bromopyrogallol red and iron(II) compounds, the efficiency of cell can be increased. The lowest transition in the bromopyrogallol have a MLCT character, which greatly increase the electron sensitivity in Iron (II) and thus the complexation of bromopyrogallol ligand with iron(II) bisoxalato moiety was determined to increase the cell efficiency to a higher level.

The overall chemical reaction is: CBGA + O2 \rightleftharpoons THCA + H2O2 tetrahydrocannabinolic acid (THCA), the product of THCA synthase. A hydride is transferred from CBGA to reduce FAD, concerted by deprotonation of a hydroxyl group by a tyrosine residue. The monoterpene moiety in CBGA is then positioned to complete cyclization into THCA. Oxidation of reduced FAD by O2 produces hydrogen peroxide (H2O2).

These residues mediate the hydrolysis of the acetylcholine. The hydrolysis of acethylcholine, catalyzed by cholinesterase at the esteratic site At the esteratic site the acetylcholine is cleaved, which results in a free choline moiety and an acetylated cholinesterase. This acetylated state requires hydrolysis to regenerate itself. Inhibitors like TEPP modify the serine residue in the esteratic site of the cholinesterase.

All rhodopsins consist of two building blocks, a protein moiety and a reversibly covalently bound non-protein cofactor, retinal (retinaldehyde). The protein structure of rhodopsin consists of a bundle of seven transmembrane helices that form an internal pocket binding the photoreactive chromophore. They form a superfamily with other membrane-bound receptors containing seven transmembrane domains, for example odor and chemokine receptors.

The barony was surveyed and divided into lands of equal value, Weymouth taking the eastern moiety and Ferrers the western. However, the survey soon proved to be faulty, and Ferrers' share of lesser value. Weymouth generously deeded a portion of his share to Ferrers to equalize them, a process completed in 1706. Ferrers was admitted to the Privy Council on 25 May 1699.

Estradiol plus the fatty acid valeric acid (valerate) equals estradiol valerate, a C17β ester of estradiol and one of the most widely used estrogen esters. Polyestradiol phosphate, a polymer of estradiol phosphate, the C17β phosphoric acid ester of estradiol. It has on average of 13 repeat units. Estradiol esters have an ester moiety, usually a straight-chain fatty acid (e.g.

The most commonly used biocide, and anti-fouling agent, is the tributyltin moiety (TBT). It is toxic to both microorganisms and larger aquatic organisms. Biocides are also added to pool water, drinking water, and liquid lines for cooling electronics to control biological growth. The prevalence of TBT and other tin-based anti-fouling coatings on marine vessels was a major environmental problem.

Pamela Rae Huteson (born 1957) is an Alaska Native author and illustrator, from Prince of Wales Island in Southeast Alaska. She is both Tlingit and Haida, of the Shungkweidi Eagle moiety, from the Wolf House. Part Owner & DJ of the on-line ThunderCloud Radio, Home of the Hu-Haa Hitz. Featuring Native Hip Hop, Native R&B;, & Native Reggae from Hawaii to Greenland.

IgSF CAMs (Immunoglobulin-like Cell Adhesion Molecules) are cell adhesion molecules that belong to Immunoglobulin superfamily. It is regarded as the most diverse superfamily of CAMs. This family is characterized by their extracellular domains containing Ig-like domains. The Ig domains are then followed by Fibronectin type III domain repeats and IgSFs are anchored to the membrane by a GPI moiety.

After a 4-day period of rest, anticoagulant activity of the saliva is restored. In addition, purified native draculin, obtained from high- and low- activity saliva, shows significant differences in composition of the carbohydrate moiety, and glycosylation pattern. Furthermore, controlled chemical deglycosylation of native draculin progressively leads to complete loss of the biological activity, despite the conditions leaving the polypeptide backbone intact.

Barnumbirr as a Morning Star is a creator spirit in Yolngu culture. Her story is part of the Dhuwa moiety. Yolngu song-lines depict Barnumbirr guiding the Djanggawul sisters as they row a canoe from the mythical island of Bralgu (the home of Wangarr, the Great Creator Spirit) to discover Australia and bring Madayin Law to the Dhuwa people.Gondarra, D. (2011).

Per- and polyfluoroalkyl substances (PFASs, also perfluorinated alkylated substances) are synthetic organofluorine chemical compounds that have multiple fluorine atoms attached to an alkyl chain. As such, they contain at least one perfluoroalkyl moiety, –CnF2n–. According to OECD, there are at least 4730 different PFASs. A subgroup, the fluorosurfactants or fluorinated surfactants, have a fluorinated “tail” and a hydrophilic “head” and are thus surfactants.

Figure 3. Structure activity relationship of the capsaicin related compounds oleovanillamine and phenylacetylrivanyl.Capsaicin (fig. 2) has three functional regions: an aromatic A region where a parent homovanillyl (3-methoxy 4-hydroxybenzyl) group is optimal, a B region known as the ester or amide linker and the aliphatic C region where a lipophilic octanyl moiety is associated with the highest potency.

Monogalactosylceramide is the largest single component of the myelin sheath of nerves. Cerebroside synthesis can therefore give a measurement of myelin formation or remyelination. The sugar moiety is linked glycosidically to the C-1 hydroxyl group of ceramide, such as in lactosylceramide. Cerebrosides containing a sulfuric ester (sulfate) group, known as sulfatides, also occur in the myelin sheath of nerves.

Synthesis of enediyne moiety and convergent assembly: The enediyne is synthesized by 14 enzymes encoded by NcsE to NcsE11 plus NcsF1 and NcsF2. NcsE to NcsE11 constitute another iterative type I PKS, while NcsF1 and NcsF2 have epoxide hydrolase activity. Finally, the building blocks are assembled in a convergent fashion. Ncs6 glycosyltransferase catalyzes the coupling between the enediyne core and the dNDP-deoxyaminosugar.

Roquefortine C contains the unusual E-dehydrohistidine moiety, a system that typically undergoes facile isomerization under acidic, basic, or photochemical conditions to isoroquefortine C, the 3,12 double-bond Z-isomer of roquefortine C. Isomerisation of Roquefortine C to Isoroquefortine C However isoroquefortine C is not a natural product and in contrast to roquefortine C does not bind iron. Both have been synthesised.

TEL-JAK2 is a gene fusion resulting from a chromosomal translocation between chromosomes 9 and 12 observed in human leukemia. The 5' moiety of TEL is fused to the 3' end of JAK2. The oligomerisation domain of the TEL protein (also called ETV6) becomes juxtaposed to the tyrosine kinase domain of JAK2, and as result the TEL-JAK2 displays constitutive kinase activity.

Nascent state or in statu nascendi (Lat. newly formed moiety: in the state of being born or just emerging), is an obsolete theory in chemistry. It refers to the form of a chemical element (or sometimes compound) in the instance of their liberation or formation. Often encountered are atomic oxygen (Onasc), nascent hydrogen (Hnasc), and similar forms of chlorine (Clnasc) or bromine (Brnasc).

The presence of sulfur atom in the heterocyclic ring is hypothesized to enhance potency on VEGFR-2 inhibition. Compounds with thieno [3,2-b] pyridine urea moiety are inhibitory for VEGF receptor signaling and HGF receptor signaling. HGF and HGF receptors undermine the activity of VEGF inhibition. Pyridine derivatives with benzazepine have stronger selectivity and anti-tumor activity and less toxic side effects.

Everolimus has O-2 hydroxyethyl chain substitution and deforolimus has a phosphine oxide substitution at position C-43 in the lactone ring of rapamycin. Deforolimus (Ridaforolimus ) has C43 secondary alcohol moiety of the cyclohexyl group of Rapamycin that was substituted with phosphonate and phosphinate groups, preventing the high- affinity binding to mTOR and FKBP. Computational modelling studies helped the synthesise of the compound.

The structural formula of prymnesin-2 is: C96H136Cl3NO35. The compound has two chiral centers, at the carbon atoms C14 and C85. The molecule is amphoteric, which means that it can act both as base and an acid. This is because all 16 hydroxyls, except for one at C32, are concentrated on carbons C48-84, and there is a xylose moiety at C77.

HIV Gag is then tightly bound to the membrane surface via three interactions: 1) that between the MA HBR and the PI(4,5)P2 inositol phosphate, 2) that between the extruded myristoyl tail of MA and the hydrophobic interior of the plasma membrane, and 3) that between the PI(4,5)P2 arachidonic acid moiety and the hydrophobic channel along the MA surface.

The Yolngu or Yolŋu () are an aggregation of Aboriginal Australian people inhabiting north-eastern Arnhem Land in the Northern Territory of Australia. Yolngu means "person" in the Yolŋu languages. The terms Murngin, Wulamba, Yalnumata, Murrgin and Yulangor were formerly used by some anthropologists for the Yolngu. All Yolngu clans are affiliated with either the Dhuwa (Dua) or the Yirritja moiety.

13 December 2016. There is a specific interaction between pectin and hesperidin through the sugar moieties in the hesperidin molecule. Through acid hydrolysis, the rhamnose and glucose sugar moieties are removed from hesperidin, which breaks the interaction between hesperidin and pectin. Hydrogen bonding plays a role in the specific interaction of neutral sugars of pectin and the sugar moiety of hesperidin.

NBOMe-mescaline, 25G-NBOMe, 2CBFly-NBOMe, 25C-NB3OMe). They differ from the 2C series by the presence of the N-benzyl moiety. Rarely an alpha-methyl group is present making them N-benzyl amphetamines rather than N-benzyl phenethylamines, but this greatly reduces potency and activity. However in some cases where a side chain methyl group is cyclised back to the ring (e.g.

The systematic name of this enzyme class is (R)-S-lactoylglutathione methylglyoxal-lyase (isomerizing glutathione-forming); other names include methylglyoxalase, aldoketomutase, ketone-aldehyde mutase, and (R)-S-lactoylglutathione methylglyoxal-lyase (isomerizing). In some instances, the glutathionyl moiety may be supplied by trypanothione, the analog of glutathione in parasitic protozoa such as the trypanosomes. The human gene for this enzyme is called GLO1.

The methylglyoxal molecule consists of two carbonyl groups flanked by a hydrogen atom and a methyl group. In the discussion below, these two carbonyl carbons will be denoted as C1 and C2, respectively. In both the hemithioacetal substrate and the (R)-S-lactoylglutathione product, the glutathione moiety is bonded to the C1 carbonyl group. The basic mechanism of glyoxalase I is as follows.

The lakinyeri or clans of the Ngarrindjeri were each associated with one or two plant or animal totems, called ngaitji. Totems are sometimes attached to moiety relations (such as in the case of Wangarr relationships for the Yolngu). Torres Strait Islanders have auguds, typically translated as totems. An augud could be a kai augud ("chief totem") or mugina augud ("little totem").

Ubiquitin specific peptidase 9, Y-linked (fat facets-like, Drosophila), also known as USP9Y, is an enzyme which in humans is encoded by the USP9Y gene. It is required for sperm production. This enzyme is a member of the peptidase C19 family and is similar to ubiquitin-specific proteases, which cleave the ubiquitin moiety from ubiquitin-fused precursors and ubiquitinylated proteins.

In 2011, the gene responsible for the behavior was identified. The baculovirus gene (egt) ecdysteroid UDP-glucosyltransferase inactivates the molting hormone (20-hydroxyecdysone(20E)). Specifically, EGT works by transferring a sugar moiety from a nucleotide sugar donor to a hydroxyl group on 20E. By altering the virus, egt was seen as the gene responsible for manipulating the behavior of the larvae.

Ketosamine-3-kinases (KT3K) catalyse the phosphorylation of the ketosamine moiety of glycated proteins. The instability of a phosphorylated ketosamine leads to its degradation, and KT3K is thus thought to be involved in protein repair. The function of the prokaryotic members of this group has not been established. However, several lines of evidence indicate that they may function as fructosamine-3-kinases (FN3K).

Placing a reactive group and a recognizable tag feature on the same molecule using a linker moiety gives an ABP molecule its structure.Schmidinger H., Hermetter A., Birner-Gruenberger R. Activity-based proteomics: enzymatic activity profiling in complex proteomes Amino Acids, 30 (4) 333–350 (2006). The reactive molecule, designed after protease inhibitor mechanisms, lends ABPs their specificity towards targeting active proteases.

Angelicin is the parent compound in a family of naturally occurring organic compounds known as the angular furanocoumarins. Structurally, it can be considered as benzapyra-2-one fused with a furan moiety in the 7,8-position. Angelicin is commonly found in certain Apiaceae and Fabaceae plant species such as Bituminaria bituminosa. It has a skin permeability coefficient (LogKp) of -2.46.

Sulfotransferase enzymes catalyze the sulfate conjugation of many hormones, neurotransmitters, drugs, and xenobiotic compounds. These cytosolic enzymes are different in their tissue distributions and substrate specificities. The gene structure (number and length of exons) is similar among family members. This gene encodes a protein that belongs to the SULT1 subfamily, responsible for transferring a sulfo moiety from PAPS to phenol- containing compounds.

IV, p.377 Effigy of Blanche Bourchier (died 1483), Shirwell Church He married Blanche Bourchier, a daughter of William Bourchier, 9th Baron FitzWarin (1407–1470) of Tawstock, feudal baron of Bampton and heir to a moiety of the feudal barony of Barnstaple, both in Devon. The marriage was childless. She survived him and remarried to Bartholomew St Leger "of Kent".

The European Food Safety Authority assessment had "no safety concern at estimated levels of intake as a flavouring substance". The heterocyclic core of the molecule is readily substituted at the unique methyne centre in the thiazole ring. It is a thermally stable electron-withdrawing moiety with numerous applications in dyes such as thioflavin. Some drugs contain this group, examples being riluzole and pramipexole.

Factors encouraging settlement on the plateau probably included defense.Alconini (2004), pp. 396-401 By the time of the Incas it appears that the Yampara were allied with a number of other Aymara kingdoms in the Charcas confederation. During Inca, and possibly earlier times, and in common with other Andean peoples, the Yampara were organized into an upper and lower moiety.

Breakthroughs, including the success of introducing thioether moiety at C3 of the 2H-indazole structure, has aided in creating drug treatments for a variety of ailments, including cystic fibrosis, with the use of myeloperoxidase inhibitors. Due to the recentness of the discovery of this reaction, though, most research is primarily headed by Haddadin, Kurth, or both, therefore causing a currently limited scope.

On February 18, 1963, the Australian Prime Minister Robert Menzies announced the opening of bauxite mines in the Arnhem Land reserve without consulting Yolngu leaders. Furious at the lack of transparency the Australian government held for the Yolngu people, clan elders came together to paint the famous Yirrkala Church Panels, which documented the Yolngu claim to the land through ancestral stories. Consisting of two four meter tall sheets of masonite, eight elders of the Dhuwa moiety (including Mawalan Marika, Wandjuk Marika and Mithinarri Gurruwiwi) painted one sheet with their major ancestral narratives and clan designs, and eight elders of the Yirritja moiety, including Mungurrawuy Yunupingu, Birrikitji Gumana and Narritjin Maymuru, painted the other sheet with Yirritja designs. This was the first significant political claim to the land by Aboriginal Australians, accompanied by physical documentation in the form of the church panel paintings.

Sedoheptulose 7-phosphate, a pentose phosphate pathway intermediate, is a common precursor of C7N aminocyclitol moiety of natural products, such as acarbose, validamycin A, salbostatin, cetoniacytone A, and pyralomicin 1a. 2-epi-5-epi-valiolone synthase (EEVS), one of the sugar phosphate cyclase family enzyme and which is a homolog of 3-dehydroquinate synthase in shikimate pathway, catalyzes the formation of a common intermediate, 2-epi-5-epi-valiolone from sedoheptulose 7-phosphate. After multiple enzyme reaction steps, which include phosphorylation, epimerization, dehydration, and keto-reduction reactions, valienol, an important core structure is formed which leads to the formation of C7N aminocyclitol containing natural products. In validamycin biosynthesis, the C-N linkage which connect the C7 cyclitol moiety to the other was found to be formed by unprecedented actions of nucleotidyltransferase and glycosyltransferase-like enzymes (which is termed pseudoglycosyltransferase).

John de Ripariis (de Rivers) granted, under the designation of Thomas son of Reginald de Prydyas, Knt., one messuage and one garden in Trurue Marche, with the advowson of the Church of the Blessed Mary of Trurue appertaining to the same garden and house, and one place of land called the Castle, together with the moiety of the free Borough of Trurue Marche with fairs, markets, tolls, stallages, riverage, sac and soc, toll and them, infangenethef, utfangenethef, with all the liberties to the said borough pertaining, &c.;, &c.;, and the services of Thomas Davy for the moiety of the mill which he holds of him in Trureu, to hold to the said Thomas de Pridyas his heirs and assigns of him the said John de Ripariis and his heirs and assigns for ever of the King in capite by the accustomed services.

Arthur had a better reputation than Murphy, but reformers still criticized the patronage structure and the moiety system as corrupt. A rising tide of reform within the party caused Arthur to rename the financial extractions from employees as "voluntary contributions" in 1872, but the concept remained, and the party reaped the benefit of controlling government jobs. In that year, reform-minded Republicans formed the Liberal Republican party and voted against Grant, but he was re-elected in spite of their opposition. Nevertheless, the movement for civil service reform continued to chip away at Conkling's patronage machine; in 1874 Custom House employees were found to have improperly assessed fines against an importing company as a way to increase their own incomes, and Congress reacted, repealing the moiety system and putting the staff, including Arthur, on regular salaries.

Transducin activation ultimately results in stimulation of the biological effector molecule cGMP phosphodiesterase, an oligomer with α, β and two inhibitory γ subunits. The α and β subunits are the larger molecular weight subunits and make up the catalytic moiety of PDE. In the phototransduction system, GTP-bound-Tα binds to the γ subunit of PDE. There are two proposed mechanisms for the activation of PDE.

The recognition moiety is responsible for binding to the analyte in a selective and reversible manner. If the binding sites are 'irreversible chemical reactions,' the indicators are described as fluorescent chemodosimeters, or fluorescent probes. An active communication pathway has to be open between the two moieties for the sensor to operate. In colorimetric chemosensors, this usually relies on the receptor and transducer to be structurally integrated.

SU-8 molecule SU-8 is a commonly used epoxy-based negative photoresist. Negative refers to a photoresist whereby the parts exposed to UV become cross- linked, while the remainder of the film remains soluble and can be washed away during development. As shown in the structural diagram, SU-8 derives its name from the presence of 8 epoxy groups. This is a statistical average per moiety.

In 1839 the area of the mill pond was given as ¾ acre. Charles Whittaker was the owner of the mill in 1842 and by April 1845 Whittaker and Fremlin were joint owners, but by November 1847 the mill had passed back to John Selby. James Fremlin purchased a moiety of the property in October 1871. He purchased the other share in the property in December 1876.

The story of pantoprazole's discovery is a good example of the stepwise development of PPIs. The main focus of modification of timoprazole was the benzimidazole part of its structure. Addition of a trifluoromethyl group to the benzimidazole moiety led to a series of very active compounds with varying solution- stability. In general fluoro substituents were found to block metabolism at the point where they were attached.

Gidansda Giindajin Haawasti Guujaaw, also known as Gary Edenshaw, is a singer, wood carver, traditional medicine practitioner, political activist and leader. He of Gakyaals Kiiqawaay, a Haida family of the Raven moiety. He has currently inherited the name Gidansda from his potlatch in 2017, the title of Gakyaals Kiiqawaay hereditary leader. The family's alternate name, "Skedans", is an anglicized mispronunciation of the family's hereditary leader's title.

In molecular biology, Glycoside hydrolase family 17 is a family of glycoside hydrolases. It folds into a TIM barrel. Glycoside hydrolases are a widespread group of enzymes that hydrolyse the glycosidic bond between two or more carbohydrates, or between a carbohydrate and a non-carbohydrate moiety. A classification system for glycoside hydrolases, based on sequence similarity, has led to the definition of >100 different families.

MDMB-4en-PINACA (also incorrectly known as 5-CL-ADB-A) is an indazole-based synthetic cannabinoid that has been sold online as a designer drug. MDMB-4en- PINACA differs from 5F-MDMB-PINACA due to replacement of 5-fluoropentyl with a pent-4-ene moiety (4-en). It acts as a potent agonist of the CB1 receptor with an EC50 value of 2.47 nM.

The difference between them is the position and number of aryl and hydroxyl substituents plus the absence or presence of an I ring. The I ring seems to be necessary for prolonged tremors to occur. Intermediate metabolites such as terpendoles and paspaline can become lolitrems by addition of two rings (A and B) at the C20-C21 position to the indole moiety of the molecule.

Sir William's grandson married the daughter of Edmund Fitton, who owned the other moiety of the manor which then descended with the Heskeths. In 1339 Sir William Hesketh was granted a charter for a weekly market and annual fair. He fought at the Battle of Crécy in 1346, and was knight of the shire in 1360. In the late 15th century the Heskeths built Rufford Hall.

Australian raven (Corvus coronoides) In Australian Aboriginal mythology, Crow is a trickster, culture hero and ancestral being. In the Kulin nation in central Victoria he was known as Waa (also Wahn or Waang) and was regarded as one of two moiety ancestors, the other being the more sombre eaglehawk Bunjil. Legends relating to Crow have been observed in various Aboriginal language groups and cultures across Australia.

John Bamfielde of Poltimore (son), married Joane de Merton (died 1420),Vivian, p.606 a daughter and co-heiress of Sir Richard de Merton,Vivian, p.38, 606 of Merton, Devon, whose family also inherited a moiety of the feudal barony of Great Torrington. She survived her husband and remarried to Sir John de la Pomeray (1347–1416), feudal baron of Berry Pomeroy, Devon.

Mary married William Gerard (1806–1844) (of the same family who had once owned a moiety of Rainhill) and later Gilbert Stapleton (1808–1856) but had no children. In 1869, she changed her surname to Stapleton-Bretherton. On Bartholomew's death in 1857, Mary inherited his properties. She enlarged Rainhill House renaming it Rainhill Hall (later it was sold to the Catholic Church and renamed Loyola Hall).

In organic chemistry, acetyl is a moiety, the acyl with chemical formula CH3CO. It is sometimes represented by the symbol Ac (not to be confused with the element actinium). The acetyl group contains a methyl group single-bonded to a carbonyl. The carbonyl center of an acyl radical has one nonbonded electron with which it forms a chemical bond to the remainder R of the molecule.

The tRNA(Tyr) molecule has an L-shaped structure. Its recognition involves both subunits of the tyrosyl-tRNA synthetase dimer. The acceptor arm of tRNA(Tyr) interacts with the catalytic domain of one YARS monomer whereas the anticodon arm interacts with the C-terminal moiety of the other monomer. In most YARS structures, the monomers are related to each other by a twofold rotational symmetry.

Photoreceptor proteins typically consist of a protein moiety and a non-protein photopigment that reacts to light via photoisomerization or photoreduction, thus initiating a change of the receptor protein which triggers a signal transduction cascade. Pigments found in photoreceptors include retinal (retinylidene proteins, for example rhodopsin in animals), flavin (flavoproteins, for example cryptochrome in plants and animals) and bilin (biliproteins, for example phytochrome in plants).

Treatment with sodium sesquicarbonate removes copper(II) chlorides from the corroded layer. It is also used as a precipitating water softener, which combines with hard water minerals (calcium- and magnesium-based minerals) to form an insoluble precipitate, removing these hardness minerals from the water.According to cleaning101.com It is the carbonate moiety which forms the precipitate, the bicarbonate being included to moderate the material's alkalinity.

Fig. 2. The WNK4-SPAK/OSR1-NCC phosphorylation cascade. WNK4 phosphorylates and activates SPAK/OSR1, which in turn phosphorylate and activates NCC. In this manner, WNK4 regulates sodium reabsorption in the distal convoluted tubule and downstream potassium secretion through its positive effects on NCC. As a typical kinase, WNK4 accomplishes the phosphorylation of its substrate proteins by adding a phosphate moiety in an ATP-dependent manner.

Bile acid-CoA:amino acid N-acyltransferase is an enzyme that in humans is encoded by the BAAT gene. The protein encoded by this gene is a liver enzyme that catalyzes the transfer of the bile acid moiety from the acyl-CoA thioester to either glycine or taurine, the second step in the formation of bile acid-amino acid conjugates which serve as detergents in the gastrointestinal tract.

Uronium-based peptide coupling reagents Some coupling reagents omit the carbodiimide completely and incorporate the HOAt/HOBt moiety as an aminium/uronium or phosphonium salt of a non-nucleophilic anion (tetrafluoroborate or hexafluorophosphate). Examples of aminium/uronium reagents include HATU (HOAt), HBTU/TBTU (HOBt) and HCTU (6-ClHOBt). HBTU and TBTU differ only in the choice of anion. Phosphonium reagents include PyBOP (HOBt) and PyAOP (HOAt).

His mother, Maria Lucaria Gutierrez, was a member of the Tewa Badger clan (her Tewa name was P'oo kwi tsaawaa). Eduardo and his siblings were raised as members of the Winter moiety of the Santa Clara pueblo. During World War II, Dozier served in the US Army Air Corps in the Pacific theater. At that time he anglicized his name to Edward P. Dozier.

When the charges came, and congress investigated the documents. In the following testimony, Richardson said he didn't read the contracts, he resigned few months later. Sanborn was acquitted of the charges because he was under contract to collect those taxes, but the scandal still rocked the country from January to May 1874. In June 1874, Grant signed the Anti-Moiety Acts, abolishing that system.

Biliatresone is an example of a very rare type of a naturally occurring isoflavonoid-related 1,2-diaryl-2-propenone found in Dysphania glomulifera and D. littoralis. It has been found to cause extrahepatic biliary atresia in a zebrafish model. The enone moiety of biliatresone is particularly reactive, being enhanced by the methylenedioxy, methoxy and hydroxy groups, and undergoes ready Michael addition of water and methanol.

Nucleoside diphosphate-linked moiety X motif 6 is a protein that in humans is encoded by the NUDT6 gene. FGF2 (MIM 134920) is a highly conserved, multifunctional heparin-binding growth factor involved in neuroectoderm development, angiogenesis, and wound healing. Elevated levels of FGF2 are associated with proliferation of smooth muscle in atherosclerosis and with proliferation of tumors. The FGF2 antisense gene, NUDT6, may regulate FGF2 expression.

FOXRED1's structural similarities to sarcosine oxidase (MSOX) predict that tyrosine residues Y410 and Y411 make up the site of covalent attachment of FAD. Additionally, a phenyl moiety at p. 359 is thought to be critical for function. Finally, FOXRED1 is a matrix-directed protein that is thought to be imported through the presence of a mitochondrial membrane potential rather than through a cleavable targeting signal.

Space filling model of phenylpropanolamine. There are four optical isomers of PPA: dextro- and levo-norephedrine, and dextro- and levo-norpseudoephedrine. d-Norpseudoephedrine is also known as cathine, and occurs naturally in Catha edulis ("Khat"). PPA, structurally, is in the substituted phenethylamine class, consisting of a cyclic benzene or phenyl group, a two carbon ethyl moiety, and a terminal nitrogen, hence the name phen-ethyl-amine.

General structures of sphingolipids Cerebrosides is the common name for a group of glycosphingolipids called monoglycosylceramides which are important components in animal muscle and nerve cell membranes. They consist of a ceramide with a single sugar residue at the 1-hydroxyl moiety. The sugar residue can be either glucose or galactose; the two major types are therefore called glucocerebrosides (a.k.a. glucosylceramides) and galactocerebrosides (a.k.a. galactosylceramides).

Erythromycin 3-O-methyltransferase (, EryG) is an enzyme with systematic name S-adenosyl-L-methionine:erythromycin C 3-O-methyltransferase. This enzyme catalyses the following chemical reaction : (1) S-adenosyl-L-methionine + erythromycin C \rightleftharpoons S-adenosyl-L-homocysteine + erythromycin A : (2) S-adenosyl-L-methionine + erythromycin D \rightleftharpoons S-adenosyl-L- homocysteine + erythromycin B The enzyme methylates the 3 position of the mycarosyl moiety of erythromycin C.

Phosphasilenes with significant zwitterionic characters undergoes facile hemolytic cleavage of the fragile Si=P bond. This can be utilized for the liberation and transfer of phosphinidene (:PH) to unsaturated organic molecules. Driess et al. demonstrated that a fragile "half"-parent phosphasilene LSi=PH (L = CH[(C=CH2)CMe(NAr)2]; Ar = 2,6-iPr2C6H3) with highly shielded PH moiety is capable of transferring :PH to NHC.

Though pyridine is an excellent source of carbon, nitrogen, and energy for certain microorganisms, introduction of a halogen moiety significantly retards degradation of the pyridine ring. With the exception of 4-chloropyridine, each of the mono- and di-substituted chloropyridines were found to be relatively resistant to microbiological degradation in soil or liquid media.Sims, G. K. and L.E. Sommers. 1986. Biodegradation of pyridine derivatives in soil suspensions.

The patronage of the church was held in two moieties, one belonging to the Bishop of Norwich and one to Margery de Creke. In 1260 Margery conveyed the messuage and two carucates of land, and her moiety of the advowson, to the priory,Blomefield, 'North Creak', p. 67; Final Concord, 44 Henry III, P.R.O. CP25(1)/214/26 no. 89. View original at AALT.

Methylchloroisothiazolinone, also referred to as MCI, is a preservative with antibacterial and antifungal effects within the group of isothiazolinones. These compounds have an active sulphur moiety that is able to oxidize thiol- containing residues, thereby effectively killing most aerobic and anaerobic bacteria. Methylchloroisothiazolinone is effective against gram-positive and gram-negative bacteria, yeast, and fungi. Methylchloroisothiazolinone is found in many water-based personal care products and cosmetics.

In humans, it activates the bitter taste receptor hTAS2R50. The biphenylcarboxylic acid moiety is biosynthesized by a polyketide-type pathway, with three units of acetyl-CoA and one unit of 3-hydroxybenzoyl-CoA, this being formed from an early shikimate pathway intermediate and not via cinnamic or benzoic acid. It also shows an antileishmanial activity in animal models being an inhibitor of topoisomerase I.

However, Lord Palmerston, the Foreign Secretary, decided that British courts had no jurisdiction and that charges of piracy were not appropriate. He had the 24 men transported to Spain where they stood trial in 1831. The proceeds of the bounty granted for 551 slaves and a moiety of the hull, etc., were deposited in the Registry of the High Court of Admiralty on 16 June 1831.

In 1993, Merck started performing SAR studies of NK1 receptor antagonists, based on both CP-96345 and CP-99994. L-733,060 is one of the compounds that were developed from CP-99994. It has a 3,5-bistrifluoromethyl benzylether piperidine in place of 2-methoxy benzylamine moiety of CP-99994 compound. To improve oral bioavailability, the piperidine nitrogen was functionalized in order to reduce its basic nature.

Yalangbara beach is important as the first site the mythical Djang'kawu sisters reached on the Australian mainland. From Yalangbara they travelled west, establishing the Dhuwa moiety of the Yolŋu people. These stories are described in a 2008 monograph, Yalangbara: art of the Djang'kawu, edited by Margie West and produced in partnership with Banduk Marika and other members of the Rirratjingu clan, and published by Charles Darwin University.

According to the Lysons' Magna Britannia (1822), Hawkridge was inherited in two moieties by the families of Yeo and Chichester and in about 1785 Charles Chichester "of Bath" sold his moiety to the Yeo's.Daniel Lysons and Samuel Lysons, Magna Britannia, Volume 6, Devonshire, London, 1822, Parishes: Cadbury - Clawton, pp. 92–102 Arms of Yeo: Argent, a chevron sable between three ducks azure. Fremington House, near Barnstaple.

Lamplugh, Lois, Barnstaple: Town on the Taw, South Molton, 2002, List of Mayors, p.157 Richard Acland married Susannah Lovering, one of the two daughters and co-heiresses of John Lovering of Hudscott in the parish of Chittlehampton. The other daughter, Dorothy Lovering, whose moiety of her paternal inheritance included Hudscott, married Samuel Rolle, MP, of Hudscott, whom Richard Acland succeeded as MP for Barnstaple.

Peptide nucleic acid (PNA) is a nucleic acid in which natural nucleic acid has been replaced by a synthetic peptide backbone formed from N-(2-amino- ethyl)-glycine units along with sugar phosphate backbone forming in an achiral and uncharged moiety that mimics RNA or DNA oligonucleotides. PNA cannot be degraded inside living cells but it is chemically stable and resistant to hydrolytic (enzymatic) cleavage.

Mass spectrometry of metallocene complexes has been very well studied and the effect of the metal on the fragmentation of the organic moiety has received considerable attention and the identification of metal-containing fragments is often facilitated by the isotope distribution of the metal. The three major fragments observed in mass spectrometry are the molecular ion peak, [C10H10M]+, and fragment ions, [C5H5M]+ and M+.

There are reports that TTR possesses HAT activity and suggest an evolutionary relationship between TTR and other GNAT members. The dipeptide toxin contains tabtoxinine-β-lactam (TβL) linked by a peptide bond to threonine produced, the chlorosis-inducing activity occurs only after hydrolysis of the peptide bond by aminopeptidases of plant or bacterial origin. Cleavage of the peptide bond in tabtoxin releases TβL, the toxic moiety.

Polyadenylation is the covalent linkage of a polyadenylyl moiety to a messenger RNA molecule. In eukaryotic organisms most messenger RNA (mRNA) molecules are polyadenylated at the 3' end, but recent studies have shown that short stretches of uridine (oligouridylation) are also common.Choi et al. RNA. 2012. 18: 394–401 The poly(A) tail and the protein bound to it aid in protecting mRNA from degradation by exonucleases.

Absorption spectrum of ethidium bromide As with most fluorescent compounds, ethidium bromide is aromatic. Its core heterocyclic moiety is generically known as a phenanthridine, an isomer of which is the fluorescent dye acridine. Absorption maxima of EtBr in aqueous solution are at 210 nm and 285 nm, which correspond to ultraviolet light. As a result of this excitation, EtBr emits orange light with wavelength 605 nm.

Cleavage sites of phospholipases. Phospholipase C enzymes cut just before the phosphate attached to the R3 moiety. Phospholipase C (PLC) is a class of membrane-associated enzymes that cleave phospholipids just before the phosphate group (see figure). It is most commonly taken to be synonymous with the human forms of this enzyme, which play an important role in eukaryotic cell physiology, in particular signal transduction pathways.

Figure 3. Fumagillin (green and red) bound to human MetAP2 active site (multicolored, with cyan, purple, and pink corresponding to helices, sheets, and loops, respectively), with dimetal ions (blue) shown. Numerous studies implicate MetAP2 in angiogenesis. Specifically, the covalent binding of either the ovalicin or fumagillin epoxide moiety to the active site histidine residue of MetAP2 has been shown to inactivate the enzyme, thereby inhibiting angiogenesis.

There is also enzymatic degradation of the catecholamines by two main enzymes - monoamine oxidase and catechol-o-methyl transferase. Respectively, these enzymes oxidise monoamines (including catecholamines) and methylate the hydroxal groups of the phenyl moiety of catecholamines. These enzymes can be targeted pharmacologically. Inhibitors of these enzymes act as indirect agonists of adrenergic receptors as they prolong the action of catecholamines at the receptors.

The phenyl ring was moved along the side chain to find its optimal position. These efforts resulted in the two carbon linkers from the polar head group to the phenyl moiety. The resulting product was FTY720 as shown in illustration 2 and its activated, phosphorylated form in illustrations 3a and 3b. Research showed that FTY720 had the same efficacy as ISP-1 in vitro.

Polyketide synthases (PKSs) of fungi are Type I PKSs. Monocerin has been confirmed by biosynthesis studies to have heptaketide origins. Monocerin PKS produces an intermediate with initially a high degree of reductive modification but ends with a classical β-polyketide moiety. Dihydroisocoumarin is the first PKS-free intermediate which would be formed from the reduced heptaketide whose assembly pathway is shown in figure 1.

He thus married off Eva de Braose to his son William III de Cantilupe (d.1254), who thereby inherited the Braose lands,Oxford Dictionary of National Biography, "Cantilupe, William II de (d.1251)" including a moiety of the feudal baron of Totnes. The male line died out on the death of George de Cantilupe (1252–1273) Lord of Abergavenny (son of William III de Cantilupe (d.

Many related compounds are known, although only propiram was ever commercialized. The addition of a 4-phenyl group on the piperidine increases potency by a factor of 133x compared to the parent compound. Addition of a 3,3-dimethyl moiety to the piperidine ring increases potency by 45x compared to the title compound Wollweber H. Stereochemische Untersuchungen über Arzneimittel. European Journal of Medicinal Chemistry 1982; 17: 125–133.

In 1839 the area of the mill pond was given as ¾ acre. Charles Whittaker was the owner of the mill in 1842 and by April 1845 Whittaker and Fremlin were joint owners, but by November 1847 the mill had passed back to John Selby. James Fremlin purchased a moiety of the property in October 1871. He purchased the other share in the property in December 1876.

The acyl carrier protein (ACP) is an important component in both fatty acid and polyketide biosynthesis with the growing chain bound during synthesis as a thiol ester at the distal thiol of a 4'-phosphopantetheine moiety. The ACPs are related in structure and mechanism to the peptidyl carrier proteins (PCP) from nonribosomal peptide synthases. The protein is expressed in the inactive apo form and the 4'-phosphopantetheine moiety must be post-translationally attached to a conserved serine residue on the ACP by the action of holo-acyl carrier protein synthase (ACPS), a 4'-phosphopantetheinyl transferase. 4'-Phosphopantetheine is an essential prosthetic group of several acyl carrier proteins involved in pathways of primary and secondary metabolism including the acyl carrier proteins (ACP) of fatty acid synthases, ACPs of polyketide synthases, and peptidyl carrier proteins (PCP) and aryl carrier proteins (ArCP) of nonribosomal peptide synthetases (NRPS).

Moiety title is a legal term describing a portion other than a whole of ownership of property. The word derives from Old French moitié, "half" (the word has the same meaning in modern French), from Latin medietas ("middle"), from medius.Collins Dictionary of the English Language, 2nd ed., London, 1986 In English law, the term is used in parsing aspects of ownership and liability in all forms of property.

Chemosensors are nano-sized molecules and for application in vivo need to be non-toxic. A chemosensor must be able to give a measurable signal in direct response to the analyte recognition. Hence, the signal response is directly related to the magnitude of the sensing event (and, in turn concentration of the analyte). While the signalling moiety acts as a signal transducer, converting the recognition event into an optical response.

The most powerful chief is called munihil. This chief has in theory power over clans of a moiety class in a district encompassing perhaps several villages. Such a chief will not be the largest and most powerful landholder, and will rarely have a strong genealogical claim over all the villages. Sometimes such a chief will not even be a local, but a preeminent leader drawn from a distant area.

The Ticuna follow the rules of exogamy, in which members of the same moiety are not permitted to marry. In the past, it was common practice for a maternal uncle to marry his niece. Today, however, marriage generally occurs within the same generation. Due to the influence of Catholic missionaries, cross-cousin marriages and polygyny, which were acceptable and common in the past, are no longer viewed as permissible practices.

Spin labelled fatty acids have been extensively used to understand dynamic organization of lipids in bio-membranes and membrane biophysics. For example, stearic acid labelled with nitroxyl spin label moiety at various carbons (5,7,9,12,13,14 and 16th) with respect to first carbon of carbonyl group have been used to study the flexibility gradient of membrane lipids to understand membrane fluidity conditions at different depths of their lipid bilayer organization.

A future nanocar with a synthetic molecular motor has been developed by Jean-Francois Morin et al. It is fitted with carborane wheels and a light-powered helicene synthetic molecular motor. Although the motor moiety displayed unidirectional rotation in solution, light-driven motion on a surface has yet to be observed. Mobility in water and other liquids can be also realized by a molecular propeller in the future.

When the enyne moiety is incorporated into a 10-membered hydrocarbon ring (e.g. cyclodeca-3-ene-1,5-diyne in scheme 2) the reaction, taking advantage of increased ring strain in the reactant, is possible at the much lower temperature of 37 °C. Scheme 2. Bergman reaction of cyclodeca-3-ene-1,5-diyne Naturally occurring compounds such as calicheamicin contain the same 10-membered ring and are found to be cytotoxic.

The C-N=C=N-C core of carbodiimides (N=C=N) is linear, being related to the structure of allene. The molecule has idealized C2 symmetry. The N=C=N moiety gives characteristic IR spectroscopic signature at 2117 cm−1. The 15N NMR spectrum shows a characteristic shift of 275 ppm upfield of nitric acid and the 13C NMR spectrum features a peak at about 139 ppm downfield from TMS.

Elizabeth Peratrovich was born on July 4, 1911 in Petersburg, Alaska, and was a member of the Lukaax̱.ádi clan, in the Raven moiety of the Tlingit nation. She was orphaned at a young age and adopted by Andrew and Mary Wanamaker.Elizabeth Peratrovich 100 Years, Alaska Newspapers, 4 July 2011Andrew J. Wanamaker, Chalyee éesh and Wooshkeenaa, of the Kaagwaantaan clan, Eagle Nest House; Mary Wanamaker; and daughter, Elizabeth Peratrovich.

PDB Entry The chloromethyl group reacts with the active site cysteine to form a covalent bond with the loss of the chlorine. TPCK is chosen for the chemical labelling of active histidine in enzyme analysis. The phenylalanine moiety is bound to the enzyme because of specificity for aromatic amino acid residues at the active site (as in chymotrypsin, in which it binds to the Histidine-57 residue in the active site).

Reg Davidson (born 1954) is an Aboriginal Canadian carver and a member of the Haida band government. He was born in 1954 at the Haida village of Masset on the Queen Charlotte Islands of British Columbia. His parents are Claude and Vivian Davidson and, through Claude, he is the grandson of the Haida artist and memoirist Florence Davidson. He is a member of the Eagle moiety, Ts'ał'lanas lineage.

When Laurdan is located in the cell membrane its emission maximum is centered at 440 nm in gel-phase, and at 490 nm in liquid-phase. This spectral shift is the result of the dipolar relaxation of Laurdan on the lipidic environment, namely, the reorientation of solvents caused by Laurdan’s excitation. Particularly, due to some water molecules located at the level of the glycerol backbone, where the naphthalene moiety residesT.

Acetamiprid is an alpha-Chloro-N-heteroaromatic compound. It is a neonicotinoid with a chloropyridinyl group and it is comparable to other neonicotinoids such as imidacloprid, nitenpyram and thiacloprid. These substances all have a 6-chloro-3-pyridine methyl group but differ in the nitroguanidine, nitromethylene, or cyanoamidine substituent on an acyclic or cyclic moiety. There are two isomeric forms in acetamiprid with E and Z-configurations of the cyanoimino group.

Retentions are used in several other countries. They are common in China, though in some cases the moiety payments are guaranteed by the Agricultural Bank of China. They are also used in the United States where the percentage retained is typically higher at around 10%. However the release of retention is different with 50% of the withheld money often released once the works are considered to be 50% complete.

Theaflavin (TF) and its derivatives, known collectively as theaflavins, are antioxidant polyphenols that are formed from the condensation of flavan-3-ols in tea leaves during the enzymatic oxidation (sometimes erroneously referred to as fermentation) of black tea. Theaflavin-3-gallate, theaflavin-3'-gallate, and theaflavin-3-3'-digallate are the main theaflavins. Theaflavins are types of thearubigins, and are therefore reddish in color. Those molecules contain a tropolone moiety.

Norman Tindale stated that the Dhuwala's lands were basically coextensive with those assigned to the Dhuwal, the two peoples inhabiting the same territory but being distinguished by linguistic differences, moiety type, and clan estate localities. More specifically, he placed them northeast of an imaginary lines linking between Castlereagh Bay and Port Bradshaw, Cape Shield, adding that they also could be found as far south as the Koolatong River.

The hydroxyl moiety of the T residues fits well, when spaced as they are in the internal repeats, with the hydroxyl moieties of externally facing water molecules in the forming ice lattice. This mimics the formation of the growth cone at a nucleation site in the absence of AFPs. Thus, the binding of RiAFP inhibits the growth of the crystal in the basal and prism planes of the ice.

CH—O hydrogen bonding occurs to the stereoelectronically most favorable oxygen lone pair of the BINOL ligand. In such a structure, the top (re) face of the formyl group is much more accessible to a nucleophile attack, as the bottom (si) face is shielded by the neighboring naphthol moiety, thus affording the observed configuration of the product. Figure 13. Transition state proposed for the reaction in Figure 12.

Ammonium ferric citrate has the formula (NH4)5[Fe(C6H4O7)2]. A distinguishing feature of this compound is that it is very soluble in water, in contrast to ferric citrate which is not very soluble. In its crystal structure each citric acid moiety has lost four protons. The deprotonated hydroxyl group and two of the carboxylate groups ligate to the ferric center, while the third carboxylate group coordinates with the ammonium.

Acyclic nucleoside phosphonates prodrugs require further phosphorylation in the cell in order to become the active metabolite. Once PMEG is phosphorylated into its triphosphate form, host or viral DNA polymerases can use it a substrate during DNA synthesis. Since it is an acyclic nucleoside, lacking a 3'-OH moiety, to further extension of the DNA strand occurs. Thus this agent uses the classical mechanism of DNA chain terminator.

Figure 5. Structure-activity relationship of urea derivatives Several capsaicin analogs of the urea type were developed by acylation of homovanillylamine and related amines with different 4-(α-pyridyl)piperidine-1-acyl chlorides. The presence of a polar amino moiety in the hydrophobic C region of capsacinoids was crucial to couple potency and hydrophilicity, mimicking similar observations that led to the discovery of phenylacetylrinvanil (fig. 3b) from olvanil (fig. 3a).

Orbitally, the interactions between transition metals and borylenes tend to be similar to the above Lewis acids and borylenes. A number of computational studies have been performed on these systems. A sample paper from 2000 employed NBO to analyze a series of related complexes. Taking [(CO)4Fe{BN(SiH3)2}] as an example, it was calculated that—as expected—the boron moiety is relatively electron-poor (+0.59 charge).

Pentabromopseudilin, the first reported marine microbial antibiotic, is a bioactive natural product that contains a highly halogenated 2-arrylpyrrole moiety. Pentabromopseudilin (PBP) is a unique hybrid bromophenol-bromopyrrole compound that is made up of over 70% bromine atoms, contributing to its potent bioactivity. PBP was first isolated from Pseudomonas bromoutilis, and has since been found to be produced by other marine microbes, including Alteromonas luteoviolaceus, Chromobacteria, and Pseudoalteromonas spp.

Copper(II) acetate is not necessary in this case because of the high resonance stabilization of the intermediate diphenylmethyl radical.Yang, F. Z.; Trost, M. K.; Fristad, W. E. Tetrahedron Lett. 1987, 28, 1493. (7)File:MnCoupleScope4.png When alkenes or carbonyl compounds containing pendant unsaturated moiety are treated with manganese(III) acetate, tandem intramolecular cyclization reactions may occur. Generally, exo cyclization of terminal double bonds is favored, as shown in equation (10).

Synthesis of deoxyaminosugar moiety: This part is carried out by the enzymes encoded by a cluster of seven genes, named NcsC through Ncs6. Since, these enzymes have similarity to dNDP-D- mannose synthases, it has been proposed that, the synthesis starts from D-mannose-1-phosphate. Since the C-2 hydroxyl group (-OH) is ultimately eliminated, the possibility of having D-glucose-1-phosphate cannot also be ruled out.

Its western moiety, Imereti, of which Odishi was part, had also been fighting its own civil war between the successors of King David Narin—Constantine and Michael. Giorgi Dadiani capitalized on these disorders to assert more autonomy for himself. He, further, seized the duchy of Tskhumi and the Black Sea coastline in Abkhazia up to Anacopia. According to Vakhushti, Giorgi died in 1323 and was succeeded by his son, Mamia I.

This process occurs through an oxidation, which regenerates the pyrrolinium cation and formation of an enolate anion, and an intramolecular Mannich reaction. The tropane ring system undergoes hydrolysis, SAM-dependent methylation, and reduction via NADPH for the formation of methylecgonine. The benzoyl moiety required for the formation of the cocaine diester is synthesized from phenylalanine via cinnamic acid. Benzoyl-CoA then combines the two units to form cocaine.

GTP binding is antagonized by Pi and ADP but is synergistic with NADH bound in the noncatalytic allosteric site. The majority of the contacts between GTP and the enzyme are via the triphosphate moiety. The GTP-binding site is considered to be the "sensor" that turns the enzyme off when the cell is at a high energy state. GTP binds at the junction between the NAD-BD and the antenna.

HSAN ID is caused by heterozygous missense mutations in the ATL1 gene which encodes atlastin-1. Atlastin-1 is a member of the dynamin/Mx/guanylate-binding protein superfamily of large GTPases. The enzyme contains an endoplasmic reticulum (ER) retention moiety, indicating that it functions predominantly in the organelle. It is highly expressed in the mammalian central nervous system and is enriched in the hippocampus and pyramidal neurons.

Controlled radical polymerization, namely reversible addition−fragmentation chain-transfer polymerization (RAFT), is a common method for the polymerization of acrylates, methacrylates and acrylamides. Usually, a thiocarbonate is used in combination with an effective initiator for RAFT. The thiocarbonate moiety can be functionalized at the R-group for end group analysis. The end group is a result of the propagation of chain- transfer agents during the free-radical polymerization process.

TcdA glucosylates RhoA by transferring a glucose molecule from UDP-glucose, a nucleotide sugar, to Thr-37 of the RhoA GTPase. In Rac and Cdc42, the sugar moiety is transferred to the Thr-35. The glucosylation prevents proper binding of GTP and blocks activation. TcdA acts preferentially on the GDP-bound form of the GTPase proteins since this configuration exposes the threonine residue that is glucosylated by the toxin.

Enantioselective benzylic functionalization methods use the complexed chromium tri(carbonyl) moiety essentially as a chiral auxiliary.Uemura, M.; Hayashi, Y.; Hayashi, Y. Tetrahedron: Asymmetry, 1993, 4, 2291. Approach of the functionalizing reagent anti to the ----chromium tri(carbonyl) fragment leads to a single diastereomer of the product complex. After removal of the chromium group with lightMishchenko, O. G.; Klementeva, S. V.; Maslennikov, S. V.; Artemov, A. N.; Spirina, I. V. Rus.

5CB is produced by modifying biphenyl in a linear manner. First Br2 is added to the biphenyl to introduce a bromine atom to the end of the moiety. Next aluminium chloride and C4H9COCl is added to the sample, followed by the addition of potassium hydroxide and NH2NH2. By this point the molecule will have a bromine atom on one end of the rigid core and C5H11 on the other end.

Mathews noted that marriage rules similar to those of the Kamilaroi occurred across much of Australia. Some communities had intermarrying moieties without further divisions within the moiety groups. Others had moieties divided into four sections (now known as sub-sections). He plotted the distribution of marriage rules and other cultural traits in his "Map Showing Boundaries of the Several Nations of Australia", published by the American Philosophical Society in 1900.

A galactoside is a glycoside containing galactose. The H of the OH group on carbon-1 of galactose is replaced by an organic moiety. Depending on whether the glycosidic bond lies "above" or "below" the plane of the galactose molecule, galactosides are classified as α-galactosides or β-galactosides. A β-galactoside is a type of galactoside in which the glycosidic bond lies above the plane of the galactose residue.

The disadvantages of the reaction involve side reactions of the carbene moiety. The choice of solvent for the reaction needs to be considered. In addition to the potential for carbon-hydrogen bond insertion reactions, carbon-halogen carbene insertion is possible when dichloromethane is used as the solvent. C-Cl bond insertion Control for regioselectivity during the carbene addition is necessary to avoid side products resulting from conjugated cycloheptatriene isomers.

Nicotinamide adenine dinucleotide consists of two nucleosides joined by a pair of bridging phosphate groups. The nucleosides each contain a ribose ring, one with adenine attached to the first carbon atom (the 1' position) and the other with nicotinamide at this position. The nicotinamide moiety can be attached in two orientations to this anomeric carbon atom. Because of these two possible structures, the compound exists as two diastereomers.

The Hopi-Tewa are related to the Tewa communities living in the Rio Grande Valley, such as Santa Clara Pueblo and Ohkay Owingeh. The long contact with Hopi peoples has led to similarities in social structure with their kinship system and their organization to clans being almost identical with the Hopi (the other Tanoan Pueblo groups do not have clans). However, the Tewa dual moiety has been preserved.

The character of the backbone chain depends on the type of polymerization: in step-growth polymerization, the monomer moiety becomes the backbone, and thus the backbone is typically functional. These include polythiophenes or low band gap polymers in organic semiconductors. In chain-growth polymerization, typically applied for alkenes, the backbone is not functional, but bears the functional side chains or pendant groups. The character of the backbone, i.e.

The Tsimshian are one of the largest First Nations peoples in northwest British Columbia. Some Tsimshian migrated to Annette Island, Alaska, and today approximately 1,450 Alaska Tsimshian people are enrolled in the federally recognized Metlakatla Indian Community, sometimes also called the Annette Island Reserve. Tsimshian society is kinship-based and matrilineal, so clans and property pass through the maternal line. Their moiety-based societal structure is further divided into clans.

David VII, also known as David Ulu () (1215–1270), from the Bagrationi dynasty, was king of Georgia from 1247 to 1270, jointly with his namesake cousin, David VI, from 1247 to 1259, when David VI, revolting from the Mongol hegemony, seceded in the western moiety of the kingdom, while David VII was relegated to the rule of eastern Georgia. During his reign, Georgia went into further decline under the Mongol overlordship.

Cordycepin, or 3'-deoxyadenosine, is a derivative of the nucleoside adenosine, differing from the latter by the absence of the hydroxy group in the 3' position of its ribose moiety. It was initially extracted from the fungus Cordyceps militaris, but can now be produced synthetically. It is also found in other Cordyceps species as well as Ophiocordyceps sinensis. Because cordycepin is similar to adenosine, some enzymes cannot discriminate between the two.

In method of action, the preparation is exactly identical to that of caffeine base as the citrate counter ion dissociates in water. Doses of caffeine citrate, due to the added weight of the citrate moiety, are understandably higher than with caffeine base, i.e., it takes a larger dose to get the same amount of caffeine. The ratio of therapeutic doses of caffeine base to its citrate salt is typically 1:2.

Related to this theory is the idea that Honored status was not a class or a clan, but a title. Sun status, likewise, may not have been a class but rather a term for the royal family. If true, Natchez society would have been a moiety of just two groups, commoners and nobles. The requirement of exogamy may have applied to Suns only, rather than the entire nobility.

It catalyses AMPylation of Rho GTPases in eukaryotic cells and therefore induces the collapse of the actin cytoskeleton. Doc (death on curing) protein is also part of a toxin-antitoxin module Phd-Doc from prophage P1. Doc toxin uses inverted substrate and catalyses phosphorylation instead of transferring NMP moiety. Doc phosphorylates elongation factor EF-Tu and locks it in an unfavorable open conformation to bind tRNAs and therefore blocks protein translation.

Despite being a strained macrocycle, there exist an atropisomer, abyssomicin C. The atropisomerism arise due to a structural deviation in the α,β-unsaturated ketone region of the molecule. The orientation of the carbonyl in atrop- abyssomicin C is cisoid, whereas the conformation in abyssomicin C is transoid. The enone moiety of atrop-abyssomicin C has a higher degree of the conjugation, which makes it a more active Michael acceptor.

This releases fructose and forms a sugar-enzyme intermediate when the glucose unit attaches to the nucleophile. The second displacement is transfer of a glucosyl moiety to an acceptor, such as a growing glucan chain. The debate in the past was over whether the glucosyl group attached to the non-reducing or reducing end of an incoming acceptor. Additional investigations pointed to a non-reducing mechanism with a single active site.

Immunoglobulin superfamily CAMs (IgSF CAMs) is regarded as the most diverse superfamily of CAMs. This family is characterized by their extracellular domains containing Ig-like domains. The Ig domains are then followed by Fibronectin type III domain repeats and IgSFs are anchored to the membrane by a GPI moiety. This family is involved in both homophilic or heterophilic binding and has the ability to bind integrins or different IgSF CAMs.

William A. Richardson President Ulysses S. Grant signed a series of laws during his first and second terms that limited the number of special tax agents and prevented or reduced the collection of delinquent taxes under a commissions or moiety system. The public outcry over the Sanborn incident caused the Grant administration to abolish the practice of appointing special treasury agents to collect commissions or moieties on delinquent taxes.

The desired product of a RAFT polymerization is typically linear polymer with an R-group at one end and a dithiocarbonate moiety at the other end. Figure 4 depicts the major and minor products of a RAFT polymerization. All other products arise from (a) biradical termination events or (b) reactions of chemical species that originate from initiator fragments, denoted by I in the figure. (Note that categories (a) and (b) intersect).

Mithinarri Gurruwiwi was born in 1929 to the Galpu clan and the Dhuwa moiety in the Blue Mud Bay area of Northeast Arnhem Land. The Galpu clan is known to play the yidaki or didgeridoo. Besides Yirrkala, the Galpu clan also lives at Galiwinku, Goulburn Island, Gunyungarra, Gangan and Galupa. Another John Mandjuwi Gurruwiwi is another respected Galpu artist whose work is held in the National Gallery of Australia.

D1 and D2 receptors interact primarily through discrete amino acids in the cytoplasmic regions of each receptor, with no involvement of transmembrane parts. The intracellular loop 3 of the D2 receptor contains two adjacent arginine residues, while the carboxyl tail of the D1 receptor possesses two adjacent glutamic acid residues. The two receptors can form a heteromer complex via a salt bridge between the guanidine moiety and the carboxylic group.

Mawalan Marika was born in 1908 in Yirrkala. His clan falls under the Dhuwa moiety, one of the two moieties found in Arnhem Land. In addition to being an important asset to many anthropologists including Charles P. Mountford and Ronald Berndt, he was one of the most prominent political activists of his time. Marika was a signatory of the Yirrkala bark petitions sent to the Australian government in 1963.

SAR: Preparation of the pyridylpiperazine moiety starts by aromatic displacement of chlorine from 2-chloro-3-nitropyridine by piperazine to give 3. The secondary amine is then protected as its BOC derivative by reaction with di-tert-butyl dicarbonate (Boc anhydride) to give 4. The nitro group is then reduced by catalytic hydrogenation. Reductive alkylation with acetaldehyde in the presence of lithium cyanoborohydride gives the corresponding N-ethyl derivative.

At the low end are the dipeptides. The most important drugs with a dipeptide (L-alanyl-L-proline) moiety are the “-pril” cardiovascular drugs, such as Alapril (lisinopril), Captoril (captopril), Novolac (imidapril) and Renitec (enalapril). Also the artificial sweetener Aspartame (N-L-α-Aspartyl-L- phenylalanine 1-methyl ester) is a dipeptide. At the high end there is the anticoagulant hirudin, MW ≈ 7000, which is composed of 65 amino acids.

These results suggest that hydrophobicity around the spiroketal moiety of aplog-1 would enhance antiproliferative activities but not tumor-promoting activity. The antiproliferative activities of the analogs to not simply depend on molecular hydrophobicity, and the local hydrophobicity around position 10 plays an important role in enhancing antiproliferative activities. Because the analogues possess the skeleton of tumor-promoting aplysiatoxin and debromoaplysiatoxin, the adverse effects would be most likely tumor promotion.

Figure 1. Tirandamycin family of structures Figure 2. Biosynthetic pathway of tirandamycins Figure 3. TrdL in vitro activity Figure 4. TamI and TamL post- translational modifications The tirandamycins are a small group of natural products that contain a bicyclic ketal system and a tetramic acid moiety, the latter of which is found in different natural products from a variety of sources and which is characterized by a 2,4-pyrrolidinedione ring system.

The Gulidjan are a matrilineal society who intermarried with the Djab Wurrung, Djargurd Wurrung and Wada wurrung. Each person belonged to a moiety of gabadj (Black Cockatoo) or grugidj (White Cockatoo). At interregional corroborees, where upwards of 20 tribes each having its own language or dialect, would gather, Gulidjan was one of four languages spoken, the other three being Tjapwurrung, Kuurn Kopan Noot and Wiitya whuurong, a dialect of Wathawurrung.

Guaianolides are known to exhibit significant biological activity. The plants containing such compounds have been a source for traditional medicine to treat a wide variety of ailments such ranging from rheumatic pain, pulmonary disorders, and increasing bile production. It is generally believed that the α-methylene-γ-lactone moiety is the functional group responsible for the biological activity in guaianolides due to its interaction with biological nuecleophiles. In 2004, Zhangabylov et.

Dioxosuccinic acid or dioxobutanedioic acid is an organic compound with formula C4H2O6 or HO−(C=O)4−OH. Removal of two protons from the molecule would yield the dioxosuccinate anion, or −O−(C=O)4−O−. This is one of the oxocarbon anions, which consist solely of carbon and oxygen. The name is also used for salts containing that anion, and for esters with the [−O−(C=O)4−O−] moiety.

Exogenous NO sources constitute a powerful way to supplement NO when the body cannot generate enough for normal biological functions. Certain endogenous compounds can act as NO-donors or elicit NO-like reactions in vivo. Nitroglycerin and amyl nitrite serve as vasodilators because they are converted to nitric oxide in the body. The vasodilating antihypertensive drug minoxidil contains an ·NO moiety and may act as an NO agonist.

The Lord Constable of Ireland, originally vested with lands to which it was incident or annexed, and which descended through Walter's son Gilbert de Lacy to John de Verdun (ex jure uxoris Margaret) by virtue of his moiety of Meath (the other moiety descending to Geoffrey de Genneville, ex jure uxoris Matilda). By 1460, the lands to which it had been incident vested in Lord Theobald de Verdun's co-heirs in 1460, and, according to Lynch, the exercise of the office fell into desuetude. However, it can be seen elsewhere that the Lord High Stewardship continued to be inherited by the Earls of Shrewsbury. In Letters of Appointment dated 27 August in the 28th year of King Henry VI, the first Earl of Shrewsbury who was also the Lord High Steward or Great Seneschal of Ireland, appointed John Penyngton to be Steward of the Liberty of Waterford, and in such appointment, the Earl is described as "Senescallus ac Constabularius Hiberniae".

Bound balanol extends 17.2 Å from the hydroxyl oxygen atom of its 4-hydroxybenzamide to the most distal carboxyl oxygen atom of its benzophenone moiety, fitting between the large and small catalytic lobes of PKA and extending from the inner edge to the outer mouth of the active-site ATP-binding cleft of the enzyme. The cleft's glycine-rich loop and small lobe allow for tight, induced-fit binding. Each subsite of the ATP-binding pocket in PKA is occupied by a substituent of the balanol molecule as observed in studies of recombinant mouse catalytic subunit of PKA. The adenine subsite of PKA has hydrophobic components and has the potential to donate and accept electrons to make hydrogen bonds with one or two planar cyclic rings. Specifically, the backbone nitrogen of Val123 and the carbonyl oxygen atom of Glu121 can form hydrogen bonds with balanol's single hydroxyl group of the 4-hydroxyl benzoyl moiety.

Saga'wan), a story (adaawak in Nisga'a) of the origin of the Gitxon people which records their arrival on the Queen Charlotte Islands, homeland of the Haida, where the Gitxon Eagles came to form one moiety of a village while the people of Qoona formed another. This story tells of Gitxon's niece Dzilakons (variously spelled) and her engagement with a prince of the opposite moiety which led to a war between the two sides, spurring the Gitxon people's migration to the Nisga'a homeland on the Nass River, to the Tsimshian villages of Kitkatla and Kitsumkalum, and to the Cape Fox (in Nisga'a Laxsee'le) tribe of Tlingits in what is now Alaska. Other versions of Gitxon migrations tell of movements from the Charlottes to the Nass, from the Nass to the Charlottes and back again, from Kitsumkalum to the Charlottes and back again, or from Kitselas to Kitamaat to the Charlottes and back again. The Charlottes and Alaska both arise as possible originary points for this group.

Structural features which are highly necessary for function are subjected to strong conservation pressure, while regions distant from the active site undergo genetic drift. This can lead to the specialization or differentiation of function arising from modification of an enzymatic core moiety. For example, the closely related thyroid peroxidase catalyzes a specific oxidation reaction in the biosynthesis of a hormone, while other heme peroxidases fulfill roles in immune defense and redox signalling.

In molecular biology, glycoside hydrolase family 27 is a family of glycoside hydrolases. Glycoside hydrolases are a widespread group of enzymes that hydrolyse the glycosidic bond between two or more carbohydrates, or between a carbohydrate and a non-carbohydrate moiety. A classification system for glycoside hydrolases, based on sequence similarity, has led to the definition of >100 different families.Bairoch, A. "Classification of glycosyl hydrolase families and index of glycosyl hydrolase entries in SWISS-PROT". 1999.

Raven Tales are unique to Tlingit culture. Although the tales are associated with the Raven moiety, most are shared by any Tlingit regardless of clan affiliation and make up of the stories told to children. Raven Cycle stories are often shared anecdotally, the telling of one inspiring the telling of another. Many are humorous; some are serious, imparting Tlingit morality and ethics, and others belong to specific clans and may only be shared with permission.

Roskell et al, BURLEY, John I (d.1415/16), of Broncroft in Corvedale, Salop. – Author: L.S. Woodger Burley had also held the wardship of Robert Corbet, the heir of Sir Roger and nephew of Joan. Darras could not entirely escape penalty when in 1406 he and Roger Willey bought two properties held in capita without obtaining royal approval: a quarter carucate of land at Worfield and a moiety of the forestership of Morfe.

In molecular biology, glycoside hydrolase family 97 is a family of glycoside hydrolases. Glycoside hydrolases are a widespread group of enzymes that hydrolyse the glycosidic bond between two or more carbohydrates, or between a carbohydrate and a non-carbohydrate moiety. A classification system for glycoside hydrolases, based on sequence similarity, has led to the definition of >100 different families.Bairoch, A. "Classification of glycosyl hydrolase families and index of glycosyl hydrolase entries in SWISS-PROT". 1999.

In molecular biology, glycoside hydrolase family 101 is a family of glycoside hydrolases. Glycoside hydrolases are a widespread group of enzymes that hydrolyse the glycosidic bond between two or more carbohydrates, or between a carbohydrate and a non-carbohydrate moiety. A classification system for glycoside hydrolases, based on sequence similarity, has led to the definition of >100 different families.Bairoch, A. "Classification of glycosyl hydrolase families and index of glycosyl hydrolase entries in SWISS-PROT". 1999.

In molecular biology, glycoside hydrolase family 57 is a family of glycoside hydrolases. Glycoside hydrolases are a widespread group of enzymes that hydrolyse the glycosidic bond between two or more carbohydrates, or between a carbohydrate and a non-carbohydrate moiety. A classification system for glycoside hydrolases, based on sequence similarity, has led to the definition of >100 different families.Bairoch, A. "Classification of glycosyl hydrolase families and index of glycosyl hydrolase entries in SWISS-PROT". 1999.

Edensew (the name also spelled Edensaw, or Edenso from the Haida chiefly name ) was born at the Haida village of Skidegate, on Haida Gwaii, located 27 miles off of the coast of British Columbia Canada. His father was of the lineage of the Raven moiety. His mother, whose lineage identity he followed in the Haida matrilineal system, was (later Mrs. John Robson) of the Eagle moiety's lineage, of which Charles eventually became chief.

Gamma-glutamyltransferase 5 is an enzyme that in humans is encoded by the GGT5 gene. Gamma-glutamyltransferase-like activity 1 (GGTLA1) is a member of a gene family with at least 4 members (GGTLA1, GGTLA2, GGTLA3 and GGTLA4). The enzyme encoded by GGTLA1 is related to, but distinct from, gamma-glutamyl transpeptidase (GGT). The GGTLA1 enzyme consists of a heavy and a light chain and is able to hydrolyze the gamma-glutamyl moiety of glutathione.

Benzamidine is a reversible competitive inhibitor of trypsin, trypsin-like enzymes and serine proteases. It is often used as a ligand in protein crystallography to prevent proteases from degrading a protein of interest; the triangular diamine group at the bottom gives it a very obvious 'stick-man' shape which shows up in difference density maps. The benzamidine moiety is also found in some pharmaceuticals, like dabigatran. Condensation with α-haloketones provides the imidazole.

Tafamidis was approved for medical use in the European Union in 2011, and in Japan in 2013. It was initially rejected in the United States in 2012, then approved in 2019. In the United States two preparations, tafamidis meglumine and tafamidis, were approved for the treatment of transthyretin mediated cardiomyopathy (ATTR-CM). The two preparations have the same active moiety, tafamidis, but they are not substitutable on a milligram to milligram basis.

CPA3 shares significant homology with the CPA subfamily of metalloprecarboxypeptidases and all the residues essential for the coordination of the Zn2+ active site, substrate peptide anchoring, and CP activity are preserved in the putative CPA3 protein. It resembles pancreatic CPA1 in cleaving C-terminal aromatic and aliphatic amino acid residues.CPA3 contains an N-terminal sequence of 16 amino acids and a pro-peptide between the NH2-terminal signal peptide sequence and COOH-terminal CP moiety.

Studies of the soluble form of human ecto-5'nucleotidase, without a GPI anchor, have shown that the C-terminal domain holds the substrate-binding pocket, and that the aromatic purine motif of the substrate is stacked between two phenylalanine residues. Furthermore, a catalytic mechanism has been proposed involving an in-line nucleophilic attack by a hydroxyl moiety that is coordinated by zinc on the substrate phosphorus, with the nucleoside acting as a leaving group.

The GDP-L-colitose biosynthesis pathway. For clarity, groups modified by the previous enzymatic step are highlighted in yellow. The biosynthesis of colitose begins with ColE, a mannose-1-phosphate guanylyltransferase that catalyzes the addition of a GMP moiety to mannose, yielding GDP-mannose. In the next step, ColB, an NADP- dependent short-chain dehydrogenase-reductase enzyme, catalyzes the oxidation at C-4 and the removal of the hydroxyl group at C-6.

Reboxetine has two chiral centers and the active ingredient is a mixture of the (R,R)-(-)- and (S,S)-(+) enantiomers. Reboxetine, like atomoxetine, contains an aryloxy propylamine moiety and has an ethoxy group in position 2’ on the phenyl ring. But the main difference from atomoxetine is the morpholine group instead of a secondary amine. The morpholine group of reboxetine forms a salt bridge and hydrogen bonds with the amino acids of NET.

The use of retentions is intended to encourage efficiency and productivity. The contractor has a financial incentive to achieve completion as early as possible (to release the first moiety payment) and to minimise defects in the works (to achieve the second payment). Retentions held against sub-contractors are also a key source of cash for main contractors, who may use them to finance new projects. However sub-contractors often complain about the system.

Triacsin C belongs to a family of fungal metabolites all having an 11-carbon alkenyl chain with a common N-hydroxytriazene moiety at the terminus. Due to the N-hydroxytriazene group, triacsin C has acidic properties and may be considered a polyunsaturated fatty acid analog. Triacsin C was discovered by Keizo Yoshida and other Japanese scientists in 1982 in a culture of the microbe Streptomyces aureofaciens. They identified it as a vasodilator.

Muramyl dipeptide is constituent of both Gram-positive and Gram-negative bacteria composed of N-acetylmuramic acid linked by its lactic acid moiety to the N-terminus of an L-alanine D-isoglutamine dipeptide. It can be recognized by the immune system as a pathogen-associated molecular pattern and activate the NALP3 inflammasome which in turn leads to cytokine activation, especially IL-1α and IL-1β.Curr Biol. 2004 Nov 9;14(21):1929-34.

Adenylyl cyclase is a membrane bound enzyme that catalyses the formation of cyclic AMP from ATP. The enzymatic activity is under the control of several hormones, and different polypeptides participate in the transduction of the signal from the receptor to the catalytic moiety. Stimulatory or inhibitory receptors (Rs and Ri) interact with G proteins (Gs and Gi) that exhibit GTPase activity and they modulate the activity of the catalytic subunit of the adenylyl cyclase.

Ubiquitin carboxyl-terminal hydrolase 1 is an enzyme that in humans is encoded by the USP1 gene. This gene encodes a member of the ubiquitin-specific processing (UBP) family of proteases that is a deubiquitinating enzyme (DUB) with His and Cys domains. This protein is located in the cytoplasm and cleaves the ubiquitin moiety from ubiquitin-fused precursors and ubiquitinylated proteins. The protein specifically deubiquitinates a protein in the Fanconi anemia (FA) DNA repair pathway.

In this process, polypeptides that have a unique stretch of 3 amino acids (asparagine - X - serine/threonine, where X represents any amino acid except proline) are modified with a complex sugar moiety on the amide group of asparagine. Other types of glycosylations include S-linked (via cysteine residues), C-linked (via tryptophan) and O-linked (via serine or threonine). By far, N-linked glycosylation is the most abundant post-translational modification found in eukaryotic cells.

The American anthropologist R. Lauriston Sharp described the Unjadi as belonging to what he called the Jathaikana type with regard to their totemic organization. By this he meant that the Unjadi lacked a moiety and section division. Their totemic clans were patrilineal whose totems were not normally tabu, tabus being applied rigorously only to personal totems from the mother's clan, which were assigned to male and female individuals with the onset of puberty.

Thiazole tautomerase (, tenI (gene)) is an enzyme with systematic name 2-(2-carboxy-4-methylthiazol-5-yl)ethyl phosphate isomerase. This enzyme catalyses the following chemical reaction : 2-[(2R,5Z)-2-carboxy-4-methylthiazol-5(2H)-ylidene]ethyl phosphate \rightleftharpoons 2-(2-carboxy-4-methylthiazol-5-yl)ethyl phosphate The enzyme catalyses the irreversible aromatization of the thiazole moiety of 2-[(2R,5Z)-2-carboxy-4-methylthiazol-5(2H)-ylidene]ethyl phosphate.

Bobby Barrdjaray Nganjmirra (c. 1915–1992) was a Kunwinjku Aboriginal artist of the Djalama clan and Yirridjdja moiety. He was born around 1915 at Malworn in West Arnhem Land, growing up primarily in a traditional lifestyle despite short periods spent at school in Gunbalanya and on Goulburn Island. He is amongst the best known of the early modern Kunwinjku bark painters and was a contemporary of artists such as Bardayal 'Lofty' Nadjamerrek and Yirawala.

Anhydrous tofogliflozin The active moiety or anhydrous form (ChemSpider ID: 28530778, CHEMBL2110731) has the chemical formula C22H26O6 and a molecular mass of 386.44 g/mol. The United States Adopted Name tofogliflozin applies to the monohydrate, which is the form used as a drug.Statement on a nonproprietary name adopted by the USAN council: Tofogliflozin. The International Nonproprietary Name tofogliflozin applies to the anhydrous compound and the drug form is referred to as tofogliflozin hydrate.

The biosynthesis of monoglycosylceramides requires a direct transfer of the carbohydrate moiety from a sugar-nucleotide, such as uridine 5-diphosphate(UDP)-galactose, or UDP-glucose to the ceramide unit. The glycosyl-transferase catalyzed reaction results in an inversion of the glycosidic bond stereochemistry, changing from α →β. Synthesis of galactosylceramide, and glucosylceramide occurs on the lumenal surface of the endoplasmic reticulum, and on the cytosolic side of the early Golgi membranes respectively.

The positive charge provides directed transport of the whole molecule including antioxidant moiety into the negatively charged mitochondrial matrix. Substances of this type, various drugs that are based on them, as well as methods of their use are patented in Russia and other countries such as USA, EU, China, Japan, etc. Sometimes the term SkQ is used in a narrow sense for the denomination of a cationic derivative of the plant antioxidant plastoquinone.

Transition state analogue example 3 Arginase is a binuclear manganese metalloprotein that catalyses the hydrolysis of L-arginine to L-ornithine and urea. It is also regarded as a drug target for the treatment of asthma. The mechanism of hydrolysis of L-arginine is carried out via nucleophilic attack on the guanidino group by water, forming a tetrahedral intermediate. Studies shown that a boronic acid moiety adopts a tetrahedral configuration and serves as an inhibitor.

Photolysis is performed resulting in photoactivation of the TIVA tag in the target cell or cells. Specifically, uncaging of the TIVA tag is accomplished using a 405-nm laser while measuring FRET excited by 514 nm. During this process, the mRNA-capturing moiety is released and subsequently anneals to the poly(A) tail of cellular mRNA. To confirm that the cell is not damaged during photolysis, the cell is imaged with the confocal microscope.

The non-nitrogenous bisphosphonates (diphosphonates) are metabolised in the cell to compounds that replace the terminal pyrophosphate moiety of ATP, forming a non-functional molecule that competes with adenosine triphosphate (ATP) in the cellular energy metabolism. The osteoclast initiates apoptosis and dies, leading to an overall decrease in the breakdown of bone. This type of bisphosphonate has overall more negative effects than the nitrogen containing group, and is prescribed far less often.

The opening of the catalytic cleft is roughly correlated with distance between R516 and phosphates of ADP. In this way, ADP activates GLUD1 by facilitating the opening of the catalytic cleft which decreases product affinity and facilitates product release. thus allowing GLUD1 to reconcile the non-catalytic abortive complexes. Inhibition by high [ADP] has been suggested previously to be due to competition between ADP and the adenosine moiety of the coenzyme at the active site1.

Phosphatidyl inositol prepared in the laboratory without regard to the isomer involved is abbreviated as PI. Phosphatidyl inositol phosphate prepared without regard to the isomer involved is abbreviated as PIP. Generic muco-inositol alone can form a dimer with the muco-inositol moiety of the sensory receptor. Although it contains no salt, or sodium ion, muco-inositol is perceived as very "salty" in this situation. It contains a natraphore within its structure.

View original at AALT. Copinger, 'County of Suffolk', II, p. 388, citing Stowe Charter 364. A grant of the watermill at Flixton and a mill at Combs was received from William de Colchester, and renewed in 1292 at Sarra's death,Tanner, Notitia, p. 528. when an inquisition was held into the priory's temporalities, and an extent taken (counting only Dunston and the moiety of Flixton churches), showing a value of £43.18s.2d.

Reactions of phosphoramidite ligand A dramatic increase in the enantioselectivity of the addition reactions was observed when a chiral amine moiety was incorporated in these phosphoramidite ligands. Excellent yields (up to 95 %) and ee values exceeding 98 % ee were achieved in the addition to cyclochexenone in the presence of the bis(1-phenylethyl)amine derived ligand. A. H. M. de Vries, A. Meetsma, B. L. Feringa, Angew. Chem.1996, 108, 2526; Angew. Chem. Int.

A preliminary analysis of the implications of the Zheng et al. data has been submitted as formal paper to a refereed journal by Steele and Lindley. The Zheng et al. data strongly imply that the RNA moiety would need to be first A-to-I RNA edited then reverse transcribed and integrated to generate the strong A>>>T strand biased mutation signatures at A:T base pairs observed in all SHM and cancer hypermutation data sets.

A daughter of de Ballon married a man named de Newmarch, their son Henry held the estate of Aust in 1166. John, his son and heir, next held Aust. One of John's daughters and co- heiress married Ralf Russell of Kingston Russell, who then held the estate. It passed in moiety through generations of the Russell and then Dennis families, through Margret Russell who married Sir Gilbert Denys (died 1422) to her grandson Walt Dennis.

Phosphorine (IUPAC name: phosphinine) is a heavier element analog of pyridine, containing a phosphorus atom instead of an aza- moiety. It is also called phosphabenzene and belongs to the phosphaalkene class. It is a colorless liquid that is mainly of interest in research. Phosphorine is an air-sensitive oil but is otherwise stable when handled using air-free techniques (however, substituted derivatives can often be handled under air without risk of decomposition).

Strongly basic quinuclidine nitrogen on the compound was considered to be responsible for this Ca2+ binding, which caused a number of systemic effects, unrelated to the blocking of the NK1 receptor. For that reason and also to simplify the structure, alkylation at this site was performed to produce analogs. The compound CP-99994 was synthesized by replacing the quinuclidine ring with a piperidine ring and benzhydryl moiety by a benzyl group (figure 2).

Pepducins are cell-penetrating peptides that act as intracellular modulators of signal transference from receptors to G proteins. Pepducins were first developed at the Tufts Medical Center laboratories of Dr. Athan Kuliopulos and Dr. Lidija Covic. Pepducins employ lipidated fragments of intracellular G protein-coupled receptor loops to modulate GPCR action in targeted cell- signaling pathways. A pepducin molecule consists of a short peptide derived from a GPCR intracellular loop tethered to a hydrophobic moiety.

Lily Hope (born in 1983), also known as Lily Lalanya Hudson, was born and raised in Juneau, Alaska by full-time artists. She mainly identifies herself as Tlingit Indian of the Raven moiety from her grandmother’s clan, the T’akdeintaan. The clan originated from Snail House in Hoonah Alaska. She was taught how to weave traditionally from her mother, Clarissa Rizal, and artist Kay Parker, both well-known and also from Juneau, Alaska.

The reagents are aryl selenenyl bromides, and they were first developed for solution phase chemistry and then modified for solid phase bead attachment via an aryloxy moiety. The solid-phase reagents were applied toward the selenenylation of various alkenes with good enantioselectivities. The products can be cleaved from the solid support using organotin hydride reducing agents. Solid-supported reagents offers advantages over solution phase chemistry due to the ease of workup and purification.

In addition to the lands revealed by the inquisitions, John Cornwall inherited small estates close to the Welsh border, including a moiety of Worthen, which had been listed among Edmund Cornwall's holdings and took in an area of the Forest of Caus. Richard II. Although he inherited several estates, John Cornwall was not left with great wealth. His mother took the proceeds of well over a third of the estates while she lived.

Tlingit tribes historically built plank houses made from cedar and today call them clanhouses; these houses were built with a foundation such that they could store their belongings under the floors. It is said that these plank houses had no adhesive, nails, or any other sort of fastening devices. Clan houses were usually square or rectangular in shape and had front facing designs and totem poles to represent which clan and moiety the makers belonged.

NAD is also consumed by sirtuins, which are NAD-dependent deacetylases, such as Sir2. These enzymes act by transferring an acetyl group from their substrate protein to the ADP-ribose moiety of NAD; this cleaves the coenzyme and releases nicotinamide and O-acetyl-ADP-ribose. The sirtuins mainly seem to be involved in regulating transcription through deacetylating histones and altering nucleosome structure. However, non-histone proteins can be deacetylated by sirtuins as well.

Certain sulfur-based steroid esters have a sulfamate or sulfonamide moiety as the ester, typically at the C3 and/or C17β positions. Like many other steroid esters, they are prodrugs. Unlike other steroid esters however, they bypass first-pass metabolism with oral administration and have high oral bioavailability and potency, abolished first-pass hepatic impact, and long elimination half-lives and durations of action. They are under development for potential clinical use.

The Archbishop of Canterbury instituted a commission with full powers "to visit the nunnery and to inquire, correct, reform and punish the excesses of delinquents". This seems to have turned matters around by the 1320s. However, in 1398 and again in 1404 the priory was exempted from collection of the second moiety of the tenth "because it is a house of poor nuns heavily encumbered". Occasionally the nunnery's superiors were termed abbesses rather than prioresses.

Mutagens identified in the Ames test need not necessarily be carcinogenic, and further tests are required for any potential carcinogen identified in the test. Drugs that contain the nitrate moiety sometimes come back positive for Ames when they are indeed safe. The nitrate compounds may generate nitric oxide, an important signal molecule that can give a false positive. Nitroglycerin is an example that gives a positive Ames yet is still used in treatment today.

The molecular formula of benoxaprofen is C16H12ClNO3 and the systematic (IUPAC) name is 2-[2-(4-chlorophenyl)-1,3-benzoxazol-5-yl]propionic acid. The molecule has a molecular mass of 301.050568 g/mol. Benoxaprofen is essentially a planar molecule. This is due to the co-planarity of the benzoxazole and phenyl rings, but the molecule also has a non-planar side chain consisting of the propanoic acid moiety which acts as a carrier group.

Branchaud and co-workers have reported that this approach, followed by an additional ring closing step, can be used to accomplish a non- repeatable 180° rotation. Feringa and co-workers used this approach in their design of a molecule that can repeatably perform 360° rotation. The full rotation of this molecular motor takes place in four stages. In stages A and C rotation of the aryl moiety is restricted, although helix inversion is possible.

Ocinaplon synthesis: Further reading:ARKIVOC 2010 (ii) 267-282 Condensation of 4-Acetylpyridine with N,N-Dimethylformamide dimethyl acetal (DMFDMA) gives the "enamide" (3). This is then condensed with (3-Amino-1H-pyrazol-4-yl)(2-pyridinyl)methanone (4) (96219-90-8). This is the same intermediate as was used in the synthesis of zaleplon in which the nitrile is replaced by a 2-acetylpyridil moiety. This affords the anxiolytic agent ocinaplon (5).

Photosensitivity is a commonly overlooked adverse effect of many of the NSAIDs. The 2-arylpropionic acids are the most likely to produce photosensitivity reactions, but other NSAIDs have also been implicated including piroxicam, diclofenac, and benzydamine. Benoxaprofen, since withdrawn due to its liver toxicity, was the most photoactive NSAID observed. The mechanism of photosensitivity, responsible for the high photoactivity of the 2-arylpropionic acids, is the ready decarboxylation of the carboxylic acid moiety.

Bag with 65 Inlaid Gambling Sticks, Tsimshian (Native American), 19th century, Brooklyn Museum The Tsimshian have a matrilineal kinship system, with a societal structure based on a clan system, properly referred to as a moiety. Descent and property are figured through the maternal line. Hereditary chiefs gained their rights through their maternal line and could be deposed by women's elders. The marriage ceremony was an extremely formal affair, several prolonged and sequential ceremonies.

Manchester Court Leet Rec. ii, 174 During the time the Chisnalls held Darcy Lever, Ralph Byrom held twelve messuages, half a water mill and fulling mill. Richard Fogg in 1612, purchased land from Ralph's son Adam Byron. When Fogg died in September 1630, the holding had increased to twenty messuages, a water mill and moiety of two fulling mills along with other land in Darcy LeverTowneley MS. C. 8, 13 (Chet Lib), fol.

Bacteria synthesize pantothenic acid from the amino acids aspartate and a precursor to the amino acid valine. Aspartate is converted to β-alanine. The amino group of valine is replaced by a keto-moiety to yield α-ketoisovalerate, which, in turn, forms α-ketopantoate following transfer of a methyl group, then D-pantoate (also known as pantoic acid) following reduction. β-alanine and pantoic acid are then condensed to form pantothenic acid (see figure).

Bloomfield F, "An essay towards a topographical history of Norfolk, volume 9", 1808: 350. In 1286, Peter de Rosceline claimed wreck at sea and frankpledge, he and his wife were living in 1316. Their son, Sir Thomas de Roseceline inherited the manor afterwards. In 1286, Sir Walter de Walcott held a moiety in Hempstead Bloomfield F, "An essay towards a topographical history of Norfolk, volume 9", 1808: 309. and was patron of Wallington in 1302.

Identification tests are conducted to ensure the identity of an analyte in a sample through comparison of the sample to a reference standard through methods such as spectrum, chromatographic behavior, and chemical reactivity. Impurity testing can either be a quantitative test or a limit test. Both tests should accurately measure the purity of the sample. Quantitative tests of either the active moiety or other components of a sample can be conducted through assay procedures.

DNA-binding domain's globular proteins contain eight cysteines and allow for a tetrahedral coordination of two zinc ions. This coordination makes the binding of ER to estrogen response elements possible. Ligand-binding domain is a globular, three-layered structure made of 11 helixes and contains a pocket for the natural or synthetic ligand. Influencing factors for binding affinity are mainly the presence of a phenol moiety, molecular size and shape, double bonds and hydrophobicity.

The first specific inhibitor developed for PDE2 was EHNA (erythro-9-(2-hydroxy-3-nonyl)adenine). It has been demonstrated to specifically act on PDE2 by inhibiting cGMP-activation of PDE2 with an IC50 value of ~1μM and an at least 50-fold selectivity over other PDEs. The core structure of EHNA resembles cAMP but differentiates in the fact that EHNA has a bulky hydrophobic carbon side chain replacing the phospho-ribose moiety in cAMP.

These researchers posit that the p-hydroxybenzoic acid moiety (6) is absorbed directly from the lignin on which the fungus feeds, not produced by the fungus itself (Figure 2). (6) 4-hydroxybenzoic acid, also known as p-hydroxybenzoic acid Despite recent work, however, experts still acknowledge the nebulous origin of the hydrazine functionality. Two theoretical mechanisms are postulated: oxidative coupling of two amines via a phenolic radical mechanism or fixation of nitrogen via nitrogenase.

Many Indigenous communities also have a very complex kinship structure and in some places strict rules about marriage. In traditional societies, men are required to marry women of a specific moiety. The system is still alive in many Central Australian communities. To enable men and women to find suitable partners, many groups would come together for annual gatherings (commonly known as corroborees) at which goods were traded, news exchanged, and marriages arranged amid appropriate ceremonies.

The first step involves a transfer of a coumaroyl moiety from a 4-coumaroyl-CoA starter molecule to Cys164. Next, a series of condensation reactions of three acetate units from malonyl-CoA occurs, each proceeding through an acetyl-CoA carbanion derived from malonyl-CoA decarboxylation. This extends the polyketide intermediate. After the generation of a thioester-linked tetraketide, a regiospecific C1,C6 Claisen condensation occurs, forming a new ring system to generate naringenin chalcone.

To create catenanes, the cyclobis(paraquat-p- phenylene) can be used as a template to "thread" a crown ether with a π-donor component. Subsequently, its still open ends are linked with each other to obtain two closed rings. A bistable catenane (a ring with two π-donor components) is already a simple example of a molecular switch. In the present example, a cyclic ether has been selected with a TTF and a DNP moiety.

Wululu was born in 1936 and he died on 5 October 2005. He is an artist of the Gupapuyngu language group and part of the Yirritja moiety and he is from Arnhem Land in Australia. He grew up at the Milingimbi Methodist Mission and he first worked as a laborer and a builder. He started painting professionally in the late 1970s and his works are said to be in the traditional Arnhem Land tradition.

Glycoside hydrolase enzymes hydrolyse the glycosidic bond between two or more carbohydrates, or between a carbohydrate and a non- carbohydrate moiety. This gene encodes a member of glycosyl hydrolases family 31. This enzyme hydrolyses terminal, non-reducing 1,4-linked alpha-D-glucose residues and releases alpha-D-glucose. This is a key enzyme in glycogen metabolism and its gene localizes to a chromosomal region (15q15) that is associated with susceptibility to diabetes.

In molecular biology, glycoside hydrolase family 36 is a family of glycoside hydrolases. Glycoside hydrolases are a widespread group of enzymes that hydrolyse the glycosidic bond between two or more carbohydrates, or between a carbohydrate and a non-carbohydrate moiety. A classification system for glycoside hydrolases, based on sequence similarity, has led to the definition of >100 different families.Bairoch, A. "Classification of glycosyl hydrolase families and index of glycosyl hydrolase entries in SWISS-PROT". 1999.

Guanosine-5'-triphosphate (GTP) is a purine nucleoside triphosphate. It is one of the building blocks needed for the synthesis of RNA during the transcription process. Its structure is similar to that of the guanosine nucleoside, the only difference being that nucleotides like GTP have phosphates on their ribose sugar. GTP has the guanine nucleobase attached to the 1' carbon of the ribose and it has the triphosphate moiety attached to ribose’s 5' carbon.

The cyanogenic glycosides in some white clover (Trifolium repens) varieties may influence the Se requirement, presumably because of cyanide from the aglycone released by glucosidase activity in the rumen and inactivation of glutathione peroxidases by the effect of absorbed cyanide on the glutathione moiety. In areas where selenium deficiency in livestock is a concern, selenium (as selenite) may be supplemented in feed. In some countries, e.g. the US and Canada, such supplementation is regulated.

Mawalan created an entire series of paintings detailing the journey on the Djang'kawu sisters into country. As well as being known for his bark paintings, Marika had a high level of skill in carving and sculpture. His sculptures are cleanly painted with clan designs and finished with feathers, human hair, or other such natural attachments. His style is characteristic of the Dhuwa moiety, featuring many dots, diagonal lines, and geometric/diamond shapes.

Warenne offered King John 500 marks for licence to marry Melisent, the widow of Richard de Montfichet and mother of Richard de Montfichet, lord of the manor of Stansted in Essex.Turner English Judiciary p. 113 Warenne's only surviving child and sole-heiress was his daughter, Beatrice, whom he married to Doun Bardolf, the holder of a one-half moiety of the feudal barony of Shelford in Nottinghamshire. Beatrice married secondly Ralph,Saunders English Baronies pp.

Another William Alis possessed the estate until he died in 1304 without male issue, leaving the property to his two daughters with his widow retaining a life interest. The daughters were Isabella, who was married to Robert le Helyon, and Margaret, who had married William le Rolleston. They each inherited a portion of the manor, the history of which diverges at this stage. Two years after Margaret inherited her moiety, it passed to Richard Woodlock.

Rivaroxaban binding to FXa is mediated through two hydrogen bonds to the amino acid Gly-219. These two hydrogen bonds serve an important role directing the drug into the S1 and S4 subsites of FXa. The first hydrogen bond is a strong interaction which comes from the carbonyl oxygen of the oxazolidinone core of rivaroxaban. The second hydrogen bond is a weaker interaction and comes from the amino group of the clorothiophene carboxamide moiety.

Antineoplastic agents related to EMP, although none of them were marketed, include alestramustine, atrimustine, cytestrol acetate, estradiol mustard, ICI-85966, and phenestrol. Due to its hydrophilic phosphate ester moiety, EMP is a readily water-soluble compound. This is in contrast to most other estradiol esters, which are fatty acid esters and lipophilic compounds that are not particularly soluble in water. Unlike EMP, estramustine is highly lipophilic, practically insoluble in water, and non-ionizable.

As with other members of the penicillin family, the chemical structure of oxacillin features a 6-aminopenicillanic acid nucleus with a substituent attached to the amino group. The 6-aminopenicillanic acid nucleus consists of a thiazolidine ring attached to a β-lactam ring, which is the active moiety responsible for the antibacterial activity of the penicillin family. The substituent present on oxacillin is thought to impart resistance to degradation via bacterial β-lactamases.

Ceftriaxone is commercially available as a white to yellowish-orange crystalline powder for reconstitution. Reconstituted ceftriaxone injection solutions are light yellow- to amber-colored depending on how long the solution had been reconstituted, the concentration of ceftriaxone in the solution, and the diluent used. To reduce pain with intramuscular injections, ceftriaxone may be reconstituted with lidocaine. The syn-configuration of the methoxyoxime moiety confers resistance to beta-lactamase enzymes produced by many Gram-negative bacteria.

The CDO mechanism is still not well understood, despite active research to elucidate details of the reaction. Overall, the reaction involves addition of O2 to cysteine, which occurs spontaneously without enzyme catalysis. Studies have shown that the cysteinyltyrosine bridge lowers the oxidation potential of tyrosine (commonly an electron donor, as in photosystem II) by ~0.5 V relative to phenol and increases its acidity. The thioether moiety likely plays a structural, redox, or, acid/base role.

Hydroxyzine can be administered orally or via intramuscular injection. When given orally, hydroxyzine is rapidly absorbed from the gastrointestinal tract. The effect of hydroxyzine is notable in 30 minutes. Hydroxyzine is rapidly absorbed and distributed with oral and intramuscular administration, and is metabolized in the liver; the main metabolite (45%), cetirizine, is formed through oxidation of the alcohol moiety to a carboxylic acid by alcohol dehydrogenase, and overall effects are observed within one hour of administration.

Testosterone esters are substituted at the C17β position with a lipophilic fatty acid ester moiety of varying chain length. Major testosterone esters include testosterone cypionate, testosterone enanthate, testosterone propionate, and testosterone undecanoate. A C17β ether prodrug of testosterone, cloxotestosterone acetate, has also been marketed, although it is little known and is used very rarely or no longer. Another C17β ether prodrug of testosterone, silandrone, also exists but was never marketed, and is notable in that it is orally active.

Convolutamine A is the 2,4,6-tribromo-1,7-dimethoxy derivative of DMT, a hallucinogen that occurs naturally in many plants and animals. Convolutamine A is chemically related to 5-bromo-DMT which also occurs in many marine invertebrates. Until the discovery of convolutindole A, the 1-methoxyindole moiety was unknown in the marine world. 1-Methoxyindoles, such as lespedamine, were previously only known to occur in legumes and the Brassicaceae, the plant family that cabbage and mustard belong to.

Members of the deceased's family were allowed to stop mourning. If the deceased was an important member of the community, like a chief or a shaman for example, at the memorial potlatch his successor would be chosen. Clan members from the opposite moiety took part in the ritual by receiving gifts and hearing and performing songs and stories. The function of the memorial potlatch was to remove the fear from death and the uncertainty of the afterlife.

Metabolism and Hofmann elimination vecuronium binds to the nicotinic receptor. Its D-ring binds to the receptor at two points and the lipophillic side of the molecule repels cations from flowing through the ion-channel Deacetylating vecuronium at position 3 results in a very active metabolite. In the case of rapacuronium the 3-deacylated metabolite is even more potent than rapacuronium. As long as the D-ring acetylcholine moiety is unchanged they retain their muscle relaxing effect.

The primary amine group in the aminoallyl moiety is aliphatic and thus more reactive compared to the amine groups that are directly attached to the rings (aromatic) of the bases. Common names of aminoallyl nucleosides are initially abbreviated with aa- or AA- to indicate aminoallyl. The 5-carbon sugar is indicated with or without the lowercase "d" indicating deoxyribose if included or ribose if not. Finally the nitrogenous base and number of phosphates are indicated (i.e.

The Totnes sister of unknown name married Henry de Tracy (died pre-1165), to whom approximately half of the constituent manors of the barony, including Bremridge, were allocated as his wife's inheritance. Henry left a son and heir Oliver I de Tracy (died c. 1184), who in 1165 was charged scutage on 25 knight's fees for his moiety. In the Cartae Baronum of 1166 he declared 23 1/3 and in 1168 30 1/2 knights' fees.

In this reaction, an aryl halide (usually iodide or bromide) exchanges with organolithium to form a lithiated arene species. If the arene bears a side chain with an electrophillic moiety, the carbanion attached to the lithium will perform intramolecular nucleophilic attack and cyclize. This reaction is a useful strategy for heterocycle formation. In the example below, Parham cyclization was used to in the cyclization of an isocyanate to form isoindolinone, which was then converted to a nitrone.

The beta sheet face is basic, consistent with a role in RNA binding. Proximal to the basic beta sheet face is another moiety that could contribute to nucleic acid recognition. Connecting strand beta1 and helix alpha2 is a loop with a six amino acid motif, GxxG flanked by large aliphatic residues, within which one 'x' is typically a basic residue. Escherichia coli YhbY is associated with pre-50S ribosomal subunits, which implies a function in ribosome assembly.

Nudix hydrolases are a superfamily of hydrolytic enzymes capable of cleaving nucleoside diphosphates linked to x (any moiety), hence their name. The reaction yields nucleoside monophosphate (NMP) plus X-P. Substrates hydrolysed by nudix enzymes comprise a wide range of organic pyrophosphates, including nucleoside di- and triphosphates, dinucleoside and diphosphoinositol polyphosphates, nucleotide sugars and RNA caps, with varying degrees of substrate specificity. Enzymes of the Nudix superfamily are found in all types of organisms, including eukaryotes, bacteria and archaea.

The membrane lipids of Thaumarchaeota are composed of glycerol dialkyl glycerol tetraethers (GDGTs) which contain 0-3 cyclopentane moieties. Thaumarchaeota also synthesise crenarchaeol which contains four cyclopentane moieties and a single cyclohexane moiety and a regio-isomer. The cyclohexane and cyclopentane rings, formed by internal cyclisation of one of the biphytane chains,Schouten, S., Hopmans, E. C., and Sinninghe Damsté, J. S., 2013, The organic geochemistry of glycerol dialkyl glycerol tetraether lipids: A review: Organic Geochemistry, v. 54, no.

Trehalulose is a disaccharide made up of a molecule of fructose bound to a molecule of glucose. Like isomaltulose, it is a structural isomer of sucrose that is present in small quantities in honey. It makes up 50% of sugars in the honeydew of silverleaf whiteflies and is synthesised from sucrose by some bacteria, such as Protaminombacter rubrum. Because the anomeric carbon of the fructose moiety is not involved in the glycosidic bond, it is a reducing sugar.

Chemical structure of cannbigerolic acid (CBGA), the substrate for THCA synthase. THCA synthase, a flavoprotein, uses a flavin adenine dinucleotide (FAD) cofactor to catalyze the oxidative cyclization of the monoterpene moiety of cannabigerolic acid (CBGA). Similar cyclization reactions occur in monoterpene biosynthesis from geranyl pyrophosphate, but are not oxidative. THCA synthase exhibits no catalytic activity against cannabigerol, which lacks a carboxyl group compared to CBGA, suggesting that the carboxyl group of CBGA is necessary for the reaction to occur.

Kethoxal causes the modification of guanine, specifically altering the N1 and the exocyclic amino group (N2) simultaneously by covalent interaction. Glyoxal, methylglyoxal, and phenylglyoxal, which all carry the key 1,2-dicarbonyl moiety, all react with free guanines similar to kethoxal, and can be used to probe unpaired guanine bases in structured RNA. Due to their chemical properties, these reagents can permeate readily into cells and can therefore be used to assay RNAs in their native cellular environments.

The polymerization reaction with the amine group eliminates hydrogen chloride. The acid chloride route can be used as a laboratory synthesis to avoid heating and obtain an almost instantaneous reaction. The aromatic moiety itself does not participate in elimination reaction, but it does increase the rigidity and strength of the resulting material which leads to Kevlar's renowned strength. In the diagram below, Aramid is made from two different monomers which continuously alternate to form the polymer.

Sulfonamides are used to treat allergies and cough, as well as antifungal and antimalarial functions. The moiety is also present in other medications that are not antimicrobials, including thiazide diuretics (including hydrochlorothiazide, metolazone, and indapamide, among others), loop diuretics (including furosemide, bumetanide, and torsemide), acetazolamide, sulfonylureas (including glipizide, glyburide, among others), and some COX-2 inhibitors (e.g., celecoxib). Sulfasalazine, in addition to its use as an antibiotic, is also used in the treatment of inflammatory bowel disease.

Florence (“Suzie”) Scundoo (Kaatxwaaxsnéi) was born in Haines, Alaska in 1882. She was the daughter of a high-ranking shaman of the Mountain house clan of Chilkat, and she came from the Raven moiety. Her Tlingit given name, Kaatxwaaxsnéi, referred to a ceremony held on a special occasion, when clan elders would mix powdered abalone and clam shells with tobacco to be smoked. From her mother, Florence learned the arts of Chilkat beading and blanket weaving.

The silyl moiety forces electrophilic attack on the face opposite the silyl group for steric and electronic reasons, although the effects are not large. This model predicts that when the double bond is 1,2-disubstituted, the Z isomer should exhibit greater selectivity than the E isomer, and this has been observedVedejs, E.; McClure, C. K. J. Am. Chem. Soc. 1986, 108, 1094. (5)File:SiAddStereo.png Vinylsilane additions proceed with retention of double bond configuration, and follow a similar principle.

According to the Indigenous Australian mythology of the Dreamtime, the Bunurong territory was created by the ancestor spirit Lohan. Patrilineally, all Bunurong tribe members are considered direct descendants of Lohan. The creator of the Kulin nation-proper was the deity eaglehawk spirit Bunjil, and the protector of its waterways and keeper of the wind was the trickster crow spirit Waa. Bunjil and Waa are the two moiety totems that govern the kinship system of the Kulin nation tribes.

The heparin pentasaccharide-bound form of antithrombin is, thus, a more effective inhibitor of thrombin and factor Xa. Furthermore, both of these coagulation proteases also contain binding sites (called exosites) for heparin. Heparin, therefore, also acts as a template for binding of both protease and serpin, further dramatically accelerating the interaction between the two parties. After the initial interaction, the final serpin complex is formed and the heparin moiety is released. This interaction is physiologically important.

The next step is the addition of the acyloxy moiety by a P450 acetyltransferase; which is a well known reaction for the synthesis of the diterpene, taxol. In the third step, the lactone ring is formed by a cytochrome P450 enzyme using NADP+. With the butyloxy group on the C(8), the formation will only generate the 6,12-lactone ring. The fourth step is an epoxidation that initiates the last step of the base guaianolide formation.

The terminally bound maltose moiety maintains affinity for both analytes, thus the modified TRP, pAPM, met critical conditions of external temperature requirements and affinity for both target analytes. The solubility properties changed from 4 °C (soluble) to 8 °C (insoluble). Several reagents were tested for the recovery of Con A by desorption which had higher binding affinities to Con A than maltose. These reagents were α-D-glucopyranoside, D-mannose, methyl α-D-mannopyranoside, and glucose.

Nicotinamide adenine dinucleotide phosphate, abbreviated NADP or, in older notation, TPN (triphosphopyridine nucleotide), is a cofactor used in anabolic reactions, such as the Calvin cycle and lipid and nucleic acid syntheses, which require NADPH as a reducing agent. It is used by all forms of cellular life. NADPH is the reduced form of NADP. NADP differs from NAD by the presence of an additional phosphate group on the 2' position of the ribose ring that carries the adenine moiety.

Troglitazone, like the other thiazolidinediones (pioglitazone and rosiglitazone), works by activating peroxisome proliferator-activated receptors (PPARs). Troglitazone is a ligand to both PPARα and – more strongly – PPARγ. Troglitazone also contains an α-tocopheroyl moiety, potentially giving it vitamin E-like activity in addition to its PPAR activation. It has been shown to reduce inflammation: troglitazone use was associated with a decrease of nuclear factor kappa-B (NF-κB) and a concomitant increase in its inhibitor (IκB).

Schematic illustration of a generic phosphasilene with a three-coordinate silicon atom and a two-coordinate phosphorus atom. Phosphasilenes or silylidenephosphanes are a class of compounds with silicon-phosphorus double bonds. Since the electronegativity of phosphorus (2.1) is higher than that of silicon (1.9), the "Si=P" moiety of phosphasilene is polarized. The degree of polarization can be tuned by altering the coordination numbers of the Si and P centers, or by modifying the electronic properties of the substituents.

Structural formula of indole Indole alkaloids are a class of alkaloids containing a structural moiety of indole; many indole alkaloids also include isoprene groups and are thus called terpene indole or secologanin tryptamine alkaloids. Containing more than 4100 known different compounds, it is one of the largest classes of alkaloids. Many of them possess significant physiological activity and some of them are used in medicine. The amino acid tryptophan is the biochemical precursor of indole alkaloids.

In organic chemistry, a directing group (DG) is a substituent on a molecule or ion that facilitates reactions by interacting with a reagent. The term is usually applied to C-H activation of hydrocarbons, where it is defined as a "coordinating moiety (an “internal ligand”), which directs a metal catalyst into the proximity of a certain C–H bond." In a well known example, the ketone group in acetophenone is the DG in the Murai reaction. Murai reaction.

Lady Essex Howard married Edward Griffin, 1st Baron Griffin, and had descendants. Her granddaughter the Hon. Ann Griffin was the only surviving daughter of the 2nd Baron Griffin, and her son John Griffin Whitwell, later Field Marshal John Griffin Griffin (he changed his surname in 1749), inherited one-half or a moiety of the barony when his maternal uncle the 3rd Baron Griffin died without legitimate issue. In 1784, the barony was called out of abeyance in his favour.

Mycophenolate can be derived from the fungi Penicillium stoloniferum, P. brevicompactum and P. echinulatum. Mycophenolate mofetil is metabolised in the liver to the active moiety mycophenolic acid. It reversibly inhibits inosine monophosphate dehydrogenase, the enzyme that controls the rate of synthesis of guanine monophosphate in the de novo pathway of purine synthesis used in the proliferation of B and T lymphocytes. Other cells recover purines via a separate salvage pathway and are thus able to escape the effect.

On 11 June 1284 John Devereux was granted warranty on 1 messuage and a moiety of 1 virgate of land in Callow Hill (in Munsley). Ralph le Child of Upleadon acknowledged the tenements to be the right of John; and Devereux agreed to render to him 1 penny yearly at the feast of St Michael and perform for the chief lords all other services. For this John Devereux gave him 11 marks of silver., Medieval Genealogy Website.

The group that gave the best effects on basicity was 3-oxo-1,2,4-triazol-5-yl moiety and it gave compounds such as L-741671 and L-742694. A morpholine nucleus that was introduced in L-742694 was found to enhance NK1 binding affinity. This nucleus was preserved in further modifications. In order to prevent possible metabolic deactivation, several refinements such as methylation on the C alfa of the benzyl ring and fluorination on the phenyl ring were introduced.

The onset time to gastrointestinal symptoms is unknown, but probably exceeds 12 hours. An early study suggested that L. monocytogenes is unique among Gram-positive bacteria in that it might possess lipopolysaccharide, which serves as an endotoxin. Later, it was found to not be a true endotoxin. Listeria cell walls consistently contain lipoteichoic acids, in which a glycolipid moiety, such as a galactosyl-glucosyl- diglyceride, is covalently linked to the terminal phosphomonoester of the teichoic acid.

Additionally, pH levels control specificity of substrate binding by malate dehydrogenase due to proton transfer in the catalytic mechanism. A histidine moiety with a pK value of 7.5 has been suggested to play a role in the pH- dependency of the enzyme. Studies have indicated that the binding of the enol form oxaloacetate with the malate dehydrogenase:NADH complex forms much more rapidly at higher pH values. Additionally, L-malate binding to malate dehydrogenase is promoted at alkaline conditions.

Tetrazepam is an unusual benzodiazepine in its molecular structure as it has cyclohexenyl group which has substituted the typical 5-phenyl moiety seen in other benzodiazepines. Tetrazepam, is rapidly absorbed after oral administration, within 45 mins and reaches peak plasma levels in less than 2 hours. It is classed as an intermediate acting benzodiazepine with an elimination half-life of approximately 15 hours. It is primarily metabolised to the inactive metabolites 3-hydroxy-tetrazepam and norhydroxytetrazepam.

Protein prenylation involves the transfer of either a farnesyl or a geranylgeranyl moiety to C-terminal cysteine(s) of the target protein. There are three enzymes that carry out prenylation in the cell, farnesyl transferase, Caax protease and geranylgeranyl transferase I. Farnesylation is a type of prenylation, a post-translational modification of proteins by which an isoprenyl group is added to a cysteine residue. It is an important process to mediate protein–protein interactions and protein–membrane interactions.

This system had been in place for many years and was referred to as Moiety. Jayne made an unannounced visit to the Phelps Dodge office and seized their books. Later he informed them that they were liable to pay a forfeit of $1,750,000. Without access to his ledgers, the senior partner of the firm, William E. Dodge, was unable to verify the underpayment of duty and was forced to reach a settlement with Jayne of $271,000.

22 The scutage roll states: Johannes Russel mittat unum militem pro terra qui fuit Jacobi de Novomercato (John Russell sent one knight in respect of the land which was of James de Newmarch (Latinised to "New-Market")). Below this entry is the record of a summons to John de Bottrel, who held the other moiety of the barony of North Cadbury: Johannes de Botereauls veniat pro eadem terra (John de Bottrel came in respect of the same land).

Visible light that hits the chromophore can thus be absorbed by exciting an electron from its ground state into an excited state. In biological molecules that serve to capture or detect light energy, the chromophore is the moiety that causes a conformational change of the molecule when hit by light. Healthy plants are perceived as green because chlorophyll absorbs mainly the blue and red wavelength and reflects the green. β-carotene molecule are highlighted in red.

Demecolcine (INN; also known as colcemid) is a drug used in chemotherapy. It is closely related to the natural alkaloid colchicine with the replacement of the acetyl group on the amino moiety with methyl, but it is less toxic. It depolymerises microtubules and limits microtubule formation (inactivates spindle fibre formation), thus arresting cells in metaphase and allowing cell harvest and karyotyping to be performed. During cell division, demecolcine inhibits mitosis at metaphase by inhibiting spindle formation.

The triphosphate binding site overlaps with that of UTP, but the nucleoside moiety of CTP binds in an alternative pocket opposite the binding site for UTP. CTP synthase levels have been shown to be dependent on levels of the transcription factor Myc. In turn, CTP synthase activity is required for Myc related phenotypes. The glutamine analog DON has also been seen to act as an irreversible inhibitor, and has been used as an anti-cancer agent.

262 which wounds however apparently allowed him to live on to a great age. Regarding any progeny, Nicholas (1832) stated: "Nothing can with certainty be said of his parents, nor is it positively known whether he left descendants". The Westcountry historian Polwhele (d.1838) states however that the last male of the de Sully family left an only daughter who married Vowel, a Somersetshire knight, from whom the Smith family inherited a moiety of the manor of Iddesleigh.

The A1 domain activates and loads threonine, an amino acid, onto T1, followed by a C1 promoted condensation of 3-aminosalicylate and threonine. The A2 domain activates and loads pyruvate onto T2. Pyruvate is reduced by the KR domain and condensed with threonine by C2 6\. The Ketosynthase domain of PKS catalyses the decarboxylative condensation between the aminoacyl thioester attached to AntC T2 domain and the 2-carboxy-acyl moiety attached to AntD Acetyl Carrier Protein domain. 7\.

In 1567 Oxford was admitted to Gray's Inn, one of the Inns of Court which Justice Shallow reminisces about in Henry IV, Part 2. Sobran observes that the Sonnets "abound not only in legal terms – more than 200 – but also in elaborate legal conceits." These terms include: allege, auditor, defects, exchequer, forfeit, heirs, impeach, lease, moiety, recompense, render, sureties, and usage. Shakespeare also uses the legal term "quietus" (final settlement) in Sonnet 134, the last Fair Youth sonnet.

Using a different lead, optimization from S-8308, eprosartan was developed by SmithKline Beecham in 1992. Eprosartan does not have a biphenyl-methyl structure but in order to mimic the C-terminal end of Ang II the 5-acetic acid group was replaced with an a-thienylacrylic acid and a 4-carboxy-moiety. Eprosartan is a selective, potent and competitive AT1 antagonist and its binding to AT1 receptors is rapid, reversible, saturable and of high affinity.

Pratosartan structure. Several new nonpeptide ARBs are undergoing clinical trials or are at pre-clinical stages of development. Among these are embusartan (BAY 10-6734 or BAY 10-6734), KRH-594, fonsartan (HR 720) and pratosartan (KT3-671). Pratosartan, for example, has a novel structure: a seven-membered ring that bears an oxo moiety (C=O) fused to the imidazole ring (figure 4), and its affinity for the AT1 receptor is about 7 times higher than losartan's.

There are two moieties: the Mandayung (with myths that tend to associate it with continuity and dispute resolution) and the Mandaridja, whose myths suggest experimentation and change. They mirror in some respects the dua/yiridja moiety structures of the Yolngu of northeast Arnhem Land. For this reason Mandaridja people absorb into their totemic systems things that are of foreigtn provenance, such as ships, planes and tractors. There are two mytho- ritual complexes divided among these respective moieties.

Born in 1961, Owen Yalandja belongs to the Kuninjku people within Maningrida (Northern Territory of Central Arnhem Land). He is now a senior member of the Dangkorlo clan, which means that he has the responsibility to be custodians of a yawkyawk site (Yirridjdja moiety) in the Mirrayar billabong. Yawkyawk are female water spirits, similar to the Western mermaids. However, they are more than a mystical creature; to the Kuninjku people, yawkyawks are manifestations of their young female ancestors.

The coenzyme NAD and its derivatives are involved in hundreds of metabolic redox reactions and are utilized in protein ADP-ribosylation, histone deacetylation, and in some Ca2+ signaling pathways. NMNAT (EC 2.7.7.1) is a central enzyme in NAD biosynthesis, catalyzing the condensation of nicotinamide mononucleotide (NMN) or nicotinic acid mononucleotide (NaMN) with the AMP moiety of ATP to form NAD or NaAD. NMNAT1 is the most widely expressed of three orthologous genes with nicotinamide-nucleotide adenylyltransferase (NMNAT) activity.

It was observed that substituting Asn9 with Glu produced a greater effect than changing Asn9 to Asp. Asn contains a polar uncharged side chain, while both Asp and Glu contain a polar charged side chain. The increased effect of Glu is caused by the extra carbon in its side chain that brings it closer to adenyl ribose moiety. This allows for stronger hydrogen bonding between the 2’- and 3’- ribose hydroxyl groups and the side chain carboxyl group.

John I de Beauchamp (died 1283), son and heir, who married Cecily de Vivonne/de Forz (died 1320), one of the four daughters and co-heiresses of William de Vivonne/de Forz (died 1259), who held a one-half moiety of the feudal barony of Curry Mallet in Somerset.Sanders, pp.38-9 Cecily thus inherited a one-eighth share of the barony of Curry Malet. He served as Governor of Carmarthen Castle and of Cardigan Castle, both in Wales.

Like montelukast, zafirlukast antagonizes bronchoconstrictive by selectively antagonising the CysLT1 receptor and affects all of the leukotrienes (LTC4, LTD4, and LTE4). The qualitative structural requirements and pharmacophore for CysLT1 antagonists were designed from the structural similarity of the agonist LTD4. But that has its limitations as agonist and antagonist do not necessarily bind in the same manner nor to the same site. So the importance of certain moiety may be overestimated and some moieties may be overlooked.

Naloxegol is a polyethylene glycol-modified derivative of α-naloxol. Naloxegol has a similar form as naloxone as a heteropentacyclic compound both of which have an allyl group attached to the amine of the piperidine ring. However, naloxegol has a monomethoxy-terminated n=7 oligomer of PEG connected to the 6-alpha- hydroxyl group of ɑ-naloxol via an ether linkage. The PEG moiety increases the molecular weight and therefore restricts the uptake of naloxegol into the CNS.

In 2002 the Queen terminated the abeyance of the Barony of Herbert in his favour.By the laws of succession to ancient English baronies, daughters and co-heiresses inherit equal shares. Lady Blanche's daughters or their heirs inherited equal shares in the barony; however, David Seyfried was the elder son and thus sole heir of his mother, the younger daughter. The elder daughter had two surviving daughters who became co-heiresses to their mother's moiety or one-half.

For details, see discussions on the Usenet group alt.talk.royalty. He is also a co-heir, with one moiety, to the Barony of Botetourt. Lord Herbert represented the Lancastrian peers who fought at the Battle of Bosworth during the re-interment of King Richard III on 26 March 2015 at Leicester Cathedral. The descendants of the York and Lancastrian peers that were present at Bosworth accompanied the funeral cortège and escorted the body of King Richard into the Cathedral.

In neutral media (pH 7), only the nitrogen atom of the diphenylamine moiety carries a positive charge and the blue dye molecule is an anion with an overall charge of −1. The pKa for the loss of the two protons are 1.15 and 1.82 respectively. The final proton is lost under alkaline conditions and the dye becomes pink in colour (pKa 12.4). The dye interacts electrostatically but noncovalently with the amino and carboxyl groups of proteins.

Chlorotonil A is a polyketide natural product produced by the myxobacterium Sorangium cellulosum So ce1525, and displays notable antimalarial, antibacterial, and antifungal activity. The activity of chlorotonil A has been attributed to the gem-dichloro-1,3-dione moiety, which is a unique functionality in polyketides. In addition to its unique halogenation, the structure of chlorotonil A has also garnered interest due to its similarity to anthracimycin, a polyketide natural product with antibiotic activity against Gram-positive bacteria.

McFeely- Woodward (1974), Responses of the Presidents to Charges of Misconduct, pp. 133-134 Grant placed leading reformer George William Curtis as head of the civil service commission set up to establish regulations, in order to ensure the best person qualified would hold office. In addition to signing the civil service reform, Grant limited and finally abolished the moiety system in which private citizens contracted as Treasury revenue agents and received a percentage of delinquent taxes assessed and collected.

This heme moiety is in relation to the β-face that the natural hormone androstenedione coordinates with. The structure of androstenedione contains two ketones that form hydrogen bonds with the amino acids, Asp309 and Met374. Also, in the active binding site the 17-ketone group interacts with the amino acid, Arg115. Additionally, at the binding site, androstenedione make Van der Waals forces with several amino acids, more specifically Arg115, Ile133, Phe134, Phe221, Trp224, Ala306, Thr310, Val370, Val373, Met374and Leu477 .

Leinamycin is an 18-membered macrolactam produced by several species of Streptomyces atroolivaceus. This macrolactam has also been shown to exhibit antitumor properties as well as antimicrobial properties against gram-positive and gram-negative bacteria. The presence of a spiro-fused 1,3-dioxo-1,2-dithiolane moiety was a unique structural property at the time of this compound's discovery and it plays an important role in leinamycin's antitumor and antibacterial properties due to its ability to inhibit DNA synthesis.

The biotin-binding properties of avidin were exploited during the development of idrabiotaparinux, a long-acting low molecular weight heparin used in the treatment of venous thrombosis. Due to the long-acting nature of idraparinux, concerns were made about the clinical management of bleeding complications. By adding a biotin moiety to the idraparinux molecule, idrabiotaparinux was formed; its anticoagulant activity in the setting of a bleeding event can be reversed through an intravenous infusion of avidin.

It is a member of the FASII cycle along with FabI and FabA, which synthesise the precursors utilised by FabG. Another gene necessary for synthesis of di-rhamnolipids, rhlC, has also been identified. RhlC catalyses the addition of the second rhamnose moiety to mono-rhamnolipids forming di-rhamnolipids, hence is often labelled rhamnosyltransferase 2. Like rhlA and rhlB, rhlC is thought to be an ancestral gene controlled by the same quorum sensing system as rhlA and rhlB.

120px Ceftobiprole is the active moiety of the prodrug ceftobiprole medocaril and is available for intravenous treatment only. The recommended dose is 500 mg as 2-hour infusion every 8 hours. It is mainly excreted renally. Dose adjustment is required for patients with moderate or severe renal impairment and for patients with end-stage renal disease, but no dose adjustment is needed by gender, ethnicity or age, in severely obese patients or in patients with hepatic impairment.

Glycoside hydrolase family 1 is a family of glycoside hydrolases. Glycoside hydrolases are a widespread group of enzymes that hydrolyse the glycosidic bond between two or more carbohydrates, or between a carbohydrate and a non- carbohydrate moiety. A classification system for glycoside hydrolases, based on sequence similarity, has led to the definition of >100 different families. This classification is available on the CAZy web site, and also discussed at CAZypedia, an online encyclopedia of carbohydrate active enzymes.

Mithinarri first learned to paint as a young man, receiving mentorship from a group of Dhuwa moiety artists that included notable artists like Larrtjannga Ganambarr and Wandjuk Marika. They were taught by Wandjuk’s father, Mawalan Marika, a master bark painter, at Beach Camp in Yirrkala in Arnhem Land. Mithinarri was often characterized as an eccentric man. He usually camped slightly apart from the other members of his community though he would be often surrounded by his children.

Potential application as long-lasting dyes is based on the enhanced stability of the inner portion of the dumbbell-shaped molecule. Studies with cyclodextrin- protected rotaxane azo dyes established this characteristic. More reactive squaraine dyes have also been shown to have enhanced stability by preventing nucleophilic attack of the inner squaraine moiety. The enhanced stability of rotaxane dyes is attributed to the insulating effect of the macrocycle, which is able to block interactions with other molecules.

These fused proteins are called the bait and prey, respectively. In addition to being fused to an integral membrane protein, the Cub moiety is also fused to a transcription factor (TF) that can be cleaved off by ubiquitin specific proteases. Upon bait–prey interaction, Nub and Cub-moieties assemble, reconstituting the split-ubiquitin. The reconstituted split-ubiquitin molecule is recognized by ubiquitin specific proteases, which cleave off the transcription factor, allowing it to induce the transcription of reporter genes.

Garma is held at Gulkula, a significant Gumatj ceremonial site in northeast Arnhem Land, in a stringy-bark forest atop an escarpment overlooking the Gulf of Carpentaria. The trees on the escarpment at Gulkula are mainly of one species of stringybark known as Eucalyptus tetradonta. In Yolngu culture the grey stringy-barks have many names, and one Dhuwa moiety name is "Gadayka". In August, Gadayka is in flower and small native bees turn nectar into honey.

Pluramycin A is an antibiotic/anticancer compound that inhibits nucleic acid biosynthesis. The pluramycin family of natural products are an important group of complex C-aryl glycoside antibiotics that possess the tetracyclic 4H-anthra[1,2-b]pyran-4,7,12-trione moiety A–D as an aromatic core. The D-ring is adorned with two deoxyaminosugars that are appended by C-aryl glycosidic linkages. The E-ring sugar is angolosamine, a carbohydrate that is also found in the antibiotic angolamycin.

The Nukunu were the southeasternmost tribe which adopted not only circumcision but also subincision(mimpi) as part of their rite of initiating young males into full tribal status. The Nukunu took pride in being "ritual purists". A. P. Elkin established that the Nukunu represented the most southeasterly tribe maintaining a matrilineal moiety system, involving two marriage moieties, the Mathari and the Kararru. The system was essentially akin to that existing among the Barngarla, Adnyamathanha and Wailpi.

Prenylcysteine lyase (PCLase) catalyzes the cleavage of prenylcysteine (a protein modification) to form an isoprenoid aldehyde and the freed cysteine residue on the protein target. The FAD is non-covalently bound to PCLase. Not many mechanistic studies have been done looking at the reactions of the flavin, but the proposed mechanism is shown below. A hydride transfer from the C1 of the prenyl moiety to FAD is proposed, resulting in the reduction of the flavin to FADH2.

And one > part of the indenture shall remain with the Jew, sealed with the seal of > him, to whom the money is lent, and the other part shall remain in the > common chest: wherein there shall be three locks and keys, whereof the two > Christians shall keep one key, and the two Jews another, and the clerks of > William of the Church of St Mary and of William of Chimilli shall keep the > third. And moreover, there shall be three seals to it, and those who keep > the seals shall put the seals thereto. > Moreover the clerks of the said William and William shall keep a roll of > the transcripts of all the charters, and as the charters shall be altered so > let the roll be likewise. For every charter there shall be three pence paid, > one moiety thereof by the Jews and the other moiety by him to whom the money > is lent; whereof the two writers shall have two pence and the keeper of the > roll the third.

Figure 6: Rolipram, highlighting the 3,4-dialkoxyphenyl moiety Figure 7: Common structure for PDE4-inhibiting thalidomide analogs The common structure for analogs that inhibit TNF-α via inhibition of PDE4 is prepared on the basis of hydrolysing the glutarimide ring of thalidomide. These analogs do not have an acidic chiral hydrogen, unlike thalidomide, and would therefore be expected to be chirally stable. On the phenyl ring, a 3,4-dialkoxyphenyl moiety (Figure 6) is a known pharmacophore in PDE4 inhibitors such as rolipram. Optimal activity is achieved with a methoxy group at the 4-position (X2) and a bigger group, such as cyclopentoxy at the 3-position carbon (X3). However the thalidomide PDE4 inhibitory analogs do not follow the SAR of rolipram analogs directly. For thalidomide analogs, an ethoxy group at X3 and a methoxy group at X2, with X1 being just a hydrogen, gave the highest PDE4 and TNF-α inhibition. Substitutes larger than diethoxy at the X2–X3 position had decreased activity. The effects of these substitutions seem to be mediated by steric effects.

If its OH group is eliminated or its position is changed the binding affinity is reduced. The triphenylethylene moiety and the side chain are required for tamoxifen binding to the ER, whereas for 4-hydroxytamoxifen, the side chain, and the phenyl-propene do not appear as crucial structural elements for binding to the ER. The basicity and length of the side chain do not seem to play a crucial role for tamoxifen binding affinity to the ER nor the β-ring of tamoxifen, but the stilbene moiety of tamoxifen is necessary for binding to the ER. The hydroxyl group is of particular importance for ER binding of 4-hydroxytamoxifen, and the ethyl side chain of tamoxifen protrudes out of the ligand-binding domain of the ER. Few tamoxifen users have suffered from increased rates of uterine cancer, hot flushes, and thromboembolisms. The drug can also cause hepatocarcinomas in rats. This is likely due to the ethyl group of the tamoxifen stilbene core that is subject to allylic oxidative activation causing DNA alkylation and strand scission.

Arg-66 and Arg-91 participate in hydrogen bonding with the carbonyl oxygen of green Eos's imidazolinone moiety. The His-62 side chain lies in an unpolar environment. Conversion from the green to red form depends on the presence of a histidine in the first position of the tripeptide HYG that forms the chromophore. When this histidine residue is substituted with M, S, T or L, Eos only emits bright green light and no longer acts as a photoconvertible fluorescent protein.

All four halogens are capable of acting as XB donors (as proven through theoretical and experimental data) and follow the general trend: F < Cl < Br < I, with iodine normally forming the strongest interactions. Dihalogens (I2, Br2, etc.) tend to form strong halogen bonds. The strength and effectiveness of chlorine and fluorine in XB formation depend on the nature of the XB donor. If the halogen is bonded to an electronegative (electron withdrawing) moiety, it is more likely to form stronger halogen bonds.

In molecular biology, glycoside hydrolase family 26 is a family of glycoside hydrolases. Glycoside hydrolases are a widespread group of enzymes that hydrolyse the glycosidic bond between two or more carbohydrates, or between a carbohydrate and a non-carbohydrate moiety. A classification system for glycoside hydrolases, based on sequence similarity, has led to the definition of >100 different families. This classification is available on the CAZy web site, and also discussed at CAZypedia, an online encyclopedia of carbohydrate active enzymes.

In molecular biology, glycoside hydrolase family 29 is a family of glycoside hydrolases. Glycoside hydrolases are a widespread group of enzymes that hydrolyse the glycosidic bond between two or more carbohydrates, or between a carbohydrate and a non-carbohydrate moiety. A classification system for glycoside hydrolases, based on sequence similarity, has led to the definition of >100 different families. This classification is available on the CAZy web site, and also discussed at CAZypedia, an online encyclopedia of carbohydrate active enzymes.

In molecular biology, glycoside hydrolase family 30 is a family of glycoside hydrolases. Glycoside hydrolases are a widespread group of enzymes that hydrolyse the glycosidic bond between two or more carbohydrates, or between a carbohydrate and a non-carbohydrate moiety. A classification system for glycoside hydrolases, based on sequence similarity, has led to the definition of >100 different families. This classification is available on the CAZy web site, and also discussed at CAZypedia, an online encyclopedia of carbohydrate active enzymes.

In molecular biology, glycoside hydrolase family 33 is a family of glycoside hydrolases. Glycoside hydrolases are a widespread group of enzymes that hydrolyse the glycosidic bond between two or more carbohydrates, or between a carbohydrate and a non-carbohydrate moiety. A classification system for glycoside hydrolases, based on sequence similarity, has led to the definition of >100 different families. This classification is available on the CAZy web site, and also discussed at CAZypedia, an online encyclopedia of carbohydrate active enzymes.

In molecular biology, glycoside hydrolase family 24 is a family of glycoside hydrolases. Glycoside hydrolases are a widespread group of enzymes that hydrolyse the glycosidic bond between two or more carbohydrates, or between a carbohydrate and a non-carbohydrate moiety. A classification system for glycoside hydrolases, based on sequence similarity, has led to the definition of >100 different families. This classification is available on the CAZy web site, and also discussed at CAZypedia, an online encyclopedia of carbohydrate active enzymes.

Pole, p.14, "Tawstock" mis-transcribed in 1791 edition from 17th-century manuscript as "Tavistocke", see Pole p.xv re transcription errors William III's son and heir was Reginald de Braose, who due to King John (1199–1216) having in 1208 confiscated his father's lands, never inherited the Braose moiety of the barony of Barnstaple. ;Loretta de Braose : Daughter of William de Braose (died 1211) and wife of Robert FitzPernel, Earl of Leicester (alias Robert de Beaumont, 4th Earl of Leicester(died c.1204)).

Loretta was childless and according to PolePole, pp.14, 389 gave Tawstock (2/3rds of the manor only according to Thorn) to her niece Matilda de Braose, daughter of the disinherited Reginald de Braose (son of William de Braose (died 1211)) and wife of Henry de Tracy (died 1274). Henry was the great-grandson of the second unnamed daughter and co-heiress of Alfred de Totnes, and thus had already inherited the other moiety of the feudal barony of Barnstaple.

A few years after, David I of Scotland confirmed the moiety "to be held as freely as in the time of his predecessors." In about 1270 the abbot and convent of Shrewsbury granted Little Bispham and Norbreck to the Abbot and convent of Dieulacres Abbey, who held the adjoining Rossall estate. After the Dissolution of the Monasteries, it was granted as part of Rossall estate, in 1553 to Thomas Fleetwood. Thus by then all three hamlets were owned by Thomas Fleetwood.

Canopus was identified as the moiety ancestor Waa "Crow" to some Koori people in southeastern Australia. The Boorong people of northwestern Victoria recalled that War (Canopus) was the brother of Warepil (Sirius), and that he brought fire from the heavens and introduced it to mankind. His wife was Collowgullouric War (Eta Carinae). The Pirt-Kopan-noot people of western Victoria told of Waa "Crow" falling in love with a queen, Gneeanggar "Wedge- tailed Eagle" (Sirius) and her six attendants (the Pleiades).

In molecular biology, glycoside hydrolase family 3 is a family of glycoside hydrolases. Glycoside hydrolases are a widespread group of enzymes that hydrolyse the glycosidic bond between two or more carbohydrates, or between a carbohydrate and a non-carbohydrate moiety. A classification system for glycoside hydrolases, based on sequence similarity, has led to the definition of over 100 different families. This classification is available on the CAZy web site, and also discussed at CAZypedia, an online encyclopedia of carbohydrate active enzymes.

In molecular biology, glycoside hydrolase family 31 is a family of glycoside hydrolases. Glycoside hydrolases are a widespread group of enzymes that hydrolyse the glycosidic bond between two or more carbohydrates, or between a carbohydrate and a non-carbohydrate moiety. A classification system for glycoside hydrolases, based on sequence similarity, has led to the definition of >100 different families. This classification is available on the CAZy web site, and also discussed at CAZypedia, an online encyclopedia of carbohydrate active enzymes.

In molecular biology, glycoside hydrolase family 32 is a family of glycoside hydrolases. Glycoside hydrolases are a widespread group of enzymes that hydrolyse the glycosidic bond between two or more carbohydrates, or between a carbohydrate and a non-carbohydrate moiety. A classification system for glycoside hydrolases, based on sequence similarity, has led to the definition of >100 different families. This classification is available on the CAZy web site, and also discussed at CAZypedia, an online encyclopedia of carbohydrate active enzymes.

In molecular biology, glycoside hydrolase family 35 is a family of glycoside hydrolases. Glycoside hydrolases are a widespread group of enzymes that hydrolyse the glycosidic bond between two or more carbohydrates, or between a carbohydrate and a non-carbohydrate moiety. A classification system for glycoside hydrolases, based on sequence similarity, has led to the definition of >100 different families. This classification is available on the CAZy web site, and also discussed at CAZypedia, an online encyclopedia of carbohydrate active enzymes.

In molecular biology, glycoside hydrolase family 38 is a family of glycoside hydrolases. Glycoside hydrolases are a widespread group of enzymes that hydrolyse the glycosidic bond between two or more carbohydrates, or between a carbohydrate and a non-carbohydrate moiety. A classification system for glycoside hydrolases, based on sequence similarity, has led to the definition of >100 different families. This classification is available on the CAZy web site, and also discussed at CAZypedia, an online encyclopedia of carbohydrate active enzymes.

In molecular biology, glycoside hydrolase family 39 is a family of glycoside hydrolases. Glycoside hydrolases are a widespread group of enzymes that hydrolyse the glycosidic bond between two or more carbohydrates, or between a carbohydrate and a non-carbohydrate moiety. A classification system for glycoside hydrolases, based on sequence similarity, has led to the definition of >100 different families. This classification is available on the CAZy web site, and also discussed at CAZypedia, an online encyclopedia of carbohydrate active enzymes.

In molecular biology, glycoside hydrolase family 4 is a family of glycoside hydrolases. Glycoside hydrolases are a widespread group of enzymes that hydrolyse the glycosidic bond between two or more carbohydrates, or between a carbohydrate and a non-carbohydrate moiety. A classification system for glycoside hydrolases, based on sequence similarity, has led to the definition of >100 different families. This classification is available on the CAZy web site, and also discussed at CAZypedia, an online encyclopedia of carbohydrate active enzymes.

In molecular biology, glycoside hydrolase family 73 is a family of glycoside hydrolases. Glycoside hydrolases are a widespread group of enzymes that hydrolyse the glycosidic bond between two or more carbohydrates, or between a carbohydrate and a non-carbohydrate moiety. A classification system for glycoside hydrolases, based on sequence similarity, has led to the definition of >100 different families. This classification is available on the CAZy web site, and also discussed at CAZypedia, an online encyclopedia of carbohydrate active enzymes.

In molecular biology, glycoside hydrolase family 7 is a family of glycoside hydrolases. Glycoside hydrolases are a widespread group of enzymes that hydrolyse the glycosidic bond between two or more carbohydrates, or between a carbohydrate and a non-carbohydrate moiety. A classification system for glycoside hydrolases, based on sequence similarity, has led to the definition of >100 different families. This classification is available on the CAZy web site, and also discussed at CAZypedia, an online encyclopedia of carbohydrate active enzymes.

In molecular biology, glycoside hydrolase family 70 is a family of glycoside hydrolases. Glycoside hydrolases are a widespread group of enzymes that hydrolyse the glycosidic bond between two or more carbohydrates, or between a carbohydrate and a non-carbohydrate moiety. A classification system for glycoside hydrolases, based on sequence similarity, has led to the definition of >100 different families. This classification is available on the CAZy web site, and also discussed at CAZypedia, an online encyclopedia of carbohydrate active enzymes.

In molecular biology, glycoside hydrolase family 71 is a family of glycoside hydrolases. Glycoside hydrolases are a widespread group of enzymes that hydrolyse the glycosidic bond between two or more carbohydrates, or between a carbohydrate and a non-carbohydrate moiety. A classification system for glycoside hydrolases, based on sequence similarity, has led to the definition of >100 different families. This classification is available on the CAZy web site, and also discussed at CAZypedia, an online encyclopedia of carbohydrate active enzymes.

In molecular biology, glycoside hydrolase family 72 is a family of glycoside hydrolases. Glycoside hydrolases are a widespread group of enzymes that hydrolyse the glycosidic bond between two or more carbohydrates, or between a carbohydrate and a non-carbohydrate moiety. A classification system for glycoside hydrolases, based on sequence similarity, has led to the definition of >100 different families. This classification is available on the CAZy web site, and also discussed at CAZypedia, an online encyclopedia of carbohydrate active enzymes.

In molecular biology, glycoside hydrolase family 76 is a family of glycoside hydrolases. Glycoside hydrolases are a widespread group of enzymes that hydrolyse the glycosidic bond between two or more carbohydrates, or between a carbohydrate and a non-carbohydrate moiety. A classification system for glycoside hydrolases, based on sequence similarity, has led to the definition of >100 different families. This classification is available on the CAZy web site, and also discussed at CAZypedia, an online encyclopedia of carbohydrate active enzymes.

In molecular biology, glycoside hydrolase family 68 is a family of glycoside hydrolases. Glycoside hydrolases are a widespread group of enzymes that hydrolyse the glycosidic bond between two or more carbohydrates, or between a carbohydrate and a non-carbohydrate moiety. A classification system for glycoside hydrolases, based on sequence similarity, has led to the definition of >100 different families. This classification is available on the CAZy web site, and also discussed at CAZypedia, an online encyclopedia of carbohydrate active enzymes.

In molecular biology, glycoside hydrolase family 67 is a family of glycoside hydrolases. Glycoside hydrolases are a widespread group of enzymes that hydrolyse the glycosidic bond between two or more carbohydrates, or between a carbohydrate and a non-carbohydrate moiety. A classification system for glycoside hydrolases, based on sequence similarity, has led to the definition of >100 different families. This classification is available on the CAZy web site, and also discussed at CAZypedia, an online encyclopedia of carbohydrate active enzymes.

In molecular biology, glycoside hydrolase family 62 is a family of glycoside hydrolases. Glycoside hydrolases are a widespread group of enzymes that hydrolyse the glycosidic bond between two or more carbohydrates, or between a carbohydrate and a non-carbohydrate moiety. A classification system for glycoside hydrolases, based on sequence similarity, has led to the definition of >100 different families. This classification is available on the CAZy web site, and also discussed at CAZypedia, an online encyclopedia of carbohydrate active enzymes.

In molecular biology, glycoside hydrolase family 63 is a family of glycoside hydrolases. Glycoside hydrolases are a widespread group of enzymes that hydrolyse the glycosidic bond between two or more carbohydrates, or between a carbohydrate and a non-carbohydrate moiety. A classification system for glycoside hydrolases, based on sequence similarity, has led to the definition of >100 different families. This classification is available on the CAZy web site, and also discussed at CAZypedia, an online encyclopedia of carbohydrate active enzymes.

In molecular biology, glycoside hydrolase family 65 is a family of glycoside hydrolases. Glycoside hydrolases are a widespread group of enzymes that hydrolyse the glycosidic bond between two or more carbohydrates, or between a carbohydrate and a non-carbohydrate moiety. A classification system for glycoside hydrolases, based on sequence similarity, has led to the definition of >100 different families. This classification is available on the CAZy web site, and also discussed at CAZypedia, an online encyclopedia of carbohydrate active enzymes.

In molecular biology, Glycoside hydrolase family 14 is a family of glycoside hydrolases. Glycoside hydrolases are a widespread group of enzymes that hydrolyse the glycosidic bond between two or more carbohydrates, or between a carbohydrate and a non-carbohydrate moiety. A classification system for glycoside hydrolases, based on sequence similarity, has led to the definition of >100 different families. This classification is available on the CAZy web site, and also discussed at CAZypedia, an online encyclopedia of carbohydrate active enzymes.

In molecular biology, Glycoside hydrolase family 16 is a family of glycoside hydrolases. Glycoside hydrolases are a widespread group of enzymes that hydrolyse the glycosidic bond between two or more carbohydrates, or between a carbohydrate and a non-carbohydrate moiety. A classification system for glycoside hydrolases, based on sequence similarity, has led to the definition of >100 different families. This classification is available on the CAZy web site, and also discussed at CAZypedia, an online encyclopedia of carbohydrate active enzymes.

In molecular biology, Glycoside hydrolase family 18 is a family of glycoside hydrolases. Glycoside hydrolases are a widespread group of enzymes that hydrolyse the glycosidic bond between two or more carbohydrates, or between a carbohydrate and a non-carbohydrate moiety. A classification system for glycoside hydrolases, based on sequence similarity, has led to the definition of >100 different families. This classification is available on the CAZy web site, and also discussed at CAZypedia, an online encyclopedia of carbohydrate active enzymes.

In molecular biology, Glycoside hydrolase family 19 is a family of glycoside hydrolases. Glycoside hydrolases are a widespread group of enzymes that hydrolyse the glycosidic bond between two or more carbohydrates, or between a carbohydrate and a non-carbohydrate moiety. A classification system for glycoside hydrolases, based on sequence similarity, has led to the definition of >100 different families. This classification is available on the CAZy web site, and also discussed at CAZypedia, an online encyclopedia of carbohydrate active enzymes.

In molecular biology, Glycoside hydrolase family 10 is a family of glycoside hydrolases. Glycoside hydrolases are a widespread group of enzymes that hydrolyse the glycosidic bond between two or more carbohydrates, or between a carbohydrate and a non-carbohydrate moiety. A classification system for glycoside hydrolases, based on sequence similarity, has led to the definition of >100 different families. This classification is available on the CAZy web site, and also discussed at CAZypedia, an online encyclopedia of carbohydrate active enzymes.

In molecular biology, Glycoside hydrolase family 11 is a family of glycoside hydrolases. Glycoside hydrolases are a widespread group of enzymes that hydrolyse the glycosidic bond between two or more carbohydrates, or between a carbohydrate and a non-carbohydrate moiety. A classification system for glycoside hydrolases, based on sequence similarity, has led to the definition of >100 different families. This classification is available on the CAZy web site, and also discussed at CAZypedia, an online encyclopedia of carbohydrate active enzymes.

In molecular biology, Glycoside hydrolase family 12 is a family of glycoside hydrolases. Glycoside hydrolases are a widespread group of enzymes that hydrolyse the glycosidic bond between two or more carbohydrates, or between a carbohydrate and a non-carbohydrate moiety. A classification system for glycoside hydrolases, based on sequence similarity, has led to the definition of >100 different families. This classification is available on the CAZy web site, and also discussed at CAZypedia, an online encyclopedia of carbohydrate active enzymes.

In molecular biology, Glycoside hydrolase family 2 is a family of glycoside hydrolases. Glycoside hydrolases are a widespread group of enzymes that hydrolyse the glycosidic bond between two or more carbohydrates, or between a carbohydrate and a non-carbohydrate moiety. A classification system for glycoside hydrolases, based on sequence similarity, has led to the definition of >100 different families. This classification is available on the CAZy web site, and also discussed at CAZypedia, an online encyclopedia of carbohydrate active enzymes.

In molecular biology, glycoside hydrolase family 20 is a family of glycoside hydrolases. Glycoside hydrolases are a widespread group of enzymes that hydrolyse the glycosidic bond between two or more carbohydrates, or between a carbohydrate and a non-carbohydrate moiety. A classification system for glycoside hydrolases, based on sequence similarity, has led to the definition of >100 different families. This classification is available on the CAZy web site, and also discussed at CAZypedia, an online encyclopedia of carbohydrate active enzymes.

In molecular biology, glycoside hydrolase family 25 is a family of glycoside hydrolases. Glycoside hydrolases are a widespread group of enzymes that hydrolyse the glycosidic bond between two or more carbohydrates, or between a carbohydrate and a non-carbohydrate moiety. A classification system for glycoside hydrolases, based on sequence similarity, has led to the definition of >100 different families. This classification is available on the CAZy web site, and also discussed at CAZypedia, an online encyclopedia of carbohydrate active enzymes.

In molecular biology, glycoside hydrolase family 28 is a family of glycoside hydrolases. Glycoside hydrolases are a widespread group of enzymes that hydrolyse the glycosidic bond between two or more carbohydrates, or between a carbohydrate and a non-carbohydrate moiety. A classification system for glycoside hydrolases, based on sequence similarity, has led to the definition of >100 different families. This classification is available on the CAZy web site, and also discussed at CAZypedia, an online encyclopedia of carbohydrate active enzymes.

In molecular biology, glycoside hydrolase family 42 is a family of glycoside hydrolases. Glycoside hydrolases are a widespread group of enzymes that hydrolyse the glycosidic bond between two or more carbohydrates, or between a carbohydrate and a non-carbohydrate moiety. A classification system for glycoside hydrolases, based on sequence similarity, has led to the definition of >100 different families. This classification is available on the CAZy web site, and also discussed at CAZypedia, an online encyclopedia of carbohydrate active enzymes.

In molecular biology, glycoside hydrolase family 43 is a family of glycoside hydrolases. Glycoside hydrolases are a widespread group of enzymes that hydrolyse the glycosidic bond between two or more carbohydrates, or between a carbohydrate and a non-carbohydrate moiety. A classification system for glycoside hydrolases, based on sequence similarity, has led to the definition of >100 different families. This classification is available on the CAZy web site, and also discussed at CAZypedia, an online encyclopedia of carbohydrate active enzymes.

In molecular biology, glycoside hydrolase family 45 is a family of glycoside hydrolases. Glycoside hydrolases are a widespread group of enzymes that hydrolyse the glycosidic bond between two or more carbohydrates, or between a carbohydrate and a non-carbohydrate moiety. A classification system for glycoside hydrolases, based on sequence similarity, has led to the definition of >100 different families. This classification is available on the CAZy web site, and also discussed at CAZypedia, an online encyclopedia of carbohydrate active enzymes.

In molecular biology, glycoside hydrolase family 46 is a family of glycoside hydrolases. Glycoside hydrolases are a widespread group of enzymes that hydrolyse the glycosidic bond between two or more carbohydrates, or between a carbohydrate and a non-carbohydrate moiety. A classification system for glycoside hydrolases, based on sequence similarity, has led to the definition of >100 different families. This classification is available on the CAZy web site, and also discussed at CAZypedia, an online encyclopedia of carbohydrate active enzymes.

In molecular biology, glycoside hydrolase family 48 is a family of glycoside hydrolases. Glycoside hydrolases are a widespread group of enzymes that hydrolyse the glycosidic bond between two or more carbohydrates, or between a carbohydrate and a non-carbohydrate moiety. A classification system for glycoside hydrolases, based on sequence similarity, has led to the definition of >100 different families. This classification is available on the CAZy web site, and also discussed at CAZypedia, an online encyclopedia of carbohydrate active enzymes.

In molecular biology, glycoside hydrolase family 49 is a family of glycoside hydrolases. Glycoside hydrolases are a widespread group of enzymes that hydrolyse the glycosidic bond between two or more carbohydrates, or between a carbohydrate and a non-carbohydrate moiety. A classification system for glycoside hydrolases, based on sequence similarity, has led to the definition of >100 different families. This classification is available on the CAZy web site, and also discussed at CAZypedia, an online encyclopedia of carbohydrate active enzymes.

In molecular biology, the glycoside hydrolase family 53 is a family of glycoside hydrolases. Glycoside hydrolases are a widespread group of enzymes that hydrolyse the glycosidic bond between two or more carbohydrates, or between a carbohydrate and a non-carbohydrate moiety. A classification system for glycoside hydrolases, based on sequence similarity, has led to the definition of >100 different families. This classification is available on the CAZy web site, and also discussed at CAZypedia, an online encyclopedia of carbohydrate active enzymes.

In molecular biology, glycoside hydrolase family 56 is a family of glycoside hydrolases. Glycoside hydrolases are a widespread group of enzymes that hydrolyse the glycosidic bond between two or more carbohydrates, or between a carbohydrate and a non-carbohydrate moiety. A classification system for glycoside hydrolases, based on sequence similarity, has led to the definition of >100 different families. This classification is available on the CAZy web site, and also discussed at CAZypedia, an online encyclopedia of carbohydrate active enzymes.

In molecular biology, glycoside hydrolase family 52 is a family of glycoside hydrolases. Glycoside hydrolases are a widespread group of enzymes that hydrolyse the glycosidic bond between two or more carbohydrates, or between a carbohydrate and a non-carbohydrate moiety. A classification system for glycoside hydrolases, based on sequence similarity, has led to the definition of >100 different families. This classification is available on the CAZy web site, and also discussed at CAZypedia, an online encyclopedia of carbohydrate active enzymes.

In molecular biology, glycoside hydrolase family 59 is a family of glycoside hydrolases. Glycoside hydrolases are a widespread group of enzymes that hydrolyse the glycosidic bond between two or more carbohydrates, or between a carbohydrate and a non-carbohydrate moiety. A classification system for glycoside hydrolases, based on sequence similarity, has led to the definition of >100 different families. This classification is available on the CAZy web site, and also discussed at CAZypedia, an online encyclopedia of carbohydrate active enzymes.

In molecular biology, glycoside hydrolase family 15 is a family of glycoside hydrolases. Glycoside hydrolases are a widespread group of enzymes that hydrolyse the glycosidic bond between two or more carbohydrates, or between a carbohydrate and a non-carbohydrate moiety. A classification system for glycoside hydrolases, based on sequence similarity, has led to the definition of >100 different families. This classification is available on the CAZy web site, and also discussed at CAZypedia, an online encyclopedia of carbohydrate active enzymes.

In molecular biology, glycoside hydrolase family 5 is a family of glycoside hydrolases. Glycoside hydrolases are a widespread group of enzymes that hydrolyse the glycosidic bond between two or more carbohydrates, or between a carbohydrate and a non-carbohydrate moiety. A classification system for glycoside hydrolases, based on sequence similarity, has led to the definition of >100 different families. This classification is available on the CAZy web site, and also discussed at CAZypedia, an online encyclopedia of carbohydrate active enzymes.

In molecular biology, glycoside hydrolase family 6 is a family of glycoside hydrolases. Glycoside hydrolases are a widespread group of enzymes that hydrolyse the glycosidic bond between two or more carbohydrates, or between a carbohydrate and a non-carbohydrate moiety. A classification system for glycoside hydrolases, based on sequence similarity, has led to the definition of >100 different families. This classification is available on the CAZy web site, and also discussed at CAZypedia, an online encyclopedia of carbohydrate active enzymes.

In molecular biology, glycoside hydrolase family 8 is a family of glycoside hydrolases. Glycoside hydrolases are a widespread group of enzymes that hydrolyse the glycosidic bond between two or more carbohydrates, or between a carbohydrate and a non-carbohydrate moiety. A classification system for glycoside hydrolases, based on sequence similarity, has led to the definition of >100 different families. This classification is available on the CAZy web site, and also discussed at CAZypedia, an online encyclopedia of carbohydrate active enzymes.

In molecular biology, glycoside hydrolase family 13 is a family of glycoside hydrolases. Glycoside hydrolases are a widespread group of enzymes that hydrolyse the glycosidic bond between two or more carbohydrates, or between a carbohydrate and a non-carbohydrate moiety. A classification system for glycoside hydrolases, based on sequence similarity, has led to the definition of >100 different families. This classification is available on the CAZy web site, and also discussed at CAZypedia, an online encyclopedia of carbohydrate active enzymes.

In molecular biology, glycoside hydrolase family 22 is a family of glycoside hydrolases. Glycoside hydrolases are a widespread group of enzymes that hydrolyse the glycosidic bond between two or more carbohydrates, or between a carbohydrate and a non-carbohydrate moiety. A classification system for glycoside hydrolases, based on sequence similarity, has led to the definition of >100 different families. This classification is available on the CAZy web site, and also discussed at CAZypedia, an online encyclopedia of carbohydrate active enzymes.

In molecular biology, glycoside hydrolase family 98 is a family of glycoside hydrolases. Glycoside hydrolases are a widespread group of enzymes that hydrolyse the glycosidic bond between two or more carbohydrates, or between a carbohydrate and a non-carbohydrate moiety. A classification system for glycoside hydrolases, based on sequence similarity, has led to the definition of >100 different families. This classification is available on the CAZy web site, and also discussed at CAZypedia, an online encyclopedia of carbohydrate active enzymes.

In molecular biology, glycoside hydrolase family 37 is a family of glycoside hydrolases. Glycoside hydrolases are a widespread group of enzymes that hydrolyse the glycosidic bond between two or more carbohydrates, or between a carbohydrate and a non-carbohydrate moiety. A classification system for glycoside hydrolases, based on sequence similarity, has led to the definition of >100 different families. This classification is available on the CAZy web site, and also discussed at CAZypedia, an online encyclopedia of carbohydrate active enzymes.

In molecular biology, glycoside hydrolase family 47 is a family of glycoside hydrolases. Glycoside hydrolases are a widespread group of enzymes that hydrolyse the glycosidic bond between two or more carbohydrates, or between a carbohydrate and a non-carbohydrate moiety. A classification system for glycoside hydrolases, based on sequence similarity, has led to the definition of >100 different families. This classification is available on the CAZy web site, and also discussed at CAZypedia, an online encyclopedia of carbohydrate active enzymes.

In molecular biology, glycoside hydrolase family 89 is a family of glycoside hydrolases. Glycoside hydrolases are a widespread group of enzymes that hydrolyse the glycosidic bond between two or more carbohydrates, or between a carbohydrate and a non-carbohydrate moiety. A classification system for glycoside hydrolases, based on sequence similarity, has led to the definition of >100 different families. This classification is available on the CAZy web site, and also discussed at CAZypedia, an online encyclopedia of carbohydrate active enzymes.

In molecular biology, glycoside hydrolase family 66 is a family of glycoside hydrolases. Glycoside hydrolases are a widespread group of enzymes that hydrolyse the glycosidic bond between two or more carbohydrates, or between a carbohydrate and a non-carbohydrate moiety. A classification system for glycoside hydrolases, based on sequence similarity, has led to the definition of >100 different families. This classification is available on the CAZy web site, and also discussed at CAZypedia, an online encyclopedia of carbohydrate active enzymes.

In molecular biology, glycoside hydrolase family 44 is a family of glycoside hydrolases. Glycoside hydrolases are a widespread group of enzymes that hydrolyse the glycosidic bond between two or more carbohydrates, or between a carbohydrate and a non-carbohydrate moiety. A classification system for glycoside hydrolases, based on sequence similarity, has led to the definition of >100 different families. This classification is available on the CAZy web site, and also discussed at CAZypedia, an online encyclopedia of carbohydrate active enzymes.

In molecular biology, glycoside hydrolase family 100 is a family of glycoside hydrolases. Glycoside hydrolases are a widespread group of enzymes that hydrolyse the glycosidic bond between two or more carbohydrates, or between a carbohydrate and a non-carbohydrate moiety. A classification system for glycoside hydrolases, based on sequence similarity, has led to the definition of >100 different families. This classification is available on the CAZy web site, and also discussed at CAZypedia, an online encyclopedia of carbohydrate active enzymes.

In molecular biology, glycoside hydrolase family 80 is a family of glycoside hydrolases. Glycoside hydrolases are a widespread group of enzymes that hydrolyse the glycosidic bond between two or more carbohydrates, or between a carbohydrate and a non-carbohydrate moiety. A classification system for glycoside hydrolases, based on sequence similarity, has led to the definition of >100 different families. This classification is available on the CAZy web site, and also discussed at CAZypedia, an online encyclopedia of carbohydrate active enzymes.

In molecular biology, glycoside hydrolase family 108 is a family of glycoside hydrolases. Glycoside hydrolases are a widespread group of enzymes that hydrolyse the glycosidic bond between two or more carbohydrates, or between a carbohydrate and a non-carbohydrate moiety. A classification system for glycoside hydrolases, based on sequence similarity, has led to the definition of >100 different families. This classification is available on the CAZy web site, and also discussed at CAZypedia, an online encyclopedia of carbohydrate active enzymes.

In molecular biology, glycoside hydrolase family 78 is a family of glycoside hydrolases. Glycoside hydrolases are a widespread group of enzymes that hydrolyse the glycosidic bond between two or more carbohydrates, or between a carbohydrate and a non-carbohydrate moiety. A classification system for glycoside hydrolases, based on sequence similarity, has led to the definition of >100 different families. This classification is available on the CAZy web site, and also discussed at CAZypedia, an online encyclopedia of carbohydrate active enzymes.

In molecular biology, glycoside hydrolase family 88 is a family of glycoside hydrolases. Glycoside hydrolases are a widespread group of enzymes that hydrolyse the glycosidic bond between two or more carbohydrates, or between a carbohydrate and a non-carbohydrate moiety. A classification system for glycoside hydrolases, based on sequence similarity, has led to the definition of >100 different families. This classification is available on the CAZy web site, and also discussed at CAZypedia, an online encyclopedia of carbohydrate active enzymes.

In molecular biology, glycoside hydrolase family 75 is a family of glycoside hydrolases. Glycoside hydrolases are a widespread group of enzymes that hydrolyse the glycosidic bond between two or more carbohydrates, or between a carbohydrate and a non-carbohydrate moiety. A classification system for glycoside hydrolases, based on sequence similarity, has led to the definition of >100 different families. This classification is available on the CAZy web site, and also discussed at CAZypedia, an online encyclopedia of carbohydrate active enzymes.

In molecular biology, glycoside hydrolase family 77 is a family of glycoside hydrolases. Glycoside hydrolases are a widespread group of enzymes that hydrolyse the glycosidic bond between two or more carbohydrates, or between a carbohydrate and a non-carbohydrate moiety. A classification system for glycoside hydrolases, based on sequence similarity, has led to the definition of >100 different families. This classification is available on the CAZy web site, and also discussed at CAZypedia, an online encyclopedia of carbohydrate active enzymes.

In molecular biology, glycoside hydrolase family 79 is a family of glycoside hydrolases. Glycoside hydrolases are a widespread group of enzymes that hydrolyse the glycosidic bond between two or more carbohydrates, or between a carbohydrate and a non-carbohydrate moiety. A classification system for glycoside hydrolases, based on sequence similarity, has led to the definition of >100 different families. This classification is available on the CAZy web site, and also discussed at CAZypedia, an online encyclopedia of carbohydrate active enzymes.

In molecular biology, glycoside hydrolase family 81 is a family of glycoside hydrolases. Glycoside hydrolases are a widespread group of enzymes that hydrolyse the glycosidic bond between two or more carbohydrates, or between a carbohydrate and a non-carbohydrate moiety. A classification system for glycoside hydrolases, based on sequence similarity, has led to the definition of >100 different families. This classification is available on the CAZy web site, and also discussed at CAZypedia, an online encyclopedia of carbohydrate active enzymes.

In molecular biology, glycoside hydrolase family 85 is a family of glycoside hydrolases. Glycoside hydrolases are a widespread group of enzymes that hydrolyse the glycosidic bond between two or more carbohydrates, or between a carbohydrate and a non-carbohydrate moiety. A classification system for glycoside hydrolases, based on sequence similarity, has led to the definition of >100 different families. This classification is available on the CAZy web site, and also discussed at CAZypedia, an online encyclopedia of carbohydrate active enzymes.

Additionally, it has been shown that the interaction between APP and kinesin is specific to the peptide sequence of APP. In a recent experiment involving transport of peptide- conjugated colored beads, controls were conjugated to a single amino acid, glycine, such that they display the same terminal carboxylic acid group as APP without the intervening 15-amino-acid sequence mentioned above. The control beads were not motile, which demonstrated that the terminal COOH moiety of peptides is not sufficient to mediate transport.

Substrate modification studies have demonstrated that the 3′-OH and 2′-OH moieties on the galactopyranose ring are essential for enzymatic recognition and hydrolysis. The 3′-hydroxy group is involved in initial binding to the substrate while the 2′- group is not necessary for recognition but needed in subsequent steps. This is demonstrated by the fact that a 2-deoxy analog is an effective competitive inhibitor (Ki = 10mM). Elimination of specific hydroxyl groups on the glucopyranose moiety does not completely eliminate catalysis.

This process produces free radicals that in turn damage susceptible proteins, resulting in the death of the parasite. In 2016 artemisinin was shown to bind to a large number of targets suggesting that it acts in a promiscuous manner. Artemisinin's endoperoxide moiety is however less sensitive to free iron(II) oxide, and therefore more active in the intraerythrocytic stages of Plasmodium falciparum. In contrast, clinical practice shows that unlike other antimalarials, artemisinin is active during all life cycle stages of the parasite.

Research aimed at development of renin inhibitors as potential antihypertensive agents had led to the discovery of compounds that blocked the action of this peptide cleaving enzyme. The amino acid sequence cleaved by renin was found to be fortuitously the same as that required to produce the HIV peptide coat. Structure–activity studies on renin inhibitors proved to be of great value for developing HIV protease inhibitors. Incorporation of an amino alcohol moiety proved crucial to inhibitory activity for many of these agents.

The structure of its polyketide chain extension has been shown to contain thirteen discrete PKS modules (a loading module and twelve extension modules). Proposed pathway for maklamicin biosynthesis in the Micormonospora sp. After passing through the extension domains the linear polyketide precursor to Maklamicin undergoes an intramolecular Diels-Alder reaction (IMDA) to form its trans- decalin motief. 1,3-bisphosphoglycerate is converted to glyceryl S-ACP and condenses onto the decalin-bearing polyketide intermediate to furnish an intermediate containing the premature tetronate moiety.

At some time before his death in 1100 King William II re-granted the barony of Barnstaple to Juhel de Totnes (died 1123/30), formerly feudal baron of Totnes.Sanders, p.104 Juhel's son and heir was Alfred de Totnes, who died sine prole some time before 1139, leaving two sisters as his co-heiresses each to a moiety of the barony: Aenor and a sister whose name is unknown,Sanders, p.104 wife of Henry de Tracy (died pre-1165).

In Australian Aboriginal mythology, Crow is a trickster, culture hero and ancestral being. In the Kulin nation in central Victoria he was known as Waa (also Wahn or Waang) and was regarded as one of two moiety ancestors, the other being the more sombre eaglehawk Bunjil. Legends relating to Crow have been observed in various Aboriginal language groups and cultures across Australia. To the Noongar people of southwestern Australia, the Australian raven was Waardar, "the Watcher" and was wily and unpredictable.

Tropone or 2,4,6-cycloheptatrien-1-one is an organic compound with some importance in organic chemistry as a non-benzenoid aromatic. The compound consists of a ring of seven carbon atoms with three conjugated alkene groups and a ketone group. The related compound tropolone (2-hydroxy-2,4,6-cycloheptatrien-1-one) has an additional alcohol (or an enol including the double bond) group next to the ketone. The tropone moiety can be found in biomolecules such as colchicine, stipitatic acid and hinokitiol.

The mitochondrial tyrosyl-tRNA synthetases (mt-YARSs) and in particular H. sapiens mt-YARS, likely originate from a YARS of eubacterial origin. Their C-terminal moiety includes both α-ACB and S4-like domains like the eubacterial YARSs and share a low sequence identity with their cytosolic relatives. The crystal structure of a complex between a recombinant H. sapiens mt-YARS, devoid of the S4-like domain, and an analog of tyrosyl-adenylate has been solved at 2.2 Å resolution.

The reaction can be extended to aliphatic aldehydes with base catalysis in the presence of thiazolium salts; the reaction mechanism is essentially the same... These compounds are important in the synthesis of heterocyclic compounds. The analogous 1,4-addition of an aldehyde to an enone is called the Stetter reaction. In biochemistry, the coenzyme thiamine is responsible for biosynthesis of acyloin-like compounds utilizing the benzoin addition. This coenzyme also contains a thiazolium moiety, which on deprotonation becomes a nucleophilic carbene.

There are several known causes of adrenergic storms; in the United States, cocaine overdose is the leading cause. Any stimulant drug has the capacity to cause this syndrome if taken in sufficient doses, but even non-psychotropic drugs can very rarely provoke a reaction. Monoamine oxidase inhibitors (MAOIs) are a class of drugs that inhibit the enzyme monoamine oxidase. This enzyme is responsible for breaking down many compounds; basically, anything with a primary amine moiety is likely to be oxidized by monoamine oxidase.

For example, sulfurous acid (SO2), sulfuric acid (SO3), and carbonic acid (CO2) are acidic oxides. An inorganic anhydride (a somewhat archaic term) is an acid anhydride without an organic moiety. Acidic oxides are not Brønsted–Lowry acids because they do not donate protons; however, they are Arrhenius acids because they increase the hydrogen ion concentration of water. For instance, carbon dioxide increases the hydrogen ion concentration of rain water (pH = 5.6) by a factor of 25 compared to pure water (pH = 7).

The seventh and eighth lines state that the eyes disagree with the heart and argue that they are capable of detecting of the beauty of a person. The third quatrain sets up the decision to be made about this 'battle'. Lines 9–10 explain that deciding this legal right of possession requires a jury of thoughts and these thoughts are all tenants of the heart. The jury decides the verdict and what share (moiety) the clear eye and dear heart will receive.

William's Tlingit name was Shgúndi and he was a member of the Raven moiety and of the Teeyhittaan clan. Tillie Paul was a teacher with Sheldon Jackson's Presbyterian mission among the Tlingit, later Sheldon Jackson College. William and his brothers all also attended the Carlisle Indian Industrial School in Carlisle, Pennsylvania. William and his brother Louis Paul (1887–1956) are considered foundational members of the Alaska Native Brotherhood (ANB) and in the 1920s extended its presence to every Native village in Southeast Alaska.

In this method the Pol a-synthesized primer is removed. Studies show that in the FEN1 suggest a ‘tracking; model where the nuclease moves from the 5’ flap to its base to preform cleavage. The Pol δ does not process a nuclease activity to cleave the displaced flap. The FEN1 cleaves the short flap immediately after they form. The cleavage is inhibited when the 5’ end of the DNA flap is blocked either with a complementary primer or a biotin-conjugated streptavidin moiety.

This bill allowed the Secretary of the Treasury to hire three persons to "discover and collect" unknown taxes to the United States government. If they collected they would receive 50% commission. Previously, acting Treasury Secretary William Adams Richardson, hired Sanborn as an independent tax collector on a 50 percent commission basis, known as a moiety. What Sanborn did instead was to take already existing tax cases, and put them on his contract, so when they came in, he would collect 50%.

Figure 4. Structure-activity relationship of thiourea derivatives Capsazepine (fig. 4a), the first competitive vanilloid antagonist, reported by Novartis group, was aimed at assessing the effect of conformational constraint on the lipophilic C-region of capsaicin. In capsazepine the amide bond of the capsaicin is replaced by a thiourea moiety and a propylidene linker between the aromatic vanillyl 2-carbon A ring and the B-linker amide nitrogen forces the aromatic ring in an orthogonal orientation with respect to the thiourea bond.

Benzylpenicillin, an example of a penam Penams are the primary skeleton structures that define the Penicillin subclass of the broader β-lactam family of antibiotics and related compounds. They are bicyclic ring systems containing a β-lactam moiety fused with a five-member thiazolidine ring. Due to ring strain and limitations on amide resonance, the structure is unstable and highly susceptible to catalytic cleaveage at the amide bond. Benzylpenicillin (Penicillin G) is the natural product parent that contains the penam structure.

SAR studies for quinuclidine amide have identified factors that are affecting the potency and affinity of these agonists. Para substitution on the quinuclidine ring and the 3-(R) configuration in the stereochemistry is favored. Enhanced activity is observed when a 5 membered ring is fused to aromatic moiety. Further enhancement is seen when the fused ring is able to supply electron resonance to the amide carbonyl whereas the activity will diminish when the fused ring contains a hydrogen bond donating atom.

Imprinting of arrays with hydrophilic-in- hydrophobic microwells is made possible using an innovative surface energy replication approach by means of a hydrophobic thiol-ene polymer formulation. In this polymer, hydrophobic-moiety-containing monomers self-assemble at the hydrophobic surface of the imprinting stamp, which results in a hydrophobic replica surface after polymerization. After removing the stamp, microwells with hydrophobic walls and a hydrophilic bottom are obtained. Such fast and inexpensive procedure can be utilised in digital microwell array technology toward diagnostic applications.

MMP activity can be decreased by binding to the cleavage site on the substrate e.g. catechin. Two molecular features of most MMP inhibitors are responsible for the affinity. One is a chelating moiety that interacts with the zinc ion and the other is a hydrophobic extension from the catalytic site that project into S1’ pocket (P1’ group) of the metalloproteinase. The structural difference MMPs’ is mainly in the S1’ side and by modifying the P1’ group, inhibitor selectivity can be developed.

Substitution of the heterocycle isoquinoline at the C1 position by a benzyl group provides 1‑benzylisoquinoline, the most widely examined of the numerous benzylisoquinoline structural isomers. The 1-benzylisoquinoline moiety can be identified within numerous compounds of pharmaceutical interest, such as moxaverine; but most notably it is found within the structures of a wide variety of plant natural products, collectively referred to as benzylisoquinoline alkaloids. This class is exemplified in part by the following compounds: papaverine, noscapine, codeine, morphine, apomorphine, berberine, tubocurarine.

Dansyl amide is a fluorescent dye that forms in a reaction between dansyl chloride and ammonia. It is the simplest representative of the class of dansyl derivatized amines, which are widely used in biochemistry and chemistry as fluorescent labels. The dansyl amide moiety is also called a dansyl group, and it can be introduced into amino acids or other amines in a reaction with dansyl chloride. The dansyl group is highly fluorescent, and it has a very high Stokes shift.

The dibenz[b,f][1,4]oxazepine moiety is present in the typical antipsychotic drug loxapine, but, unlike CR, loxapine is not reactive and is not an irritant. CR was first synthesised in 1962. CR can be delivered either as an aerosol or a solution in water, making it able to be used in water cannons, smoke grenades, or handheld spray cans. For smoke it is usually fired in canisters (LACR) that heat up, producing an aerosol cloud at a steady rate.

The inhibitors may work by mixed modalities, owing to affects on the protein, substrate or the diffusible species. The murzymes have a wide variety of substrates, as the reaction scheme is dependent on multiple modalities of interactions and outcomes. Comparison between classical enzyme mechanism and murburn catalysis mediated by diffusible species The new mechanism has been proposed as an explanation for electron/moiety transfers, catalysis and unusual observations in various in vitro and in vivo enzymatic, metabolic and physiological systems.

The unphosphorylated moiety of fingolimod, which is the predominant form of the drug in the body, is also an active molecule. Unphosphorylated fingolimod impairs the ability of cytotoxic CD8 T cells to kill their target cells by a different mechanism, which involves the arachidonic acid pathway, which is unrelated to sphigosine phosphate receptors. This has implications both for increasing susceptibility to viral infections as well as enhancing therapeutic efficacy in multiple sclerosis. Additionally, fingolimod shifts macrophages to an anti-inflammatory M2 phenotype.

ZB716, also known as fulvestrant-3-boronic acid, is a synthetic, steroidal, orally active antiestrogen which is under development for the treatment of estrogen receptor (ER)-positive metastatic breast cancer. The drug is a silent antagonist of the ERα (IC50 = 4.1 nM) as well as a selective estrogen receptor degrader (SERD). It is an analogue of fulvestrant in which the C3 hydroxyl group has been replaced with a boronic acid moiety. In accordance, the two drugs have similar pharmacodynamic properties.

The polymer is created from esterification reactions with fatty acids and contains 14 to 16 carbons per polyglycerol moiety. Sucrose monoesters are derived from the esterification of sucrose with a fatty acid ester or a fatty acid and it ideally should have a fatty acyl group ranging from 14 to 18 carbon atoms. Lastly, phospholipid such as lecithin, cephalin, and sphingomyelin can also be used as effective emulsifiers. In addition, some of the emulsifier act as a lubricant during the extrusion process.

St. John's Church was given by the sole surviving member of the Barton family, Miss Hazel Gowring Walker Barton. On 18 November 1952 the Trustees of the Church of England, Sydney Diocese and the Presbyterian Church NSW became the new owners as tenants in common, with equal moiety. The Presbyterian minister from Bowenfels was conducting regular Sunday services but the local Anglican Parish has not used the church regularly since the early 1980s. Regular Anglican workship ceased at the church in 1971.

This sulfhydryl can also be reversibly inhibited by NO in an elegant form of negative feedback. Homocysteine (a putative cardiovascular risk factor) mounts an oxidative attack on DDAH to form a mixed disulfide, inactivating the enzyme. By oxidizing a sulfhydryl moiety critical for DDAH activity, homocysteine and other risk factors cause ADMA to accumulate and to suppress nitric oxide synthase (NOS) activity. The critical role of DDAH activity in regulating NO synthesis in vivo was demonstrated using a transgenic DDAH mouse.

In a number of enzymes, the moiety that acts as a cofactor is formed by post-translational modification of a part of the protein sequence. This often replaces the need for an external binding factor, such as a metal ion, for protein function. Potential modifications could be oxidation of aromatic residues, binding between residues, cleavage or ring- forming. These alterations are distinct from other post-translation protein modifications, such as phosphorylation, methylation, or glycosylation in that the amino acids typically acquire new functions.

Due to his holding of a moiety of the barony of Newmarch, Russell became liable to provide one knight to the royal army for a fixed number of days per annum. Even before this grant it appears Russell held other lands by military tenure as in a Chancery document he is recorded as proffering knight service in 1213-14, but the size of his contingent is not legible.Sanders, Feudal Military Service, p. 156, note 19 quoting "Chancery Miscellaneous, C.47/5/11".

At that time, Ulubelen said > "...we can't recommend that women should be using these plants as an > abortive agent. We have so informed the pharmacist who sent them to us, and > I'm sure she's passing this information on to the villagers." 3-Benzoxepin does not occur naturally but is the skeletal moiety around which several natural products are built, including perilloxin (I) from Perilla frutescens var. crispa and tenual (II) and tenucarb (III) from Asphodeline tenuior, which Ulubelen helped to isolate.

Similar arginine residues in enzyme homologues (Arg370, Arg390) play analogous roles. Other homologues, such as in Sphingobacterium multivorum, feature the carboxy moiety bound to serine and methionine residues via water in place of arginine. Certain enzyme homologues, such as in S. multivorum as well as B. stolpii, are found to be associated with the inner cell membrane, thus resembling the eukaryotic enzymes. The B. stolpii homologue also features substrate inhibition by palmitoyl-CoA, a feature shared by the yeast and mammalian homologues.

Electrochemical experiments show that (+)-catechin oxidation mechanism proceeds in sequential steps, related with the catechol and resorcinol groups and the oxidation is pH-dependent. The oxidation of the catechol 3',4'-dihydroxyl electron-donating groups occurs first, at very low positive potentials, and is a reversible reaction. The hydroxyl groups of the resorcinol moiety oxidised afterwards were shown to undergo an irreversible oxidation reaction. The laccase/ABTS system oxidizes (+)-catechin to oligomeric products of which proanthocyanidin A2 is a dimer.

Mesoxalic acid, also called oxomalonic acid or ketomalonic acid, is an organic compound with formula C3H2O5 or HO−(C=O)3−OH. Mesoxalic acid is both a dicarboxylic acid and a ketonic acid. It readily loses two protons to yield the divalent anion , called mesoxalate, oxomalonate, or ketomalonate. These terms are also used for salts containing this anion, such as sodium mesoxalate, Na2C3O5; and for esters containing the −C3O5− or −O−(C=O)3−O− moiety, such as diethyl mesoxalate, (C2H5)2C3O5.

From this time forward the Tudors intermittently fought a private war with William Herbert and Walter Devereux. On 6 March 1453 Devereux's son, now Lord Ferrers, represented Herefordshire in Parliament in his place. On 20 March Walter Devereux and William Wylflete were placed under a recognizance of 200L and 50 marks to John, Bishop of St David's, and on 15 May the bishop granted them a moiety of Narberth Castle.Calendar of the Patent Rolls, Henry VI, Volume VI, 1452–1461.

Barentu/Barentoo or (older) Baraytuma is the other moiety of the Oromo people. The Barentu Oromo inhabit the eastern parts of the Oromia Region in the Zones of Mirab Hararghe or West Hararghe, Arsi Zone, Bale Zone, Debub Mirab Shewa Zone or South West Shewa, Dire Dawa region, the Jijiga Zone of the Somali Region, Administrative Zone 3 of the Afar Region, Oromia Zone of the Amhara Region, and are also found in the Raya Azebo Aanaas in the Tigray Region.

In addition, dolichols can be adducted to proteins as a posttranslational modification, a process in which branched carbohydrate trees are formed on a dolichol moiety and then transferred to an assembly of proteins to form a large glycoprotein in the rough endoplasmic reticulum. Dolichols are the major lipid component (14% by mass) of human substantia nigra (SN) neuromelanin. Dolichol phosphate was discovered at the University of Liverpool in the 1960s, although researchers did not know its function at the time of discovery.

Non-nucleoside phosphoramidites for 5'-modification of synthetic oligonucleotides. MMT = mono- methoxytrityl,(4-methoxyphenyl)diphenylmethyl.Non-nucleoside phosphoramidites are the phosphoramidite reagents designed to introduce various functionalities at the termini of synthetic oligonucleotides or between nucleotide residues in the middle of the sequence. In order to be introduced inside the sequence, a non-nucleosidic modifier has to possess at least two hydroxy groups, one of which is often protected with the DMT group while the other bears the reactive phosphoramidite moiety.

Fig.7: The structure of sitagliptin Sitagliptin (Januvia) has a novel structure with β-amino amide derivatives (Figure 7). Since sitagliptin has shown excellent selectivity and in vivo efficacy it urged researchers to inspect the new structure of DPP-4 inhibitors with appended β-amino acid moiety. Further studies are being developed to optimize these compounds for the treatment of diabetes. In October 2006 sitagliptin became the first DPP-4 inhibitor that got FDA approval for the treatment of type 2 diabetes.

The epitope XNAs target is an α-linked galactose moiety, Gal-α-1,3Gal (also called the α-Gal epitope), produced by the enzyme α-galactosyl transferase. Most non- primates contain this enzyme thus, this epitope is present on the organ epithelium and is perceived as a foreign antigen by primates, which lack the galactosyl transferase enzyme. In pig to primate xenotransplantation, XNAs recognize porcine glycoproteins of the integrin family. The binding of XNAs initiate complement activation through the classical complement pathway.

Galactokinase then phosphorylates α-D-galactose at the 1' hydroxyl group, yielding galactose-1-phosphate. In the third step, galactose-1-phosphate uridyltransferase catalyzes the reversible transfer of a UMP moiety from UDP-glucose to galactose-1-phosphate, generating UDP-galactose and glucose-1-phosphate. In the final Leloir step, UDP-glucose is regenerated from UDP-galactose by GALE; UDP-glucose cycles back to the third step of the pathway. As such, GALE regenerates a substrate necessary for continued Leloir pathway cycling.

Furthermore, the carboxylic acid moiety is a common feature of natural products and can also be prepared by relatively benign air oxidations. Additional benefits include the broad tolerance of functional groups, as well as the capacity to avoid the use of strong bases. An important elementary step in this reaction is protodecarboxylation or metalation to first convert the C–COOH bond to a C–H or C–M bond respectively. Shang R, Liu, L. Transition metal-catalyzed decarboxylative cross-coupling reactions.

The aromatization of acyclic precursors is rarer in organic synthesis, although it is a significant component of the BTX production in refineries. Among acyclic precursors, alkynes are relatively prone to aromatizations since they are partially dehydrogenated. The Bergman cyclization is converts an enediyne to a dehydrobenzene intermediate diradical, which abstracts hydrogen to aromatize. The enediyne moiety can be included within an existing ring, allowing access to a bicyclic system under mild conditions as a consequence of the ring strain in the reactant.

Fosfomycin is bactericidal and inhibits bacterial cell wall biogenesis by inactivating the enzyme UDP-N- acetylglucosamine-3-enolpyruvyltransferase, also known as MurA. This enzyme catalyzes the committed step in peptidoglycan biosynthesis, namely the ligation of phosphoenolpyruvate (PEP) to the 3'-hydroxyl group of UDP-N- acetylglucosamine. This pyruvate moiety provides the linker that bridges the glycan and peptide portion of peptidoglycan. Fosfomycin is a PEP analog that inhibits MurA by alkylating an active site cysteine residue (Cys 115 in the Escherichia coli enzyme).

The residues Arg-171 and Lys-190 are close to O4 and O2 of the thymine ring, respectively, and can help stabilize the intermediate state. The terminal amino group of Lys-190, which forms a hydrogen bond with the 3′-hydroxyl of the thymidine ribose moiety is also in place to donate a proton to thymine N1 during the intermediate state. As of late 2007, 6 structures have been solved for this class of enzymes, with PDB accession codes , , , , , and .

The tridecaketide itself contains an alpha-pyrone, a conjugated hexaene, and a single alkenyl moiety. Jaeger and Spiteller suggest that mycenaaurin A might function as a defense compound, since it exhibits antibacterial activity against the Gram-positive bacterium Bacillus pumilus. The chemical is only present in the fruit bodies, and not in the colorless mycelia. An earlier screening for antimicrobial activity in the fruit bodies revealed a weak ability to inhibit the growth of the fungi Candida albicans and Aspergillus fumigatus.

The unique position of the amine fluoride is based on their special molecular structure: the fluoride ion is bound to an organic fatty acid amine fragment. This is not the case for the inorganics fluorides such as sodium fluoride and sodium monofluorophosphate. Amine fluorides have a hydrophobic molecular moiety, the non-polar tail, with a hydrophilic component, the polar amine head. For this reason, they act like surfactants, reducing the surface tension of saliva, and forming a homogeneous film on all oral surfaces.

The ion is toxic to mammals as it causes blockage to iodine uptake in the thyroid. However it is degraded in the body over several hours. Compounds containing difluorophosphate may have it as a simple uninegative ion, it may function as a difluorophosphato ligand where it is covalently bound to one or two metal atoms, or go on to form a networked solid. It may be covalently bound to a non metal or an organic moiety to make an ester or an amide.

A lactone is eventually formed and the ring is opened by the use of a Grignard reagent to give (+)-trans-chrysanthemic acid. The preparation of (S)-pyrethrolone is essentially a 2 step synthesis. The starting material (S)-4-hydroxy-3-methyl-2-(2-propynyl)-2-cyclopenten-1-one (7) is also commercially available as the alcohol moiety of ETOC©. Tetrakis(triphenylphosphine)palladium(0), copper(I) iodide, triethylamine, and vinyl bromide are added to (7) to add two more carbons and form (8).

But even as the patent term nears expiration, pharmaceutical manufacturers employ several strategies to delay the entry of generic drugs to market. This could include by obtaining additional patents on other aspects of a drug, such as "its coating, salt moiety, formulation, and method of administration". An example of this strategy is the company AstraZeneca PLC (“AstraZeneca”) obtaining a patent on the enantiomer of omeprazole (Prilosec), a heartburn medication. The patent was obtained without significant evidence of the enantiomer's improved efficacy.

In 1303 he sought seisin of his moiety title of one-fourth part of eighteen manors in Northumberland, held in chief by the service of an eighth part of two knight's fees, arising from his transaction by fine (under royal licence) with John Yeland, but which had been subinfeudated and were claimed by the tenants under Custom of England.Calendarium Genealogicum, II, p. 646 (Hathi Trust); Calendar of Close Rolls, Edward II, I: 1307–1313 (1892), pp. 538-39 (Hathi Trust).

Marika painted over 40 works, many of which can be found in art collections of museums or private collectors. In the 1950s, he helped to create a commercial bark painting environment at the Yirrkala mission and collaborated in the creation of the Yirrkala Church Panels. One of Marika's figurative traits is that he often paints the Djang'kawu sisters, who are said to be the creator beings of the Dhuwa moiety. The Marika family see themselves as direct descendants of the Djang'kawu.

1: Structure of Routiennocin 1 Four chemical transformations happened in this tandem reaction. First, treating fragment A with n-butyllithium formed carbon anion that attacked the alkyliodide part of fragment B to generate intermediate C (step 1). Then a 3, 4-dihydropyran derivative D was formed through base-mediated elimination reaction on intermediate C (step 2). The protecting group on 1, 3-diol moiety in intermediate D was removed by acid treatment to give the diol product E (step 3).

Portentol is a complex polyketide first isolated in 1967 from the lichen Roccella portentosa and has since been extracted from various other lichen. It has exhibited moderate activity toward several cancer cell lines. Of greater interest is the structural skeleton and chemical space the molecule possesses, which were ultimately determined by detailed NMR studies and X-ray analysis. The spiro tricyclic core contains nine consecutive stereocenters, two of which are adjacent quaternary centers, and a β-keto-δ-lactone moiety.

Due to its electronic structure, iron has a very large coordination and organometallic chemistry. enantiomorphs of the ferrioxalate ion Many coordination compounds of iron are known. A typical six-coordinate anion is hexachloroferrate(III), [FeCl6]3−, found in the mixed salt tetrakis(methylammonium) hexachloroferrate(III) chloride. Complexes with multiple bidentate ligands have geometric isomers. For example, the trans- chlorohydridobis(bis-1,2-(diphenylphosphino)ethane)iron(II) complex is used as a starting material for compounds with the Fe(dppe)2 moiety.

Due to the esterases existing in the aqueous humour and ocular tissues, ibopamine can be rapidly hydrolysed to epinine which is the active molecule responsible for the mydriatic effect. The epinine, an analogue of dopamine, can stimulate dopamine receptors and to a lesser degree adrenergic receptors. Thus it is believed that epinine is the pharmacologically active moiety. It has been shown that the half-life of ibopamine is short to about 2 minutes in the aqueous humour owing to the fast hydrolysis.

Transducin is activated by metarhodopsin II, a conformational change in rhodopsin caused by the absorption of a photon by the rhodopsin moiety retinal. The light causes isomerization of retinal from 11-cis to all-trans. Isomerization causes a change in the opsin to become metarhodopsin II. When metarhodopsin activates transducin, the guanosine diphosphate (GDP) bound to the α subunit (Tα) is exchanged for guanosine triphosphate (GTP) from the cytoplasm. The α subunit dissociates from the βγ subunits (Tβγ.) Activated transducin α-subunit activates cGMP phosphodiesterase.

The chemical structure of finafloxacin has been described as a "fluorinated quinolone derivative with 8-cyano-substituent and 7-pyrrolo-oxazinyl moiety." Its low isoelectric point (pH 6.7) is lower than the isoelectric point of another fluoroquinolone class antibiotic called ciprofloxacin (pH 7.4), which accounts for finafloxacin's superior activity at low pH (5.0–6.0). There are some notable differences between the chemistry of finafloxacin and related fluoroquinolones. For example, the 8-cyano-substituent is not found in ciprofloxacin, and moxifloxacin has an 8-methoxy-substituent instead.

The human body can employ cyanide-like umpolung reactivity without having to rely on the toxic cyanide ion. Thiamine (which itself is an N-heterocyclic carbene) pyrophosphate (TPP) serves a functionally identical role. The thiazolium ring in TPP is deprotonated within the hydrophobic core of the enzyme, resulting in a carbene which is capable of umpolung. Deprotonation of thiazole moiety in thiamine pyrophosphate results in ambivalent chemical reactivity Enzymes which use TPP as a cofactor can catalyze umpolung reactivity, such as the decarboxylation of pyruvate.

The remaining 1/3rd of the manor of Tawstock was given, apparently by Loretta, to Buckland Priory in Somerset, for the support of the sisters of the Order of St John of Jerusalem. In 1213 King John granted the Braose moiety which he had confiscated from William de Braose to Henry de Tracy (died 1274),Sanders, p.105 the husband of his granddaughter Matilda de Braose. Thus were the two moieties of the barony re-united together and with 2/3rds of the manor of Tawstock.

Vinyltriethoxysilane and the related vinyltrimethoxysilane are using as monomers and comonomer for polymers such as ethylene-vinyltrimethoxysilane and ethylene-vinyl acetate- vinyltrimethoxysilane. Vinyltrialkoxysilanes are also used as cross-linking agents during the manufacture of cross-linked polyethylene (PEX). The alkoxysilane moiety is reactive toward water, and in the presence of moisture, it forms silicon-oxygen-silicon bonds that cross-link the material to cure it. Moisture-curable polymers are used as electrical insulation in some kinds of cables and for water pipe in under-floor heating installations.

While the details of the mechanism are uncertain, the stereochemical retention is achieved off a double displacement reaction. Studies of E. coli lactase have proposed that hydrolysis is initiated when a glutamate nucleophile on the enzyme attacks from the axial side of the galactosyl carbon in the β-glycosidic bond. The removal of the D-glucose leaving group may be facilitated by Mg-dependent acid catalysis. The enzyme is liberated from the α-galactosyl moiety upon equatorial nucleophilic attack by water, which produces D-galactose.

In 1799 and 1800, Isaac's parents and brother Little George all died within a few months of each other. While ill, the family members consulted a black conjurer living in Buckingham County. (This showed the persistence of African traditions within the slave community.) Shortly after Great George's death, Thomas Jefferson gave Isaac $11, the value of "his moiety of a colt left him by his father." In 1812 an Isaac belonging to Thomas Mann Randolph ran away and was caught and imprisoned in Bath County.

RNaseH enzymes are the primary proteins responsible for the dissolution of R-loops, acting to degrade the RNA moiety in order to allow the two complementary DNA strands to anneal. Research over the past decade has identified more than 50 proteins that appear to influence R-loop accumulation, and while many of them are believed to contribute by sequestering or processing newly transcribed RNA to prevent re-annealing to the template, mechanisms of R-loop interaction for many of these proteins remain to be determined.

The manor lands were split, Reverend William Consett taking the eastern part of the estate, upon which he built the elegant and commodious Normanby House, which became known as the Manor House. The other brother, Captain Matthew Consett, took the part of the manor with the ancient Hall. The Hall with a moiety of the estate was purchased in 1748, by Ralph Jackson, on the death of Captain Consett. The common fields around it were enclosed, in 1790, to become parkland for the mansion.

RH-34 is a compound which acts as a potent and selective partial agonist for the 5-HT2A serotonin receptor subtype. It was derived by structural modification of the selective 5-HT2A antagonist ketanserin, with the 4-(p-fluorobenzoyl)piperidine moiety replaced by the N-(2-methoxybenzyl) pharmacophore found in such potent 5-HT2A agonists as NBOMe-2C-B and NBOMe-2C-I. This alteration was found to retain 5-HT2A affinity and selectivity, but reversed activity from an antagonist to a moderate efficacy partial agonist.Ralf Heim.

Holy Trinity, Bottisham. Beckingham appears to have been one of if not the richest man in the parish, although he was still only a free tenant of Bottisham rather than a lord of the manor. In 1275, he bought a moiety of in Bottisham, Cambridgeshire, constituting a quarter of the "Deresley fee", a half of a knight's fee held from the lord of the manor of Bottisham (then Maud de Lacy, Countess of Hertford and Gloucester). These holdings were later recognized as the manor of Vauxes.

Chemotactic range fitting Chemotactic range fitting: chemotactic responses elicited by the ligand-receptor interactions are distinguished generally upon the optimal effective concentration(s) of the ligand. Nevertheless, correlation of the amplitude elicited and ratio of the responder cells compared to the total number are also characteristic features of the chemotactic signaling. Investigations of ligand families (e.g. amino acids or oligopeptides) proved that there is a fitting of ranges (amplitudes; number of responder cells) and chemotactic activities: chemoattractant moiety is accompanied with wide, while chemorepellent character narrow ranges.

Chemokinesis is chemically prompted kinesis, a motile response of unicellular prokaryotic or eukaryotic organisms to chemicals that cause the cell to make some kind of change in their migratory/swimming behaviour. Changes involve an increase or decrease of speed, alterations of amplitude or frequency of motile character, or direction of migration. However, in contrast to chemotaxis, chemokinesis has a random, non-vectorial moiety, in general. Due to the random character, techniques dedicated to evaluate chemokinesis are partly different from methods used in chemotaxis research.

Ribose is referred to as the "molecular currency" because of its involvement in intracellular energy transfers. For example, nicotinamide adenine dinucleotide (NAD), flavin adenine dinucleotide (FAD), and nicotinamide adenine dinucleotide phosphate (NADP) all contain the -ribofuranose moiety. They can each be derived from -ribose after it is converted to -ribose 5-phosphate by the enzyme ribokinase. NAD, FAD, and NADP act as electron acceptors in biochemical redox reactions in major metabolic pathways including glycolysis, the citric acid cycle, fermentation, and the electron transport chain.

She was of the Raven moiety, of the Y'akwə'lanas lineage, and of the Shark House (Q'ad Nas), with crests that included Shark, Two-Finned Killerwhale, and Brown Bear. She married Robert Davidson (1880–1969), a Haida, on February 23, 1911, and had thirteen children. Her daughter Primrose Adams, also an artist, was the 2011 recipient of the Creative Lifetime Achievement Award for First Nations' Art. In the 1960s she was consultant on Haida culture and Masset history to the writer Christie Harris, author of Raven's Cry.

Dining room Hall i' th' Wood is an early 16th-century manor house in Bolton, Greater Manchester, England. It is a Grade I listed building and is currently used as a museum by Bolton Metropolitan Borough Council. It was the manor house for the moiety of the Tonge with Haulgh township held by the Brownlows in the 16th century. The original building is timber framed and has a stone flagged roof; there were later additions to the house, built from stone, in 1591 and 1648.

Arg-161 interacts with the C1 carbonyl of MVAPP, and Asn-17 is important for hydrogen bonding with this same arginine residue. Asp-305 is positioned about 4 Å from the C3 hydroxyl on MVAPP and acts as a general base catalyst in the active site. Ser-127 aids in orientation of the phosphoryl chain for the phosphate transfer to MVAPP. Mevalonate diphosphate decarboxylase also has a phosphate-binding loop (‘P-loop’) where amino acid residues provide key interactions that stabilize the nucleotide triphosphoryl moiety.

As all the members of a band were related, marriage between a man and a woman within the same band was forbidden. Bands were patrilineal and patrilocal: a woman always lived with her husband's band following her marriage. Each band was also composed of two exogamous moieties, the Karuru and Mattari, which traced their descent matrilineally to an ancestral totemic being. All the children of a marriage would take their mother's moiety as children were considered to have "inherited" their "flesh and blood" from their mothers alone.

The bidentate ligand contains two titaniums, binols, and an aromatic diamine connecting moiety, gave enantiomeric excesses of up to 99%.Kii, S., Maruoka, K., Tetrahedron Lett., 2001, 42, 1935-1939. Improved stereoselectivity is proposed to come from double activation of the carbonyl from the titaniums, a hypothesis supported by C13 NMR and IR spectroscopy studies on 2,6-γ-pyrone substrate. The most convincing evidence that the M-O rotation is restricted comes from NOE NMR studies on trans-4-methoxy-3-buten-2-one.

Diazo The diazo group is an organic moiety consisting of two linked nitrogen atoms (azo) at the terminal position. Overall charge neutral organic compounds containing the diazo group bound to a carbon atom are called diazo compounds or diazoalkanesThe term diazoalkane is used by some authors to refer to any substituted diazomethane (i.e., all diazo compounds). However, other authors use the term to refer exclusively to diazo compounds with alkyl substituents that do not contain other functional groups (which would exclude compounds like diphenyldiazomethane or ethyl diazoacetate).

A commercially relevant diazo compound is ethyl diazoacetate (N2CHCOOEt). A group of isomeric compounds with only few similar properties are the diazirines, where the carbon and two nitrogens are linked as a ring. Four resonance structures can be drawn:F.A. Carey R.J. Sundberg Advanced Organic Chemistry, 2nd Edition :Diazo resonance structures Compounds with the diazo moiety should be distinguished from diazonium compounds, which have the same terminal azo group but bear an overall positive charge, and azo compounds in which the azo group bridges two organic substituents.

Excessive collagen degradation may be associated with cancer metastasis, skin ageing, arthritis, and osteoporosis. CHPs can target tissues undergoing remodelling based on their ability to bind to degraded and unfolded collagen strands through triple helix formation. As a targeting moiety, CHPs offer great potential in histopathology, diagnostics, and drug delivery for a wide range of diseases. Most methods for the evaluation of collagen denaturation in disease states are indirect, such as detecting matrix metalloproteinase (MMP) activity or quantifying collagen peptide fragments in urine, serum, or synovial fluid.

The protein encoded by AMT catalyzes the release of ammonia and the transfer of a methylene carbon unit to a tetrahydrofolate moiety. The aminomethyl intermediate is the product of the decarboxylation of glycine catalyzed by P-protein. In the reverse reaction, T-protein catalyzes the formation of the H-protein-bound aminomethyl lipoate intermediate from 5,10-CH2-H4folate, ammonia, and reduced H-protein via an ordered Ter Bi mechanism, in which reduced H-protein is the first substrate to bind followed by 5,10-CH2-H4folate and ammonia.

Deoxyadenosine (symbol dA or dAdo) is a deoxyribonucleoside. It is a derivative of the nucleoside adenosine, differing from the latter by the replacement of a hydroxyl group (-OH) by hydrogen (-H) at the 2' position of its ribose sugar moiety. Deoxyadenosine is the DNA nucleoside A, which pairs with deoxythymidine (T) in double-stranded DNA. In absence of adenosine deaminase (ADA) it accumulates in T lymphocytes and kills these cells resulting in a genetic disorder known as adenosine deaminase severe combined immunodeficiency disease (ADA-SCID).

Gladiolin is a polyketide natural product produced by Burkholderia gladioli BCC0238 which is isolated from sputum of cystic fibrosis patients. It was found to be a novel macrolide antibiotic which presented an activity against Mycobacterium tuberculosis. Gladiolin is structurally much more stable than its analogue etnangien as an efficient myxobacterial RNA polymerase inhibitor due to the lack of highly labile hexaene moiety in gladiolin. The good activity and high stability of gladiolin offers it the potential for further development as an antibiotic against antibiotic-resistant M. tuberculosis.

There is probably not another virtuoso, whether with instrument or voice (Liszt alone excepted), who could have excited a moiety of the enthusiasm, or gathered a fragment of the dollars, which Thalberg has excited and gathered.Quoted after: Lott: From Paris to Peoria, p.159. The "unexpected close" referred to the announcement in June 1858 in Chicago that Thalberg would make only one of three scheduled appearances before immediately returning to Europe. In fact, Thalberg did not even perform at that concert, but very hastily left.

368x368pxThe Si=P moiety of phosphasilene has been reported to demonstrate small molecule activation reactivities analogous to those observed in Si=Si, P=C, and other heavier alkene analogues. For example, phosphasilene with silyl substituents has been shown to activate white phosphorus (P4) under relatively mild reaction conditions to form 1,2,3-triphospha-4-silabicyclo[1.1.0]butanes, which is similar to disilenes' reactivity. Analogous to the behavior of phosphaalkenes, phosphasilene can also activate chalcogens such as S8 and Te to form unstable three-membered ring compounds.

Molybdopterin synthase sulfurtransferase (, adenylyltransferase and sulfurtransferase MOCS3, Cnx5 (gene), molybdopterin synthase sulfurylase) is an enzyme with systematic name persulfurated L-cysteine desulfurase:(molybdopterin-synthase sulfur-carrier protein)-Gly-Gly sulfurtransferase. This enzyme catalyses the following chemical reaction : [molybdopterin-synthase sulfur-carrier protein]-Gly-Gly-AMP + [cysteine desulfurase]-S-sulfanyl-L-cysteine \rightleftharpoons AMP + [molybdopterin- synthase sulfur-carrier protein]-Gly-NH-CH2-C(O)SH + cysteine desulfurase The enzyme transfers sulfur to form a thiocarboxylate moiety on the C-terminal glycine of the small subunit of molybdopterin synthase.

Another compound with sunitinib heterocyclic moiety and a pyrrole side chain has very good VEGFR-2 potency, with an IC50 of 65 nM. N-indol-1-amide compound is a possible anti-tumor drug in combination with other anticancer treatment and has an IC50 value of 31 nM. There are many indol derivatives with different side chains that target multiple kinases and take part in several pathways in tumor development. Intedanib is a multiple tyrosine kinase inhibitor and is the first drug to treat idiopathic pulmonary fibrosis.

Davies, S. G.; Donohoe, T. J. Synlett 1993, 323. (3)File:CrAreneMech2.png Finally, the chromium tri(carbonyl) moiety serves as a sterically bulky group in reactions of arene chromium complexes, preventing the approach of a reagent endo to chromium. In addition, ortho-substituted aromatic aldehydes and styrenes prefer to adopt a conformation in which the doubly bound oxygen or carbon is pointed away from the ortho substituent. As a result, only one face of the double bond is exposed on the exo face of the aromatic ring.

The sisters were from Ngukurr and they were part of the Wawalak clan which belongs to the Dua moiety, one of the many Australian aboriginal kinships. Most commonly, the elder sister, Waimariwi, is pregnant while the younger one, Boaliri, is going through early puberty. But in other versions, the younger sister is pregnant while the elder sister already has a baby that is around 2/3 years old. It is unclear what gender the baby is as it is addressed as both male and female.

Figure 3 show the ketonization results for the two Phenyl- Pyridyl diastereomers. In the exo-pyridyl isomer on the left, the usual steric hindrance control blocks protonation from above. That is, the phenyl group is positioned directly above the enolic alpha carbon and protonation must occur from below. In contrast, in the case of the endo pyridyl isomer on the right, the basic pyridyl moiety proves capable of picking up the proton first and then delivering it to the alpha-carbon from this upper, hindered side.

In the retina, this conversion induces a conformational change in the surrounding opsin protein pigment, leading to signaling through the G protein transducin. Retinaldehyde also forms a part of bacteriorhodopsin, a light-induced proton pump found in some archaea. Experimentally, it is possible to replace 11-cis retinaldehyde by perfusing retinal tissue preparations with retinaldehyde derivatives. Selective modification of the retinaldehyde structure, particularly the density of electrons in the π-orbitals, can lead to insights into the interaction between the retinaldehyde moiety and the surrounding pigment protein.

A Zhan catalyst is a type of ruthenium-based organometallic complex used in olefin metathesis. This class of chemicals is named after the chemist who first synthesized them, Zheng-Yun J. Zhan. These catalysts are ruthenium complexes with functionally substituted alkoxybenzylidene carbene ligands, which can be chemically bonded to the surface of resins, PEG chains, and polymers. Like the structurally similar Hoveyda-Grubbs catalyst, they contain an isopropoxystyrene moiety, but include an extra electron-withdrawing sulfonamide group attached to the carbon para to the phenol oxygen.

These activities of sirtuins are particularly interesting because of their importance in the regulation of aging. Other NAD-dependent enzymes include bacterial DNA ligases, which join two DNA ends by using NAD as a substrate to donate an adenosine monophosphate (AMP) moiety to the 5' phosphate of one DNA end. This intermediate is then attacked by the 3' hydroxyl group of the other DNA end, forming a new phosphodiester bond. This contrasts with eukaryotic DNA ligases, which use ATP to form the DNA-AMP intermediate.

He classified these as the Yan-nhaŋu, Djinang, Djinba, Djaŋu, Dangu, Rembarrnga, Ritharngu, Dhuwal and the Dhuwala. Warner had deployed the term "Murngin" to denote a group of peoples who shared, in his analysis, a distinctive form of kinship organisation, describing their marriage rules, subsection system and kinship terminology. Other researchers in the field quickly contested his early findings. T. Theodor Webb argued that Warner's Murngin actually referred to one moiety, and could only denote a Yiritcha mala, and dismissed Warner's terminology as misleading.

A substitution reaction using either sodium dithionite () or sodium sulfide with sodium hydroxide will allow the replacement of the bromo substituent with a thiol functional group. 350px The alternative strategy is to form the mercaptan before introducing the N-oxide moiety. 2-Mercaptopyridine was originally synthesized in 1931 by heating 2-chloropyridine with calcium bisulfide, an approach similar that first used to prepare pyrithione. The analogous thiourea approach via a uronium salt was reported in 1958 and provides a more convenient route to 2-mercaptopyridine.

William Caslon I founded the Caslon Foundry in 1739, based on what previously had been Godfrey Head's (1685–1700). The other half of that business was purchased by John James, son of Thomas James. John James in the period 1716–1764 also built up by purchase what became the leading English type foundry of the 18th and early 19th centuries. He acquired moiety of half of Robert Mitchell and Jacob Ilive in 1740. A later and important purchase was the foundry of Thomas Grover in 1758.

In addition, some fluorescent Pseudomonads lack apparent homologs of these genes, further calling into question whether this is the function of these genes. This is consistent with reports that pvdL combines coenzyme A to a myristic acid moiety, then adds a glutamate, D-tyrosine, and L-2,4-diaminobutyric acid (DAB). An alternate biosynthetic pathway suggests that pvdL incorporates glutamate, 2,4,5-trihydroxyphenylalanine and L-2,4-daminobutyric acid instead. This latter is supported by the identification of incorporation of a radiolabeled tyrosine into either pyoverdine or pseudoverdine.

Comparison of these inhibitors with the natural substrates of the enzyme, cAMP and cGMP reveal some common characteristics of the molecules. The main characteristic of all the molecules is the flat moiety comprising at least two fused ring structures, a six atom ring and a five atom ring. This ring system in cGMP and cAMP is a purine ring system, and the same is true for EHNA and PDP. Bay 60-7550 and oxindole lack the purine core but do possess a related ring system.

Important structure-activity relationship: 1\. Strict steric constraint exists around the pyrrolidine ring of cyanopyrrolidine-based inhibitors, with only hydrogen, fluoro, acetylene, nitrile, or methano substitution permitted. 2\. Presence of a nitrile moiety on the pyrrolidine ring is critical to achieving potent activity Also, systematic SAR investigation has shown that the ring size and stereochemistry for the P2 position is quite conditioned. A 5-membered ring and L-configuration has shown better results than a 4-membered or 6-membered ring with D-configuration.

Lincosamides prevent bacterial replication in a bacteriostatic mechanism by interfering with the synthesis of proteins. In a mechanism similar to macrolides and streptogramin B, lincosamides bind close to the peptidyl transferase center on the 23S portion of the 50S subunit of bacterial ribosomes. High resolution X-ray structures of clindamycin and ribosomal subunits from bacterium have previously revealed exclusive binding to the 23S segment of the peptidyl transferase cavity. Binding is mediated by the mycarose sugar moiety which has partially overlapping substrates with peptidyl transferase.

With exception of the spermidine synthases from Thermotoga maritimum and from Escherichia coli, which accept different kinds of polyamines, all enzymes are highly specific for putrescine. No known spermidine synthase can use S-adenosyl methionine. This is prevented by a conserved aspartatyl residue in the active site, which is thought to repel the carboxyl moiety of S-adenosyl methionine. The putrescine-N-methyl transferase whose substrates are putrescine and S-adenosyl methionine and which is evolutionary related to the spermidine synthases lacks this aspartyl residue.

Indole-3-acetaldehyde belongs to the class of organic compounds known as indoles. These are compounds containing an indole moiety, which consists of pyrrole ring fused to benzene to form 2,3-benzopyrrole. Indole-3-acetaldehyde is a substrate for retina-specific copper amine oxidase, aldehyde dehydrogenase X (mitochondrial), amine oxidase B, amiloride-sensitive amine oxidase, aldehyde dehydrogenase (mitochondrial), fatty aldehyde dehydrogenase, 4-trimethylaminobutyraldehyde dehydrogenase, aldehyde dehydrogenase (dimeric NADP-preferring), aldehyde dehydrogenase family 7 member A1, amine oxidase A, aldehyde dehydrogenase 1A3 and membrane copper amine oxidase.

Curacin A is a hybrid polyketide synthase (PKS)/nonribosomal peptide synthase (NRPS) derived natural product produced isolated from the cyanobacterium Lyngbya majuscula. Curacin A belongs to a family of natural products including jamaicamide, mupirocin, and pederin that have an unusual terminal alkene. Additionally, Curacin A contains a notable thiazoline ring and a unique cyclopropyl moiety, which is essential to the compound's biological activity. Curacin A has been characterized as potent antiproliferative cytotoxic compound with notable anticancer activity for several cancer lines including renal, colon, and breast cancer.

Deoxyhypusine synthase is an enzyme that in humans is encoded by the DHPS gene. The unusual amino acid hypusine is formed posttranslationally and is only found in a single cellular protein, eukaryotic translation initiation factor 5A. In the first step of hypusine biosynthesis, deoxyhypusine synthase catalyzes the NAD-dependent transfer of the butylamine moiety of spermidine to the epsilon-amino group of a specific lysine residue of the EIF5A precursor protein to form the intermediate deoxyhypusine residue. This gene consists of nine exons spanning 6.6 kb.

The presence of octamer arginine residues allows cell membrane transduction of various cargo molecules including peptides, DNA, siRNA, and contrast agents. However, the ability of cross membrane is not unidirectional; arginine-based CPPs are able to enter-exit the cell membrane, displaying an overall decreasing concentration of contrast agent and a decrease of magnetic resonance (MR) signal in time. This limits their application in vivo. To solve this problem, contrast agents with disulfide, reversible bond between metal chelate and transduction moiety enhance the cell-associated retention.

On the same day, Cutler and Sargent for themselves and associates transferred to William Duer, then Secretary of the Treasury Board, and his associates one equal moiety of the Scioto tract of land mentioned in the second contract. Both parties were to be equally interested in the sale of the land, and were to share equally any profit or loss. But, the Scioto Company interest was speculative, and their contract lapsed before they purchased any land. In contrast, the Ohio Company had a genuine plan of settlement.

O-Acetylpsilocin (psilacetin) and several other esters of psilocin were patented on January 16, 1963 by Sandoz Ltd via Albert Hofmann & Franz Troxler. Despite this, psilacetin remains a psychedelic compound with a limited history of use. It is theorized to be a prodrug of psilocin, as is psilocybin, which occurs naturally in many species of hallucinogenic mushrooms. This is because the aromatic acetyl moiety on the 4th position of the indole ring system is subject to deacetylation in acidic conditions such as those found in the stomach.

There are several of groups that increase the potency of the compound, mostly amides, amines and tetrazoles but also methylsulfonyl and trifluoromethyl groups. Of these groups, carboxamide has the greatest binding and had similar clotting activity as the compounds. In dog testing, this compound with a carboxamide group called 13F, showed a great pharmacokinetical profile, a low clearance and adequate half-life and volume of distribution. Due to the success of finding a stabilizing group, SAR research for S1 binding moiety (p-methoxyphenyl) was discontinued.

In this paper they have also proposed a L-tryptophan as a source of the uracil-containing part of the molecule. Study of the biosynthesis of the sparsomycin in a greater detail has revealed that L-cysteine and S-methyl group of methionine are real precursors for the monooxo-dithioacetal group. These studies have also confirmed the L-tryptophan being a predecessor of the uracil moiety of the sparsomycin. However, it still remained unclear whether the transformation proceeds through the kynureine pathway or not.

Bachrach's illustration of , the dication of hexamethylbenzene Bachrach has written a textbook about computational organic chemistry, the second edition of which was published by John Wiley and Sons in 2014. Bachrach maintains a blog to provide supplementary materials for the textbook. For example, following the publication of the structure of the dication of hexamethylbenzene, , in Angewandte Chemie International Edition, Bachrach discussed its pyramidal geometry and six-coordinate carbon moiety in a blog post, demonstrating it is not hypervalent and explaining its three-dimensional aromaticity.

Indolyl-3-acryloylglycine, also known as trans-indolyl-3-acryloylglycine, or IAG for short, is a compound consisting of an indole group attached to an acrylic acid moiety, which is in turn attached to a glycine molecule. This compound has been shown to isomerize when exposed to light. It is likely a metabolic intermediate in the biosynthesis of tryptophan, and is synthesized from tryptophan via indolepropionic acid and indoleacrylicacid (IAcrA). It is also likely that IAcrA is converted into IAG in the gut wall.

Another approach to coating is ALD which coats the substrate layer-by-layer with atomic precision. The precision is because reactions are confined to the surface containing an active chemical moiety that reacts with a precursor; this limits thickness to one monolayer. This self-limiting growth is essential for complete coatings since deposition does not inhibit the access by other polymeric units to non-coated sites. Thicker samples can be produced by cycling gases in a similar manner to alternating with oppositely charged polymers in LbL.

Ethyl group (highlighted blue) as part of a molecule, as the ethyl radical, and in the compounds ethanol, bromoethane, ethyl acetate, and ethyl methyl ether. In chemistry, an ethyl group is an alkyl substituent derived from ethane (C2H6). It has the formula -CH2CH3 and is very often abbreviated Et. Ethyl is used in the IUPAC nomenclature of organic chemistry for a saturated two-carbon moiety in a molecule, while the prefix "eth-" is used to indicate the presence of two carbon atoms in the molecule.

As a result, Cyan added more characters to the sequel, Riven. Villagers scurry away as the player approaches, and major characters such as Gehn and a rebel band known as the Moiety address the player and give or take items away from him or her. For the first time, Cyan directed the live action actors for Rivens scenes; the designers, including Richard Vander Wende, were apprehensive about how the characters would fit in the finished product. Rand Miller reprised the role of Atrus due to fan expectation, even though he hated acting.

68 Certain freehold and copyhold hereditaments and leasehold tenements of Henry Belward Ray were left in his will to infants with whom he – (the testator) – had no blood relation. To ensure that Ray's land would not escheat to the Crown, in March 1860, his trustees presented a petition to the Lord High Chancellor of Great Britain to create an Act of Parliament which would legally allow Arthur Lupton, Esq. of Potternewton Lodge undivided moiety, i.e. the rights of a mesne lord of the manor of Potternewton, and not the exclusive ownership of a lord paramount.

Cinnamic acid was confirmed to bind in a similar manner using inactive AnFdc1 crystals containing FMN. The AnFdc1 E282Q mutant crystallised with cinnamic acid revealed a structure corresponding to the Int2 species, this was taken to mean that progression through the 1,3-dipolarcycloadition cycle was halted as E282 is unable to donate a proton to the alkene moiety. In order to observe the Int1 and Int3 structures alkyne analogues were used. Like alkenes these compounds can also act as dipolarophiles but cycloaddition would yield a cycloadduct containing a double bond.

An inactive AnFdc1 enzyme (with prFMNradical bound) co-crystallised with the phenylpropiolic acid revealed binding in a similar manner to the α-fluorocinnamic acid AnFdc1 and cinnamic acid AnFdc1 with FMN bound (Inhib). An active AnFdc1 enzyme co-crystallised with phenylpropiolic acid revealed clear density for a 3-pyrroline cycloadduct (Int3’) between the alkyne and prFMNiminium. Int3’ represents a structure post decarboxylation, so it was assumed that over the time it took for crystallisation (~24h) the decarboxylation had occurred. Using a rapid soaking procedure, a different cycloadduct was observed that retained the carboxyl moiety (Int1’).

Melibiose is a reducing disaccharide formed by an α-1,6 linkage between galactose and glucose (D-Gal-α(1→6)-D-Glc). It differs from lactose in the chirality of the carbon where the galactose ring is closed and that the galactose is linked to a different point on the glucose moiety. It can be formed by invertase-mediated hydrolysis of raffinose, which produces melibiose and fructose. Melibiose can be broken down into its component saccharides, glucose and galactose, by the enzyme alpha-galactosidase, such as MEL1 from Saccharomyces pastorianus (lager yeast).

Rocaʻs father was the Emperor Cápac Yupanqui, whose heir apparent (by his wife Cusi Hilpay) had been his son Quispe Yupanqui. However, after Cápac Yupanquiʻs death, the hanan moiety rebelled against the hurin, killed Quispe Yupanqui, and gave the throne to Inca Roca, son of another of Cápac Yupanquiʻs wives, Cusi Chimbo. Inca Roca moved his palace into the hurin section of Cuzco. In legend, he is said to have conquered the ChancasDick Edgar Ibarra Grasso (1963) "Novedades Sobre la Verdadera Historia de los Incas" Journal of Inter- American Studies 5(1): pp.

The kinship systems observed by many communities included a division into moieties, with restrictions on intermarrying dictated by the moiety an individual belonged to.Berndt, R.M & C.H. The World of the First Australians; Aboriginal traditional life, past and present" (Aboriginal Studies Press, Canberra). Describing prehistoric Aboriginal culture and society during her 1999 Boyer Lecture, Australian historian and anthropologist Inga Clendinnen explained: > "They [...] developed steepling thought-structures – intellectual edifices > so comprehensive that every creature and plant had its place within it. They > travelled light, but they were walking atlases, and walking encyclopedias of > natural history.

The first English land-holding by the family was the feudal barony of Bramber in Sussex, granted by King William the Conqueror to William I de Braose (died 1093/1096) between the Norman Conquest of 1066 and the Domesday Book of 1086 in which he is shown as the holder of Bramber. Philip I made personal conquests in the Welsh Marches of Radnor and Builth. A moiety of the feudal barony of Barnstaple was inherited by William II from his mother. William III acquired the feudal barony of Kington c.

1194 and the lordship of Gower in 1203, and a moiety of the feudal barony of Totnes in 1206. King John temporarily seized most of the lands of William III in 1208 but his infant son King Henry III (1216–1272) regranted most, except Barnstaple which was lost permanently, to his 3rd son Reginald. Reginald's son William V died leaving 4 daughters co-heiresses to all the family's Welsh lands, but Bramber and Gower passed back to the senior family line which held them until 1326 when William VII died leaving two daughters co-heiresses.

The tert- butyl functional group is a unique moiety in this compound: two of the three carbons were found to originate from the amino acid valine, which contains an isopropyl alkyl side chain. This was determined by deuteration of valine supplied in the media, where mass spectroscopy identified mass/charge ratio reflecting the replacement of 8 hydrogens with deuterium in valine. The final alkyl group in the tert-butyl group was found to be from methionine, likely from S-adenylation. The order in which these precursor units are synthesized has not been confirmed.

Esters of estradiol like estradiol undecylate are readily hydrolyzed prodrugs of estradiol, but have an extended duration when administered in oil via intramuscular injection due to a depot effect afforded by their fatty acid ester moiety. As prodrugs of estradiol, estradiol undecylate and other estradiol esters are estrogens. Estradiol undecylate is of about 62% higher molecular weight than estradiol due to the presence of its C17β undecylate ester. Because estradiol undecylate is a prodrug of estradiol, it is considered to be a natural and bioidentical form of estrogen.

Patients also don't have appropriate DNA repair, and they also have increased genomic instability. In normal conditions, the LMNA gene codes for a structural protein called prelamin A, which undergoes a series of processing steps before attaining its final form, called lamin A.LMNA Genes Genetics Home Reference Prelamin A contains a “CAAX”where C is a cysteine, an aliphatic amino acid, and X any amino acid. This motif at the carboxyl-termini of proteins triggers three sequential enzymatic modifications. First, protein farnesyltransferase catalyzes the addition of a farnesyl moiety to the cysteine.

Human gamma- glutamyltransferase catalyzes the transfer of the glutamyl moiety of glutathione to a variety of amino acids and dipeptide acceptors. This heteroduplex enzyme is composed of a heavy chain and a light chain, which are derived from a single precursor protein, and is present in tissues involved in absorption and secretion. This enzyme is a member of the gamma- glutamyltransferase protein family, of which many members have not yet been fully characterized. This gene encodes several transcript variants; studies suggest that many transcripts of this gene family may be non-functional or represent pseudogenes.

The onium heads are usually kept small and the chains connecting the heads usually keep the N-N distance at 10 N or O atoms. Keeping the distance in mind the structure of the chain can vary (double bonded, cyclohexyl, benzyl, etc.) Succinylcholine has a 10-atom distance between its N atoms, like decamethonium. Yet it has been reported that it takes two molecules, as with acetylcholine, to open one nicotinic ion channel. The conformational explanation for this is that each acetylcholine moiety of succinylcholine prefers the gauche (bent, cis) state.

Two functional groups contribute significantly to aminosteroidal neuromuscular blocking potency, it is presumed to enable them to bind the receptor at two points. A bis-quaternary two point arrangement on A and D-ring (binding inter-site) or a D-ring acetylcholine moiety (binding at two points intra-site) are most likely to succeed. A third group can have variable effects. The quaternary and acetyl groups on the A and D ring of pipecuronium prevent it from binding intra-site (binding to two points at the same site).

Pyoluteorin is synthesized from an NRPS/PKS hybrid pathway. The resorcinol ring is derived from a type I PKS while the dichloropyrrole moiety is derived from a type II NRPS. Pyoluteorin biosynthesis begins with the activation of L-proline to prolyl-AMP by the adenylation domain PltF. With prolyl-AMP still in the active site, the active form of the peptidyl carrier protein PltL binds to PltF. Then PltF catalyzes the aminoacylation of PltL by attaching L-proline to the thiol of the 4’phosphopantetheine arm of PltL.

Sulfasalazine has been a major agent in the therapy of mild to moderate ulcerative colitis for over 50 years. In 1977, it was shown that 5-aminosalicylic acid (5-ASA, mesalazine/mesalamine) was the therapeutically active component in sulfasalazine. Many 5-ASA drugs have been developed with the aim of delivering the active compound to the large intestine to maintain therapeutic efficacy but with reduction of the side effects associated with the sulfapyridine moiety in sulfasalazine. Oral 5-ASA drugs are particularly effective in inducing and in maintaining remission in mild to moderate ulcerative colitis.

Site of Bullington Priory Bullington Priory was a priory in Bullington, Lincolnshire, England. The priory was a house of the Gilbertine Order and dedicated to Saint Mary. It was founded as a double house between 1148 and 1154 by Simon, son of William de Kyme, who gave part of his park for the site, along with wood and land, the churches of Bullington and Langton, and Hackthorn Mill. His son, Philip de Kyme, provided for seven canons with land in Faldingworth, the churches of Spridlington and Winthorpe, and a moiety of Friskney.

Richard Duke (died 1716), son and heir, who married Frances Southcott, daughter of George Southcote of Buckland-Tout- Saints. In an apparent effort to facilitate the re-election of his son as its MP, in 1681 he purchased a moiety of the manor and borough of Ashburton "at the commanding persuasion" of Sir William Courtenay, 1st Baronet, of Powderham, from Hon. Lewis Watson (1655–1724), MP.Ferris, John. P., Biography of Duke, Richard (1652–1733), of Otterton, Devon, Published in The History of Parliament: the House of Commons 1660–1690, ed.

Property, contractual, business entities structure, much of civil procedure, and family law are still strongly influenced by traditional Roman legal thinking. Louisiana law retains terms and concepts unique in American law: usufruct, forced heirship, redhibition, and lesion beyond moiety are a few examples. Due to the civil law tradition, Louisiana's constitution does not contain a right to a trial by jury in civil cases, although this right is contained in the Louisiana Revised Statutes. Additionally, appellate courts have a much broader discretion to review findings of fact by juries in civil cases.

The protein functions independent of the cell surface target or cell line, thus is most likely to recognize maytansine or a moiety within the maytansine scaffold.Through transmembrane transport activity, the protein regulates catabolite concentration in the lysosome. In addition, SLC46A3 expression has been identified as a mechanism for resistance to ADCs with noncleavable maytansinoid and pyrrolobenzodiazepine warheads. Although subcellular localization predictions have failed to identify the lysosome as a final destination of the protein, the YXXphi motif identified in the protein sequence has shown to direct lysosomal sorting.

Cation–π interactions have been observed in the crystals of synthetic molecules as well. For example, Aoki and coworkers compared the solid state structures of Indole-3-acetic acid choline ester and an uncharged analogue. In the charged species, an intramolecular cation–π interaction with the indole is observed, as well as an interaction with the indole moiety of the neighboring molecule in the lattice. In the crystal of the isosteric neutral compound the same folding is not observed and there are no interactions between the tert-butyl group and neighboring indoles.

A general acyl group (blue) in a ketone (top left), as an acylium cation (top centre), as an acyl radical (top right), an aldehyde (bottom left), ester (bottom centre) or amide (bottom right). (R1, R2, R3 = organyl substituent or hydrogen) An acyl group is a moiety derived by the removal of one or more hydroxyl groups from an oxoacid, including inorganic acids. It contains a double-bonded oxygen atom and an alkyl group (R-C=O). In organic chemistry, the acyl group (IUPAC name: alkanoyl) is usually derived from a carboxylic acid.

Mark Roberts is a Welsh businessman notable for the purchase of approximately sixty United Kingdom titles as Lord of the Manor or Marcher Lord and his legal claims to historical rights associated with them. In several cases he has attempted to profit from the claimed rights. After having some of his rights revoked by a change of law in 2005, and a ruling that Marcher Lords no longer exist in 2008, Roberts' only standing legal right is to a moiety of wreck off the coast of some areas of Wales.

Proline was chosen as the amino acid moiety because of its presence as the carboxy terminal amino acid residue in teprotide and other ACE inhibitors found in snake venoms. 11 other amino acids were tested but none of them were more inhibitory. So it was proposed that succinyl amino acid derivative should be an ACE inhibitor and succinyl-L- proline was found to be such an inhibitor. It was also known that the nature of penultimate amino acid residue of a peptide substrate for ACE influences binding to the enzyme.

Stercobilin results from breakdown of the heme moiety of hemoglobin found in erythrocytes. Macrophages break down senescent erythrocytes and break the heme down into biliverdin, which rapidly reduces to free bilirubin. Bilirubin binds tightly to plasma proteins (especially albumin) in the blood stream and is transported to the liver, where it is conjugated with one or two glucuronic acid residues into bilirubin diglucuronide, and secreted into the small intestine as bile. In the small intestine, some bilirubin glucuronide is converted back to bilirubin via bacterial enzymes in the terminal ileum.

A total asymmetric synthesis of salvinorin A, which relies on a transannular Michael reaction cascade to construct the ring system, was achieved as a 4.5% overall yield over 30 steps, then revised using 24 steps to yield salvinorin A in 0.15% yield. An approach to the trans-decalin ring system of salvinorin A used an intramolecular Diels-Alder reaction/Tsuji allylation strategy, and a total synthesis of salvinorin A was achieved using the intramolecular Diels-Alder / Tsuji allylation approach, combined with an asymmetric late-stage addition of the furan moiety.

Wode, probably the northern wooded portion of the peninsula, seems to have been a member of the manor of East Standen, and passed with it until the death of Nicholas Glamorgan about 1362–3. It then seems to have been divided, part going with Standen to the Bramshotts and Howles, and the rest with Wolverton to the Hakets and Gilberts. The former moiety is not mentioned after 1480; the latter apparently followed the same descent as Wolverton. The name is now lost, and the manor is apparently merged in Bembridge Farm.

34-37 The highest political and religious leader among the Qemant is their High Priest, called the Wember (also transliterated Womber and Wambar), an Amharic term meaning "seat." There were formerly two superior wambars, at Karkar and at Chelga, with the first being senior, and a varying number of subordinate wambars in other parts of Qemantland. All wambars are chosen from certain lineages in the Keber moiety. The last wambar of Karkar died in 1955, and since then the only wambar has been Mulunah Marsha, Wambar of Chelga (born 1935).

Preparing TNP-ATP is a one-step synthesis that is relatively safe and easy. Adenosine’s ribose moiety can be trinitrophenylated by 2,4,6-trinitrobenzene-1-sulfonate (TNBS). The resulting compound assumes a bright orange color and has visible absorption characteristics, as is characteristic of a Meiseinheimer spiro complex compound linking. To see the exact method of preparion, please refer to T. Hiratsuka's and K. Uchida's paper "Preparation and Properties of 2'(r 3')-O(2,4,6-trinitrophenyl) Adenosine 5'-triphosphate, an Analog of Adenosine Triphosphate," found in the reference section.

Gram-positive bacteria regulate autolysins with teichoic acid molecules attached to the tetrapeptide of the peptidoglycan matrix. The antibiotics complestatin and corbomycin prevent autolysin from remodeling the cell wall by binding to peptidoglycan, therefore stopping bacterial growth. The amide linkages between stem peptide and lactyl moiety of muramoyl residue are cleaved by N-acetylmuramoyl-l-alanine amidases and partakes in cell separation and the dissociation of the cell septum. There are 5 types of autolysins that contribute to cell separation of daughter cells, LytC, LytD, LytE, and LytF.

Patched is part of a negative feedback mechanism for hedgehog signaling that helps shape the spatial gradient of signaling activity across tissues. In the absence of hedgehog, low levels of patched are sufficient to suppress activity of the signal transduction pathway. When hedgehog is present, its cholesterol moiety binds to the sterol-sensing domain in patched, which then inhibits the activity of smoothened. Smoothened is a G protein-coupled receptor, most of which is stored in membrane bound vesicles internally within the cell and which increases at the cell surface when hedgehog is present.

Buspirone was originally classified as an azaspirodecanedione, shortened to azapirone or azaspirone due to the fact that its chemical structure contained this moiety, and other drugs with similar structures were labeled as such as well. However, despite all being called azapirones, not all of them actually contain the azapirodecanedione component, and most in fact do not or contain a variation of it. Additionally, many azapirones are also pyrimidinylpiperazines, though again this does not apply to them all. Drugs classed as azapirones can be identified by their -spirone or -pirone suffix.

It is a molecule constructed with a single FA moiety and extended by a hydrophilic peptide-based spacer that is, in turn, linked to Vinca alkaloid and mitomycin units via 2 distinct disulfide-containing linkers. Animals bearing well- established human tumor xenografts were found to completely respond to EC0225 therapy with dosing regimens that were approximately 3-fold less intensive to that required for EC145. A Phase 1 trial for EC0225 is in progress. BMS-753493 is a molecule born from a collaboration between scientists at Endocyte Inc.

The separation of the Aldford moiety into a district parish probably took place early in the 12th century when, at the time, Churton was also believed to have divided by a parish boundary along the lines of a manorial border. Until the early 20th century, the remains of steps of an ancient cross, which marked the boundaries of the manors of Aldford and Farndon, could still be seen. These steps were situated at the confluence of Pump Lane and the main road through the village. There is no trace of this boundary marker today.

15(S)-HETE is unambiguously designated by a shortened version of its IUPAC name viz., 15(S)-hydroxy-5Z,8Z,11Z,13E-eicosatetraenoic acid. In this terminology S refers to the absolute configuration of the chirality of the hydroxy functional group at carbon position 15. Its 15(R) enantiomer is designated 15(R)-hydroxy-5Z,8Z,11Z,13E-eicosatetraenoic acid. Z and E give the cis–trans isomerism about each double bond moiety at carbon positions 5, 8, 11, and 13 with Z indicating cis and E indicating trans isomerism.

He was also dismissed from the high stewardship of Stafford in February 1688. In December 1688, after the outbreak of the Glorious Revolution, Ferrers, Lord Chesterfield, and a retinue of gentlemen attended Princess Anne in Nottingham and escorted her to Warwick. Under William III and Mary II, Ferrers was re-appointed as high steward of Stafford. In 1692, Ferrers and Thynne (the latter now Viscount Weymouth) decided to partition the Barony of Farney in County Monaghan, both possessing an equal moiety of it as coheirs of Robert Devereux, 3rd Earl of Essex.

The general reaction catalyzed by a phosphatase enzyme Phosphatases catalyze the hydrolysis of a phosphomonoester, removing a phosphate moiety from the substrate. Water is split in the reaction, with the -OH group attaching to the phosphate ion, and the H+ protonating the hydroxyl group of the other product. The net result of the reaction is the destruction of a phosphomonoester and the creation of both a phosphate ion and a molecule with a free hydroxyl group. Phosphatases are able to dephosphorylate seemingly different sites on their substrates with great specificity.

As long as the fluorophore and the quencher are in proximity, quenching inhibits any fluorescence signals. TaqMan probes are designed such that they anneal within a DNA region amplified by a specific set of primers. (Unlike the diagram, the probe binds to single stranded DNA.) TaqMan probes can be conjugated to a minor groove binder (MGB) moiety, dihydrocyclopyrroloindole tripeptide (DPI3), in order to increase its binding affinity to the target sequence; MGB-conjugated probes have a higher melting temperature (Tm) due to increased stabilisation of van der Waals forces.

In dilute aqueous solution, such as is commonly used for Enhanced Oil Recovery applications, polyacrylamide polymers are susceptible to chemical, thermal, and mechanical degradation. Chemical degradation occurs when the labile amide moiety hydrolyzes at elevated temperature or pH, resulting in the evolution of ammonia and a remaining carboxyl group. Thus, the degree of anionicity of the molecule increases. Thermal degradation of the vinyl backbone can occur through several possible radical mechanisms, including the autooxidation of small amounts of iron and reactions between oxygen and residual impurities from polymerization at elevated temperature.

The high resolution crystal structure of the α-subunit of the glutaconyl-CoA decarboxylase (Gcdα) of Acidaminococcus fermentans (TC# 3.B.1.1.3) has been solved (). The active site of the dimeric enzyme lies at the interface between the two monomers. The N-terminal domain binds the glutaconyl-CoA, and the C-terminal domain binds the biotinyl lysine moiety. The enzyme transfers CO2 from glutaconyl-CoA to a biotin carrier protein (the γ-subunit) that is subsequently decarboxylated by the carboxybiotin decarboxylation site within the Na+ pumping beta subunit (Gcdβ).

In the field of drug discovery, retrometabolic drug design is a strategy for the design of safer drugs either using predictable metabolism to an inactive moiety or using targeted drug delivery approaches. The phrase retrometabolic drug design was coined by Nicholas Bodor. The method is analogous to retrosynthetic analysis where the synthesis of a target molecule is planned backwards. In retrometabolic drug design, metabolic reaction information of drugs is used to design parent drugs whose metabolism and distribution can be controlled to target and eliminate the drug to increase efficacy and minimize undesirable side effects.

Acyloxyacyl hydrolase (AOAH) is a lipase that selectively releases the secondary (acyloxyacyl-linked) fatty acyl chains from the hexaacyl lipid A moiety found in many bacterial lipopolysaccharides (LPSs, also called endotoxins). The resulting tetraacyl LPS is non-stimulatory and can be a potent inhibitor of LPS sensing via the MD-2--Toll-like Receptor 4 (TLR4). The enzyme's 2 disulfide-linked subunits are encoded by a single mRNA. The smaller subunit is a member of the saposin- like (SAPLIP) protein family and the larger subunit, which contains the active site serine, is a GDSL lipase.

Borrelidin is an 18-membered polyketide macrolide derived from several Streptomyces species. First discovered in 1949 from Streptomyces rochei, Borrelidin shows antibacterial activity by acting as an inhibitor of threonyl- tRNA synthetase and features a nitrile moiety, a unique functionality in natural products., Borrelidin also exhibits potent angiogenesis inhibition, which was shown in a rat aorta matrix model. Other studies have been performed to show that low concentrations of borrelidin can suppress growth and induce apoptosis in malignant acute lymphoblastic leukemia cells. Borredlidin’s antimalarial activity has also been shown in vitro and in vivo.

1497), son of the Duchess of Somerset, and step father of Margaret Beaufort who was mother of Henry VII. The bodies of Oliver St John and Elizabeth are buried beneath a black marble slab with brass inscriptions in the South Stoke church chancel. The South Stoke manor passed to Joan, the daughter of Henry Rochford, and through marriage and purchase to Stanhope, Skeffington, Ellys, Fountain, Heale and Harrison families. In 1637 Sir John Harrison passed by moiety the manor to his daughter Margaret (1627–1679), who married Edmund Turnor Esqu (1619–1707).

Joseph Outram was a promoter of the Cromford Canal, and when William Jessop was approached to design and build it he found an able assistant in 24-year-old Benjamin. Construction of the canal, particularly Butterley Tunnel, revealed substantial mineral deposits. The neighbouring Butterley Hall and its estate came on the market at this time and Francis Beresford, solicitor to the canal company, bought the freehold of the hall and its estate. He leased it on a moiety to Outram until the latter had acquired enough capital for a fifty percent holding.

Uridine is a glycosylated pyrimidine-analog containing uracil attached to a ribose ring (or more specifically, a ribofuranose) via a β-N1-glycosidic bond. It is one of the five standard nucleosides which make up nucleic acids, the others being adenosine, thymidine, cytidine and guanosine. The five nucleosides are commonly abbreviated to their one-letter codes U, A, T, C and G respectively. However, thymidine is more commonly written as 'dT' ('d' represents 'deoxy') as it contains a 2'-deoxyribofuranose moiety rather than the ribofuranose ring found in uridine.

In short, identity was not reducible to belonging to one or another segmentary division of a tribe, but involved far more concrete traits. Throughout the Australian totemic system he believed he could isolate a logic, which in its fullest form, evinced 8 combinations of three paired terms of primary properties. Two totems in a binary tribal moiety could be shown to each involve a set of up to 20 features that could be distributed as traits over all human and non-human members of each of the two groups.

This gene encodes a member of the hedgehog family. The hedgehog gene family encodes signaling molecules that play an important role in regulating morphogenesis. This protein is predicted to be made as a precursor that is autocatalytically cleaved; the N-terminal portion is soluble and contains the signalling activity while the C-terminal portion is involved in precursor processing. More importantly, the C-terminal product covalently attaches a cholesterol moiety to the N-terminal product, restricting the N-terminal product to the cell surface and preventing it from freely diffusing throughout the organism.

The occurrence of adverse drug reactions is common, owing to its narrow therapeutic index (the margin between effectiveness and toxicity). Gynaecomastia (enlargement of breast tissue) is mentioned in many textbooks as a side effect, thought to be due to the estrogen-like steroid moiety of the digoxin molecule, but when systematically sought, the evidence for this is equivocal . The combination of increased (atrial) arrhythmogenesis and inhibited atrioventricular (AV) conduction (for example paroxysmal atrial tachycardia with AV block – so-called "PAT with block") is said to be pathognomonic (that is, diagnostic) of digoxin toxicity.

One moiety part of the ancient office of Lord Great Chamberlain is a Cholmondeley inheritance. Notes and Queries (1883 January–June), p. 42. This hereditary honour came into the Cholmondeley family through the marriage of the first Marquess of Cholmondeley to Lady Georgiana Charlotte Bertie, daughter of Peregrine Bertie, 3rd Duke of Ancaster and Kesteven. Portcullis : Deed of Covenant and Agreement between Lord Willoughby de Eresby, The Dowager Marchioness of Cholmondeley and the Marquis of Cholmondeley re the exercise of the Office of Hereditary Great Chamberlain (16 May 1829).

One moiety part of the ancient office of Lord Great Chamberlain is a Cholmondeley inheritance. Notes and Queries (1883 Jan–Jun), p. 42. This hereditary honour came into the Cholmondeley family through the marriage of the first Marquess of Cholmondeley to Lady Georgiana Charlotte Bertie, daughter of Peregrine Bertie, 3rd Duke of Ancaster and Kesteven. Portcullis : Deed of Covenant and Agreement between Lord Willoughby de Eresby, The Dowager Marchioness of Cholmondeley and the Marquis of Cholmondeley re the exercise of the Office of Hereditary Great Chamberlain (16 May 1829).

2′-O-methyl-adenosine, a modified adenosine. 2′-O-methylation is a common nucleoside modification of RNA, where a methyl group is added to the 2′ hydroxyl of the ribose moiety of a nucleoside, producing a methoxy group. 2′-O-methylated nucleosides are mostly found in ribosomal RNA and small nuclear RNA and occur in the functionally essential regions of the ribosome and spliceosome. Currently, about 1210 2′-O-methylations (2′-O-Me) have been identified in mammals and yeast and deposited in RMBase (RNA Modification Base) database.

In 1839 and 1840, respectively, Henry and David's brothers Robert Smith Potts and Joseph Potts were brought into the partnership. Ultimately, David bought out most of the family interest, except for a moiety held by his nephew, William A. Smith. David's nephew Charles Follen McKim, later an architect, was born at Isabella in 1847. The furnace was well-run under David's direction, and in 1850, produced of iron per year. The furnace was converted to a forge in 1853. However, changing conditions in the iron market in the mid-1850s badly damaged David's financial position.

The Seal of Gilbert de Clare Gilbert de Clare, 4th Earl of Hertford, 5th Earl of Gloucester, 1st Lord of Glamorgan, 7th Lord of Clare (1180 - 25 October 1230) was the son of Richard de Clare, 3rd Earl of Hertford (c. 1153–1217), from whom he inherited the Clare estates. He also inherited from his mother, Amice Fitz William, the estates of Gloucester and the honour of St. Hilary, and from Rohese, an ancestor, the moiety of the Giffard estates. In June 1202, he was entrusted with the lands of Harfleur and Montrevillers.

Chemotactic range fitting Chemotactic responses elicited by the ligand-receptor interactions are, in general, distinguished upon the optimal effective concentration(s) of the ligand. Nevertheless, correlation of the amplitude elicited and ratio of the responder cells compared to the total number are also characteristic features of the chemotactic signaling. Investigations of ligand families (e.g., amino acids or oligo peptides) proved that there is a fitting of ranges (amplitudes; number of responder cells) and chemotactic activities: Chemoattractant moiety is accompanied by wide ranges, whereas chemorepellent character by narrow ranges.

When the ledgers were returned to Phelps Dodge they discovered that the underpayment was as little as $1664.68. The reason for this discrepancy had been the difference of the value of the goods declared in Liverpool and the eventual market value in America, which had fallen. The apparent injustice of the fine against Phelps Dodge, one of the most respected merchant firms in America, became a public scandal. William E. Dodge appeared before the House of Representative’s Ways and Means Committee in Washington in 1874 when they investigate the Moiety system.

In the initial synthesis, cycloparaphenylenes with n = 9, 12, and 18 have been synthesized starting from macrocycles containing 1,4-syn-dimethoxy-2,5-cyclohexadiene units as masked aromatic rings. Lithium–halogen exchange with p-diiodobenzene followed by a two-fold nucleophilic addition reaction with 1,4-benzoquinone yielded a syn- cyclohexadiene moiety. Borylation of this material followed macrocyclization under Suzuki–Miyuara cross-coupling with an equivalent of the diiodide produced macrocycles in low yields which could be separated by column chromatography. These macrocycles were then reductively aromatized using sodium naphthalenide to yield [n]cycloparaphenylenes.

On the death of Edward Bruning, aged 98, in 1707 the manor changed hands several times until in 1761 the Rev. Richard Harris (great-grandson of Warden Harris), Vicar of Wymering and Rector of Wydley, bought a moiety of the manor from Sir Edward Worsley, and in 1768 the rest of the manor from William Smith. The Rev. Richard Harris died without issue and intestate in 1768, and the manor went to his nephew and heir at law, Lovelace Bigg, who in 1783 added to the property by purchase from Lord Dormer.

However, this relationship was reversed when the R3 group was NHSO2CH3, where the binding affinity of sulfone was 3-fold higher than that of sulfide. These results indicate that substituents of the B-ring largely determine the effect of the X-linkage in AR binding. Researchers have proposed that the tertiary hydroxyl group is involved in direct interaction with AR because when an acetyl group is introduced to that hydroxyl moiety, the receptor binding affinity greatly decreases. Nilutamide has very low affinity for AR when tested on castrated rat prostate.

Inhibition in live cells supports a critical role for PAK in PDGF-stimulated ERK activation. Reversible covalent binding of IPA-3 to the PAK1 regulatory domain prevents GTPase docking and the subsequent switch to a catalytically active state. PAK1 knockdown in prostate cancer cells is associated with reduced motility, reduced MMP9 secretion and increased TGFβ expression, which in these cases, is growth inhibitory. However, IPA-3's pharmacokinetic properties as well as undesirable redox effects in cells, due to the continuous reduction of the sulfhydryl moiety, make it unsuitable for clinical development.

Salvarsan has long been assumed to have an As=As double bond, akin to the N=N linkage in azobenzene. However, in 2005, in an extensive mass spectrometric analysis led by Professor Brian Nicholson of the University of Waikato, the arsenic-arsenic bonds in Salvarsan were shown to be single bonds rather than double bonds. Presumed to consist of RAs=AsR molecules, i.e. (RAs)2, Salvarsan was found to actually contain a mixture of cyclo-(RAs)3 and cyclo-(RAs)5 species, where R is the 3-amino-4-hydroxyphenyl moiety.

One moiety part of the ancient office of Lord Great Chamberlain is a Cholmondeley inheritance. Notes and Queries (1883 Jan–Jun), p. 42. This hereditary honour came into the Cholmondeley family through the marriage of the first Marquess of Cholmondeley to Lady Georgiana Charlotte Bertie, daughter of Peregrine Bertie, 3rd Duke of Ancaster and Kesteven. Portcullis : Deed of Covenant and Agreement between Lord Willoughby de Eresby, The Dowager Marchioness of Cholmondeley and the Marquis of Cholmondeley re the exercise of the Office of Hereditary Great Chamberlain (16 May 1829).

The combination of α-ionone and β-ionone is characteristic of the scent of violets and used with other components in perfumery and flavouring to recreate their scent. The carotenes α-carotene, β-carotene, γ-carotene, and the xanthophyll β-cryptoxanthin, can all be metabolized to β-ionone, and thus have vitamin A activity because they can be converted by plant-eating animals to retinol and retinal. Carotenoids that do not contain the β-ionone moiety cannot be converted to retinol, and thus have no vitamin A activity.

One moiety part of the ancient office of Lord Great Chamberlain is a Cholmondeley inheritance. Notes and Queries (1883 Jan–Jun), p. 42. This hereditary honour came into the Cholmondeley family through the marriage of the first Marquess of Cholmondeley to Lady Georgiana Charlotte Bertie, daughter of Peregrine Bertie, 3rd Duke of Ancaster and Kesteven. Portcullis: Deed of Covenant and Agreement between Lord Willoughby de Eresby, The Dowager Marchioness of Cholmondeley and the Marquis of Cholmondeley re the exercise of the Office of Hereditary Great Chamberlain (16 May 1829).

However, in 1456 the bishop confirmed Sir William Dethick's right to "the first licence to elect or provide a superior when the priory was vacant". In 1402 William Dethick, son of Cecilia Curzon, donated a moiety of the rectory of Mugginton to Breadsall. Dethick had, however, failed to follow proper procedure to alienate the lands; thus, upon his death, his "executors and trustees" were "heavily fined" by the crown. In 1444, Breadsall priory was sued by the Collegiate Church of St Mary in Leicester, over the tithes of a field called "Hethfield", near Mugginton.

The crystal structure complex with platensimycin employed a C163Q mutant, which gave a 50-fold increase in apparent binding. The Gln163 residue lies adjacent to the carboxylate of platensimycin but makes no specific hydrogen bond. The close proximity of the carboxylate of platensimycin (presumed to be an anion) to the anionic thiol of Cys163 in the wild type enzyme may suggest the reason behind the increase in binding of the C163Q mutant. The second set of residues worth considering comprises His303 and His340, which play a role in the decarboxylation mechanism of the malonyl moiety.

General reaction that is catalyzed by kinasesKinases mediate the transfer of a phosphate moiety from a high energy molecule (such as ATP) to their substrate molecule, as seen in the figure below. Kinases are needed to stabilize this reaction because the phosphoanhydride bond contains a high level of energy. Kinases properly orient their substrate and the phosphoryl group within their active sites, which increases the rate of the reaction. Additionally, they commonly use positively charged amino acid residues, which electrostatically stabilize the transition state by interacting with the negatively charged phosphate groups.

Nucleotide-binding oligomerization domain-containing protein 1 (NOD1) is a protein receptor that in humans is encoded by the NOD1 gene. It recognizes bacterial molecules and stimulates an immune reaction .. NOD1 protein contains a caspase recruitment domain (CARD). NOD1 is a member of NOD-like receptor protein family and is a close relative of NOD2. NOD1 is an intracellular pattern recognition receptor, which is similar in structure to resistant proteins of plants, and mediates innate and acquired immunity by recognizing molecules containing D-glutamyl-meso-diaminopimelic acid (iE-DAP) moiety, including bacterial peptidoglycan.

An PFOR reaction starts with the nucleophilic attack of C2 of TPP on the 2-oxo carbon of pyruvate, which forms a lactyl-TPP adduct. Next, the lactyl-TPP adduct releases the CO2 moiety, forming an anionic intermediate, which then transfer an electron to a [4Fe-4S] cluster. These steps lead to a stable radical intermediate that can be observed by electron paramagnetic resonance (EPR) experiments. The radical intermediate reacts with a CoA molecule, transfers another electron from the radical intermediate to a [4Fe-4S] cluster and forms an acetyl-CoA product.

High affinity FAD and iron binding sites and a single b-type heme binding site is present in the Steap3 transmembrane domain. Steap3 is functional as a homodimer and utilizes an intrasubunit electron transfer pathway through the single heme moiety rather than an intersubunit electron pathway through a potential domain-swapped dimer. The sequence motifs in the transmembrane domain that are associated with the FAD and metal binding sites are not only present in Steap2 and Steap4 but also in Steap1 which lacks the N-terminal oxidoreductase domain, suggesting that Steap1 harbors latent oxidoreductase activity.

Albert Grelley the younger in the time of Henry II gave one moiety to Alexander son of Uvieth at a rent of ½ mark and a hawk or 12d.Lancs. Inq. and Extents (Rec. Soc. Lancs, and Ches.), i, 57; The tenant's name is not recorded in 1212 but in 1227 Adam de Radcliffe was required to perform suit at Robert Grelley's court in Manchester fortnightly instead of monthly. A little earlier Eugenia, widow of William de Radcliffe, demanded from the same Adam de Radcliffe, her dower of four oxgangs in Little Lever.Inq.

The presence of an aromatic ring, a ketone and a γ-lactam moiety, gives to isatin the rare potential to be used as both an electrophile and a nucleophile: indeed, it undergoes an enormous number of reactions, such as N-substitutions, electrophilic aromatic substitution at positions C-5 and C-7 of the phenyl ring, nucleophilic additions onto the C-3 carbonyl group, chemoselective reductions, oxidations, ring-expansions and spiro-annulations. Because of this unique reactivity, isatin is considered one of the most valuable building blocks in organic synthesis.

Organothiophosphates are a subclass of organophosphorus compounds that are structurally related to the inorganic thiophosphates. Common members have formulas of the type (RO)3−xRxPS and related compounds where RO is replaced by RS. Many of these compounds are used as insecticides, some have medical applications, and some have been used as oil additives.J. Svara, N. Weferling, T. Hofmann "Phosphorus Compounds, Organic" in Ullmann's Encyclopedia of Industrial Chemistry, Wiley-VCH, Weinheim, 2006. Oligonucleotide phosphorothioates (OPS) are modified oligonucleotides where one of the oxygen atoms in the phosphate moiety is replaced by sulfur.

On dying, a Koamu is met on passing into the spirit world by his yuri or totem, who then reintroduces him to all of his relations, the natural species belonging to his moiety. The first bee was fashioned by a bat, which gummed on some cockatoo feathers to a sticky milky weed, which immediately took wing, and flew right down to Koamu territory, with the bat in hot pursuit, until it won sanctuary in a cave called Ungwari. The Koamu undertook rituals in this cavern to secure the increase of bees in their area.

The 4-carboxy-derivative EXP-6155 had a binding activity which was ten-fold greater than that of S-8308 which further strengthened this hypothesis. By replacing the 4-carboxy-group with a 2-carboxy-benzamido-moiety the compound EXP-6803 was synthesized. It had highly increased binding affinity but was only active when administered intravenously. Replacing the 2-carboxy- benzamido-group with a 2-carboxy-phenyl-group created the lipophilic biphenyl- containing EXP-7711, which exhibited good oral activity but slightly less affinity for the AT1 receptor.

Cystinosin is a seven- transmembrane domain receptor embedded in the lysosomal membrane, and is a member of the lysosomal cystine transporter family of transport proteins. It comprises 367 amino acid residues, and has a molecular mass of 41738 Da. Cystinosin has seven N-glycosylation sites in the N-terminus region, spanning a range of 128 amino acid residues. The receptor also has two sorting motifs; a GYDQL motif in the C-terminus region, and a YFPQA motif, known as the 'PQ loop,' on the fifth inter-transmembrane α-helix moiety.

Cofactor engineering has recently been successful in altering enzymes to prefer NADH as a cofactor instead of NADPH. In 2010, a group of scientists performed cofactor engineering on the enzyme Gre2p, an NADPH-preferring dehydrogenase found in Saccharomyces cerevisiae. Gre2p reduces the compound diketone 2,5-hexanedione into the chiral building blocks (5S)-hydroxy-2-hexanone and (2S,5S)-hexanediol. The scientists determined that Asn9 (Asparagine, position 9) was an important amino acid the active site of Gre2p. Specifically, Asn9 binds to the 3’-hydroxyl group and the 2’-oxygen atom of adenyl ribose moiety.

Many indole alkaloids formed from strictosidine synthase-catalyzed condensation are important precursors to medicinally important compounds such as quinine, the antineoplastic drug camptothecin, and anticancer drugs vincristine and vinblastine. Because of this, strictosidine synthase is widely known as the enzyme of choice for investigations towards chemoenzymatic alkaloid synthesis. One such investigation found (21S)-12-aza- nacycline, a 12-aza-strictosidine derivative, to exhibit potent cytotoxicity to the A549 cancer cell line. However, the enzyme possesses a high degree of substrate specificity, with the indole moiety of tryptamine required for substrate recognition.

The substrate hemithioacetal is formed when a molecule of glutathione — probably in its reactive thiolate form — attacks the C1 carbonyl of methylglyoxal or a related compound, rendering that carbon tetravalent. This reaction occurs spontaneously in the cell, without the involvement of the enzyme. This hemithioacetal is then bound by the enzyme, which shifts a hydrogen from C1 to C2. The C2 carbonyl is reduced to a tetravalent alcohol form by the addition of two protons, whereas the C1 carbonyl is restored by losing a hydrogen while retaining its bond to the glutathione moiety.

Among these changes are reducing the quinoline ring, replacing the chlorine with fluorine, inserting an ether linkage in between the two aromatic rings instead of the double bound and adding an amide group for the sulfur. Replacement of the quinoline by benzothiazole, dichlorothienopyridines or alkyl-substituted thiazoles is possible but none of these is superior. 288x288px Zafirlukast is an indole derivative that satisfies the pharmacophore need for an ionizable moiety with a sulfonamide group. Numerous analogues have been organized; nonetheless, everyone of them resulted in diminishing antagonistic activity.

In the Hoveyda–Grubbs catalysts, the benzylidene ligands have a chelating ortho-isopropoxy group attached to the benzene rings. The ortho- isopropoxybenzylidene moiety is sometimes referred to as a Hoveyda chelate. The chelating oxygen atom replaces a phosphine ligand, which in the case of the 2nd generation catalyst, gives a completely phosphine-free structure. The 1st generation Hoveyda–Grubbs catalyst was reported in 1999 by Amir H. Hoveyda's group, and in the following year, the second-generation Hoveyda–Grubbs catalyst was described in nearly simultaneous publications by the Blechert and Hoveyda laboratories.

Barentu Oromo people are one of the two main moiety of the Oromo people in the Oromia Region of Ethiopia. Between the twelfth and fifteenth centuries, the Borana Oromo and Barentu Oromo people had differentiated from the confederation. The Barentu people thereafter expanded to the eastern regions now called Hararghe, Arsi, Wello, and northeastern Shawa. The Borana people, empowered by their Gadda political and military organization expanded in the other directions, regions now called western Shawa, Welega, Illubabor, Kaffa, Gamu Goffa, Sidamo and in the 16th-century into what is now northern Kenya regions.

Ubiquitin is a highly conserved nuclear and cytoplasmic protein that has a major role in targeting cellular proteins for degradation by the 26S proteosome. It is also involved in the maintenance of chromatin structure, the regulation of gene expression, and the stress response. Ubiquitin is synthesized as a precursor protein consisting of either polyubiquitin chains or a single ubiquitin moiety fused to an unrelated protein. This gene encodes a fusion protein consisting of ubiquitin at the N-terminus and ribosomal protein L40 at the C-terminus, a C-terminal extension protein (CEP).

The term glycerophospholipid signifies any derivative of glycerophosphoric acid that contains at least one O-acyl, or O-alkyl, or O-alk-1'-enyl residue attached to the glycerol moiety. The alcohol here is glycerol, to which two fatty acids and a phosphoric acid are attached as esters. The two fatty acid chains attached to the molecule of glycerol are nonpolar hence hydrophobic while the polar heads which mainly consists of the phosphate group attached to the third carbon of the glycerol molecule is hydrophilic. This dual characteristic leads to the amphipathic nature of glycerophospholipids.

The rhamnose moiety for mono- and di- rhamnolipids is derived from AlgC activity and the RmlABCD pathway, encoded on the rmlBCAD operon. AlgC produces sugar precursors directly for alginate and lipopolysaccharide (LPS) as well as rhamnolipids. In rhamnose synthesis, AlgC produces glucose-1-phosphate (G1P) which is converted to dTDP-D-glucose by RmlA followed by conversion to dTDP-6-deoxy-D-4-hexulose and then dTDP-6-deoxy-L-lyxo-4-hexulose by RmlB and RmlC respectively. Finally, dTDP-6-deoxy-L-lyxo-4-hexulose is converted to dTDP-L-rhamnose by RmlD.

Celecoxib contains a sulfonamide moiety and may cause allergic reactions in those allergic to other sulfonamide-containing drugs. This is in addition to the contraindication in people with severe allergies to other NSAIDs. However, it has a low (reportedly 4%) chance of inducing cutaneous reactions among persons who have a history of such reactions to aspirin or nonselective NSAIDs. NSAIDs may cause serious skin adverse events, including exfoliative dermatitis, Stevens-Johnson syndrome, and toxic epidermal necrolysis; events may occur without warning and in patients without prior known sulfa allergy.

The amphiphilic nature of the moenomycins induce hemolytic activity, provide a long half-life in the blood stream, and creates a tendency to aggregate in aqueous solution. Comparison of moenomycins with an abridged isoprene chain of 10-carbons, show that the oligosaccharide can still tightly bind the enzyme active site, but in vivo the MIC significantly increases since the drug is unable to anchor itself to the cytoplasmic membrane and present its sugar moiety. Further studies are needed to determine the optimal length for favorable pharmacokinetic properties.Anikin, A., et al.

CuracinA Cyclopropyl Moiety Biosynthesis The CurB (ACP), CurC (ketosynthase), and CurD (HMG-CoA reductase) are responsible for the formation of (S)HMG-ACP3. HaI, from the CurA gene, is a unique non- heme halogenase that goes through a purported Fe(IV)=O intermediate to add a chlorine atom onto an unactivated carbon atom. After chlorination, ECH1 acting as a dehydratates HMG-ACP3 to 3-methylgultaconyl-ACP3 and ECH2 performs the required decarboxylation. Finally,an unusual ER catalyzed cyclization reaction, purported to go through a substitution like mechanism, forms the cyclopropane ring.

A particular RAFT agent is only suitable for a limited set of monomers and the synthesis of a RAFT agent typically requires a multistep synthetic procedure and subsequent purification. RAFT agents can be unstable over long time periods, are highly colored and can have a pungent odor due to gradual decomposition of the dithioester moiety to yield small sulfur compounds. The presence of sulfur and color in the resulting polymer may also be undesirable for some applications; however, this can, to an extent, be eliminated with further chemical and physical purification steps.

He was the son and heir of William de Botreaux (d. 22 July 1349) of Forrabury, Cornwall (renamed after his family Boscastle, anciently “Bottreaux Castle”, ) Sheriff of Cornwall, by Isabel de Moels, younger daughter and co-heiress (with her sister Muriel, the wife of Thomas Courtenay (d. 1363) 5th son of Hugh de Courtenay, 1st Earl of Devon) of John de Moels, 4th Baron Moels(d.1337), of East Berkhampstead, Hertfordshire and feudal baron of a moiety of North Cadbury, Somerset, by his wife Joan Lovel, daughter of Richard Lovel of Castle Cary, Somerset.

The totem pole was initially carved around the year 1790 and belonged to the Kinninook family, a Tlingit clan of the Raven moiety. It was carved to honor Chief-of- All-Women, a Tlingit woman who drowned in the Nass River while traveling to visit an ill sister. Her family hired a carver and gathered to tell him stories they wanted represented on her totem pole. When the totem pole was complete, they organized a potlatch and raised the totem pole in her honor in the Tlingit village on Tongass Island.

In most cases, the Gal residues terminate with α-L-arabinofuranose (Araf) residues. Some AGPs are rich in uronic acids (GlcA), resulting in a charged polysaccharide moiety, and others have short oligosaccharides of Araf. Specific sets of hydroxyproline O-β- galactosyltransferases, β-1,3-galactosyltransferases, β-1,6-galactosyltransferases, α-arabinosyltransferases, β-glucuronosyltransferases, α-rhamnosyltransferases, and α- fucosyltransferases are responsible for the synthesis of these complex structures. One of the features of type II AGs, particularly the (1,3)-linked β-D-Galp residues, is their ability to bind to the Yariv phenylglycosides.

Nitrosylation results in a molecule "R" adducted with the group N=O Nitrosylation is the general term for covalent incorporation of a nitric oxide "nitrosyl" moiety into another (usually organic) molecule. There are multiple chemical mechanisms by which this can be achieved; including biological enzymes and industrial processes. The biological functions of nitrosylation are particularly important as S-nitrosylation, the conjugation of NO to cysteine thiols in proteins, is an important part of cell signalling. Coordination of NO to transition metals to give metal nitrosyl complexes, is also referred to as nitrosylation.

Two years after his wife inherited the other portion of the estate, Robert le Helyon purchased a dwelling and further land from Valentine and Ellen de Chaldecote. All of this passed to his son Thomas in 1326, but within four years the land was owned by another son, Walter, suggesting that Thomas had died. In 1408 this moiety was held by John More and his wife Amice, and they granted a portion of it to John Fromond of Winchester College at the same time as Joan Woodlock's land was transferred to him.

Pyrrolidinone was the first R1 functional group to significantly increase the potency but further researches revealed even higher potency with a morpholinone group instead. Groups R2 and R3 had hydrogen or fluorine attached and it was quickly assessed that having hydrogen resulted in highest potency. Groups R2 and R3 were then substituted for various groups, which were all less potent than the hydrogen, so hydrogen was the final result. As the chlorothiophene moiety had an inadequate water solubility, substituting it with another group was attempted but was unsuccessful.

Electropolymerization supplies a thin polymer film, 10 to 100 nm. The electropolymerization of an insulating polymer results in self-limiting deposition as the active moiety is protected; the deposition can also be self-limiting if the polymer can block the solubilized monomer and prohibit continued growth. Through the control of electrochemical variables, polyaniline and polythiophene can be deposited in a controlled manner. Styrene, methyl methacrylate, phenols and other electrically insulating polymers have been deposited on the electrodes to act as a separator that allows ionic transport, but inhibits electrical transport to prevent shorts.

The high resolution crystal structure of the enzyme also reveals the presence of a binding pocket for the terminal phosphate of molybdopterin and suggests a possible binding site for the pterin moiety present both in precursor Z and molybdopterin. The structural similarity between ubiquitin and the small subunit of MPT synthase hints at the evolutionary relationship of the MoCo biosynthesis pathway and the ubiquitin dependent protein degradation pathway. Specifically, the small subunit MoaD in prokaryotes is a sequence homolog of Urm1, indicating that MPT synthase probably shares a common ancestor with ubiquitin.

Based on structural comparison, it appears that the enzyme utilizes a catalytic triad of residues Asp129, Glu153 and His297, with accessory residues His177 and Tyr239 coordinating the epoxide oxygen during ring opening. Cif is also the first example of an EH utilizing a His-Tyr pair to coordinate an epoxide substrate, rather than the canonical Tyr-Tyr pair. In the proposed enzyme mechanism, Asp129 nucleophilically attacks a carbon of the epoxide moiety of a substrate, forming an ester linked enzyme-acyl intermediate. The preference for which carbon is attacked varies depending upon the substrate.

Each subunit has three different structural domains: a short N-terminal epidermal growth factor (EGF) domain; an α-helical membrane-binding moiety; and a C-terminal catalytic domain. PTGS (COX, which can be confused with "cytochrome oxidase") enzymes are monotopic membrane proteins; the membrane-binding domain consists of a series of amphipathic α helices with several hydrophobic amino acids exposed to a membrane monolayer. PTGS1 (COX-1) and PTGS2 (COX-2) are bifunctional enzymes that carry out two consecutive chemical reactions in spatially distinct but mechanistically coupled active sites.

Digitoxigenin, the cardenolide substructure of cerberin, with the tetracyclic array of all-carbon steroid rings at its core, to which is attached the butenolide-type, oxygen-containing lactone substituent. Cerberin, like all cardiac glycosides, has as its core a steroid-type set of four carbocycles (all-carbon rings). In cerberin, this steroid core is connected, first, to a separate oxygen-containing lactone ring (shown here, upper right of box), and second, to a sugar substituent (shown in infobox structure, left of image). There are two types of cardiac glycosides depending on the characteristics of the lactone moiety.

ADP-ribose is an intermediate that is produced during the metabolism of NAD+, mono- or poly- unsaturated proteins, and cyclic-ADP ribose. ADP-ribose is a protein-glycating agent, and excess levels of ADP-ribose in the cell can cause non-enzymatic ADP-ribosylation. Non-enzymatic ADP-ribosylation can inactivate protein targets that contain nucleotide-binding sites when the adenylate moiety of ADP-ribose binds to them, and it can also interfere with metabolic regulation that occurs via enzymatic ADP-ribosylation. For example, actin polymerization is inhibited by non-enzymatic ADP-ribosylation at a Cys residue.

Catalysed dimerisation of acetone via an aldol condensation is well known, and yields diacetone alcohol and (by dehydration) mesityl oxide in both acidic and basic conditions. The in situ generation of mesityl oxide adds another reactive olefin to the mixture. In cases where an olefinic moiety can interact with a phenolic hydroxyl group (typically as a result of ortho-substitution), rapid cyclisation reactions producing flavans and chromans occur. This is the source of Dianin's compound in the mixture, and Dianin subsequently demonstrated that the compound can be produced in much greater yield by reacting phenol with mesityl oxide directly.

A simplified Jablonski diagram illustrating the change of energy levels. The principle behind fluorescence is that the fluorescent moiety contains electrons which can absorb a photon and briefly enter an excited state before either dispersing the energy non-radiatively or emitting it as a photon, but with a lower energy, i.e., at a longer wavelength (wavelength and energy are inversely proportional).Animation for the principle of fluorescence and UV-visible absorbance The difference in the excitation and emission wavelengths is called the Stokes shift, and the time that an excited electron takes to emit the photon is called a lifetime.

The Vikings and Anglo- Saxons seem to have co-existed peacefully with some Anglo-Saxon and Viking place names later being joined together—such as Bispham-with-Norbreck. Bispham having the Anglo-Saxon place name ham and Norbreck having the Viking place name, breck. Bispham-with-Norbreck comprised three hamlets – Great (or Greater) Bispham, Little Bispham and Norbreck, with Anchorsholme (then Angersholme) part of Norbreck. Although the three hamlets were originally part of the Lordship of Amounderness, they were later divided with the moiety of Little Bispham and Norbreck being given to Shrewsbury Abbey and Great Bispham to the Lord of Warrington.

In molecular biology, glycoside hydrolase family 92 is a family of glycoside hydrolases. Glycoside hydrolases are a widespread group of enzymes that hydrolyse the glycosidic bond between two or more carbohydrates, or between a carbohydrate and a non-carbohydrate moiety. A classification system for glycoside hydrolases, based on sequence similarity, has led to the definition of >100 different families. This classification is available on the CAZy web site, and also discussed at CAZypedia, an online encyclopedia of carbohydrate active enzymes. This domain occurs within alpha-1,2-mannosidases, which remove alpha-1,2-linked mannose residues from Man(9)(GlcNAc)(2) by hydrolysis.

25, 20 & 21 March 1558/9. In 1588 Dorothy Lewknor, widow of Edward Lewknor, subscribed to the loan raised by Queen Elizabeth at the time of the expected invasion by the Spanish Armada. She made her will as of Kingston Buci on 1 October 1587, making her son Edward her executor, and granting to her son Thomas her moiety of lands and tenements in Old Shoreham, and her term remaining in the manor of King's Barns. She refers to an indenture or recognizance made between herself and her Sir Francis Walsingham and Sir Henry Cocke in 1570.

A biological survey was conducted in the area in 1982 and researchers found 189 plant species, 53 species of bird, 19 reptile species and 9 species of mammal. Several of the birds are endangered including the flock bronzewing pigeon, red-chested button-quail, Australian bustard and the pictorella mannikin. The traditional owners of the lands are the Wambaya people, and it is part of the larger area of Rumburriya semi-moiety land known as Mangurinji. The area is significant to the Wambaya as ancestral beings known as Mangaya that feature in the dreamtime created several features in the area.

This dispute, which ran for over nine years, involved the interpretation of that very unsatisfactory testamentary device called a moiety. At one stage the dispute involved four years of expensive litigation in the Chancery court with the Attorney General and the Solicitor General acting for opposing sides and was not finally settled until 1778. In that year Sir Nicholas leased his own copper mine to a London banker John Dawes (a secret associate of Williams) for 21 years. Williams emerged from the dispute as the managing partner with the Revd Edward Hughes and John Dawes in the Parys Mine Company.

Furthermore, it has been shown to be safe for use, and with no severe adverse effects. Aramchol was initially intended to combine a cholesterol solubilizing moiety (a saturated fatty acid) with a bile acid (cholic acid) acting as a vehicle to enable secretion into bile and entry into the enterohepatic circulation to solubilise bile stones. However, early in the development, it was observed that Aramchol reduced liver fat infiltration in animals fed a high fat, lithogenic diet. This effect was confirmed in other animal models and the development plan was modified according to these findings, as fatty liver is an unmet need.

Amikacin evades attacks by all antibiotic- inactivating enzymes that are responsible for antibiotic resistance in bacteria, except for aminoacetyltransferase and nucleotidyltransferase. This is accomplished by the L-hydroxyaminobuteroyl amide (L-HABA) moiety attached to N-1 (compare to kanamycin, which simply has a hydrogen), which blocks the access and decreases the affinity of aminoglycoside-inactivating enzymes. Amikacin ends up with only one site where these enzymes can attack, while gentamicin and tobramycin have six. Bacteria that are resistant to streptomycin and capreomycin are still susceptible to amikacin; bacteria that are resistant to kanamycin have varying susceptibility to amikacin.

Utilizing different amounts of ancillary ligand, the researcher can toggle between a number of complex conformations. In the closed state, the metal center is fully chelated to both ligands. With the addition of one equivalent of the selected ancillary ligand, a semi-open complex is formed which involves one ligand fully chelated and the other bound to the metal only through the phosphorus moiety. In mixed ligand systems, the ancillary ligand will selectively displace the weakest Y–M bond - an important feature for the more sophisticated catalytic structures (based on the halide- induced ligand rearrangement (HILR) reaction and triple-layer geometries).

The N-terminal domain of tyrosyl-tRNA synthetase provides the chemical groups necessary for converting the substrates tyrosine and ATP into a reactive intermediate, tyrosyl-adenylate (the first step of the aminoacylation reaction) and for transferring the amino-acid moiety from tyrosyl-adenylate to the 3'OH-CCA terminus of the cognate tRNA(Tyr) (the second step of the aminoacylation reaction). The other domains are responsible (i) for the recognition of the anticodon bases of the cognate tRNA(Tyr); (ii) for the binding of the long variable arm of tRNA(Tyr) in eubacteria; and (iii) for unrelated functions such as cytokine activity.

In 1360, he was fighting in France in the campaign led by Edward III, who also knighted at Bourg-la-Reine. Thomas was in Prince Edward's Spanish campaign in 1367 and fought at the battle of Najera on 3 April 1367. During 1369, he was in Anjou and was captured by the French and was exchanged for Sire Caponnel de Caponnat, who was held by the English. During the same year, the Hamlet of Thorp was sold by the heirs of Thorp to Thomas, which became completely merged in his moiety of Bretherton, and ceased to be noticed.

The term dipolar bond is used in organic chemistry for compounds such as amine oxides for which the electronic structure can be described in terms of the basic amine donating two electrons to an oxygen atom. : → O The arrow → indicates that both electrons in the bond originate from the amine moiety. In a standard covalent bond each atom contributes one electron. Therefore, an alternative description is that the amine gives away one electron to the oxygen atom, which is then used, with the remaining unpaired electron on the nitrogen atom, to form a standard covalent bond.

Protein kinase GCN2 is a multidomain protein and its C-terminus contains a region homologous to histidyl-tRNA synthetase (HisRS) next to the kinase catalytic moiety. This HisRS-like region forms a dimer and dimerization is required for GCN2 function. The crucial contribution to GCN2 function is the promotion of tRNA binding and the stimulation of the kinase domain via physical interaction. Binding of uncharged tRNA to this synthetase-like domain induces a conformational change in which the GCN2 domains rotate 180° normal to the dimerization surface and thereby transpose from their antiparallel to a parallel orientation.

For a long time the overlordship of Upper Burgate (or "Over Burgate") seems to have belonged to the lord of the manor of Rockford. At the beginning of the 16th century, the 'manor' of Upper Burgate was in the possession of William Coke. In 1670 the manor was owned by Robert Blachford, who also owned a moiety of Sandhill Manor (Sandleheath), and in 1702 it was sold with Sandhill Manor to Thomas Warre. Some years later the manor seems to have been purchased by William and Jeremiah Cray and descended with Ibsley to Percival Lewis, to whom it belonged in 1810.

The chemical reaction can be written as: #UDP-N-acetyl-D- glucosamine + [protein]-L-serine → UDP + [protein]-3-O-(N-acetyl-D- glucosaminyl)-L-serine #UDP-N-acetyl-D-glucosamine + [protein]-L-threonine → UDP + [protein]-3-O-(N-acetyl-D-glucosaminyl)-L-threonine First, the hydroxyl group of serine is deprotonated by histidine 498, a catalytic base in this proposed reaction. Lysine 842 is also present to stabilize the UDP moiety. The oxygen ion then attacks the sugar-phosphate bond between the glucosamine and UDP. This results in the splitting of UDP-N-acetylglucosamine into N-acetylglucosamine – peptide and UDP.

A variety of oxygen-transport and -binding proteins exist in organisms throughout the animal and plant kingdoms. Organisms including bacteria, protozoans, and fungi all have hemoglobin-like proteins whose known and predicted roles include the reversible binding of gaseous ligands. Since many of these proteins contain globins and the heme moiety (iron in a flat porphyrin support), they are often called hemoglobins, even if their overall tertiary structure is very different from that of vertebrate hemoglobin. In particular, the distinction of "myoglobin" and hemoglobin in lower animals is often impossible, because some of these organisms do not contain muscles.

The Ishma controlled coastal the valleys of Rimac and Lurin rivers in modern-day Lima, from the mouth—sea of the rivers to the middle valley or "Chaupi Yunga" (middle Yunga altitude, between 500 and 1200 meters of elevation). Ishma territory reached up to the sanctuary of Mama located in Rimac (present-day Ricardo Palma) and the sites of Chontay and Sisicaya in Lurin at 1,000 meters above sea level.(Rostworowski, 1976, 1989; Espinoza, 1963, 1964, 1983). The Ishma were divided into two moiety administrative divisions or saya, these were the anan (upper) saya Ichma and luren (lower) saya Ichma.

1999, 121, 10219-10220 The phenolic oxygen of β-ICD was shown to be important in the reaction, implying the function of Bronsted acid moiety. β-ICD and its related versions are effective catalysts for various other substrates. 300px Cyclopentenone and various aromatic and aliphatic aldehydes undergo an asymmetric reaction using Fu's planar chiral DMAP catalyst in isopropanol (54-96% yield, 53-98% ee). In this case, magnesium iodide as a Lewis acid cocatalyst was required to accelerate the reaction.Chem. Commun. 2010, 46, 2644-2646 P-Chiral phosphines have been investigated. 250px Simple diamines can also be employed as MBH catalysts.

250px Chiral phosphine MBH catalysts often contain Bronsted acid moiety in their backbones. For example, chiral phosphines containing a Lewis base, a Bronsted acid, and an acid-activated Bronsted base were developed for an asymmetric aza-MBH reaction (86-96% yield, 79-92% ee). The Bronsted acid and base moieties were proposed to be involved in the stabilization of zwitterionic species in a stereoselective manner.Adv. Synth. Catal. 2009, 351, 331 350px BINOL-derived chiral phosphine catalyst is also effective for an asymmetric aza-MBH reaction of N-tosyl imines with activated alkenes such as methyl vinyl ketone and phenyl acrylate.Chem. Commun.

The 1st Viscount Weymouth died in 1714, without surviving male issue, and bequeathed his estates to his grand-nephew, also named Thomas Thynne, and ancestor of the Marquesses of Bath. Robert Shirley, 1st Earl Ferrers died in 1717, his estate, by agreement, devolving in equal parts to his four sons: Robert, George, Sewallis and John Shirley. Of these, only George survived and, as the others had died without issue, the whole estate passed to him. He was the grandfather of the Shirley brothers, Horatio Henry and Evelyn Philip, the 19th-century owners of the western moiety of Farney.

ADP-ribosylation is a common enzymatic method used by different bacterial toxins from various species. Toxins such as C. perfringens iota toxin and C. botulinum C2 toxin, attach a ribosyl-ADP moiety to surface arginine residue 177 of G-actin. This prevents G-actin assembling to form F-actin, and, thus, the cytoskeleton breaks down, resulting in cell death. Insecticidal members of the ADP-ribosyltransferase family of toxins include the Mtx1 toxin of Lysinibacillus sphaericus and the Vip1/Vip2 toxin of Bacillus thuringiensis and some members of the toxin complex (Tc) toxins from gram negative bacteria such as Photorhabdus and Xenorhabdus species.

Chronic, subclinical exposure does not lead to symptoms so dramatic as acute aflatoxicosis. Chronic exposure increases the risk of developing liver and gallbladder cancer, as aflatoxin metabolites may intercalate into DNA and alkylate the bases through epoxide moiety. This is thought to cause mutations in the p53 gene, an important gene in preventing cell cycle progression when there are DNA mutations, or signaling apoptosis (programmed cell death). These mutations seem to affect some base pair locations more than others, for example, the third base of codon 249 of the p53 gene appears to be more susceptible to aflatoxin-mediated mutations than nearby bases.

Glycogen synthase catalyzes the conversion of the glucosyl (Glc) moiety of uridine diphosphate glucose (UDP-Glc) into glucose to be incorporated into glycogen via an α(1→4) glycosidic bond. However, since glycogen synthase requires an oligosaccharide primer as a glucose acceptor, it relies on glycogenin to initiate de novo glycogen synthesis. In a recent study of transgenic mice, an overexpression of glycogen synthase and an overexpression of phosphatase both resulted in excess glycogen storage levels. This suggests that glycogen synthase plays an important biological role in regulating glycogen/glucose levels and is activated by dephosphorylation.

DD-transpeptidase is mechanistically similar to the proteolytic reactions of the trypsin protein family. DD-transpeptidase catalytic mechanism Crosslinking of peptidyl moieties of adjacent glycan strands is a two-step reaction. The first step involves the cleavage of the D-alanyl-D-alanine bond of a peptide unit precursor acting as carbonyl donor, the release of the carboxyl-terminal D-alanine, and the formation of the acyl- enzyme. The second step involves the breakdown of the acyl-enzyme intermediate and the formation of a new peptide bond between the carbonyl of the D-alanyl moiety and theamino group of another peptide unit.

In 1970, using bradykinin potentiating factor (BPF) provided by Sergio Ferreira, Ng and Vane found the conversion of angiotensin I to angiotensin II was inhibited during its passage through the pulmonary circulation. BPF was later found to be a peptide in the venom of a lancehead viper (Bothrops jararaca), which was a “collected-product inhibitor” of the converting enzyme. Captopril was developed from this peptide after it was found via QSAR-based modification that the terminal sulfhydryl moiety of the peptide provided a high potency of ACE inhibition. Captopril gained FDA approval on April 6, 1981.

Dedisimedi married Prince Kaikhosro II Jaqeli, a 22-year-old prince-atabag of Samtskhe, in 1545. Kaikhosro's rule over Samtskhe, one of the breakaway states of the Kingdom of Georgia, was marred by incessant Iranian–Ottoman rivalry over the territory, uneasy relations with neighboring Georgian polities, and internecine feuds. Installed through the Ottoman intervention, Kaikhosro ended up his reign, watching the western part of his principality being assimilated by the Ottomans and the eastern moiety—where he preferred to stay—being subjected to Iran. He died while visiting the court of Shah Tahmasp I at Qazvin in 1573.

Ubiquitin-specific protease 14 is an enzyme that in humans is encoded by the USP14 gene. This gene encodes a member of the ubiquitin-specific processing (UBP) family of proteases that is a deubiquitinating enzyme (DUB) with His and Cys domains. This protein is located in the cytoplasm and cleaves the ubiquitin moiety from ubiquitin-fused precursors and ubiquitinylated proteins. Mice with a mutation that results in reduced expression of the ortholog of this protein are retarded for growth, develop severe tremors by 2 to 3 weeks of age followed by hindlimb paralysis and death by 6 to 10 weeks of age.

Chemical structure of α-cubebene The dried cubeb berries contain essential oil comprising monoterpenes (sabinene 50%, α-thujene, and carene) and sesquiterpenes (caryophyllene, copaene, α- and β-cubebene, δ-cadinene, germacrene), the oxides 1,4- and 1,8-cineole and the alcohol cubebol. About 15% of a volatile oil is obtained by distilling cubeb with water. Cubebene, the liquid portion, has the formula C15H24 and comes in two forms, α- and β-. They differ only in the position of the alkene moiety, with the double-bond being endocyclic (part of the five- membered ring) in α-cubebene, as shown, but exocyclic in β-cubebene.

Crenarchaeol is a glycerol dibiphantanyl glycerol tetraether (GDGT) biological membrane lipid. It has an distinctive cyclohexane moiety and has been proposed as a specific biomarker for pelagic ammonia-oxidizing archaea (AOA). Structurally, the molecule consists of two long hydrocarbon chains that extend through the cell membrane and are bound on each to glycerol through ether linkage. Crenarchaeol can be preserved for hundreds of millions of years in the environment and is part of the TEX86 paleothermometer, a temperature proxy for sea surface temperatures that has been used to reconstruct paleoclimate through to the middle Jurassic (~160 Ma).

Danishefsky synthesis of peribysin Yong Qiang Tu's synthesis of the Alzheimer's disease medication galantamine likewise used this reaction in the presence of an acid- sensitive acetal group. Tu synthesis of galantamine Larry E. Overman's synthesis of laurenyne utilizes a one-pot oxidation with pyridinium chlorochromate followed by a Saegusa oxidation, tolerating the presence of a halogen and a sulfonate. Overman synthesis of laurenyne The synthesis of sambutoxin reported by David Williams uses a novel Saegusa–Ito oxidation involving an unprotected enol moiety. The enone product cyclized in situ to regenerate the enol and form the tetrahydropyran ring.

Unlike the previous components of the painting, Clan designs are sacred and initially did not appear on public paintings, although nowadays they can be seen on commercial paintings. A clan design may consist of a combination of symbols, geometric designs, and cross hatching, One clan symbol, for example, consists of a series of interlocking diamonds painted in particular colours, whilst another includes symbols of a “sugar-bag” (wild honey). A Yolngu person can immediately identify the clan and moiety of the painter from that design, which then also provides further context for interpreting the symbolism of the geometric designs.

The (1S, 6R, 1’S, 2’S)-stereochemistry and pharmacophore (in orange and black) required for good activity In an attempt to increase the potency and its antimicrobial spectrum, a series of synthetic and semisynthetic derivatives were investigated. Structure–activity relationship (SAR) studies have shown that the C(1) triol and the [4.2.2]-bicyclic ring were essential for bicyclomycin-rho inhibitory activity whereas the C(5)−C(5a) exomethylene moiety was not. Further SAR studies showed that 5a-substituted derivatives can be prepared that were an order of magnitude more efficient than bicyclomycin in the inhibition of rho.

By using a series of disproportionation reactions of symmetrical and asymmetrical framework, Benson and Buss concluded that neighboring atoms within the disproportionation reaction under study are not affected by the change. ; Symmetrical : Cl-CH2CH2-Cl + H-CH2CH2-H -> 2 Cl- CH2CH2-H ; Asymmetrical : H-CH2O-H + CH3-CH2CH2-CH3 -> CH3-CH2O-H + H-CH2O-CH3 In the symmetrical reaction the cleavage between the CH2 in both reactants leads to one product formation. that the neighboring carbons are not changed as the rearrangement occurs. In the asymmetrical reaction the hydroxyl–methyl bond is cleaved and rearranged on the ethyl moiety of the methoxyethane.

Lisdexamfetamine is a substituted amphetamine with an amide linkage formed by the condensation of dextroamphetamine with the carboxylate group of the essential amino acid L-lysine. The reaction occurs with retention of stereochemistry, so the product lisdexamfetamine exists as a single stereoisomer. There are many possible names for lisdexamfetamine based on IUPAC nomenclature, but it is usually named as or . The condensation reaction occurs with loss of water: :(S)- \+ (S)- -> (S,S)- \+ Amine functional groups are vulnerable to oxidation in air and so pharmaceuticals containing them are usually formulated as salts where this moiety has been protonated.

441 (Internet Archive). Successive escheats necessitated the renewal of the priory's endowments. In 1289 Prioress Beatrice conveyed her right of advowson of North Creak and Combs churches to Roger and Sarra, who in turn granted or regranted to her the manor of Flixton and moiety of the church, the advowson of Helmingham church (with land), a house with 26 acres in Wilby, Suffolk, a house with 29 acres in North Creak, and the advowsons of Dunston and Fundenhall, in pure alms.Blomefield, 'North Creke', p. 72; Final Concord, 17 Edward I, P.R.O. CP25(1)/285/23, no. 66.

The oligonucleotides translocated into the cell nucleus upon endosomal rupture triggered by NIR laser pulses. Continuous NIR radiation caused cell death because of excessive local heating of SWNT in vitro. Selective cancer cell destruction was achieved by functionalization of SWNT with a folate moiety, selective internalization of SWNTs inside cells labeled with folate receptor tumor markers, and NIR- triggered cell death, without harming receptor-free normal cells. Thus, the transporting capabilities of carbon nanotubes combined with suitable functionalization chemistry and their intrinsic optical properties can lead to new classes of novel nanomaterials for drug delivery and cancer therapy.

Following administration, estradiol benzoate acts as a prodrug of estradiol via cleavage by esterases into estradiol and the natural fatty acid benzoic acid. This cleavage occurs not only in the liver, but also in the blood and in tissues. Esters of estradiol like estradiol benzoate are readily hydrolyzed to estradiol, but have an extended duration when administered in via intramuscular or subcutaneous injection due to a depot effect afforded by their fatty acid ester moiety and consequent high lipophilicity. A long-lasting local tissue depot is formed by the injection that slowly releases estradiol benzoate into the circulation.

Studies have found that in REB-like structures, the imide function of the pyrrole segment acts to interact with Topoisomerase I, the main carbon backbone acts as an intercalative inhibitor, and the sugar moiety undergoes DNA groove binding. The latter two actually act in unison due to the three- dimensional structure of a glycosylated REB molecule. The Top1 inhibitor section binds to cleavable DNA-Top1 complexes so as to prevent the relegation step. Because of this, sensitivity is based on quantity of Top1 present, making cells undergoing constant reproduction and growth (namely tumor cells) most vulnerable.

This compound showed good activity in vivo and in models of pain and was developed up to phase II for the treatment of migraines but then terminated, as was the case with other NK1 receptor antagonists that were tested for the same indication. The third company, Pfizer, discovered a benzylamino quinuclidine structure, which was called CP-96345 (figure 1). CP-96345 has a rather simple structure, composed of a rigid quinuclidine scaffold containing a basic nitrogen atom, a benzhydril moiety and an o-methoxy-benzylamine group. This compound showed high affinity for the NK1 receptor, but it also interacted with Ca2+ binding sites.

The story of the sisters embody what the clans consider their religious law and it is traditionally told through paintings, sculptures, song and dance cycles. These sacred laws, also referred to as madayin, are specific to each clan and they are taught during three ceremonies. Because of the sacred nature of these rituals, there is a restricted access to them and a limited understanding of the knowledge shared during them. Djungguwan is considered the initiation ritual when young boys from the Dua moiety are circumcised and introduced to the cultural laws of their clan through the story of the sisters.

Specifically, different sugar groups attached at the sugar end of the steroid can alter the molecule's solubility and kinetics; however, the lactone moiety at the R group end only serves a structural function. In particular, the structure of the ring attached at the R end of the molecule allows it to be classified as either a cardenolide or bufadienolide. Cardenolides differ from bufadienolides due to the presence of an “enolide,” a five-membered ring with a single double bond, at the lactone end. Bufadienolides, on the other hand, contain a “dienolide,” a six-membered ring with two double bonds, at the lactone end.

Sanders, 1960, pp.106-107, Berry Pomeroy. Sanders (p.107) gives the date of death of Henry II de Pomeroy as 1207, which clearly conflicts with the fact of John Russell having married his widow in 1200 and sister of Doun Bardolf (1177–1205), lord of a moiety of the feudal barony of Shelford, Nottinghamshire, inherited from his mother Rose de Hanselin, who had married Thomas Bardolf (died between 1188 and 1194).Sanders, 1960, pp.76-77, Shelford The de la Pomeroy family came from La Pommeraye, Calvados, near Falaise, Normandy.Sanders, 1960, p.106, quoting "Anglo-Norman Families", p.

On Tuesday, February 14, 2012, Roche and its U.S. biotech unit Genentech announced that counterfeit Avastin had been distributed in the United States. The investigation is ongoing, but differences in the outer packaging make identification of the bogus drugs simple for medical providers. Roche analyzed three bogus vials of Avastin and found they contained salt, starch, citrate, isopropanol, propanediol, t-butanol, benzoic acid, di-fluorinated benzene ring, acetone and phthalate moiety, but no active ingredients of the cancer drug. According to Roche, the levels of the chemicals were not consistent; whether the chemicals were at harmful concentrations could not therefore be determined.

The ellagitannins are a diverse class of hydrolyzable tannins, a type of polyphenol formed primarily from the oxidative linkage of galloyl groups in 1,2,3,4,6-pentagalloyl glucose. Ellagitannins differ from gallotannins, in that their galloyl groups are linked through C-C bonds, whereas the galloyl groups in gallotannins are linked by depside bonds.MALDI-TOF Mass Spectrometric Analysis of Hydrolysable Tannins Ellagitannins contain various numbers of hexahydroxydiphenoyl units, as well as galloyl units and/or sanguisorboyl units bounded to sugar moiety. In order to determine the quantity of every individual unit, the hydrolysis of the extracts with trifluoroacetic acid in methanol/water system is performed.

Traditional Torres Strait religion can be characterised as totemic and ancestor worship, and as such the markai are the ancestors, and are specially revered. The ancestors are with the augadh totem, and the augadh generates the buwai clan/moiety, and the markai ultimately has a direct relationship to the augadh, though not necessarily being seen as being the augadh. In the traditional mythology, the world (arkath hole, apagoewa underfurrow/ditch/garden) is at the bottom of a sphere, with the sky (dapar) above and around it. The markai live in Kibu, the main gateway of which is in the west (Kibukuth Horizons End).