How to use inactive drug in a sentence? Find typical usage patterns (collocations)/phrases/context for "inactive drug" and check conjugation/comparative form for "inactive drug". Mastering all the usages of "inactive drug" from sentence examples published by news publications.
Fentanyl is a synthetic opioid structurally similar arylpiperidines. It is a strong μ-receptor agonist that is 80–100 times more potent to morphine, and has a fast onset with a shorter duration of action than morphine. It is metabolized in the liver by CYP3A4 enzymes to norfentanyl, an inactive drug.
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However, stomach acids are needed to digest proteins, vitamin B12, calcium, and other nutrients, and too little stomach acid causes the condition hypochlorhydria. The PPIs are given in an inactive form, which is neutrally charged (lipophilic) and readily crosses cell membranes into intracellular compartments (like the parietal cell canaliculus) with acidic environments. In an acid environment, the inactive drug is protonated and rearranges into its active form. As described above, the active form will covalently and irreversibly bind to the gastric proton pump, deactivating it.
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The approach has been to attach parts of genes expressed in cancer cells to other genes for enzymes not found in mammals that can convert a harmless substance into one that is toxic to the tumor. Most suicide genes mediate this sensitivity by coding for viral or bacterial enzymes that convert an inactive drug into toxic antimetabolites that inhibit the synthesis of nucleic acid. Suicide genes must be introduced into the cells in ways that ensure their uptake and expression by as many cancer cells as possible, while limiting their expression by normal cells. Suicide gene therapy for cancer requires the vector to have the capacity to discriminate between target and non target cells, between the cancer cells and normal cells.
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