Mimms could not impute the corporation's knowledge to those four CVS workers in Indiana.
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Left to their own devices, investors start to impute greater significance to key thresholds.
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The rule would strike the words of a senator, should they impute a colleague.
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Partisans impute evil to their adversaries, and the meritocratic elect have barred the gates.
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I think it's an energy thing, and you can impute that to whatever you want.
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On that basis, its last funding round would impute a multiple of 13 times revenue.
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We still impute sanity and rationality to classical architecture, as opposed to the madness we see in Gothic.
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The urge to impute beliefs, motives and mental states to mass murderers, moreover, is often misplaced, experts said.
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Efforts to impute political motivation to this case do a great disservice to Ms. Herbosa and the institution she leads.
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What he was being paid to do was to impute reputation and gravitas to an American company doing business globally.
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"They see this $36 billion endowment and the manicured lawns and they impute that onto all colleges and universities," Mr. Antony said.
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"We impute a lot of importance to it because there's pride, and we get to pretend we're 15 years old again," Mr. Costello said.
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No doubt, in the heat of the election, people will likely impute partisan motives to the Supreme Court justices who intervene in election-related disputes.
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His inaugural message seems quaint today, as politicians, operatives, and commentators bludgeon each other and impute the worst possible motives to those on the other side.
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Sometimes, though, Mr. Trump's statements leave his own staff in the dark, forcing them to impute a meaning to his words that might not actually exist.
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It's because there are certain people in the American public discourse who feel it necessary to impute bad motives to people who disagree and that's what Kimmel's doing here.
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We saw in the Muslim travel ban cases that courts have been fairly open about using those public statements in order to try to impute motive to governmental action.
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"We, as evangelical Christians, are really, really prone, it seems to me, to become so enthused with political figures that we just automatically impute to them almost superheroic status," he said.
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Indeed, one of the chief lessons of the past three years of political journalism is that it can be futile to impute rational intention onto the operation of Trump&aposs mind.
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The point is not to impute counterfactual gayness on notably heterosexual historical figures but to suggest that identity is created by context — and can just as easily be dissolved by it, too.
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The consumption and income data available in the U.S. are both subject to error, but the consumption data provide more information than income data to impute noncash housing benefits and the service flow from vehicle and home ownership.
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After then incorporating the market value of the Industrial assets ($71bn to $78n) and Capital assets ($111bn to $129bn), we impute a value for GE equity between -$2.47 to +$7.11, or just over $2/share at the midpoint.
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The administration argues that since existing data doesn't impute the citizenship status of everyone in the US, it's not good enough — and that, logically, having both existing records and new census data is better than just having one.
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It seems fair to impute at least some of Nuno's energetic contempt to de la Pava himself: This twee fucker in a vest, the kind of douche who corrects someone calling him a writer by specifying he's a novelist.
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My point here is that reasoned assessment involves more nuanced evaluative criteria, ones that do not essentialize racial identity, impute intent, or ignore the way distinct cultural forms hold differing degrees of power when it comes to racial relations.
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Nonetheless, in a sport as superstar-driven as basketball, there is good reason to impute the bulk of a great team's achievements to its strongest contributor—and, conversely, the blame for a middling club′s lack of accomplishments to its best player.
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Saez, 48, has been involved in a series of what are considered groundbreaking studies of U.S. income, inequality and economic mobility that involved both developing techniques to impute income based on holdings of wealth, and extensive access to U.S. Internal Revenue records.
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" 'Unbecoming a Senator': What the rule says Rule 19 of the Senate rules states that "No senator in debate shall, directly or indirectly, by any form of words impute to another Senator or to other Senators any conduct or motive unworthy or unbecoming a Senator.
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If we want to think about how a China that is economically so successful while making no changes to its one-party model challenges the democratic world then we may as well be clear about what we can, and can't, impute to the People's Republic.
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He made no such advance directive; he didn't want his fortune to be divided while he was alive, and even if he failed to anticipate his current condition, his children shouldn't impute to him the kind of foresight that they might find more convenient.
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Visa applicants "must consider the risk that a U.S. official will misinterpret their speech on social media, impute others' speech to them, or subject them to additional scrutiny or delayed processing because of the views they or their contacts have expressed," the lawsuit said.
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Senate Majority Leader Mitch McConnell had found Warren in violation of the Senate's Rule 19, which prevents senators from using "any form of words [to] impute to another Senator … any conduct or motive unworthy or unbecoming a Senator," for attempting to read the letter criticizing Sessions.
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" McConnell demanded that the presiding officer rule that Warren had violated Senate Rule XIX, which states, "No Senator in debate shall, directly or indirectly, by any form of words impute to another Senator or to other Senators any conduct or motive unworthy or unbecoming a Senator.
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Elizabeth Warren (D-MA) read from it late Tuesday night, Senate Majority Leader Mitch McConnell (R-KY) found her in violation of Senate Rule 19 — an obscure and rarely enforced restriction barring senators from using "any form of words [to] impute" the motives of another senator during floor debate.
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" McConnell, angered that Warren read King's words on the Senate floor, invoked Rule 19, a Senate provision in the Senate code of conduct that prohibits Senators from "directly or indirectly, by any form of words impute to another Senator or to other Senators any conduct or motive unworthy or unbecoming a Senator.
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" They argue that instead of treating polarization in the general electorate as a conflict over competing policies, the better measure is "affective polarization," which is their term for the way voters "not only increasingly dislike the opposing party," but are also willing to "impute negative traits to the rank-and-file of the out-party.
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And the point about Wright was not about him, it was about when he questioned, when President Obama, Candidate Obama was questioned about, "oh you can&apost impute Reverend Wright&aposs comments about US of KKK and all that on me," He was a lot closer to Wright than, the President is not close to Roseanne, he called and said congrats on the ratings, big deal, they don&apost even know each other.
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"I don't want to impute in any respect the motives of the Commonwealth of Virginia, but if it were the case that a state decided not to defend the Constitution, not to defend the legality of a districting plan that was adopted by the legislature, and that decision was made purely for partisan reasons, you would say that an elected official or a candidate who was severely, adversely affected by that should not be able to challenge it," Alito said.
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The Stokes' responded in what may be one of the most snarky and derisive comebacks of all time: We James and Elizabeth Stokes, of the City of London, were of Opinion that by our former Performances, we had establish'd to ourselves such a Reputation, as would effectively have secur'd us from the Trouble of any Hibernian Challenges, but finding these Comcomitants (as they call themselves) in Pursuit of Fame, are not susceptible of any Conviction of their Insufficiency to stand in Competition with us, but what they purchase at a very smart Expense, we shall for this once do them the Favour to comply with their Invitation, and hope they will have the Modesty to impute it more to their own Indiscretion, than to any Enmity of ours, if their imaginary Prospect of being Sharers in Renown, should be chang'd into a real Partnership in a defeated Combat.
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Once the data were returned to the statistics agencies it underwent further processing to ensure consistency and to impute missing values.
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This section provides that in an action for slander ("words spoken and published"), brought by a female plaintiff in respect of words that impute unchastity or adultery to her, it is not necessary for her to allege or prove that she has suffered special damage. The word "unchastity" is not confined to unchastity with a man. To call a woman a "lesbian" is to impute "unchastity" to her.Kerr v.
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Regression imputation has the opposite problem of mean imputation. A regression model is estimated to predict observed values of a variable based on other variables, and that model is then used to impute values in cases where the value of that variable is missing. In other words, available information for complete and incomplete cases is used to predict the value of a specific variable. Fitted values from the regression model are then used to impute the missing values.
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Under s8(b) therefore, the jury is allowed a wide latitude in applying a hybrid test to impute intention or foresight (for the purposes of recklessness) on the basis of all the evidence.
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Computer vision is a field that includes methods for acquiring, processing, analyzing, and understanding images and high-dimensional data from the real world to produce numerical or symbolic information, e.g., in the forms of decisions. Computer vision has many applications already in use today such as facial recognition, geographical modeling, and even aesthetic judgment. As amazing as all these are, machines still struggle to interpret visual impute accurately if said impute is blurry, and if the viewpoint at which stimulus are viewed varies often.
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Here we only know how many people have ages above 100, not their distribution. Producers of survey data sometimes release the average of the censored amounts to help users impute unbiased estimates of the top group.
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Hence, some degree of objectivity must be brought to bear as the basis upon which to impute the necessary component(s). It is always reasonable to assume that people of ordinary intelligence are aware of their physical surroundings and of the ordinary laws of cause and effect (see causation). Thus, when a person plans what to do and what not to do, he will understand the range of likely outcomes from given behaviour on a sliding scale from "inevitable" to "probable" to "possible" to "improbable". The more an outcome shades towards the "inevitable" end of the scale, the more likely it is that the accused both foresaw and desired it, and, therefore, the safer it is to impute intention.
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A number of different methods exist for genotype imputation. The three most widely used imputation methods are - Mach, Impute and Beagle. All three methods utilize hidden markov models as the underlying basis for estimating the distribution of the haplotype frequencies. Mach and Impute2 are more computationally intensive compared with Beagle.
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Lord Byron mentions Godoy in his Childe Harold's Pilgrimage (Canto the First, XLVIII), where a Spanish lusty muleteer... chants "Viva el Rey" / And check his song to execrate Godoy, / The royal wittol Charles... etc. and in the note to these lines he explains that it is to this man that the Spaniards universally impute the ruin of their country.
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In 1924 Karl Engisch received his doctorate. Supervised by Otto Eger, his dissertation concerned Imperative Theory,"Die Imperativentheorie", jurisprudence dissertation, Gießen 1924 (unpublished), excerpts published in "Auszüge aus den der juristischen Fakultät der Universität Gießen vorgelegten Dissertationen". Gießen 1925, pp. 42–47 (faculty files) an aspect of Legal Philosophy, and a theory which German sources impute to Jeremy Bentham and John Austin.
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Both Impute and Mach are based on different implementations of the product of the conditionals or PAC model. Beagle groups the reference panel haplotypes into clusters at each SNP to form localized haplotype-cluster model that allows it to dynamically vary the number of clusters at each SNP making it computationally faster than Mach and Impute2. For more information, see imputation (genetics).
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There are several software packages available to impute genotypes from a genotyping array to reference panels, such as 1000 Genomes Project haplotypes. These tools include MaCH Minimac, IMPUTE2 and Beagle. Each tool provides specific pros and cons, in terms of speed and accuracy. Additional phasing tools such as SHAPEIT2 allow prephasing of input haplotypes, for improved imputation accuracy and computational performance.
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These categories are (1) behaviors toward other people, (2) behaviors toward the gods themselves and (3) behaviors toward nature and/or the environment. While people impute these concerns to gods' minds, they often correspond to ecological challenges. This correspondence establishes why religious ideas often covary with ecological problems in the social and natural world: because these ideas enact behavioral strategies that solve them.
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He also lived in Brussels and Wiesbaden. Many aspects of his life between 1891 and 1897 remain unknown. Darien's lifelong paucity of official earnings has inspired some of his readers to impute the fictional exploits of Georges Randal, the daring burglar protagonist of his 1897 novel Le Voleur, to its author. In 1899 Darien married Suzanne Caroline Abresch, born in 1863 in London, of German parents.
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Lord Mackay held the dismissal was unfair. First, the employer failed to show the principal reason for dismissal because it did not distinguish among the three complaints. Second, the employer relied upon the second complaint as part of the principal reason for dismissal. He said that a tribunal cannot impute a reason to the employer’s dismissal which it did not have at the time of dismissal.
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The Nurse says, "Why heap fresh infamy upon thy house and outsin thy mother? Impious sin is worse than monstrous passion; for monstrous love thou mayest impute to fate, but crime, to character." In the end, Phaedra can be seen to meet a fate similar to that of her mother, for her unnatural lust brings about the creation of the monstrous bull that dismembers Hippolytus.
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Lines 37–40: "Nor you, ye Proud, impute to these the fault, If Memory o'er their tomb no trophies raise, Where through the long-drawn aisle and fretted vault The pealing anthem swells the note of praise." that an Englishman, Thomas Gray, had placed in a popular poem first published in 1751 (see Adaptations and parodies of Elegy Written in a Country Churchyard).Banneker, 1795, p. 2 (1) § 1.
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Beyfus won the case for them and they were each awarded £2500 and costs of £4000. In the same year he represented Jaime Ortiz-Patiño in an action against the Sunday Graphic. He was awarded £20,000 after the newspaper withdrew their defence. In 1959 the entertainer Liberace sued the Daily Mirror for publishing an article written by William Connor (Cassandra) that appeared to impute that he was homosexual.
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The Second Circuit affirmed the District Court's finding in favor of Kodak. The court found that since Atex was incorporated in Delaware, that Delaware laws applied. The court then considered both an alter ego theory and an agency liability theory that could impute responsibility for Atex's actions to Kodak. The court also briefly discussed and rejected the possibility of Kodak being the apparent manufacturer or of concerted tortious action.
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In point > of fact, later in the 20th century we witnessed the terrible genocides of > Cambodia and Rwanda. I would welcome it if critics of my work would limit > themselves to dealing with the substance of my positions rather than falsely > impute to me ulterior motives.Lewy, Guenter, Reply to Tony Barta, Norbert > Finzsch and David Stannard, Journal of Genocide Research, Volume 10, Issue > 2, June 2008, p. 307.
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However, he had little success in winning over his enemies in the party and was quick to impute sinister motives on their part. His real problems came from the Democratic efforts to undo Reconstruction and gain control. Democrats in Vicksburg launched a coup in December 1874. When the sheriff called on his supporters to restore him to office, there was a battle that ended in the Colfax Massacre.
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They are also not permitted to impute improper motives to other MPs, or to refer to the conduct or character of any MP or public servant other than that person's conduct as an MP or public servant.S.O. 50(6) and (10). There are restrictions on discussing the conduct of the president or a Judge or Judicial Commissioner of the Supreme Court;Constitution, Arts. 22L(3)–(7) and 99; S.O. 50(8) and (9).
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Genotype imputation is carried out by statistical methods that combine the GWAS data together with a reference panel of haplotypes. These methods take advantage of sharing of haplotypes between individuals over short stretches of sequence to impute alleles. Existing software packages for genotype imputation include IMPUTE2, Minimac, Beagle and MaCH. In addition to the calculation of association, it is common to take into account any variables that could potentially confound the results.
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The memorization of the information serves as a way to impute clan loyalty to younger generations. Among Peoples of the Caucasus, traditionally, large scale land disputes could sometimes be solved with the help of mutual knowledge of whose ancestors resided where and when. A teip's ancestral land was thus held as sacred, because of its close link to teip identity. It was typically marked by clan symbols, including the clan cemetery, tower, and sanctuary.
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Some aspects of the physical world are so inevitable that it is always reasonable to impute knowledge of their incidence. So if A abandons B on a beach, A must be taken to foresee that the tide comes in and goes out. But the mere fact that B subsequently drowns is not enough. A court would have to consider where the body was left and what level of injury A believed that B had suffered.
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He was not > called upon to stake his life upon "a reasonable chance to get away". If he > had done so he may well have figured as the deceased at the trial, instead > of as the accused person. Moreover, one must not impute to a person who > suddenly becomes the object of a murderous attack that mental calm and > ability to reason out ex post facto ways of avoiding the assault without > having recourse to violence.
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115 clusters (10.6%) were not visited due to security problems. The IFHS argues that past mortality is likely to be higher in these missed clusters. Ratios derived from comparing their surveyed clusters to corresponding data from Iraq Body Count were used to impute elevated mortality rates to these missed clusters. Using this method, the IFHS derives death rates for the missed clusters in Baghdad that are 4.0 times as high as the clusters visited by the survey in Baghdad.
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Others have used the concept of authorial stance to describe the way in which authors position themselves relative to their own texts, and another group have used the concept of interpersonal stance to describe the way the communicative goals of individual participants shape a communicative interaction. Others have drawn on Daniel Dennett's concept of the intentional stance to describe the way humans tend to impute intentions and mental states to those with whom they engage in communication.
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Marshall's endorsement, WIBW, Nick Viviani (AP), July 31, 2018. Retrieved October 3, 2018. In July, Donald Trump's 2020 campaign manager, Brad Parscale, stated that Watkins and a second candidate for the seat, Dennis Pyle, had put out campaign ads with Trump's photo on them, without authorization, to impute endorsements by the president.Trump/Pence 2020 campaign manager Brad Parscale shared a special message with Kansas Republicans: Please don’t vote for Steve Watkins, Washington Post, Dave Weigel, August 7, 2018.
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Modern speakers marketed as 'digital' are always analog speakers, in most cases driven by an analog amplifier. The widespread use of the term 'digital' with speakers is a marketing ploy intended to claim better suitability with 'digital' source material (e.g., MP3 recordings), or impute 'higher technology' than some other speaker, and perhaps higher price. If pressed, manufacturers may claim the term means the product is 'ready' for input from digital players; this is true of essentially all speaker systems.
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To incur liability for a crime, a person must have both committed a prohibited act (the actus reus, which must be willed: see automatism) and have had an appropriate mental element (the mens rea) at the relevant time (see the technical requirement for concurrence). A key component of the mens rea is any knowledge that the alleged criminal might have had. For these purposes, knowledge can be both actual and constructive--i.e., the court can impute knowledge where appropriate.
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It is the largest primary handloom cooperative society in the state and country as well. Since its inception, it has been working as a production and marketing society by providing impute and marketing support regularly to its weaver members under a co-operative framework. This institution being a leading one in the state is widely known for its efficient commitment, for the uplifting of the scheduled caste and scheduled tribes and economically backward classes of society, including women.Sambalpuri Bastralaya Handloom Cooperative Society Ltd.
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Characteristics of the Elegy. The revised rhyme stated: > Nor you ye proud, impute to these the blame > If Afric's sons to genius are unknown, > For Banneker has prov'd they may acquire a name, > As bright, as lasting, as your own.Bedini, 1972, p. 324. Supported by Andrew, George and Elias Ellicott and heavily promoted by the Society for the Promotion of the Abolition of Slavery of Maryland and of Pennsylvania, the early editions of the almanacs achieved commercial success.Bedini, 1999, pp. 184-187.
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Polydore Vergil says that Greenshield "was greatly renowned neither at home nor in warfare".Vergil, Polydore, Polydore Vergil's English History, from an Early Translation, Volume 36, Camden society, 1846, p.34. However, in Elizabethan England he acquired a reputation as a great warrior who is supposed to have led an expedition against the French at Hainaut. Michael Drayton refers to him in Poly-Olbion as "Brute Green-Shield, to whose name we providence impute / Divinely to revive the land's first conqueror, Brute".
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To impute missing data in statistics, NMF can take missing data while minimizing its cost function, rather than treating these missing data as zeros. This makes it a mathematically proven method for data imputation in statistics. By first proving that the missing data are ignored in the cost function, then proving that the impact from missing data can be as small as a second order effect, Ren et al. (2020) studied and applied such an approach for the field of astronomy.
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Many methods that exploit phylogenetic inference use the 16SRNA gene for Archea and Bacteria and the 18SRNA gene for Eukaryotes. Phylogenetic comparative methods (PCS) are based on the comparison of multiple traits among microorganisms; the principle is: the closely they are related, the higher number of traits they share. Usually PCS are coupled with phylogenetic generalized least square (PGLS) or other statistical analysis to get more significant results. Ancestral state reconstruction is used in microbiome studies to impute trait values for taxa whose traits are unknown.
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It can be a desire for wealth with insufficient desire to benefit others; or a desire to benefit others suppressed by an excessive desire to keep what money one has; or the desire for too much wealth. Aristotle said that "meanness we always impute to those who care more than they ought for wealth" and "there seem to be many kinds of meanness". The translation of what Aristotle meant is not without problems. Aristotle's actual word ἐλευθερία (eleutheria) corresponds with both liberality and freedom.
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A common analogy, popularized by Herbert Spencer, presents these parts of society as "organs" that work toward the proper functioning of the "body" as a whole. In the most basic terms, it simply emphasizes "the effort to impute, as rigorously as possible, to each feature, custom, or practice, its effect on the functioning of a supposedly stable, cohesive system". For Talcott Parsons, "structural-functionalism" came to describe a particular stage in the methodological development of social science, rather than a specific school of thought.
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Hence, the notion of vicarious liability for companies and other business entities exclusively depends on the ability to impute knowledge. The test is one of identification. If the natural person who acts can be "identified with the mind of the company" when performing the actions forming the actus reus, all the relevant mental elements will be imputed to the company. This test, sometimes termed the alter ego test, is objective and cannot be distracted by the job title or description formally held by the human agent.
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I appeal to women in the world! I appeal to all men worthy > of the name. Help! White women, white boys are in danger everyday, every > hour of the day as long as a black is allowed to have power over a white > women!" An avowed white supremacist, Beveridge sought to impute the worse about black men, saying in one speech: > "Victims of the promiscuous passions of the blacks are found half dead in > meadows and ditches, their clothes in tatters, their delicate young bodies > torn by the brutality of the attacks.
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Version 0.1 of IVEware was developed in the late 1990s by Trivellore Raghunathan, Peter W. Solenberger, and John Van Hoewyk and released in 1997 as beta software with an official release in 2002 from the Survey Research Center, University of Michigan Institute for Social Research. Version 0.2 was released in 2011 and the newest version, V 0.3, was released in 2017. The software includes seven modules: IMPUTE, BBDESIGN, DESCRIBE, REGRESS, SASMOD, SYNTHESIZE, and COMBINE. IVEware can be run with SAS, Stata, R, SPSS or as a stand-alone tool under the Windows or Linux environment.
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In our modern world, PDM in business field of finance are mostly base on the three categories: Autocratic, Collective-participative and consensus participative. Most of the financial organization practices the first category which is the Autocratic; this is because leaders have little or no trust for their employees. The Autocratic category of Decision Making allow the leader to make decision entirely on his or her own without any impute from others and take full responsibility for that decision. This style of decision-making is usually the best choice in case of emergency according to leadershipmanagement.
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Therefore, an ISP can seek protection under section 2.4(1)(b) ("intermediary exception"). In concluding, Binnie notes that it is impossible to impute actual knowledge on an ISP of a copyright violation, and thus cannot impose liability. If an ISP received notice that :someone might be using neutral technology to violate copyright (as with the photocopier in the CCH case) is not necessarily sufficient to constitute authorization, which requires a demonstration that the defendant did "(g)ive approval to; sanction, permit; favour, encourage" (CCH, at para. 38) the infringing conduct.
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Some data analysis techniques are not robust to missingness, and require to "fill in", or impute the missing data. Rubin (1987) argued that repeating imputation even a few times (5 or less) enormously improves the quality of estimation. For many practical purposes, 2 or 3 imputations capture most of the relative efficiency that could be captured with a larger number of imputations. However, a too-small number of imputations can lead to a substantial loss of statistical power, and some scholars now recommend 20 to 100 or more.
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In his book Christian Integrity, Thieme covers the divine system in great detail, with its priority, purpose, policy, objectives, and authority. In the Scripture the system is also referred to as the sphere of love (John 15:9-10), since it emphasizes love as the supreme virtue of the Christian life. The virtue love of the Christian life includes reciprocal love for God and impersonal love for all mankind. As the believer advances within God's system and develops capacity for love and happiness, God is free to impute maximum blessings to him.
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Sen used the sex ratio of 1.022 for sub-Saharan Africa in work done in 2001, to avoid comparing advanced countries to developing ones. Just as Sen believed, in their study they find no evidence to impute the missing women to birth discrimination such as sex- selective abortions or neglect. To account for the high number of young women missing they discovered that HIV/AIDS was the main cause, surpassing malaria and maternal mortality. Anderson and Ray estimated an annual excess female death rate 600,000 due to HIV/AIDS alone.
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"Accusation in a mirror" is a false claim that accuses the target of something that the perpetrator is doing or intends to do. The name was coined by an anonymous Rwandan propagandist in Note Relative à la Propagande d’Expansion et de Recrutement. Drawing on the ideas of Joseph Goebbels and Vladimir Lenin, he instructed collagues to "impute to enemies exactly what they and their own party are planning to do". By invoking collective self- defense, propaganda justifies genocide, just as self-defense is a defense for individual homicide.
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It is suggested that Prospero's way of regularly checking the time of day during the play might be satirizing the concept of the unities. In An Apology for Poetry (1595), Philip Sidney advocates for the unities, and complains that English plays are ignoring them. In Shakespeare's The Winter's Tale the chorus notes that the story makes a jump of 16 years: :Impute it not a crime :To me or my swift passage, that I slide :O'er sixteen years and leave the growth untried :Of that wide gapShakespeare, William. The Winter's Tale.
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Structural equation models are often used to assess unobservable 'latent' constructs. They often invoke a measurement model that defines latent variables using one or more observed variables, and a structural model that imputes relationships between latent variables. The links between constructs of a structural equation model may be estimated with independent regression equations or through more involved approaches such as those employed in LISREL. Use of SEM is commonly justified in the social sciences because of its ability to impute relationships between unobserved constructs (latent variables) from observable variables.
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With the advent in the mid-2000s of genotyping chips, which could measure hundreds of thousands of single-letter variations (SNPs) across the genome, deCODE statisticians were able to accurately phase segments of the genome - to understand the parental source of segments - and then impute genotypes measured in some people across the entire population.A Kong et al., "Detection of sharing by descent, long-range phasing and haplotype imputation," Nature Genetics, Vol. 40, Number 9, pp 1068–1075 (August 2008) This effectively multiplies the size and power of any study.
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We conclude that the Government is not liable under the Federal Tort Claims Act for injuries to servicemen where the injuries arise out of or are in the course of activity incident to service. Without exception, the relationship of military personnel to the Government has been governed exclusively by federal law. We do not think that Congress, in drafting this Act, created a new cause of action dependent on local law for service-connected injuries or death due to negligence. We cannot impute to Congress such a radical departure from established law in the absence of express congressional command.
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He is credited with having brought Persian language and literature into the mainstream of international contemporary writing. There is no doubt that Hedayat was the most modern of all modern writers in Iran. Yet, for Hedayat, modernity was not just a question of scientific rationality or a pure imitation of European values. In his later years, feeling the socio-political problems of the time, Hedayat started attacking the two major causes of Iran's decimation, the monarchy and the clergy, and through his stories he tried to impute the deafness and blindness of the nation to the abuses of these two major powers.
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600x600px The user initiates the process by providing a set of training data and identifying the prediction column, which sets up the problem to solve. For example, the prediction column might contain possible values of yes or no in response to an offered incentive. In the data pre-processing stage, AutoAI applies numerous algorithms, or estimators, to analyze, clean (for example, remove redundant information or impute missing data), and prepare structured raw data for machine learning (ML). The next is automated model selection that matches the data with a model type, such as classification or regression.
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But his original distinction survives as the core of modern explanations of rational social action: instrumental means are thought to be value-free conditionally- efficient tools, and value-rational ends are thought to be fact-free unconditionally-legitimate rules. As Weber studied human action in religious, governmental, and economic settings, he found peoples' reasoning evolving and often contaminating itself by converting conditional means into unconditional ends. Pre-modern peoples impute to animate and inanimate objects alike the free-will and purpose they find in human action—a belief called animism. They use instrumentally efficient means to control non-human wills.
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Under the Red Flag test, a service provider may lose their Safe Harbor eligibility if the Court finds that it failed to take action when the infringing activity is apparent due to the service provider's awareness of certain facts or circumstances.District Court opinion, page 21. While IO argued that its copyright registrations in the works provided constructive criticism, the Court found that none of the videos in question contained copyright notices in them. While one of them contained IO's trademark several minutes into the clip, it didn't rise to a level of awareness to impute knowledge of infringement.
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Oey married a local Peranakan woman, who gave birth to a daughter and three sons: Oey Holland, Oey Tamba and Oey Macau. Luitenant Oey Thai Lo died around 1838 in Batavia, and passed down a supposed inheritance of 2 million guilders for his children. One of his children, Oey Tamba Sia, gained notoriety for his womanizing, and more fatally for masterminding several murders, which he tried to impute to his social rival Lim Soe Keng Sia, the Majoor's son-in-law. After he was convicted, the young Oey was sentenced to hang by the Dutch East Indies government.
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In the United States, a zero-l coupon bond has original issue discount (OID) for tax purposes. Instruments issued with OID generally impute the receipt of interest, sometimes called phantom income, even though the bonds do not pay periodic interest. Therefore, zero coupon bonds subject to US taxation should generally be held in tax-deferred retirement accounts, to avoid taxes being paid on future income. Alternatively, when a zero coupon bond issued by a US state or local government entity is purchased, the imputed interest is free of U.S. federal taxes and, in most cases, state and local taxes.
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According to Vasubandhu, the absolute, reality itself (dharmatā) is non-dual, and the dichotomy of perception into perceiver and perceived is actually a conceptual fabrication. For Vasubandhu, to say that something is non-dual is that it is both conceptually non-dual and perceptually non-dual. To say that "I" exist is to conceptually divide the causal flux of the world into self and other, a false construct. Just the same, to say that an observed object is separate from the observer is also to impute a false conception into the world as it really is - perception only.
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In this context, the basic idea of simulation is that the attributor attempts to mimic the mental activity of the target by using his own psychological resources. In order to understand the mental state of another when observing the other acting, the individual imagines herself/himself performing the same action, a covert simulation that does not lead to an overt behavior. One critical aspect of the simulation theory of mind is the idea that in trying to impute mental states to others, an attributor has to set aside her own current mental states, and substitutes those of the target.
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Although the marginal note to the section purports to abolish the doctrine of "constructive malice", it did not abolish the concept of felony, the rules relating to the arrest of felons or the general rules specifying the test for the mental element which the juries were to apply. Hence, the Act did not abolish the principles of expressed malice or implied malice, i.e. malice could be implied by the words and expressions used by the accused, or there was a set of circumstances from which malice could be implied. These were objective tests that enabled the court to impute or "construct" the malice.
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The technique then finds the first missing value and uses the cell value immediately prior to the data that are missing to impute the missing value. The process is repeated for the next cell with a missing value until all missing values have been imputed. In the common scenario in which the cases are repeated measurements of a variable for a person or other entity, this represents the belief that if a measurement is missing, the best guess is that it hasn't changed from the last time it was measured. This method is known to increase risk of increasing bias and potentially false conclusions.
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9, 2003, pàg. 135-148. . It was Beuter who warned about having found the legend "according to what I found written" in a supposed "personal manuscript". Even though one cannot impute the invention of the legend to Beuter with absolute security, it seems clear that the resource of the supposed "personal manuscript" either refers to a previous source or was subterfuged to avoid any subsequent criticism. Historian Agustí Aloberro i Pericay points out that, in any case, whether he was the inventor of Beuter's legend or if the legend is an adaptation of an earlier version that circulated in Valencia, the "personal manuscript" would not be much prior to 1551.
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Ronald Arthur Burroughs (4 June 1917 – 24 May 1980) was a British diplomat who served as Her Majesty's Ambassador to Algeria between 1971 and 1973.Obituary in The Times, Mr Ronald Burroughs, May 29, 1980, p.18 A letter he wrote to Sir James Craig in 1971 concerning The Spanish Ambassador’s Suitcase became the title of a book by Matthew Parris and Andrew Bryson on amusing unofficial letters of diplomacy. In the book Parris states that in ‘diplomatic circles The Spanish Ambassador’s Suitcase despatch is by impute probably the greatest funny of them all’.The Spanish Ambassador’s Suitcase, Stories from the Diplomatic Bag, by Matthew Parris and Andrew Bryson.
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In his statement, he claimed that he had "deprived the government of its goal of sentencing me to death," and that "the fact that I have entered an agreement with the government is purely a tactical choice on my part and in no way legitimates the moral authority of the government to judge this matter or impute my guilt." The terms of the plea agreement were that Rudolph would be sentenced to four consecutive life terms. He was sentenced July 18, 2005, to two consecutive life terms without parole for the 1998 murder of a police officer.Associated Press, "Eric Rudolph Gets Life Without Parole ", July 18, 2005.
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Manganiello 1989 p. 148 Eliot, in a letter to John Hayward dated 27 August 1942, explained why he changed the wording: > I think you will recognise that it was necessary to get rid of Brunetto for > two reasons. The first is that the visionary figure has now become somewhat > more definite and will no doubt be identified by some readers with Yeats > though I do not mean anything so precise as that. However, I do not wish to > take the responsibility of putting Yeats or anybody else into Hell and I do > not want to impute to him the particular vice which took Brunetto there.
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Sections 2 and 3 state that a Senator shall not impute to another Senator "by any form of words" any conduct or motive that is unworthy or unbecoming of a Senator and shall not speak offensively toward a U.S. state. Sections 4 and 5 outline what happens if a Senator is found in violation of this rule, including how a Senator can appeal a ruling against him or her. Sections 6 and 7 empower the Presiding Officer to maintain order in the chamber's galleries and disallows Senators from bringing to attention anything or anyone in the galleries. Section 7 cannot be suspended, even by unanimous consent of the Senate.
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Commercial colonisation activity in the region changed dramatically in the 6th century BC when the Carthaginians achieved dominance of the western Mediterranean after the fall of the Phoenician city- states of Canaan to the Persian empire. This new phase of colonisation involved the expansion of Punic territory through military conquest; later Greek sources impute the destruction of Tartessos to Carthaginian military assaults on the Seville of the Cuesta del Rosario, assuming it to be Tartessian at the time. Carthaginians had caused the collapse of Tartessos by 530 BC, either by armed conflict or by cutting off Greek trade in support of the Phoenician colony of Gades (present-day Cádiz). Carthage also besieged and took over Gades at this time.
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The poet says that he has not seen that the young man needed to be described in a flattering way ("painting"), and so he has not attempted it. Line 4 ("I found, or thought I found") suggests that he has been rebuked for being silent, which is also suggested in line 9 ("this silence for my sin you did impute"). "Modern quill" suggests an inadequately ordinary kind of writing, and the whole of line 7 ("How far a modern quill doth come too short") contains a sexual inadequacy pun aimed the rival poet or poets. The third quatrain is so insistent on the poet's silence ("silence" "dumb" "mute") that it suggests deliberateness.
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The epic hero, Pope says, has wisdom, courage, and love. Therefore, the mock-hero should have "Vanity, Impudence, and Debauchery". As a wise man knows without being told, Pope says, so the vain man listens to no opinion but his own, and Pope quotes Cibber as saying, "Let the world... impute to me what Folly or weakness they please; but till Wisdom can give me something that will make me more heartily happy, I am content to be ". Courage becomes a hero, Pope says, and nothing is more perversely brave that summoning all one's courage just to the face, and he quotes Cibber's claim in the Apology that his face was almost the best known in England.
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One condition stipulated for a Count of the Empire was that he should have an income of at least 30,000 francs. In France as in Britain, the increased use of various forms of paper money to fund the European War led to currency depreciation, which makes it particularly hard to impute a modern equivalent value to the requirement, but it does appear that in De Paellaert was enjoying a life style that he could not afford. This was a normal condition for many of Napoleon's courtiers: the endlessly devious Talleyrand himself was under financial pressure during this period. The assumption at court was that when the time came the emperor would help his loyal servants expunge their debts.
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When Illumina began selling machines that could economically sequence whole genomes, deCODE was able to directly sequence several thousand Icelanders and then impute whole genome sequence (WGS) data for virtually the entire population. This represents one of the largest single collections of WGS data in the world, and the first results of its analysis were published in 2015 in a special edition of Nature Genetics."The Genomes of Icelanders," Nature, permanent link, 25 March 2015 The direct sequencing of tens of thousands of more people since then has enabled routine searches for ever rarer variants at an unprecedented scale.DO Arnar and R Palsson, "Genetics of common complex diseases: a view from Iceland," European Journal of Internal Medicine, Vol.
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In this framework, stories that seemed to impute dishonorable conduct to the gods were often simply dismissed as false, and as being nothing more than the "imagination of poets." Greek and Roman thinkers continued to wrestle, however, with the problems of natural evil and of evil that we observe in our day-to-day experience. Influential Roman writers such as Cicero and Seneca, drawing on earlier work by the Greek philosophers such as the Stoics, developed many arguments in defense of the righteousness of the gods, and many of the answers they provided were later absorbed into Christian theodicy. On the other hand, the philosopher Lucretius in De rerum natura, rejected the divinity in nature as a cause of many evils for humanity.
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Judges normally do not define intention for juries, and the weight of authority is to give it its current meaning in every day language as directed by the House of Lords in R v Moloney,[1985] AC 905 where can be found references to a number of definitions of intention using subjective and objective tests, and knowledge of consequences of actions or omissions. Intention is generally defined in terms of foresight of particular consequences and a desire to act or fail to act so that those consequences occur. It is distinguished from recklessness because, on a subjective basis, there is foresight but no desire to produce the consequences. But the perennial problem has always been the extent to which the court can impute sufficient desire to convert recklessness into intention.
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The doctrine of original sin thus does not impute the sin of the father to his children, but merely states that they inherit from him a "human nature deprived of original holiness and justice", which is "transmitted by propagation to all mankind". In the theology of the Catholic Church, original sin is the absence of original holiness and justice into which humans are born, distinct from the actual sins that a person commits. The absence of sanctifying grace or holiness in the new-born child is an effect of the first sin, for Adam, having received holiness and justice from God, lost it not only for himself but also for us. This teaching explicitly states that "original sin does not have the character of a personal fault in any of Adam's descendants".
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Fitzgibbon returned the challenge, and on the Attorney-General declining to take it back, drew the attention of the court to the occurrence. Thereupon the Lord Chief Justice, Edward Pennefather, suspended the proceedings, in order to afford the parties time for reflection, observing that "the Attorney-General is the last man in his profession who ought to have allowed himself to be betrayed into such an expression of feeling as has been stated to have taken place." The Attorney-General thereupon expressed his willingness to withdraw the note, in the hope that Fitzgibbon would withdraw the words which had elicited it, and Fitzgibbon disclaiming any intention to impute conduct unworthy of a gentleman to the Attorney-General, the matter dropped, and the trial proceeded Annual Register, 1844, Chron. 323.
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According to the empiricist view associated with the 18th- century Scottish philosopher David Hume, we do not actually observe causes and effects, but merely experience constant conjunction of sensory events, and impute causality between the observations. More precisely, one finds merely counterfactual causality—that altering condition A prevents or produces state B—but finds no further causal relation between A and B, since one has witnessed no either logical or natural necessity connecting A and B.Gary Goertz & Jack S Levy, ch 2 "Causal explanation, necessary conditions, and case studies", pp 9–46, in Jack Levy & Gary Goertz, eds, Explaining War and Peace: Case Studies and Necessary Condition Counterfactuals (New York: Routledge, 2007), p 11. In the 20th century, as a formula to scientifically answer Why? questions, logical empiricist Carl Hempel and Paul Oppenheim explicated the deductive-nomological model (DN model).
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R. 226 deals with the issue of the power of a court to impute intention based on foresight. The defendants threw their victim from a third floor balcony and were charged with attempted murder. The judge directed the jury that they could infer intention if there was a high degree of probability that the victim would be killed and if the defendants knew "quite well that in doing that there was a high degree of probability" that the victim would be killed. The Court of Appeal did not accept that the reference to "very high degree of probability" was a misdirection, but Lloyd LJ. stated that in the rare cases where an expanded direction is required to include foresight, courts should use virtual certainty as the test, rather than high probability (see also R v Woollin [1998] 3 WLR 382 (HL)).
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She campaigned for the inclusion of women delegates on the government boards of schools and for the provision of state aid to theatres. She was a strong advocate of religious education in the city's schools and called for the authorities to look after prostitutes who had become infected with sexually transmitted diseases through their work. She contributed a number of articles to "Roland", a regional party newspaper, dealing with women's right to vote, in which she criticised the attitudes of all the political parties, analysing the position as it then stood, and not fearing to impute some of the responsibility for the situation she criticised to women themselves. At the beginning of 1933, exploiting the intensifying political polarisation and the resulting parliamentary deadlock, the Hitler government took power, and lost no time in transforming Germany into a one- party dictatorship.
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Author Hristo Stoyanov has been critical of the tendency to impute false intellectualism to some of those engaging in legal transgressions as a way of protest, seeing the methods employed by the protesters between 23 and 24 July 2013 as a threat to the fundamentals of Bulgarian democracy. Analyst Petar Klisarov has voiced his disapproval of the demonstrators (especially the emigrant students who participated in protests on 26 December 2013 and 3 January 2014) for flaunting Bulgarian legal regulations, for example by behaving disrespectfully towards police officers and blocking the city traffic on a whim, suggesting that they would have been much more disciplined and law- abiding if the activities were taking place abroad. Sofia mayor Yordanka Fandakova is also claimed to have been overly permissive of the demonstrators at the expense of the other members of society.
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Rita Barberá in 2015 On 21 April 2016, this investigating judge therefore requested her indictment for money laundering to the Tribunal Supremo.Dos jueces piden al Supremo que impute a Rita Barberá por blanqueo de capitales y desobediencia, El País, 21 April 2016 On 13 September 2016 the Tribunal Supremo opened a formal investigation, usually the step before an indictment, and the People's Party asked her to resign her senate seat.Ximo Puig: "Barberá debe dejar la vida política por decencia" El País, 13 September 2016 She chose instead to formally leave the party and to become an independent senator, remaining answerable only to the Tribunal Supremo and keeping her senator salary.Rita Barberá se da de baja en el PP pero se aferra al escaño en el Senado, El País, 14 September 2016 Until her death, she continued to socialize and vote with the party that she had formally left.
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According to the General Biographical Dictionary of 1815 in Kenrick's later years he drank very heavily, a habit which probably caused his relatively early death: > In his latter days, his constitution was so much injured by inebriety, that > he generally wrote with a bottle of brandy by his elbow, which at length > terminated his career June 10, 1779, less lamented than perhaps any person > known in the literary world, yet possessed of talents which, under a steady > and virtuous direction, might have procured him an honourable place among > the authors of his time. Indeed, Kenrick wrote revealingly of himself that he drank spirits (aqua vitae), to pen acid (aqua fortis): :The Wits, who drink water and suck sugar- candy, :Impute the strong spirit of Kenrick to brandy. :They are not so much out: the matter, in short, is--- :He sips aqua vitae, and spits aqua fortis.Quoted in The English Portion of the Library of Ven.
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In a warm August's Sunday, a spacious beach house on Ostia's free beach is used in turn by many characters. A volleyball female team led by a martial coach; a lonely English priest with two penises and two grunty friends searching for girls; two sisters who want to seduce an austere insurance official; two old lovers who want to enjoy their first love meeting; two physically trained soldiers and an elderly couple with a young pregnant granddaughter, Teresina, trying to impute the paternity to a simple minded cousin. Surrounded by various people, all of which are integral and conscientious part of it, the protagonists try to solve their problems or achieve their goals, thinking to turn reality to their own personal vision of things. Away from everyday life, in that holiday bracket there is time to study and make imaginative moves and countermoves, but they will not be able to change their outcomes.
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In 1827 and 1828 he again proposed resolutions on this subject, and saw his proposals become law in 1829. In 1820 Burdett had again come into serious conflict with the government. Having severely censured its action in print with reference to the Peterloo Massacre, he was prosecuted at Leicester assizes, fined £1,000, and committed to prison by Justice Best for three months for the crime of "composing, writing, and publishing a seditious libel" with explanation: > My opinion of the liberty of the press is that every man ought to be > permitted to instruct his fellow subjects; that every man may fearlessly > advance any new doctrines, provided he does so with proper respect to the > religion and government of the country; that he may point out errors in the > measures of public men; but he must not impute criminal conduct to them. The > liberty of the press cannot be carried to this extent without violating > another equally sacred right; namely, the right of character.
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Asked at one such inquiry to explain his urging his countrymen to resist the tithes, and why he should not feel himself responsible for the violence that accompanied the Tithe War, he replied: > [N]o man ought to be condemned for exhorting people to pursue justice in a > certain line, though he may foresee that in the pursuit of that justice the > opposition given to those who are proceeding in a just course may produce > collision, and that collision lead to the commission of crime; but our duty, > as I conceive, is to seek for the injustice, and there to impute the crime… > It is to that injustice, and not to those who pursue a just course for the > attainment of a right end, that the guilt is to be ascribed. Seeing his readiness and resource, the Duke of Wellington remarked that Doyle examined the committee rather than was examined by them.
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Through the 1970s she concentrated on sculptures and interior constructions using preformed timber elements such as boards and beams, with a frequent preference for simple soft pine timber. Between 1991 and 1996 Sax produced a succession of "wind sculptures" and flag, using fabrics in combination with colourful so-called "wind clothes" and "air clothes" to cloth female bodies for a "geometric ballet" presentation, evincing a shameless spirit of freedom to be true to oneself, of optimism and good cheer, in ways that two decades later, in a more sombre age, can be construed as almost indelicately cheerful or frivolous, although there is no reason to impute any sort of conscious political intent at the time to the artist. They were generally presented in public places where they readily drew the eye, or in theatres in the context of avant-garde stage shows. From the very start, Sax's artistic approach has been defined in part by an interest in sculptural aspects and related aspects of sculptural-spatial themes, along with express relationships to the relevant architectural spaces.
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He said that the requirement that people be removed "as soon as reasonably practicable" was directed at limiting the duration of detention to as little as necessary, but it did "not mean that the detention... is limited to a maximum period expiring when it is impracticable to remove or deport the person." Chief Justice Gleeson, in dissent, said that in interpreting legislation, the courts "do not impute to the legislature an intention to abrogate or curtail certain human rights or freedoms (of which personal liberty is the most basic) unless such an intention is clearly manifested by unambiguous language". He concluded that the provisions requiring that unlawful non-citizens be detained were ambiguous in that in a situation such as Al-Kateb's, where it became impossible to fulfil the purpose for which he was detained, the law was not clear as to whether the result is that the detention should be suspended until the purpose becomes possible again, or that the detention should continue indefinitely. The Act did not deal with a situation like Al-Kateb's.
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The court stated that to successfully move forward on an alter ego theory to impute liability for Atex's actions to Kodak, the plaintiff would have to show that both that the two companies operated as a "single economic entity" and that there would have to be some unfairness or inequity involved in not piercing the veil. The court emphasized that while fraud could be used to pierce the veil, it was not an essential element. In considering whether the two companies formed a "single economic entity" the court could consider: if the subsidiary was adequately capitalized, if it was solvent, if it paid dividends, how the records were kept, how the officers function, whether corporate formalities were observed, whether funds were taken away for use by the parent company, and if it operated as a facade.Fletcher, 68 F.3d at 1458, quoting The court ruled that these factors did not lead to a conclusion that it should pierce the veil, noting that using a cash management system and a limited overlap in the board of directors between the two companies was insufficient.
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The Kantian thesis claims that in order for the subject to have any experience at all, then it must be bounded by these forms of presentations (Vorstellung). Some scholars have offered this position as an example of psychological nativism, as a rebuke to some aspects of classical empiricism. Kant's thesis concerning the transcendental ideality of space and time limits appearances to the forms of sensibility—indeed, they form the limits within which these appearances can count as sensible; and it necessarily implies that the thing- in-itself is neither limited by them nor can it take the form of an appearance within us apart from the bounds of sensibility (A48-49/B66). Yet the thing-in- itself is held by Kant to be the cause of that which appears, and this is where an apparent paradox of Kantian critique resides: while we are prohibited from absolute knowledge of the thing-in-itself, we can impute to it a cause beyond ourselves as a source of representations within us.
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This should not be confused with parody advertisements, where a fictional product is being advertised for the purpose of poking fun at the particular advertisement, nor should it be confused with the use of a coined brand name for the purpose of comparing the product without actually naming an actual competitor. ("Wikipedia tastes better and is less filling than the Encyclopedia Galactica.") In the United States, the Federal Trade Commission (FTC) defined comparative advertising as “advertisement that compares alternative brands on objectively measurable attributes or price, and identifies the alternative brand by name, illustration or other distinctive information.”Federal Trade Commission Commercial Practice Rule 16 CFR §14.15 n 1 (2002) This definition was used in the case Gillette Australia Pty Ltd v Energizer Australia Pty Ltd.(2002) 193 ALR 629 Similarly, the Law Council of Australia recently suggested that comparative advertising refers to “advertising which include reference to a competitor’s trademark in a way which does not impute proprietorship in the mark to the advertiser.”P. Armitage in M.A. Murphy, “Legal aspects of comparative advertising and a strategy for its use”, Queensland University of Technology law journal, Vol.
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On May 31, 2011, the 18th Civil Chamber of the Court of Rio de Janeiro upheld the sentence of first instance that Amorim condemned to pay R$30,000 in damages to Ali Kamel. In the first degree sentence, Judge ledir Dias de Araújo stressed that journalistic criticism are sustainable and encourage people to form their opinions, but can not randomly or falsely impute crime to someone. "It remained proven abuse committed by the defendant to expose your opinion about the author's person, to relate it to the authorship of this book and also extremely offensive way, which entails the duty to indemnify.". To the judge, there is no doubt that there was offense "in two aspects, ie, it reaches its subjective honor, the intimate pain suffered by such placements and still achieves the objective honor, the aftermath of the fact the social environment they live and in the family ".STF mantém condenação de Paulo Henrique AmorimPaulo Henrique Amorim terá de indenizar Ali Kamel por chamá-lo de racista On 14 September 2011, Amorim was convicted by the court of Rio de Janeiro to indemnify R$100,000 for pain and suffering and accusation without proof to the lawyer Nelio Machado.
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Yet by running the company's growing number of directly sequenced whole genomes through the genotyping data and genealogies as a scaffold, the company's statisticians have been able to impute very high definition WGS on the entire population. The result has been the ability to conduct GWAS studies using from 20 to 50 million variants, and to systematically search for rare variants that either cause or confer very high risk of extreme versions of common phenotypes, and thereby pointing directly to putative drug targets.An early overview and 20 million SNPs were put in the public domain in DF Gudbjartsson et al., "Sequence variants from whole genome sequencing a large group of Icelanders," Nature Scientific Data, vol 2, art 150011 (March 2015); dozens of subsequent papers using this scale of data are on the publications page of deCODE's website from 2015 onward The value of this approach is best known from the model of PCSK9, in which the study of families with extremely high cholesterol levels and early-onset heart disease led to an understanding of the key role of this gene and the development of a new class of cholesterol-fighting drugs.
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